Page last updated: 2024-08-25

methotrexate and Carcinoma, Hepatocellular

methotrexate has been researched along with Carcinoma, Hepatocellular in 107 studies

Research

Studies (107)

Timeframe	Studies, this research(%)	All Research%
pre-1990	62 (57.94)	18.7374
1990's	15 (14.02)	18.2507
2000's	14 (13.08)	29.6817
2010's	12 (11.21)	24.3611
2020's	4 (3.74)	2.80

Authors

Authors	Studies
Duch, D; Ferone, R; Galivan, J; Gaumont, Y; Jones, C; Kisliuk, RL; Maley, F; Nair, MG; Patil, SD	1
Hummel-Eisenbeiss, J; Jedlitschky, G; Keppler, D; Nies, AT; Rius, M	1
Jiang, J; Lai, L; Liu, X; Sun, B; Wang, X; Xiong, J; Yao, Y; Zhang, X	1
Chen, M; He, B; Jiang, Y; Li, N; Li, Z; Liu, Q; Ma, J; Wang, W	1
Abdel-Moneim, AM; Alfwuaires, M; Algefare, AI; Elmenshawy, OM; Elsawy, H; Khalil, M; Sedky, A	1
Inoue, J; Iwata, T; Kakazu, E; Masamune, A; Ninomiya, M; Sano, A; Tsuruoka, M	1
Cai, H; Cao, K; Chen, Z; Li, W; Liu, X; Wang, J; Wu, L; Zhao, J	1
Eso, Y; Marusawa, H; Mimori, T; Mishima, M; Morita, M; Sawada, K; Seno, H; Takahashi, K; Takai, A; Ueda, Y; Yoshiji, S	1
Cheng, XL; Li, B; Li, L; Li, MY; Li, ZQ; Lu, W; Zhou, TY	1
Bhat, MK; Kumari, R; Meena, AS; Mohammad, N; Sharma, A; Singh, SV	1
Chen, H; Li, R; Liu, Y; Wang, Y; Wu, J; Yang, X; Zhang, N; Zhou, P	1
Hayashi, S; Miyazawa, M; Nishikawa, T; Oguri, H	1
Chang, WJ; Chen, JN; Chou, PL; Hung, YT; Wei, CW; Yiang, GT; Yu, YL	1
An, T; Liu, Y; Sun, D; Wang, Y; Zhang, C; Zhang, N; Zhou, P	1
Chaudhuri, AS; Fan, Y; Huo, M; Qi, X; Wu, Z; Yuan, S; Zhao, M	1
Hibino, Y; Hirai, M; Isago, T; Kinoshita, A; Kobayashi, D; Komada, F; Saitoh, Y; Uchino, K; Yagi, K	1
Buwalda, B; Konsman, JP; Koolhaas, JM; Pourtau, L; Schagen, SB; Seigers, R; van Dam, FS	1
Gong, R; Meng, X; Xiong, M; Zhong, X	1
Deschatrette, J; Ng-Bonaventure, K; Philippe, L; Wolfrom, C	1
Davis, GL; Keeffe, EB	1
Kuang, A; Liang, Z; Ou, X; Peng, X; Zhong, Y	1
Lim, BG; Ng, KH; Wong, KP	1
ADAMSON, RH; LOO, TL; MORRIS, HP	1
KIRKHAM, JS	1
NIXON, HH	1
MORSE, PA; POTTER, VR	1
GEBERT, R; GENTRY, GA; IVES, DH; MORSE, PA; POTTER, VR	1
ROTHENBERG, SP	1
Danno, M; Dono, K; Hatanaka, T; Hayashi, T; Iijima, S; Kato, T; Kikkawa, N; Kurokawa, E; Monden, M; Nagano, H; Nakamori, S; Naoi, Y; Ohshima, S; Sakon, M; Tsujie, M; Umeshita, K; Yamamoto, H	1
Kuang, AR; Liang, ZL; Ou, XH; Peng, X; Zhong, YG	1
Deschatrette, J; Guerroui, S; Wolfrom, C	1
Goldman, ID; Hanscom, M; Zhao, R	1
Cheng, BB; Gu, W; Han, J; Li, B; Ling, CQ; Zhang, YN	1
Chen, J; Deng, CM; Li, GY; Su, XS; Xiao, XQ	1
Ling, MT; Wang, X; Wong, YC; Zhang, X	1
Bahendeka, S; Katongole-Mbidde, E; Kyalwazi, SK; Mugerwa, J; Olweny, CL; Otim, D	1
Stockert, RJ; Wu, CH; Wu, GY	1
Choi, TK; Lee, NW; Wong, J	1
Galivan, J; Samsonoff, W; Tarentino, A	1
Dannaher, CL; Tamburro, CH; Yam, LT	1
Donehower, RC; Eddy, JL; Ihde, DC; Myers, CE; Tester, WJ	1
Fonseca, LS; Hunter, JT; Rapp, HJ; Shu, S	1
Friedman, MA	1
Adler, GK; Arbiser, JL; Arbiser, ZK; Majzoub, JA; Martinez, C; Rosen, LB	1
Hu, JL; Qi, CQ; Su, J; Zhen, YC	1
Flintoff, WF; Williams, FM	1
Ansari, R; Gonin, R; Loehrer, PJ; McClean, J; Miller, KD; Mortimer, J; Pletcher, W; Spiridonidis, CH; Weber, G	1
Galle, PR; Heinemann, EM; Hofmann, WJ; Hug, H; Krammer, PH; Müller, M; Strand, S; Stremmel, W; Walczak, H	1
Dono, K; Eguchi, H; Kishimoto, S; Kondo, M; Miyamoto, A; Monden, M; Nagano, H; Nakamori, S; Nakamura, H; Sakon, M; Shimizu, J; Takeda, Y; Umeshita, K; Wakasa, K	1
Chan, JY; Chu, AC; Fung, KP	1
Malicka-Błaszkiewicz, M; Otrocka, M; Verschueren, H	1
Poirier, LA	1
Borsos, T; Ohanian, SH; Segerling, M	3
Oberfield, RA	2
Rosenberg, SA	1
Bernard, J; Chelloul, N; Delbrück, H; Schaison, G	1
Drobník, J; Koutecký, J; Tríska, J; Wichterle, O	1
Falkson, G	1
Andreeva, NA; Ershova, IuA; Nemeriuk, MP; Riabokon', NA; Sokolova, AS	1
Bast, RC; Borsos, T; Greene, SL; Ohanian, SH; Rapp, HJ; Segerling, M; Zbar, B	1
Scheuer, PJ	1
Jackson, RC; Weber, G	1
Roth, JJ; Roth, JS	1
Marz, R; Plagemann, PG; Wohlhueter, RM	1
Brinkley, DM; Cochrane, AM; Murray-Lyon, IM; Williams, R	1
Mosijczuk, AD; Ruymann, FB; Sayers, RJ	1
Habs, G; Habs, M; Schmähl, D	1
Cady, B; Oberfield, RA; Wellwood, JM	1
Zimmerman, HJ	1
Bader, H; Beardsley, GP; DeYarman, MT; Freisheim, JH; Galivan, J; Kerwar, SS; Moroson, BA; O'Connor, BM; Rosowsky, A; Russello, O	1
Desai, DC; Desouza, LJ; Dhir, V; Dinshaw, KA; Jagannath, P; Mohandas, KM; Nagral, A; Sharma, V; Swaroop, VS	1
Caen, J; Cochand-Priollet, B; Lavergne, A; Marteau, P; Mehdi, A; Molho-Sabatier, P; Rambaud, JC	1
Barbosa, JL; Kamen, BA; Kato, GJ; Weitman, SD	1
Dai, Y	1
Bunni, M; Freisheim, JH; Galivan, J; Priest, DG; Rhee, M; Whiteley, JM	1
Abraham, A; Galivan, J; Gaumont, Y; Kisliuk, RL; Nair, MG	1
Ng, TB; Tsao, SW; Yeung, HW	1
Babich, H; Borenfreund, E; Martin-Alguacil, N	1
Fried, M; Ilardi, CF; Kalra, J; Sawitsky, A	1
Eddy, JL; Ihde, DC; Makuch, RW; Matthews, MJ; McIntire, KR; Seeff, LB	1
Adler, M; Cremer, M; Henry, JP; Lecocq, E; Quiriny, M; Ros, P	1
Glimelius, B	1
Buffe, D; Burtin, P; Mawas, C; Schweisguth, O	1
McIntire, KR; Patel, IR; Princler, GL; Vogel, CL	1
Chavez, CM; Conn, JH; Fain, WR	1
Bessot, M; Duprez, A; Kissel, P	1
Hahn, RG; Moertel, CG; Reitemeier, RJ	1
Falkson, G; Geddes, EW	2
Adamson, RH; Henderson, ES; Oliverio, VT	1
Gorgun, B; Watne, AL	1
Potter, VR; Sneider, TW	1
Handschumacher, RE	1
Bukin, IuV; Raushenbakh, MO; Sergeev, AV	1
Keeling, JW	1
Gauldie, J; Hiebert, M; Hillcoat, BL; Marshall, L	1
Maley, F; Maley, GF	1
Bowman, RL; Braslow, NM	1
Adamson, RH; DeVita, VT; Johns, DG; Kyalwazi, SK; Vogel, CL	1
Bhana, D; Dhru, D; Harrison, NW; Kyalwazi, SK; Primack, A	1
Sneider, TW	1
McHenry, CS; Perriard, ER; Santi, DV	1
Morgenthaler, FR; Pettavel, J	1

Reviews

6 review(s) available for methotrexate and Carcinoma, Hepatocellular

Article	Year
Hepatic intraarterial chemotherapy--current status and future prospects--"If you have a short sword, take a step forward". Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:5 Topics: Carcinoma, Hepatocellular; Catheterization; Colonic Neoplasms; Doxorubicin; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Methotrexate; Rectal Neoplasms	1983
Therapeutic approaches to hepatoma. Cancer treatment reviews, 1975, Volume: 2, Issue:1 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Catheterization; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; South Africa	1975
Long-term effects on the liver. Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9 Topics: Anabolic Agents; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; Contraceptives, Oral, Hormonal; Humans; Lipofuscin; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Methotrexate; Oxyphenisatin Acetate; Phenacetin	1975
Drug-induced chronic hepatic disease. The Medical clinics of North America, 1979, Volume: 63, Issue:3 Topics: Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Chronic Disease; Fatty Liver; Hemangioendothelioma; Hexestrol; Humans; Hypertension, Portal; Liver; Liver Cirrhosis; Liver Neoplasms; Methotrexate; Necrosis; Oxyphenisatin Acetate	1979
[Drug-induced hepatic lesions]. Revue medicale de Bruxelles, 1986, Volume: 7, Issue:2 Topics: Adenoma; Amiodarone; Amphetamines; Antineoplastic Agents; Budd-Chiari Syndrome; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Contraceptive Agents; Drug-Related Side Effects and Adverse Reactions; Female; Hemangiosarcoma; Humans; Liver Cirrhosis; Liver Neoplasms; Methotrexate	1986
Systemic cytostatic drug therapy in liver cancer. Annales chirurgiae et gynaecologiae. Supplementum, 1986, Volume: 200 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; Colonic Neoplasms; Doxorubicin; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Methotrexate; Rectal Neoplasms; Semustine; Vincristine	1986

Trials

6 trial(s) available for methotrexate and Carcinoma, Hepatocellular

Article	Year
Chemotherapy for advanced hepatocellular carcinoma. Adriamycin versus quadruple chemotherapy. Cancer, 1984, Feb-01, Volume: 53, Issue:3 Topics: Adult; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Hepatitis B Surface Antigens; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Prospective Studies; Random Allocation; Vincristine	1984
A phase II study of weekly oral methotrexate and zidovudine (AZT) in advanced adenocarcinoma of the pancreas and hepatocellular carcinoma. Investigational new drugs, 1996, Volume: 14, Issue:2 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Pancreatic Neoplasms; Remission Induction; Zidovudine	1996
Quadruple chemotherapy versus radiotherapy in treatment of primary hepatocellular carcinoma. Cancer, 1977, Volume: 40, Issue:2 Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Aspartate Aminotransferases; Bilirubin; Carcinoma, Hepatocellular; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Prognosis; Vincristine	1977
Combination chemotherapy and radiation for palliation of hepatocellular carcinoma. American journal of clinical oncology, 1992, Volume: 15, Issue:4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Drug Evaluation; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Palliative Care; Prospective Studies; Remission Induction; Survival Analysis	1992
Systemic cytostatic drug therapy in liver cancer. Annales chirurgiae et gynaecologiae. Supplementum, 1986, Volume: 200 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Clinical Trials as Topic; Colonic Neoplasms; Doxorubicin; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Methotrexate; Rectal Neoplasms; Semustine; Vincristine	1986
Infusion of liver tumours. British medical journal, 1968, Nov-16, Volume: 4, Issue:5628 Topics: Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Humans; Liver Neoplasms; Methotrexate	1968

Other Studies

96 other study(ies) available for methotrexate and Carcinoma, Hepatocellular

Article	Year
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Breast Neoplasms; Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry; Fibroblasts; Folic Acid; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Liver Neoplasms; Lymphoma; Molecular Structure; Streptococcus; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured	1989
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology (Baltimore, Md.), 2003, Volume: 38, Issue:2 Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Antibodies; Carcinoma, Hepatocellular; Cell Polarity; Cholagogues and Choleretics; Cricetinae; Fibroblasts; Gene Expression; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Male; Mice; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Rats; Taurocholic Acid; Transfection; Transport Vesicles; Tritium	2003
Identification of copper metabolism and cuproptosis-related subtypes for predicting prognosis tumor microenvironment and drug candidates in hepatocellular carcinoma. Frontiers in immunology, 2022, Volume: 13 Topics: Apoptosis; Carcinoma, Hepatocellular; Copper; CTLA-4 Antigen; DNA Copy Number Variations; Humans; Imatinib Mesylate; Liver Neoplasms; Methotrexate; Prognosis; Sorafenib; Tumor Microenvironment	2022
Mn-SOD alleviates methotrexate-related hepatocellular injury via GSK-3β affecting anti-oxidative stress of HO-1 and Drp1. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022, Sep-28, Volume: 47, Issue:9 Topics: Carcinoma, Hepatocellular; Dynamins; Glycogen Synthase Kinase 3 beta; Humans; Liver Neoplasms; Methotrexate; MicroRNAs; Oxidative Stress; Superoxide Dismutase; Superoxides	2022
Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells. Bioscience reports, 2020, 06-26, Volume: 40, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Carcinoma, Hepatocellular; Cell Proliferation; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Flavanones; Hep G2 Cells; Humans; Inflammation Mediators; Liver; Liver Neoplasms; Male; Methotrexate; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats	2020
Methotrexate-associated Lymphoproliferative Disorder in the Liver Resembling Hepatocellular Carcinoma Treated with Transarterial Chemoembolization. Internal medicine (Tokyo, Japan), 2020, Sep-15, Volume: 59, Issue:18 Topics: Aged; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Diagnosis, Differential; Female; Humans; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoproliferative Disorders; Methotrexate	2020
Oxidative phosphorylation activation is an important characteristic of DOX resistance in hepatocellular carcinoma cells. Cell communication and signaling : CCS, 2018, 02-05, Volume: 16, Issue:1 Topics: Adenosine Triphosphate; ATP Synthetase Complexes; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Deoxyglucose; Doxorubicin; Drug Resistance, Neoplasm; Energy Metabolism; Glycolysis; Humans; Ketone Oxidoreductases; Liver Neoplasms; Malates; Methotrexate; Oxidative Phosphorylation	2018
Accelerated Progression of Hepatocellular Carcinoma during Immunosuppressive Therapy with Abatacept for Rheumatoid Arthritis. Internal medicine (Tokyo, Japan), 2019, Jan-01, Volume: 58, Issue:1 Topics: Abatacept; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Carcinoma, Hepatocellular; Disease Progression; Female; Humans; Immunosuppressive Agents; Liver Neoplasms; Methotrexate	2019
Methotrexate and 5-aminoimidazole-4-carboxamide riboside exert synergistic anticancer action against human breast cancer and hepatocellular carcinoma. Acta pharmacologica Sinica, 2013, Volume: 34, Issue:7 Topics: Aminoimidazole Carboxamide; Animals; Apoptosis; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Proliferation; Drug Synergism; Female; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; MCF-7 Cells; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Xenograft Model Antitumor Assays	2013
Inherent and acquired resistance to paclitaxel in hepatocellular carcinoma: molecular events involved. PloS one, 2013, Volume: 8, Issue:4 Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Caveolin 1; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Fatty Acid Synthases; Humans; Liver Neoplasms; Methotrexate; Paclitaxel; Vinblastine	2013
pH-sensitive pullulan-based nanoparticle carrier of methotrexate and combretastatin A4 for the combination therapy against hepatocellular carcinoma. Biomaterials, 2013, Volume: 34, Issue:29 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Delayed-Action Preparations; Glucans; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Liver; Liver Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Molecular; Nanoparticles; Stilbenes	2013
[A case of intraventricular dissemination arising from hepatocelullar carcinoma effectively treated with intrathecal administration of methotrexate]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2014, Volume: 111, Issue:6 Topics: Aged; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cerebral Ventricle Neoplasms; Humans; Injections, Spinal; Liver Neoplasms; Male; Methotrexate	2014
Vitamin C enhances anticancer activity in methotrexate‑treated Hep3B hepatocellular carcinoma cells. Oncology reports, 2014, Volume: 32, Issue:3 Topics: Antimetabolites, Antineoplastic; Ascorbic Acid; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Liver Neoplasms; Methotrexate; Oxygen	2014
Core-shell nanoparticles based on pullulan and poly(β-amino) ester for hepatoma-targeted codelivery of gene and chemotherapy agent. ACS applied materials & interfaces, 2014, Volume: 6, Issue:21 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Drug Carriers; Glucans; Green Fluorescent Proteins; Hep G2 Cells; Humans; Liver Neoplasms; Methotrexate; Mice; Mice, Nude; Nanoparticles; Particle Size; Polymers; Transfection; Xenograft Model Antitumor Assays	2014
Spatial controlled multistage nanocarriers through hybridization of dendrimers and gelatin nanoparticles for deep penetration and therapy into tumor tissue. Nanomedicine : nanotechnology, biology, and medicine, 2017, Volume: 13, Issue:4 Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dendrimers; Drug Delivery Systems; Drug Liberation; Gelatin; Humans; Liver Neoplasms; Male; Matrix Metalloproteinase 2; Methotrexate; Mice, Nude; Nanoparticles; Neoplasms, Experimental; Spheroids, Cellular	2017
Regulation of CMV promoter-driven exogenous gene expression with doxorubicin in genetically modified cells. The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:12 Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cytomegalovirus; DNA, Complementary; Doxorubicin; Fibroblasts; Gene Expression Regulation; Genetic Therapy; Green Fluorescent Proteins; Humans; Methotrexate; Promoter Regions, Genetic; Rats; RNA, Messenger; Time Factors; Transfection	2008
Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor. Brain research bulletin, 2010, Mar-16, Volume: 81, Issue:4-5 Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Brain Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Feeding Behavior; Hippocampus; Immunohistochemistry; Liver Neoplasms; Male; Methotrexate; Neoplasm Transplantation; Pica; Rats; Rats, Inbred BUF	2010
Comparison of the multi-drug resistant human hepatocellular carcinoma cell line Bel-7402/ADM model established by three methods. Journal of experimental & clinical cancer research : CR, 2010, Aug-20, Volume: 29 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Glutathione; Glutathione Transferase; Humans; Inhibitory Concentration 50; Liver Neoplasms; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Multidrug Resistance-Associated Proteins; Organoplatinum Compounds; Time Factors; Xenograft Model Antitumor Assays	2010
Interaction between Gambogic acid and dihydrofolate reductase and synergistic lethal effects with methotrexate on hepatoma cells. Anticancer research, 2013, Volume: 33, Issue:1 Topics: Animals; Carcinoma, Hepatocellular; Cell Death; Drug Resistance, Neoplasm; Drug Synergism; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Melanoma, Experimental; Methotrexate; Mice; Pancreatic Neoplasms; Rats; Tetrahydrofolate Dehydrogenase; Xanthones	2013
Best of the AASLD. Highlights from the 52nd Annual Meeting of the American Association for the Study of Liver Diseases. November 9-13, 2001, Dallas, TX. Reviews in gastroenterological disorders, 2002, Volume: 2, Issue:1 Topics: Carcinoma, Hepatocellular; Cholangitis, Sclerosing; Disease Progression; Hepatitis; Hepatitis, Viral, Human; Humans; Hypertension, Portal; Liver; Liver Cirrhosis, Biliary; Liver Diseases; Liver Neoplasms; Liver Transplantation; Methotrexate	2002
[The binding characteristics of insulin-MTX to insulin receptor]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 2001, Volume: 32, Issue:4 Topics: Antimetabolites, Antineoplastic; Binding Sites; Carcinoma, Hepatocellular; Cell Membrane; Cell Separation; Drug Carriers; Humans; Insulin; Liver Neoplasms; Methotrexate; Receptor, Insulin	2001
Sulfate conjugating and transport functions of MDCK distal tubular cells. Kidney international, 2003, Volume: 63, Issue:3 Topics: Animals; Biological Transport; Buthionine Sulfoximine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclosporine; Glutathione; Harmine; Humans; Immunosuppressive Agents; Kidney Tubules, Distal; Leukotriene Antagonists; Liver; Membrane Transport Proteins; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Probenecid; Propionates; Quinolines; Radiation-Protective Agents; Radiation-Sensitizing Agents; Sulfates; Uricosuric Agents	2003
Metabolism of C136-dichloromethotrexate by transplantable liver tumors. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1962, Volume: 111 Topics: Carcinoma, Hepatocellular; Folic Acid Antagonists; Liver; Liver Neoplasms; Methotrexate	1962
PRIMARY CARCINOMA ARISING IN NORMAL LIVER IN A BOY AGED 7. Proceedings of the Royal Society of Medicine, 1964, Volume: 57 Topics: Carcinoma; Carcinoma, Hepatocellular; Child; Diagnosis, Differential; Hepatectomy; Humans; Liver Neoplasms; Male; Methotrexate; Neoplasms; Pathology; Teratoma	1964
HEPATIC TUMOURS IN CHILDHOOD AND THEIR TREATMENT BY MAJOR HEPATIC RESECTION. Archives of disease in childhood, 1965, Volume: 40 Topics: Carcinoma; Carcinoma, Hepatocellular; Child; Hamartoma; Hepatectomy; Humans; Infant; Liver Neoplasms; Methotrexate; Mortality; Neoplasms; Pathology; Postoperative Complications; Prognosis	1965
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA. Cancer research, 1965, Volume: 25 Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil	1965
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. II. THYMIDINE UPTAKE IN SUSPENSION CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA. Cancer research, 1965, Volume: 25 Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; DNA; DNA, Neoplasm; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Neoplasms, Experimental; Pharmacology; Pyrimidines; Radiometry; Rats; Research; Thymidine; Tritium	1965
A RADIOENZYMATIC ASSAY FOR FOLIC ACID ANTAGONISTS IN BIOLOGICAL FLUIDS. The Journal of laboratory and clinical medicine, 1965, Volume: 66 Topics: Biological Assay; Blood; Carcinoma, Hepatocellular; Cerebrospinal Fluid; Chromatography; Folic Acid Antagonists; Humans; Leukemia; Liver Neoplasms; Methotrexate; Oxidoreductases; Research; Urine	1965
[A report of two cases--two patients of the extremely advanced hepatocellular carcinoma have responded completely for a long time after a combination therapy consisting of arterial chemotherapy and injection of interferon-alpha]. Gan to kagaku ryoho. Cancer & chemotherapy, 2003, Volume: 30, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Fluorouracil; Hepatitis C; Humans; Infusions, Intra-Arterial; Injections, Subcutaneous; Interferon-alpha; Liver Neoplasms; Male; Methotrexate; Prognosis; Remission Induction	2003
Receptor binding characteristics and cytotoxicity of insulin-methotrexate. World journal of gastroenterology, 2004, Aug-15, Volume: 10, Issue:16 Topics: Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Survival; Chromatography, Gel; Chromatography, High Pressure Liquid; Drug Carriers; Hepatocytes; Humans; Insulin; Liver Neoplasms; Methotrexate; Receptor, Insulin	2004
Prolonged perturbation of the oscillations of hepatoma Fao cell proliferation by a single small dose of methotrexate. Pathologie-biologie, 2005, Volume: 53, Issue:5 Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Folic Acid Antagonists; Liver Neoplasms; Methotrexate; Nonlinear Dynamics; Oscillometry; Rats	2005
The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells. Biochimica et biophysica acta, 2005, Aug-30, Volume: 1715, Issue:1 Topics: Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Folic Acid; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Membrane Transport Proteins; Methotrexate; Reduced Folate Carrier Protein; RNA, Small Interfering; Transfection	2005
[Establishment of a multidrug-resistant cell line BEL-7402/5-FU of human hepatocellular carcinoma and its biological characteristics]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2006, Volume: 4, Issue:3 Topics: Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Humans; Liver Neoplasms; Methotrexate; Vincristine	2006
Downregulation of xIAP expression by small interfering RNA inhibits cellular viability and increases chemosensitivity to methotrexate in human hepatoma cell line HepG2. Journal of chemotherapy (Florence, Italy), 2006, Volume: 18, Issue:5 Topics: Antimetabolites, Antineoplastic; Apoptosis; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Genetic Vectors; Humans; Liver Neoplasms; Methotrexate; Molecular Sequence Data; RNA, Small Interfering; Sequence Homology, Nucleic Acid; Substrate Specificity; X-Linked Inhibitor of Apoptosis Protein	2006
Evidence of a novel antiapoptotic factor: role of inhibitor of differentiation or DNA binding (Id-1) in anticancer drug-induced apoptosis. Cancer science, 2007, Volume: 98, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cell Survival; Cisplatin; Down-Regulation; Doxorubicin; Etoposide; Female; HeLa Cells; Humans; Inhibitor of Differentiation Protein 1; Liver Neoplasms; Male; Mechlorethamine; Methotrexate; Mitomycin; Nasopharyngeal Neoplasms; Paclitaxel; Prostatic Neoplasms; Vincristine	2007
Further experience in treating patients with hepatocellular carcinoma in Uganda. Cancer, 1980, Dec-15, Volume: 46, Issue:12 Topics: Adolescent; Adult; Aged; alpha-Fetoproteins; Azacitidine; Carcinoma, Hepatocellular; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Hepatic Artery; Humans; Injections, Intravenous; Ligation; Liver Neoplasms; Male; Methotrexate; Middle Aged; Pigmentation Disorders; Razoxane; Uganda	1980
Model for specific rescue of normal hepatocytes during methotrexate treatment of hepatic malignancy. Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:10 Topics: alpha-Fetoproteins; Asialoglycoprotein Receptor; Asialoglycoproteins; Carcinoma, Hepatocellular; Cells, Cultured; Fetuins; Glycoproteins; Humans; Leucovorin; Liver; Liver Neoplasms; Methotrexate; Receptors, Cell Surface	1983
Membrane characteristics of primary hepatocyte cultures and a stable hepatocarcinoma cell line. Annals of the New York Academy of Sciences, 1980, Volume: 349 Topics: Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Liver; Liver Neoplasms; Male; Methotrexate; Microtubules; Orosomucoid; Rats; Receptors, Cell Surface; Tetrahydrofolates	1980
Chemotherapy of vinyl chloride-associated hepatic angiosarcoma. Cancer, 1981, Feb-01, Volume: 47, Issue:3 Topics: Adult; Carcinoma, Hepatocellular; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Hemangiosarcoma; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Occupational Diseases; Vinyl Chloride; Vinyl Compounds	1981
Evaluation of weekly escalating doses of dichloromethotrexate in patients with hepatocellular carcinoma and other solid tumors. Cancer chemotherapy and pharmacology, 1982, Volume: 8, Issue:3 Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Drug Administration Schedule; Female; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Protein Binding; Serum Albumin	1982
Mechanisms of immunological eradication of a syngeneic guinea pig tumor. II. Effect of methotrexate treatment and T cell depletion of the recipient on adoptive immunity. Transplantation, 1983, Volume: 35, Issue:1 Topics: Animals; BCG Vaccine; Carcinoma, Hepatocellular; Guinea Pigs; Hypersensitivity, Delayed; Immunization, Passive; Liver Neoplasms; Lymphocyte Activation; Lymphocyte Depletion; Male; Methotrexate; Spleen; T-Lymphocytes	1983
Regulation of the ectopically expressed human glycoprotein alpha-subunit gene in the human hepatoma cell line NPLC. Endocrinology, 1994, Volume: 134, Issue:2 Topics: Carcinoma, Hepatocellular; Cell Line; Colforsin; Dexamethasone; Gene Expression Regulation, Neoplastic; Glycoprotein Hormones, alpha Subunit; Humans; Hydroxyurea; Kinetics; Liver Neoplasms; Methotrexate; Protein Kinase C; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured	1994
Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs. Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:2 Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Biological Transport; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Fluorouracil; Humans; KB Cells; Liver Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Mitomycin; Spiro Compounds; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine	1995
Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. The Journal of biological chemistry, 1995, Feb-17, Volume: 270, Issue:7 Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Carcinoma, Hepatocellular; Carrier Proteins; CHO Cells; Cricetinae; DNA, Complementary; Female; Folate Receptors, GPI-Anchored; Genetic Complementation Test; Humans; Kinetics; Liver Neoplasms; Methotrexate; Mice; Molecular Sequence Data; Mutagenesis; Phenotype; Plasmids; Receptors, Cell Surface; Sequence Homology, Amino Acid; Transfection; Tumor Cells, Cultured	1995
Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. The Journal of clinical investigation, 1997, Feb-01, Volume: 99, Issue:3 Topics: Antibodies, Blocking; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Bleomycin; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Cisplatin; Cytotoxicity Tests, Immunologic; DNA Fragmentation; DNA, Complementary; Drug Resistance, Neoplasm; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Genes, p53; Humans; Immunohistochemistry; In Situ Hybridization; Membrane Glycoproteins; Methotrexate; Microinjections; Polymerase Chain Reaction; RNA, Messenger	1997
[A case report of hepatocellular carcinoma with hepatic and portal venous tumor thrombus and multiple intrahepatic metastasis who survived over 1 year after the operation with combined locoregional chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy, 1999, Volume: 26, Issue:12 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Embolization, Therapeutic; Fluorouracil; Hepatectomy; Humans; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Methotrexate; Neoplasm Invasiveness; Neoplastic Cells, Circulating; Portal Vein	1999
Inhibition of P-glycoprotein expression and reversal of drug resistance of human hepatoma HepG2 cells by multidrug resistance gene (mdr1) antisense RNA. Life sciences, 2000, Sep-15, Volume: 67, Issue:17 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Survival; Cloning, Molecular; Doxorubicin; Drug Resistance, Multiple; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Methotrexate; RNA, Antisense; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Vincristine	2000
The effect of methotrexate on actin and invasiveness of hepatoma Morris 5123 cells in culture. Acta biochimica Polonica, 2001, Volume: 48, Issue:4 Topics: Actins; Animals; Antimetabolites, Antineoplastic; Biocompatible Materials; Carcinoma, Hepatocellular; Cell Movement; Collagen; Cytoplasm; Cytosol; Dose-Response Relationship, Drug; Drug Combinations; Laminin; Methotrexate; Microscopy, Fluorescence; Neoplasm Invasiveness; Proteoglycans; Rats; Tumor Cells, Cultured	2001
Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes. Journal of the National Cancer Institute, 1975, Volume: 54, Issue:1 Topics: Animals; Betaine; Carcinogens; Carcinoma, Hepatocellular; Choline; Diet; Ethanolamines; Folic Acid; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methotrexate; Neoplasms, Experimental; Nitrosamines; Organ Size; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Vitamin B 12	1975
Chemotherapeutic drugs increase killing of tumor cells by antibody and complement. Science (New York, N.Y.), 1975, Apr-04, Volume: 188, Issue:4183 Topics: Animals; Antigen-Antibody Reactions; Antineoplastic Agents; Azacitidine; Carcinoma, Hepatocellular; Cell Line; Complement System Proteins; Cyclophosphamide; Cytarabine; Fluorouracil; Guinea Pigs; Liver Neoplasms; Methotrexate; Neoplasms, Experimental; Nitrosamines; Vincristine	1975
Enhancing effect by metabolic inhibitors on the killing of tumor cells by antibody and complement. Cancer research, 1975, Volume: 35, Issue:11 Pt 1 Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Reactions; Antineoplastic Agents; Azacitidine; Carcinoma, Hepatocellular; Cells, Cultured; Complement System Proteins; Cyclophosphamide; Cytarabine; Dactinomycin; Doxorubicin; Fluorouracil; Guinea Pigs; Hydroxyurea; Liver Neoplasms; Mercaptopurine; Methotrexate; Mitomycins; Neoplasms, Experimental; Puromycin; Vincristine	1975
Effect of metabolic inhibitors on the ability of tumor cells to express antigen and bind complement components C4 and C3. Cancer research, 1975, Volume: 35, Issue:11 Pt 1 Topics: Animals; Antigen-Antibody Reactions; Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Binding Sites, Antibody; Carcinoma, Hepatocellular; Cell Membrane; Cells, Cultured; Complement C3; Complement C4; Complement System Proteins; Dactinomycin; Doxorubicin; Guinea Pigs; Liver Neoplasms; Methotrexate; Neoplasms, Experimental; Puromycin	1975
Recent trends in chemotherapy of solid tumors. The Medical clinics of North America, 1975, Volume: 59, Issue:2 Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Cyclophosphamide; Esophageal Neoplasms; Female; Fluorouracil; Gastrointestinal Neoplasms; Head and Neck Neoplasms; Humans; Liver Neoplasms; Lung Neoplasms; Melanoma; Methotrexate; Neoplasms; Pancreatic Neoplasms; Radiotherapy, High-Energy; Sarcoma; Urogenital Neoplasms	1975
Current status of regional arterial infusion chemotherapy. The Medical clinics of North America, 1975, Volume: 59, Issue:2 Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carotid Arteries; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Hepatic Artery; Humans; Liver Neoplasms; Melanoma; Methotrexate; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasms; Temporal Arteries; Time Factors	1975
Future prospects for immunotherapy. Cancer, 1975, Volume: 36, Issue:2 Topics: Animals; BCG Vaccine; Carcinoma, Hepatocellular; Dacarbazine; Guinea Pigs; Humans; Immunotherapy; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Liver Neoplasms; Melanoma; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Sarcoma	1975
[Carcinoma of the liver in a child after seven-year complete remission of acute lymphoblastic leukaemia(author's transl)]. Deutsche medizinische Wochenschrift (1946), 1975, Sep-05, Volume: 100, Issue:36 Topics: Carcinoma, Hepatocellular; Child; Female; Humans; Leukemia, Lymphoid; Liver Cirrhosis; Liver Neoplasms; Mercaptopurine; Methotrexate; Remission, Spontaneous; Time Factors	1975
The experience with clinical application of hydron pouches in tumor chemotherapy. Neoplasma, 1975, Volume: 22, Issue:3 Topics: Autopsy; Carcinoma, Hepatocellular; Child, Preschool; Cyclophosphamide; Drug Implants; Female; Gels; Humans; Infant; Liver; Liver Neoplasms; Male; Methacrylates; Methotrexate	1975
[Tomizine--a new inhibitor of folate metabolism enzymes possessing an antitumor activity]. Voprosy onkologii, 1975, Volume: 21, Issue:11 Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Folic Acid Antagonists; Leukemia L1210; Leukemia, Experimental; Liver Neoplasms; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Neoplasms, Experimental; Rats; Sarcoma 37; Sarcoma, Experimental; Thiazines	1975
Regression of established tumors and induction of tumor immunity by intratumor chemotherapy. Journal of the National Cancer Institute, 1976, Volume: 56, Issue:4 Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Carmustine; Dacarbazine; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Graft Rejection; Guinea Pigs; Injections; Injections, Intraperitoneal; Liver Neoplasms; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Neoplasm Transplantation; Neoplasms, Experimental	1976
Enzyme pattern directed chemotherapy. The effects of combinations of methotrexate, 5-fluorodeoxyuridine and thymidine on rat hepatoma cells in vitro. Biochemical pharmacology, 1976, Dec-01, Volume: 25, Issue:23 Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Cell Line; Depression, Chemical; Floxuridine; Liver Neoplasms; Methotrexate; Rats; Thymidine; Time Factors	1976
Thymidylate synthetase activity in the Novikoff hepatoma. Cancer research, 1976, Volume: 36, Issue:12 Topics: Animals; Carcinoma, Hepatocellular; Cycloheximide; Dactinomycin; Folic Acid; Liver Neoplasms; Male; Methotrexate; Methyltransferases; Neoplasms, Experimental; Puromycin; Rats; Tetrahydrofolates; Thymidylate Synthase	1976
Growth rate of cultured Novikoff rat hepatoma cells as a function of the rate of thymidine and hypoxanthine transport. The Journal of membrane biology, 1977, Jun-06, Volume: 34, Issue:2-3 Topics: Adenosine; Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; Dipyridamole; Guanosine; Hypoxanthines; Liver Neoplasms; Methotrexate; Neoplasms, Experimental; Rats; Thymidine; Thymine Nucleotides	1977
Hepatoma in a child with methotrexate-induced hepatic fibrosis. JAMA, 1977, Dec-12, Volume: 238, Issue:24 Topics: Carcinoma, Hepatocellular; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Lymphoid; Liver; Liver Cirrhosis; Liver Neoplasms; Methotrexate	1977
Chemotherapy studies in autochthonous rat tumors: hepatomas. Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1977, Nov-18, Volume: 90, Issue:2 Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Liver Neoplasms; Methotrexate; Neoplasms, Experimental; Nitrosamines; Rats; Time Factors	1977
Treatment of primary liver cancer: response to regional chemotherapy. Clinical oncology, 1979, Volume: 5, Issue:1 Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Doxorubicin; Female; Floxuridine; Fluorouracil; Hepatectomy; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Prognosis	1979
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism. Cancer research, 1992, Apr-15, Volume: 52, Issue:8 Topics: Acyltransferases; Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Male; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	1992
[Hepatocellular carcinoma in a patient with psoriasis and methotrexate-induced cirrhosis]. Gastroenterologie clinique et biologique, 1991, Volume: 15, Issue:5 Topics: Carcinoma, Hepatocellular; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Methotrexate; Middle Aged; Psoriasis	1991
Low-dose methotrexate therapy for hepatoblastoma. Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:3 Topics: Carcinoma, Hepatocellular; Child, Preschool; Drug Evaluation; Female; Humans; Infant; Liver Neoplasms; Male; Methotrexate	1991
[Histopathologic study on resected hepatocellular carcinoma after transcatheter hepatic arterial chemo-embolization]. Zhonghua yi xue za zhi, 1991, Volume: 71, Issue:7 Topics: Adult; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Female; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver; Liver Neoplasms; Male; Methotrexate; Microspheres; Middle Aged; Mitomycin	1991
The effect of methotrexate on the folate coenzyme pools in human hepatoma cells in culture. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Deoxyuridine; Folic Acid; Glycine; Humans; Kinetics; Liver Neoplasms; Methotrexate; Tritium; Tumor Cells, Cultured	1991
Folate analogues. 33. Synthesis of folate and antifolate poly-gamma-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma Journal of medicinal chemistry, 1990, Volume: 33, Issue:2 Topics: Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry; Chemistry, Physical; Drug Resistance; Extracellular Space; Folic Acid Antagonists; Humans; In Vitro Techniques; Liver Neoplasms; Methotrexate; Polyglutamic Acid; Tumor Cells, Cultured	1990
Toxicities of trichosanthin and alpha-momorcharin, abortifacient proteins from Chinese medicinal plants, on cultured tumor cell lines. Toxicon : official journal of the International Society on Toxinology, 1990, Volume: 28, Issue:10 Topics: Abortifacient Agents, Nonsteroidal; Animals; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Cell Division; Cell Line; Choriocarcinoma; Chorionic Gonadotropin; Cisplatin; Drugs, Chinese Herbal; Fluorouracil; Humans; Liver Neoplasms; Melanoma; Methotrexate; Plant Proteins; Progesterone; Ribosomal Proteins; Ribosome Inactivating Proteins; Trichosanthin; Tumor Cells, Cultured	1990
Rapid chemosensitivity assay with human normal and tumor cells in vitro. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1990, Volume: 26, Issue:11 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Screening Assays, Antitumor; Fibroblasts; Fluorouracil; Humans; Keratinocytes; Liver Neoplasms; Melanocytes; Melanoma; Methotrexate; Neutral Red; Time Factors; Tumor Cells, Cultured	1990
Hepatocellular carcinoma in a long-term survivor of acute lymphocytic leukemia. Cancer, 1987, Nov-15, Volume: 60, Issue:10 Topics: Adult; alpha 1-Antitrypsin; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Female; Humans; Leukemia, Lymphoid; Liver Cirrhosis; Liver Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Proteins; Neoplasms, Multiple Primary	1987
Prognostic factors in patients with hepatocellular carcinoma receiving systemic chemotherapy. Identification of two groups of patients with prospects for prolonged survival. The American journal of medicine, 1985, Volume: 78, Issue:3 Topics: Adolescent; Adult; Aged; alpha-Fetoproteins; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Doxorubicin; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Prognosis; Streptozocin; Time Factors	1985
I foetoprotein and children's cancer. Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research, 1971, Volume: 16, Issue:5 Topics: Alpha-Globulins; Carcinoma, Hepatocellular; Fetal Proteins; Liver Neoplasms; Male; Methotrexate; Prognosis; Retroperitoneal Neoplasms; Sacrococcygeal Region; Teratoma; Testicular Neoplasms	1971
Serum alpha-fetoprotein as a biochemical marker for hepatocellular carcinoma. Cancer research, 1972, Volume: 32, Issue:9 Topics: Adolescent; Adult; Age Factors; Alpha-Globulins; Blood Transfusion; Carcinoma, Hepatocellular; Female; Fetal Proteins; Fluorouracil; Hepatectomy; Humans; Immunodiffusion; Liver Neoplasms; Male; Methotrexate; Middle Aged; Nitrosourea Compounds; Sex Factors; Time Factors	1972
Continuous arterial infusion chemotherapy. Experience with 44 cases. The American surgeon, 1967, Volume: 33, Issue:8 Topics: Adenocarcinoma; Arteries; Brain Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Catheterization; Chloramphenicol; Facial Neoplasms; Fever; Fluorouracil; Head and Neck Neoplasms; Humans; Infections; Infusions, Parenteral; Leucovorin; Liver Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Neoplasm Metastasis; Palliative Care; Penicillins; Stomach Neoplasms; Thoracic Neoplasms	1967
[Loco-regional and sequential chemotherapy of advanced cancer]. Bulletins et memoires de la Societe medicale des hopitaux de Paris, 1968, Volume: 119, Issue:10 Topics: Adult; Carcinoma; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Dysgerminoma; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Palliative Care; Rectal Neoplasms; Testicular Neoplasms; Uterine Cervical Neoplasms; Vinblastine	1968
Oral methotrexate therapy of gastrointestinal carcinoma. Surgery, gynecology & obstetrics, 1970, Volume: 130, Issue:2 Topics: Adenocarcinoma; Carcinoma, Hepatocellular; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; Liver Neoplasms; Methotrexate; Palliative Care; Pancreatic Neoplasms; Stomach Neoplasms	1970
Malignant hepatoma in the Bantu. Cancer, 1970, Volume: 25, Issue:6 Topics: Adenoma, Bile Duct; Africa, Eastern; Alanine Transaminase; Antineoplastic Agents; Aspartate Aminotransferases; Black People; Blood Proteins; Carcinoma, Hepatocellular; Clinical Enzyme Tests; Cyclophosphamide; Cytarabine; Dactinomycin; Fluorouracil; gamma-Globulins; Humans; Hydroxyurea; Liver Neoplasms; Male; Mercaptopurine; Methotrexate; Mitomycins; Nitrogen Mustard Compounds; Prednisone; Prognosis; South Africa; Vincristine	1970
The metabolic fate of tritiated methotrexate. II. Absorption and excretion in man. Cancer research, 1965, Volume: 25, Issue:7 Topics: Adult; Blood; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Child; Child, Preschool; Choriocarcinoma; Chromatography; Female; Hodgkin Disease; Humans; Leukemia, Lymphoid; Liver Neoplasms; Male; Melanoma; Methotrexate; Middle Aged; Pregnancy; Testicular Neoplasms; Tritium; Urine	1965
Infusion chemotherapy in hepatoma and metastatic liver tumors. American journal of surgery, 1967, Volume: 113, Issue:3 Topics: Adenocarcinoma; Adolescent; Aged; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Parenteral; Leucovorin; Liver Function Tests; Liver Neoplasms; Male; Methotrexate; Middle Aged; Mitomycins; Neoplasm Metastasis; Rectal Neoplasms; Sigmoid Neoplasms	1967
Infusion of liver tumours. British medical journal, 1968, Aug-10, Volume: 3, Issue:5614 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Radioisotopes	1968
Methylation of mammalian DNA: studies on Novikoff hepatoma cells in tissue culture. Journal of molecular biology, 1969, Jun-14, Volume: 42, Issue:2 Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Culture Techniques; Cytosine Nucleotides; DNA; Liver Neoplasms; Methionine; Methotrexate; Methylation; Neoplasms, Experimental; Purines; Pyrimidines; Rats; Thymine	1969
Structural and regulatory aspects of enzymes in chemotherapy. Cancer research, 1969, Volume: 29, Issue:12 Topics: Animals; Asparaginase; Carcinoma, Hepatocellular; Cell Membrane; Humans; Liver; Liver Neoplasms; Mammals; Methotrexate; Triazines	1969
[New route of regulating folic acid metabolism in experimental chemotherapy of leukoses and malignant neoplasms]. Vestnik Akademii meditsinskikh nauk SSSR, 1971, Volume: 26, Issue:3 Topics: Animals; Carcinoma, Hepatocellular; Cycloserine; Female; Folic Acid; Leukemia, Experimental; Liver; Liver Neoplasms; Lymphoma, Non-Hodgkin; Male; Methotrexate; Mice; Neoplasms, Experimental; Pyridoxal Phosphate; Rats; Spleen; Tetrahydrofolate Dehydrogenase; Transferases	1971
Liver tumours in infancy and childhood. The Journal of pathology, 1971, Volume: 103, Issue:2 Topics: Adolescent; Carcinoma, Hepatocellular; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Female; Hamartoma; Hepatectomy; Humans; Infant; Infant, Newborn; Liver Neoplasms; Male; Mesenchymoma; Methotrexate; Rhabdomyosarcoma; Vincristine	1971
Stabilization of dihydrofolate reductase by inhibitors in vivo and in vitro. Annals of the New York Academy of Sciences, 1971, Nov-30, Volume: 186 Topics: Animals; Biodegradation, Environmental; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Chromatography, Gel; Cycloheximide; Drug Stability; Electrophoresis; Enzyme Activation; Folic Acid Antagonists; Humans; Leucovorin; Leukemia L1210; Liver Neoplasms; Methotrexate; Mice; Rats; Tetrahydrofolate Dehydrogenase; Triamterene; Trimethoprim	1971
The apparent induction of thymidylate synthetase by amethopterin. Annals of the New York Academy of Sciences, 1971, Nov-30, Volume: 186 Topics: Animals; Aspartic Acid; Benzoates; Carcinoma, Hepatocellular; Enzyme Induction; Folic Acid; Hepatectomy; Liver; Liver Neoplasms; Liver Regeneration; Methotrexate; Methyltransferases; Neoplasms, Experimental; Quinazolines; Rats; Thymine Nucleotides; Uracil Nucleotides	1971
Capillary tube scanning applied to cell growth kinetics. Science (New York, N.Y.), 1972, Mar-31, Volume: 175, Issue:4029 Topics: Animals; Bromodeoxyuridine; Carcinoma, Hepatocellular; Cell Biology; Cell Count; Cells; Cells, Cultured; Hypoxanthines; Kinetics; Liver Neoplasms; Lymphoma; Methotrexate; Mice; Mitosis; Neoplasms, Experimental; Photometry; Rats; Thymidine	1972
Preliminary clinical trials of dichloromethotrexate (NSC-29630) in hepatocellular carcinoma. Cancer chemotherapy reports, 1972, Volume: 56, Issue:2 Topics: Adolescent; Adult; Aged; Aldehydes; Carcinoma, Hepatocellular; Chlorine; Diarrhea; Erythrocyte Count; Female; Hepatic Artery; Humans; Infusions, Parenteral; Injections, Intravenous; Leukocyte Count; Liver; Liver Function Tests; Liver Neoplasms; Male; Methotrexate; Middle Aged; Oxidoreductases	1972
The surgical management of primary hepatocellular carcinoma in Uganda. The British journal of surgery, 1973, Volume: 60, Issue:7 Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Catheterization; Female; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Liver Neoplasms; Male; Methotrexate; Middle Aged; Uganda	1973
Letter: On the source of "minor thymine" in DNA from a Novik off rat hepatoma cell line. Journal of molecular biology, 1973, Oct-05, Volume: 79, Issue:4 Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chromatography, Paper; Cytosine; Deamination; Deoxycytidine; DNA; Liver; Liver Neoplasms; Methotrexate; Neoplasms, Experimental; Rats; Thymidine; Thymine; Tritium	1973
A filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant. Biochemistry, 1974, Jan-29, Volume: 13, Issue:3 Topics: Animals; Binding Sites; Carcinoma, Hepatocellular; Cell-Free System; Cytoplasm; Deoxyribonucleotides; Drug Resistance, Microbial; Evaluation Studies as Topic; Filtration; Fluorine; Kinetics; Lacticaseibacillus casei; Liver Neoplasms; Methods; Methotrexate; Methyltransferases; Neoplasms, Experimental; Rats; Spectrophotometry; Tetrahydrofolates; Thymidylate Synthase; Tritium; Uracil Nucleotides	1974
[Combined drug-surgical treatment in primary and secondary liver tumors]. Helvetica chirurgica acta, 1974, Volume: 41, Issue:5-6 Topics: Carcinoma, Hepatocellular; Drug Therapy, Combination; Floxuridine; Humans; Injections, Intra-Arterial; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Postoperative Complications; Prognosis; Vincristine	1974