Page last updated: 2024-08-25

methotrexate and Cardiovascular Stroke

methotrexate has been researched along with Cardiovascular Stroke in 31 studies

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.45)18.7374
1990's2 (6.45)18.2507
2000's5 (16.13)29.6817
2010's16 (51.61)24.3611
2020's6 (19.35)2.80

Authors

AuthorsStudies
Bolster, MB; Choi, HK; Lu, N; Smith, ID; Wei, J; Zhang, Y1
Ahmed, S; Carsons, SE; De Leon, J; Kasselman, L; Reiss, AB; Teboul, I1
D'Andrea, E; Desai, RJ; Glynn, RJ; He, M; Kim, SC; Lee, H; Weinblatt, ME1
Cornel, JH; Hoogeveen, RM; Stroes, ESG1
Ayhan, A; Benkhoff, M; Dannenberg, L; Helten, C; Huhn-Wientgen, R; Ignatov, D; Kelm, M; Levkau, B; M'Pembele, R; Mourikis, P; Petzold, T; Polzin, A; Sarabhai, T; Trojovsky, K; Zako, S; Zeus, T1
Chen, J; Cooper, D; Norling, LV1
de Lima, AD; Guido, MC; Kalil-Filho, R; Maranhão, RC; Marques, AF; Nicolau, JC; Salemi, VM; Tavares de Melo, MD; Tavares, ER1
Couzin-Frankel, J1
Bertrand, O; Butman, S; Clearfield, M; Everett, BM; Glynn, RJ; Goldhaber, SZ; Gupta, M; Hasan, A; Iturriaga, E; Johnston, J; Le May, M; Libby, P; MacFadyen, JG; Mam, V; Ofori, C; Paynter, NP; Pradhan, A; Ridker, PM; Rosenberg, Y; Saklayen, M; Seagle, R; Singh, N; Solomon, DH; Tsigoulis, M; Verma, S; Zaharris, E1
Ridker, PM1
Goyal, M; Pandey, A1
Flores, RM; Kanth, R; Shah, MS1
Chen, L; Curtis, JR; Graham, DJ; Griffin, MR; Harrold, LR; Herrinton, LJ; Kowal, MK; Kuriya, B; Lewis, JD; Lii, J; Liu, L; Rassen, JA; Saag, KG; Solomon, DH1
Clearfield, M; Everett, BM; Glynn, RJ; Gupta, M; Hasan, AA; Libby, P; Macfadyen, J; Paynter, N; Pradhan, AD; Ridker, PM; Solomon, DH; Zaharris, E1
da Silva, RL; Fattah, T; Lueneberg, ME; Mascia Gottschall, CA; Moreira, DM1
Ahlehoff, O; Bryld, LE; Gislason, G; Gniadecki, R; Hansen, PR; Iversen, L; Kristensen, SL; Lasthein, S; Lindhardsen, J; Skov, L; Torp-Pedersen, C1
Al-Mutairi, N; Bachelez, H; Gulliver, S; Gulliver, WP; Randell, S; Young, HM1
Deleuran, MS; Hjuler, KF; Iversen, L; Jakobsen, L; Olsen, M; Riis, JL; Vestergaard, C1
Al-Mutairi, N; Shaaban, D1
Cloutier, M; Dea, K; Guérin, A; Mulani, P; Sundaram, M; Wu, JJ1
Hobbs, R; Tan, CD; Zardkoohi, O1
Ahlehoff, O; Gislason, G; Hansen, PR; Lindhardsen, J; Skov, L1
ACQUARELLI, MJ; FEDER, RJ; GORDON, HE1
Asakura, M; Asanuma, H; Hori, M; Kitakaze, M; Minamino, T; Mori, H; Node, K; Ogai, A; Ogita, H; Sanada, S; Shinozaki, Y; Takashima, S; Tomoike, H1
Krishnan, E; Lingala, VB; Singh, G1
Choudhry, VP; Dixit, A; Kannan, M; Mahapatra, M; Saxena, R1
Bernatsky, S; Hudson, M; Suissa, S1
Huikuri, HV; Kettunen, R; Oikarinen, A; Takkunen, JT1
Neuhaus, KL; Zeymer, U1
Sahn, SA1

Reviews

2 review(s) available for methotrexate and Cardiovascular Stroke

ArticleYear
Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation.
    Cells, 2021, 04-13, Volume: 10, Issue:4

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Atherosclerosis; Etanercept; Heart Failure; Humans; Hydroxychloroquine; Inflammation; Methotrexate; Myocardial Infarction; Myocardial Ischemia; Risk Factors; Stroke Volume; Sulfasalazine

2021
Immunologic diseases of the pleura.
    Clinics in chest medicine, 1985, Volume: 6, Issue:1

    Topics: Adult; Aged; Bromocriptine; Cardiac Surgical Procedures; Collagen Diseases; Dantrolene; Female; Granulomatosis with Polyangiitis; Heart Injuries; Humans; Immune System Diseases; Immunoblastic Lymphadenopathy; Lupus Erythematosus, Systemic; Male; Methotrexate; Methysergide; Middle Aged; Myocardial Infarction; Nitrofurantoin; Pacemaker, Artificial; Pleural Diseases; Pleural Effusion; Practolol; Procarbazine; Rheumatic Diseases; Sarcoidosis; Syndrome; Thoracic Injuries

1985

Trials

4 trial(s) available for methotrexate and Cardiovascular Stroke

ArticleYear
Methotrexate effects on adenosine receptor expression in peripheral monocytes of persons with type 2 diabetes and cardiovascular disease.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2022, Volume: 70, Issue:6

    Topics: Adenosine; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 2; Gene Expression; Humans; Inflammation; Leukocytes, Mononuclear; Methotrexate; Monocytes; Myocardial Infarction; Receptors, Purinergic P1

2022
Low-Dose Methotrexate for the Prevention of Atherosclerotic Events.
    The New England journal of medicine, 2019, 02-21, Volume: 380, Issue:8

    Topics: Aged; Atherosclerosis; C-Reactive Protein; Cardiovascular Diseases; Confidence Intervals; Coronary Artery Disease; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Interleukin-1beta; Interleukin-6; Male; Metabolic Syndrome; Methotrexate; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Statistics, Nonparametric; Stroke; Transaminases

2019
Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis.
    American heart journal, 2013, Volume: 166, Issue:2

    Topics: Algorithms; Anti-Inflammatory Agents; Atherosclerosis; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Inflammation; Metabolic Syndrome; Methotrexate; Myocardial Infarction; Research Design

2013
Rationale and design of the TETHYS trial: the effects of methotrexate therapy on myocardial infarction with ST-segment elevation.
    Cardiology, 2013, Volume: 126, Issue:3

    Topics: Adult; Aged; Area Under Curve; Blood Sedimentation; C-Reactive Protein; Cardiovascular Agents; Creatine Kinase; Creatine Kinase, MB Form; Double-Blind Method; Humans; Methotrexate; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Statistics as Topic; Treatment Outcome; Troponin; Young Adult

2013

Other Studies

25 other study(ies) available for methotrexate and Cardiovascular Stroke

ArticleYear
Alcohol consumption and the risk of mortality and myocardial infarction in patients with rheumatoid arthritis.
    Clinical and experimental rheumatology, 2022, Volume: 40, Issue:9

    Topics: Alcohol Drinking; Arthritis, Rheumatoid; Cohort Studies; Humans; Methotrexate; Myocardial Infarction; Risk Factors

2022
Cardiovascular Risks of Hydroxychloroquine vs Methotrexate in Patients With Rheumatoid Arthritis.
    Journal of the American College of Cardiology, 2022, 07-05, Volume: 80, Issue:1

    Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Hydroxychloroquine; Medicare; Methotrexate; Myocardial Infarction; Risk Factors; United States

2022
[Anti-inflammatory therapy in cardiovascular disease; from hypothesis to future guideline?]
    Nederlands tijdschrift voor geneeskunde, 2020, 10-22, Volume: 164

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Cardiovascular Diseases; Colchicine; Humans; Inflammation; Methotrexate; Myocardial Infarction; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Translational Research, Biomedical

2020
MTX Treatment Does Not Improve Outcome in Mice with AMI.
    Pharmacology, 2021, Volume: 106, Issue:3-4

    Topics: Animals; Blood Cell Count; Blood Platelets; Disease Models, Animal; Male; Methotrexate; Mice, Inbred C57BL; Myocardial Infarction; Serum Amyloid P-Component; Systole; Treatment Outcome; Ventricular Function, Left

2021
Methotrexate carried in lipid core nanoparticles reduces myocardial infarction size and improves cardiac function in rats.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Animals; Apoptosis; Coronary Vessels; Lipids; Male; Methotrexate; Myocardial Infarction; Myocardium; Nanoparticles; Necrosis; Rats, Wistar; Vascular Endothelial Growth Factor A; Ventricular Function, Left; Ventricular Remodeling

2017
Anti-inflammatory prevents heart attacks.
    Science (New York, N.Y.), 2017, Sep-01, Volume: 357, Issue:6354

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Clinical Trials as Topic; Humans; Infusions, Intravenous; Interleukin-1beta; Methotrexate; Myocardial Infarction

2017
Methotrexate for Prevention of Cardiovascular Events. Reply.
    The New England journal of medicine, 2019, 06-06, Volume: 380, Issue:23

    Topics: Cardiovascular Diseases; Humans; Methotrexate; Myocardial Infarction

2019
Methotrexate: CIRTified for preventing atherosclerotic events?
    The journal of the Royal College of Physicians of Edinburgh, 2019, Volume: 49, Issue:2

    Topics: Antirheumatic Agents; Atherosclerosis; Hospitalization; Humans; Methotrexate; Myocardial Infarction; Stroke

2019
Statin-associated polymyositis following omeprazole treatment.
    Clinical medicine & research, 2013, Volume: 11, Issue:2

    Topics: Anticholesteremic Agents; Atorvastatin; Drug Interactions; Esophagitis; Gemfibrozil; Heptanoic Acids; Humans; Male; Methotrexate; Middle Aged; Myocardial Infarction; Omeprazole; Polymyositis; Prednisone; Proton Pump Inhibitors; Pyrroles; Treatment Outcome; Withholding Treatment

2013
Cardiovascular risk in rheumatoid arthritis: comparing TNF-α blockade with nonbiologic DMARDs.
    The American journal of medicine, 2013, Volume: 126, Issue:8

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Cohort Studies; Female; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Proportional Hazards Models; Retrospective Studies; Risk; Stroke; Treatment Outcome; Tumor Necrosis Factor-alpha

2013
Cardiovascular outcomes and systemic anti-inflammatory drugs in patients with severe psoriasis: 5-year follow-up of a Danish nationwide cohort.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2015, Volume: 29, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents; Biological Products; Cardiovascular Diseases; Cause of Death; Climatotherapy; Cyclosporine; Denmark; Dermatologic Agents; Female; Follow-Up Studies; Humans; Incidence; Longitudinal Studies; Male; Methotrexate; Middle Aged; Myocardial Infarction; Phototherapy; Psoriasis; Registries; Retinoids; Severity of Illness Index; Stroke; Tumor Necrosis Factor-alpha; Ustekinumab

2015
Psoriasis Patients Treated With Biologics and Methotrexate Have a Reduced Rate of Myocardial Infarction: A Collaborative Analysis Using International Cohorts.
    Journal of cutaneous medicine and surgery, 2016, Volume: 20, Issue:6

    Topics: Administration, Cutaneous; Administration, Oral; Biological Products; Canada; Cohort Studies; Comorbidity; Denmark; Dermatologic Agents; Humans; Incidence; Internationality; Kuwait; Methotrexate; Myocardial Infarction; Protective Factors; Psoriasis; Severity of Illness Index; Ultraviolet Therapy; United States

2016
Hospital-diagnosed atopic dermatitis and long-term risk of myocardial infarction: a population-based follow-up study.
    BMJ open, 2016, 11-11, Volume: 6, Issue:11

    Topics: Adult; Aged; Ambulatory Care; Azathioprine; Case-Control Studies; Cyclosporine; Denmark; Dermatitis, Atopic; Eczema; Female; Follow-Up Studies; Hospitalization; Hospitals; Humans; Immunosuppressive Agents; Incidence; Male; Methotrexate; Middle Aged; Myocardial Infarction; Registries; Risk Factors; Young Adult

2016
The effect of tumor necrosis factor inhibitor therapy on the incidence of myocardial infarction in patients with psoriasis: a retrospective study.
    The Journal of dermatological treatment, 2018, Volume: 29, Issue:1

    Topics: Adalimumab; Administration, Topical; Adult; Dermatologic Agents; Drug Therapy, Combination; Etanercept; Female; Humans; Incidence; Infliximab; Male; Methotrexate; Middle Aged; Myocardial Infarction; Psoriasis; Retrospective Studies; Risk; Tumor Necrosis Factor-alpha

2018
Cardiovascular event risk assessment in psoriasis patients treated with tumor necrosis factor-α inhibitors versus methotrexate.
    Journal of the American Academy of Dermatology, 2017, Volume: 76, Issue:1

    Topics: Adalimumab; Adolescent; Adult; Aged; Angina, Unstable; Cardiovascular Diseases; Dermatologic Agents; Etanercept; Female; Humans; Infliximab; Ischemic Attack, Transient; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Protective Factors; Psoriasis; Risk Assessment; Stroke; Time Factors; Tumor Necrosis Factor-alpha; Young Adult

2017
A rare shock.
    The American journal of medicine, 2011, Volume: 124, Issue:11

    Topics: Aged; Anti-Inflammatory Agents; Biopsy; Cardiac Catheterization; Churg-Strauss Syndrome; Coronary Angiography; Coronary Care Units; Diagnosis, Differential; Diuretics; Drug Therapy, Combination; Echocardiography; Electrocardiography; Endocardium; Eosinophilia; Female; Furosemide; Hemodynamics; Humans; Immunosuppressive Agents; Infusions, Intravenous; Methotrexate; Methylprednisolone; Myocardial Infarction; Myocardium; Nitroprusside; Prednisone; Shock, Cardiogenic; Vasodilator Agents

2011
[Patients with psoriasis have an increased risk of cardiovascular diseases].
    Ugeskrift for laeger, 2012, May-21, Volume: 174, Issue:21

    Topics: Antirheumatic Agents; Atrial Fibrillation; Cardiovascular Diseases; Denmark; Humans; Immunosuppressive Agents; Methotrexate; Myocardial Infarction; Practice Guidelines as Topic; Psoriasis; Risk Factors; Venous Thromboembolism

2012
COMPLICATIONS INHERENT IN CONTINUOUS INTRA-ARTERIAL CHEMOTHERAPY OF HEAD AND NECK CARCINOMA.
    Cancer, 1964, Volume: 17

    Topics: Carcinoma, Squamous Cell; Cerebrovascular Disorders; Embolism, Air; Head; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Myocardial Infarction; Neoplasms; Pneumonia; Pulmonary Atelectasis; Pulmonary Embolism; Sepsis; Squamous Cell Carcinoma of Head and Neck; Thrombophlebitis

1964
Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts.
    Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:4

    Topics: 2-Aminoadipic Acid; Adenosine; Animals; Cardiotonic Agents; Dogs; Methotrexate; Myocardial Infarction; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline

2004
Declines in mortality from acute myocardial infarction in successive incidence and birth cohorts of patients with rheumatoid arthritis.
    Circulation, 2004, Sep-28, Volume: 110, Issue:13

    Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Case Management; Cohort Studies; Female; Humans; Immunosuppressive Agents; Incidence; Male; Methotrexate; Middle Aged; Mortality; Myocardial Infarction; North America; Outcome Assessment, Health Care; Prednisone; Prospective Studies; Regression Analysis; Risk

2004
Roles of protein C, protein S, and antithrombin III in acute leukemia.
    American journal of hematology, 2006, Volume: 81, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Antithrombin III; Asparaginase; Cyclophosphamide; Cytarabine; Disseminated Intravascular Coagulation; Female; Humans; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Myocardial Infarction; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Protein C; Protein S; Thrombosis; Vincristine

2006
Antirheumatic drug use and the risk of acute myocardial infarction.
    Arthritis and rheumatism, 2006, Aug-15, Volume: 55, Issue:4

    Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Cohort Studies; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Myocardial Infarction; Random Allocation; Treatment Outcome

2006
Heart risks of RA drugs compared. Biologics confer same risk as old-fashioned methotrexate; cytotoxic drugs increase cardiac risk.
    DukeMedicine healthnews, 2007, Volume: 13, Issue:3

    Topics: Arthritis, Rheumatoid; Humans; Immunosuppressive Agents; Methotrexate; Myocardial Infarction; Stroke

2007
Methotrexate-linked ventricular arrhythmias.
    Acta dermato-venereologica, 1995, Volume: 75, Issue:5

    Topics: Administration, Oral; Adult; Angina Pectoris; Arrhythmias, Cardiac; Biopsy; Coronary Angiography; Dermatologic Agents; Electrocardiography, Ambulatory; Endocardium; Heart Arrest; Humans; Male; Methotrexate; Myocardial Infarction; Psoriasis; Recurrence; Ventricular Premature Complexes

1995
[Acute coronary thrombosis and myocardial ischemia following chemotherapy of Hodgkin's disease].
    Onkologie, 1990, Volume: 13, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Coronary Disease; Coronary Thrombosis; Etoposide; Hodgkin Disease; Humans; Ifosfamide; Male; Methotrexate; Myocardial Infarction; Neoplasm Recurrence, Local

1990