methotrexate has been researched along with Central Nervous System Diseases in 230 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 160 (69.57) | 18.7374 |
| 1990's | 19 (8.26) | 18.2507 |
| 2000's | 19 (8.26) | 29.6817 |
| 2010's | 26 (11.30) | 24.3611 |
| 2020's | 6 (2.61) | 2.80 |
| Authors | Studies |
|---|---|
| McNeer, JL; Schmiegelow, K | 1 |
| Bou, GA; Castilho, AJ; Garcia-Santibanez, R; Hutto, SK | 1 |
| Apfel, LS; Cuoco, JA; In, A; Rogers, CM; Stopa, BM; Stump, MS | 1 |
| Billick, M; Liu, J; Monsour, D; Wang, X | 1 |
| Kidd, DP | 1 |
| Fukumura, M; Imai, R; Kameyama, K; Sasaki, A; Sasaki, H; Tsuda, N; Tsujikawa, H; Yoshida, K | 1 |
| Dominović-Kovačević, A; Grgić, S; Ilić, TV; Mavija, S; Vukojević, Z | 1 |
| Deckert, M; Dreyling, M; Illerhaus, G; Korfel, A; Schlegel, U; von Baumgarten, L | 1 |
| Dağlı, M; Keles Oğlu, KS; Koplay, M; Paksoy, Y; Sivri, M | 1 |
| Earle, B; Ramsay, ES; Wolf, DS | 1 |
| Chen, J; Ngo, D; Rosenthal, J | 1 |
| Cossburn, MD; Harris, MJ; Pengas, G | 1 |
| Amoura, Z; Benameur, N; Cohen Aubart, F; Cotteret, C; Haroche, J; Hie, M; Junot, H; Mathian, A; Miyara, M; Riller, Q; Tilleul, P | 1 |
| Kawano, Y; Kodama, Y; Kusuda, M; Mitsunobu, T; Nakagawa, S; Nishikawa, T; Okamoto, Y | 1 |
| Brosch, S; Lindemann, J; Reiter, R; Smith, E | 1 |
| Fisher, PG | 1 |
| Arkfeld, DG; Metyas, S; Tawadrous, M; Yeter, KC | 1 |
| Morgensztern, D; Peddi, PF; Peddi, S; Santos, ES | 1 |
| Akiyama, H; Hasegawa, Y; Tsuchiya, A | 1 |
| Abe, S; Asashima, H; Ebe, H; Hagiwara, S; Hirota, T; Kondo, Y; Kurata, I; Matsumoto, I; Ogishima, H; Sumida, T; Suzuki, T; Takahashi, H; Tsuboi, H; Umeda, N; Yagishita, M | 1 |
| Berrios, I; Ghiran, S; Ionete, C; Jun-O'Connell, A | 1 |
| Bird, TG; Child, F; Morris, SL; Wain, EM; Whittaker, S | 1 |
| Balevic, SJ; Shah, A | 1 |
| Amoura, Z; Bitoun, S; Borie, R; Boutin, DL; Bouvry, D; Cohen Aubart, F; Godeau, B; Haroche, J; Hie, M; Mahevas, M; Mathian, A; Nunes, H; Papo, T; Pottier, C; Psimaras, D; Sacre, K; Valeyre, D | 1 |
| Amoura, Z; Bouvry, D; Cohen Aubart, F; Dehais, C; Devilliers, H; Galanaud, D; Haroche, J; Hie, M; Mathey, G; Mathian, A; Nunes, H; Pottier, C; Psimaras, D; Valeyre, D | 1 |
| Behin, A; Choquet, S; Drouet, T; Guillevin, R; Hoang Xuan, K; Psimaras, D | 1 |
| Julian, BA; Kew, CE; Nabors, LB; Palmer, CA; Przekwas, AM | 1 |
| Loeffler, M; Pfreundschuh, M; Schmitz, N; Zeynalova, S | 1 |
| Dietrich, PY | 1 |
| Buffardi, S; Cianciulli, E; Mangione, A; Marchese, L; Menna, G; Misuraca, A; Nastro, A; Parasole, R; Petruzziello, F; Poggi, V | 1 |
| Ernemann, U; Fenchel, M; Hauser, TK; Horger, M; Korn, A | 1 |
| Froklage, FE; Heimans, JJ; Reijneveld, JC | 1 |
| Houzen, H; Maruo, Y; Nakano, F; Sakushima, K; Sasaki, H; Tajima, Y; Yabe, I; Yoshida, K | 1 |
| Do, DV; Goldstein, DA; Le-Nguyen, XT; Lee, TK; Nguyen, QD; Rao, NA; Sepah, YJ; Vasconcelos-Santos, DV | 1 |
| Ardura, MI; Harker-Murray, P; Johnson-Welch, SF; Pokala, H; Seikaly, M; Twombley, K; Weinberg, A | 1 |
| Vega, RS | 1 |
| D ANGIO, GJ; EVANS, AE; MITUS, A | 1 |
| BOGLE, JM; BRUBAKER, CA; HAMMOND, D; HYMAN, CB; WILLIAMS, K | 2 |
| RITTER, M; ZUKERMAN, E | 1 |
| Adkins, D; Blum, W; Brown, R; Chohan, R; Devine, S; DiPersio, JF; Goodnough, LT; Graubert, T; Khoury, H; Tomasson, M; Vij, R | 1 |
| Belohradsky, BH; Lohse, P; Stojanov, S; Weiss, M | 1 |
| Hayat, GR; Kaiboriboon, K; Olsen, TJ | 1 |
| Beck, JF; Dölken, R; Harms, D; Hartwig, M; Schröder, H; Weigel, S | 1 |
| Chayama, K; Endo, M; Hara, JI; Hasegawa, D; Hashii, Y; Hori, H; Horibe, K; Isogai, M; Matsumoto, K; Miyaji, R; Nishimura, S; Sato, A; Suzuki, N; Tanizawa, A; Uami, I; Umeda, K; Wakazono, Y; Yagi, K; Yoshida, M | 1 |
| Adams, H; Alyman, C; Catania, L; Jandet-Brunet, C; Neuberg, DS; Robaey, P; Romero, I; Sallan, SE; Silverman, LB; Stevenson, K; Turek, J; Waber, DP | 1 |
| Aricò, M; Egeler, RM; Filipovich, AH; Gadner, H; Henter, JI; Horne, A; Imashuku, S; Janka, G; Ladisch, S; Trottestam, H; Webb, D | 1 |
| Abromowitch, M; Bowman, WP; Chen, CH; Crom, WR; Evans, WE; Simone, JV; Stewart, CF | 1 |
| Kaplan, RS; Wiernik, PH | 1 |
| Albo, V; Hammond, D; Karon, M; Leikin, S; Miller, DR; Sather, H | 1 |
| Ojeda, VJ; Walters, MN | 1 |
| Lippens, RJ | 1 |
| Bakshi, S; Berger, P; Brecher, ML; Cohen, ME; Duffner, PK; Ettinger, LJ; Freeman, A; Parthasarathy, KL | 1 |
| Hiraishi, Y; Kuribayashi, T; Oshima, Y; Shitara, T; Suetake, N | 1 |
| Armata, J; Balwierz, W; Bogusławska-Jaworska, J; Ciepielewska, D; Kaczmarek-Kanold, M; Kościelniak, E; Ochocka, M; Radwańska, U; Sońta-Jakimczyk, D; Sroczyńska, M | 1 |
| Brecher, ML; Burgert, EO; Chevalier, L; Forman, E; Freeman, AI; Gilchrist, GS; Glicksman, AS; Hananian, J; Harris, M; Holland, JF; Jones, B; Kung, F; Leventhal, B; Maurer, H; Necheles, T; Patterson, RB; Pleuss, H; Sinks, LF; Weil, M; Weinberg, V | 1 |
| Hattori, S; Kitajima, K; Nagashima, H; Sato, Y; Watanabe, A | 1 |
| Chessells, J; Leiper, A; Rogers, D | 1 |
| Belasco, JB; Grossman, RI; Packer, RJ | 1 |
| Folami, AO; Seriki, O; Williams, CK | 1 |
| Feasby, TE; Gilbert, JJ; Hahn, AF | 1 |
| Galletti, F; Sturniolo, MG | 1 |
| Pozzi, DH | 1 |
| Evans, AE | 1 |
| Fujimoto, T; Hasegawa, K; Hiyoshi, Y; Ito, M; Kim, PY; Kuriya, N; Yokoyama, T | 1 |
| Berger, P; Brecher, ML; Freeman, AI; Kinkel, W; Ochs, JJ; Sinks, LF | 1 |
| Gadner, H; Hanefeld, F; Müller, S; Rating, D; Riehm, H; Siegert, M; Siemes, H | 1 |
| Nesbit, ME; O'Leary, M; Woods, WG | 1 |
| Finne, PH; Moe, PJ; Seip, M | 1 |
| Fujimoto, T; Hasegawa, K; Hiyoshi, Y; Ito, M; Kadoya, S; Kawai, S; Koizumi, S; Komazawa, M; Kuriya, N; Mimaya, J; Sasaki, K; Shingaki, Y; Yokoyama, T | 1 |
| Abe, Y; Asakura, A; Endo, N | 1 |
| Baehner, RL; Harris, RE; McCallister, JA; Provisor, DS; Weetman, RM | 1 |
| Burke, JS; Cohen, JR; Coleman, CN; Rosenberg, SA | 1 |
| Eppinger-Helft, M; Garay, G; Hidalgo, G; Lein, J; Macchi, A; Muriel, FS; Pavlovsky, S; Russo, C; Santos, M; Suárez, A | 1 |
| Gropp, C; Havemann, K | 1 |
| Esterhay, RJ; Grove, WR; Markus, SD; Wesley, MN; Wiernik, PH | 1 |
| Berliner, S; Gallant, LA; Garfinkel, D; Pinkhas, J; Rothenberg, M; Shaklai, M; Shoenfeld, Y | 1 |
| Korsager, S; Laursen, B; Munck Mortensen, T | 1 |
| Barnes, HM; Prchal, JT; Scott, CW | 1 |
| Fujimoto, T; Fukui, M; Kitamura, K; Sasaki, K; Shingaki, Y | 1 |
| Airo, P; Balestrieri, G; Cattaneo, R; Chofflon, M; Francia, A; Priori, R; Tincani, A; Troianello, B; Valesini, G; Zambruni, A | 1 |
| Bernini, JC; Chappell, WB; Fort, DW; Griener, JC; Kamen, BA; Kane, BJ | 1 |
| Crist, WM; Harris, MB; Krance, RA; Land, VJ; Pinkel, D; Pullen, DJ; Ravindranath, Y; Shuster, JJ | 1 |
| Backstrom, L; Boyett, J; Crist, W; Frankel, L; Harris, M; Iyer, R; Land, V; Pullen, J; Shuster, J; van Eys, J | 1 |
| Tarbell, NJ; Waber, DP | 1 |
| Bergmann, L; Geissler, RG; Hacker, H; Hoelzer, D; Knupp, B; Walker, B | 1 |
| Baughman, RP; Broderick, JP; Brott, TG; Lower, EE | 1 |
| Camitta, B; Lauer, SJ; Mahoney, DH; Nitschke, R; Shuster, JJ; Steuber, CP; Winick, N | 1 |
| Boiardi, A; Pozzi, A; Salmaggi, A; Silvani, A | 1 |
| Hashimoto, T; Hirohata, S; Suda, H | 1 |
| Morimatsu, M | 1 |
| Britton, JM; Davidson, A; Leach, MO; McVicar, D; Payne, G; Tait, DM; Watson, M | 1 |
| Aviner, S; Cohen, IJ; Goshen, Y; Kornreich, L; Shuper, A; Stark, B; Stein, J; Steinmetz, A; Yaniv, I | 1 |
| Di Cataldo, A; Lo Nigro, L; Schiliro, G | 1 |
| Suda, H | 1 |
| Barta, U; Ständer, K; Wollina, U | 1 |
| Bessell, EM; Byrne, P; Graus, F; López-Guillermo, A; Montserrat, E; Nomdedeu, B; Petit, J; Verger, E; Villá, S | 1 |
| Moore, BE; Smith, TW; Somers, NP | 1 |
| Chessells, JM; Harrison, CJ; Richards, SM; Vora, AJ; Watson, SL | 1 |
| Frei, E; Pitman, SW | 1 |
| Braier, JL; Bugnard, E; De Bellis, R; de Sijvarger, SR; Eppinger-Helft, M; Failace, R; Garay, GE; Guman, L; Ojeda, FG; Pavlovsky, S; Ponzinibbio, C; Sackmann-Muriel, F; Saslavsky, J; Svarch, E; Vergara, B | 1 |
| Bleyer, WA; Pizzo, PA; Poplack, DG | 2 |
| Allen, JC | 1 |
| Malpas, JS | 1 |
| Haghbin, M | 2 |
| Blau, HJ; Hille, M; Kittner, KH; Kruse, H | 1 |
| Beard, ME; Brearley, RL; Crowther, D; Freeman, JE; Lister, TA; Malpas, JS; Oliver, RT; Paxton, AM; Whitehouse, JM; Woodruff, RK; Wrigley, PF | 1 |
| Bleyer, WA; Poplack, DG | 1 |
| Graham-Pole, J; Malpas, JS; Parker, D; Paxton, A | 1 |
| Brecher, ML; Freeman, AI; Sinks, LF; Wang, JJ | 1 |
| Bove, KE; Iacuone, JJ; Lampkin, BC; Wong, KY | 1 |
| Galicich, JH; Haghbin, M | 1 |
| Burgert, EO; Colligan, RC; Gilchrist, GS; Groover, RV; Houser, OW; Ivnik, RJ; Klass, DW; Obetz, SW; Smithson, WA | 1 |
| Sweet, DL; Ultmann, JE | 1 |
| Pochedly, C | 5 |
| Chessells, JM; Gribbin, MA; Hardisty, RM | 1 |
| Fujimoto, T; Furusho, K; Hasegawa, A; Ito, M; Kin, H; Yokoyama, T | 1 |
| Burchenal, JH | 1 |
| Fujimoto, T; Goya, N; Hiyoshi, Y; Ito, M; Yokoyama, T | 1 |
| Bleyer, AW | 1 |
| Halvorsen, K; Skullerud, K | 1 |
| Kinugawa, N; Koide, R; Sasaki, M; Taguchi, N; Takao, A; Tsunematsu, Y | 1 |
| Campbell, RH; Chessells, JM; Marshall, WC | 1 |
| Deisseroth, AB; Glaubiger, DL; Kent, HC; Levine, AS; Magrath, IT; Pizzo, PA; Poplack, DG; Ziegler, JL | 1 |
| Jaffe, N | 1 |
| Walters, TR | 1 |
| Ascari, E; Balduini, C; Fontana, G; Ricevuti, G; Rizzo, SC; Santagati, G | 1 |
| Blom, J; Law, IP | 1 |
| Feldges, AJ; Nussbaumer, A | 1 |
| Biggar, RJ; Nkrumah, FK; Perkins, IV | 1 |
| Alexander, M; Daniels, JR | 1 |
| Del Principe, D; Digilio, G; Iannetti, P; Multari, G | 1 |
| Herman, MM; Long, TF; Rubinstein, JL; Wilbur, JR | 1 |
| MacLennan, CM | 1 |
| Mauer, AM; Simone, JV | 1 |
| Considine, B; Lusher, JM; Ravindranath, Y; Sarnaik, S; Zeulzer, WW | 1 |
| Hara, M; Higaki, T; Ishigame, Y; Kobayashi, Y; Nitta, Y | 1 |
| Aaronson, AG; Hajdu, SI; Melamed, MR | 1 |
| Cohen, HJ; Hauch, TW; Kremer, WB; Mason, D; Shelbourne, JD | 1 |
| Osieka, R; Schmidt, CG | 1 |
| Fujimoto, T; Hasegawa, K; Kishida, K; Shin, H; Take, H | 1 |
| Graf, N; Pees, HW; Radtke, H; Schwamborn, J | 1 |
| Canellos, GP; Harrington, DP; Jochelson, MS; Klatt, MM; Pinkus, GS; Rosenthal, DS; Shipp, MA; Skarin, AT; Yeap, BY | 1 |
| Bennett, JM; Cohen, P; Kahn, J; Kaplan, L; Levine, AM; Metroka, C; Rarick, MU; Rodman, N; Walsh, C; Wernz, JC | 1 |
| Balis, FM; Blaney, SM; Poplack, DG | 1 |
| Diener, HC; Ehninger, G; Majer, K; Marquardt, B; Schmidt, H; Stäb, U | 1 |
| Jonsson, OG; Kamen, BA | 1 |
| Howells, DW; Hyland, K; Levinsky, RJ; Smith, I; Strobel, S | 1 |
| Brodzki, M; Deptala, A; Konopka, L; Krämer, M; Pawelski, S; Swencz-Szczepanik, K | 1 |
| Steinherz, PG | 1 |
| Becker, MA | 1 |
| Furst, DE; Kremer, JM | 1 |
| Arnet, B; Baumgartner, C; Beck, D; Berchtold, W; Bertrand, AM; Bleher, EA; Caflisch, U; Delaleu, B; Feldges, A; Stucki, F | 1 |
| Brinch, L; Evensen, SA; Stavem, P | 1 |
| Castel, V; Esquembre, C; Ferris, J; Verdeguer, A | 1 |
| Kolmannskog, S; Moe, PJ; Seip, M; Wesenberg, F | 1 |
| Kremer, JM; Lee, JK | 1 |
| Hällgren, R; Oberg, G; Venge, P | 1 |
| D'Angio, G; Goldwein, JL; Meadows, AT; Packer, RJ; Rorke, LB | 1 |
| Carbone, G; Leone, G; Marra, R; Massaro, A; Pagano, L; Storti, S; Teofili, L | 1 |
| Jurd, J; Milliken, S; Poulgrain, P; Vincent, PC; Young, GA | 1 |
| Muchi, H; Satoh, T; Taniguchi, Y | 1 |
| Ben-Nun, A; Cohen, IR; Przuntek, H; Vohl, ML; Wekerle, H; Westarp, ME | 1 |
| Bell, BA; Whitehead, VM | 1 |
| Brecher, ML | 1 |
| Bizzi, B; Leone, G; Marra, R; Pagano, L; Ricerca, BM; Storti, S; Teofili, L | 1 |
| Abe, I; Aoyama, H; Chiba, Y; Haneda, Y; Kawamura, S; Mikami, T; Sakata, Y; Sawada, Y; Yamaya, T; Yoshida, Y | 1 |
| Aur, RJ; Berg, R; Hustu, HO; Ochs, JJ; Rivera, G; Simone, JV | 1 |
| Cordingley, FT; Day, TJ | 1 |
| Advani, SH; Dinshaw, KA; Gopal, R; Kamat, DM; Nadkarni, KS; Nair, CN; Rao, DN; Saikia, TK | 1 |
| Beschorner, WE; Clark, AW; Patchell, RA; Santos, GW; White, CL | 1 |
| Dickinson, A; Fail, B; Finney, R; Hamilton, PJ; Paul, B; Proctor, SJ; Reid, MM; Saunders, P; Taylor, P; Thompson, RB | 1 |
| Hartwich, G; Soyka, D; Taghavy, A | 1 |
| Burchenal, JH; Dowling, MD; Tan, CT | 1 |
| Booth, AE; Spiers, AS | 1 |
| Jensen, KB; Petersen, JH; Reske-Nielsen, E; Sogaard, H | 1 |
| Lampkin, B; Mauer, AM; McWilliams, NB | 1 |
| Komp, DM | 1 |
| Borges, WH; Dyer, A; Hackl, E; Lipp, V; Pierce, M | 1 |
| Cendrowski, W; Riekkinen, PJ; Rinne, UK | 1 |
| Styri, OB | 1 |
| Schaafsma, S | 1 |
| Aghai, E; Kende, G; Ramot, B; Ravid, M | 1 |
| Sinks, LF | 1 |
| Fickers, M; Haak, HL; Speck, B | 1 |
| Aur, RJ; Hustu, HO; Simone, JV; Verzosa, MS; Wood, A | 1 |
| Aur, RJ; Hustu, HO; Pinkel, D; Simone, JV; Verzosa, MS | 1 |
| McIntosh, S; Pearson, HA | 1 |
| Eppinger-Helft, M; Pavlovsky, S; Sackmann Muriel, F | 1 |
| Auclerc, G; Bernard, J; Boiron, M; Bussel, A; Delobel, J; Dresch, C; Flandrin, G; Gemon, MF; Izrael, V; Jacquillat, C; Loisel, JP; Najean, Y; Rain, D; Schaison, G; Seligmann, M; Tanzer, J; Weil, M; Weisgerber, C | 1 |
| Simone, J | 1 |
| Glidewell, OJ; Holland, JF | 1 |
| Pinkel, D; Simone, J | 1 |
| Szalay, GC | 1 |
| Rokicka-Milewska, R | 1 |
| Aronson, AS; Garwicz, S; Sörnäs, R | 1 |
| Pantazopoulos, N; Sinks, LF | 1 |
| Andino Pavlovsky, A; Braier, JL; De Sijvarger, SR; Eppinger-Helft, M; Hidalgo, G; Ojeda, FG; Pavlovsky, S; Peñalver, JA; Sackmann Muriel, F | 1 |
| Borns, PF; Rancier, LF | 1 |
| Lie, SO | 1 |
| Abdulsalam, M; Markum, AH; Muslichan, S; Odang, O; Wahidijat, I | 1 |
| Sullivan, MP | 1 |
| Armata, J; Cyklis, R; Legutko, L | 1 |
| Simone, JV | 1 |
| Dano, K; Nissen, NI | 1 |
| Block, JB; Carbone, PP; Haskell, CM; Leventhal, BG; Selawry, OS | 1 |
| Considine, B; Cook, JC | 1 |
| Kozlowska, J; Rokicka-Milewska, R | 2 |
| Borella, L; George, P; Hernandez, K; Holton, C; Hustu, O; Pinkel, D | 1 |
| Kanner, SP; Serpick, AA; Walker, MD; Wiernik, PH | 1 |
| Fisher, BJ; Gross, S; Melhorn, DK; Newman, AJ | 1 |
| Auvert, B; Hurel, G; Theron, HP | 1 |
| Bernard, J; Boiron, M; Bussel, A; Dreyfus, B; Jacquillat, C; Larrieu, MJ; Loisel, JP; Rouesse, T; Weil, M | 1 |
| de Vaan, GA; Marcar, JR; Schretlen, ED | 1 |
| Brubaker, C; Hartmann, J; Leikin, S; Murphy, ML; Wolff, J | 1 |
| Meyer-Beeck, D; Oehme, J | 1 |
| Bluming, AZ; Carbone, PP; Fass, L; Morrow, RH; Ziegler, JL | 1 |
| Carnelli, V; Masera, G | 1 |
| Fernbach, DJ; Griffith, KM; Haddy, TB; Sullivan, MP; Vietti, TJ; Watkins, WL | 1 |
29 review(s) available for methotrexate and Central Nervous System Diseases
| Article | Year |
|---|---|
Management of CNS Disease in Pediatric Acute Lymphoblastic Leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Central Nervous System Neoplasms; Child; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies | 2022 |
Central Nervous System Lymphoproliferative Disorder Secondary to Methotrexate: A Systematic Literature Review and Case Illustration.
Topics: Arthritis, Rheumatoid; Central Nervous System; Central Nervous System Diseases; Humans; Immunosuppressive Agents; Lymphoproliferative Disorders; Methotrexate | 2023 |
Neurosarcoidosis: clinical manifestations, investigation and treatment.
Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal; Brain; Central Nervous System Diseases; Diagnosis, Differential; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methotrexate; Sarcoidosis; Spinal Cord; Treatment Outcome | 2020 |
A case of central nervous system lesion pathologically characterized by angiocentric, T-cell-rich lymphoid cell infiltrates: a case report and literature review.
Topics: Adrenal Cortex Hormones; Adult; Central Nervous System; Central Nervous System Diseases; Chemoradiotherapy; Combined Modality Therapy; Epstein-Barr Virus Infections; Humans; Lymphomatoid Granulomatosis; Magnetic Resonance Imaging; Male; Methotrexate; T-Lymphocytes; Treatment Outcome | 2021 |
Novel Use of Rituximab in Treatment of Refractory Neurosarcoidosis in an 11-Year-Old Girl.
Topics: Central Nervous System Diseases; Child; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Methotrexate; Optic Nerve; Prednisolone; Rare Diseases; Retreatment; Rituximab; Sarcoidosis; Severity of Illness Index; Treatment Failure; Treatment Outcome | 2019 |
Central nervous system toxicities of chemotherapeutic agents.
Topics: Antineoplastic Agents; Central Nervous System Diseases; Cisplatin; Cytarabine; Fluorouracil; Humans; Ifosfamide; Methotrexate; Neurotoxicity Syndromes; Posterior Leukoencephalopathy Syndrome; Vidarabine; Vincristine | 2014 |
A case of neurosarcoidosis secondary to treatment of etanercept and review of the literature.
Topics: Adult; Antirheumatic Agents; Arthritis, Juvenile; Central Nervous System Diseases; Cognition Disorders; Etanercept; Female; Humans; Immunosuppressive Agents; Infliximab; Methotrexate; Sarcoidosis; Treatment Outcome; Tumor Necrosis Factor-alpha; Uveitis | 2015 |
Central neurotoxicity in cancer chemotherapy: pharmacogenetic insights.
Topics: Antineoplastic Agents; Apolipoproteins E; Blood-Brain Barrier; Central Nervous System Diseases; Humans; Metabolic Networks and Pathways; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Pharmacogenetics; Polymorphism, Genetic | 2011 |
Spinal cord disorders in patients with cancer.
Topics: Anemia, Pernicious; Central Nervous System Diseases; Encephalomyelitis; Humans; Infections; Methotrexate; Motor Neurons; Neoplasm Metastasis; Neoplasms; Nerve Degeneration; Neuromuscular Diseases; Paraneoplastic Syndromes; Radiation Injuries; Spinal Cord; Spinal Cord Diseases; Spinal Cord Injuries | 1984 |
Methotrexate. II. Use in pediatric chemotherapy.
Topics: Administration, Oral; Central Nervous System; Central Nervous System Diseases; Child; DNA; Drug Therapy, Combination; Humans; Infusions, Parenteral; Injections, Spinal; Kinetics; Leucovorin; Leukemia; Methotrexate | 1984 |
[Neurological problems in malignant hemopathies in children. II. Neurotoxicity of antiblastic drugs and radiotherapy].
Topics: Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Humans; Infant; Leukemia; Lymphoma; Methotrexate; Radiotherapy; Vincristine | 1982 |
[Neuroleukemia--prophylaxis and treatment].
Topics: Central Nervous System Diseases; Humans; Leukemia, Lymphoid; Methotrexate; Prognosis | 1982 |
[Toxic lesions caused by cytostatic drugs].
Topics: Alopecia; Antineoplastic Agents; Arrhythmias, Cardiac; Blood Platelets; Blood Transfusion; Bone Marrow; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Diarrhea; Digestive System; Doxorubicin; Female; Hair; Humans; Kidney Diseases; Lung; Male; Methotrexate; Methotrimeprazine; Mutation; Pericarditis; Pregnancy; Pulmonary Fibrosis; Thrombocytopenia; Vincristine | 1980 |
[Neurotoxicity of antineoplastic antimetabolites and antineoplastic antibiotics].
Topics: Acute Disease; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Central Nervous System Diseases; Combined Modality Therapy; Humans; Methotrexate; Peripheral Nervous System Diseases; Radiotherapy | 1999 |
The effects of cancer therapy on the nervous system.
Topics: Acute Disease; Antineoplastic Agents; Brain Diseases; Central Nervous System Diseases; Child; Child, Preschool; Chronic Disease; Humans; Methotrexate; Neoplasms; Peripheral Nervous System Diseases; Radiotherapy; Spinal Cord Diseases; Time Factors; Vincristine | 1978 |
Chemotherapy of non-Hodgkin lymphoma: the diffuse types.
Topics: Antineoplastic Agents; Central Nervous System Diseases; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Humans; Leucovorin; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; Vincristine | 1978 |
Neurotoxicities of current leukemia therapy.
Topics: Antineoplastic Agents; Bone Marrow; Brain Diseases; Central Nervous System Diseases; Child, Preschool; Humans; Infant; Injections, Intravenous; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Methotrexate; Nervous System; Radiation Injuries; Radiotherapy; Spinal Puncture | 1979 |
Late side effects of treatment: skeletal, genetic, central nervous system, and oncogenic.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antineoplastic Agents; Busulfan; Carcinogens; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Female; Heart Diseases; Humans; Lung Diseases; Male; Menstruation Disturbances; Mercaptopurine; Methotrexate; Neoplasms; Neoplasms, Radiation-Induced; Pregnancy; Radiotherapy; Urinary Bladder Diseases | 1976 |
The definitive treatment of children with acute leukemia.
Topics: Asparaginase; Central Nervous System Diseases; Child; Cyclophosphamide; Daunorubicin; Drug Therapy, Combination; Humans; Immunotherapy; Infections; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms, Multiple Primary; Prednisone; Psychology; Remission, Spontaneous; Vincristine | 1976 |
Current pharmacological treatment approaches to central nervous system leukaemia.
Topics: Adolescent; Adult; Antineoplastic Agents; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Drug Evaluation; Humans; Infant; Infant, Newborn; Leukemia; Meningeal Neoplasms; Methotrexate | 1991 |
Methotrexate and childhood leukemia.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 1991 |
Radiotherapy vs intrathecal chemotherapy for CNS prophylaxis in childhood ALL.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Combined Modality Therapy; Humans; Injections, Spinal; Methotrexate; Nervous System Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Long-term sequelae of cancer treatment on the central nervous system in childhood.
Topics: Antineoplastic Agents; Central Nervous System Diseases; Child; Child, Preschool; Combined Modality Therapy; Humans; Leukemia, Lymphoid; Methotrexate; Radiotherapy; Risk Factors | 1987 |
Chemotherapy of childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Patient Compliance; Prednisone; Vincristine | 1986 |
Treatment of acute lymphoid leukemia in children: current regimens and future prospects.
Topics: Adolescent; Animals; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Mice; Prognosis; Recurrence; T-Lymphocytes | 1986 |
Treatment of acute lymphoblastic leukemia.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Cytopathogenic Effect, Viral; Daunorubicin; Humans; Kinetics; Leukemia, Experimental; Leukemia, Lymphoid; Meninges; Mercaptopurine; Methotrexate; Mice; Oncogenic Viruses; Patient Care Team; Remission, Spontaneous; Reverse Transcriptase Inhibitors; RNA Viruses; RNA-Directed DNA Polymerase; Time Factors; Vincristine | 1972 |
Treatment of acute leukemia.
Topics: Asparaginase; Bacterial Infections; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Synergism; Hemorrhage; Humans; Immunotherapy; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Mitosis; Neoplasms, Nerve Tissue; Prednisone; Remission, Spontaneous; Testicular Neoplasms; Uric Acid; Vincristine | 1972 |
Immunosuppressive therapy in neurological diseases.
Topics: Adrenocorticotropic Hormone; Azathioprine; Central Nervous System Diseases; Cyclophosphamide; Cytarabine; Encephalitis; Female; Humans; Hydrocortisone; Immunity, Cellular; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Lymphocyte Activation; Methotrexate; Multiple Sclerosis; Myasthenia Gravis; Myositis; Neuritis; Polyradiculopathy; Prednisone; Virus Diseases | 1974 |
[New principles of treatment in acute leukemia].
Topics: Adolescent; Adult; Antineoplastic Agents; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Female; Guanidines; Humans; Hydroxyurea; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Nitroso Compounds; Prednisone; Thrombocytopenia; Urea; Uric Acid; Vincristine | 1970 |
28 trial(s) available for methotrexate and Central Nervous System Diseases
| Article | Year |
|---|---|
Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01.
Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Central Nervous System Neoplasms; Child; Child, Preschool; Cranial Irradiation; Cytarabine; Female; Glucocorticoids; Humans; Hydrocortisone; Infant; Injections, Spinal; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Effect of isolated central nervous system leukaemia on bone marrow remission and survival in childhood acute lymphoblastic leukaemia. A report for Children's Cancer Study Group.
Topics: Adolescent; Bone Marrow; Brain Neoplasms; Central Nervous System Diseases; Child; Clinical Trials as Topic; Humans; Leukemia, Lymphoid; Methotrexate; Radiotherapy, High-Energy; Random Allocation; Remission, Spontaneous; Risk; Spinal Cord Diseases | 1981 |
Methotrexate systemic clearance influences probability of relapse in children with standard-risk acute lymphocytic leukaemia.
Topics: Bone Marrow Examination; Central Nervous System Diseases; Child; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Kinetics; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Probability; Random Allocation; Recurrence; Testicular Neoplasms | 1984 |
Prognostic factors and therapy in acute lymphoblastic leukemia of childhood: CCG-141. A report from childrens cancer study group.
Topics: Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Brain Neoplasms; Central Nervous System Diseases; Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Prednisone; Probability; Prognosis; Random Allocation; Testicular Neoplasms; Vincristine | 1983 |
Comparison of intermediate-dose methotrexate with cranial irradiation for the post-induction treatment of acute lymphocytic leukemia in children.
Topics: Adolescent; Adult; Brain; Central Nervous System Diseases; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Radiotherapy Dosage; Random Allocation; Time Factors | 1983 |
[Prophylactic CNS therapy in childhood leukemia--randomized controlled study of high-dose intravenous methotrexate and cranial irradiation].
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Leukemia, Lymphoid; Male; Methotrexate | 1982 |
Chemoimmunotherapy with Corynebacterium parvum in acute myelocytic leukemia.
Topics: Adolescent; Adult; Antineoplastic Agents; Central Nervous System Diseases; Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Immunotherapy; Infant; Infant, Newborn; Injections, Spinal; Leukemia, Myeloid, Acute; Methotrexate; Middle Aged; Propionibacterium acnes; Remission, Spontaneous; Time Factors | 1980 |
Moderate dose methotrexate, vincristine, asparaginase, and dexamethasone for treatment of adult acute lymphocytic leukemia.
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Clinical Trials as Topic; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Vincristine | 1982 |
Aminophylline for methotrexate-induced neurotoxicity.
Topics: Adenosine; Adolescent; Aminophylline; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1995 |
Comparison of two schedules of intermediate-dose methotrexate and cytarabine consolidation therapy for childhood B-precursor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Female; Humans; Infant; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; United States | 1994 |
Extended triple intrathecal chemotherapy trial for prevention of CNS relapse in good-risk and poor-risk patients with B-progenitor acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Diseases; Cyclophosphamide; Cytarabine; Dose-Response Relationship, Drug; Humans; Hydrocortisone; Injections, Spinal; Leukemic Infiltration; Mercaptopurine; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Vincristine | 1993 |
Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy--a Pediatric Oncology Group study.
Topics: Acute Disease; Administration, Oral; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Injections, Spinal; Leucovorin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Tomography, X-Ray Computed | 1998 |
Radiotherapy at tumor recurrence in primary CNS lymphoma.
Topics: Adult; Central Nervous System Diseases; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Lymphoma; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies | 1998 |
Low-dose weekly methotrexate for progressive neuropsychiatric manifestations in Behcet's disease.
Topics: Aged; Behcet Syndrome; Central Nervous System Diseases; Dementia; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged | 1998 |
Importance of radiotherapy in the outcome of patients with primary CNS lymphoma: an analysis of the CHOD/BVAM regimen followed by two different radiotherapy treatments.
Topics: Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Central Nervous System Diseases; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Radiotherapy Dosage; Spain; Survival Rate; United Kingdom; Vincristine | 2002 |
Evaluation of intensification and maintenance programs in the treatment of acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Prognosis; Radiotherapy, High-Energy; Remission, Spontaneous; Risk; Time Factors; Vincristine | 1978 |
Prophylactic CNS therapy in childhood acute leukemia: review of methods used.
Topics: Antineoplastic Agents; Catheters, Indwelling; Central Nervous System; Central Nervous System Diseases; Child; Clinical Trials as Topic; Cytarabine; Drug Therapy, Combination; Humans; Hydrocortisone; Injections, Intraventricular; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Methotrexate; Radiotherapy; Radiotherapy Dosage; Time Factors | 1979 |
The current status of the treatment of childhood acute lymphoblastic leukemia.
Topics: Acute Disease; Age Factors; Animals; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Infant; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1976 |
The m-BACOD combination chemotherapy regimen in large-cell lymphoma: analysis of the completed trial and comparison with the M-BACOD regimen.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Diseases; Clinical Trials as Topic; Cyclophosphamide; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Follow-Up Studies; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Recurrence, Local; Prognosis; Remission Induction; Survival Analysis; Time Factors; Vincristine | 1990 |
Low-dose chemotherapy with central nervous system prophylaxis and zidovudine maintenance in AIDS-related lymphoma. A prospective multi-institutional trial.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Central Nervous System Diseases; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Follow-Up Studies; HIV Seropositivity; Humans; Leucovorin; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Opportunistic Infections; Prospective Studies; Vincristine; Zidovudine | 1991 |
Current pharmacological treatment approaches to central nervous system leukaemia.
Topics: Adolescent; Adult; Antineoplastic Agents; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Drug Evaluation; Humans; Infant; Infant, Newborn; Leukemia; Meningeal Neoplasms; Methotrexate | 1991 |
Isolated central nervous system relapse in acute lymphocytic leukemia (ALL) in children. Experiences of the Swiss Pediatric Oncology Group (SPOG/SAKK) 1976-1986.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Female; Humans; Hydrocortisone; Infant; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Switzerland | 1988 |
A long-term prospective study of the use of methotrexate in rheumatoid arthritis. Update after a mean of fifty-three months.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Central Nervous System Diseases; Clinical Trials as Topic; Gastrointestinal Diseases; HLA Antigens; Humans; Leukopenia; Methotrexate; Middle Aged; Mouth; Pain; Phenotype; Prospective Studies; Time Factors | 1988 |
Comparison of two methods of preventing central nervous system leukemia.
Topics: Adolescent; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Cobalt Isotopes; Cyclophosphamide; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Prednisone; Recurrence; Vincristine | 1973 |
Prevention of central nervous system leukemia by irradiation.
Topics: Brain; Cell Count; Central Nervous System; Central Nervous System Diseases; Child; Cytodiagnosis; Diagnosis, Differential; Humans; Leukemia, Lymphoid; Methotrexate; Radiation Effects; Radiotherapy; Radiotherapy Dosage; Remission, Spontaneous; Spinal Cord | 1973 |
Acute lymphocytic leukemia in childhood.
Topics: Asparaginase; Black People; Bone Marrow Examination; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunosuppression Therapy; Infections; Injections, Spinal; Leukemia, Lymphoid; Leukopenia; Male; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1974 |
Clinical trials of the acute leukemia group B in acute lymphocytic leukemia of childhood.
Topics: Adolescent; Asparaginase; Bone Marrow Examination; Central Nervous System Diseases; Child; Child, Preschool; Daunorubicin; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1973 |
Treatment of acute lymphoblastic leukaemia: effect of "prophylactic" therapy against central nervous system leukaemia. Report ot the Medical Research Council by the Leukaemia Committee and the Working Party on Leukaemia in Childhood.
Topics: Adolescent; Blood Cell Count; Blood Platelets; Central Nervous System Diseases; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant; Leukemia, Lymphoid; Leukocyte Count; Methotrexate; Radiotherapy Dosage; Remission, Spontaneous; Time Factors | 1973 |
174 other study(ies) available for methotrexate and Central Nervous System Diseases
| Article | Year |
|---|---|
Neurosarcoidosis of the Cauda Equina: Clinical Course, Radiographic and Electrodiagnostic Findings, Response to Treatment, and Outcomes.
Topics: Cauda Equina; Central Nervous System Diseases; Female; Humans; Hypesthesia; Male; Methotrexate; Retrospective Studies; Sarcoidosis | 2022 |
Central nervous system graft-versus-host disease in a 68-year-old man presenting with myoclonus.
Topics: Aged; Brain Diseases; Central Nervous System Diseases; Glucocorticoids; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Leukemia, Large Granular Lymphocytic; Magnetic Resonance Imaging; Male; Methotrexate; Methylprednisolone; Myelodysplastic Syndromes; Myoclonus; Pulse Therapy, Drug; Transplantation, Homologous | 2019 |
Neurosarcoidosis and multiple intracerebral hematomas: An unusual clinical presentation.
Topics: Anti-Inflammatory Agents; Anticonvulsants; Central Nervous System Diseases; Cerebral Hemorrhage; Female; Hematoma; Humans; Lamotrigine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methotrexate; Methylprednisolone; Middle Aged; Neuroimaging; Prednisone; Sarcoidosis | 2017 |
The Diagnosis and Treatment of Primary CNS Lymphoma.
Topics: Adult; Aged; Central Nervous System Diseases; Combined Modality Therapy; Drug Therapy; Female; Germany; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Prognosis; Rituximab | 2018 |
An atypical isolated CNS blast crisis in chronic myeloid leukaemia.
Topics: Aged; Antineoplastic Agents; Blast Crisis; Brain; Central Nervous System Diseases; Cytarabine; Glucocorticoids; Humans; Image Enhancement; Imatinib Mesylate; Immunosuppressive Agents; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Magnetic Resonance Imaging; Maintenance Chemotherapy; Male; Methotrexate; Neuroimaging; Spinal Cord; Treatment Outcome | 2018 |
Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease.
Topics: Adult; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Cytarabine; Humans; Hydrocortisone; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2019 |
Multiple cerebral infarcts: a rare complication of neurosarcoidosis.
Topics: Adrenal Cortex Hormones; Central Nervous System Diseases; Cerebral Infarction; Humans; Hydrocephalus; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Sarcoidosis; Stroke | 2019 |
Infliximab biosimilar for treating neurosarcoidosis: tolerance and efficacy in a retrospective study including switch from the originator and initiation of treatment.
Topics: Adult; Antirheumatic Agents; Azathioprine; Biosimilar Pharmaceuticals; Central Nervous System Diseases; Drug Substitution; Female; Follow-Up Studies; Humans; Infliximab; Male; Methotrexate; Middle Aged; Retrospective Studies; Sarcoidosis; Statistics, Nonparametric; Treatment Outcome | 2019 |
Brentuximab Vedotin and High-dose Methotrexate Administrated Alternately for Refractory Anaplastic Large-cell Lymphoma With Central Nervous System Disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brentuximab Vedotin; Central Nervous System Diseases; Child; Humans; Lymphoma, Large-Cell, Anaplastic; Male; Methotrexate; Neoplasm Recurrence, Local; Prognosis | 2020 |
[Dysphonia as a symptom of sarcoidosis].
Topics: Adrenal Cortex Hormones; Biopsy; Central Nervous System Diseases; Drug Therapy, Combination; Dysphonia; Humans; Laryngeal Diseases; Laryngoscopy; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Sarcoidosis; Sarcoidosis, Pulmonary; Secondary Prevention; Tomography, X-Ray Computed; Vocal Cords | 2014 |
50 years ago in the Journal of Pediatrics: central nervous system complications of children with acute leukemia: an evaluation of treatment methods.
Topics: Central Nervous System Diseases; Child; Evaluation Studies as Topic; History, 20th Century; Humans; Injections, Spinal; Methotrexate; Periodicals as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; United States | 2014 |
Neurosarcoidosis mimicking multiple sclerosis successfully treated with methotrexate and adalimumab.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Central Nervous System Diseases; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Multiple Sclerosis; Predictive Value of Tests; Remission Induction; Sarcoidosis; Treatment Outcome | 2014 |
Spinal sarcoidosis presenting with epiconus syndrome.
Topics: Aged; Anti-Inflammatory Agents; Central Nervous System Diseases; Humans; Immunosuppressive Agents; Lumbar Vertebrae; Male; Methotrexate; Methylprednisolone; Sarcoidosis; Spinal Cord Diseases; Syndrome; Thoracic Vertebrae | 2014 |
A case of relapsing neurosarcoidosis with brain nodules and hydrocephalus successfully treated by corticosteroid and methotrexate.
Topics: Adrenal Cortex Hormones; Central Nervous System Diseases; Cognition Disorders; Comorbidity; Drug Therapy, Combination; Female; Humans; Hydrocephalus; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Recurrence; Rheumatic Nodule; Sarcoidosis; Treatment Outcome | 2015 |
Temozolomide for central nervous system involvement in mycosis fungoides.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Dacarbazine; Dexamethasone; Female; Humans; Male; Methotrexate; Middle Aged; Mycosis Fungoides; Retreatment; Skin Neoplasms; Temozolomide; Treatment Outcome | 2016 |
Islands of Inflammation: Neurosarcoidosis.
Topics: Adult; Blood Sedimentation; C-Reactive Protein; Central Nervous System Diseases; Glucocorticoids; Humans; Hypesthesia; Immunosuppressive Agents; Low Back Pain; Lumbar Vertebrae; Lymphadenopathy; Male; Methotrexate; Neurologic Examination; Prednisone; Sarcoidosis | 2017 |
Treatment of neurosarcoidosis: A comparative study of methotrexate and mycophenolate mofetil.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Central Nervous System Diseases; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Recurrence; Retrospective Studies; Sarcoidosis; Treatment Outcome; Young Adult | 2016 |
Long-term outcomes of refractory neurosarcoidosis treated with infliximab.
Topics: Adult; Aged; Antirheumatic Agents; Central Nervous System Diseases; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Infliximab; Longitudinal Studies; Male; Methotrexate; Middle Aged; Retrospective Studies; Sarcoidosis; Severity of Illness Index; Treatment Outcome | 2017 |
[Bing-Neel syndrome revealing Waldenström's macroglobulinemia].
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone and Bones; Central Nervous System Diseases; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Humans; Magnetic Resonance Imaging; Male; Meningitis; Methotrexate; Middle Aged; Neoplasm Invasiveness; Nervous System Neoplasms; Polyradiculopathy; Prednisone; Rituximab; Spinal Nerve Roots; Syndrome; Vincristine; Waldenstrom Macroglobulinemia | 2010 |
Isolated central nervous system posttransplant lymphoproliferative disorder treated with high-dose intravenous methotrexate.
Topics: Central Nervous System Diseases; Epstein-Barr Virus Infections; Humans; Immunosuppressive Agents; Injections, Intravenous; Kidney Transplantation; Methotrexate; Myeloproliferative Disorders; Postoperative Complications; Transplantation, Homologous; Treatment Outcome | 2009 |
Response: Intrathecal methotrexate and central nervous system events.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Humans; Immunotherapy; Injections, Spinal; Lymphoma, Large-Cell, Anaplastic; Methotrexate; Prednisone; Prognosis; Research Design; Risk; Treatment Outcome; Vincristine | 2009 |
Intrathecal MTX for DLBCL: from an inappropriate prophylactic tradition to a medical error?
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Humans; Immunotherapy; Injections, Spinal; Lymphoma, Large B-Cell, Diffuse; Medical Errors; Methotrexate; Prednisone; Research Design; Risk; Treatment Outcome; Vincristine | 2009 |
Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Electroencephalography; Female; Humans; Infant; Leukemic Infiltration; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Tomography, X-Ray Computed; Vincristine | 2010 |
[Imaging findings and differentials in neurosarcoidosis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Brain; Brain Diseases; Central Nervous System Diseases; Cortisone; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Methotrexate; Neurologic Examination; Sarcoidosis; Tomography, X-Ray Computed | 2010 |
Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients.
Topics: Adrenal Cortex Hormones; Adult; Age of Onset; Aged; Central Nervous System Diseases; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Peptidyl-Dipeptidase A; Retrospective Studies; Sarcoidosis; Spinal Cord Diseases; Young Adult | 2011 |
Diagnostic and therapeutic challenges.
Topics: Adult; Amiodarone; Central Nervous System Diseases; Diagnosis, Differential; Glucocorticoids; Humans; Intraocular Pressure; Male; Methotrexate; Optic Disk; Papilledema; Prednisone; Sarcoidosis; Vasodilator Agents; Vision Disorders; Visual Acuity; Visual Fields | 2011 |
Intraventricular rituximab and systemic chemotherapy for treatment of central nervous system post-transplant lymphoproliferative disorder after kidney transplantation.
Topics: Adolescent; Adult; Antibodies, Monoclonal, Murine-Derived; B-Lymphocytes; Central Nervous System Diseases; Dexamethasone; Drug Therapy, Combination; Epstein-Barr Virus Infections; Fatal Outcome; Herpesvirus 4, Human; Humans; Immunologic Factors; Infusions, Intraventricular; Kidney Transplantation; Lymphoproliferative Disorders; Magnetic Resonance Imaging; Male; Methotrexate; Postoperative Complications; Prognosis; Rituximab; Seizures; Treatment Outcome | 2012 |
Methotrexate-related nonnecrotizing multifocal axonopathy detected by beta-amyloid precursor protein immunohistochemistry.
Topics: Amyloid beta-Protein Precursor; Antimetabolites, Antineoplastic; Axons; Central Nervous System Diseases; Granuloma; Humans; Immunohistochemistry; Liver Diseases; Methotrexate; Transfusion Reaction | 2002 |
CENTRAL NERVOUS SYSTEM COMPLICATIONS OF CHILDREN WITH ACUTE LEUKEMIA. AN EVALUATION OF TREATMENT METHODS.
Topics: Brain Diseases; Central Nervous System Diseases; Child; Humans; Leukemia; Meninges; Methotrexate; Neoplasms; Neurologic Manifestations; Prognosis; Spinal Cord; Spinal Puncture | 1964 |
CENTRAL NERVOUS SYSTEM INVOLVEMENT BY LEUKEMIA IN CHILDREN. II. THERAPY WITH INTRATHECAL METHOTREXATE.
Topics: Central Nervous System Diseases; Cerebrospinal Fluid Proteins; Child; Drug Therapy; Glucose; Humans; Injections; Injections, Spinal; Intracranial Pressure; Leukemia; Leukocyte Count; Methotrexate; Neoplasms; Spinal Puncture; Toxicology | 1965 |
CENTRAL NERVOUS SYSTEM INVOLVEMENT BY LEUKEMIA IN CHILDREN. I. RELATIONSHIP TO SYSTEMIC LEUKEMIA AND DESCRIPTION OF CLINICAL AND LABORATORY MANIFESTATIONS.
Topics: Antineoplastic Agents; Central Nervous System Diseases; Child; Clinical Laboratory Techniques; Drug Therapy; Headache; Humans; Intracranial Pressure; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Papilledema; Prednisone; Vomiting | 1965 |
[LEUKEMIC MENINGEAL DISEASE IN A PATIENT WITH HEMATOLOGICAL REMISSION SUCCESSFULLY TREATED WITH INTRATHECAL AMETHOPTERIN].
Topics: Central Nervous System Diseases; Child; Drug Therapy; Humans; Leukemia; Meninges; Methotrexate | 1965 |
Long-term outcomes of allogeneic stem cell transplant recipients after calcineurin inhibitor-induced neurotoxicity.
Topics: Adult; Bone Marrow Diseases; Bone Marrow Transplantation; Brain; Calcineurin Inhibitors; Central Nervous System Diseases; Cyclosporine; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prednisone; Retrospective Studies; Tacrolimus; Transplantation, Homologous | 2003 |
A novel CIAS1 mutation and plasma/cerebrospinal fluid cytokine profile in a German patient with neonatal-onset multisystem inflammatory disease responsive to methotrexate therapy.
Topics: Arthralgia; Carrier Proteins; Central Nervous System Diseases; Child; Chronic Disease; Cytokines; DNA Mutational Analysis; Glucocorticoids; Humans; Immunosuppressive Agents; Inflammation; Male; Meningitis; Methotrexate; Mutation, Missense; NLR Family, Pyrin Domain-Containing 3 Protein; Optic Nerve Diseases; Syndrome; Urticaria | 2004 |
Cauda equina and conus medullaris syndrome in sarcoidosis.
Topics: Anti-Inflammatory Agents; Central Nervous System Diseases; Electrodiagnosis; Electromyography; Female; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Muscle Weakness; Neural Conduction; Neurologic Examination; Polyradiculopathy; Prednisone; Sarcoidosis; Spinal Cord Compression | 2005 |
Treatment of severe disseminated juvenile systemic xanthogranuloma with multiple lesions in the central nervous system.
Topics: Central Nervous System Diseases; Combined Modality Therapy; Craniotomy; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant; Injections, Spinal; Liver Diseases; Lung Diseases; Mercaptopurine; Methotrexate; Paresis; Prednisolone; Skin Diseases; Vinblastine; Xanthogranuloma, Juvenile | 2006 |
[Complications in the central nervous system during chemotherapy for childhood acute lymphoblastic leukemia: JACLS ALL-02 study].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Japan; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors | 2007 |
Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis.
Topics: Antineoplastic Agents; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Clinical Protocols; Cohort Studies; Dexamethasone; Etoposide; Female; Humans; Infant; Lymphohistiocytosis, Hemophagocytic; Magnetic Resonance Imaging; Male; Methotrexate; Proportional Hazards Models; Seizures; Stem Cell Transplantation; Survival Rate; Tomography, X-Ray Computed | 2008 |
Neurotoxicity of antineoplastic drugs.
Topics: Altretamine; Antineoplastic Agents; Asparaginase; Brain; Central Nervous System Diseases; Cisplatin; Cranial Nerves; Humans; Injections, Intraventricular; Injections, Spinal; Methotrexate; Peripheral Nervous System Diseases; Procarbazine; Risk; Tomography, X-Ray Computed; Vinca Alkaloids | 1982 |
CT abnormalities and altered methotrexate clearance in children with CNS leukemia.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Leukemia; Methotrexate; Statistics as Topic; Tomography, X-Ray Computed | 1984 |
[Results of modified LSA2L2 therapy in children with non-Hodgkin's lymphoma].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Lymphoma; Male; Methotrexate; Neoplasm Invasiveness; Prednisone; Vincristine | 1984 |
Evaluation of the LSA2L2 protocol for treatment of childhood non-Hodgkin's lymphoma. A report from the Polish Children's Leukemia/Lymphoma Study Group.
Topics: Abdominal Neoplasms; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Leukopenia; Lymphoma; Male; Mediastinal Neoplasms; Methotrexate; Neoplasm Staging; Prednisone; Prognosis; Vincristine | 1984 |
An adult case of chronic myelogenous leukemia with myeloblastic involvement of the central nervous system.
Topics: Adult; Candidiasis; Central Nervous System Diseases; Female; Humans; Injections, Spinal; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Meningeal Neoplasms; Methotrexate | 1984 |
Outcome following late marrow relapse in childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Marrow Diseases; Brain; Central Nervous System Diseases; Child; Combined Modality Therapy; Drug Administration Schedule; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Recurrence; Spinal Cord; Testicular Neoplasms; Time Factors | 1984 |
High dose systemic methotrexate-associated acute neurologic dysfunction.
Topics: Adolescent; Brain; Central Nervous System Diseases; Child; Female; Femoral Neoplasms; Humans; Leucovorin; Methotrexate; Osteosarcoma; Tomography, X-Ray Computed | 1983 |
Patterns of treatment failure in Burkitt's lymphoma.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Dexamethasone; Drug Resistance; Drug Therapy, Combination; Humans; Methotrexate; Time Factors; Vincristine | 1983 |
Paraparesis following intrathecal chemotherapy.
Topics: Animals; Benzyl Alcohols; Central Nervous System Diseases; Cytarabine; Female; Humans; Injections, Spinal; Male; Methotrexate; Middle Aged; Paraplegia; Rats; Rats, Inbred Strains | 1983 |
Central nervous system workshop.
Topics: Animals; Antineoplastic Agents; Central Nervous System; Central Nervous System Diseases; Haplorhini; Humans; Intelligence; Methotrexate; Neoplasms; Radiation Injuries; Radiotherapy; Time Factors | 1981 |
[Analysis of prophylactic treatment of central nervous system leukemia in children (author's transl)].
Topics: Adolescent; Antineoplastic Agents; Central Nervous System Diseases; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Injections, Spinal; Leukemia; Male; Methotrexate; Prednisone; Vincristine | 1980 |
Computed tomography brain scans in children with acute lymphocytic leukemia receiving methotrexate alone as central nervous system prophylaxis.
Topics: Adolescent; Brain; Brain Diseases; Central Nervous System Diseases; Child; Child, Preschool; Humans; Infant; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Remission, Spontaneous; Time Factors; Tomography, X-Ray Computed | 1980 |
Changes of CSF-protein pattern in children with acute lymphoblastic leukemia during prophylactic CNS therapy (Berlin protocol).
Topics: Antineoplastic Agents; Central Nervous System Diseases; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Drug Therapy, Combination; Electrophoresis, Agar Gel; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Skull | 1980 |
Life-threatening neuropathy and hepatotoxicity in infants during induction therapy for acute lymphoblastic leukemia.
Topics: Asparaginase; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Retrospective Studies; Vincristine | 1981 |
Intermediate dose methotrexate (IDM) in childhood acute lymphocytic leukaemia in Norway. Report on a national treatment program.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphoid; Male; Methotrexate; Norway; Testicular Neoplasms | 1981 |
[Effects of prophylactic treatment of central nervous system leukemia in children. Analysis of CNS prophylactic treatment with cyclic high dose multichemotherapy, craniospinal irradiation, and high dose infusion of MTX].
Topics: Adolescent; Brain; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Neoplasm Invasiveness; Radiotherapy Dosage; Spinal Cord | 1982 |
Methotrexate/L-asparaginase combination chemotherapy for patients with acute leukemia in relapse: a study of 36 children.
Topics: Acute Disease; Adolescent; Asparaginase; B-Lymphocytes; Central Nervous System Diseases; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Prognosis; T-Lymphocytes | 1980 |
Lymphoblastic lymphoma in adults: results of a pilot protocol.
Topics: Adolescent; Adult; Asparaginase; Central Nervous System Diseases; Cyclophosphamide; Doxorubicin; Female; Humans; Leucovorin; Leukemia, Myeloid; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine | 1981 |
Absence of predictive parameters for CNS involvement in adult non-lymphocytic leukaemia at time of diagnosis.
Topics: Adult; Central Nervous System Diseases; Cytarabine; Female; Fever; Hepatomegaly; Humans; Leukemia; Lymph Nodes; Male; Methotrexate; Middle Aged; Splenomegaly | 1982 |
Dementia and central nervous system involvement in chronic lymphocytic leukaemia.
Topics: Central Nervous System Diseases; Dementia; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged | 1982 |
Extramedullary blast transformation in the central nervous system in idiopathic myelofibrosis.
Topics: Central Nervous System Diseases; Cerebrospinal Fluid; Dexamethasone; Humans; Male; Methotrexate; Middle Aged; Myeloproliferative Disorders; Phenytoin; Primary Myelofibrosis; Tomography, X-Ray Computed; X-Rays | 1981 |
[Pharmacokinetics and intraventricular therapy with methotrexate via Ommaya reservoir for central nervous system leukemia (author's transl)].
Topics: Central Nervous System Diseases; Child; Female; Humans; Injections, Intraventricular; Kinetics; Leukemia; Methotrexate | 1980 |
Central nervous system involvement in systemic lupus erythematosus: a new therapeutic approach with intrathecal dexamethasone and methotrexate.
Topics: Adolescent; Adult; Central Nervous System Diseases; Dexamethasone; Drug Combinations; Female; Humans; Injections, Spinal; Lupus Erythematosus, Systemic; Methotrexate; Middle Aged | 1994 |
Toxicity of CNS prophylaxis for childhood leukemia.
Topics: Antimetabolites, Antineoplastic; Central Nervous System Diseases; Child; Cognition; Cranial Irradiation; Female; Growth; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1997 |
Severe central nervous adverse effect of intrathecal chemotherapy in a 16-yr-old patient with Burkitt's type lymphoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Burkitt Lymphoma; Central Nervous System Diseases; Cyclophosphamide; Cytarabine; Dexamethasone; Electroencephalography; Humans; Ifosfamide; Injections, Spinal; Male; Methotrexate; Neoplasm Staging; Prednisolone; Tomography, X-Ray Computed; Vincristine | 1997 |
Diagnosis and management of neurological sarcoidosis.
Topics: Central Nervous System Diseases; Chronic Disease; Cyclophosphamide; Humans; Immunosuppressive Agents; Methotrexate; Prednisone; Sarcoidosis; Treatment Outcome | 1997 |
Proton magnetic resonance spectroscopy ((1)H-MRS) of the brain following high-dose methotrexate treatment for childhood cancer.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Brain; Case-Control Studies; Central Nervous System Diseases; Child; Female; Humans; Leukemia; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate | 2000 |
Drugs for rheumatoid arthritis.
Topics: Administration, Oral; Adrenal Cortex Hormones; Anorexia; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Central Nervous System Diseases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Gold Sodium Thiomalate; Humans; Hydroxychloroquine; Methotrexate; Nausea; Osteoporosis; Plasmapheresis; Prednisone; Sulfasalazine; Tumor Necrosis Factor-alpha | 2000 |
Methotrexate treatment protocols and the central nervous system: significant cure with significant neurotoxicity.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Electroencephalography; Female; Humans; Leucovorin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, Emission-Computed, Single-Photon | 2000 |
Acute neurotoxicity in children with B-lineage acute lymphoblastic leukemia (B-ALL) treated with intermediate risk protocols.
Topics: Adolescent; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Diseases; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Disease-Free Survival; Female; Humans; Hydrocortisone; Incidence; Infant; Injections, Spinal; Italy; Male; Methotrexate; Radiotherapy, Adjuvant; Retrospective Studies | 2000 |
[Low-dose weekly methotrexate therapy for progressive neuro-Behçet's disease].
Topics: Behcet Syndrome; Brain; Central Nervous System Diseases; Dementia; Drug Administration Schedule; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Pulse Therapy, Drug | 1999 |
Toxicity of methotrexate treatment in psoriasis and psoriatic arthritis--short- and long-term toxicity in 104 patients.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Psoriatic; Central Nervous System Diseases; Child; Drug Interactions; Enzyme Inhibitors; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Time Factors; Transaminases | 2001 |
Methotrexate-related nonnecrotizing multifocal axonopathy detected by beta-amyloid precursor protein immunohistochemistry.
Topics: Amyloid beta-Protein Precursor; Antimetabolites, Antineoplastic; Axons; Central Nervous System Diseases; Female; Humans; Immunohistochemistry; Injections, Spinal; Leukemia; Methotrexate; Middle Aged | 2002 |
Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999.
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Central Nervous System Diseases; Chi-Square Distribution; Disease-Free Survival; Female; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Injections, Spinal; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Survival Rate; United Kingdom | 2002 |
Weekly methotrexate-calcium leucovorin rescue: effect of alkalinization on nephrotoxicity; pharmacokinetics in the CNS; and use in CNS non-Hodgkin's lymphoma.
Topics: Adult; Aged; Bone Marrow; Central Nervous System Diseases; Creatinine; Drug Administration Schedule; Drug Therapy, Combination; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Kidney; Kinetics; Leucovorin; Lymphoma; Male; Methotrexate; Middle Aged; Urine | 1977 |
Experimental approaches to the treatment of CNS leukemia.
Topics: Animals; Antineoplastic Agents; Catheters, Indwelling; Central Nervous System Diseases; Dose-Response Relationship, Drug; Half-Life; Haplorhini; Humans; Injections, Intravenous; Injections, Intraventricular; Injections, Spinal; Leukemia, Experimental; Macaca mulatta; Methotrexate; Perfusion | 1979 |
Leukaemia in children.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Immunotherapy; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Vincristine | 1977 |
Antimetaboliths in the prophylaxis and treatment of central nervous system leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Central Nervous System Diseases; Child, Preschool; Cytarabine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infant; Injections; Injections, Intraventricular; Leukemia, Lymphoid; Lumbosacral Region; Male; Methotrexate | 1977 |
[Contribution to results of treatment of telecobalt irradiation of the CNS in acute lymphatic leukoses in childhood (author's transl)].
Topics: Central Nervous System Diseases; Child; Cobalt Radioisotopes; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Radioisotope Teletherapy | 1977 |
Combination chemotherapy for acute lymphoblastic leukaemia in adults.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Prednisolone; Remission, Spontaneous; Vincristine | 1978 |
Intraventricular versus intralumbar methotrexate for central-nervous-system leukemia: prolonged remission with the Ommaya reservoir.
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Humans; Injections, Intraventricular; Leukemia, Lymphoid; Methotrexate; Remission, Spontaneous; Spinal Puncture | 1979 |
Acute lymphoblastic leukemia with eosinophilia and basophilia.
Topics: Antineoplastic Agents; Basophils; Central Nervous System Diseases; Child, Preschool; Diagnosis, Differential; Eosinophilia; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytosis; Male; Methotrexate; Recurrence; Remission, Spontaneous | 1979 |
Intermediate dose methotrexate (IDM) in childhood acute lymphocytic leukemia (ALL).
Topics: Adolescent; Asparaginase; Brain Neoplasms; Central Nervous System Diseases; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Risk; Time Factors; Vincristine | 1979 |
Acute respiratory illness in children with acute lymphoblastic leukemia.
Topics: Central Nervous System Diseases; Humans; Immunosuppression Therapy; Leukemia, Lymphoid; Leukocyte Count; Mercaptopurine; Methotrexate; Pneumonia, Pneumocystis; Pulmonary Fibrosis | 1977 |
Use of the Ommaya reservoir in the prevention and treatment of CNS leukemia.
Topics: Adolescent; Antineoplastic Agents; Catheters, Indwelling; Central Nervous System Diseases; Cerebral Ventriculography; Child; Child, Preschool; Cytarabine; Female; Humans; Infant; Injections, Intraventricular; Leukemia, Lymphoid; Male; Methotrexate | 1979 |
Neuropsychologic follow-up study of children with acute lymphocytic leukemia. A preliminary report.
Topics: Adolescent; Brain; Central Nervous System Diseases; Child; Child, Preschool; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Injections, Intravenous; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Neurologic Examination; Psychological Tests; Radiotherapy; Remission, Spontaneous; Tomography, Emission-Computed | 1979 |
Long-term control of central nervous system leukaemia.
Topics: Central Nervous System Diseases; Child; Humans; Leukemia, Lymphoid; Long-Term Care; Methotrexate; Remission, Spontaneous | 1977 |
[Long-term follow up of central nervous system leukemia in children (author's transl)].
Topics: Central Nervous System Diseases; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydrocortisone; Infant; Leukemia; Male; Methotrexate; Time Factors | 1979 |
Antimetabolites in the central nervous system.
Topics: Animals; Antimetabolites, Antineoplastic; Central Nervous System; Central Nervous System Diseases; Cytarabine; Humans; Injections, Spinal; Leukemia; Methotrexate | 1977 |
[Preventive therapy of central nervous system leukemia in children: results of CNS-prophylaxis with intrathecal methotrexate and hydrocortisone (author's transl)].
Topics: Acute Disease; Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Leukemia; Male; Methotrexate | 1977 |
Clinical pharmacology of intrathecal methotrexate. II. An improved dosage regimen derived from age-related pharmacokinetics.
Topics: Adolescent; Adult; Age Factors; Body Surface Area; Central Nervous System Diseases; Child; Drug Administration Schedule; Humans; Injections, Spinal; Leukemia; Methotrexate | 1977 |
Encephalomyelopathy following intrathecal methotrexate treatment in a child with acute leukemia.
Topics: Acute Disease; Antineoplastic Agents; Brain; Central Nervous System Diseases; Child, Preschool; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia; Male; Methotrexate; Spinal Cord; Time Factors | 1978 |
[Prophylactic CNS-leukemia therapy with cyclic intrathecal methotrexate and hydrocortisone injection (author's transl)].
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Leukemia; Male; Methotrexate | 1979 |
Neurological complications of childhood leukaemia.
Topics: Adolescent; Bacterial Infections; Central Nervous System Diseases; Cerebral Hemorrhage; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Leukemia; Male; Methotrexate; Prognosis; Virus Diseases | 1977 |
Combined modality treatment of Burkitt's lymphoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Burkitt Lymphoma; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Prednisolone; Recurrence; Remission, Spontaneous; Time Factors; Vincristine | 1978 |
[Prophylaxis and therapy of neuro-meningeal involvement of acute lymphoblastic leukemia. Case reports and critical review of literature (author's transl)].
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Humans; Infant; Leukemia, Lymphoid; Methotrexate; Prednisolone | 1975 |
Adult central nervous system leukemia: incidence and clinicopathologic features.
Topics: Adolescent; Adult; Aged; Blood Platelets; Central Nervous System Diseases; Female; Humans; Leukemia; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Middle Aged; Radiotherapy, High-Energy; Remission, Spontaneous | 1976 |
Meningeal relapse after long-term remission in acute childhood lymphocytic leukemia.
Topics: Central Nervous System Diseases; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Remission, Spontaneous; Time Factors | 1976 |
Neurotoxicity due to CNS therapy for leukemia.
Topics: Adolescent; Brain Diseases; Central Nervous System Diseases; Child; Humans; Infections; Leukemia; Methotrexate; Paralysis; Radiotherapy; Spinal Cord Diseases | 1977 |
Combination chemotherapy in abdominal Burkitt's lymphoma.
Topics: Abdominal Neoplasms; Adolescent; Antineoplastic Agents; Burkitt Lymphoma; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Remission, Spontaneous; Vincristine | 1977 |
Chemotherapy of malignant histiocytosis in adults.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Central Nervous System Diseases; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Lymphatic Diseases; Male; Methotrexate; Middle Aged; Prednisone; Vincristine | 1977 |
Preventing central nervous system leukemia.
Topics: Animals; Brain; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Humans; Hydrocortisone; Injections, Spinal; Leukemia; Methotrexate; Recurrence; Spine; Time Factors | 1976 |
Treatment of meningeal leukemia.
Topics: Catheterization; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Injections, Intraventricular; Injections, Spinal; Leukemia; Methotrexate | 1976 |
[Electroencephalographic and neurological changes in children given intraspinal preventive treatment with amethopterin and methylprednisolone].
Topics: Central Nervous System Diseases; Child; Child, Preschool; Electroencephalography; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Methylprednisolone | 1975 |
Leukoencephalopathy following combined therapy of central nervous system leukemia and lymphoma.
Topics: Axons; Brain; Brain Diseases; Burkitt Lymphoma; Central Nervous System Diseases; Child; Cytarabine; Humans; Injections, Spinal; Leukemia, Lymphoid; Meninges; Methotrexate; Necrosis; Radiotherapy | 1975 |
Immunosuppression and immunostimulation in acute leukaemia.
Topics: Acute Disease; BCG Vaccine; Central Nervous System Diseases; Humans; Immunosuppression Therapy; Immunotherapy; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Lymphopenia; Mercaptopurine; Methotrexate; Neutropenia | 1975 |
IMFRA (intermittent intrathecal methotrexate and fractional radiation) plus chemotherapy in childhood leukemia.
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Dose-Response Relationship, Radiation; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Remission, Spontaneous | 1976 |
Chemotherapy of acute lymphoblastic leukemia in children.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Hydroxyurea; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate; Nitrosourea Compounds; Prednisone; Remission, Spontaneous; Thioguanine; Vincristine | 1976 |
Complications of intrathecal methotrexate prophylaxis and treatment of central nervous system leukemia in children.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1976 |
Spinal fluid cytology during chemotherapy of leukemia of the central nervous system in children.
Topics: Adolescent; Asparaginase; Autopsy; Blood Cell Count; Carcinoma; Cell Division; Central Nervous System Diseases; Cerebrospinal Fluid; Child, Preschool; Diagnosis, Differential; Female; Humans; Leukemia; Lymphoma; Male; Meninges; Methotrexate | 1975 |
Meningeal mycosis fungoides: clinical and cellular characteristics.
Topics: Animals; Cell Membrane; Cell Nucleus; Central Nervous System Diseases; Cerebrospinal Fluid; Cyclophosphamide; Humans; Immune Adherence Reaction; Immunoglobulins; Male; Meninges; Methotrexate; Microscopy, Electron; Middle Aged; Mycosis Fungoides; Neoplasms; Sheep | 1975 |
[Diagnosis and therapy of neoplastic meningosis].
Topics: Acute Disease; Central Nervous System Diseases; Cytarabine; Humans; Injections, Spinal; Leukemia; Meninges; Methotrexate; Mitolactol; Neoplasm Metastasis; Nitrosourea Compounds; Pyrimethamine; Radiotherapy | 1975 |
[Treatment of central nervous system leukemia in acute childhood leukemia. I. Results of intrathecal single or multiple drug combination therapy (author's transl)].
Topics: Acute Disease; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Leukemia; Male; Methotrexate | 1975 |
The BFM-protocol for HIV-negative Burkitt's lymphomas and L3 ALL in adult patients: a high chance for cure.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Diseases; Female; HIV Seropositivity; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 1992 |
[Neurologic complications after bone marrow transplantation].
Topics: Adolescent; Adult; Anemia, Aplastic; Bone Marrow Transplantation; Brain; Central Nervous System Diseases; Child; Demyelinating Diseases; Electroencephalography; Evoked Potentials, Visual; Female; Humans; Leukemia; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate; Middle Aged; Neurologic Examination; Postoperative Complications; Radiation Injuries; Spinal Cord; Tomography, X-Ray Computed; Whole-Body Irradiation | 1991 |
Central nervous system involvement in the erythrophagocytic disorders of infancy: the role of cerebrospinal fluid neopterins in their differential diagnosis and clinical management.
Topics: Biopterins; Central Nervous System Diseases; Diagnosis, Differential; Drug Therapy, Combination; Etoposide; Histiocytosis, Non-Langerhans-Cell; Humans; Infant; Infant, Newborn; Macrophage Activation; Methotrexate; Neopterin; Prednisolone; Virus Diseases | 1990 |
Central nervous system involvement in non-Hodgkin's lymphomas.
Topics: Adult; Antineoplastic Agents; Central Nervous System Diseases; Cytophotometry; DNA, Neoplasm; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Protein Binding; Vitamin B 12 | 1989 |
Rheumatology.
Topics: Arthritis, Rheumatoid; Central Nervous System Diseases; Gout; Humans; Methotrexate; Rheumatology; Sjogren's Syndrome | 1989 |
Methotrexate in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow; Carcinogens; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Drug Eruptions; Gastrointestinal Diseases; Humans; Immunosuppressive Agents; Lung Diseases; Methotrexate; Stomatitis; Teratogens | 1988 |
Leukemia in the central nervous system.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Humans; Injections, Spinal; Leukemia, Lymphoid; Methotrexate; Middle Aged | 1988 |
[Meningeal involvement in ALL. Comparative study of 2 methods of protecting the CNS].
Topics: Central Nervous System Diseases; Child, Preschool; Combined Modality Therapy; Female; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
Twelve years experience with methotrexate infusions in childhood ALL.
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Humans; Infant; Infusions, Intravenous; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
Beta 2-microglobulin, lysozyme and lactoferrin in cerebrospinal fluid in patients with lymphoma or leukaemia: relationship to CNS involvement and the effect of prophylactic intrathecal treatment with methotrexate.
Topics: Adolescent; Adult; Aged; beta 2-Microglobulin; Central Nervous System Diseases; Female; Humans; Injections, Spinal; Lactoferrin; Lactoglobulins; Leukemia; Lymphoma; Male; Methotrexate; Middle Aged; Muramidase; Time Factors | 1987 |
Cerebrospinal fluid protein findings during prophylaxis and treatment of neuromeningosis in leukaemic patients.
Topics: Adult; Aged; Albumins; Central Nervous System Diseases; Cerebrospinal Fluid Proteins; Cytarabine; Female; Humans; Immunoglobulin A; Immunoglobulin G; Injections, Spinal; Leukemia; Male; Meningeal Neoplasms; Methotrexate; Middle Aged | 1987 |
The intraventricular reservoir in the treatment of neurological disease secondary to hematological malignancy: an eight year experience.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Central Nervous System Diseases; Female; Humans; Injections, Spinal; Leukemia; Lymphoma, Non-Hodgkin; Male; Meningitis; Methotrexate; Middle Aged | 1986 |
[The treatment and neurological complications in the children with acute lymphoblastic leukemia].
Topics: Central Nervous System Diseases; Child; Electroencephalography; Evoked Potentials, Visual; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prospective Studies; Risk Factors | 1987 |
T lymphocyte line-mediated experimental allergic encephalomyelitis--a pharmacologic model for testing of immunosuppressive agents for the treatment of autoimmune central nervous system disease.
Topics: Animals; Autoimmune Diseases; Cell Line; Central Nervous System Diseases; Disease Models, Animal; Drug Tolerance; Encephalomyelitis; Female; Immunosuppressive Agents; Injections, Intraperitoneal; Injections, Intravenous; Methotrexate; Rats; Rats, Inbred Lew; T-Lymphocytes | 1987 |
Cerebrospinal fluid beta-2-microglobulin: a reliable index of leukaemic infiltration of central nervous system.
Topics: Acute Disease; Adolescent; Adult; Aged; beta 2-Microglobulin; Central Nervous System Diseases; Child; Cytarabine; Female; Follow-Up Studies; Humans; Injections, Spinal; Leukemia; Male; Methotrexate; Middle Aged | 1986 |
[Reduced central nervous system leukemia by prophylaxis with intermittent intrathecal methotrexate and prednisolone in adults with acute leukemia].
Topics: Acute Disease; Adolescent; Adult; Aged; Central Nervous System Diseases; Female; Humans; Injections, Spinal; Leukemia; Male; Methotrexate; Middle Aged; Prednisolone; Time Factors | 1985 |
Central nervous system morbidity following an initial isolated central nervous system relapse and its subsequent therapy in childhood acute lymphoblastic leukemia.
Topics: Acute Disease; Central Nervous System Diseases; Child; Combined Modality Therapy; Humans; Intelligence Tests; Leukemia, Lymphoid; Male; Methotrexate; Nervous System Neoplasms; Radiography; Recurrence | 1985 |
CSF in CNS leukaemia.
Topics: Central Nervous System Diseases; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged | 1985 |
Central nervous system and testicular involvement in acute lymphoblastic leukaemia.
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Testicular Neoplasms | 1985 |
Neurologic complications of bone marrow transplantation.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Brain Diseases, Metabolic; Central Nervous System; Central Nervous System Diseases; Cerebrovascular Disorders; Child; Child, Preschool; Female; Graft vs Host Disease; Humans; Infections; Leukemia; Male; Methotrexate; Middle Aged; Necrosis; Neoplasms; Postoperative Complications; Seizures; Spinal Cord Diseases | 1985 |
Acute lymphoblastic leukaemia in adults in the northern region of England--a study of 75 cases.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Central Nervous System Diseases; Combined Modality Therapy; England; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Prospective Studies; Time Factors; Vincristine | 1985 |
[Therapy of leukemic and sarcomatous meningopathies in the adult age].
Topics: Adult; Central Nervous System Diseases; Chemical Phenomena; Chemistry; Humans; Injections, Spinal; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Meninges; Methotrexate; Neoplasms | 1972 |
Reservoirs for intraventricular chemotherapy.
Topics: Age Factors; Antineoplastic Agents; Catheterization; Central Nervous System Diseases; Cerebral Ventricles; Child; Child, Preschool; Humans; Injections; Injections, Spinal; Leukemia, Lymphoid; Methods; Methotrexate; Neurologic Manifestations | 1973 |
Letter: Leukaemia of the central nervous system.
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Child, Preschool; Humans; Infant; Injections, Spinal; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Meninges; Methotrexate | 1974 |
Cytocentrifugation in the management of central nervous system leukemia.
Topics: Arachnoiditis; Central Nervous System Diseases; Centrifugation; Cytarabine; Humans; Hydrocortisone; Injections, Spinal; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms, Nerve Tissue | 1972 |
Childhood acute lymphoblastic leukemia. a survey of children treated between 1963 and 1972 at Children's Memorial Hospital, Chicago.
Topics: Adolescent; Bacterial Infections; Central Nervous System Diseases; Chicago; Child; Child, Preschool; Cyclophosphamide; Female; Follow-Up Studies; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1974 |
[Treatment of leukemic manifestations in the central nervous system].
Topics: Central Nervous System Diseases; Humans; Leukemia; Methotrexate | 1974 |
Recovery of meningeal leukaemia. A case report.
Topics: Adult; Central Nervous System Diseases; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Prednisone | 1972 |
Central nervous system involvement in acute childhood leukemia.
Topics: Adolescent; Central Nervous System Diseases; Cerebrospinal Fluid; Child; Child, Preschool; Cytodiagnosis; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Methotrexate; Spinal Puncture | 1972 |
Treatment of acute lymphoblastic leukaemia.
Topics: Asparaginase; Central Nervous System Diseases; Child; Daunorubicin; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1972 |
Retrospective study and perspectives in the treatment of meningeal leukaemia.
Topics: Adolescent; Adult; Brain Diseases; Central Nervous System Diseases; Cerebrospinal Fluid; Cobalt Isotopes; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1972 |
Irradiation of C.N.S. in leukaemia.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Methotrexate; Radiotherapy Dosage; Remission, Spontaneous; Spine | 1973 |
Editorial: Treatment of childhood leukemia.
Topics: Acute Disease; Age Factors; Central Nervous System; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Humans; Injections, Spinal; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Radiation Effects; Remission, Spontaneous; Time Factors; Vincristine | 1973 |
Factors that influence the appearance of central nervous system leukemia.
Topics: Central Nervous System Diseases; Cerebrospinal Fluid; Cobalt Radioisotopes; Daunorubicin; Humans; Injections, Spinal; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Mercaptopurine; Methotrexate; Prednisone; Radioisotope Teletherapy; Recurrence; Retrospective Studies; Vincristine | 1973 |
Combination therapy in 130 patients with acute lymphoblastic leukemia (protocol 06 LA 66-Paris).
Topics: Adolescent; Adult; Age Factors; Aged; Central Nervous System Diseases; Child; Child, Preschool; Daunorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Heart; Heart Diseases; Humans; Infant; Leukemia, Lymphoid; Male; Meninges; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Prognosis; Remission, Spontaneous; Sex Factors; Time Factors; Vincristine | 1973 |
Rationale and results of combination chemotherapy and central nervous system irradiation in acute lymphocytic leukemia.
Topics: Adolescent; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Cobalt Radioisotopes; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Radiation Effects | 1973 |
Letter: "Aseptic meningoencephalopathy" or "neurotoxicity" in leukemia?
Topics: Central Nervous System Diseases; Child; Humans; Leukemia, Lymphoid; Methotrexate | 1974 |
[Leukemic infiltrates into the central nervous system. Early symptoms, clinical aspects and indications for prophylactic treatment].
Topics: Acute Disease; Adolescent; Age Factors; Brain Diseases; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Intracranial Pressure; Leukemia, Lymphoid; Male; Meninges; Methotrexate | 1974 |
Cytology of the cerebrospinal fluid in children with acute lymphoblastic leukemia.
Topics: Acute Disease; Cell Count; Central Nervous System Diseases; Cerebrospinal Fluid; Child; Cytarabine; Female; Humans; Leukemia, Lymphoid; Methotrexate; Remission, Spontaneous | 1974 |
Morphological criteria for prognostication of acute lymphoblastic leukaemia.
Topics: Bone Marrow Cells; Central Nervous System Diseases; Child; Child, Preschool; Female; Hepatomegaly; Humans; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Male; Methotrexate; Prognosis; Remission, Spontaneous; Splenomegaly | 1974 |
[Treatment of acute lymphoblastic leukemia. Evaluation of 6-year-cooperative studies in Argentina (author's transl)].
Topics: Adult; Central Nervous System Diseases; Child; Daunorubicin; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1974 |
Cerebral calcification in childhood leukemia mimicking Sturge-Weber syndrome. Report of two cases.
Topics: Angiomatosis; Biopsy; Brain; Calcinosis; Central Nervous System Diseases; Cerebral Angiography; Child; Child, Preschool; Cobalt Radioisotopes; Diagnosis, Differential; Female; Humans; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Radioisotope Teletherapy; Remission, Spontaneous; Sturge-Weber Syndrome; Tomography, X-Ray; Vincristine | 1974 |
[Central nervous system complications in acute leukemia].
Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Methotrexate | 1974 |
Prophylactic treatment of meningeal leukemia in children by intrathecal methotrexate.
Topics: Bone Marrow Examination; Brain Diseases; Central Nervous System Diseases; Cerebrospinal Fluid; Child; Child, Preschool; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Meninges; Mercaptopurine; Methotrexate; Remission, Spontaneous; Vincristine | 1972 |
Proceedings: Prognosis in central nervous system leukemia.
Topics: Blood Cell Count; Blood Platelets; Central Nervous System Diseases; Child; Drug Therapy, Combination; Humans; Leukemia; Leukocytosis; Lymphoma; Meninges; Methotrexate; Prognosis; Radiotherapy Dosage; Skull | 1972 |
[Attempt at the prevention of lymphosarcoma penetration into the central nervous system].
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Female; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Metastasis; Neoplasms | 1973 |
Editorial: Preventive central-nervous-system therapy in acute leukemia.
Topics: Acute Disease; Arachnoid; Arachnoiditis; Brain Diseases; Central Nervous System; Central Nervous System Diseases; Child; Humans; Injections, Spinal; Leukemia; Meningitis; Methotrexate; Radiotherapy; Radiotherapy Dosage; Remission, Spontaneous | 1973 |
Clinical experience with L-asparaginase.
Topics: Adolescent; Adult; Aged; Asparaginase; Azaserine; Burkitt Lymphoma; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Escherichia coli; Female; Humans; Leukemia, Lymphoid; Leukopenia; Lymphoma, Non-Hodgkin; Lymphopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasms; Pancreatitis; Thrombocytopenia | 1970 |
Low-dose radiation therapy for leukemic involvement of the central nervous system.
Topics: Brain; Central Nervous System; Central Nervous System Diseases; Child; Humans; Injections, Spinal; Leukemia; Methotrexate; Prognosis; Radiotherapy Dosage; Remission, Spontaneous; Spinal Cord; Time Factors | 1972 |
Management of CNS leukemia in childhood. An outline of current concepts.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Humans; Leukemia; Meninges; Methotrexate; Pyrimethamine | 1972 |
[Central nervous system infiltration in acute leukemias in children].
Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate | 1967 |
[Clinical course of leukemias with symptoms of the central nervous system in relation to treatment].
Topics: Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Injections, Spinal; Leukemia, Lymphoid; Male; Methotrexate | 1967 |
A study of "total therapy" of acute lymphocytic leukemia in children.
Topics: Adolescent; Antineoplastic Agents; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1968 |
CNS leukemia mimicking multifocal leukoencephalopathy.
Topics: Brain Diseases; Central Nervous System Diseases; Child, Preschool; Diagnosis, Differential; Humans; Leukemia, Lymphoid; Male; Methotrexate; Spinal Puncture | 1970 |
Studies on the use of "prophylactic" intrathecal amethopterin in childhood leukemia.
Topics: Central Nervous System Diseases; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Leukocytes; Male; Mercaptopurine; Methotrexate; Prednisone; Spinal Puncture; Vincristine | 1970 |
[Ocular symptomatology associated with acute leukemia].
Topics: Adrenal Cortex Hormones; Central Nervous System Diseases; Eye Diseases; Facial Nerve; Humans; Leukemia, Lymphoid; Methotrexate; Oculomotor Nerve; Optic Nerve; Papilledema; Retinal Detachment; Retinal Hemorrhage; Retinitis; Trochlear Nerve; Uveitis | 1968 |
Treatment of acute leukemia with L-asparaginase--preliminary results on 84 cases.
Topics: Acute Disease; Asparaginase; Asparagine; Blood Coagulation Disorders; Cells, Cultured; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Daunorubicin; Humans; Kidney Diseases; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Liver Function Tests; Methotrexate; Prednisone; Valine; Vincristine | 1970 |
Comparison of CNS-leukaemia in children with acute leukaemia, induced either with rubidomycin or L-asparaginase.
Topics: Asparaginase; Central Nervous System Diseases; Child; Child, Preschool; Daunorubicin; Drug Therapy, Combination; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Neoplasm Metastasis; Prednisolone; Remission, Spontaneous; Vincristine | 1971 |
The use of combination therapy in leukemia remission.
Topics: Adolescent; Antineoplastic Agents; Central Nervous System Diseases; Child; Dactinomycin; Humans; Leukemia; Mechlorethamine; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1969 |
[Induction and interval treatment of leukemias in children and juveniles].
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Injections, Intravenous; Leukemia; Male; Meninges; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1969 |
Central nervous system involvement in Burkitt's lymphoma.
Topics: Brain Neoplasms; Burkitt Lymphoma; Central Nervous System Diseases; Cerebrospinal Fluid; Cognition Disorders; Cyclophosphamide; Cytarabine; Folic Acid; Humans; Injections, Spinal; Lymphocytosis; Methotrexate; Neoplasm Metastasis; Paraplegia; Vincristine | 1970 |
[Complications in the central nervous system in acute leukemia in children. Clinical contribution].
Topics: Central Nervous System Diseases; Humans; Leukemia; Methotrexate; Neurologic Manifestations; Obesity | 1969 |
Clinical investigations in the treatment of meningeal leukemia: radiation therapy regimens vs. conventional intrathecal methotrexate.
Topics: Adolescent; Blood Cell Count; Bone Marrow Examination; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Injections, Spinal; Leukemia; Leukopenia; Male; Methotrexate; Radiotherapy | 1969 |