methotrexate has been researched along with Body Weight in 218 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 102 (46.79) | 18.7374 |
| 1990's | 31 (14.22) | 18.2507 |
| 2000's | 30 (13.76) | 29.6817 |
| 2010's | 48 (22.02) | 24.3611 |
| 2020's | 7 (3.21) | 2.80 |
| Authors | Studies |
|---|---|
| Grime, K; Paine, SW | 1 |
| Bai, CG; Chen, Y; Jiang, Y; Li, HY; Li, XH; Lu, J; Zhang, Q | 1 |
| Dahlgren, D; Hellström, PM; Kullenberg, F; Lennernäs, H; Nygren, P; Peters, K; Rosenqvist, E; Sjöblom, M | 1 |
| Beburov, MY; Brovkin, AN; Dyachenko, IA; Frolova, AA; Goryacheva, NA; Kaluzhsky, VE; Kazakov, VA; Murashev, AN; Pakhomova, IA; Rasskazova, EA; Sadovnikova, ES; Shaykhutdinova, ER; Slashcheva, GA; Tukhovskaya, EA | 1 |
| Ayna, A; Caglayan, C; Darendelioğlu, E; Gür, C; Kandemir, FM; Kızıl, HE; Küçükler, S | 1 |
| Endo, T; Fujita, K; Hamaue, N; Hirafuji, M; Hirano, M; Iizuka, K; Machida, M; Machida, T; Obara, Y; Shiga, S; Takano, Y; Taniguchi, M | 1 |
| Acar, E; Eraldemir, FC; Kavram Sarihan, K; Yardimoğlu Yilmaz, M; Yazir, Y | 1 |
| Choi, IA; Lee, EB; Lee, EY; Sagawa, A; Song, YW | 1 |
| Choi, L; Ho, RH; Schulte, RR; Stein, CM; Utreja, N; Van Driest, SL | 1 |
| Delen, O; Uz, YH | 1 |
| Abd El-Twab, SM; Hozayen, WG; Hussein, OE; Mahmoud, AM | 1 |
| Hao, J; Hou, Y; Lin, C; Qian, K; Setrerrahmane, S; Wu, Q; Wu, X; Xu, H; Yu, L | 1 |
| Abdo, M; Fekry, E; Makary, S | 1 |
| Khatri, A; Othman, AA | 1 |
| Chaurasiya, B; Ding, Y; Gong, K; Li, W; Ni, Y; Shen, Y; Webster, TJ; Wu, Y; Zhang, Z; Zhao, P | 1 |
| Almon, RR; DuBois, DC; Jusko, WJ; Liu, DY; Lon, HK; Wang, YL | 1 |
| Cao, X; Chen, C; Hao, L; Li, X; Liu, Q; Sun, Q; Tian, L; Zhang, M; Zhang, X | 1 |
| Bateman, E; Bowen, J; Greenberg, N; Keefe, D; Mayo, B; Plews, E; Schiffrin, E; Stringer, A; Wignall, A | 1 |
| Huang, J; Tannock, IF; Winocur, G; Wojtowicz, JM | 1 |
| Carmo Horta Pinto, F; Cristina Magalhães Santos, M; de Fátima Pereira, A; Gabriela Silva, A; Maciel de A Ribeiro, RI; Mara da Costa, V; Rodrigues Da Silva, G; Vieira Teixeira Vidigal, P | 1 |
| Hamaue, N; Hirafuji, M; Hirano, M; Iizuka, K; Kudo, S; Machida, T; Obara, Y; Takagi, M; Takano, Y | 1 |
| Bertino, JR; Farooqi, IN; Kathari, YK; Tedeschi, PM | 1 |
| Chu, W; Cui, S; Deng, Y; Lei, M; Liao, Y; Yan, M; Zeng, K; Zhang, Z; Zhao, C | 1 |
| Al-Taher, AY; El-Sheikh, AA; Morsy, MA | 1 |
| Biswas, S; Nandakumar, K; Patel, A; Ramalingayya, GV; Shoja, MH | 1 |
| Chiragh, S; Faisal, R; Popalzai, AJ | 1 |
| Chen, KM; Foster, BK; Howe, PR; King, TJ; Lee, AM; Shandala, T; Xian, CJ | 1 |
| Howarth, GS; Musa, NS; Tran, CD | 1 |
| Chen, Y; Cui, L; Cui, Y; Gao, X; Liu, Y; Su, Y | 1 |
| Baker, JF; Cannella, A; Cannon, GW; Caplan, L; Davis, L; Ibrahim, S; Jorgenson, E; Michaud, K; Mikuls, TR; Sauer, BC; Teng, CC | 1 |
| Adeyemi, DH; Akindele, OO; Kunle-Alabi, OT; Oghenetega, BO; Raji, Y | 1 |
| Botsios, C; Caso, F; Costa, L; Filardo, GS; Oliviero, F; Punzi, L; Scarpa, R; Sfriso, P; Spinella, P; Todesco, S | 1 |
| Alshammaa, A; Altaweel, H; Kassem, N; Nader, A; Wilby, KJ; Zahran, N | 1 |
| Armagan, A; Cam, H; Koyuncuoglu, HR; Kutluhan, S; Serel, TA; Soyupek, S; Uz, E; Uzar, E; Yilmaz, HR | 1 |
| Bôle-Feysot, C; Boukhettala, N; Breuillé, D; Claeyssens, S; Coëffier, M; Déchelotte, P; Faure, M; Hassan, A; Lavoinne, A; Le Pessot, F; Leblond, J; Mettraux, C; Vuichoud, J | 1 |
| Iseki, S; Ito, K; Kato, S; Kato, Y; Kubo, Y; Tsuji, A; Wakayama, T | 1 |
| Garssen, J; Hartog, A; Hulsman, J | 1 |
| Baker, D; Beutler, A; Davis, HM; Hu, C; Lee, H; Ling, J; Pendley, C; Vu, T; Wagner, C; Xu, Z; Yan, H; Zhou, H | 1 |
| Butler, RN; Howarth, GS; Lymn, KA; Tooley, KL | 1 |
| Aruoma, OI; Fujii, H; Nishioka, H; Sato, E; Sun, B; Wakame, K | 1 |
| Hamada, K; Horie, T; Ito, K; Maeda, T; Miyazono, Y; Sekine, S | 1 |
| Buwalda, B; Konsman, JP; Koolhaas, JM; Pourtau, L; Schagen, SB; Seigers, R; van Dam, FS | 1 |
| Bauerová, K; Jurčovičová, J; Rovenský, J; Stančíkova, M; Svík, K | 1 |
| Aziz, M; Blum, S; Boukhettala, N; Breuillé, D; Coëffier, M; Déchelotte, P; Ibrahim, A; Saudan, KY; Vuichoud, J | 1 |
| Banerjee, BD; Parvez, S; Pasha, ST; Raisuddin, S; Tabassum, H | 1 |
| Ablin, JN; Aloush, V; Barshack, I; Elkayam, O; Entin-Meer, M; George, J; Oren, S | 1 |
| Hübner, C; Kern, P; Kocherscheidt, L; Pichler, BJ; Schmid, A; Soboslay, PT; Wehrl, H; Wiehr, S | 1 |
| Jena, GB; Kushwaha, S; Ramarao, P; Tripathi, DN; Vikram, A | 1 |
| Baumgartner, SW; Chon, Y; Giannini, EH; Gottlieb, B; Higgins, G; Ilowite, NT; Lovell, DJ; Rabinovich, CE; Reiff, A; Wallace, CA; Zhang, N | 1 |
| Alamir, I; Aziz, M; Boukhettala, N; Breuillé, D; Coëffier, M; Déchelotte, P | 1 |
| Gangula, PR; Mukhopadhyay, S; Pasricha, PJ; Ravella, K | 1 |
| Fardell, JE; Johnston, I; Logge, W; Vardy, J | 1 |
| Boukhettala, N; Breuillé, D; Coëffier, M; Coquerel, Q; Déchelotte, P; Fetissov, SO; Gallas, S; Ibrahim, A; Sinno, MH; Terashi, M | 1 |
| Donahue, H; Fitzpatrick, LR; Frauenhoffer, EE; French, KJ; Green, C; Maines, LW; Mosher, TJ; Paul, E; Smith, CD; Upson, JJ; Zhuang, Y | 1 |
| Heldrup, J; Höglund, P; Jönsson, P; Schrøder, H; Skärby, T | 1 |
| Clark-Vetri, R; Foley, JJ; Raffa, RB; Walker, EA | 1 |
| Bole-Feysot, C; Boukhettala, N; Breuillé, D; Coëffier, M; Coquerel, Q; Déchelotte, P; Fetissov, SO; Sinno, MH; Terashi, M | 1 |
| Cavalcanti, SC; Corrêa, L; Luz, JG | 1 |
| Acedo, SC; Carvalho, Pde O; DeOliveira, CC; Gambero, A; Gotardo, EM; Pedrazzoli, J; Rocha, T | 1 |
| Bejar, J; Ben-Lulu, S; G Coran, A; Mogilner, J; Pollak, Y; Sukhotnik, I | 1 |
| Forien, M; Mahé, E; Marchal, A; Sigal, ML; Sin, C | 1 |
| Han, OK; Jeon, TW; Kim, HJ; Kim, KJ; Kim, SH; Lee, ES; Lee, YS; Park, CW; Shin, SW; Suh, SI; Yang, CH; Yoo, WK | 1 |
| GOLDIN, A; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM | 1 |
| BERENBAUM, MC; BROWN, IN | 1 |
| Baggott, JE; Carlee, JR; Goodson, T; Morgan, SL | 1 |
| Akabane, H; Komai, M; Masuda, T; Nagai, H; Nagao, K; Tanaka, H | 1 |
| Fujiyama, J; Fukuda, K; Hagiwara, A; Ito, T; Kin, S; Nakase, Y; Otsuji, E; Sakakura, C; Takagi, T; Yamagishi, H | 1 |
| Ariyama, H; Baba, E; Harada, M; Kashiwabara, N; Mitsugi, K; Nakamura, M; Nakamura, T; Nakano, S; Tanaka, R | 1 |
| Mutoh, S; Ohkubo, Y; Sasakawa, T; Sasakawa, Y | 1 |
| Bersani-Amado, CA; Bracht, A; Caparroz-Assef, SM; Cuman, RK; Ishii-Iwamoto, EL; Kimura, E; Silva, MA | 1 |
| Balthasar, JP; Lobo, ED | 1 |
| Brauner, R; Chédeville, G; Miranda, M; Prieur, AM; Quartier, P | 1 |
| Harsha, WT; Irwin, R; Kalandarova, E; McNutt, P; Noel, J | 1 |
| Honkanen, V; Kautiainen, H; Lahdenne, P; Tynjälä, P; Vähäsalo, P | 1 |
| Aumente, D; Buelga, DS; García, MJ; Gomez, P; Lukas, JC; Torres, A | 1 |
| Beerling, W; Boogerd, W; Buwalda, B; Koolhaas, JM; Schagen, SB; Seigers, R; van Dam, FS; van Tellingen, O | 1 |
| Breuillé, D; Coëffier, M; Déchelotte, P; Duclos, C; Faure, M; Hubert-Buron, A; Le Pessot, F; Leblond, J; Vuichoud, J | 1 |
| Abraham, P; Kolli, VK; Rabi, S | 1 |
| Burchenal, JH; Butterbaugh, J; Dollinger, M; Giner-Sorolla, A; Stoll, D | 1 |
| Brittle, N; Nicholls, A; Reeve, TS; Richards, M; Vincent, PC | 1 |
| Schouwenburg, PF; Snow, GB; Van Putten, LM | 1 |
| Hughes, KB | 1 |
| Haustein, B; Helbig, W; Kubel, M; Schultze, W; Schwenke, H; Standke, E; Thierbach, V | 1 |
| Boutin, P; Carcassone, Y; Cupissol, D; Michel, FB; Plagne, R; Serrou, B | 1 |
| Batley, F; Chen, TY; Cohen, M; Kakos, G; Kilman, J; Mountain, CF; Sealy, R; Stanley, K; Tucker, RD; Vasko, J; Vincent, RG; Williams, TE; Wilson, HE | 1 |
| Beron, G; Jürgens, H; Winkler, K | 1 |
| Bauer, FC; Broström, LA; Nilsonne, U; Nilsson, OS | 1 |
| Grossie, VB; Loo, TL | 1 |
| Daly, JM; Mihranian, MH; Wang, YM | 1 |
| Akolkar, PN; Gokhale, SV; Gothoskar, BP; Rajeswari, R; Shetty, PA | 1 |
| Copeland, EM; Daly, JM; Dudrick, SJ; Reynolds, HM; Rowlands, BJ | 2 |
| Copeland, EM; Daly, JM; Dudrick, SJ; Reynolds, HM | 1 |
| Barkley, HT; Benjamin, RS; Bodey, GP; Ertel, M; Freeman, MB; Mountain, CF; Smith, TL; Valdivieso, M | 1 |
| Aarbakke, J; Høyem-Johansen, T; Slørdal, L | 1 |
| Lee, YT | 1 |
| Mulder, JH; Smink, T; van Putten, LM | 1 |
| Bennett, A; Berstock, DA; Carroll, MA | 1 |
| Billingsley, ML; Hall, N; Mandel, HG | 1 |
| Miccolis, N | 1 |
| Brennan, MF; Maher, M; Sloan, GM | 1 |
| Grossman, HB; Herr, HW; Kleinert, EL; Lesser, ML; Whitmore, WF | 1 |
| Gall, DG; Hamilton, JR; Taminiau, JA | 1 |
| Lee, KT; Lee, WM; Reiner, JM | 1 |
| Tannock, IF | 1 |
| Coyle, P; Philcox, JC; Rofe, AM; Tilley, MH | 1 |
| Braakhuis, BJ; De Jong, M; Peters, GJ; Pinedo, HM; Smid, K; Van der Wilt, CL | 1 |
| Howes, A; Landy, H; Mullenix, PJ; Schunior, A; Tarbell, NJ; Zengel, AE | 1 |
| Schalinske, KL; Steele, RD | 1 |
| Dursun, N; Erenmemişoğlu, A; Ozkul, Y; Saatçi, C; Süer, C | 1 |
| Karakiulakis, G; Paradelis, AG; Pispirigos, K | 1 |
| Dunkley, PR; Francis, JL; Noltorp, RS; O'Loughlin, EV; Warden, RA | 1 |
| Grigg, A; Harun, MH; Szer, J | 1 |
| Ichikawa, Y; Ide, M; Masuda, C; Mizushima, Y; Nakagawa, M; Suzuki, Y; Uehara, R | 1 |
| Awazu, S; Horie, T; Masubuchi, Y; Nakamaru, M; Narimatsu, S | 1 |
| Bathurst, IC; Foehr, MW; Funk-Archuleta, MA; Hennebold, KL; Tomei, LD | 1 |
| Horie, T; Masubuchi, Y; Nakamaru, M | 1 |
| Kirschner, BS | 1 |
| Lialiaris, T; Maskaleris, T; Triantaphyllidis, C | 1 |
| Agata, K; Iwanaga, T; Kanauchi, O; Mitsuyama, K; Nakamura, T; Saiki, T | 1 |
| Masuda, T; Murakami, Y; Ogasawara, H; Sakauchi, N; Tauchi, K; Yamashita, N; Yamazaki, K | 1 |
| Aota, S; Inoue, N; Itokazu, Y; Nakamura, T; Okazaki, Y; Omata, T; Segawa, Y; Tsuzuike, N | 1 |
| Hartung, G; Heene, DL; Schrenk, HH; Sinn, H; Stehle, G; Wunder, A | 1 |
| Dietrich, A; Ehrlich, W; Grätz, R; Kröger, H; Wild, A | 1 |
| Awazu, S; Fuwa, T; Horie, T; Itakura, Y; Karasawa, C; Kasagi, M; Kikuchi, M; Matsumoto, H; Sugiyama, A | 1 |
| Bardare, M; Bianchi, ML; Cherubini, R; Cimaz, R; Corona, F; Galbiati, E | 1 |
| Nagase, S; Ohkuma, S; Sato, S; Shimosato, K; Watanabe, S | 1 |
| Baughman, RP; Lower, EE; Winget, DB | 1 |
| Dziuba, J; Kleinrok, Z; Patyra, H; Sieklucka-Dziuba, M | 1 |
| Iqbal, MP; Mehboobali, N; Pertani, S; Saeed, SA | 1 |
| Bennoun, M; Briand, P; Caron de Fromentel, C; Gillet, R; Grimber, G; Joulin, V | 1 |
| Hartel, RM; Hoekstra, HJ; Kamps, WA; Sluiter, WJ; van Leeuwen, BL; Veth, RP | 1 |
| Akiyoshi, K; Eguchi, H; Hara, T; Inada, H; Ishii, E; Koga, H; Matsuzaki, A; Miyazaki, S; Nagatoshi, Y; Nakayama, H; Nibu, K; Okamura, J; Take, H; Tamai, Y; Yanai, F | 1 |
| Bittner, C; Feyerabend, T; Peters, SO; Raap, M; Remmert, S; Robins, IH; Sieg, P; Sommer, K; Wiedemann, GJ | 1 |
| Alarcón, GS; Arani, R; Baggott, JE; Bernreuter, WK; Gay, RE; Morgan, SL | 1 |
| de Guevara, CL; De-Miguel, E; Gomez-de-Segura, IA; López, JM; Ortega, M; Vázquez, I | 1 |
| Iqbal, MP; Mehboobali, N; Pervez, S; Sultana, F | 1 |
| Asanuma, Y; Kato, M; Kawai, S; Nagai, K; Sugiura, H | 1 |
| Dedrick, RL; Peale, AL; Young, DM; Zaharko, DS | 1 |
| Jehn, U; Kohlschütter, B | 1 |
| Mulder, JH; van Putten, LM | 1 |
| Hoar, RM; McClain, RM; Woo, DC | 1 |
| Gilles, FH; Merker, PC; Shepard, RF; Walker, MD | 1 |
| Culvenor, J; Harding, B; MacLennan, IC | 1 |
| Custer, RP; Freeman-Narrod, M; Narrod, SA | 1 |
| Basu, TK; Williams, DC | 1 |
| Doumont-Meyvis, M; Leroy, F; Tshibangu, K | 1 |
| Benitez, P; Collins, DN; Gaafar, H; Stahl, W; Turek, G | 1 |
| Nyfors, A; Poulsen, H | 1 |
| Nagy, A; Radulovic, S; Schally, AV; Szoke, B | 1 |
| Janaky, T; Juhasz, A; Nagy, A; Schally, AV; Szepeshazi, K | 1 |
| Broadwater, JR; Jensen, JC; Klimberg, VS; Lang, NP; Nwokedi, E; Pappas, AA; Westbrook, KC | 1 |
| Guss, S; Portnoy, J | 1 |
| Avilés, A; Díaz-Maqueo, JC; García, EL; Guzmán, R; Talavera, A | 1 |
| Devi, CS; Marar, T; Subramaniam, S | 1 |
| Albertsson-Wikland, K; Lannering, B; Màrky, I; Mellander, L | 1 |
| Clark, JR; Ervin, TJ; Fabian, RL; Fitzgerald, TJ; Miller, D; Norris, CM; Posner, MR; Rose, C; Tuttle, SA; Weichselbaum, RR | 1 |
| Bichler, E; Picker, H | 1 |
| Bowen, D; Robbins, TJ; White, RM | 1 |
| Fujii, H; Harada, M; Hosaka, M; Kitajima, N; Noguchi, K; Oshima, H; Takeda, M | 1 |
| Igarashi, H; Inomata, K; Tateno, A | 1 |
| Efimov, ML; Kovalenko, VR; Mustafina, RKh; Panina, TG; Vasil'eva, GS | 1 |
| Atkinson, K; Biggs, J; Chan, P; Downs, K; Norrie, S | 1 |
| Barkley, HT; Benjamin, RS; Bodey, GP; Frankmann, C; Jeffries, DG; McMurtrey, MJ; Murphy, WK; Valdivieso, M; Welch, SR | 1 |
| Buzby, GP; Miller, EE; Mullen, JL; Torosian, MH; Zinnser, KR | 1 |
| Egberts, HJ; Koninkx, JF; Mirck, MH; Mouwen, JM; Stemerdink, AF; van Dijk, JE | 1 |
| Boyd, NF; Goodwin, PJ; Panzarella, T | 1 |
| Gordon, JW; Isola, LM | 1 |
| Bateman, JR; Bulcavage, L; Chlebowski, RT; Luce, J; Reynolds, R; Weiner, JM | 1 |
| Hayes, AA; Kurzman, I; MacEwen, EG; Matus, RE | 1 |
| Bauer, HC; Broström, LA; Nilsson, OS | 1 |
| Ettinger, DS; Finkelstein, DM; Ruckdeschel, JC | 1 |
| Daly, JM; Harvey, LP; Kehoe, JE | 1 |
| Bowen, D; Bui, QQ; Robbins, TJ; Tran, MT | 1 |
| Knobf, MT | 1 |
| Gold, J | 1 |
| Cohen, SC; Gregory, EJ; Mims, CH; Oines, DW | 1 |
| Huntington, MO | 1 |
| Abromowitch, M; Dahl, GV; Dow, LW; Evans, WE; Kalwinsky, DK; Look, AT; Mirro, J; Ochs, J; Pui, CH; Rivera, GK | 1 |
| Buzby, GP; Miller, EE; Mullen, JL; Stein, TP; Torosian, MH; Zinsser, KR | 1 |
| Kawamura, M; Sagawa, T; Shimizu, T; Yamashita, K | 1 |
| Badr, MZ; Chen, TS | 1 |
| Boyd, NF; Campbell, JA; Elhakim, T; Heasman, KZ; Sutherland, HJ | 1 |
| Curd, CD; Manno, JE; Stewart, JJ | 1 |
| Bertino, JR; Skeel, RT | 1 |
| Amborski, GF; Bello, TR; Torbert, BJ | 1 |
| Bonney, WW; Feldbush, TL; Neufeld, SE | 1 |
| Hansen, HH; Holland, JF; McCall, CB; Selawry, OS | 1 |
| Guthrie, D; Way, S | 1 |
| Rivlin, RS | 1 |
| Chan, YK; Feeley, JC; Miller, CE; Wong, KH | 1 |
| Bagshawe, KD; Woods, RJ | 1 |
| Dedrick, RL | 1 |
| Glidewell, OJ; Harley, JB; Hoogstraten, B; Lenhard, RE; Leone, LA; Miller, S; Olson, KB; Owens, AH; Spurr, CL; Townsend, SR | 1 |
| Condit, PT | 1 |
| Hayakawa, T; Higashi, H; Kanai, N; Kuroda, R; Mogami, H; Ushio, Y; Yamada, R | 1 |
| Philips, FS; Sodergren, JE; Sternberg, SS; Vidal, P | 1 |
| Bischoff, KB; Dedrick, R; Zaharko, DS | 1 |
| Ashmore, J; Makulu, DR | 1 |
| Eddy, B; Li, CP; Martino, EC; Prescott, B; Tauraso, NM | 1 |
| Hoffman, J; Post, J | 1 |
| DiMartino, MJ; Misher, A; Walz, DT | 1 |
| Hutchison, DJ; Schmid, FA | 1 |
| Margolis, S; Philips, FS; Sternberg, SS | 1 |
| Bischoff, KB; Dedrick, RL; Longstreth, JA; Zaharko, DS | 1 |
| Hutchison, DJ; Schmid, FA; Shimoyama, M | 1 |
| Pearson, HA; Sunderman, CR | 1 |
| Datko, LJ; Kassarich, J; Rosenthale, ME; Schneider, F | 1 |
| Andrysek, O; Coufalová, H; Jehlicková, M; Motycka, K; Stránská, E | 1 |
| Makulu, DR; Wright, P | 1 |
| Pavlotsky, AJ; Svet-Moldavsky, GJ | 1 |
| Yoshino, T | 2 |
| Mikami, M; Murakami, K; Tsunoda, T; Ueda, Y; Yamamoto, M | 2 |
| Lane, M; Levin, H; Moore, JE; Smith, FE | 1 |
| Cohen, RA; Glatstein, HR; Rosenbaum, EH | 1 |
| Lampert, F | 1 |
3 review(s) available for methotrexate and Body Weight
| Article | Year |
|---|---|
Long-term outcome of treatment with protocols AL841, AL851, and ALHR88 in children with acute lymphoblastic leukemia: results obtained by the Kyushu-Yamaguchi Children's Cancer Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Height; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Growth Disorders; Heart Failure; Hematopoietic Stem Cell Transplantation; Humans; Infant; Japan; Male; Methotrexate; Myelodysplastic Syndromes; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Retrospective Studies; Salvage Therapy; Survival Rate; Survivors; Treatment Outcome; Vincristine | 2001 |
Riboflavin and cancer: a review.
Topics: Adenine Nucleotides; Animals; Azo Compounds; Benz(a)Anthracenes; Body Weight; Cells, Cultured; Epithelium; Folic Acid Antagonists; Humans; Liver; Liver Neoplasms; Methotrexate; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Riboflavin; Riboflavin Deficiency; Transplantation, Homologous | 1973 |
Chemotherapy of neoplastic disease with folate antagonists.
Topics: Acute Disease; Administration, Oral; Adult; Age Factors; Body Weight; Burkitt Lymphoma; Carcinoma, Squamous Cell; Child; Choriocarcinoma; Drug Combinations; Female; Folic Acid Antagonists; Humans; Injections, Intramuscular; Injections, Intravenous; Leukemia; Mercaptopurine; Methotrexate; Prednisone; Pregnancy; Time Factors; Vincristine | 1971 |
12 trial(s) available for methotrexate and Body Weight
| Article | Year |
|---|---|
Population Pharmacokinetics of the TNF-α and IL-17A Dual-Variable Domain Antibody ABT-122 in Healthy Volunteers and Subjects With Psoriatic or Rheumatoid Arthritis: Analysis of Phase 1 and 2 Clinical Trials.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Biological Availability; Body Weight; Double-Blind Method; Female; Healthy Volunteers; Humans; Immunoglobulins; Interleukin-17; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Random Allocation; Tumor Necrosis Factor-alpha; Young Adult | 2018 |
Population pharmacokinetics of golimumab, an anti-tumor necrosis factor-alpha human monoclonal antibody, in patients with psoriatic arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Body Weight; C-Reactive Protein; Double-Blind Method; Drug Interactions; Female; Humans; Male; Methotrexate; Middle Aged; Models, Biological; Nonlinear Dynamics; Smoking; Tissue Distribution; Tumor Necrosis Factor Inhibitors; Young Adult | 2009 |
Effects of long-term etanercept treatment on growth in children with selected categories of juvenile idiopathic arthritis.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Body Height; Body Mass Index; Body Weight; Child; Drug Therapy, Combination; Etanercept; Female; Humans; Immunoglobulin G; Male; Methotrexate; Receptors, Tumor Necrosis Factor; Registries; Treatment Outcome | 2010 |
High dose methotrexate treatment in children with acute lymphoblastic leukaemia may be optimised by a weight-based dose calculation.
Topics: Age Factors; Antimetabolites, Antineoplastic; Body Weight; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Models, Biological; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors | 2011 |
Population pharmacokinetics of high-dose methotrexate in children with acute lymphoblastic leukaemia.
Topics: Adolescent; Age Factors; Alanine Transaminase; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Bayes Theorem; Body Weight; Child; Child, Preschool; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Infant; Infusions, Intravenous; Leucovorin; Male; Metabolic Clearance Rate; Methotrexate; Models, Biological; Monte Carlo Method; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Vitamin B Complex | 2006 |
Parenteral intravenous nutrition (PIVN) as an adjunct to chemotherapy in small cell anaplastic lung carcinoma.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Bone Marrow; Carcinoma, Small Cell; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Gastrointestinal Diseases; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Middle Aged; Parenteral Nutrition; Procarbazine; Random Allocation; Vincristine | 1981 |
Comparison of chemotherapy alone versus chemotherapy and radiation therapy of extensive small cell carcinoma of the lung.
Topics: Aged; Body Weight; Carcinoma, Small Cell; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Leukopenia; Lomustine; Lung Neoplasms; Male; Methotrexate; Middle Aged; Nitrosourea Compounds; Random Allocation; Thrombocytopenia | 1983 |
Toxicity associated with combination chemotherapy for osteosarcoma: a report of the cooperative osteosarcoma study (COSS 80).
Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Agents; Body Weight; Bone Neoplasms; Child; Child, Preschool; Cisplatin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Leucovorin; Leukopenia; Male; Methotrexate; Osteosarcoma | 1983 |
Role of intravenous hyperalimentation as an adjunct to intensive chemotherapy for small cell bronchogenic carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Bone Marrow; Carcinoma, Bronchogenic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Gastrointestinal Diseases; Humans; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neutropenia; Parenteral Nutrition; Procarbazine; Vincristine | 1981 |
Variability in determination of body weight used for dosing busulphan and cyclophosphamide in adult patients: results of an international survey.
Topics: Adult; Body Weight; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Graft vs Host Disease; Humans; Immunosuppressive Agents; Methotrexate; Transplantation Conditioning | 1997 |
Methotrexate is steroid sparing in acute sarcoidosis: results of a double blind, randomized trial.
Topics: Adult; Body Weight; Double-Blind Method; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Prednisone; Sarcoidosis; Sarcoidosis, Pulmonary; Treatment Outcome | 2000 |
Long-term survival following relapse after 5-FU but not CMF adjuvant breast cancer therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Body Weight; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Humans; Mastectomy; Methotrexate; Neoplasm Recurrence, Local; Prognosis; Random Allocation; Time Factors | 1986 |
203 other study(ies) available for methotrexate and Body Weight
| Article | Year |
|---|---|
Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Body Weight; Dogs; Drug Administration Routes; Humans; Liver; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organic Anion Transporters; Pharmaceutical Preparations; Protein Binding; Rats; Species Specificity | 2013 |
Therapeutic effects of isothiocyanate prodrugs on rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Body Weight; Half-Life; Isothiocyanates; Mice; Neutrophils; Prodrugs; Rats, Sprague-Dawley; Rats, Wistar; Zebrafish | 2018 |
Evaluation and validation of chemotherapy-specific diarrhoea and histopathology in rats.
Topics: Animals; Antineoplastic Agents; Atrophy; Body Weight; Diarrhea; Doxorubicin; Fluorouracil; Idarubicin; Intestinal Mucosa; Irinotecan; Male; Methotrexate; Mucositis; Rats; Rats, Wistar | 2022 |
AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.
Topics: AMP-Activated Protein Kinases; Animals; Body Weight; Diabetes Mellitus, Type 2; Diet, High-Fat; Male; Metabolic Syndrome; Methotrexate; Mice; Mice, Inbred C57BL; Ribonucleosides | 2022 |
Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways.
Topics: Animals; Antioxidants; bcl-2-Associated X Protein; Body Weight; Caspase 3; Chemical and Drug Induced Liver Injury; Flavonoids; Liver; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction | 2023 |
Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine.
Topics: Animals; Body Weight; Enterochromaffin Cells; Gene Expression; Hyperplasia; Intestine, Small; Male; Methotrexate; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; RNA, Messenger; Serotonin | 2019 |
Protective effects of apocynin on damaged testes of rats exposed to methotrexate
Topics: Acetophenones; Animals; Antioxidants; Apoptosis; Body Weight; Male; Malondialdehyde; Methotrexate; Peroxidase; Rats; Rats, Wistar; Testis | 2020 |
Tocilizumab Increases Body Weight and Serum Adipokine Levels in Patients with Rheumatoid Arthritis Independently of Their Treatment Response: a Retrospective Cohort Study.
Topics: Adiponectin; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Body Weight; Drug Therapy, Combination; Female; Heart Disease Risk Factors; Humans; Leptin; Male; Methotrexate; Middle Aged; Receptors, Interleukin-6; Resistin; Retrospective Studies; Tumor Necrosis Factor-alpha | 2020 |
Effect of SLCO1B1 Polymorphisms on High-Dose Methotrexate Clearance in Children and Young Adults With Leukemia and Lymphoblastic Lymphoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Leukemia, Lymphoid; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Models, Biological; Pharmacogenomic Testing; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2021 |
Protective effect of pyrrolidine dithiocarbamate against methotrexate-induced testicular damage.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Gonadal Steroid Hormones; Male; Methotrexate; Organ Size; Pyrrolidines; Rats; Rats, Wistar; Testicular Diseases; Testis; Thiocarbamates | 2021 |
Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid.
Topics: Animals; Apoptosis; Body Weight; Down-Regulation; Glycyrrhetinic Acid; Inflammation; Liver; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar | 2017 |
Combination Therapy of PEG-HM-3 and Methotrexate Retards Adjuvant-Induced Arthritis.
Topics: Animals; Arthritis, Experimental; Body Weight; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Gene Expression Regulation; Lipopolysaccharides; Macrophages; Male; Methotrexate; Peptides; Rats; Spleen; Toll-Like Receptor 4; Treatment Outcome; Tumor Necrosis Factor-alpha | 2017 |
Oxidative stress burden inhibits spermatogenesis in adult male rats: testosterone protective effect.
Topics: Aging; Animals; Biomarkers; Body Weight; Estradiol; Follicle Stimulating Hormone; Grape Seed Extract; Inflammation; Letrozole; Male; Methotrexate; Nitriles; Organ Size; Oxidative Stress; Protective Agents; Rats, Sprague-Dawley; Seminiferous Tubules; Sperm Count; Sperm Motility; Spermatogenesis; Testosterone; Triazoles | 2018 |
Effects of triptolide and methotrexate nanosuspensions on left ventricular remodeling in autoimmune myocarditis rats.
Topics: Animals; Body Weight; Collagen; Cytokines; Diterpenes; Epoxy Compounds; Heart Function Tests; Heart Ventricles; Male; Methotrexate; Myocarditis; Myocardium; Nanoparticles; NF-kappa B; Organ Size; Particle Size; Phenanthrenes; Phosphorylation; Rats, Inbred Lew; Signal Transduction; Suspensions; Ventricular Remodeling | 2019 |
Pharmacokinetics, pharmacodynamics and toxicities of methotrexate in healthy and collagen-induced arthritic rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Body Weight; Collagen Type II; Disease Progression; Dose-Response Relationship, Drug; Edema; Inhibitory Concentration 50; Male; Methotrexate; Models, Biological; Rats; Rats, Inbred Lew; Swine; Time Factors | 2013 |
Protective effect of amifostine on high-dose methotrexate-induced small intestinal mucositis in mice.
Topics: Amifostine; Animals; Body Weight; Female; Immunosuppressive Agents; Intestine, Small; Leucovorin; Male; Methotrexate; Mice; Mucositis; Radiation-Protective Agents; Random Allocation; Specific Pathogen-Free Organisms | 2013 |
Investigation of effect of nutritional drink on chemotherapy-induced mucosal injury and tumor growth in an established animal model.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Beverages; Body Weight; Cell Proliferation; Diarrhea; Diet; Disease Models, Animal; Female; Goblet Cells; Methotrexate; Mucositis; Neoplasms; Nutritional Status; Random Allocation; Rats | 2013 |
Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Cognition Disorders; Cues; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Female; Fluorouracil; Housing, Animal; Immunohistochemistry; Learning; Memory; Methotrexate; Microtubule-Associated Proteins; Motor Activity; Neurogenesis; Neuropeptides; Neuropsychological Tests; Rats, Long-Evans; Spatial Memory | 2014 |
Evaluation of the effects of methotrexate released from polymeric implants in solid Ehrlich tumor.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Carcinoma, Ehrlich Tumor; Cell Proliferation; Drug Carriers; Drug Implants; Female; Immunohistochemistry; Methotrexate; Mice; Polyesters | 2014 |
Methotrexate causes a change in intestinal 5-hydroxytryptamine metabolism in rats.
Topics: Animals; Body Weight; Cyclooxygenase 1; Cyclooxygenase 2; Eating; Hydroxyindoleacetic Acid; Ileum; Kaolin; Male; Membrane Proteins; Methotrexate; Peroxidase; Rats, Wistar; RNA-Binding Proteins; RNA, Messenger; Serotonin; Tryptophan Hydroxylase | 2014 |
Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts.
Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Folic Acid Antagonists; Glutamates; Guanine; Humans; Leucovorin; Mesothelioma; Methotrexate; Mice, Nude; Pemetrexed; Time Factors; Tumor Burden; Vitamin B Complex; Xenograft Model Antitumor Assays | 2014 |
Improvement of pharmacokinetic and antitumor activity of layered double hydroxide nanoparticles by coating with PEGylated phospholipid membrane.
Topics: Animals; Antineoplastic Agents; Blood Proteins; Body Weight; Cell Survival; Drug Carriers; HeLa Cells; Humans; Hydroxides; Methotrexate; Mice; Nanoparticles; Particle Size; Phospholipids; Polyethylene Glycols; Rats, Sprague-Dawley; Xenograft Model Antitumor Assays | 2014 |
Multi-drug resistance protein (Mrp) 3 may be involved in resveratrol protection against methotrexate-induced testicular damage.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Body Weight; Cell Line, Tumor; Drug Resistance, Multiple; Humans; Male; Methotrexate; Multidrug Resistance-Associated Proteins; Prostatic Neoplasms; Protective Agents; Rats; Rats, Wistar; Resveratrol; Stilbenes; Testis; Testosterone | 2014 |
Protective effects of aqueous extract of Solanum nigrum Linn. leaves in rat models of oral mucositis.
Topics: Animals; Body Weight; Busulfan; Chromatography, High Pressure Liquid; Disease Models, Animal; Feeding Behavior; Female; Methotrexate; Phytochemicals; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Rats, Wistar; Solanum nigrum; Stomatitis; Survival Analysis; Toxicity Tests, Acute; Water | 2014 |
Anti inflammatory effect of thymoquinone in comparison with methotrexate on pristane induced arthritis in rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzoquinones; Body Weight; Female; Foot Joints; Immunosuppressive Agents; Inflammation; Leukocyte Count; Methotrexate; Random Allocation; Rats; Rats, Sprague-Dawley; Terpenes | 2015 |
Potential Effects of Phytoestrogen Genistein in Modulating Acute Methotrexate Chemotherapy-Induced Osteoclastogenesis and Bone Damage in Rats.
Topics: Adipocytes; Animals; Antimetabolites, Antineoplastic; Body Weight; Bone and Bones; Bone Density; Bone Marrow; Bone Resorption; Gene Expression Regulation; Genistein; Male; Methotrexate; Phytoestrogens; Rats; Rats, Sprague-Dawley | 2015 |
Zinc Supplementation Alone Is Effective for Partial Amelioration of Methotrexate-induced Intestinal Damage.
Topics: Animals; Body Weight; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Mice; Mice, Inbred C57BL; Mucositis; Probiotics; Zinc | 2015 |
Effects of dexamethasone, celecoxib, and methotrexate on the histology and metabolism of bone tissue in healthy Sprague Dawley rats.
Topics: Animals; Antirheumatic Agents; Biomarkers; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Celecoxib; Dexamethasone; Female; Femur; Lumbar Vertebrae; Methotrexate; Osteoporosis; Rats; Rats, Sprague-Dawley; X-Ray Microtomography | 2015 |
Changes in Body Mass Related to the Initiation of Disease-Modifying Therapies in Rheumatoid Arthritis.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Body Weight; Female; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Prednisone; Tumor Necrosis Factor-alpha | 2016 |
Effects of methotrexate on serum testosterone level in sleep deprived male Wistar rats.
Topics: Animals; Body Weight; Follicle Stimulating Hormone; Interleukin-1beta; Luteinizing Hormone; Male; Methotrexate; Rats, Wistar; Sleep Deprivation; Testis; Testosterone | 2015 |
Impact of 24 months of anti-TNF therapy versus methotrexate on body weight in patients with rheumatoid arthritis: a prospective observational study.
Topics: Adalimumab; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Body Weight; Eating; Etanercept; Female; Humans; Italy; Logistic Models; Longitudinal Studies; Male; Methotrexate; Middle Aged; Prospective Studies; Tumor Necrosis Factor-alpha | 2016 |
Population Pharmacokinetics of Intravenous Methotrexate in Patients with Hematological Malignancies: Utilization of Routine Clinical Monitoring Parameters.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Body Weight; Dose-Response Relationship, Drug; Drug Monitoring; Female; Hematocrit; Hematologic Neoplasms; Humans; Male; Methotrexate; Middle Aged; Models, Biological; Nonlinear Dynamics; Qatar; Retrospective Studies; Tissue Distribution; Young Adult | 2017 |
Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Caffeic Acids; Cytotoxins; Drug Antagonism; Injections, Intraperitoneal; Lipid Peroxidation; Male; Malondialdehyde; Methotrexate; Organ Size; Oxidative Stress; Phenylethyl Alcohol; Rats; Rats, Wistar; Superoxide Dismutase; Testis | 2008 |
Methotrexate induces intestinal mucositis and alters gut protein metabolism independently of reduced food intake.
Topics: Amino Acids; Animals; Antimetabolites, Antineoplastic; Body Weight; Cell Growth Processes; Eating; Glutathione; Immunohistochemistry; Intestinal Mucosa; Jejunum; Male; Methotrexate; Mucins; Mucositis; Proteins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2009 |
Involvement of multidrug resistance-associated protein 1 in intestinal toxicity of methotrexate.
Topics: Animals; Antimetabolites, Antineoplastic; Antirheumatic Agents; Body Weight; Gene Knockout Techniques; Intestinal Mucosa; Intestine, Small; Methotrexate; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins | 2009 |
Locomotion and muscle mass measures in a murine model of collagen-induced arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Body Weight; Cachexia; Disability Evaluation; Disease Models, Animal; Disease Progression; Gait Disorders, Neurologic; Image Processing, Computer-Assisted; Locomotion; Male; Methotrexate; Mice; Mice, Inbred DBA; Muscle, Skeletal; Muscular Atrophy; Severity of Illness Index; Treatment Outcome; Video Recording | 2009 |
Optimization of the non-invasive 13C-sucrose breath test in a rat model of methotrexate-induced mucositis.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Breath Tests; Carbon Isotopes; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Female; Intestine, Small; Methotrexate; Mucositis; Organ Size; Rats; Sensitivity and Specificity; Sucrase; Sucrose | 2010 |
The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents.
Topics: Alopecia; Animals; Animals, Newborn; Antimetabolites, Antineoplastic; Body Weight; Cytarabine; Female; Hair Follicle; Male; Mercaptopurine; Methotrexate; Mice; Polysaccharides; Rats; Rats, Sprague-Dawley; Shiitake Mushrooms | 2009 |
Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Body Weight; Dextrans; Fluorescein-5-isothiocyanate; Free Radical Scavengers; Glutathione; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Oxidative Stress; Permeability; Rats; Rats, Wistar; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Time Factors | 2010 |
Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Brain Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Feeding Behavior; Hippocampus; Immunohistochemistry; Liver Neoplasms; Male; Methotrexate; Neoplasm Transplantation; Pica; Rats; Rats, Inbred BUF | 2010 |
The effects of β-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis.
Topics: Animals; Arthritis, Experimental; beta-Glucans; Body Weight; Male; Methotrexate; Pleurotus; Rats; Rats, Inbred Lew; Serum Albumin | 2011 |
A diet containing whey protein, free glutamine, and transforming growth factor-beta ameliorates nutritional outcome and intestinal mucositis during repeated chemotherapeutic challenges in rats.
Topics: alpha-Macroglobulins; Animals; Antineoplastic Agents; Body Composition; Body Weight; Diet; Eating; Glutamine; Immunoglobulin A, Secretory; Jejunum; Male; Methotrexate; Milk Proteins; Mucositis; Orosomucoid; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Whey Proteins | 2010 |
Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria.
Topics: Animals; Body Weight; DNA; Folic Acid Antagonists; Free Radicals; Glutathione; Glutathione Peroxidase; In Vitro Techniques; Lipid Metabolism; Methotrexate; Mice; Mitochondria, Liver; Oxidation-Reduction; Oxidative Stress; Protein Carbonylation; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides; Thiobarbituric Acid Reactive Substances; Thioctic Acid | 2010 |
Protective effect of eotaxin-2 inhibition in adjuvant-induced arthritis.
Topics: Animals; Antibodies, Monoclonal; Arthritis, Experimental; Arthrography; Body Weight; Chemokine CCL24; Dose-Response Relationship, Drug; Drug Therapy, Combination; Freund's Adjuvant; Joints; Locomotion; Male; Methotrexate; Rats; Rats, Inbred Lew; Tarsus, Animal | 2010 |
Effects of in vitro exposure of Echinococcus multilocularis metacestodes to cytostatic drugs on in vivo growth and proliferation of the parasite.
Topics: Animals; Anthelmintics; Autopsy; Body Weight; Cytostatic Agents; Disease Models, Animal; Echinococcosis; Echinococcus multilocularis; Female; Gerbillinae; Magnetic Resonance Imaging; Male; Methotrexate; Vinblastine; Vincristine; Vinorelbine | 2010 |
Evaluation of multi-organ DNA damage by comet assay from 28 days repeated dose oral toxicity test in mice: a practical approach for test integration in regulatory toxicity testing.
Topics: Animals; Body Weight; Brain; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Drinking Behavior; Feeding Behavior; Glutathione; Hematologic Tests; Liver; Male; Malondialdehyde; Methotrexate; Mice; Mutagens; Organ Size | 2010 |
Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis.
Topics: Animals; Body Weight; Cathepsin D; Cathepsins; Chemokines, CXC; Eating; Gene Expression; Inflammation; Interleukin-1beta; Intestinal Mucosa; Leucine; Male; Methotrexate; Mucositis; Pepstatins; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2010 |
Sepiapterin reverses the changes in gastric nNOS dimerization and function in diabetic gastroparesis.
Topics: Animals; Blood Glucose; Body Weight; Diabetic Neuropathies; Dietary Supplements; Dimerization; Female; Gastric Emptying; Gastroparesis; Immunosuppressive Agents; Male; Methotrexate; Nitric Oxide Synthase Type I; Protein Structure, Quaternary; Pterins; Rats; Rats, Sprague-Dawley; Stomach | 2010 |
Single high dose treatment with methotrexate causes long-lasting cognitive dysfunction in laboratory rodents.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Cognition Disorders; Discrimination Learning; Discrimination, Psychological; Injections, Intraperitoneal; Male; Maze Learning; Memory; Methotrexate; Rats; Rats, Wistar; Recognition, Psychology | 2010 |
Chemotherapy-induced anorexia is accompanied by activation of brain pathways signaling dehydration.
Topics: Analysis of Variance; Animals; Anorexia; Antineoplastic Agents; Appetite; Body Weight; Dehydration; Drinking; Hypothalamus; Immunohistochemistry; Interleukin-1beta; Male; Methotrexate; Pro-Opiomelanocortin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Rats, Zucker; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2010 |
Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.
Topics: Adamantane; Administration, Oral; Animals; Ankle; Ankle Joint; Arthritis, Experimental; Body Weight; Drug Therapy, Combination; Edema; Enzyme Inhibitors; Female; Foot; Indomethacin; Inflammation; Methotrexate; Mice; Mice, Inbred DBA; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Inbred Lew; Splenomegaly; X-Ray Microtomography | 2011 |
Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Behavior, Animal; Body Weight; Conditioning, Operant; Dose-Response Relationship, Drug; Fluorouracil; Learning; Male; Memory; Methotrexate; Mice; Mice, Inbred Strains; Selective Estrogen Receptor Modulators; Tamoxifen | 2011 |
Intestinal inflammation influences α-MSH reactive autoantibodies: relevance to food intake and body weight.
Topics: alpha-MSH; Animals; Anorexia; Autoantibodies; Body Weight; Disease Models, Animal; Drinking; Eating; Humans; Immunoglobulin G; Male; Methotrexate; Mucositis; Rabbits; Rats; Rats, Sprague-Dawley | 2012 |
Facial symmetry evaluation after experimentally displaced condylar process fracture in methotrexate treated rats.
Topics: Analysis of Variance; Animals; Body Weight; Cephalometry; Disease Models, Animal; Facial Asymmetry; Immunosuppressive Agents; Joint Dislocations; Male; Mandibular Condyle; Mandibular Fractures; Maxilla; Methotrexate; Radiography; Random Allocation; Rats; Rats, Wistar; Temporomandibular Joint Disorders | 2012 |
Effects of methotrexate on inflammatory alterations induced by obesity: an in vivo and in vitro study.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Adiposity; Animals; Body Weight; Coculture Techniques; Cytokines; Diet, High-Fat; Epididymis; Inflammation; JNK Mitogen-Activated Protein Kinases; Lipolysis; Macrophages; Male; Methotrexate; Mice; Nitric Oxide Synthase Type II; Obesity; Phosphorylation | 2012 |
Dietary transforming growth factor-beta 2 (TGF-β2) supplementation reduces methotrexate-induced intestinal mucosal injury in a rat.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; beta Catenin; Blotting, Western; Body Weight; Caco-2 Cells; Cell Survival; Dietary Supplements; Enterocytes; Humans; Interleukin-1beta; Intestinal Mucosa; Male; Methotrexate; Mucositis; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta2 | 2012 |
[Body-weight changes in psoriatic patients on systemic treatment].
Topics: Adult; Aged; Antibodies, Monoclonal; Arthritis, Psoriatic; Body Weight; Comorbidity; Dermatologic Agents; Female; Humans; Infliximab; Long-Term Care; Male; Methotrexate; Middle Aged; Obesity; Psoriasis; Retrospective Studies; Tumor Necrosis Factor-alpha | 2012 |
Immunomodulatory effects of aqueous-extracted Astragali radix in methotrexate-treated mouse spleen cells.
Topics: Adjuvants, Immunologic; Animals; Body Weight; Cell Division; Cell Separation; Cytokines; Dose-Response Relationship, Drug; Fabaceae; Female; Gene Expression Regulation; Immunosuppressive Agents; Methotrexate; Mice; Mice, Inbred ICR; Mitogens; Oligonucleotide Probes; Organ Size; Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; RNA; Spleen | 2003 |
The influence of amethopterin on the survival time of leukemic mice with respect to food intake, body weight changes, and tumor growth.
Topics: Animals; Body Weight; Eating; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Nutritional Sciences | 1958 |
THE EFFECT OF DELAYED ADMINISTRATION OF FOLINIC ACID ON IMMUNOLOGICAL INHIBITION BY METHOTREXATE.
Topics: Animals; Antibody Formation; Body Weight; Immunosuppressive Agents; Injections, Intraperitoneal; Leucovorin; Methotrexate; Mice; Mortality; Pharmacology; Research; Typhoid-Paratyphoid Vaccines | 1965 |
The energy cost of adjuvant-induced arthritis in rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Body Weight; Eating; Energy Metabolism; Female; Methotrexate; Rats; Rats, Inbred Lew | 2003 |
Effect of MX-68 on airway inflammation and hyperresponsiveness in mice and guinea-pigs.
Topics: 2-Aminoadipic Acid; Acetylcholine; Administration, Inhalation; Allergens; Animals; Body Weight; Bronchial Hyperreactivity; Bronchitis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Immunoglobulins; Injections, Intraperitoneal; Interferon-gamma; Interleukin-4; Interleukin-5; Male; Methotrexate; Mice; Mice, Inbred BALB C; Ovalbumin; Prednisolone | 2004 |
Intratumoral administration of methotrexate bound to activated carbon particles: antitumor effectiveness against human colon carcinoma xenografts and acute toxicity in mice.
Topics: Animals; Autopsy; Body Weight; Charcoal; Colonic Neoplasms; Humans; Lethal Dose 50; Male; Methotrexate; Mice; Mice, Inbred BALB C; Phenotype; Xenograft Model Antitumor Assays | 2004 |
Protection against methotrexate toxicity by a soybean protein- and omega-3 fatty acid-containing diet: comparative study with a casein-containing diet.
Topics: Animals; Appetite; Body Weight; Caseins; Diet; Fatty Acids, Omega-3; Glycine max; Intestinal Mucosa; Male; Methotrexate; Mice; Microvilli; Rats; Rats, Sprague-Dawley; Soybean Proteins | 2004 |
FK506 ameliorates spontaneous locomotor activity in collagen-induced arthritis: implication of distinct effect from suppression of inflammation.
Topics: Animals; Arthritis, Experimental; Body Weight; Female; Femur Head; Hyperalgesia; Immunosuppressive Agents; Inflammation; Methotrexate; Motor Activity; Muscle, Skeletal; Pain; Proteoglycans; Rats; Rats, Inbred Lew; Tacrolimus | 2005 |
Efficiency of combined methotrexate/chloroquine therapy in adjuvant-induced arthritis.
Topics: Acid Phosphatase; Alanine Transaminase; Alkaline Phosphatase; Animals; Arthritis, Experimental; Aspartate Aminotransferases; Body Weight; Chloroquine; Drug Therapy, Combination; Liver; Male; Methotrexate; Rats | 2005 |
Application of anti-methotrexate Fab fragments for the optimization of intraperitoneal methotrexate therapy in a murine model of peritoneal cancer.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Area Under Curve; Body Weight; Combined Modality Therapy; Disease Models, Animal; Half-Life; Immunoglobulin Fab Fragments; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Maximum Tolerated Dose; Methotrexate; Mice; Peritoneal Neoplasms; Sarcoma 180; Survival Rate | 2005 |
Improvements in growth parameters in children with juvenile idiopathic arthritis associated with the effect of methotrexate on disease activity.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Body Height; Body Mass Index; Body Weight; Child; Child Development; Child, Preschool; Female; Growth; Humans; Infant; Male; Methotrexate | 2005 |
Nutritional supplementation with transforming growth factor-beta, glutamine, and short chain fatty acids minimizes methotrexate-induced injury.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Diet; Dietary Supplements; Fatty Acids, Volatile; Glutamine; Intestinal Mucosa; Intestine, Small; Methotrexate; Mucositis; Random Allocation; Rats; Rats, Inbred F344; Transforming Growth Factor beta | 2006 |
Impact of anti-TNF treatment on growth in severe juvenile idiopathic arthritis.
Topics: Adolescent; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Juvenile; Blood Sedimentation; Body Height; Body Mass Index; Body Weight; C-Reactive Protein; Chi-Square Distribution; Child; Etanercept; Female; Growth; Humans; Immunoglobulin G; Infliximab; Male; Methotrexate; Prospective Studies; Receptors, Tumor Necrosis Factor; Retrospective Studies; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Cell Proliferation; Cognition Disorders; Discrimination, Psychological; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hippocampus; Ki-67 Antigen; Male; Maze Learning; Methotrexate; Pattern Recognition, Visual; Rats; Rats, Wistar; Reaction Time | 2008 |
Chemotherapy-induced mucositis is associated with changes in proteolytic pathways.
Topics: Animals; Body Weight; Cell Proliferation; Cytokines; Eating; Glutathione; Intestinal Absorption; Jejunum; Male; Methotrexate; Mucositis; Peptide Hydrolases; Rats; Rats, Sprague-Dawley; Signal Transduction | 2008 |
Methotrexate-induced nitrosative stress may play a critical role in small intestinal damage in the rat.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Duodenum; Ileum; Immunohistochemistry; Injections, Intraperitoneal; Intestine, Small; Jejunum; Male; Methotrexate; Neutrophil Infiltration; Neutrophils; Nitrites; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Reactive Nitrogen Species; Time Factors; Tyrosine | 2008 |
Studies of 6-N-hydroxylamino-9-beta-D-ribofuranosylpurine in mouse leukemia.
Topics: Adenine; Animals; Body Weight; Cytarabine; Drug Antagonism; Drug Synergism; Fluorouracil; Guanine; Leukemia; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Nucleosides; Phosphotransferases; Purines; Vincristine | 1967 |
The effect of cytotoxic drugs on serum albumin in the rat.
Topics: Animals; Blood Protein Disorders; Blood Protein Electrophoresis; Body Weight; Cyclophosphamide; Malabsorption Syndromes; Mechlorethamine; Methotrexate; Mitomycins; Protein-Losing Enteropathies; Rats; Serum Albumin; Serum Globulins; Starvation | 1967 |
External carotid artery infusion with single-and multiple-drug regimens in the rat.
Topics: Animals; Antineoplastic Agents; Bleomycin; Body Weight; Carcinoma, Squamous Cell; Carotid Artery, External; Drug Therapy, Combination; Fluorouracil; Infusions, Intra-Arterial; Male; Methotrexate; Neoplasm Transplantation; Neoplasms, Experimental; Rats | 1980 |
Preliminary report on the effects of a four drug cytoxic protocol on wound healing in the rat.
Topics: Abdomen; Animals; Bleomycin; Body Weight; Drug Administration Schedule; Female; Fluorouracil; Injections, Intraperitoneal; Leucovorin; Methotrexate; Postoperative Period; Rats; Rats, Inbred Strains; Stomach; Vincristine; Wound Healing | 1981 |
[Initial results in allo- and auto-bone marrow transplantation in acute leukemia in East Germany].
Topics: Acute Disease; Adolescent; Adult; Body Weight; Bone Marrow Transplantation; Combined Modality Therapy; Cyclophosphamide; Cystitis; Cytarabine; Drug Therapy, Combination; Female; Germany, East; Humans; Leukemia; Male; Methotrexate; Mycoses; Stomatitis; Transplantation, Autologous; Transplantation, Homologous; Vincristine; Whole-Body Irradiation | 1984 |
Effect of the antineoplastic agent methotrexate on experimental heterotopic new bone formation in rats.
Topics: Animals; Body Weight; Bone and Bones; Bone Development; Bone Transplantation; Calcium; Kinetics; Male; Methotrexate; Rats; Rats, Inbred Strains | 1984 |
Effect of nutritional status on the hepatobiliary excretion of methotrexate in the rat.
Topics: Animals; Bile; Body Weight; Kinetics; Liver; Male; Methotrexate; Nutritional Physiological Phenomena; Organ Size; Protein-Energy Malnutrition; Rats; Rats, Inbred Strains | 1983 |
Effects of nutritional depletion and repletion on plasma methotrexate pharmacokinetics.
Topics: Animals; Body Weight; Carcinoma 256, Walker; Half-Life; Kinetics; Male; Methotrexate; Nutrition Disorders; Protein Deficiency; Rats; Rats, Inbred Strains | 1984 |
Pharmacokinetics of methotrexate in adult Indian patients and its relationship to nutritional status.
Topics: Adult; Anthropometry; Biotransformation; Body Weight; Diet; Half-Life; Head and Neck Neoplasms; Humans; India; Kinetics; Methotrexate; Models, Biological; Nutritional Requirements; White People | 1984 |
Effects of nutritional repletion on host and tumor response to chemotherapy.
Topics: Animals; Body Weight; Carcinoma 256, Walker; Dietary Proteins; Energy Intake; Food Deprivation; Injections, Intravenous; Male; Methotrexate; Protein-Energy Malnutrition; Rats; Time Factors | 1980 |
Effects of enteral and parenteral nutrition on tumor response to chemotherapy in experimental animals.
Topics: Administration, Oral; Animals; Body Weight; Carcinoma 256, Walker; Diet; Dose-Response Relationship, Drug; Methotrexate; Parenteral Nutrition; Rats | 1981 |
Microsomal metabolism of antipyrine in rats treated with antineoplastic drugs.
Topics: Animals; Antineoplastic Agents; Antipyrine; Body Weight; Cyclophosphamide; Fluorouracil; Kinetics; Male; Methotrexate; Microsomes, Liver; Organ Size; Rats; Rats, Inbred Strains | 1983 |
Adjuvant chemotherapy (CMF) for breast carcinoma: hematological side effects.
Topics: Antineoplastic Combined Chemotherapy Protocols; Body Weight; Breast Neoplasms; Carcinoma; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leukopenia; Mastectomy; Methotrexate; Nausea; Neoplasm Staging; Platelet Count; Time Factors; Vomiting | 1982 |
5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental | 1981 |
Increased survival of cancer-bearing mice treated with inhibitors of prostaglandin synthesis alone or with chemotherapy.
Topics: Adenocarcinoma; Animals; Biological Availability; Body Weight; Drug Therapy, Combination; Female; Flurbiprofen; Indomethacin; Male; Mammary Neoplasms, Experimental; Melphalan; Methotrexate; Mice; Neoplasm Recurrence, Local; Propionates; Prostaglandin Antagonists | 1982 |
Trauma-induced glial proliferation: possible involvement of the immune system.
Topics: Animals; Antibody Formation; Body Weight; Brain Injuries; Cell Division; Hydrocortisone; Immunosuppressive Agents; Male; Methotrexate; Neuroglia; Rats; Rats, Inbred Strains | 1982 |
[Effects of immunosuppressive drugs on the fetal-placental unit].
Topics: Animals; Body Weight; Female; Fetal Death; Fetal Resorption; Fluorouracil; Immunosuppressive Agents; Methotrexate; Organ Size; Placenta; Pregnancy; Rats | 1980 |
Nutritional effects of surgery, radiation therapy, and adjuvant chemotherapy for soft tissue sarcomas.
Topics: Adolescent; Adult; Blood Proteins; Body Weight; Cachexia; Cyclophosphamide; Doxorubicin; Female; Humans; Leukocyte Count; Lymphocytes; Male; Methotrexate; Middle Aged; Sarcoma; Serum Albumin; Soft Tissue Neoplasms | 1981 |
Androgen stimulated chemotherapy in the Dunning R-3327 prostatic adenocarcinoma.
Topics: Adenocarcinoma; Androgens; Animals; Body Weight; Castration; Cell Cycle; Male; Methotrexate; Neoplasms, Experimental; Prostatic Neoplasms; Rats; Testosterone; Time Factors | 1981 |
Tumor growth in experimental animals: nutritional manipulation and chemotherapeutic response in the rat.
Topics: Animals; Body Weight; Carcinoma 256, Walker; Dietary Carbohydrates; Dietary Proteins; Male; Methotrexate; Rats | 1980 |
Response of the rat small-intestine epithelium to methotrexate.
Topics: Animals; Appetite; Biological Transport; Body Weight; Epithelial Cells; Epithelium; Jejunum; Male; Methotrexate; Mitosis; Rats; Sodium | 1980 |
Effects of naproxen and methotrexate on the extent of aortic lesions and cholesterol concentrations in cholesterol-fed rabbits.
Topics: Animals; Aorta; Arteriosclerosis; Body Weight; Cell Division; Cholesterol; Diet, Atherogenic; Male; Methotrexate; Naproxen; Rabbits | 1980 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
Topics: Animals; Body Weight; Doxorubicin; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Leukocyte Count; Male; Mammary Neoplasms, Experimental; Methotrexate; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1980 |
Metallothionein and zinc homeostasis during tumor progression. Effect of methotrexate treatment.
Topics: Adenocarcinoma; Animals; Blood Glucose; Body Weight; Calcium; Female; Homeostasis; Liver; Mammary Neoplasms, Experimental; Metallothionein; Methotrexate; Neoplasm Transplantation; Organ Size; Rats; Zinc | 1994 |
Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Division; Female; Fluorodeoxyuridylate; Fluorouracil; Humans; Leucovorin; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Tumor Cells, Cultured | 1995 |
Radiation effects on growth are altered in rats by prednisone and methotrexate.
Topics: Animals; Behavior, Animal; Body Weight; Cephalometry; Cranial Irradiation; Drug Therapy, Combination; Female; Growth Disorders; Male; Methotrexate; Prednisolone; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Skull; Specific Pathogen-Free Organisms | 1994 |
Methotrexate alters carbon flow through the hepatic folate-dependent one-carbon pool in rats.
Topics: Animals; Body Weight; Carbon; Carbon Radioisotopes; Folic Acid; Histidine; Liver; Male; Methotrexate; Rats; Rats, Sprague-Dawley | 1996 |
Effect of zinc deficiency on chromosomal abnormalities in mice.
Topics: Animals; Body Weight; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosome Disorders; Diet; Diploidy; Feeding Behavior; Female; Male; Methotrexate; Mice; Mitotic Index; Zinc | 1996 |
Evaluation of cardiac subacute toxicity of epirubicin, chlorambucil, cisplatin, methotrexate and a homo-aza-steroid ester with antitumor activity in rats using serum biochemical parameters.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Aspartate Aminotransferases; Body Weight; Chlorambucil; Cisplatin; Creatine Kinase; Epirubicin; Heart Diseases; Isoenzymes; L-Lactate Dehydrogenase; Methotrexate; Rats | 1997 |
Vitamin A deficiency exacerbates methotrexate-induced jejunal injury in rats.
Topics: Administration, Oral; alpha-Glucosidases; Animals; Antimetabolites, Antineoplastic; Avitaminosis; Body Weight; Diarrhea; Disaccharides; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Food, Fortified; Incidence; Intestinal Mucosa; Jejunal Diseases; Jejunum; Liver; Male; Methotrexate; Rats; Rats, Wistar; Sucrase; Vitamin A | 1997 |
Short-term low dose methotrexate ameliorates abnormal bone metabolism and bone loss in adjuvant induced arthritis.
Topics: Animals; Arthritis, Experimental; Body Weight; Bone Density; Bone Remodeling; Cells, Cultured; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Female; Methotrexate; Osteocalcin; Osteoclasts; Rats; Rats, Inbred Lew | 1997 |
Evaluation of damaged small intestine of mouse following methotrexate administration.
Topics: Administration, Oral; Animals; Anticoagulants; Antimetabolites, Antineoplastic; Body Weight; Dextrans; Intestinal Absorption; Intestine, Small; Male; Methotrexate; Mice; Permeability | 1998 |
A soy-derived antiapoptotic fraction decreases methotrexate toxicity in the gastrointestinal tract of the rat.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Apoptosis; Biological Assay; Body Weight; Diarrhea; Dose-Response Relationship, Drug; Eating; Folic Acid Antagonists; Incidence; Male; Methotrexate; Nucleic Acid Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Soybean Proteins; Time Factors | 1997 |
Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Dextrans; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Fluorescein-5-isothiocyanate; Intestinal Absorption; Intestinal Diseases; Intestine, Small; Male; Methotrexate; Mice; Vitamin A | 1998 |
Methotrexate therapy for pediatric patients with inflammatory bowel disease.
Topics: Adolescent; Anti-Inflammatory Agents; Body Weight; Child; Humans; Inflammatory Bowel Diseases; Methotrexate | 1998 |
Induction of cytogenetic damage in human lymphocytes in vitro and of antineoplastic effects in Ehrlich ascites tumor cells in vivo treated by methotrexate, hyperthermia and/or caffeine.
Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Body Weight; Caffeine; Carcinoma, Ehrlich Tumor; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Fever; Humans; Lymphocytes; Male; Methotrexate; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Sister Chromatid Exchange; Survival Rate | 1998 |
Preventive effects of germinated barley foodstuff on methotrexate-induced enteritis in rats.
Topics: Animals; Body Weight; Diarrhea; Dietary Fiber; DNA; Eating; Enteritis; Germination; Hordeum; Intestinal Mucosa; Male; Methotrexate; Peroxidase; Proteins; Rats; Rats, Sprague-Dawley; RNA; Sucrase | 1998 |
A one-month repeated oral dose toxicity study of methotrexate in unilaterally nephrectomized rats.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Body Weight; Bone Marrow; Dose-Response Relationship, Drug; Eating; Female; Glomerular Filtration Rate; Liver; Lung; Male; Methotrexate; Nephrectomy; No-Observed-Adverse-Effect Level; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Age-depending effects of methotrexate treatment on systemic bone turnover in experimental adjuvant arthritis.
Topics: Absorptiometry, Photon; Aging; Animals; Arthritis, Experimental; Biomarkers; Body Weight; Bone and Bones; Bone Density; Bone Regeneration; Foot; Immunosuppressive Agents; Male; Methotrexate; Organ Size; Rats; Rats, Sprague-Dawley | 1999 |
Methotrexate-albumin conjugate causes tumor growth delay in Dunning R3327 HI prostate cancer-bearing rats.
Topics: Animals; Body Weight; Cell Division; Cell Line; Drug Carriers; Drug Resistance, Neoplasm; Humans; Lysosomes; Male; Methotrexate; Mice; Mice, Nude; Prostatic Neoplasms; Rats; Serum Albumin; Tissue Distribution; Transplantation, Heterologous | 1999 |
The effect of tryptophan plus methionine, 5-azacytidine, and methotrexate on adjuvant arthritis of rat.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Azacitidine; Body Weight; Drug Therapy, Combination; Freund's Adjuvant; Male; Methionine; Methotrexate; Rats; Tryptophan | 1999 |
Protective effect of aged garlic extract on the small intestinal damage of rats induced by methotrexate administration.
Topics: Animals; Body Weight; Garlic; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar | 1999 |
Bone mass change during methotrexate treatment in patients with juvenile rheumatoid arthritis.
Topics: Adolescent; Analysis of Variance; Antirheumatic Agents; Arthritis, Juvenile; Blood Sedimentation; Body Weight; Bone Density; Case-Control Studies; Child; Child, Preschool; Female; Humans; Infant; Longitudinal Studies; Male; Methotrexate; Puberty; Regression Analysis; Spine | 1999 |
Effects of methotrexate and cyclophosphamide on polyamine levels in various tissues of rats.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Biogenic Polyamines; Body Weight; Buffers; Cell Cycle; Chromatography, High Pressure Liquid; Cyclophosphamide; Male; Methotrexate; Organ Size; Rats; Rats, Sprague-Dawley | 1999 |
Central action of some cytostatics--methotrexate (MTX) and doxorubicin (DXR). I. Long-term influence on the pain sensitivity and activity of brain dopaminergic system in mice.
Topics: Analgesics; Animals; Behavior, Animal; Body Weight; Brain; Catalepsy; Doxorubicin; Drug Interactions; Exploratory Behavior; Female; Haloperidol; Locomotion; Male; Methotrexate; Mice; Norepinephrine; Pain | 1998 |
Additive effect of indomethacin and methotrexate on suppression of growth in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Drinking; Drug Interactions; Eating; Folic Acid Antagonists; Growth; Indomethacin; Male; Methotrexate; Organ Size; Rats; Rats, Sprague-Dawley; Tetrahydrofolate Dehydrogenase | 1999 |
The consequence of p53 overexpression for liver tumor development and the response of transformed murine hepatocytes to genotoxic agents.
Topics: Animals; Antigens, Polyomavirus Transforming; Apoptosis; bcl-2-Associated X Protein; Binding Sites; Body Weight; Cell Line, Transformed; Crosses, Genetic; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Disease Progression; DNA; DNA Damage; Doxorubicin; Gamma Rays; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, p53; Genotype; Hyperplasia; Liver; Liver Diseases; Liver Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Nuclear Proteins; Organ Size; Precancerous Conditions; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Simian virus 40; Tumor Suppressor Protein p53; Ultraviolet Rays | 2000 |
Effect of single chemotherapeutic agents on the growing skeleton of the rat.
Topics: Animals; Antineoplastic Agents; Body Weight; Bone Development; Cisplatin; Doxorubicin; Kidney; Liver; Male; Methotrexate; Muscle Development; Muscle, Skeletal; Rats; Rats, Wistar; Tibia | 2000 |
A preclinical model for experimental chemotherapy of human head and neck cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Body Weight; Carboplatin; Carcinoma, Squamous Cell; Cisplatin; Disease Models, Animal; Docetaxel; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Ifosfamide; Methotrexate; Mice; Mice, Nude; Paclitaxel; Survival Rate; Taxoids | 2001 |
MTX affects inflammation and tissue destruction differently in the rat AA model.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Joints; Methotrexate; Rats; Rats, Inbred Lew | 2001 |
Effects of growth hormone plus a hyperproteic diet on methotrexate-induced injury in rat intestines.
Topics: Animals; Apoptosis; Atrophy; Bacterial Translocation; Body Weight; Cell Division; Dietary Proteins; Drug Evaluation; Human Growth Hormone; Insulin-Like Growth Factor I; Intestinal Diseases; Intestinal Mucosa; Ki-67 Antigen; Malabsorption Syndromes; Male; Methotrexate; Rats; Rats, Wistar; Recombinant Proteins; Somatostatin; Somatostatin-28 | 2001 |
Folinic acid protects against suppression of growth by methotrexate in mice.
Topics: Animals; Antidotes; Body Weight; Eating; Folic Acid Antagonists; Growth Disorders; Intestine, Small; Kidney; Leucovorin; Liver; Male; Methotrexate; Mice; Mice, Inbred BALB C; Tetrahydrofolate Dehydrogenase | 2001 |
Weekly pulse therapy of methotrexate improves survival compared with its daily administration in MRL/lpr mice.
Topics: Animals; Antirheumatic Agents; Autoantibodies; Autoimmunity; Blood Cell Count; Body Weight; Glomerulonephritis; Kidney Function Tests; Lupus Erythematosus, Systemic; Lymphatic Diseases; Male; Methotrexate; Mice; Mice, Inbred MRL lpr; Proteinuria; Radiography; Survival Analysis; Urea | 2002 |
Tolerance of long-term methotrexate infusions by mice.
Topics: Animals; Body Weight; DNA; Drug Tolerance; Hydrogen-Ion Concentration; Male; Methotrexate; Mice; Mice, Inbred Strains; Proteins; Tetrahydrofolate Dehydrogenase | 1976 |
[Parenteral feeding during aggressive chemotherapy of various neoplasms].
Topics: Adult; Bleomycin; Body Weight; Cachexia; Cyclophosphamide; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasms; Parenteral Nutrition; Vincristine | 1978 |
Vincristine-methotrexate combination chemotherapy and the influence of weight loss on experimental tumour growth.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Osteosarcoma; Sarcoma, Experimental; Starvation; Vincristine | 1979 |
Potentiation of methotrexate embryolethality by aspirin in rats.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Body Weight; Drug Synergism; Embryo, Mammalian; Female; Fetal Death; Methotrexate; Pregnancy; Rats; Tissue Distribution | 1978 |
Neuropharmacological effects of methotrexate perfused through the cerebrospinal fluid system of the rhesus monkey.
Topics: Animals; Avoidance Learning; Behavior, Animal; Body Weight; Brain; Central Nervous System; Cerebrospinal Fluid; Discrimination, Psychological; Eating; Female; Haplorhini; Inulin; Macaca; Male; Methotrexate; Motor Activity; Seizures | 1976 |
Effects of varying the interval between courses of methotrexate on its myelotoxic and anti-leukaemic activities.
Topics: Animals; Body Weight; Bone Marrow Cells; Cell Count; Dose-Response Relationship, Drug; Leukemia, Experimental; Leukocyte Count; Methotrexate; Neoplasm Transplantation; Neutropenia; Neutrophils; Rats; Time Factors; Transplantation, Isogeneic | 1977 |
Hepatotoxicity in Wistar rats following chronic methotrexate administration: a model of human reaction.
Topics: Age Factors; Animals; Body Weight; Bone Marrow; Digestive System; Fatty Liver; Humans; Liver; Lung; Lymphocytes; Male; Methotrexate; Necrosis; Rats; Skin; Spleen; Testis; Triglycerides | 1977 |
Effects of methotrexate and phenobarbital on the hepatic microsomal drug-metabolizing enzymes in normal rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Body Weight; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Ethylmorphine-N-Demethylase; Liver; Male; Methotrexate; Microsomes, Liver; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Proteins; Rats | 1975 |
Effects of amethopterin (methotrexate) on the evolution of pregnancy in rats.
Topics: Abortifacient Agents; Animals; Body Weight; Female; Fetal Death; Fetus; Gestational Age; Hypertrophy; Lethal Dose 50; Methotrexate; Organ Size; Placenta; Pregnancy; Pregnancy, Animal; Rats | 1975 |
Toxoplasma gondii: disease patterns in mice treated with the folate antagonist methotrexate.
Topics: Animals; Ascitic Fluid; Body Weight; Brain; Female; Methotrexate; Mice; Mice, Inbred Strains; Time Factors; Toxoplasmosis | 1976 |
Liver biopsies from psoriatics related to methotrexate therapy. 1. Findings in 123 consecutive non-methotrexate treated patients.
Topics: Adult; Age Factors; Aged; Alcohol Drinking; Aspartate Aminotransferases; Body Weight; Female; Humans; Liver; Liver Cirrhosis; Liver Diseases; Male; Methotrexate; Middle Aged; Obesity; Psoriasis | 1976 |
Cytotoxic analog of somatostatin containing methotrexate inhibits growth of MIA PaCa-2 human pancreatic cancer xenografts in nude mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Division; Cell Line; Growth Hormone; Humans; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Octreotide; Organ Size; Pancreatic Neoplasms; Receptors, Neurotransmitter; Receptors, Somatostatin | 1992 |
Effect of luteinizing hormone-releasing hormone analogs containing cytotoxic radicals on growth of estrogen-independent MXT mouse mammary carcinoma in vivo.
Topics: Amino Acid Sequence; Animals; Anthraquinones; Binding Sites; Body Weight; Cell Division; Female; Gonadotropin-Releasing Hormone; Growth Hormone; Kinetics; Luteinizing Hormone; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred Strains; Molecular Sequence Data; Ovary; Receptors, LH; Triptorelin Pamoate; Uterus | 1992 |
Effect of supplemental dietary glutamine on methotrexate concentrations in tumors.
Topics: Animals; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Energy Intake; Glutamine; Humans; Male; Methotrexate; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1992 |
Methotrexate treatment of severe asthma in children.
Topics: Adolescent; Albuterol; Asthma; Beclomethasone; Body Height; Body Weight; Child; Child, Preschool; Cromolyn Sodium; Female; Forced Expiratory Volume; Humans; Male; Maximal Expiratory Flow Rate; Methotrexate; Prednisone; Spirometry; Theophylline; Vital Capacity | 1992 |
Growth and development of children of mothers treated with chemotherapy during pregnancy: current status of 43 children.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Behavior; Bleomycin; Body Height; Body Weight; Child; Child Development; Child, Preschool; Dacarbazine; Doxorubicin; Female; Follow-Up Studies; Hodgkin Disease; Humans; Immunoglobulins; Intelligence; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, Non-Hodgkin; Mechlorethamine; Methotrexate; Prednisone; Pregnancy; Pregnancy Complications, Neoplastic; Procarbazine; Sex Characteristics; Vinblastine; Vincristine | 1991 |
Studies on the changes in plasma lipids and lipoproteins in CMF treated breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Body Weight; Breast Neoplasms; Cholesterol; Cisplatin; Fatty Acids; Female; Fluorouracil; Humans; Lipids; Lipoproteins; Menopause; Methotrexate; Phospholipids; Triglycerides | 1991 |
A longitudinal study of growth and growth hormone secretion in children during treatment for acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Body Height; Body Weight; Child; Child, Preschool; Combined Modality Therapy; Dexamethasone; Female; Glucocorticoids; Growth; Growth Hormone; Humans; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiotherapy Dosage; Vincristine | 1991 |
Treatment complications after sequential combination chemotherapy and radiotherapy with or without surgery in previously untreated squamous cell carcinoma of the head and neck.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Body Weight; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Hypothyroidism; Leucovorin; Male; Methotrexate; Mucous Membrane; Osteoradionecrosis; Pneumonia; Radiotherapy; Time Factors; Ulcer | 1985 |
Nutritional and immunological investigations in head and neck cancer patients before and after therapy.
Topics: Adult; Aged; Bleomycin; Blood Proteins; Body Weight; Cholinesterases; Cisplatin; Head and Neck Neoplasms; Humans; Leukocyte Count; Lymphocytes; Methotrexate; Middle Aged; Nutritional Physiological Phenomena; Prognosis; Retinol-Binding Proteins; Skin Tests; Time Factors; Vitamin A | 1985 |
Interaction of 5'-deoxy-5-fluorouridine and methotrexate. A basis for reduced methotrexate toxicity.
Topics: Animals; Blood Cell Count; Body Weight; Floxuridine; Ileal Diseases; Ileum; Male; Methotrexate; Mice | 1989 |
[Effect of anticancer agents on rat prostate. Evaluation of organ weight, histological finding and 5 alpha-reductase activities].
Topics: Animals; Antineoplastic Agents; Bleomycin; Body Weight; Cholestenone 5 alpha-Reductase; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Male; Mechlorethamine; Methotrexate; Organ Size; Oxidoreductases; Peplomycin; Prostate; Rats; Vinblastine; Vincristine | 1985 |
The effect of methotrexate on the development of synapses in the neonatal rat hippocampus.
Topics: Animals; Animals, Newborn; Body Weight; Female; Hippocampus; Male; Methotrexate; Rats; Rats, Inbred Strains; Synapses | 1989 |
[The prevention of the side effects of cytostatics by administering them at various times of day].
Topics: Animals; Body Temperature; Body Weight; Circadian Rhythm; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Transplantation; Rats; Time Factors | 1989 |
Lack of correlation between nucleated bone marrow cell dose, marrow CFU-GM dose or marrow CFU-E dose and the rate of HLA-identical sibling marrow engraftment.
Topics: Body Weight; Bone Marrow Transplantation; Cell Count; Cyclosporins; Hematopoietic Stem Cell Transplantation; HLA Antigens; Humans; Immunosuppression Therapy; Leukemia; Methotrexate; Whole-Body Irradiation | 1985 |
Long-term effects of intravenous hyperalimentation administered during intensive chemotherapy for small cell bronchogenic carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Hypersensitivity, Delayed; Ifosfamide; Lung Neoplasms; Male; Methotrexate; Middle Aged; Parenteral Nutrition, Total; Procarbazine; Prognosis; Vincristine | 1987 |
Reduction of methotrexate toxicity with improved nutritional status in tumor-bearing animals.
Topics: Adenocarcinoma; Animals; Body Weight; Dietary Proteins; Enteral Nutrition; Female; Leucovorin; Methotrexate; Protein Deficiency; Rats; Rats, Inbred Lew; Rats, Inbred Strains | 1988 |
Histochemical changes in the composition of mucins in goblet cells during methotrexate-induced mucosal atrophy in rats.
Topics: Animals; Atrophy; Body Weight; Eating; Epithelium; Female; Intestinal Mucosa; Jejunum; Methotrexate; Mitosis; Mucins; Rats; Sialomucins; Time Factors | 1988 |
Weight gain in women with localized breast cancer--a descriptive study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Humans; Mastectomy; Methotrexate; Middle Aged; Ovariectomy; Prednisone; Prognosis; Retrospective Studies; Time Factors | 1988 |
Systemic resistance to methotrexate in transgenic mice carrying a mutant dihydrofolate reductase gene.
Topics: Animals; Body Weight; Digestive System; Drug Resistance; Erythrocyte Count; Genetic Engineering; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Transfection | 1986 |
Evaluation of some prognostic factors for advanced multicentric lymphosarcoma in the dog: 147 cases (1978-1981).
Topics: Age Factors; Animals; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Weight; Cyclophosphamide; Dog Diseases; Dogs; Female; Lymphoma, Non-Hodgkin; Male; Methotrexate; Prognosis; Retrospective Studies; Sex Factors; Vincristine | 1987 |
Methotrexate effects on heterotopic bone in rats.
Topics: Animals; Body Weight; Bone and Bones; Calcium; Male; Methotrexate; Osteogenesis; Rats; Rats, Inbred Strains | 1987 |
Long-term survivors in metastatic non-small-cell lung cancer: an Eastern Cooperative Oncology Group Study.
Topics: Adenocarcinoma; Aged; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Neoplasm Metastasis; Procarbazine; Progesterone; Prognosis; Serum Albumin; Vinblastine | 1986 |
Alteration of chemotherapy toxicity using a chemically defined liquid diet in rats.
Topics: Animals; Bacteria; Body Weight; Energy Intake; Food, Formulated; Intestine, Small; Male; Methotrexate; Rats; Rats, Inbred F344; Sepsis | 1986 |
Modulation of high-dose methotrexate toxicity by a non-toxic level of 5-fluorouracil.
Topics: Animals; Body Weight; Erythrocyte Count; Fluorouracil; Hematocrit; Hemoglobins; Leukocyte Count; Leukopenia; Male; Methotrexate; Mice; Platelet Count; Time Factors | 1986 |
Physical and psychologic distress associated with adjuvant chemotherapy in women with breast cancer.
Topics: Activities of Daily Living; Adult; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Humans; Mastectomy; Methotrexate; Middle Aged; Postoperative Care; Prednisone; Psychiatric Status Rating Scales; Sexual Behavior; Stress, Psychological; Time Factors; Vincristine | 1986 |
In vivo synergy of vitamin K3 and methotrexate in tumor-bearing animals.
Topics: Animals; Body Weight; Carcinoma 256, Walker; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Methotrexate; Rats; Vitamin K; Vitamin K 3 | 1986 |
Megestrol acetate therapy for advanced breast cancer.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Evaluation; Female; Fluorouracil; Humans; Male; Megestrol; Megestrol Acetate; Menopause; Methotrexate; Receptors, Estrogen; Receptors, Progesterone | 1985 |
Weight gain in patients receiving adjuvant chemotherapy for carcinoma of the breast.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Humans; Lymphatic Metastasis; Mastectomy; Methotrexate; Middle Aged; Neoplasm Staging; Prednisone; Receptors, Estrogen; Vincristine | 1985 |
Unexpectedly severe toxicity from intensive early treatment of childhood lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Candidiasis; Child; Child, Preschool; Female; Gastrointestinal Diseases; Hospitalization; Humans; Infant; Leukemia, Lymphoid; Male; Methotrexate; Parenteral Nutrition, Total | 1985 |
Enhanced tumor response to cycle-specific chemotherapy by pulse total parenteral nutrition.
Topics: Adenocarcinoma; Animals; Body Composition; Body Weight; Energy Intake; Female; Leukocyte Count; Mammary Neoplasms, Experimental; Methotrexate; Nitrogen; Parenteral Nutrition; Parenteral Nutrition, Total; Random Allocation; Rats; Rats, Inbred Strains | 1985 |
[The effect of cis-platinum (CDDP) on methotrexate-resistant choriocarcinoma cell line].
Topics: Animals; Body Weight; Cell Division; Cell Line; Choriocarcinoma; Cisplatin; Dactinomycin; Drug Resistance; Female; Humans; Methotrexate; Mice; Mice, Nude; Pregnancy; Uterine Neoplasms | 1986 |
Potentiation of methotrexate-induced gastrointestinal toxicity by non-steroidal anti-inflammatory drugs (NSAIDs) and vincristine.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Drug Synergism; Glucose; In Vitro Techniques; Intestinal Absorption; Male; Methotrexate; Mice; Tyrosine; Vincristine | 1985 |
Weight gain during adjuvant chemotherapy for breast cancer.
Topics: Adult; Aged; Body Weight; Breast Neoplasms; Cyclophosphamide; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Prednisone; Prognosis; Risk | 1985 |
Effects of methotrexate on intestinal transit in rats.
Topics: Animals; Body Weight; Chromium Radioisotopes; Gastrointestinal Motility; Male; Methotrexate; Rats; Rats, Inbred Strains | 1985 |
Combination chemotherapy of sarcoma 180 with methotrexate and bleomycin.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Body Weight; Female; Methotrexate; Mice; Mice, Inbred Strains; Sarcoma 180; Time Factors | 1973 |
Effects of the immunosuppressant methotrexate in ponies.
Topics: Animals; Benzyl Compounds; Body Temperature; Body Weight; Ephedrine; Erythrocyte Count; Ethylenediamines; Gastrointestinal Diseases; Hematocrit; Histamine H1 Antagonists; Horse Diseases; Horses; Immunosuppression Therapy; Injections, Intramuscular; Leukocyte Count; Methotrexate; Pyridines; Strongyle Infections, Equine | 1973 |
Effectiveness and toxicity of immunosuppressive agents: inhibition of the rat popliteal node graft-vs.-host reaction.
Topics: Animals; Asparaginase; Body Weight; Dose-Response Relationship, Drug; Female; Graft vs Host Reaction; Immunosuppressive Agents; Indomethacin; Lymph Nodes; Male; Medroxyprogesterone; Methotrexate; Methylprednisolone; Rats; Rats, Inbred Strains; Rifampin; Skin Transplantation; T-Lymphocytes; Transplantation, Homologous | 1974 |
The variability of individual tolerance to methotrexate in cancer patients.
Topics: Adult; Age Factors; Aged; Alopecia; Blood Urea Nitrogen; Body Weight; Chemical and Drug Induced Liver Injury; Conjunctivitis; Creatinine; Diarrhea; Drug Eruptions; Folic Acid; Humans; Injections, Intravenous; Leukopenia; Methotrexate; Middle Aged; Nausea; Neoplasms; Serum Albumin; Stomatitis; Thrombocytopenia; Time Factors; Vomiting | 1971 |
Treatment of advanced carcinoma of the cervix with adriamycin and methotrexate combined.
Topics: Adult; Alopecia; Anxiety; Body Weight; Bone Marrow; Carcinoma; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Methotrexate; Middle Aged; Mouth Diseases; Nausea; Neoplasm Metastasis; Remission, Spontaneous; Taste; Thrombophlebitis; Uterine Cervical Neoplasms | 1974 |
Determination of endotoxicity in bacterial vaccines.
Topics: Acetone; Animals; Bacterial Vaccines; Body Weight; Cyclophosphamide; Dactinomycin; Drug Synergism; Escherichia coli; Fluorouracil; Hot Temperature; Injections, Intraperitoneal; Lethal Dose 50; Lipopolysaccharides; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred BALB C; Mitomycins; Pertussis Vaccine; Polysaccharides, Bacterial; Pseudomonas aeruginosa; Salmonella typhi; Species Specificity; Typhoid-Paratyphoid Vaccines; Vaccines, Attenuated | 1973 |
Antagonism between inhibitors of DNA synthesis.
Topics: Animals; Body Weight; Cytarabine; Drug Combinations; Leukemia; Male; Meninges; Methotrexate; Mice; Mice, Inbred CBA; Rats; Rats, Inbred Strains | 1972 |
Animal scale-up.
Topics: Animals; Biological Transport; Biotransformation; Body Weight; Chlorides; Cytarabine; Dialysis; Diffusion; Humans; Kinetics; Mammals; Methotrexate; Models, Biological; Organ Specificity; Pharmaceutical Preparations; Pharmacology; Species Specificity; Thermodynamics; Thiopental; Time Factors | 1973 |
Combination chemotherapy in lymphosarcoma and reticulum cell sarcoma.
Topics: Adolescent; Adult; Aged; Body Weight; Cyclophosphamide; Drug Synergism; Hemoglobinometry; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Prednisone; Vincristine | 1969 |
Intrathecal chemotherapy. Selection of cytostatic agents.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Body Weight; Brain Neoplasms; Cyclophosphamide; Humans; Injections, Spinal; Methotrexate; Mitomycins; Nitrogen Mustard Compounds; Rabbits; Rats; Sarcoma, Yoshida; Thiotepa; Vincristine | 1970 |
Toxicologic studies of the 2,4-diamino-quinazoline antifolate, methasquin (NSC-122870).
Topics: Administration, Oral; Animals; Blood Cells; Body Weight; Bone Marrow; Bone Marrow Cells; Dogs; Female; Folic Acid Antagonists; Haplorhini; Injections, Intraperitoneal; Injections, Intravenous; Intestines; Macaca; Male; Methotrexate; Mice; Quinazolines; Rats | 1971 |
Interspecies correlation of plasma concentration history of methotrexate (NSC-740).
Topics: Animals; Body Weight; Dogs; Female; Half-Life; Haplorhini; Humans; Kinetics; Male; Methotrexate; Mice; Rats; Species Specificity; Thermodynamics | 1970 |
Glucose oxidation in isoproterenol-stimulated salivary glands of the rat.
Topics: Animals; Body Weight; Carbon Dioxide; Carbon Isotopes; Diaphragm; Glucose; Glycolysis; In Vitro Techniques; Isoproterenol; Kidney; Liver; Male; Methotrexate; Organ Size; Pentosephosphates; Rats; Stimulation, Chemical; Submandibular Gland | 1972 |
Studies on inhibition of viral oncogenesis. 3. Effect of clam extracts and methotrexate on tumor formation in male and female hamsters induced by virulent and attenuated adenovirus-12.
Topics: Adenoviridae; Animals; Animals, Newborn; Antineoplastic Agents; Bivalvia; Body Weight; Cricetinae; Female; Injections, Subcutaneous; Liver Extracts; Male; Methotrexate; Neoplasms, Experimental; Organotherapy; Sex Factors; Time Factors; Virulence | 1972 |
Effects of nitrogen mustard, methotrexate and hydrocortisone on cell replication in rat ileum and spleen.
Topics: Anemia; Animals; Autoradiography; Blood Cell Count; Body Weight; DNA; DNA Replication; Hydrocortisone; Ileum; Leukopenia; Lymphocytes; Male; Methotrexate; Mitosis; Nitrogen Mustard Compounds; Rats; Rats, Inbred Strains; Spleen; Thymidine; Tritium | 1972 |
Adjuvant-induced arthritis in rats. II. Drug effects on physiologic, biochemical and immunologic parameters.
Topics: Animals; Anti-Inflammatory Agents; Antibodies; Arthritis; Aspirin; Body Weight; Cyclophosphamide; Disease Models, Animal; Freund's Adjuvant; Hindlimb; Immunosuppressive Agents; Indomethacin; Male; Methotrexate; Muramidase; Phenylbutazone; Prednisolone; Rats | 1971 |
Induction and characteristics of resistance to L-asparaginase (NSC-109229) in mouse leukemia L5178Y.
Topics: Amino Acids; Animals; Asparaginase; Azaserine; Body Weight; Cytarabine; Drug Resistance; Female; Leukemia, Experimental; Male; Methotrexate; Mice; Neoplasm Transplantation; Time Factors | 1971 |
The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.
Topics: Animals; Body Weight; Depression, Chemical; DNA; Epithelial Cells; Folic Acid Antagonists; Intestinal Mucosa; Intestine, Small; Lethal Dose 50; Liver; Male; Methotrexate; Mice; Mitosis; Organ Size; Phosphates; Phosphorus Isotopes; Thymidine; Tritium; Uridine | 1971 |
Methotrexate pharmacokinetics.
Topics: Administration, Oral; Animals; Body Weight; Dogs; Humans; Injections, Intravenous; Intestinal Absorption; Kidney; Kinetics; Liver; Methotrexate; Mice; Models, Biological; Muscles; Rats; Time Factors | 1971 |
Quinazoline antifolates: dosage schedules and toxicity.
Topics: Aminopterin; Animals; Antineoplastic Agents; Body Weight; Dosage Forms; Folic Acid Antagonists; Leucovorin; Leukemia, Experimental; Male; Methotrexate; Mice; Quinazolines | 1971 |
Growth effects of long-term antileukemic therapy.
Topics: Adolescent; Adrenal Cortex Hormones; Body Height; Body Weight; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Leukemia; Male; Mercaptopurine; Methotrexate; Prednisone; Vincristine | 1969 |
Chemotherapy of experimental allergic encephalomyelitis (EAE).
Topics: Allopurinol; Aminocaproates; Analgesics; Animals; Antineoplastic Agents; Azathioprine; Body Weight; Chloroquine; Colchicine; Cortisone; Cyclophosphamide; Cyproheptadine; Diazoxide; Dimethyl Sulfoxide; Encephalomyelitis, Autoimmune, Experimental; Hydrocortisone; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Methyldopa; Nialamide; Oils; Organ Size; Rats; Strychnine; Talc; Thalidomide; Thioguanine; Thiomalates | 1969 |
Treatment of experimental mouse hemoblastosis. VII. Time course of change in the frequency of mitoses of leukaemic leukocytes (L 14 AKR and LaH VUFB) after administration of methotrexate.
Topics: Animals; Body Weight; Leukemia, Experimental; Leukocytes; Liver; Methotrexate; Mice; Mitosis; Organ Size; Spleen; Time Factors | 1970 |
Immune response to insulin in guinea pigs.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Azathioprine; Body Weight; Cattle; Chromatography; Cyclophosphamide; Drug Hypersensitivity; Guinea Pigs; Immunization; Immunoassay; Immunoglobulin G; Immunosuppressive Agents; Insulin; Insulin Antibodies; Insulin, Long-Acting; Male; Mercaptopurine; Methotrexate; Oils; Prednisolone; Protein Binding; Swine | 1971 |
Principles of concentration of antitumour and immunodepressive chemotherapeutic agents in the lymphatic system.
Topics: Animals; Body Weight; Injections, Intraperitoneal; Leukocyte Count; Lymph Nodes; Lymphocytes; Macromolecular Substances; Methotrexate; Mice; Spleen | 1968 |
The clinical and experimental studies on the metabolism of folic acid using tritiated folic acid. II. The experimental studies on the absorption site and mechanism of tritiated folic acid in rats.
Topics: Animals; Body Weight; Digestive System; Dinitrophenols; Folic Acid; Folic Acid Deficiency; Gastric Mucosa; Ileum; Jejunum; Kidney; Liver; Male; Methotrexate; Radiometry; Rats; Tritium | 1968 |
The clinical and experimental studies on the metabolism of folic acid using tritiated folic acid. 3. Plasma clearance in man and organ distribution in rat following intravenous administration of tritiated folic acid.
Topics: Acute Disease; Animals; Body Weight; Bone Marrow; Carbon Tetrachloride; Chronic Disease; Folic Acid; Hematologic Diseases; Humans; Injections, Intravenous; Kidney; Leukemia; Liver; Liver Diseases; Methotrexate; Rats; Spleen; Tritium | 1968 |
[Addenda to the study of the effect of carcinostatic drugs on human beings. I. Death rate of young and adult albino rats after administration of sublethal doses, equally divided per body weight].
Topics: Age Factors; Animals; Body Weight; Mechlorethamine; Methotrexate; Mitomycins; Rats | 1968 |
[Addenda to the study of the effect of carcinostatic drugs on human beings. II. Variations in peripheral blood in young and adult albino rats after administration of sublethal doses, equally divided per body weight].
Topics: Aging; Animals; Blood Cell Count; Blood Cells; Body Weight; Hemoglobins; Mechlorethamine; Methotrexate; Mitomycins; Rats | 1968 |
Methotrexate therapy for squamous cell carcinomas of the head and neck. Intermittent intravenous dose program.
Topics: Adult; Aged; Blood Cell Count; Body Weight; Carcinoma, Squamous Cell; Ear Neoplasms; Epiglottis; Facial Neoplasms; Humans; Injections, Intravenous; Laryngeal Neoplasms; Methotrexate; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Nasopharyngeal Neoplasms; Palatal Neoplasms; Pharyngeal Neoplasms; Tongue Neoplasms; Tonsillar Neoplasms | 1968 |
Vaccination of a patient receiving immunosuppressive therapy for lymphosarcoma.
Topics: Agammaglobulinemia; Aged; Animals; Autoimmune Diseases; Body Weight; Female; Globulins; Guinea Pigs; Humans; Immunosuppressive Agents; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Prednisone; Skin Tests; Smallpox Vaccine; Travel | 1966 |
[Group drug therapy in acute leukemia in childhood. Report of experiences in the USA].
Topics: Ambulatory Care; Animals; Body Height; Body Weight; Bone Marrow Examination; Child; Humans; Leukemia; Methotrexate; Mice; Pediatric Nursing; Prednisone; Societies, Medical; Terminal Care; United States; Vincristine | 1966 |