methotrexate has been researched along with Benign Neoplasms in 1180 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 725 (61.44) | 18.7374 |
| 1990's | 106 (8.98) | 18.2507 |
| 2000's | 94 (7.97) | 29.6817 |
| 2010's | 175 (14.83) | 24.3611 |
| 2020's | 80 (6.78) | 2.80 |
| Authors | Studies |
|---|---|
| Barrows, LR; Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ; Queener, SF | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L | 1 |
| Chui, WK; Lin, K; Ma, X; Zhou, W; Zhou, X | 1 |
| Li, H; Liu, J; Tian, C; Wang, M; Wang, X; Xue, L; Yang, J; Yuan, M; Zhang, Z | 1 |
| Jing, Y; Ojima, I; Wang, C; Wang, X | 1 |
| Liu, L; Wang, W; Zhou, H | 1 |
| Gao, F; Wang, T; Xiao, J; Zhang, X | 1 |
| Akbarizadeh, AR; Batta, G; Behzadi, M; Borazjani, N; Brunel, JM; Digiorgio, C; Ghanbari, MM; Ghasemi, Y; Jarrahpour, A; Mohkam, M; Rad, JA; Sasanipour, M; Sepehri, S; Turos, E | 1 |
| Xu, Z; Zhang, L | 1 |
| Duvic, M; Joshi, TP | 1 |
| Choi, KH; Gwak, HS; Han, JM; Lee, HH | 1 |
| Ali, A; Darnell, AM; Joesch-Cohen, L; Kunchok, T; Lewis, CA; Rees, MG; Reilly, MF; Rosenberg, D; Roth, JA; Sullivan, MR; Vander Heiden, MG | 1 |
| González-Menchen, A; Núñez-Córdoba, JM; Redondo, P; Salido-Vallejo, R; Sanz-Cabanillas, JL; Vélez, A | 1 |
| Badia, X; Cabero-Martínez, A; de la Fuente, A; Del Cerro, I; Domínguez-Pinilla, N; Gallardo, E; Giró-Perafita, A; González-Barca, E; Gros, L; Roldán, A; Tasso, M; Torrent, M | 1 |
| Cadena, J; Chan, KHR; Gryshuk, AL; Hong, JC; Huang, FW; Kwon, DH; Nguyen, S; Ray, P; Soper, B | 1 |
| Bargetzi, M; Daetwyler, E; Otth, M; Scheinemann, K | 1 |
| Aboelghar, HM; El-Deeb, SM; Elharoun, MS; Elsalam, HBA; Mahmoud, AAS; Zanaty, FM | 1 |
| Goel, N; Kumar, N | 1 |
| Huang, W; Jia, F; Jiang, Y; Su, W; Wang, H; Wang, X; Yin, Y; Zhang, J | 1 |
| Ahmadi, H; Akbari, ME; Barati, M; Davoodi, SH; Jabbari, M; Khaki Bakhtiarvand, V; Nikmehr, P; Shabani, M | 1 |
| Guo, J; Pan, H; Pan, W; Wang, T; Yun, K; Zhang, X; Zhu, R | 1 |
| Bs, U; K, RP; M Joseph, M; R, S; Sen, A; Tt, S | 1 |
| Jiang, R; Mei, S; Zhao, Z | 1 |
| Inal, J; Malibha-Pinchbeck, M; Stratton, D | 1 |
| Barreto, JN; Buddington, RK; Combs, R; Guscott, M; Heldrup, J; Howard, SC; Hurmiz, C; Ibarra, M; Lowe, J; Marada, S; Mikkelsen, T; Ramsey, LB; Schaiquevich, P; Taylor, ZL | 1 |
| Chen, Q; Ding, Y; Gu, R; Hu, Y; Huang, Z; Jiang, H; Yu, Y; Zhang, Z | 1 |
| Chang, YT; Chou, YJ; Pan, TY; Wu, CY | 1 |
| Cheong, TC; Chiarle, R; Culhane, AJ; Jang, A; Jones, JK; Kanarek, N; Lehtinen, MK; Petrova, B; Shipley, FB; Wong, ET; Zawadzki, ME | 1 |
| Chen, S; Wu, Y; Zhu, J | 1 |
| Farasat, A; Hajiahmadi, F; Ranjbarian, F; Shariatifar, H | 1 |
| Guan, H; Harrold, LR; Karis, E; Middaugh, N; Solomon, DH; Stryker, S; Yoshida, K | 1 |
| Aletaha, D; Balsa, A; Bathon, JM; Bergstra, SA; Buch, MH; Burmester, GR; Buttgereit, F; Caporali, R; Cardiel, MH; Chatzidionysiou, K; Codreanu, C; Cutolo, M; de Souza, S; den Broeder, AA; Edwards, CJ; El Aoufy, K; Finckh, A; Fonseca, JE; Gottenberg, JE; Haavardsholm, EA; Hyrich, KL; Iagnocco, A; Kerschbaumer, A; Landewé, RBM; Lauper, K; Li, Z; McInnes, IB; Mysler, EF; Nash, P; Poor, G; Pope, JE; Ristic, GG; Rivellese, F; Rubbert-Roth, A; Schulze-Koops, H; Sepriano, A; Smolen, JS; Stamm, TA; Stoilov, N; Strangfeld, A; Takeuchi, T; van der Heijde, D; van der Helm-van Mil, A; van Duuren, E; Verschueren, P; Vliet Vlieland, TPM; Westhovens, R; Winthrop, KL | 1 |
| Hyun, H; Jo, G; Kim, EJ; Park, MH | 1 |
| Bernsen, EC; Diekstra, M; Hanff, LM; Haveman, LM; Huitema, A; Swen, JJ; Tops, B; van der Lee, M | 1 |
| He, J; Shi, G; Wang, J; Zhang, M | 1 |
| An, X; Huang, B; Shi, Y; Zhang, L | 1 |
| Krüger, K | 1 |
| Chandra, P; Dkhar, DS; Dubey, VK; Kumar, R; Kumari, R; Mahapatra, S; Prerna, K; Srivastava, VR | 1 |
| Mikolajczyk, A; Puzyn, T; Sengottiyan, S | 1 |
| Chi, QN; Du, SS; Fu, XY; Jia, SX; Li, Z; Ma, YN; Qi, YK; Sun, MP; Wang, LE; Yin, H | 1 |
| Fang, L; Gao, C; Lu, X; Shao, W; Wang, H; Yang, X; Zhu, P | 1 |
| Dilmaghani, A; Hosseini, K; Tarhriz, V; Yousefi, V | 1 |
| Kumar, M; Rani, V; Verma, R | 1 |
| Chen, Y; Jiao, Z; Wang, C; Wang, X; Wang, Z; Yang, Y | 1 |
| Adas, MA; Adeyemi, O; Alveyn, E; Atzeni, F; Chan, CKD; Cope, AP; Galloway, JB; Ng, KKH; Norton, S; Patel, V; Russell, MD; Rutherford, AI; Stovin, C | 1 |
| Gulle, K; Ilhan, I; Sarman, E | 1 |
| Ambre, P; Coutinho, E; Gupta, C; Singh, P; Vaidya, S | 1 |
| Chen, K; Dong, L; He, H; Jiang, T; Pan, Z; Pang, X; Song, Y; Wang, M; Yang, G; Ye, X; Zhou, T | 1 |
| Acharya, NR; Artornsombudh, P; Begum, HA; Bhatt, NP; Buchanich, JM; Daniel, E; Dreger, KA; Dunn, JP; Fitzgerald, TD; Foster, CS; Gangaputra, SS; Goldstein, DA; Helzlsouer, KJ; Holland, GN; Jabs, DA; Kaçmaz, RO; Kempen, JH; Khachatryan, N; Kothari, S; Leiderman, YI; Levy-Clarke, GA; Liesegang, TL; Lowder, CY; Maghsoudlou, A; Newcomb, CW; Nussenblatt, RB; Pak, CM; Payal, AR; Pujari, SS; Read, RW; Rosenbaum, JT; Sen, HN; Sobrin, L; Suga, HK; Suhler, EB; Thorne, JE; Washington, TL | 1 |
| Clay, S; Doss, J; Fang, Z; Moore, B; Musso, A; Norman, M; Prasad, P; Sheets, G; Tsien, F; Umrigar, A | 1 |
| Fu, Z; He, Y; Huang, L; Kong, J; Ouyang, H; Xue, J; Zhang, Y; Zhu, Z | 1 |
| Inose, R; Muraki, Y; Nakamura, A; Omi, R; Takeno, S | 1 |
| Farmani, AR; Ghasemi, Y; Hemmati, S; Moradbeygi, F | 1 |
| De Wael, K; Detamornrat, U; Domínguez-Robles, J; Donnelly, RF; Parrilla, M; Tunca, S | 1 |
| Gaber, M; Ghareeb, D; Hamed, A; Hamed, M; Mohamed, TM; Nofal, MS | 1 |
| Keller, M; Sherban, A | 1 |
| Ahmed, OM; El-Sherbiny, IM; Fytory, M; Mansour, A; Rahman, FESA | 1 |
| Dutta, P; Li, J; Li, WX; Loyola, AC; Shang, R; Zhang, L | 1 |
| Buchmann, J; Calderón, M; Laufer, J; Molina, M; Theune, LE; Wedepohl, S | 1 |
| Becker, G; Levêque, D | 1 |
| Francis, S; Luben, R; Mead, A; Snowden, JA; Sousos, N; Thomas, S; Zeidler, MP | 1 |
| Capparelli, EV; Kawakatsu, S; Kuo, DJ; Le, S; Lin, M; Nikanjam, M; Saunders, I | 1 |
| Aardsma, N; Cabay, RJ; Chowdhery, R; Danciu, OC; Dudek, AZ; Emmadi, R; Fischer, JH; Gaitonde, S; Kothari, R; Liu, LC; Russell, MJ; Venepalli, NK; Zaidi, A | 1 |
| Eich, ML; Robinson, AD; Varambally, S | 1 |
| Bojko, A; Charzynska, A; Czarnecka-Herok, J; Dabrowski, M; Sikora, E | 1 |
| Hashimoto, N; Hosomi, K; Inose, R; Takada, M; Yokoyama, S | 1 |
| Ben Mrad, M; Bosacki, C; Bousarsar, A; Daguenet, E; Guillaume, E; Jmour, O; Lahmamssi, C; Magné, N; Vallard, A; Vial, N | 1 |
| Cai, Z; Hou, Z; Li, Y; Lin, J; Liu, J; Liu, X; Luo, Q; Wang, P; Yao, C; Zhang, Y | 1 |
| Hasan, T; Maytin, EV | 1 |
| Farshbaf, M; Gholikhani, T; Mahmoudian, M; Mohammadi, S; Mussa Farkhani, S; Nokhodchi, A; Shahbazi Mojarrad, J; Shirani, A; Valizadeh, H; Zakeri-Milani, P | 1 |
| Filtz, M; Kramer, E; Pace, M | 1 |
| Fan, Z; Ge, D; Han, J; Hou, Z; Huang, D; Jiang, B; Su, G; Tu, L; Xiang, S; Yang, Y; Zhao, Q; Zhu, Q | 1 |
| Annequin, D | 1 |
| Allenbach, Y; Benesova, K; Bingham, CO; Calabrese, LH; Choy, EH; Cope, AP; Finckh, A; Gottenberg, JE; Haanen, JBAG; Jamal, S; Kostine, M; Lambotte, O; Larkin, J; Leipe, J; Marabelle, A; Mariette, X; Radstake, TRDJ; Rusthoven, C; Schaeverbeke, T; Schulze-Koops, H; Thomasen, L; Visser, K; Visser, M | 1 |
| Muhammad, N; Rizvi, SAA; Saleh, AM; Shahzad, Y | 1 |
| Chesori, R; Gniazdowska, E; Halik, PK; Koźmiński, P | 1 |
| Cheng, Z; Chin, FT; Ding, B; Klockow, JL; Lau, K; Liu, H; Zhang, Y; Zhao, N | 1 |
| Gieselman, LA; Mancini, RS; Matta, SF | 1 |
| Fan, Z; Hou, Z; Li, Y; Tian, H; Wang, F; Xue, K; Zhao, Q; Zhu, F | 1 |
| Abid, NB; Kim, D; Kim, Y; Lee, G; Lee, KW; Parate, S; Rampogu, S; Rana, RM; Yoon, S; Zeb, A | 1 |
| Gupta, J; Gupta, R; Mishra, MK | 1 |
| Kosmidou, M; Milionis, H; Papamichail, G | 1 |
| Kanarek, N; Petrova, B | 1 |
| Annunziata, MC; Apalla, Z; Carrera, C; Fabbrocini, G; Fattore, D; Giacchero, D; Lallas, A; Lallas, K; Lazaridou, E; Nikolaou, V; Ortiz-Brugués, A; Patri, A; Peris, K; Riganti, J; Rigopoulos, D; Romano, MC; Rossi, E; Sibaud, V; Sollena, P; Stratigos, AJ; Voudouri, D | 1 |
| Fassihi, A; Gharieh, A; Mahdavian, AR; Najafipour, A; Sadeghi-Aliabadi, H | 1 |
| Attri, A; Kaur, T; Kumar, D; Peng, Z; Sensale, S; Singh, RP; Thakur, D | 1 |
| Aaltonen, K; Aarrestad Provan, S; Askling, J; Ballegaard, C; Cordtz, R; Delcoigne, B; Dreyer, L; Gudbjornsson, B; Hellgren, K; Kristensen, LE; Love, TJ; Nordström, D; Sexton, J; Zobbe, K | 1 |
| Abraham, RT; Boldajipour, B; Chaparro-Riggers, J; Deng, X; Johnson, TO; Kimberlin, C; Lin, R; Lindquist, KC; Mak, YSL; Melton, Z; Park, S; Pascua, E; Pons, J; Sasu, BJ; Van Blarcom, TJ | 1 |
| Kajikawa, K; Kataoka, T; Matsuo, H; Saeki, Y; Sakurashita, H; Taogoshi, T | 1 |
| Phillips, B; Proudfoot, RH | 1 |
| Dehghan, G; Hamishekar, H; Hosseinpour Feizi, MA; Khalili, L; Sheibani, N | 1 |
| Frühauf, J; Gangjee, A; Hou, Z; Matherly, LH; Ning, C; O'Connor, C; Tong, N; Wallace-Povirk, A | 1 |
| Carleton, BC; Esperón, P; Gemmati, D; Heil, SG; Hoerning, S; Jabeen, S; Lopéz-Lopéz, E; Maagdenberg, H; Maitland-van der Zee, AH; Moreno-Galván, M; Oosterom, N; Ruiz-Argüelles, GJ; Sleurs, C; van den Heuvel-Eibrink, MM; Windsor, RE; Zanen, J; Zolk, O | 1 |
| Foppoli, M; Manca, D; Pesenti, G | 1 |
| Garcia, H; Grangé, S; Rafat, C | 1 |
| Chen, Q; Guo, Y; Li, Q; Li, Y; Ma, J; Song, H; Zhang, Y; Zhao, D; Zhou, X; Zhu, X | 1 |
| Chantry, AD; Chinnaiya, K; Down, J; Green, A; Haider, MT; Hughes, D; Lawson, MA; Sayers, JR; Snowden, JA; Thomas, S; Zeidler, MP | 1 |
| Chaudhuri, AS; Fan, Y; Han, X; Huo, M; Li, W; Qi, X; Wu, Z; Yang, C | 1 |
| Chen, KM; Hassanshahi, M; Howe, PR; Su, YW; Tang, Q; Xian, CJ | 1 |
| Li, XL; Liu, YW; Nie, XL; Wang, SZ; Wang, XL; Yu, XT; Zhao, LB; Zhu, C | 1 |
| Arnold, DE; Bunin, NJ; Elgarten, CW; Seif, AE | 1 |
| Boratyński, J; Filip-Psurska, B; Goszczyński, TM; Kmiecik, SW; Krzyścik, MA; Wietrzyk, J | 1 |
| Harrison, DD; Hsia, EC; Husni, ME; Kavanaugh, A; Kim, L; Leu, JH; Lo, KH | 1 |
| Fakharzadeh, S; Fiorentino, D; Galindo, C; Goyal, K; Ho, V; Hopkins, L; Langholff, W; Langley, RG; Lebwohl, MG; Leite, L; Srivastava, B | 1 |
| Cerminara, Z; Duffy, A; Gilmore, S; Nishioka, J; Trovato, J | 1 |
| Hou, Z; Li, Y; Lin, J; Luo, FH; Ma, J; Pan, Z; Song, L; Su, G; Ye, S; Zhang, Y; Zhu, X | 1 |
| Askenazi, D; Balis, FM; Bergeron, S; Bleyer, A; Heldrup, J; O'Brien, MM; Pauley, JL; Ramsey, LB; Schmiegelow, K; Schwartz, S; Shirali, A; Vinks, AA; Widemann, BC | 1 |
| Bernhardt, MB; Haworth, TE; Reichert, KE; Schafer, ES; Shah, MD | 1 |
| Duan, X; Fang, Y; Jiang, Z; Jin, S; Li, M; Li, Q; Liu, J; Liu, Y; Shi, X; Tian, X; Wang, Q; Wang, Y; Wu, R; Yu, C; Zeng, X; Zhao, Y | 1 |
| Cheng, A; Hou, Z; Jin, X; Wu, S; Xie, W; Yang, L; Yang, X | 1 |
| Chatterjee, B; Ghosh, SS; Raza, A | 1 |
| Çuburu, N; King, EM; Mazor, R; Pastan, I | 1 |
| Fan, Z; Hou, Z; Li, Y; Su, G; Xie, J; Xie, L; Yu, F; Zhang, Y | 1 |
| Chernobrovkin, A; Pirmoradian, M; Sabatier, P; Saei, AA; Tokat, ÜG; Zubarev, RA | 1 |
| AlQhatani, AD; Bashraheel, SS; Dömling, A; Goda, SK; Groves, MR; Rashidi, FB; Shaabani, S | 1 |
| Matsuoka, Y; Narukawa, M | 1 |
| Chen, D; Chen, Y; Hou, Z; Li, Y; Li, Z; Liu, Q; Ma, J; Qian, K; Ruan, H; Zhou, X; Zhu, X | 1 |
| Aghajanzadeh, M; Danafar, H; Rashidzadeh, H; Rostamizadeh, K; Sharafi, A; Zamani, M | 1 |
| Costa, D; Queiroz, JA; Sousa, Â; Valente, AJM | 1 |
| Abu-Remaileh, M; Cantor, JR; Chan, SH; Freinkman, E; Kanarek, N; Keys, HR; Kunchok, T; Lewis, CA; Sabatini, DM; Schweitzer, LD | 1 |
| Bai, S; Gao, YE; Hou, M; Kang, Y; Li, B; Ma, X; Shi, X; Xiao, B; Xu, Z; Xue, P | 1 |
| Frezza, C | 1 |
| Arana, S; Mitxelena-Iribarren, O; Mujika, M; Zabalo, J | 1 |
| Chung, RJ; Dhawan, U; Li, YQ; Lin, C; Liu, WC; Liu, XR; Wu, KT; Wu, YC; Xu, M; Zhao, G | 1 |
| Al-Mansoori, L; Al-Yafei, A; AlQahtani, AD; Bashraheel, SS; Domling, A; Elsinga, P; Goda, SK; Rashidi, FB | 1 |
| Atallah, EL; Canadeo, AM; Frank, JP; Lorge, AH; Nowak, TJ; Rein, LE; Samanas, LC; Urmanski, AM | 1 |
| Chen, J; Chen, X; Chen, Y; Tan, X; Wang, J; Yang, Z | 1 |
| Akhtar, N; Farook, AS; Girigoswami, A; Girigoswami, K; Haribabu, V; Sharmiladevi, P | 1 |
| Amini, A; Bidram, E; Cho, HJ; Dunstan, DE; Harris, T; Qiao, G; Stewart, A; Sulistio, A; Zarrabi, A | 1 |
| Blenis, J; Cantley, LC; Cheng, Z; Fei, DL; Lee, G; Li, Q; Lin, TY; Momb, J; Paddock, MN; Ramsamooj, S; Stein, BD; Zhang, G; Zheng, Y | 1 |
| Cai, D; Chen, B; Kankala, RK; Liu, Y; Long, R; Wang, P; Wang, S | 1 |
| Dora, CP; Jain, S; Katiyar, SS; Kushwah, V | 1 |
| Bánfalvi, G; Fábián, I; Juhász, I; Kalmár, J; Király, G; Lázár, I; Nagy, G; Veres, P | 1 |
| Gorges, J; Höhn, M; Kazmaier, U; Kern, S; Truebenbach, I; Vollmar, AM; Wagner, E; Zahler, S | 1 |
| Ball, IA; Bowen, JM; Gibson, RJ; Shirren, J; van Sebille, YZA; Wanner, K; Wardill, HR; Wignall, A; Williams, N | 1 |
| Bernaczek, K; Grzywna, ZJ; Mielańczyk, A; Mielańczyk, Ł; Neugebauer, D | 1 |
| Abril-Molina, A; Alés-Palmer, M; Gómez-Luque, JM; Muñoz de Rueda, P; Ocete-Hita, E; Urrutia-Maldonado, E | 1 |
| Ahmed, S; Halim, MA; Khan, AM; Mazharol Hoque, M; Uddin, N | 1 |
| Al-Qahtani, AD; Bashraheel, SS; Domling, A; Goda, SK; O'Connor, CD; Rashidi, FB; Romero, AR | 1 |
| Abdollahi, Z; Bahrani, SA; Kajani, AA; Taheri-Kafrani, A | 1 |
| Chai, D; Hao, B; Hu, R; Huang, X; Jiang, H; Sun, Y; Yan, J; Zhang, F; Zhang, Q | 1 |
| Duan, X; Li, C; Song, L; Yang, X | 1 |
| Carleton, BC; Hayden, MR; Rassekh, SR; Ross, CJ | 1 |
| Chen, Y; Fang, C; Feng, W; Peng, S; Wang, W; Wang, X; Wang, Y; Yan, C; Zhao, M | 1 |
| Chen, Y; Fan, Z; Fang, X; Gu, J; Ren, Q; Sha, X; Zhang, W; Zhong, W | 1 |
| D'Hondt, L; Kerger, J; Mouzon, A; Spinewine, A | 1 |
| Aydin, F; Canturk, T; Senturk, N; Turanli, AY; Yuksel, EP | 1 |
| Jie, J; Liu, Z; Tian, B; Yang, Y; Zhang, X; Zhou, M | 1 |
| Bian, S; Fan, Y; Huang, Y; Liang, J; Sun, Y; Zhang, X | 1 |
| Curtis, JR; Fisher, M; Furer, V; Greenberg, JD; Harrold, LR; Hochberg, MC; Kremer, JM; Reed, G; Solomon, DH; Tsao, P | 1 |
| Cohen, IJ | 1 |
| Bateman, E; Bowen, J; Greenberg, N; Keefe, D; Mayo, B; Plews, E; Schiffrin, E; Stringer, A; Wignall, A | 1 |
| Godefroid, MJ; Parsch, H; Stove, V; Streichert, T; Verstraete, AG; von Meyer, A | 1 |
| Afshari, M; Derakhshandeh, K; Hosseinzadeh, L | 1 |
| Huang, C; Kang, ET; Lu, S; Neoh, KG; Shi, Z | 1 |
| Bertino, JR; Boros, LG; Chan, LL; DiPaola, RS; Dolfi, SC; Dvorzhinski, D; Gounder, M; Hirshfield, KM; Lin, H; Markert, EK; Oltvai, ZN; Qiu, J; Tedeschi, PM; Vazquez, A | 1 |
| Chen, J; Fang, M; Huang, L; Lai, H; Lu, C; Luo, X; Zhang, Q | 1 |
| D'Elia, T | 1 |
| Hou, Z; Matherly, LH; Wilson, MR | 1 |
| Bobrovnikova-Marjon, E; Hurov, JB | 1 |
| Dörner, T; Emery, P; Fisheleva, E; Martin, C; Millar, L; Olech, E; Rigby, W; Tak, PP; Travers, H | 1 |
| Buchholz, B; Dürken, M; Karremann, M; Meier, C; Mildenberger, S; Sauerbier, J; Schneider, H; Vetter, C | 1 |
| Goldman, ID; Unal, ES; Visentin, M | 1 |
| Dixon, WG; Hyrich, KL; Low, AL; Lunt, M; Mercer, LK; Symmons, DP; Watson, KD | 1 |
| Chen, H; Fan, W; Liu, Y; Yu, MX | 1 |
| Dang, Y; Gao, C; Guo, J; He, G; Kong, X; Liu, T; Wang, W; Yin, Y; Yu, Z; Zhang, X; Zheng, H | 1 |
| Castellino, SM; Lange, BJ; Ullrich, NJ; Whelen, MJ | 1 |
| Chang, CW; Gau, JJ; Horng, JT; Huang, JL; Kok, VC; Yeh, KW; Zhuang, LZ | 1 |
| Chang, YT; Chen, CC; Chen, DY; Chen, YJ; Ho, HJ; Kuo, KN; Liu, HN; Shen, JL; Wu, CY | 1 |
| Hakala, M; Häkkinen, A; Järvenpää, S; Kautiainen, H; Salomaa, S; Uutela, T | 1 |
| Ascher, DB; Chan, LJ; Finnin, BA; Haynes, JM; Jones, S; Kaminskas, LM; Kelly, BD; McLeod, VM; Owen, DJ; Porter, CJ; Ryan, GM; Sloan, EK; Trevaskis, NL; Velkov, T; Williams, ED; Williamson, M | 1 |
| Choi, SK; Wong, PT | 1 |
| Cui, F; Hou, Z; Jia, M; Li, Y; Lin, J; Luo, F; Wu, H; Wu, S; Xie, L; Yang, X; Ye, S; Yu, F | 1 |
| Wissing, MD | 1 |
| Masson, JF; Pelletier, JN | 1 |
| Mager, DR | 1 |
| Morikawa, N | 1 |
| Yoshida, M | 1 |
| Bartlett, JM; Caldas, C; Cameron, DA; Cardoso, F; Desmedt, C; Di Leo, A; Dunn, JA; Earl, HM; Ejlertsen, B; Jensen, MB; Larsimont, DP; McConkey, CC; Munro, AF; O'Malley, FP; Poole, CJ; Pritchard, KI; Rea, DW; Shepherd, LE; Twelves, CJ | 1 |
| Haas, JP; Horneff, G; Huppertz, HI; Klotsche, J; Minden, K; Niewerth, M; Zink, A | 1 |
| Araújo, TE; Borba, PB; da Silva, AI; de Araújo Júnior, RF; de Araújo, AA; de Souza, FH; Nogueira, AC; Saldanha, TS | 1 |
| Hou, Z; Li, Y; Lin, C; Lin, J; Luo, F; Wu, H; Xie, L; Yu, F; Zhou, S | 1 |
| Entezami, AA; Namazi, H; Toomari, Y | 1 |
| Devauchelle-Pensec, V; Guellec, D | 1 |
| Akbar, EA; Namazi, H; Toomari, Y | 1 |
| Kuang, ZP; Li, Y; Li, YD; Liang, NS; Yang, F | 1 |
| Augustin, M; Mrowietz, U; Radtke, MA; Reich, K; Rustenbach, SJ; Spehr, C; Thaci, D | 1 |
| Bang, SM; Cho, KM; Han, JH; Kim, CY; Kim, IA; Kim, JH; Kim, JS; Kim, JW; Kim, SH; Kim, YJ; Lee, JO; Lee, JS; Lee, KW | 1 |
| Cai, Y; Chen, M; Fang, X; He, C; Li, P; Wang, Y; Xiao, F | 1 |
| Ariga, T; Cho, Y; Iguchi, A; Kobayashi, R; Ohshima, J; Sato, TZ; Sugiyama, M; Terashita, Y | 1 |
| Effinger, KE; Link, MP | 1 |
| Ara, M; Bordas, X; Carrascosa, JM; Carretero, G; Coto-Segura, P; Daudén, E; de la Cueva, P; Ferrándiz, L; Herranz, P; Jorquera, E; López-Estebaranz, JL; Puig, L; Ribera, M; Sánchez-Carazo, JL; Vidal, D | 1 |
| Ahmad, A; Kazi, MS | 1 |
| Durmus, S; Schinkel, AH; van Hoppe, S | 1 |
| Charpentier, C; Cheddani, H; Dauchet, L; Dupas, JL; Fumery, M; Gower-Rousseau, C; Marie Bouvier, A; Pariente, B; Peyrin-Biroulet, L; Savoye, G | 1 |
| Exton, LS; Kirby, B; Mohd Mustapa, MF; Smith, CH; Warren, RB; Weatherhead, SC; Yesudian, PD | 1 |
| Arsalani, N; Entezami, AA; Ghorbani, M; Hamishehkar, H | 1 |
| Bergeron, JR; Flaherty, P; Giaever, G; Mellor, JC; Nislow, C; Sinha, S; Wong, LH | 1 |
| Cipolleschi, MG; Dello Sbarba, P; Marzi, I; Olivotto, M; Rovida, E | 1 |
| Chu, Y; Ma, P; Mu, H; Ni, L; Sun, K; Wang, Y; Xing, P; Yu, H; Zhang, X | 1 |
| Davies, R; Hyrich, KL; Kearsley-Fleet, L; Kihara, M; Lunt, M; Symmons, DP; Watson, KD | 1 |
| Bąk, A; Dybał, P; Jampilek, J; Kozik, V; Pentak, D; Sochanik, A | 1 |
| Funding, AT; Grønbæk, H; Heickendorff, L; Heidenheim, M; Iversen, L; Kyvsgaard, N; Lindberg, R; Madsen, JT; Raaby, L; Skov, L; Strauss, G; Thielsen, P; Zachariae, C; Østensen, M | 1 |
| Darko, KO; He, C; Huang, Y; Liu, Z; Peng, M; Su, Q; Tao, T; Yang, X; Yin, T | 1 |
| Bajwa, RPS; Gerhardt, CA; Hagedoorn, M; Keim, MC; Lehmann, V; Olshefski, RS; Tuinman, MA; Winning, AM | 1 |
| Buchbinder, R; Hossain, A; Lopez-Olivo, MA; Maxwell, LJ; Mudano, AS; Singh, JA; Suarez-Almazor, ME; Tanjong Ghogomu, E; Tugwell, P; Wells, GA | 1 |
| Grönroos, MH; Irjala, K; Jahnukainen, T; Möttönen, M; Perkkiö, M; Salmi, TT | 1 |
| Barbarot, V; Courant-Menanteau, M; Lewden-Bernadac, B; Perrocheau, G; Thomare, P | 1 |
| Gottlieb, AB; Korman, N; Krueger, GG; Sterry, W; Van De Kerkhof, P | 1 |
| Daniel, E; Foster, CS; Gangaputra, S; Helzlsouer, KJ; Jabs, DA; Kempen, JH; Levy-Clarke, GA; Nussenblatt, RB; Rosenbaum, JT; Suhler, EB; Thorne, JE | 1 |
| Botturi, A; Bruzzone, MG; Ciceri, E; Erbetta, A; Potepan, P; Salmaggi, A; Sghirlanzoni, A; Silvani, A | 1 |
| Ellenbogen, RG; Fang, C; Hansen, S; Lee, D; Olson, J; Stephen, Z; Sun, C; Veiseh, O; Zhang, M | 1 |
| Krajinovic, M; Marcoux, S; Moghrabi, A; Robaey, P | 1 |
| Bharti, AC; Das, BC; Dutta, T; Jain, NK; Tekade, RK; Tyagi, A | 1 |
| Altschuler, SJ; Martinez, ED; Slack, MD; Wu, LF | 1 |
| Salliot, C; van der Heijde, D | 1 |
| Doki, K; Homma, M; Hori, S; Kohda, Y; Ohtani, H; Sawada, Y; Suzuki, K; Tamaki, H | 1 |
| Fukuhara, K; Ikawa, K; Kumagai, K; Morikawa, N | 1 |
| De Mattia, E; Toffoli, G | 1 |
| Campos, D; Diaz, A; Izbicka, E; Saunders, M; Steffen, R; Streeper, R; Wick, M | 1 |
| Chen, ZS; Dai, CL; Fu, LW; Liang, YJ; Tiwari, AK; Tong, XZ; Wang, F; Wang, YS; Yan, YY | 1 |
| Alemany, R; Cascallo, M; Fillat, C; Martinez-Quintanilla, J | 1 |
| Dragnev, KH | 1 |
| Kim, YI | 1 |
| Alvarez, R; Busquets, X; Escribá, PV; Halver, JE; Higuera, M; Lladó, V; Noguera-Salva, MA; Terés, S | 1 |
| Barlett, N; Chen, CH; Grenier, K; Mujic, V; Sussman, H; Toepker, S; Waller, EK | 1 |
| Böhlke, M; Henry, K; Kim, J; Maher, TJ; Sani, SN; Stricker-Krongrad, A | 1 |
| Askling, J; Baecklund, E; Cöster, L; Dackhammar, C; Feltelius, N; Fored, CM; Geborek, P; Granath, F; Jacobsson, LT; Klareskog, L; Lindblad, S; Raaschou, P; Rantapää-Dahlqvist, S; Saxne, T; van Vollenhoven, RF | 1 |
| Dann, F; Gottlieb, AB | 1 |
| Baker, JR | 1 |
| O'Brien, T; Stokoe, D | 1 |
| Ashworth, A; Barber, LJ; Burgess, DJ; Lord, CJ; Martin, SA; McCarthy, A; Parry, S | 1 |
| Chamberlain, MC; Fisher, R; Glantz, MJ; Van Horn, A | 1 |
| English, JC; Hawryluk, EB; Izikson, L | 1 |
| Gullino, PM; Jain, RK; Wei, J | 1 |
| Bartegi, A; Ben Amor, N; Bouaziz, A; Mnif, W; Zidi, I | 1 |
| Horiike, S; Kanbayashi, Y; Matsumoto, Y; Nomura, K; Okamoto, K; Takagi, T; Taniwaki, M | 1 |
| Boos, J; Frühwald, MC; Gerss, J; Hempel, G; Mühlisch, J; Niemann, A | 1 |
| Castranova, V; Guo, NL; Qian, Y; Rathnagiriswaran, S; Wan, YW | 1 |
| Kiran, VU; Krishna, DR; Nagulu, M; Nalini, Y; Reddy, YN | 1 |
| Herbrecht, R; Kemmel, V; Lescoute, A; Levêque, D; Santucci, R | 1 |
| Martini, A; Ruperto, N | 1 |
| Foeldvari, I; Horneff, G; Hospach, T; Minden, K; Moebius, D | 1 |
| Barrett, JS; Dombrowsky, E; Jayaraman, B; Narayan, M | 1 |
| Lutz, T; Mackensen, F | 1 |
| Pope, JE; Rieder, SW; Thompson, AE | 1 |
| Behrens, F; Burkhardt, H; Koehm, M | 1 |
| Froklage, FE; Heimans, JJ; Reijneveld, JC | 1 |
| Carleton, B; Castro-Pastrana, LI; Hayden, MR; Rassekh, SR; Ross, CJ; Shereck, E; Visscher, H | 1 |
| Dzurenkova, A; Kadasi, L; Minarik, G; Mladosievicova, B; Soltysova, A; Sufliarska, S; Turna, J | 1 |
| Fan, C; Georgiou, KR; King, TJ; Xian, CJ | 1 |
| Carrasco, MP; Enyedy, EA; Krupenko, NI; Krupenko, SA; Martinelli, A; Nuti, E; Rossello, A; Santamaria, S; Santos, MA; Tuccinardi, T | 1 |
| Blann, AD; Han, C; Harris, AL; Khan, OA; Kirichek, O; Middleton, MR; Patil, M; Payne, MJ; Protheroe, AS; Talbot, DC; Taylor, M | 1 |
| DeAngelis, LM; Graber, JJ; Rosenblum, MK | 1 |
| Jasti, B; Kotamraj, P; Li, X; Russu, WA; Wu, J | 1 |
| Adamson, PC; Norris, RE; Rappaport, EF | 1 |
| Abud-Mendoza, C; Aranda, R; Becker, JC; Emery, P; Genant, HK; Kremer, JM; Li, T; Peterfy, C; Russell, AS; Szechinski, J; Westhovens, R; Zhou, X | 1 |
| Foster, BK; Hopwood, B; Shandala, T; Shen Ng, Y; Xian, CJ; Yip, YC | 1 |
| Gourieux, B; Herbrecht, R; Levêque, D; Santucci, R | 1 |
| Abed, S; Alla, CA; André, N; Gentet, JC; Orbach, D; Padovani, L; Pasquier, E; Verschuur, A | 1 |
| Baker, JR; Choi, SK; Desai, A; Kotlyar, A; Li, MH; Thomas, TP | 1 |
| Bai, JQ; Du, LQ; Du, XQ; Fan, FY; Liu, Q; Wang, H; Wang, XC; Wang, Y; Yang, QS; Zhao, P | 1 |
| Onel, K; Onel, KB | 1 |
| Bemrich-Stolz, CJ; Beukelman, T; Chen, L; Curtis, JR; Delzell, E; Haynes, K; Lewis, JD; Saag, KG; Solomon, DH; Xie, F | 1 |
| Jafari, M; Kislukhin, G; Long, AD; Murphy, ML | 1 |
| Kaykhaei, MA; Mashhadi, MA; Sanadgol, H | 1 |
| Dickinson, PD; Peel, DN; Sundar, S | 1 |
| Boddy, AV; Veal, GJ | 1 |
| Goldman, ID; Visentin, M; Zhao, R | 1 |
| Ahadi, F; Atyabi, F; Dinarvand, R; Khorramizadeh, MR; Taheri, A | 1 |
| Durgadas, CV; Sharma, CP; Sreenivasan, K | 1 |
| Baker, JR; Choi, SK; Desai, AM; Gam, J; Huang, B; Joice, M; Kotlyar, A; Silpe, JE; Thomas, TP; Zong, H | 1 |
| Anand, S; Hasan, T; Maytin, EV; Ortel, BJ; Pereira, SP | 1 |
| Bichelberger, MA; Colin, DY; Masson, JF; Pelletier, JN; Robitaille, R; Zhao, SS | 1 |
| Kang, ET; Li, M; Neoh, KG; Tan, JY; Wang, R; Zong, BY | 1 |
| Evangelista, M; Scharfe, C; Schlecht, U; St Onge, R | 1 |
| Bertino, JR; Tedeschi, PM; Vazquez, A | 1 |
| Feng, ZH; Huang, B; Katirai, F; Li, D; Liu, J; Lv, M; Ma, J; Shen, GX; Tang, K; Xu, P; Ye, D; Zhang, G; Zhang, H; Zhang, Y | 1 |
| Abolmaali, SS; Dinarvand, R; Tamaddon, AM | 1 |
| Brzosko, M; Burgos-Vargas, R; Fleischmann, RM; Halland, AM; Kremer, JM; Mela, C; Vernon, E | 1 |
| Büyüktıryakı, S; Genç, L | 1 |
| Dent, P; Fisher, PB; Gopalkrishnan, RV; Narayan, G; Su, ZZ | 1 |
| Aldaz, A; Aquerreta, I; Giráldez, J; Sierrasesúmaga, L | 1 |
| Bode, U; Jaehde, U; Vezmar, S | 1 |
| Bode, U; Diehl, V; Elter, T; Engert, A; Fleischhack, G; Heuer, T; Josting, A; Krause, AS; Weihrauch, MR | 1 |
| Hui, SW | 1 |
| Biedermann, E; Breiter, N; Jank, P; Jansen, G; Löser, R; Peters, GJ; Rattel, B; Wosikowski, K | 1 |
| Bravo-Hernández, G; Estrada, E; Gómez-Rangel, D; López-Martínez, B; Manuel Hernández, J; Marín-López, A; Ruiz-Argüelles, GJ | 1 |
| Aidi, S; Amarenco, P; El Amrani, M | 1 |
| Chamberlain, MC; Cole, BF; Glantz, MJ; Jaeckle, KA; Mackowiak, JI | 1 |
| Albertson, DG; Fridlyand, J; Jain, AN; Mans, DA; Pinkel, D; Segraves, R; Snijders, AM | 1 |
| Braun, S; Coith, C; Ebel, S; Hemsen, A; Jänicke, F; Kentenich, C; Oberhoff, C; Pantel, K; Riethdorf, S; Thurm, H; Wallwiener, D | 1 |
| COLSKY, J; GREENSPAN, EM; SCHOENBACH, EB | 1 |
| BENNETTE, JG | 1 |
| GOLDIN, A; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM | 1 |
| CAHILL, JJ; ZEIT, PR | 1 |
| VOGEL, AW | 1 |
| GOLOMB, FM; GUMPORT, SL; WRIGHT, JC | 1 |
| BUCKLE, AE | 1 |
| CONDIT, PT; OWENS, AH; SHNIDER, BI | 1 |
| HAMILTON, JK | 1 |
| BRENNHOVD, I; ENGSETH, A; STOVNER, J | 1 |
| ANDERSON, J; HELMAN, P; MALHERBE, E; SEALY, R | 1 |
| PITNEY, WR | 1 |
| GALVIN, C | 1 |
| AKASHI, A; HANO, K; IWATA, H | 1 |
| HENNING, N; WITTE, S | 1 |
| HERTZ, R | 2 |
| HOTCHIN, J | 1 |
| JACQUET, J | 1 |
| BENSON, JW; HOLDEN, WD; KIEHN, CL | 1 |
| BIERMAN, HR | 1 |
| BAGSHAW, MA | 1 |
| REEVE, TS | 1 |
| MEYER, NI; NORA, PF; SCANLON, EF; TARKINGTON, JA | 1 |
| SCHINDLER, R | 2 |
| CARAZZONE, PF | 2 |
| CURRO, S; FALCIDIA, E | 1 |
| BENSON, JW; DESPREZ, JD; KIEHN, CL | 1 |
| DOWNING, V; HUSEBY, RA | 1 |
| CONNOLLY, JM; MILLER, BJ; TALSANIA, SJ | 1 |
| DALY, JF; FRIEDMAN, M | 1 |
| BIANCO, AR; GLYNN, JP; GOLDIN, A; HUMPHREYS, SR; TRIVERS, G | 1 |
| EVANS, AM; RIEKHOF, P | 1 |
| BAGSHAWE, KD | 4 |
| BAGSHAW, MA; EIGENBODT, EH; NELSEN, TS | 1 |
| BASHORE, RA; LAGASSE, LD | 1 |
| DAWSON, EM | 1 |
| BERTINO, JR | 6 |
| NICHOL, CA | 3 |
| WESTBURY, G | 1 |
| ABBATUCCI, S; JACOB, P; JACQUET, J | 1 |
| ANDRE, P; DUFOUR, A | 1 |
| VELASCO, RN | 1 |
| WILTSHAW, E | 1 |
| ESTEVEZ, RA | 1 |
| PASCU, F; SUFRIN, W; VAGO, O | 1 |
| COSTAJDE, S; LIMA, RR | 1 |
| FREEMAN, RG; KNOX, JM; ROSSMAN, RE | 1 |
| MITANI, M; REISMAN, LE; ZUELZER, WW | 1 |
| D ANGIO, GJ; EVANS, AE; MITUS, A | 1 |
| GOLDENBERG, DM | 1 |
| BRULE, G; SCHLUMBERGER, J | 1 |
| SULLIVAN, RD; WATKINS, E | 2 |
| JOHNSTON, ID | 1 |
| BERTINO, JR; HELLMAN, S; IANNOTTI, AT | 1 |
| ARDAGH, JW; FOX, HW; SKELTON, CC | 1 |
| HICKEY, RC; JESSE, RH; LETAYF, V; RUFINO, C; VILLARREAL, R | 1 |
| MRAZEK, RG; SOUTHWICK, HW; STREHL, FW | 1 |
| FEIWEL, M; MUNRO, DD | 1 |
| KOGA, K; MAEDA, K | 1 |
| FREEMAN, RG; KNOX, JM; LANE, M; ROSSMAN, RE | 1 |
| FALLS, FH | 1 |
| IGLESIAS, F; KOKAME, GM; KREMENTZ, ET | 1 |
| RATNER, IA | 1 |
| BOWDEN, L | 1 |
| HAYES, DM; MEREDITH, JH; WILKINS, FB | 1 |
| DIPAOLO, JA | 1 |
| ARIEL, IM; GALEY, D; RESNICK, MI | 1 |
| SULLI, G | 1 |
| DARBY, CP | 1 |
| DARGENT, M; LESBROS, F; POMMATAU, E | 1 |
| BRANDKAMP, WW; MOORE, JG; VANCAMPENHOUT, JL | 1 |
| FERNBACH, DJ; SULLIVAN, MP; THURMAN, WG | 1 |
| MISRA, DK | 1 |
| CLIFFORD, P | 1 |
| VERNON, TM | 1 |
| ANDERSON, EP; BROCKMAN, RW | 1 |
| CHIRIGOS, MA; GLYNN, JP; GOLDIN, A; HUMPHREYS, SR; THOMAS, LB | 1 |
| KNOCK, FE | 1 |
| COBB, JP; WALKER, DG | 1 |
| BURCHENAL, JH; LYMAN, M; OETTGEN, HF; PURPLE, J | 1 |
| MILLER, E; SULLIVAN, RD | 1 |
| ESTRIN, J; PENG, BK; WEINBERG, SR; WESOLOWSKI, S | 1 |
| FREI, E; FREIREICH, EJ | 1 |
| LATHROP, JC | 1 |
| JOHNSON, NE; SISSON, GA | 1 |
| DIPAOLO, JA; DOWD, JE; WATNE, AL | 1 |
| HIGHMAN, JH; SUTTON, D | 1 |
| CARTMILL, TB; LOEWENTHAL, J; MILLS, FH | 1 |
| GOLDGRABER, MB; KIRSNER, JB | 1 |
| BIGNOTTI, G; TOGNELLA, S | 1 |
| AMBROSE, EJ; SHEPLEY, K; TCHAO, R; YARNELL, M | 1 |
| BIANCHI, F; CAZZOLA, D | 1 |
| MAIJNELLI, M; PERITI, P | 1 |
| LAWTON, RL | 1 |
| OETTGEN, HF | 1 |
| BEAHRS, OH; CALDAROLA, VT; HARRISON, EG | 1 |
| GASSER, C | 1 |
| MAGUDA, TA; WATSON, DR | 1 |
| ACQUARELLI, MJ; FEDER, RJ; GORDON, HE | 2 |
| HUTCHISON, JL | 1 |
| DONALDSON, SS; FLETCHER, WS | 1 |
| BRAME, JB | 1 |
| BURCHENAL, JH; MARIK, LR; NELSON, JH; STRAUB, PW | 1 |
| GASTPAR, H; SCHREINER, L | 1 |
| COPFERMAN, R; MENGUS, C; OUGIER, J | 1 |
| RUTMAN, RJ | 1 |
| DECOSSE, JJ; ROGERS, LS | 1 |
| BOLDREY, E; PHILLIPS, TL; SHELINE, GE | 1 |
| INNES, J | 1 |
| KESLER, K; MIALE, A | 1 |
| GOLOMB, FM; GUMPORT, SL; LYONS, MM; MEDREK, TJ; WALKER, DG; WRIGHT, JC | 1 |
| YANCEY, ST | 1 |
| KIRKHAM, JS | 1 |
| IZUCHI, S | 1 |
| BRAVER, SD; DAVID, S; GRIFFITHS, C; IRONS, R | 1 |
| HRESCHCHYSHYN, MM | 1 |
| GREENSPAN, EM | 1 |
| BENSON, JW; DAMM, H; DESPREZ, JD; KIEHN, CL | 1 |
| BYRON, RC; LAMB, EJ; MORTON, DG | 1 |
| NAHUM, AM | 1 |
| BOSTWICK, L; EVANS, JS; MENGEL, GD; MUSSER, EA | 1 |
| ROGERS, LS | 1 |
| SEELEN, JC | 1 |
| ANKER, HS; RENNERT, OM | 1 |
| BOLES, GW; COIN, JW; CONDIT, PT; MITCHELL, D; RIDINGS, GR; WILLIAMS, GR | 1 |
| BERNARD, J; BOIRON, M; BRIERE, J; DUMONT, J; LEVY, JP; MANUS, A | 1 |
| GREEN, A | 1 |
| HOBBS, J; HUDSON, PJ; KURZWEG, FT; MARTIN, DS; WHITE, HM | 1 |
| KEIDAN, SE; MAINWARING, D | 1 |
| BAKEN, MP | 1 |
| BOLANDE, RP; SMITH, JC | 1 |
| GRADY, ED | 1 |
| KNOERNSCHILD, H; PACE, WG | 1 |
| HUGULEY, CM; KERR, W; VOGLER, WR | 1 |
| REBOUL, R; SORSC, L | 1 |
| BOGLE, JM; BRUBAKER, CA; HAMMOND, D; HYMAN, CB; WILLIAMS, K | 2 |
| BISEL, HF; HULKA, JF | 1 |
| BOYLAND, E; KINDER, CH; WILLIAMS, K | 1 |
| MENGEL, CE | 1 |
| BUSCH, GJ; OWENS, AH | 1 |
| SATHE, Y; ZELEN, M; ZWEIFEL, J | 1 |
| BAKER, RR; GAERTNER, RA | 1 |
| CHAUVERGNE, J; HUGUES, A; LACHAPELE, AP; LAGARDE, C | 1 |
| BURKITT, D; HUTT, MS; WRIGHT, DH | 1 |
| ARNOLD, S | 1 |
| NIXON, HH | 1 |
| ANDERSON, RE; MORROW, LB | 1 |
| MCKELVEY, JL; MEEKER, HC; SPELLACY, WN | 1 |
| BERNARD, J; BOIRON, M; JACQUILLAT, C; NAJEAN, Y; SELIGMANN, M; WEIL, M | 1 |
| CASE, RW; GRAHAM, S; HELM, F; KLEIN, E; LAOR, Y; MILGROM, H; STOLL, HL; TRAENKLE, HL | 1 |
| HOGNESTAD, J; KOLSTAD, P | 1 |
| MORSE, PA; POTTER, VR | 1 |
| O'KEEFE, JJ; WEISS, AJ | 1 |
| AKIYOSHI, T; INOKUCHI, K | 1 |
| MOSS, G | 1 |
| HOBSON, BM | 1 |
| LOVELY, FW | 1 |
| CAVANAGH, D; HERNANDEZ-ROMAN, P; MARTIN, DS | 1 |
| LAZOGUERRA, A; MASFERRER, R | 1 |
| LUDMAN, H; PACKHAM, DA | 1 |
| ELLIOTT, GB; FISHER, BK | 1 |
| KEIDAN, SE | 2 |
| LEBHERZ, TB; PARKER, RT | 1 |
| FISCHER, GA; VONESSEN, CF | 1 |
| ALLEN, DM; DAMESHEK, W; FINKEL, HE; NECHELES, TF | 1 |
| BODEY, GP; BRECHER, G; FREIREICH, EJ; NIES, BA; THOMAS, LB | 1 |
| GOLDSTEIN, DP; HERTZ, R; LIPSETT, MB; ODELL, WD; ROSS, GT | 1 |
| WELCH, AD | 1 |
| OFSTAD, J | 1 |
| HALL, TC; NEVINNY, HB | 1 |
| Akaza, H; Konishi, T; Sasaki, T; Tsukuda, M | 1 |
| Chester, KA; Hawkins, RE; Pedley, RB; Sharma, SK | 1 |
| Lange, U; Strube, K; Strunk, J | 1 |
| Gao, F; Goldman, ID; Hanscom, M; Zhao, R | 1 |
| Hori, H; Kagawa, Y; Kawasaki, H; Kojima, M; Komada, Y; Mukohara, R | 1 |
| Ben-Ari, ET | 1 |
| Hachem, R; Hanna, H; Raad, I | 1 |
| Armstrong, TS; Gilbert, MR | 1 |
| Fleischmann, RM; Iqbal, I; Stern, RL | 1 |
| Ikarashi, Y; Imai, C; Kakihara, T; Tanaka, A; Uchiyama, M; Watanabe, A | 1 |
| Adamson, PC; Balis, FM; Boron, M; Castle, V; Cole, DE; Hermann, RC; Hinton, S; Ivy, P; Jayaprakash, N; Moertel, CL; Moussa, A; Muraszko, K; O'Brien, M; Poplack, D; Reaman, G; Shalabi, A; Trueworthy, R; Widemann, BC | 1 |
| Radina, M; Sterba, J; Valik, D; Vojtesek, B | 1 |
| de Anta, JM; Mayol, X; Real, FX | 1 |
| Cecchin, E; Toffoli, G | 1 |
| Kohler, N; Sun, C; Wang, J; Zhang, M | 1 |
| Chau, Y; Dang, NM; Langer, R; Padera, RF | 1 |
| Boynton, A; Robien, K; Ulrich, CM | 1 |
| Dodd, M; Dowling, G; Jansen, C; Kramer, J; Miaskowski, C | 1 |
| Isomura, M; Miki, Y | 1 |
| Walling, J | 1 |
| Guillevin, L | 1 |
| Jammaz, IA; Okarvi, SM | 1 |
| Keystone, EC; Kremer, JM; Martin, RW; Moreland, LW; Schiff, MH; Weinblatt, ME; White, BW; Whitmore, JB | 1 |
| Corzo, C; de Anta, JM; Espinet, B; Mayo, C; Mayol, X; Petzold, M; Real, FX; Salido, M; Serrano, S; Solé, F; Villa, O | 1 |
| Adamson, PC; Widemann, BC | 1 |
| Baas, P; Beijnen, JH; Huitema, AD; Joerger, M; Schellens, JH; Schornagel, JH; van den Bongard, HJ | 1 |
| Brody, JR; Canto, MI; Gallmeier, E; Hruban, RH; Hucl, T; Kern, SE; Kulesza, P; Schulick, RD; Yoshimura, K | 1 |
| Brunetto, AL; Castro, CG; Cruz, LB; Rech, A; Ribeiro, AS; Rosa, LG | 1 |
| Belinsky, MG; Chen, ZS; Guo, Y; Hopper-Borge, E; Kruh, GD | 1 |
| Whelan, P | 1 |
| Gerhardt, CA; Noll, RB; Vannatta, K; Wells, RJ | 1 |
| Ribatti, D | 1 |
| Bergstrom, DA; Cao, Y; Kooperberg, C; Tanaka, H; Tapscott, SJ; Yao, MC | 1 |
| Berthier, F; Clavelou, P; de Seze, J; Debouverie, M; Defer, G; Lebrun, C; Rumbach, L; Vermersch, P | 1 |
| Boogerd, W; du Bois, WF; Rosenbrand, CJ; Teepen, JL | 1 |
| Tohma, S | 1 |
| Albertioni, F; Cosic, K; Eksborg, S; Ritzmo, C; Söderhäll, S | 1 |
| Baehring, JM; Fulbright, RK | 1 |
| Mertens, AC; Ness, KK; Recklitis, C; Robison, LL; Schultz, KA; Whitton, J; Zebrack, B; Zeltzer, L | 1 |
| Ambudkar, SV; Ashby, CR; Bates, SE; Chen, ZS; Fu, LW; Kim, IW; Peng, XX; Robey, RW; Shen, T; Shi, Z; Shukla, S; Si, QS | 1 |
| Buss, DC; Hain, RD; Mashayekhi, SO; Routledge, PA | 1 |
| Auton, T; Borner, K; Fischer, L; Korfel, A; Martus, P; Müller, K; Schwartz, S; Thiel, E | 1 |
| THIERSCH, JB | 1 |
| Barrett, JS; Mondick, JT; Narayan, M; Vijayakumar, K; Vijayakumar, S | 1 |
| Kiely, JM; Pease, GL; Speck, B | 1 |
| Hersh, EM; Oppenheim, JJ | 1 |
| DesPrez, JD; Lehman, JA; Shinn, GL | 1 |
| Burn, JI | 1 |
| Gahrton, G; Lönnqvist, B; Lundgren, G; Ringdén, O; Wahren, B | 1 |
| Fekete, G; Schuler, D; Szollár, J | 1 |
| Ludwig, C | 1 |
| Knöll, P; Siering, H | 1 |
| Kappauf, H; Theissing, J | 1 |
| Herfarth, C; Schlag, P; Schreml, W; Vergani, G; Wolfrum, J | 1 |
| Ellims, PH | 1 |
| Moser, K; Pohl, A | 1 |
| Britton, PG; Craft, AC; Kernahan, J; Noble, TC; Twaddle, V | 1 |
| Chabner, BA; Clendeninn, NJ; Curt, GA | 1 |
| Rubin, P | 2 |
| Browman, GP | 1 |
| Markman, M | 3 |
| Coombs, A; Hanson, J; Moore, JL | 1 |
| Clarkson, AR; Healy, HG | 1 |
| Elslager, E; Lathan, B; Von Hoff, DD | 1 |
| Long, QC; Pan, QC | 1 |
| Janas, J; Kozaczka, A; Singer, Z; Wilk, J | 1 |
| Bagshawe, KD; Booth, M; Dent, J; Rustin, F; Rustin, GJ; Salt, S | 1 |
| Goto, M; Konishi, H; Tsuda, N; Yamashina, H | 1 |
| Christophidis, N | 1 |
| Chabner, BA; Clendeninn, NJ; Cowan, KH; Curt, GA; Jolivet, J | 1 |
| Begg, CB; Carbone, PP | 1 |
| Bertino, JR; Carman, MD; Cashmore, A; Dube, SK; Medina, WD; Moroson, BA; Schornagel, JH; Srimatkandada, S; Weiner, HL | 1 |
| Skipper, HE | 1 |
| Grzelakowska-Sztabert, B | 4 |
| Coates, AS; Fox, RM; Hedley, D; Raghavan, D; Swanson, C; Tattersall, MH | 1 |
| Taguchi, T | 2 |
| Göbel, U; Städtler, R; von Kries, R | 1 |
| Jackson, RC | 1 |
| Ojeda, VJ; Walters, MN | 1 |
| Safa, AR; Tseng, MT | 1 |
| Selby, P | 1 |
| Müller, U; Tanneberger, S | 1 |
| Hill, DL; Montgomery, JA | 1 |
| Mathe, G | 3 |
| Braun, DP; Harris, JE | 1 |
| Frei, E | 1 |
| Geissler, K; Lenzhofer, R; Moser, K; Schneeweiss, B | 1 |
| Champion, JE; Crom, DB; Crom, WR; Evans, WE; Green, AA; Pratt, CB; Stewart, CF | 1 |
| Baguley, BC; Finlay, GJ | 1 |
| Sauer, H | 1 |
| Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW | 1 |
| Abelson, HT; Beardsley, GP; Fosburg, MT; Goorin, AM; Gorka, C; Link, D; Link, M | 1 |
| Colls, BM; Robinson, BA; Robson, RA; Tisch, GW | 1 |
| Jensen, H; Nyfors, A | 1 |
| Pascual Gómez, E | 1 |
| Ensminger, WD; Gyves, JW | 1 |
| Chabner, BA; Cowan, KH; Curt, GA | 1 |
| Schimke, RT | 2 |
| Oberley, LW; Oberley, TD | 1 |
| Fujimoto, T; Sasaki, K; Tanaka, J | 1 |
| Clavel, B; Gest, J; Goupil, A; Lokiec, F; Meeus, L; Tubiana-Hulin, M; Turpin, F | 1 |
| Cadman, EC | 1 |
| Sadée, W | 1 |
| Leyva, A; Pinedo, HM; Schornagel, JH | 1 |
| Carson, DA; Kamatani, N; Nelson-Rees, WA | 1 |
| Brennan, MF; Devereux, DF; Shamberger, RC | 1 |
| Evans, AE | 2 |
| Body, JJ; Kenis, Y; Rozencweig, M | 1 |
| Tschiersch, B | 1 |
| Benz, C; Cadman, E; Silverberg, M | 1 |
| Kamen, BA; Krakower, GR | 1 |
| Sakurai, Y | 1 |
| Boublil, JL; Lalanne, CM; Milano, G; Namer, M; Renee, N; Schneider, M; Thyss, A | 1 |
| Mittiga, S; Rubaltelli, FF; Solito, P | 1 |
| Blain, E; Clare, MG; Taylor, JH | 1 |
| Reich, SD | 2 |
| Fudenberg, HH; Hynes, JB; Tsang, KY | 1 |
| Bast, RC; Blum, RH; Canellos, GP; Frei, E; Garnick, MB; Henderson, IC; Kirkwood, JM; Mayer, RJ; Parker, LM; Pitman, SW; Skarin, AT | 1 |
| Orzechowska-Juzwenko, K | 1 |
| Sauer, H; Schalhorn, A; Wilmanns, W | 1 |
| Chu, BB; Howell, SB; Mendelsohn, J; Metha, BM; Wung, WE | 1 |
| Agostara, B; Di Girolamo, G; Paparopoli, G | 1 |
| Armand, JP | 1 |
| Kang, SH; Wang, YX; Zhang, NF; Zhang, QF; Zhang, XL | 1 |
| Langone, JJ | 1 |
| Calabresi, P; Cummings, FJ; Doolittle, CH; Kaplan, HG; Spremulli, EN; Wiemann, MC | 1 |
| Bruno, S; Creaven, P; Grindey, G; Kinahan, J; Ledesma, E; Mittelman, A; Moayeri, H; Priore, R; Zakrzewski, S | 1 |
| Martin, DS; Nayak, R; Sawyer, RC; Spiegelman, S; Stolfi, RL; Woodcock, T; Young, CW | 1 |
| Camplejohn, RS | 1 |
| Diehl, V; Engelhardt, P; Oellerich, M; Schaadt, M | 1 |
| Anderson, WM; Bleyer, WA; Izutsu, KT; Rice, JC; Schubert, MM; Truelove, EL | 1 |
| Moran, RG; Siegel, SE | 1 |
| Berry, RJ | 2 |
| Diehl, V | 1 |
| Mikulecky, DC; White, JC | 1 |
| McCormack, JJ | 1 |
| Kamel, RS; Landon, J | 1 |
| Donehower, RC; Erlichman, C; Myers, CE | 1 |
| Riley, JH; Riley, MG | 1 |
| Henderson, GB; Huennekens, FM; Suresh, MR; Vitols, KS | 1 |
| Boiron, M; Gisselbrecht, C; Lokiec, F; Marty, M; Najean, Y; Poirier, O | 1 |
| Lankelma, J; Ramaekers, F; van der Klein, E | 1 |
| Liter, ME | 1 |
| Schilsky, RL | 2 |
| Bombardieri, E; Buraggi, GL; Cozzi, A; Raimondo, S | 1 |
| Howell, SB; Tamerius, RK | 1 |
| Yunis, JJ | 1 |
| Varshavsky, A | 1 |
| Lokiec, F; Pommier, Y | 1 |
| Doroshow, JH; Gaasterland, DE; Hubbard, SP; Locker, GY; Myers, CE; Young, RC | 1 |
| Kim, SH; Patterson, AJ; Ritschel, WA; Zellner, D | 1 |
| Hida, K; Kano, Y; Kubota, T; Sakamoto, S; Sakuraya, K; Suda, K; Takaku, F | 1 |
| Banfi, L; Garelli, S; Schieppati, G; Valbonesi, M | 1 |
| Calvert, AH; Turnbull, CP | 1 |
| Lawrence, JR; McNeill, CA; Steele, WH; Stuart, JF | 1 |
| Meyer, RL; Shehata, WM | 1 |
| Lawrence, JR; McNeill, CA; McVie, JG; Steele, WH; Stuart, JF; Whiting, B | 1 |
| Roach, M; Turnbull, C | 1 |
| Fernbach, B; Holland, JF; Ohnuma, T; Takahashi, I | 1 |
| Elisseyeff, Y; Goker, E; Guarino, L; Kheradpour, A; Meyers, PA; Tan, CT; Tong, WP; Trippett, T; VanSyckle, KM; Wollner, N | 1 |
| Antman, K; Ayash, L; Elias, AD; Frei, E; Mazanet, R; Schnipper, L; Schwartz, G; Tepler, I; Wheeler, C | 1 |
| Gabizon, AA; Gorodetsky, R; Mou, X; Vexler, AM | 1 |
| Debord, J; Lachatre, G; Marquet, P; Merle, L; Roullet, B; Sabot, C | 1 |
| Hahn, PJ | 1 |
| Machover, D | 1 |
| Bout, M; Brémond, JL; Dayan, A; Delain, M; Domenech, J; Gihana, E; Linassier, C; Petit, A; Petitdidier, C; Truglio, D | 1 |
| Bustamante, A; Henderson, GB; Patel, R; Rideout, DC | 1 |
| Huennekens, FM | 1 |
| Butler, RW; Finlay, JL; Hill, JM; Meyers, PA; Steinherz, PG | 1 |
| Flynn, G; McHale, AP; McHale, L | 1 |
| Milano, GA; Peters, GJ; Schornagel, JH | 1 |
| Burton, G; Ciociola, AA; Cubeddu, LX; Galvin, D; Meshad, M; Pendergrass, K; Ryan, T; York, M | 1 |
| Caspi, D; Tishler, M; Yaron, M | 1 |
| Borsi, JD; Koós, R; Kovács, GT; Paál, C; Schuler, D; Somló, P | 1 |
| Adams, MJ; Noonan, PK; O'Donnell, JP; Riggs, CE; Teresi, ME; Webster, PM | 1 |
| Dibble, SL; Dodd, MJ | 1 |
| Colofiore, J; Kemeny, N; Martin, D; Sawyer, R; Schneider, A; Seiter, K; Williams, L | 1 |
| Grunberg, SM | 1 |
| Beare, S; Steward, WP | 1 |
| Bhattacharya, B; Malhotra, S; Marwaha, RK; Pershad, D | 1 |
| Bamberger, U; Boven, E; Feller, N; Jansen, WJ; Pinedo, HM; van der Wilt, CL | 1 |
| Chabner, BA; Treon, SP | 1 |
| White, RM | 2 |
| Finn, J; Jones, M; Symmons, D; Wolfe, F | 1 |
| Altman, DG; Parmar, MK; Stewart, LA | 1 |
| Blumenkopf, TA; Cory, M; Elwell, L; Laethem, RM; Moxham, CP; Ray, PH; Smith, GK; Walton, LM | 1 |
| Falk, PM; Kagan, AR; Kogut, N; Morgan, TL; Shah, KH; Tome, M | 1 |
| Avalos, B; Biggs, J; Brodsky, I; Copelan, E; Crilley, P; Downs, K; Marks, DI; Moul, J; Penza, S; Sabol, P; Styler, MJ; Szer, J; Topolsky, D | 1 |
| Banerjee, D; Bertino, JR; Ercikan-Abali, E; Fan, J; Goker, E; Gorlick, R; Hochhauser, D; Li, WW; Schnieders, B; Waltham, M | 1 |
| Hum, MC; Kamen, BA | 1 |
| Bertino, J; Casper, E; Christman, K; Colofiore, J; Kelsen, D; Martin, DS; Quan, V; Saltz, L; Schwartz, GK | 1 |
| DuBose, TD; Jaffe, N; Johansen, MJ; Madden, T; Molony, DA; Wall, SM | 1 |
| Fujimoto, T | 1 |
| Bologna, C; Jorgensen, C; Picot, MC; Sany, J; Verdier, R; Viu, P | 1 |
| Fossella, FV; Hong, WK; Huber, MH; Lee, JS; Lippman, SM; Newman, RA; Wester, M | 1 |
| Inaba, M | 1 |
| Jenks, S | 1 |
| Cheng, CC; Connolly, T; Cowan, KH; Moscow, JA; Myers, TG; Paull, K | 1 |
| Beck, TM; Chang, A; Griffin, D; Harvey, WH; Meshad, M; Navari, R; Wentz, A; York, M | 1 |
| Bottiglieri, T; Farrow, A; Griener, JC; Hyland, K; Kamen, BA; Quinn, CT | 1 |
| Bekesi, JG; Holland, JF; Jiang, J; Roboz, J | 1 |
| Cash, JM; Kanik, KS | 1 |
| Finley, SM; Hobbie, WL; Hollen, PJ | 1 |
| Gooley, T; Hackman, RC; Ko, CW; Lee, SP; McDonald, GB; Myerson, D; Sale, GE; Schoch, HG; Shulman, HM | 1 |
| Evans, WE; Hon, YY | 1 |
| Akerley, W; Calabresi, P; Cole, BF; Egorin, MJ; Glantz, MJ; Hochberg, F; Mills, P; Recht, L; Saris, S | 1 |
| Kinsella, AR; Smith, D | 1 |
| Kremer, JM | 1 |
| Aschan, J; Carlens, S; Hägglund, H; Klaesson, S; Ljungman, P; Lönnqvist, B; Mattsson, J; Remberger, M; Ringdén, O; Svahn, BM; Winiarski, J | 1 |
| Bertino, JR; Trippett, TM | 1 |
| Lennard, L | 2 |
| Edler, L; Fiebig, HH; Frei, E; Hartung, G; Heeger, S; Heene, DL; Kränzle, M; Maier-Borst, W; Queisser, W; Schrenk, HH; Sinn, H; Stehle, G; Wunder, A | 1 |
| Aghi, M; Breakefield, XO; Kramm, CM | 1 |
| Kvinnsland, S | 1 |
| Goodsell, DS | 1 |
| Babin-Boilletot, A; Brunat-Mentigny, M; Kalifa, C; Mahmoud, HH; Pacquement, H; Schmitt, C; Tabone, MD; Terrier, P | 1 |
| Chamberlain, MC; Cole, BF; Glantz, MJ; Howell, SB; Jaeckle, KA; LaFollette, S; Maria, B; Phuphanich, S; Recht, L; Schumann, GB; Swinnen, LJ | 1 |
| Loos, WJ; Nooter, K; Sparreboom, A; Stoter, G; Verweij, J | 1 |
| Bertram, J; Beyer-Sehlmeyer, G; Hiddemann, W; Wörmann, B | 1 |
| Bertz, H; Engelhardt, M; Finke, J; Hahn, J; Holler, E; Kunzmann, R; Reisser, S; Veelken, H; Wäsch, R | 1 |
| Cole, PD; Kamen, BA | 1 |
| Schröder, F; Schroeder, JO | 1 |
| Akutsu, M; Furukawa, Y; Honma, Y; Kano, Y; Mano, H; Sato, Y; Tsunoda, S | 1 |
| Blume, KG; Chauncey, T; Feinstein, L; Flowers, C; Georges, G; Kiem, HP; Little, MT; Maloney, D; Maris, M; McSweeney, PA; Nash, RA; Niederwieser, D; Radich, J; Sandmaier, B; Shizuru, J; Storb, R; Woolfrey, A; Zaucha, JM | 1 |
| Chan, GZ; Kapoor, M | 1 |
| de Wit, R; Loos, WJ; Louwerens, M; Smorenburg, C; Sparreboom, A; Verweij, J | 1 |
| Aschan, J; Barkholt, L; Hentschke, P; Ljungman, P; Mattsson, J; Remberger, M; Ringdén, O | 1 |
| Brant, J; Nielsen, E | 1 |
| Hachulla, E | 1 |
| Celik, I; Guc, D; Kars, A; Ruacan, S; Tekuzman, G | 1 |
| Ben Maïz, H; Ben Taarit, C; Turki, S | 1 |
| Banerjee, D; Bertino, JR; Budak-Alpdogan, T; Capiaux, G; Gorlick, R; Mayer-Kuckuk, P | 1 |
| Chan, H; Evans, WE; Pratt, CB | 1 |
| Calvert, AH; Hill, BT; Hughes, KB; Price, LA; Shaw, HJ | 1 |
| DeWys, WD | 1 |
| Salem, PA | 1 |
| Frei, E; Krishan, A; Paika, KD; Pitman, SW; Smith, DC; Tattersall, HN | 1 |
| Engelhardt, P | 1 |
| Kühböck, S | 1 |
| Barranco, S; Costanzi, JJ; Gagliano, RG; Griffiths, C; Loukas, D | 1 |
| Tattersall, MH; Tobias, JS | 1 |
| Hellmann, K; Hill, BT | 1 |
| Schein, PS; Winokur, SH | 1 |
| Chabner, BA; Myers, CE; Oliverio, VT | 1 |
| Carter, SB; Friedman, MA | 1 |
| Berry, RJ; Bryan, G | 1 |
| Jehn, U; Kohlschütter, B | 1 |
| Willson, JK | 1 |
| Chabner, BA; Coleman, CN; Johns, DG; Myers, CE | 1 |
| Garnick, MB; Mayer, RJ | 1 |
| Burchenal, JH | 1 |
| Oberfield, RA | 2 |
| Rosenberg, SA | 1 |
| Livingston, RB | 1 |
| Sullivan, MP; Sutow, WW | 1 |
| Allen, JC | 1 |
| Einhorn, LH | 1 |
| Holland, JF; Silver, RT; Young, RC | 1 |
| Louie, AC; Muggia, FM; Rozencweig, M; von Hoff, DD | 1 |
| Bell, R; Hurley, TH; Moon, WJ; Sullivan, JR | 1 |
| Baumgartner, G; Heinz, R; Karrer, K; Lutz, D; Pridun, N | 1 |
| Helman, LJ; Penta, JS; Slavik, M; Von Hoff, DD | 1 |
| Gisolfi, AL; Mehta, BM; Mosende, C; Nirenberg, A; Rosen, G | 1 |
| Chabner, BA; Hande, KR; Jacobs, SA; Rosenberg, SA; Stoller, RG | 1 |
| Carmody, J; Howell, SB | 1 |
| Bender, RA; Louie, AC; Muggia, FM; Rozencweig, M; Von Hoff, DD | 1 |
| Akahoshi, M | 1 |
| Nirenberg, A; Rosen, G | 1 |
| Frei, E; Howell, SB; Krishan, A | 1 |
| Calabresi, P; Cummings, FJ; Kaplan, HG; Stoller, RG | 1 |
| Ambinder, EP; Biller, HF; Holland, JF; Ohnuma, T; Perloff, M | 1 |
| Gnarra, D; Goh, TS; Lampkin, B; O'Leary, J; Wong, KY | 1 |
| Cocconi, G; Mori, P; Salvadori, C; Tedeschi, R | 1 |
| Lu, L; Song, SZ; Sun, Y; Wang, QL; Ye, ZS; Zhou, JC | 1 |
| Breyer, S; Graninger, W; Jaschek, I; Lenzhofer, R; Moser, K | 1 |
| Haskell, CM | 1 |
| Sieber, SM | 1 |
| Grindey, GB; Mihich, E | 1 |
| Costanzi, J; Lane, M; Lehane, DE; Padilla, F; Tranum, B | 1 |
| Bleyer, WA | 4 |
| Bender, JF; Fortner, CL; Grove, WR | 1 |
| Tanneberger, S | 1 |
| Goldin, A | 3 |
| Harrap, KR; Jackson, RC | 1 |
| Jacobs, SA; Santicky, MJ | 1 |
| Sweet, DL; Ultmann, JE | 1 |
| Block, JB; Cone, L; Dollinger, M; Eilber, F; Isacoff, WH; Klein, P; Lemkin, S; Rosenbloom, B; Sheehy, P; Sieger, L; Tabbarah, H | 1 |
| Harding, NG; Shanks, GF; Simmonds, AP; Whiteley, JM | 1 |
| Ensminger, WD; Frei, E; Glode, LM; Papathanasopoulos, N; Pitman, SW; Rosowsky, A | 1 |
| Harrap, KR | 1 |
| Paxton, JW | 1 |
| Cunningham, T; Donavan, M; Longacre, D; Paladine, W; Sponzo, R | 1 |
| Christophidis, N; Louis, WJ; Lucas, I; Moon, WJ; Vajda, FJ | 1 |
| Hughes, LE; Jones, KD | 1 |
| Howell, SB; Olshen, RA; Rice, JA | 1 |
| Calman, KC; Lawrence, JR; McNeill, CA; McVie, JG; Sneader, WE; Steele, WH; Stuart, JF; Whiting, B | 1 |
| Calman, KC; Lawrence, JR; McVie, JG; Paxton, J; Steele, WH; Stuart, JF; Watters, J; Whiting, B | 1 |
| Derr, CJ; Jacobs, SA; Johns, DG | 1 |
| Bender, RA; Warren, RD | 1 |
| Bishun, NP; Reed, J; Williams, D | 1 |
| Ensminger, WD; Frei, E; Howell, SB; Krishan, A | 1 |
| Evans, WE; Taylor, RH | 1 |
| Senn, HJ | 1 |
| Gratwohl, AA | 1 |
| Mazloumi, B; Missmahl, HP; Weber, W | 1 |
| Catane, H; Catane, R | 1 |
| Balint, G; Buchanan, WW; de Ceulaer, K; Dick, WC; El-Ghobarey, A; Hadidi, T; Hassan, TA | 1 |
| Bayssas, M; Dantchev, D; Delgado, M; DeVassal, F; Gil, MA; Gouveia, J; Hayat, M; Machover, D; Mathé, G; Misset, JL; Ribaud, P; Slioussartchouk, V | 1 |
| Bonmassar, E; Goldin, A; Nicolin, A | 1 |
| Jaffe, N | 2 |
| Calabresi, P; Heppner, GH | 1 |
| Puff, KH | 1 |
| Berry, RJ; Laing, AH; Wells, J | 1 |
| Dubois, JB; Serrou, B | 1 |
| Domellöf, L | 1 |
| Balcerzak, SP; Bearden, JD; Coltman, CA; Costanzi, JJ; Lane, M; Moon, TE; Morrison, FS; Rivkin, SE; Saiki, JH; Spigel, SC | 1 |
| Ensminger, WD; Frei, E | 1 |
| Bech-Hansen, NT; Ling, V; Sarangi, F; Sutherland, DJ | 1 |
| de Costa, M; Iqbal, MP; Rothenberg, SP | 1 |
| Carter, DC; Jamieson, GG | 1 |
| Balow, JE; Chabner, BA; Drake, JC; Hande, KR; Rosenberg, SA | 1 |
| Smolyanskaya, AZ | 1 |
| Bergstresser, PR; Schreiber, SH; Weinstein, GD | 1 |
| Bertino, JR; Cashmore, AR; Sawicki, WL; Skeel, RT | 1 |
| Clarke, C; Wills, ED | 1 |
| Barthel, E; Felsch, G; Siering, H | 1 |
| Baumgartner, G | 2 |
| Siebner, H; Weber, W | 1 |
| Hunstein, W; Rehn, K | 1 |
| Bailin, PL; Hogan, MD; Roenigk, HH; Tindall, JP | 1 |
| Bender, RA; Makulu, DR | 1 |
| Frei, E; Jaffe, N; Parker, L; Pitman, S; Tattersall, MH | 1 |
| Holm, O | 1 |
| Block, JB; Eiber, FR; Forster, T; Isacoff, WH; Morton, DL; Townsend, CM | 1 |
| Begemann, H; Theml, H; Winnewisser, M | 1 |
| Focan, C | 1 |
| Armstrong, DM; Aust, JB; Cruz, AB; Dowell, KE | 1 |
| Rosenfelt, F | 1 |
| Cohen, HJ; Hauch, TW; Kremer, WB; Mason, D; Shelbourne, JD | 1 |
| Friedman, M | 1 |
| Bornstein, RS; Engstrom, PF; Freeman-Narrod, M; Gerstley, BJ | 1 |
| Krakoff, IH; Old, LJ | 1 |
| Zachariae, H | 1 |
| Bando, H; Nakamura, Y; Saito, S; Shintani, Y; Yokogoshi, Y | 1 |
| Schmoll, HJ | 1 |
| Ringdén, O | 1 |
| Abrams, SM; Caulfield, M; Heybroek, W; Lawson, M; Raveendran, R; Slevin, M; Turner, P; Wrigley, PF | 1 |
| Weiss, RB | 1 |
| Eisenlohr, H; Lydtin, H; Prechtel, K; Trenkwalder, P | 1 |
| Chen, AP; Grem, JL | 1 |
| Graczyk, J | 1 |
| Abrams, SM; Caulfield, M; Heybroek, WM; Raveendran, R; Slevin, M; Turner, P; Wrigley, PF | 1 |
| Crist, WM; Crom, WR; Evans, WE; Groom, S; McLeod, HL; Relling, MV; Rivera, GK; Rodman, JH; Silverstein, K | 1 |
| Eden, OB; Elton, R; Shaw, NJ | 1 |
| Narasimha, K | 1 |
| Barr-Nea, L; Sandovsky-Losica, H; Segal, E | 1 |
| Nakamura, T; Uchida, M; Ueda, T | 1 |
| Klaesson, S; Ljungman, P; Lönnqvist, B; Persson, U; Ringdén, O; Sundberg, B | 1 |
| Adamyan, A; Gumargalieva, K; Horák, D; Skuba, N; Svec, F; Titova, M; Trostenyuk, N; Vishnevskii, V; Voronkova, O | 1 |
| Bertrand, Y; Etienne, MC; Milano, G; Robert, A; Rubie, H; Thyss, A; Touraine, R | 1 |
| Buscema, J; Currie, JL; McLellan, R; Woodruff, JD | 1 |
| Exelby, P; Ghavimi, F; Luks, E; Wachtel, A; Wollner, N; Woodruff, J | 1 |
| Aschele, C; Bertino, JR; Fanin, R; Lin, JT; Trippett, TM; Volkendandt, M | 1 |
| Gaspard, MH; Milano, G; Montagne, N; Schneider, M; Thyss, A | 1 |
| Allegra, CJ; Chabner, BA; Chu, E; Grem, JL; Johnson, P; Yeh, GC | 1 |
| Vogelzang, NJ | 1 |
| Gazdar, AF; Kramer, BS; Perng, RP; Tsai, CM | 1 |
| Christensen, B; Djurhuus, R; Refsum, H; Ueland, PM | 1 |
| Daniel, B; Ding, RW; Herrmann, R; Port, RE | 1 |
| Dorr, RT | 1 |
| Mai, M; Ogino, T; Suga, T; Takahashi, Y | 1 |
| Melera, PW | 1 |
| Meurman, JH; Pyrhönen, S; Torkko, H | 1 |
| Borst, P | 1 |
| Cahill, R; Cottler-Fox, M; Deeg, HJ; Pickle, LW; Spitzer, TR | 1 |
| Bertino, JR; Romanini, A | 1 |
| Schrøder, H | 1 |
| Fischetti, LF | 1 |
| Borsi, JD; Moe, PJ; Romslo, I; Sagen, E | 1 |
| Bourdeaux, M; Briand, C; Chauvet, M; Rimet, O; Sastre, B | 1 |
| Herrmann, R | 2 |
| Atkinson, CH; Colls, BM; Fitzharris, BM; Frampton, CM; Robinson, BA | 1 |
| Andersson, BS; Dreizen, S; Keating, MJ; McCredie, KB | 1 |
| Broto Escapa, P; Casaldáliga Ferrer, J; Escribano Subías, J; Moraga Llop, FA; Sánchez de Toledo Codina, J; Sanz Manrique, N; Valcarce Pérez, J | 1 |
| Kemeny, NE; Martin, DS; Schneider, A | 1 |
| Goldman, ID; Matherly, LH | 2 |
| Ogawa, M | 1 |
| Morita, K | 1 |
| Bagshawe, KD; Begent, RH; Crawford, SM; Ledermann, JA; Newlands, ES; Rustin, GJ; Turkie, W | 1 |
| Capizzi, RL; Coln, D; Craig, J; Kamen, BA; McGuirt, F; Sklar, F; Streckfuss, A; Winick, NJ | 1 |
| Asamura, M; Ishikawa, A; Ishioka, C; Kakuta, H; Kanamaru, R; Konishi, Y; Sato, T; Wakui, A | 1 |
| Ogino, T; Takita, T | 1 |
| Brunet, P; Cano, JP; Carcassonne, Y; Imbert, AM; Lena, N | 1 |
| Jolivet, J | 1 |
| McIntosh-Lowe, NL; Rose, CM; Teicher, BA | 1 |
| Clarkson, B; Fain, K; Gabrilove, JL; Grous, J; Jakubowski, A; Moore, MA; Scher, H; Sternberg, C; Wong, G; Yagoda, A | 1 |
| Balińska, M | 1 |
| Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Wang, QL | 1 |
| Diddens, H; Frese, G; Gekeler, V; Handgretinger, R; Henze, G; Niethammer, D; Probst, H; Schmidt, H | 1 |
| Bertino, JR; Chang, YM; Li, WW; Lin, J; Pizzorno, G | 1 |
| Higano, CS; Livingston, RB | 1 |
| Amer, M; el-Yazigi, A; Martin, CR | 1 |
| Baumelou, A; Bourbouze, R; Cacoub, P; Deray, G; Jacobs, C; Jacquillat, C; Khayat, D; Musset, L | 1 |
| Hattori, T; Jinushi, K; Kim, R; Niimoto, M; Saeki, K; Saeki, T; Toi, M; Yanagawa, E; Yoshinaka, K | 1 |
| Clements, PJ; Davis, J | 1 |
| Jani, JJ; Luscombe, DK; Yap, AK | 1 |
| Anderson, N; Beauchamp, K; Bern, M; Lokich, J; Moore, C; Wallach, S; Williams, D | 1 |
| Alberti, D; Bruggink, J; Fischer, PH; Grem, JL; Nieting, L; Remick, SC; Trump, DL; Tutsch, KD; Willson, JK | 1 |
| Lönn, S; Lönn, U | 1 |
| Barni, S; Crispino, S; Esposti, D; Esposti, G; Ferri, L; Fumagalli, G; Lissoni, P; Paolorossi, F; Rovelli, F; Tancini, G | 1 |
| Kanellos, J; McKenzie, IF; Pietersz, GA | 1 |
| Huennekens, FM; Kuefner, U; Lohrmann, U; Montejano, Y; Vitols, KS | 1 |
| Davis, RE | 1 |
| Britsch, B; Herrmann, R; Hull, WE; Kunz, W; Port, RE | 1 |
| Bode, U; Erps, M; Schiffer, D | 1 |
| Kairis, M; Mousatos, G; Pappas, J; Prodromou, N; Tzortzatou-Stathopoulou, F; Zavitsa-Pateli, H | 1 |
| Gutteberg, TJ; Kolmannskog, S; Slørdal, L | 1 |
| Cortese, P; De Fabiani, E; Giai, M; Giardina, G; Lamberto, A | 1 |
| Frahm, H; von Hülst, M | 1 |
| Donehower, RC; Ettinger, DS; Grochow, LB; Hantel, A; McGuire, WP; Noe, DA; Rowinsky, EK; Vito, BL | 1 |
| Kiyohara, T; Koga, S; Kubota, S; Saitoh, Y; Sakuragi, T; Taniguchi, K | 1 |
| Raymond, CA | 1 |
| Feng, FY; Lu, L; Song, SZ; Sun, Y; Wang, QL; Yie, ZS; Zhou, JC | 1 |
| Hellthaler, G; Krause, G; Krauss, J | 1 |
| Hoth, DF; King, SA; Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Henner, WD | 1 |
| Jukes, TH | 1 |
| Ackland, SP; Schilsky, RL | 1 |
| Cowan, K; Ozols, RF | 1 |
| Gillman, MA | 1 |
| al-Turk, A; Awidi, A; Madanat, F; Othman, S; Shaheen, O | 1 |
| Kamen, BA; Winick, NJ | 1 |
| Cohen, P; Dix, D | 1 |
| Meadows, AT; Packer, RJ; Rorke, LB; Wizniter, M | 1 |
| Hoth, DF; Leyland-Jones, B; O'Dwyer, PJ; Wittes, RE | 1 |
| Kvinnsland, S; Refsum, H; Ueland, PM; Wesenberg, F | 1 |
| Farid, YY; Skellern, GG; Stewart, MJ; Watson, ID | 1 |
| Cano, JP; Fabre, G; Payet, B; Tubiana, N | 1 |
| Baldwin, RW; Ballantyne, KD; Caten, JE; Clegg, JA; Garnett, MC; Perkins, AC; Pimm, MV | 1 |
| Lampkin, BC; Wong, KY | 1 |
| Fry, DW; Jackson, RC | 1 |
| Furue, H | 2 |
| Ambaye, RY; Gokhale, SV; Kumar, RV; Shetty, PA | 1 |
| Losonczy, H; Nagy, I | 1 |
| Akazawa, S | 1 |
| Maynard, K; Parsons, PG | 1 |
| Al-Saleh, I; Amer, M; el-Yazigi, A; Martin, C | 1 |
| Dedhar, S; Goldie, JH; Hill, BT; Whelan, RD | 1 |
| Baumgartner, G; Baumgartner, M | 1 |
| Wakui, A | 1 |
| Neilan, BA | 1 |
| Takaku, F | 1 |
| Erttmann, R; Gkanatsas, A | 1 |
| Fujimoto, T; Matuoka, H; Murakami, T; Sasaki, K; Taguchi, H; Tanaka, J | 1 |
| Beschorner, WE; Clark, AW; Patchell, RA; Santos, GW; White, CL | 1 |
| Sirotnak, FM | 1 |
| Lilly, MB; Omura, GA | 1 |
| Nashel, DJ | 1 |
| Baldwin, RW | 1 |
| Patchell, RA; Posner, JB | 1 |
| Furst, DE | 1 |
| Weinblatt, ME | 1 |
| Bertino, JR; Carmen, M; Dube, S; Jastreboff, M; Love, T; Mini, E; Moroson, BA; Sobrero, A; Srimatkandada, S | 1 |
| Iqbal, MP; Rothenberg, SP | 1 |
| Iqbal, MP | 1 |
| Hazleman, B | 1 |
| Friedlander, ML; Slowiaczek, P; Tattersall, MH; Taylor, IW | 1 |
| Hill, A; Johnston, RN; Schimke, RT | 1 |
| Moccio, DM; Samuels, LL; Sirotnak, FM | 1 |
| Kamiya, H; Kawasaki, H; Nobori, T; Sakurai, M | 1 |
| Benz, C; Cadman, E; DeGregorio, M; Holleran, W; Ignoffo, R; Lewis, B; Saks, S; Sambol, N | 1 |
| Alonso, MT; Eisenberger, M; Hoth, DF; Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Curt, G; Lokich, JJ | 1 |
| Curt, G; Green, R; Lokich, JJ; Paul, S; Phillips, D; Sonneborn, H; Zipoli, TE | 1 |
| Oosterbaan, MJ; Termond, EF; Van der Kleijn, E; Vree, TB; Winograd, B; Zonnenberg, B | 1 |
| Abelson, HT; Dolnick, BJ; Kamen, BA; Nylen, PA; Peterson, DW; Whitehead, VM | 1 |
| Bruno, R; Cano, JP; Favre, R; Iliadis, A; Imbert, AM; Lena, N | 1 |
| Rubaltelli, FF; Varagnolo, P; Viozzi, A | 1 |
| Sullivan, RD | 1 |
| Cappelaere, P | 1 |
| Hartwich, G | 1 |
| Colon, J; Mayer, M | 1 |
| Donegan, WL; Harris, HS | 1 |
| Hartwich, G; Soyka, D; Taghavy, A | 1 |
| Gary-Bobo, J | 1 |
| Shaw, HJ | 1 |
| Stephens, FO | 2 |
| Chauvergne, J; Durand, M; Hoerni, B; Mothey, C | 1 |
| Brescia, T; Goldin, A; Ikawa, Y; Johnson, RK | 1 |
| Goerttler, K; Kaufmann, M; Mattern, J; Volm, M; Wayss, K | 1 |
| Sindram, PJ; Snow, GB | 1 |
| Simmonds, WP | 1 |
| Rubens, RD | 1 |
| Rikhe, K | 1 |
| Rieche, K; Wand, H | 2 |
| Mattern, J; Volm, M; Wayss, K | 1 |
| Abendroth, K; Siering, VH | 1 |
| Livio, JJ; Pettavel, J | 1 |
| Brown, B; Hall, TC; Maddock, C; Nathanson, L | 1 |
| Bean, RH; Traill, M | 1 |
| Bodansky, O; Nisselbaum, JS; Schwartz, MK | 1 |
| Wüst, GP | 1 |
| Cunningham, TJ; Horton, J; Laffin, R; Olson, KB; Sullivan, J | 1 |
| Casale, C; Cortese, M; Nervi, C | 3 |
| Watne, AL | 1 |
| Bodey, GP; Goldschmidt, MC | 1 |
| Andreesu, M; Matefsu, C; Mogos, I; Mudric, V | 1 |
| Mellett, LB | 1 |
| Dendy, PP | 1 |
| Charachon, R; Piaget, F | 1 |
| Hansen, HH; Holland, JF; McCall, CB; Selawry, OS | 1 |
| Booth, JC; Cady, B; Oberfield, RA | 1 |
| Ti, TK; Yong, NK | 1 |
| Bertino, JR; DeConti, RC; Kaplan, SR; Mitchell, MS; Papac, R; Wawro, NW | 1 |
| Watt, J | 1 |
| Egli, F; Stald, G | 1 |
| Bergsagel, DE | 1 |
| Miller, RW | 1 |
| Foley, JF; Lemon, HM; Miller, D | 1 |
| Depierre, A; Israel, L | 1 |
| Vermund, H | 1 |
| Freeman, JE; Malpas, JS | 1 |
| Bertino, JR; Cashmore, AR; Hillcoat, BL | 1 |
| Azarnoff, DL; Hoogstraten, B; Huffman, DH; Stephens, R; Wan, SH | 1 |
| Ceci, A; Mitolo-chieppa, D | 1 |
| Galt, RM; Knock, FE; Oester, YT; Sylvester, R | 1 |
| Chisholm, M | 1 |
| Mathe, G; Pouillart, P; Schwarzenberg, L | 1 |
| Crowther, D | 1 |
| Conroy, JF | 1 |
| Beauduin, M; Deckers, C; Longueville, J; Maisin, H; Wambersie, A | 1 |
| Pratt, CB; Roberts, D; Shanks, EC; Warmath, EL | 1 |
| Levine, L; Powers, E | 1 |
| Newbold, PC | 1 |
| Barranco, VP | 1 |
| Freckman, HA | 1 |
| Braun, HJ | 1 |
| Kühböck, J | 1 |
| Tattersall, MH | 1 |
| Rivlin, RS | 1 |
| Cole, D; Glenn, EH; Wunderlich, HO | 1 |
| Klaassen, DJ | 1 |
| Arseneau, JC; Canellos, GP; DeVita, VT; Sherins, RJ | 1 |
| Hall, TC | 1 |
| Hackethal, L; Siebner, H | 1 |
| Helman, P; Sealy, R | 1 |
| Hill, GJ; Larsen, RR | 1 |
| Greenwald, ES | 1 |
| Goldenson, Y; Lev, L; Robinson, E | 1 |
| Kühböck, J; Kummer, F | 1 |
| Cohen, SM; Greenspan, EM; Weiner, MJ | 1 |
| Imaizumi, M | 1 |
| Nelson, GH | 1 |
| Edlis, H; Herbert, V; Tisman, G | 1 |
| Bagai, RC; Harris, JE; Stewart, TH | 1 |
| Omura, GA; Roberts, GA | 1 |
| Priestman, TJ | 1 |
| Braun-Falco, O; Christophers, E; Plewig, G | 1 |
| Gerner, RE; Moore, GE | 1 |
| Dorschner, W; Gläser, A; Paschke, P; Schönfelder, M | 1 |
| Castor, H; Drings, P; Fritsch, H; Moskwa, G | 1 |
| Damascelli, B; De Palo, GM; Di Pietro, S; Gennari, L; Molinari, R | 1 |
| Armata, J; Cyklis, R; Legutko, L | 1 |
| Mohr, A; Tanneberger, S | 1 |
| Ajayi, OO; Khwaja, MS; Ngu, VA; Osunkoya, BO | 1 |
| Kiehn, C; Mandel, MA | 1 |
| Cooper, EH | 1 |
| Weir, DG | 1 |
| Berndt, H; Rieche, K | 1 |
| Chlud, K | 1 |
| Dayton, PG; Kinkade, JM; Vogler, WR | 1 |
| Hauschka, TS; Holdridge, BA | 1 |
| Sokal, JE; Stutzman, L | 1 |
| Alberto, P | 1 |
| Bertino, JR; Calabresi, P; DeConti, RC; Mitchell, MS; Wade, ME | 1 |
| van Os, FH | 1 |
| Vermel', EM | 1 |
| Chahinian, P; Depierre, A; Israel, L | 1 |
| Shetty, PA | 1 |
| Wilmanns, W | 1 |
| Frei, E; Goldin, A; Henderson, ES; Holland, JF; Newman, JW; Sandberg, JS | 1 |
| Block, JB; Carbone, PP; Haskell, CM; Leventhal, BG; Selawry, OS | 1 |
| Heckmann, U | 1 |
| Kadlecová, D; Konecný, M; Mechl, Z; Uchytil, B | 1 |
| Clément, F | 1 |
| Johnson, RH; Ketcham, AS; Mullins, FX; Perry, S; Schwartz, SA | 1 |
| Hitchings, GH | 1 |
| Crumbley, AJ; Grady, CK; Grady, ED; Nolan, TR | 1 |
| Couture, J; Deschênes, L | 1 |
| Lamerton, LF | 1 |
| Benson, JW | 1 |
| Jewell, WR | 1 |
| Gulesserian, HP; Lawton, RL; Sharzer, LA | 1 |
| Goldstein, G; Horsley, JS; Lleander, VC | 1 |
| Artz, CP; O'Brien, PH | 1 |
| Kölle, G | 1 |
| Goldie, JH; Harrap, KR; Price, LA | 1 |
| Sims, L | 1 |
| Donaldson, RC | 1 |
| Berstad, T; Liavåg, I; Tamsfoss, S | 1 |
| Goldie, JH; Price, LA | 1 |
| Górkiewicz, A; Kostanecki, W; Mazurkiewicz, W; Zborzil, J | 1 |
| Nathanson, L | 1 |
| Brun, F; Brunner, KW | 1 |
| Hanham, IW; Newton, KA; Westbury, G | 1 |
| Snow, GB | 1 |
| Aoki, Y; Moore, GE | 1 |
| Curtis, AB; Stern, MH | 1 |
| Calnan, J; Davies, A | 1 |
| Barkin, M; Cowan, CR; MacDonald, JA; Mahoney, LJ | 1 |
| Bryon, PA; Dechavanne, M; Fiere, D; Guyon, JM; Revol, L | 1 |
| Byron, RL; Keating, JL; Riihimaki, DU; Yonemoto, RH | 1 |
| Schwarzenberg, L | 1 |
| Jacobs, J; Vogler, WR | 1 |
| Gorgun, B; Watne, AL | 1 |
| Rall, DP | 1 |
| Ishihara, S | 1 |
| Dawson, AA; Ogston, D | 1 |
| Deckers, C; Longueville, J; Maisin, H; Salamon, E; Wambersie, A | 1 |
| Anderson, LL; Collins, GJ; Oberfield, RA; Ojima, Y; Sullivan, RD | 1 |
| Anderson, LL; Collins, GJ; Ojima, Y; Sullivan, RD | 1 |
| Abrahámová, J; Havránková, N; Jakoubková, J | 1 |
| Al-Sarraf, M; Sardesai, S; Vaitkevicius, VK; Wong, P | 1 |
| Ediger, AJ; Mason, JH | 1 |
| Beretta, G; Bonadonna, G; De Lena, M; Fossati-Bellani, F; Monfardini, S | 1 |
| Kadlecová, D; Mechl, Z | 1 |
| Galt, RM; Knock, FE; Oester, YT; Renaud, OV; Sylvester, R | 1 |
| Coltman, CA; Costanzi, JJ; Dudley, GM; Gehan, EA; Haut, A; Lane, M | 1 |
| Healy, JB; Maddock, PG; Moriarty, MJ | 1 |
| Brincker, H | 2 |
| Coninx, P; Lachapelle, F; Pirenne, Y | 1 |
| Chauvergne, J; Hoerni, B; Kressmann, MP; Simon, G | 1 |
| Bachi, C; Cavallero, P; Fazio, M; Sartoris, S; Vergnano, F | 1 |
| Scott, CW | 1 |
| Harris, CC | 1 |
| Craig, SR; Rosenberg, EW | 1 |
| Kramer, S; Mansfield, CM; Southard, ME | 1 |
| Osswald, H | 1 |
| Dederick, MM; Hall, TC; Taft, PD | 1 |
| Dawson, AA; Ogston, D; Philip, JF | 1 |
| Corfield, J; Fowler, JF; Joslin, C; Morrison, R; Twentyman, P; Woolley-Hart, A | 1 |
| Barbier, P; Jacobs, E; Manaster, J; Robert, J | 1 |
| Bertino, JR; Chang, PK; Johns, DG; Spencer, RP | 1 |
| Frattina, A | 1 |
| Smith, GM | 1 |
| Beldotti, L; Schwartz, RS | 1 |
| Carbone, PP; Freireich, EJ; Hersh, EM; Wong, VG | 1 |
| Reboul, J; Rousseau, J; Tessier, JP | 1 |
| Bertino, JR; Hellman, S; Kligerman, MM; Von Essen, CF | 1 |
| Freireich, EJ; Hersh, EM; Wong, VG | 1 |
| Burn, JI; Davies, AJ; Johnston, ID; Sellwood, RA | 1 |
| Hall, TC; Kessel, DH; Roberts, D | 1 |
219 review(s) available for methotrexate and Benign Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction | 2015 |
Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.
Topics: Animals; Antineoplastic Agents; Docetaxel; Drug Resistance, Neoplasm; Humans; Neoplasms; Paclitaxel; Taxoids | 2018 |
Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Gastrointestinal Diseases; Humans; Methotrexate; Neoplasms | 2018 |
Quinolone hybrids and their anti-cancer activities: An overview.
Topics: Animals; Antineoplastic Agents; Humans; Neoplasms; Quinolones; Structure-Activity Relationship | 2019 |
Coumarin-containing hybrids and their anticancer activities.
Topics: Animals; Antineoplastic Agents; Coumarins; Drug Design; Drug Discovery; Humans; Neoplasms; Structure-Activity Relationship | 2019 |
Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options.
Topics: Anti-Infective Agents; Antimalarials; Biological Therapy; Comorbidity; Dermatologic Agents; Diabetes Complications; Diagnosis, Differential; Glucocorticoids; Granuloma Annulare; Humans; Iatrogenic Disease; Infections; Methotrexate; Neoplasms; Pentoxifylline; Phosphodiesterase 4 Inhibitors; Phototherapy; Piperidines; Pyrimidines; Thalidomide | 2022 |
Association between SLCO1B1 polymorphism and methotrexate-induced hepatotoxicity: a systematic review and meta-analysis.
Topics: Alleles; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Humans; Liver-Specific Organic Anion Transporter 1; Methotrexate; Neoplasms; Polymorphism, Genetic; Randomized Controlled Trials as Topic | 2022 |
Late effects of high-dose methotrexate treatment in childhood cancer survivors-a systematic review.
Topics: Antineoplastic Agents; Cancer Survivors; Case-Control Studies; Child; Female; Humans; Long Term Adverse Effects; Male; Methotrexate; Neoplasms | 2022 |
Leucovorin (folinic acid) rescue for high-dose methotrexate: A review.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Leucovorin; Methotrexate; Neoplasms; Renal Dialysis | 2022 |
A comprehensive review on methotrexate containing nanoparticles; an appropriate tool for cancer treatment.
Topics: Arthritis, Rheumatoid; Drug Delivery Systems; Humans; Methotrexate; Nanoparticles; Neoplasms | 2022 |
[DMARD (disease-modifying antirheumatic drug) treatment in patients with former or current cancer].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Humans; Janus Kinase Inhibitors; Methotrexate; Neoplasms | 2023 |
External evaluation and systematic review of population pharmacokinetic models for high-dose methotrexate in cancer patients.
Topics: Bayes Theorem; Computer Simulation; Humans; Methotrexate; Models, Biological; Neoplasms | 2023 |
JAK inhibitors and the risk of malignancy: a meta-analysis across disease indications.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Janus Kinase Inhibitors; Methotrexate; Neoplasms | 2023 |
Glucarpidase (carboxypeptidase G2): Biotechnological production, clinical application as a methotrexate antidote, and placement in targeted cancer therapy.
Topics: Antibodies; Antidotes; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Neoplasms; Polymers; Prodrugs | 2023 |
The role of therapeutic drug monitoring in the management of safety of anticancer agents: a focus on 3 cytotoxics.
Topics: Antineoplastic Agents; Busulfan; Dose-Response Relationship, Drug; Drug Monitoring; Fluorouracil; Humans; Methotrexate; Neoplasms; Practice Guidelines as Topic; Precision Medicine | 2019 |
Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities.
Topics: Antimetabolites, Antineoplastic; Biosynthetic Pathways; Cell Proliferation; Energy Metabolism; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Protein Processing, Post-Translational; Purine Nucleotides; Pyrimidine Nucleotides; S-Adenosylmethionine; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2020 |
[Radiotherapy and immune suppression: A short review].
Topics: Autoimmune Diseases; Female; Genital Neoplasms, Female; Humans; Immunocompromised Host; Immunosuppression Therapy; Immunosuppressive Agents; Male; Methotrexate; Neoplasms; Organs at Risk; Prostatic Neoplasms; Radiotherapy; Transplant Recipients; Transplants; Withholding Treatment | 2020 |
Vitamin D and Other Differentiation-promoting Agents as Neoadjuvants for Photodynamic Therapy of Cancer.
Topics: Administration, Oral; Aminolevulinic Acid; Cell Differentiation; Fluorouracil; Humans; Methotrexate; Neoadjuvant Therapy; Neoplasms; Photochemotherapy; Photosensitizing Agents; Vitamin D | 2020 |
Dose Issues in Cancer Chemotherapy.
Topics: Adolescent; Adult; Animals; Antimetabolites, Antineoplastic; Child; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Neoplasms | 2020 |
Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers.
Topics: Autoimmune Diseases; Folic Acid; Humans; Methotrexate; Neoplasms; Nervous System Diseases; Pharmaceutical Preparations | 2020 |
Potential Benefits and Pitfalls of Histidine Supplementation for Cancer Therapy Enhancement.
Topics: Animals; Dietary Supplements; Folic Acid; Formiminoglutamic Acid; Histidine; Humans; Leukemia; Methotrexate; Neoplasms | 2020 |
Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis.
Topics: Antimetabolites, Antineoplastic; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Neoplasms; Polymorphism, Single Nucleotide | 2021 |
Childhood cancer chemotherapy-induced bone damage: pathobiology and protective effects of resveratrol and other nutraceuticals.
Topics: Antimetabolites, Antineoplastic; Bone Resorption; Cell Differentiation; Child; Dietary Supplements; Humans; Methotrexate; Neoplasms; Protective Agents; Resveratrol; Stilbenes | 2017 |
Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis.
Topics: Child; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Pediatrics; Polymorphism, Single Nucleotide; Risk Factors | 2018 |
Cancer pharmacogenomics in children: research initiatives and progress to date.
Topics: Anthracyclines; Antineoplastic Agents; Child; Cisplatin; Humans; Methotrexate; Neoplasms; Pharmacogenetics; Purines; Vincristine | 2013 |
Challenging the clinical relevance of folinic acid over rescue after high dose methotrexate (HDMTX).
Topics: Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Humans; Leucovorin; Methotrexate; Neoplasms | 2013 |
Methotrexate-induced pneumonitis: heterogeneity of bronchoalveolar lavage and differences between cancer and rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; CD4-CD8 Ratio; Humans; Lung; Lymphocytosis; Methotrexate; Neoplasms; Neutrophils; Pneumonia | 2014 |
The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.
Topics: Aminopterin; Animals; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein | 2014 |
Targeting metabolic changes in cancer: novel therapeutic approaches.
Topics: Antimetabolites, Antineoplastic; Biomarkers, Tumor; DNA-Binding Proteins; Fatty Acids; Glutamine; Humans; Isocitrate Dehydrogenase; Methotrexate; NAD; Neoplasms; Phosphopyruvate Hydratase; Signal Transduction; Tumor Suppressor Proteins | 2014 |
Risk of breast cancer and total malignancies in rheumatoid arthritis patients undergoing TNF-α antagonist therapy: a meta-analysis of randomized control trials.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Certolizumab Pegol; Etanercept; Female; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Infliximab; Methotrexate; Neoplasms; Odds Ratio; Polyethylene Glycols; Randomized Controlled Trials as Topic; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha | 2014 |
Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors.
Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Attention; Benzhydryl Compounds; Brain Neoplasms; Central Nervous System Stimulants; Child; Child, Preschool; Cognitive Dysfunction; Comorbidity; Cranial Irradiation; Donepezil; Early Intervention, Educational; Education, Special; Head and Neck Neoplasms; Human Growth Hormone; Humans; Indans; Infant; Injections, Spinal; Memory, Short-Term; Methotrexate; Methylphenidate; Modafinil; Neoplasms; Neurosurgical Procedures; Nootropic Agents; Patient Education as Topic; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Quality of Life; Radiotherapy Dosage; Risk Factors; Severity of Illness Index; Sex Factors; Survivors; Thinking; Wakefulness-Promoting Agents; Young Adult | 2014 |
Mechanisms and implications of dual-acting methotrexate in folate-targeted nanotherapeutic delivery.
Topics: Animals; Antimetabolites, Antineoplastic; Dendrimers; Drug Carriers; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Methotrexate; Models, Molecular; Nanoparticles; Neoplasms | 2015 |
Chemotherapy- and irradiation-induced bone loss in adults with solid tumors.
Topics: Adult; Antineoplastic Agents; Bone Resorption; Denosumab; Diphosphonates; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Imatinib Mesylate; Methotrexate; Neoplasms; Radioisotopes; Radiotherapy; Taxoids | 2015 |
Methotrexate.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Home Health Nursing; Humans; Long-Term Care; Methotrexate; Neoplasms; Patient Education as Topic; Rheumatic Diseases; Risk Assessment | 2015 |
Predicting Anthracycline Benefit: TOP2A and CEP17-Not Only but Also.
Topics: Anthracyclines; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Centromere; Chromosomes, Human, Pair 17; Clinical Trials, Phase III as Topic; Cyclophosphamide; Disease-Free Survival; DNA Topoisomerases, Type II; DNA-Binding Proteins; Fluorescent Dyes; Fluorouracil; Genetic Markers; Humans; In Situ Hybridization, Fluorescence; Methotrexate; Neoplasm Recurrence, Local; Neoplasms; Poly-ADP-Ribose Binding Proteins; Prognosis; Proportional Hazards Models; Treatment Outcome | 2015 |
Cucurbitacins: A Systematic Review of the Phytochemistry and Anticancer Activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Cucurbitacins; Docetaxel; Drug Therapy, Combination; Humans; Methotrexate; Molecular Conformation; Neoplasm Invasiveness; Neoplasms; Phytotherapy; Signal Transduction; Structure-Activity Relationship; Taxoids | 2015 |
Methotrexate in Moderate to Severe Psoriasis: Review of the Literature and Expert Recommendations.
Topics: Contraindications; Hepatitis B, Chronic; HIV Infections; Humans; Methotrexate; Neoplasms; Practice Guidelines as Topic; Psoriasis; Risk Factors | 2016 |
The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice.
Topics: Animals; Antineoplastic Agents; Camptothecin; Doxorubicin; Drug Interactions; Gene Expression; Hepatocytes; Humans; Inactivation, Metabolic; Irinotecan; Liver; Liver-Specific Organic Anion Transporter 1; Methotrexate; Mice; Mice, Transgenic; Neoplasms; Niacinamide; Organic Cation Transport Proteins; Phenylurea Compounds; Platinum Compounds; Sorafenib; Taxoids | 2016 |
Combination of metformin with chemotherapeutic drugs via different molecular mechanisms.
Topics: Androgen Antagonists; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Deoxycytidine; Estrogen Receptor Modulators; Fluorouracil; Gemcitabine; Humans; Metformin; Methotrexate; Neoplasms; Paclitaxel; Tubulin Modulators | 2017 |
Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bayes Theorem; Biological Products; Disease Progression; Humans; Methotrexate; Neoplasms; Network Meta-Analysis; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Treatment Failure | 2017 |
Pharmacogenetics of the neurodevelopmental impact of anticancer chemotherapy.
Topics: Antineoplastic Agents; Child; Combined Modality Therapy; Cranial Irradiation; Developmental Disabilities; Glucocorticoids; Humans; Methotrexate; Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Risk Factors | 2008 |
Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Humans; Infections; Long-Term Care; Methotrexate; Neoplasms; Pneumonia; Risk Factors | 2009 |
C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Quinazolines; Thiophenes; Treatment Outcome | 2009 |
Role of the MTHFR polymorphisms in cancer risk modification and treatment.
Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Polymorphism, Single Nucleotide; Risk Factors | 2009 |
Comorbidities in patients with psoriasis.
Topics: Arthritis, Psoriatic; Cardiovascular Diseases; Dermatologic Agents; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Methotrexate; Neoplasms; Obesity; Psoriasis | 2009 |
Dendrimer-based nanoparticles for cancer therapy.
Topics: Animals; Antineoplastic Agents; Capillary Permeability; Carrier Proteins; Contrast Media; Dendrimers; DNA; Drug Carriers; Drug Delivery Systems; Drug Design; Fluorescein-5-isothiocyanate; Folate Receptors, GPI-Anchored; Humans; KB Cells; Methotrexate; Mice; Mice, Nude; Models, Molecular; Nanoparticles; Neoplasms; Receptors, Cell Surface; Tissue Distribution; Xenograft Model Antitumor Assays | 2009 |
Non-infectious granulomatous diseases of the skin and their associated systemic diseases: an evidence-based update to important clinical questions.
Topics: Antirheumatic Agents; Crohn Disease; Dermatitis; Diabetes Mellitus; Granuloma; Humans; Methotrexate; Necrobiosis Lipoidica; Neoplasms; Neutrophils; Paraproteinemias; Rheumatoid Nodule; Sarcoidosis; Xanthomatosis | 2010 |
Golimumab and malignancies: true or false association?
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Neoplasms | 2011 |
[Therapy for childhood uveitis: biologics: too often--too late?].
Topics: Adalimumab; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Blindness; Certolizumab Pegol; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Immunoglobulin Fab Fragments; Immunosuppressive Agents; Infliximab; Lymphoma; Methotrexate; Neoplasms; Polyethylene Glycols; Randomized Controlled Trials as Topic; Risk Factors; Tumor Necrosis Factor-alpha; Uveitis | 2011 |
Tumor necrosis factor therapy and the risk of serious infection and malignancy in patients with early rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Communicable Diseases; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Randomized Controlled Trials as Topic; Risk; Treatment Outcome; Tumor Necrosis Factor-alpha | 2011 |
Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses.
Topics: Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Intercellular Adhesion Molecule-1; Isoxazoles; Leflunomide; Liver; Lung Diseases; Lymphocyte Function-Associated Antigen-1; Methotrexate; Neoplasms; Pharmacogenetics; Rituximab; Tumor Necrosis Factor-alpha | 2011 |
Central neurotoxicity in cancer chemotherapy: pharmacogenetic insights.
Topics: Antineoplastic Agents; Apolipoproteins E; Blood-Brain Barrier; Central Nervous System Diseases; Humans; Metabolic Networks and Pathways; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Pharmacogenetics; Polymorphism, Genetic | 2011 |
Pharmacogenomics of serious adverse drug reactions in pediatric oncology.
Topics: Anthracyclines; Antineoplastic Agents; Child; Cisplatin; Humans; Methotrexate; Neoplasms; Peripheral Nervous System Diseases; Pharmacogenetics; Vincristine; Warfarin | 2011 |
Methotrexate toxicity in growing long bones of young rats: a model for studying cancer chemotherapy-induced bone growth defects in children.
Topics: Animals; Antineoplastic Agents; Bone Development; Bone Diseases; Child; Disease Models, Animal; Humans; Methotrexate; Neoplasms; Rats | 2011 |
Pharmacokinetic drug-drug interactions with methotrexate in oncology.
Topics: Animals; Drug Interactions; Humans; Medical Oncology; Methotrexate; Neoplasms; Organic Anion Transporters | 2011 |
Chemotherapy in newborns and preterm babies.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child Development; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Infant; Infant, Newborn; Infant, Premature; Medical Oncology; Methotrexate; Neonatology; Neoplasms | 2012 |
The antifolates.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Molecular Targeted Therapy; Neoplasms | 2012 |
Biomodulatory approaches to photodynamic therapy for solid tumors.
Topics: Aminolevulinic Acid; Humans; Methotrexate; Neoplasms; Oxygen; Photochemotherapy; Photosensitizing Agents; Porphyrins; Vitamin D | 2012 |
Forward chemical genetics in yeast for discovery of chemical probes targeting metabolism.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Screening Assays, Antitumor; Glycolysis; Humans; Leucovorin; Methotrexate; Molecular Targeted Therapy; Mutagenesis; Neoplasms; Phenotype; Saccharomyces cerevisiae | 2012 |
A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis.
Topics: Animals; Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Delivery Systems; Humans; Methotrexate; Neoplasms | 2013 |
The application of electroporation to transfect hematopoietic cells and to deliver drugs and vaccines transcutaneously for cancer treatment.
Topics: Administration, Cutaneous; Aminolevulinic Acid; Animals; Antigens, CD34; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bone Marrow Cells; Cancer Vaccines; Dendritic Cells; Dose-Response Relationship, Drug; Drug Delivery Systems; Electroporation; Hematopoietic Stem Cells; Humans; Killer Cells, Natural; Lipids; Methotrexate; Microscopy, Fluorescence; Neoplasms; Peptides; Photosensitizing Agents; Transfection | 2002 |
[Cerebral ischemic events and anti-cancer therapy].
Topics: Adolescent; Adult; Antineoplastic Agents; Asparaginase; Brain Ischemia; Cerebral Hemorrhage; Child; Child, Preschool; Cisplatin; Disease Susceptibility; Female; Fluorouracil; Growth Inhibitors; Humans; Male; Methotrexate; Middle Aged; Neoplasms | 2003 |
THE MECHANISM OF ACTION OF THE FOLATE ANTAGONISTS IN MAN.
Topics: Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Methotrexate; Neoplasms; Oxidoreductases; Pharmacology | 1963 |
[MEDICAL THERAPY OF MALIGNANT NEOPLASMS].
Topics: Antimetabolites; Antineoplastic Agents; Antiviral Agents; Blood Transfusion; Busulfan; Chlorambucil; Cyclophosphamide; Dactinomycin; Diet; Diet Therapy; Estrogens; Female; Iodine Isotopes; Mechlorethamine; Methotrexate; Neoplasms; Phosphorus Isotopes; Prednisone; Pregnancy; Pregnancy Complications; Progesterone; Testosterone; Triethylenemelamine; Vinblastine; Vitamins | 1964 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
NEWER ANTICANCER AGENTS.
Topics: Alkylating Agents; Antineoplastic Agents; Arsenicals; Cyclophosphamide; Dactinomycin; Fluorouracil; Humans; Mechlorethamine; Melphalan; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Pharmacology; Steroids; Triethylenemelamine; Vinblastine; Vincristine | 1964 |
[CHEMOTHERAPY OF UTERINE CERVIX CARCINOMA].
Topics: Antineoplastic Agents; Azaguanine; Aziridines; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Female; Fluorouracil; Humans; Infusions, Parenteral; Melphalan; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Triaziquone; Uracil Mustard; Uterine Cervical Neoplasms; Vinblastine | 1964 |
THERAPY OF THE MALIGNANT CARCINOID SYNDROME.
Topics: Anti-Allergic Agents; Antihypertensive Agents; Cyclophosphamide; Fluorouracil; Histamine H1 Antagonists; Humans; Malignant Carcinoid Syndrome; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Selective Serotonin Reuptake Inhibitors; Serotonin; Steroids; Surgical Procedures, Operative | 1965 |
Considerations with the use of biological therapy in the treatment of rheumatoid arthritis.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Clinical Trials as Topic; Combined Modality Therapy; Cytokines; Demyelinating Diseases; Disease Progression; Drug Therapy, Combination; Erythema; Heart Failure; Humans; Immunocompromised Host; Immunologic Factors; Interleukin-1; Methotrexate; Neoplasms; Opportunistic Infections; Tuberculosis; Tumor Necrosis Factor-alpha | 2004 |
Homocysteine: exploring its potential as a pharmacodynamic biomarker of antifolate chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Neoplasms | 2004 |
Uridine diphosphoglucuronosyl transferase and methylenetetrahydrofolate reductase polymorphisms as genomic predictors of toxicity and response to irinotecan-, antifolate- and fluoropyrimidine-based chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Sensitivity and Specificity; Toxicogenetics | 2004 |
Pharmacogenetics of folate-related drug targets in cancer treatment.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Models, Biological; Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Thymidylate Synthase | 2005 |
Potential mechanisms for chemotherapy-induced impairments in cognitive function.
Topics: Anemia; Animals; Antineoplastic Agents; Attention; Blood-Brain Barrier; Cognition Disorders; Cyclophosphamide; Doxorubicin; Encephalitis; Fluorouracil; Humans; Inflammation; Language; Learning; Memory; Menopause; Methotrexate; Neoplasms; Oncology Nursing; Paclitaxel; Psychomotor Performance; Spatial Behavior | 2005 |
[SNPs associated with adverse effects].
Topics: Antineoplastic Agents; Camptothecin; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide | 2005 |
From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Resistance, Neoplasm; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Neoplasms; Pemetrexed; Randomized Controlled Trials as Topic | 2006 |
Understanding and managing methotrexate nephrotoxicity.
Topics: Antimetabolites, Antineoplastic; gamma-Glutamyl Hydrolase; Humans; Leucovorin; Methotrexate; Neoplasms; Renal Insufficiency | 2006 |
ABCC10, ABCC11, and ABCC12.
Topics: Animals; ATP-Binding Cassette Transporters; Cerumen; Dehydroepiandrosterone Sulfate; Drug Resistance, Multiple; Gene Expression Regulation; Humans; Methotrexate; Multidrug Resistance-Associated Proteins; Neoplasms; Nucleotides, Cyclic; Substrate Specificity | 2007 |
[Link between rheumatoid arthritis and cancer].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Comorbidity; Cross-Sectional Studies; Epstein-Barr Virus Infections; Female; Hodgkin Disease; Humans; Incidence; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasms; Risk Factors; Tumor Necrosis Factor-alpha | 2006 |
[CARIMS (Cancer Risk In Multiple Sclerosis) project: impact of long-term treatment].
Topics: Cyclophosphamide; Humans; Immunologic Factors; Immunosuppressive Agents; Incidence; Methotrexate; Multiple Sclerosis; Neoplasms; Risk Factors; Time Factors | 2007 |
[Guideline 'Leptomeningeal metastases of solid tumours'].
Topics: Antimetabolites, Antineoplastic; Combined Modality Therapy; Cranial Irradiation; Diagnosis, Differential; Humans; Karnofsky Performance Status; Meningeal Neoplasms; Meninges; Methotrexate; Neoplasm Metastasis; Neoplasms; Neurologic Examination; Practice Guidelines as Topic; Prognosis | 2007 |
[Induction of malignant neoplasm].
Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Etanercept; Humans; Immunoglobulin G; Infliximab; Lymphoma; Methotrexate; Neoplasms; Receptors, Tumor Necrosis Factor; Risk; Tumor Necrosis Factor-alpha | 2007 |
Thymidine as an anticancer agent, alone or in combination. A biochemical appraisal.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cytarabine; Decitabine; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Neoplasms; Thymidine | 1982 |
[Recent developments in chemotherapy of malignant diseases].
Topics: Anthraquinones; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Female; Genetic Techniques; Hodgkin Disease; Hormones; Humans; Immunotherapy; Interferons; Male; Mechlorethamine; Methotrexate; Mitoxantrone; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Nitrosourea Compounds; Osteosarcoma; Prednisone; Procarbazine; Prognosis; Receptors, Cell Surface; Tretinoin; Vincristine | 1982 |
The Franz Buschke lecture: late effects of chemotherapy and radiation therapy: a new hypothesis.
Topics: Antineoplastic Agents; Bleomycin; Bone Marrow Diseases; Brain Diseases; Cardiomyopathies; Carmustine; Cisplatin; Doxorubicin; Gastrointestinal Diseases; Humans; Kidney Diseases; Liver Diseases; Lung Diseases; Methotrexate; Neoplasms; Radiotherapy | 1984 |
The pharmacology and clinical use of methotrexate.
Topics: Administration, Oral; Animals; Biological Transport; Central Nervous System; Drug Resistance; Folic Acid; Folic Acid Antagonists; Gene Amplification; Head and Neck Neoplasms; Humans; Kinetics; Leucovorin; Leukemia, Lymphoid; Lung Neoplasms; Methotrexate; Neoplasms; Osteoma, Osteoid; Thymidylate Synthase; Tissue Distribution | 1983 |
Gene amplification and altered enzymes as mechanisms for the development of drug resistance.
Topics: Animals; Drug Resistance; Gene Amplification; Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 1983 |
The forty-year-old mutation theory of Luria and Delbrück and its pertinence to cancer chemotherapy.
Topics: Animals; Cell Division; Cell Line; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Humans; Leukemia; Mathematics; Methotrexate; Models, Genetic; Mutation; Neoplasms; Time Factors | 1983 |
[Molecular mechanisms of cellular resistance to antifolates].
Topics: Animals; Biological Availability; Biological Transport; Carcinoma 256, Walker; Cricetinae; Cricetulus; Drug Resistance; Enzyme Activation; Enzyme Induction; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms; RNA, Messenger; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase | 1983 |
[The theory and practice of chemotherapy by arterial infusion--the importance of pharmacokinetic research].
Topics: Animals; Antineoplastic Agents; Capillary Permeability; Colonic Neoplasms; Doxorubicin; Humans; Infusions, Intra-Arterial; Kinetics; Methotrexate; Neoplasms; Stomach Neoplasms | 1984 |
Biological effects of folic acid antagonists with antineoplastic activity.
Topics: Animals; Bone Marrow; Cell Cycle; Flow Cytometry; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Neoplasms; Structure-Activity Relationship; Thymidylate Synthase; Tritium | 1984 |
Spinal cord disorders in patients with cancer.
Topics: Anemia, Pernicious; Central Nervous System Diseases; Encephalomyelitis; Humans; Infections; Methotrexate; Motor Neurons; Neoplasm Metastasis; Neoplasms; Nerve Degeneration; Neuromuscular Diseases; Paraneoplastic Syndromes; Radiation Injuries; Spinal Cord; Spinal Cord Diseases; Spinal Cord Injuries | 1984 |
Selective uptake and retention of anticancer agents by sensitive cells.
Topics: Animals; Antineoplastic Agents; Cytarabine; Doxorubicin; Floxuridine; Fluorouracil; Humans; Melphalan; Methotrexate; Neoplasms | 1980 |
Experience gained in immunotherapy from the immunopharmacology of BCG leading to a second generation of systemic immunity adjuvants.
Topics: Adjuvants, Immunologic; Animals; Aziridines; BCG Vaccine; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Immunologic; Humans; Immunotherapy; Leucine; Leukemia L1210; Leukemia, Lymphoid; Levamisole; Lymphoma, Non-Hodgkin; Melanoma; Methotrexate; Mice; Neoplasms; Propionibacterium acnes; T-Lymphocytes, Regulatory; Thymosin | 1980 |
Antineoplastic agents: high-dose methotrexate and citrovorum factor rescue.
Topics: Dose-Response Relationship, Drug; Humans; Kinetics; Leucovorin; Methotrexate; Neoplasms | 1980 |
Is there a role for thymidine in cancer chemotherapy?
Topics: Cytarabine; Drug Therapy, Combination; Fluorouracil; Humans; Kinetics; Leukemia; Methotrexate; Neoplasms; Thymidine | 1982 |
The effect of chemotherapeutic agents on wound healing.
Topics: Adrenal Cortex Hormones; Anemia; Animals; Antineoplastic Agents; Azathioprine; Collagen; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; Humans; Leukopenia; Mechlorethamine; Mercaptopurine; Methotrexate; Neoplasms; Tensile Strength; Thiotepa; Time Factors; Wound Healing | 1981 |
[Metabolic modulation as a method in tumor chemotherapy].
Topics: Antineoplastic Agents; Cytarabine; Fluorouracil; Humans; Methotrexate; Neoplasms; Tegafur; Thymidine; Uracil | 1982 |
An overview of thymidine.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Methylthioinosine; Mice; Neoplasms; Thymidine | 1980 |
A critical review of the use of vincristine (VCR) as a tumour cell synchronizing agent in cancer therapy.
Topics: Animals; Cell Cycle; Cyclophosphamide; Cytological Techniques; Drug Therapy, Combination; Humans; Interphase; Kinetics; Metaphase; Methotrexate; Mice; Neoplasms; Vincristine | 1980 |
Problems in the chemotherapy of cancer in the neonate.
Topics: Age Factors; Antineoplastic Agents, Phytogenic; Blood Proteins; Glomerular Filtration Rate; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Kidney Tubules; Methotrexate; Neoplasms; Phenobarbital | 1981 |
Interaction of drugs and radiation - promise or pitfall?
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Humans; Male; Methotrexate; Neoplasms; Prognosis; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1982 |
Report on various clinical studies on high dose methotrexate in Europe (non EORTC).
Topics: Clinical Trials as Topic; Europe; Female; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma | 1981 |
Application of network thermodynamics to the computer modeling of the pharmacology of anticancer agents: a network model for methotrexate action as a comprehensive example.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Membrane; Computers; Humans; Kinetics; Leukemia L1210; Methotrexate; Models, Theoretical; Neoplasms; Thermodynamics | 1981 |
Dihydrofolate reductase inhibitors as potential drugs.
Topics: Aminopterin; Animals; Antimalarials; Bacterial Infections; Biological Transport; Drug Interactions; Folic Acid; Folic Acid Antagonists; Helminthiasis; Humans; Immunosuppressive Agents; Leukemia, Experimental; Liver; Methotrexate; Mice; Mycoses; Neoplasms; Protozoan Infections; Psoriasis; Quinazolines; Rats; Receptors, Drug; Trypanosoma cruzi | 1981 |
Molecular biology of double-minute chromosomes.
Topics: Animals; Cell Cycle; CHO Cells; Chromatin; Chromosome Aberrations; Chromosomes; Cricetinae; DNA Damage; DNA, Circular; DNA, Neoplasm; Drug Resistance; Extrachromosomal Inheritance; Gene Amplification; Humans; Methotrexate; Models, Genetic; Neoplasms; Staining and Labeling; Tetrahydrofolate Dehydrogenase | 1993 |
The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data.
Topics: Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms; Phosphonoacetic Acid; Trimetrexate | 1994 |
The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.
Topics: Antimetabolites, Antineoplastic; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms | 1994 |
Clinical pharmacokinetics of anti-metabolites.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Cytarabine; Fluorouracil; Humans; Mercaptopurine; Methotrexate; Neoplasms | 1993 |
Concepts in use of high-dose methotrexate therapy.
Topics: Adult; Aging; Animals; Antimetabolites, Antineoplastic; Bone Marrow Diseases; Child; Drug Monitoring; Humans; Methotrexate; Middle Aged; Neoplasms | 1996 |
Methotrexate: an effective agent for treating cancer and building careers. The polyglutamate era.
Topics: Animals; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Leucovorin; Methotrexate; Mice; Neoplasms; Polyglutamic Acid | 1996 |
Molecular mechanisms of resistance to antifolates, a review.
Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Folic Acid Antagonists; Gene Amplification; Genes, Tumor Suppressor; Genetic Therapy; Humans; Methotrexate; Mutation; Neoplasms; Protein Biosynthesis; Proto-Oncogene Proteins c-bcl-2; Tetrahydrofolate Dehydrogenase | 1995 |
Folate, antifolates, and folate analogs in pediatric oncology.
Topics: Antimetabolites, Antineoplastic; Child; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms | 1996 |
[Methotrexate-leucovorin rescue therapy: pharmacological characteristics and clinical effective use].
Topics: Antidotes; Antimetabolites, Antineoplastic; Bone Neoplasms; Drug Synergism; Humans; Leucovorin; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasms; Osteosarcoma | 1996 |
Study of eight cases of cancer in 426 rheumatoid arthritis patients treated with methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; France; Humans; Incidence; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasms; Retrospective Studies | 1997 |
[Acquisition of resistance to anticancer agents by overproduction of target enzymes].
Topics: Animals; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Enzymes; Fluorouracil; Gene Amplification; Genetic Code; Humans; Methotrexate; Neoplasms | 1997 |
Does methotrexate increase the risk of infection or malignancy?
Topics: AIDS-Related Opportunistic Infections; Antirheumatic Agents; Bacterial Infections; Humans; Immunocompromised Host; Methotrexate; Neoplasms; Virus Diseases | 1997 |
Tumor resistance to antimetabolites.
Topics: Antimetabolites, Antineoplastic; Cell Cycle Proteins; Deoxycytidine; DNA Damage; DNA, Neoplasm; Drug Resistance, Neoplasm; Fluorouracil; Gemcitabine; Gene Amplification; Humans; Methotrexate; Mutation; Neoplasms; Quinazolines; Thiophenes | 1998 |
Methotrexate and emerging therapies.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Therapy; Humans; Methotrexate; Neoplasms; Opportunistic Infections | 1998 |
Therapeutic strategies targeting proteins that regulate folate and reduced folate transport.
Topics: Antimetabolites, Antineoplastic; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Receptors, Cell Surface; Trimetrexate | 1999 |
Therapeutic drug monitoring of antimetabolic cytotoxic drugs.
Topics: Antimetabolites, Antineoplastic; Cytarabine; Drug Monitoring; Fluorouracil; Humans; Mercaptopurine; Methotrexate; Neoplasms | 1999 |
[Methotrexate].
Topics: Antimetabolites, Antineoplastic; Contraindications; Drug Interactions; Enzyme Inhibitors; Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 2000 |
Nonmyeloablative hematopoietic cell transplantation. Replacing high-dose cytotoxic therapy by the graft-versus-tumor effect.
Topics: Adult; Animals; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclosporine; Disease Progression; Dogs; Forecasting; Graft Enhancement, Immunologic; Graft Survival; Graft vs Host Disease; Graft vs Tumor Effect; Hematopoietic Stem Cell Transplantation; Histocompatibility; Humans; Immunosuppressive Agents; Lymphocyte Transfusion; Methotrexate; Middle Aged; Mycophenolic Acid; Neoplasms; Prednisone; Radiation Chimera; T-Lymphocytes, Cytotoxic; Tissue Donors; Transplantation Conditioning; Transplantation, Homologous; Treatment Outcome; Vidarabine; Whole-Body Irradiation | 2001 |
Malignancy and renal disease.
Topics: Acute Kidney Injury; Antineoplastic Agents; Bone Marrow Transplantation; Cisplatin; Cyclosporine; Hepatorenal Syndrome; Humans; Kidney Diseases; Methotrexate; Multiple Myeloma; Neoplasms; Renal Replacement Therapy | 2001 |
Therapeutic drug monitoring of cytotoxic drugs.
Topics: Antimetabolites, Antineoplastic; Drug Interactions; Drug Monitoring; Fluorouracil; Humans; Mercaptopurine; Methotrexate; Neoplasms | 2001 |
Chemotherapy-induced neurotoxicity: assessment and interventions for patients at risk.
Topics: Antineoplastic Agents; Cisplatin; Cytarabine; Humans; Ifosfamide; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Nursing Assessment; Oncology Nursing; Paclitaxel; Vinca Alkaloids | 2002 |
[Adult Still's disease: study of a series of 11 cases].
Topics: Adult; Anemia; Diagnosis, Differential; Exanthema; Female; Ferritins; Fever; Humans; Incidence; Infections; Liver Function Tests; Male; Methotrexate; Neoplasms; Pain; Prednisone; Prevalence; Retrospective Studies; Still's Disease, Adult-Onset | 2002 |
Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Cycle Proteins; Dihydrouracil Dehydrogenase (NADP); DNA-Binding Proteins; Drug Resistance, Neoplasm; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Nucleoside-Phosphate Kinase; Oxidoreductases; Tetrahydrofolate Dehydrogenase; Thymidine Phosphorylase; Thymidylate Synthase; Transcription Factors | 2002 |
Current concepts of chemotherapy combined with other modalities for head and neck cancer.
Topics: Bleomycin; Carcinoma, Squamous Cell; Cyclophosphamide; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Hydroxyurea; Immunotherapy; Laryngeal Neoplasms; Leucovorin; Methotrexate; Neoplasm Metastasis; Neoplasms; Radiotherapy; Vinblastine | 1975 |
Advances in cancer chemotherapy.
Topics: Bleomycin; Burkitt Lymphoma; Carcinoma, Basal Cell; Choriocarcinoma; Cyclophosphamide; Cytarabine; Dacarbazine; Doxorubicin; Female; Humans; Lomustine; Lung Neoplasms; Methotrexate; Mitosis; Neoplasms; Pregnancy; Skin Neoplasms; Vincristine | 1975 |
Immunosuppressive and cytotoxic chemotherapy: long-term complications.
Topics: Alkylating Agents; Antineoplastic Agents; Azathioprine; Bleomycin; Busulfan; Carcinogens; Chemical and Drug Induced Liver Injury; Daunorubicin; Doxorubicin; Female; Fetus; Folic Acid Antagonists; Follow-Up Studies; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Infertility, Female; Infertility, Male; Liver; Lung Diseases; Male; Mercaptopurine; Methotrexate; Myocarditis; Neoplasms; Ovary; Pregnancy; Procarbazine; Streptozocin; Testis; Urologic Diseases | 1975 |
Serious toxicities associated with chemotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Asparaginase; Bleomycin; Cisplatin; Cyclophosphamide; Daunorubicin; Doxorubicin; Emergencies; Estradiol Congeners; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Nitrosourea Compounds; Plicamycin; Testosterone Congeners; Vinca Alkaloids | 1978 |
Pulmonary toxicity of antineoplastic drugs.
Topics: Antineoplastic Agents; Bleomycin; Busulfan; Cyclophosphamide; Humans; Lung Diseases; Methotrexate; Neoplasms; Nitrosourea Compounds | 1978 |
The clinical pharmacology of antineoplastic agents (first of two parts).
Topics: Animals; Antineoplastic Agents; Asparaginase; Binding Sites; Biological Transport; Chemical and Drug Induced Liver Injury; Depression, Chemical; DNA, Neoplasm; Drug Interactions; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Kidney Diseases; Liver; Lung Diseases; Methotrexate; Mice; Neoplasms; Tetrahydrofolate Dehydrogenase | 1975 |
The success and failure of multimodal therapy for cancer in children.
Topics: Adolescent; Age Factors; Child; Dactinomycin; Humans; Lymph Node Excision; Male; Methotrexate; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Osteosarcoma; Prognosis; Retinoblastoma; Rhabdomyosarcoma; Sarcoma; Testicular Neoplasms; Vincristine; Wilms Tumor | 1975 |
Chemotherapy of solid tumors. Recent advances.
Topics: Adult; Alkylating Agents; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Child; Cyclophosphamide; Doxorubicin; Drug Combinations; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunotherapy; Leucovorin; Male; Melphalan; Methotrexate; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Prednisone; Rhabdomyosarcoma; Testicular Neoplasms; Thiotepa; Vinblastine; Vincristine | 1976 |
The effects of cancer therapy on the nervous system.
Topics: Acute Disease; Antineoplastic Agents; Brain Diseases; Central Nervous System Diseases; Child; Child, Preschool; Chronic Disease; Humans; Methotrexate; Neoplasms; Peripheral Nervous System Diseases; Radiotherapy; Spinal Cord Diseases; Time Factors; Vincristine | 1978 |
Immunologic aspects of cancer chemotherapy.
Topics: Animals; BCG Vaccine; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Immunotherapy; Levamisole; Mercaptopurine; Methotrexate; Mice; Neoplasms; Propionibacterium acnes; Vinca Alkaloids | 1977 |
The action of antitumor agents: a double-edged sword?
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Burkitt Lymphoma; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Immunosuppressive Agents; Kidney Neoplasms; Leukemia, Myeloid, Acute; Lymphoma; Mechlorethamine; Melphalan; Mercaptopurine; Methotrexate; Mice; Multiple Myeloma; Neoplasms; Prednisone; Pregnancy; Procarbazine; Time Factors; Vincristine | 1977 |
Pharmacokinetics: selectivity of action related to physicochemical properties and kinetic patterns of anticancer drugs.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Brain Neoplasms; Chlorobenzenes; Chromatography; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Kinetics; Lipids; Methotrexate; Neoplasms; Neoplasms, Experimental; Pyrimidines; Radioimmunoassay; Solubility | 1977 |
Multiple basis of combination chemotherapy.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Antagonism; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Humans; Leucovorin; Mercaptopurine; Methotrexate; Neoplasms; Neoplasms, Experimental; Uridine | 1977 |
Methotrexate: clinical pharmacology, current status and therapeutic guidelines.
Topics: Antineoplastic Agents; Drug Interactions; Drug Therapy, Combination; Folic Acid Antagonists; Half-Life; Humans; Leucovorin; Leukoencephalopathy, Progressive Multifocal; Liver; Methotrexate; Neoplasms | 1977 |
High-dose methotrexate with folinic acid rescue.
Topics: Absorption; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Monitoring, Physiologic; Neoplasms; Time Factors | 1977 |
The clinical pharmacology of methotrexate: new applications of an old drug.
Topics: Absorption; Bone Marrow; Cell Cycle; Drug Interactions; Drug Resistance; Folic Acid Antagonists; History, 20th Century; Humans; Injections, Intravenous; Injections, Spinal; Leucovorin; Methotrexate; Neoplasms; Nervous System; Research Design; Tissue Distribution; United States | 1978 |
Individual cell biology: basis and prospects for a rational cancer chemotherapy.
Topics: Adenocarcinoma; Brain Neoplasms; Breast Neoplasms; Cell Cycle; Chromosome Aberrations; Cyclophosphamide; Dactinomycin; DNA, Neoplasm; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Fructose-Bisphosphate Aldolase; Humans; Isoenzymes; Kinetics; Male; Methotrexate; Neoplasm Staging; Neoplasms; Prognosis | 1977 |
Studies with high-dose methotrexate--historical background.
Topics: Aminopterin; Animals; Folic Acid; History, 20th Century; Humans; Leucovorin; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Time Factors | 1978 |
Biochemical mechanisms of resistance to antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; DNA, Neoplasm; Drug Resistance; Folic Acid Antagonists; Humans; In Vitro Techniques; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 1978 |
Chemotherapy of non-Hodgkin lymphoma: the diffuse types.
Topics: Antineoplastic Agents; Central Nervous System Diseases; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Humans; Leucovorin; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; Vincristine | 1978 |
Third Myron Karon Memorial Lecture. Resistance of human tumors to cancer chemotherapeutic agents: an important research problem.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Drug Resistance; Humans; Methotrexate; Neoplasms; Neoplasms, Experimental; Research; RNA, Messenger; Tetrahydrofolate Dehydrogenase | 1978 |
Towards selectivity in cancer chemotherapy: a biochemical overview.
Topics: Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Drug Administration Schedule; Folic Acid Antagonists; Humans; Methotrexate; Neoplasm Proteins; Neoplasms; Platinum; Protein Biosynthesis; Transcription, Genetic; Triazenes; Triazines | 1978 |
High-dose methotrexate therapy--an area of uncertainty.
Topics: Humans; Kinetics; Leucovorin; Methotrexate; Neoplasms; Protein Binding | 1979 |
Late side effects of treatment: skeletal, genetic, central nervous system, and oncogenic.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antineoplastic Agents; Busulfan; Carcinogens; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Female; Heart Diseases; Humans; Lung Diseases; Male; Menstruation Disturbances; Mercaptopurine; Methotrexate; Neoplasms; Neoplasms, Radiation-Induced; Pregnancy; Radiotherapy; Urinary Bladder Diseases | 1976 |
Selective suppression of humoral immunity by antineoplastic drugs.
Topics: Animals; Antineoplastic Agents; Binding Sites; Chickens; Cyclophosphamide; Cytarabine; Fluorouracil; Guinea Pigs; Humans; Immunity; Immunity, Cellular; Immunosuppressive Agents; Leucovorin; Male; Mercaptopurine; Methotrexate; Mice; Neoplasms; Piperazines; Rats; Stimulation, Chemical | 1976 |
[Polymyositis].
Topics: Antineoplastic Agents; Child; Dermatomyositis; Enzymes; Humans; Immunosuppression Therapy; Methotrexate; Muscle Tonus; Muscular Atrophy; Myositis; Neoplasms; Pain; Paralysis; Prednisone | 1976 |
Recent developments in chemotherapy of malignancy.
Topics: Alkaloids; Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Cell Survival; Child; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Humans; Immunotherapy; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Neoplasms; Plants, Medicinal; Vincristine | 1975 |
Hypersensitivity reactions.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Aziridines; Benzoquinones; Bleomycin; Chlorambucil; Cisplatin; Cyclophosphamide; Cytarabine; Dacarbazine; Drug Hypersensitivity; Etoposide; Fluorouracil; Humans; Ifosfamide; Melphalan; Methotrexate; Mitomycins; Neoplasms; Paclitaxel; Pentostatin; Procarbazine; Teniposide | 1992 |
Antimetabolites.
Topics: Animals; Cytarabine; Drug Interactions; Drug Resistance; Fluorouracil; Humans; Methotrexate; Neoplasms | 1992 |
[Effect of antifolates and folates on the antineoplastic action of fluoropyrimidines].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Interactions; Fluorouracil; Humans; In Vitro Techniques; Leucovorin; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental | 1992 |
Disposition of antineoplastic agents in the very young child.
Topics: Age Factors; Antineoplastic Agents; Blood Proteins; Child; Child, Preschool; Doxorubicin; Etoposide; Humans; Infant; Infant, Newborn; Liver; Mercaptopurine; Methotrexate; Neoplasms; Nervous System; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide | 1992 |
[Clinical pharmacology of anticancer agents [Part 5] Antimetabolites (2)].
Topics: Antimetabolites, Antineoplastic; Folic Acid Antagonists; Guanine Nucleotides; Humans; Methotrexate; Neoplasms; Purines | 1992 |
Antimetabolites.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Cytarabine; Cytidine; Drug Interactions; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms | 1991 |
Nephrotoxicity from chemotherapy: prevention and management.
Topics: Antineoplastic Agents; Carboplatin; Cisplatin; Gallium; Humans; Ifosfamide; Kidney Diseases; Methotrexate; Mitomycin; Neoplasms; Nitrosourea Compounds; Plicamycin | 1991 |
Chemoprotectants for cancer chemotherapy.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Cisplatin; Cyclophosphamide; Fluorouracil; Humans; Ifosfamide; Leucovorin; Mesna; Methotrexate; Neoplasms; Razoxane; Sulfhydryl Compounds; Uridine | 1991 |
Acquired versus intrinsic resistance to methotrexate: diversity of the drug-resistant phenotype in mammalian cells.
Topics: Animals; Cricetinae; Drug Resistance; Folic Acid; Humans; Methotrexate; Mice; Neoplasms; Tetrahydrofolate Dehydrogenase | 1991 |
Genetic mechanisms of drug resistance. A review.
Topics: Alkylating Agents; Antineoplastic Agents; Drug Resistance; Humans; Membrane Proteins; Methotrexate; Mutation; Neoplasms | 1991 |
In vivo methotrexate kinetics and metabolism in human hematopoietic cells. Clinical significance of methotrexate concentrations in erythrocytes.
Topics: Erythrocytes; Humans; Leukemia; Metabolic Clearance Rate; Methotrexate; Neoplasms | 1990 |
Interaction between nonsteroidal anti-inflammatory drugs and high-dose methotrexate: a literature review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Interactions; Humans; Methotrexate; Neoplasms; Nursing Assessment; Self Medication | 1990 |
Pharmacokinetics and metabolism of methotrexate: an example for the use of clinical pharmacology in pediatric oncology.
Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Methotrexate; Neoplasms | 1990 |
Modulation of 5-fluorouracil efficacy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Evaluation; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms | 1990 |
Intracavitary chemotherapy.
Topics: Absorption; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Ascitic Fluid; Bacterial Infections; Bleomycin; Cisplatin; Cytarabine; Diffusion; Doxorubicin; Drug Synergism; Female; Fluorouracil; Humans; Immunotherapy; Melphalan; Methotrexate; Mitomycins; Neoplasms; Ovarian Neoplasms; Peritoneal Cavity; Permeability; Pleura; Pleural Effusion; Radiation-Sensitizing Agents; Sclerosis; Streptozocin | 1985 |
The cellular pharmacology of methotrexate.
Topics: Animals; Anions; Binding, Competitive; Biological Transport, Active; Carrier Proteins; Cell Line; Cell Membrane; Computers; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Folic Acid Antagonists; Humans; In Vitro Techniques; Leucovorin; Membrane Proteins; Methotrexate; Models, Biological; Neoplasms; Polyglutamic Acid; Structure-Activity Relationship; Tetrahydrofolates | 1985 |
[Current status of combination chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Humans; Methotrexate; Neoplasms; Vinblastine | 1986 |
Sequential chemotherapy with methotrexate and 5-fluorouracil: mechanism of synergistic effect.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Methotrexate; Neoplasms; Purines; RNA | 1986 |
Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Drug Administration Schedule; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Neoplasms; Nucleosides; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase | 1987 |
[Amethopterin metabolism in mammalian cells].
Topics: Animals; Antineoplastic Agents; Biotransformation; Catalysis; Chemical Phenomena; Chemistry; Humans; Hydrolysis; Liver; Methotrexate; Neoplasms; Neoplasms, Experimental; Polyglutamic Acid | 1988 |
Cancer chemotherapy in infants and children.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Bleomycin; Catheters, Indwelling; Child; Child, Preschool; Cisplatin; Cyclophosphamide; Cytarabine; Dacarbazine; Dactinomycin; Daunorubicin; Doxorubicin; Humans; Infant; Infant, Newborn; Infusions, Parenteral; Mercaptopurine; Methotrexate; Neoplasms; Nitrosourea Compounds; Thioguanine; Vinblastine; Vincristine | 1985 |
New vistas for leucovorin in cancer chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms | 1989 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemical and Drug Induced Liver Injury; Chlorambucil; Cyclophosphamide; Depression, Chemical; Dermatomyositis; Drug Evaluation; Female; Fertility; Gastrointestinal Diseases; Granulomatosis with Polyangiitis; Humans; Leukopenia; Lupus Erythematosus, Systemic; Male; Methotrexate; Myositis; Neoplasms; Polyarteritis Nodosa; Psoriasis; Pulmonary Fibrosis; Rheumatic Diseases | 1986 |
Chemotherapeutic potential of methotrexate peptides.
Topics: Animals; Antineoplastic Agents; Humans; Methotrexate; Mice; Neoplasms | 1988 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biological Assay; Biological Transport; Bone Marrow; Carrier Proteins; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Food Analysis; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kidney Failure, Chronic; Malabsorption Syndromes; Malaria; Methotrexate; Neoplasms; Nervous System Diseases; Nutritional Requirements; Parenteral Nutrition, Total; Pregnancy; Pyrimethamine; Receptors, Cell Surface; Terminology as Topic; Thalassemia; Transferases; Trimethoprim | 1986 |
Role of thymidine in biochemical modulation: a review.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cytarabine; Deoxycytidine Kinase; DNA Replication; DNA, Neoplasm; Drug Evaluation; Drug Synergism; Fluorouracil; Folic Acid Antagonists; Humans; Interphase; Kinetics; Leukemia; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nucleic Acid Synthesis Inhibitors; Nucleotides; Phosphonoacetic Acid; RNA, Neoplasm; Species Specificity; Thymidine | 1987 |
Antineoplastic drug monitoring.
Topics: Antineoplastic Agents; Drug Evaluation; Humans; Methotrexate; Monitoring, Physiologic; Neoplasms | 1987 |
Searching for magic bullets: early approaches to chemotherapy-antifolates, methotrexate--the Bruce F. Cain memorial award lecture.
Topics: Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Neoplasms | 1987 |
High-dose methotrexate: a critical reappraisal.
Topics: Humans; Leucovorin; Methotrexate; Neoplasms | 1987 |
New aspects of clinical drug resistance: the role of gene amplification and the reversal of resistance in drug refractory cancer.
Topics: Calcium Channel Blockers; Drug Resistance; Gene Amplification; Glutathione; Humans; Methotrexate; Neoplasms | 1986 |
Methotrexate resistance and gene amplification. Mechanisms and implications.
Topics: Animals; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosome Fragility; DNA Replication; Drug Resistance; Gene Amplification; Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 1986 |
Indications for and benefits of intensive therapies in treatment of childhood cancers.
Topics: Acute Disease; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Etoposide; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Melphalan; Methotrexate; Neoplasms; Osteosarcoma; Risk; Sarcoma, Ewing | 1986 |
Biological and biochemical properties of new anticancer folate antagonists.
Topics: Animals; Cell Line; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Structure-Activity Relationship | 1987 |
[Late effects of cancer chemotherapy].
Topics: Antineoplastic Agents; Bone and Bones; Chemical and Drug Induced Liver Injury; Cisplatin; Female; Fibrosis; Glomerular Filtration Rate; Humans; Kidney Diseases; Liver Cirrhosis; Male; Methotrexate; Neoplasm Metastasis; Neoplasms; Pituitary Gland; Pregnancy; Testis | 1987 |
Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer.
Topics: Animals; Biological Transport; Cell Division; Cell Transformation, Neoplastic; Extraembryonic Membranes; Female; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Neoplasms; Oncogenes; Pregnancy | 1985 |
Mechanisms of action and clinical applications of cytotoxic drugs in rheumatic disorders.
Topics: Arthritis, Reactive; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyositis; Granulomatosis with Polyangiitis; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Methotrexate; Neoplasms; Psoriasis; Vasculitis | 1985 |
[Drug interactions with anticancer agents].
Topics: Allopurinol; Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Interactions; Drug Therapy, Combination; Humans; Liver; Methotrexate; Neoplasms; Phenobarbital | 1985 |
Monoclonal antibody targeting of anti-cancer agents: Mühlbock memorial lecture.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Antigens, Neoplasm; Antineoplastic Agents; Binding Sites, Antibody; Carcinoembryonic Antigen; Colonic Neoplasms; Haptens; Humans; Iodine Radioisotopes; Methotrexate; Mice; Neoplasms; Ricin; Sarcoma, Experimental; Serum Albumin | 1985 |
Neurologic complications of systemic cancer.
Topics: Arachnoid; Bacterial Infections; Brain; Brain Neoplasms; Cerebrovascular Disorders; Cisplatin; Disseminated Intravascular Coagulation; Electroencephalography; Endocarditis; Fluorouracil; Humans; Lung Neoplasms; Melanoma; Meningeal Neoplasms; Methotrexate; Neoplasms; Nervous System Diseases; Paraneoplastic Syndromes; Pia Mater; Prognosis; Spinal Cord Compression; Spinal Cord Neoplasms; Tomography, X-Ray Computed; Vinca Alkaloids | 1985 |
Clinical pharmacology of very low dose methotrexate for use in rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Bile; Biological Availability; Brain; Breast Neoplasms; Cell Line; Half-Life; Humans; Intestinal Absorption; Kidney; Kinetics; Liver; Metabolic Clearance Rate; Methotrexate; Neoplasms; Psoriasis; Tritium | 1985 |
Toxicity of low dose methotrexate in rheumatoid arthritis.
Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infertility, Female; Infertility, Male; Kidney Diseases; Lung Diseases; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Random Allocation; Risk; Skin Diseases | 1985 |
Methotrexate resistant cells as targets for selective chemotherapy.
Topics: Animals; Cell Line; Drug Resistance; Folic Acid Antagonists; Gene Amplification; Humans; Methotrexate; Neoplasms; Neoplasms, Experimental; Tetrahydrofolate Dehydrogenase | 1985 |
[Cancerogenicity of cytostatics].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Azathioprine; Cell Transformation, Neoplastic; Dactinomycin; Humans; Immunosuppression Therapy; Methotrexate; Mitosis; Neoplasms; Rats; RNA, Messenger; RNA, Neoplasm | 1971 |
[Principles of the effect of cytostatics].
Topics: Antineoplastic Agents; Asparaginase; Cell Division; Chlorambucil; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Fluorouracil; Folic Acid Antagonists; Humans; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Triaziquone; Triethylenephosphoramide; Vincristine | 1974 |
Isozymes of aspartate aminotransferase in tissues and blood of man.
Topics: Acute Disease; Adult; Aging; Alpha-Globulins; Animals; Aspartate Aminotransferases; Aspartic Acid; Beta-Globulins; Cattle; Choriocarcinoma; Cytoplasm; Dogs; Electrophoresis; Erythrocytes; Female; gamma-Globulins; Gluconeogenesis; Humans; Hydrogen-Ion Concentration; Immune Sera; Immunochemistry; In Vitro Techniques; Isoenzymes; Ketoglutaric Acids; Kinetics; Liver; Methotrexate; Mitochondria; Myocardium; Neoplasms; Organ Specificity; Phenylhydrazines; Pregnancy; Rabbits; Rats; Reticulocytes; Starch | 1966 |
Solid tumor chemotherapy: What have we to offer.
Topics: Adult; Antineoplastic Agents; Child; Cyclophosphamide; Dactinomycin; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Palliative Care; Thiotepa; Time Factors; Vincristine | 1970 |
The use of cytotoxic drugs in the surgery of malignant disease.
Topics: Abdominal Neoplasms; Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Carcinoma, Basal Cell; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dysgerminoma; Female; Fluorouracil; Head; Head and Neck Neoplasms; Hodgkin Disease; Humans; Injections, Intra-Arterial; Leg; Melanoma; Melphalan; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Nitrogen Mustard Compounds; Pregnancy; Sarcoma; Sarcoma, Ewing; Skin Neoplasms; Vinblastine; Wilms Tumor | 1968 |
An assessment of massive-dose chemotherapy of malignant disease.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cyclophosphamide; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; Leukemia, Lymphoid; Lymphoma; Melphalan; Mercaptopurine; Methotrexate; Mice; Multiple Myeloma; Neoplasms; Nitrogen Mustard Compounds; Prednisone; Pregnancy; Time Factors; Trophoblastic Neoplasms; Vinblastine | 1971 |
Enhancement of radiation effects by chemotherapy.
Topics: Alkylating Agents; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Dactinomycin; DNA, Neoplasm; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Mouth Neoplasms; Neoplasms; Ovarian Neoplasms; Pharyngeal Neoplasms; Pyrimidines; Retinoblastoma; RNA, Neoplasm; Testicular Neoplasms; Urinary Bladder Neoplasms; Wilms Tumor | 1971 |
Antimetabolites and psoriasis.
Topics: Adrenal Cortex Hormones; Animals; Antimetabolites; Arsenic; Humans; Hydroxyurea; Methotrexate; Mice; Neoplasms; Nucleic Acids; Protein Biosynthesis; Psoriasis; Time Factors; Ultraviolet Rays | 1972 |
[Clinical picture, diagnostics and therapy of amyloidoses].
Topics: Adrenal Gland Diseases; Amyloidosis; Biopsy; Chloroquine; Chronic Disease; Gastrointestinal Diseases; Humans; Infections; Kidney Diseases; Liver Diseases; Methotrexate; Neoplasms; Pancreatic Diseases; Prognosis; Splenic Diseases | 1972 |
The emergence of drug resistance in tumours: a characteristic which may be exploited therapeutically.
Topics: Aminohydrolases; Animals; Cytarabine; Cytidine; DNA; Drug Resistance; Humans; Leukemia; Leukemia L1210; Methotrexate; Neoplasms | 1973 |
Riboflavin and cancer: a review.
Topics: Adenine Nucleotides; Animals; Azo Compounds; Benz(a)Anthracenes; Body Weight; Cells, Cultured; Epithelium; Folic Acid Antagonists; Humans; Liver; Liver Neoplasms; Methotrexate; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Riboflavin; Riboflavin Deficiency; Transplantation, Homologous | 1973 |
Recently recognized complications of cancer chemotherapy.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cyclophosphamide; Death, Sudden; Drug Therapy, Combination; Hodgkin Disease; Humans; Hyperkalemia; Infertility, Male; Lymphoma, Non-Hodgkin; Male; Mechlorethamine; Methotrexate; Neoplasms; Neoplasms, Multiple Primary; Prednisone; Procarbazine; Spermatogenesis; Vincristine | 1974 |
Predictive tests in cancer. Tuesday 9 April 1974.
Topics: Age Factors; Breast Neoplasms; Cell Movement; Clinical Enzyme Tests; Colonic Neoplasms; Cytarabine; Diagnosis, Differential; Doxorubicin; Drug Combinations; Drug Evaluation; Drug Evaluation, Preclinical; Fluorouracil; Humans; Kinetics; Leukemia; Mercaptopurine; Methods; Methotrexate; Models, Chemical; Neoplasms; Prognosis; Sarcoma; Testosterone; Thioguanine | 1974 |
Cancer chemotherapy. I.
Topics: Animals; Busulfan; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Mechlorethamine; Melphalan; Methotrexate; Mice; Neoplasms; Thiotepa | 1972 |
[Combination chemotherapy in the treatment of cancer].
Topics: Administration, Oral; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Female; Hodgkin Disease; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Ovarian Neoplasms; Procarbazine; Testicular Neoplasms; Thiotepa; Vincristine | 1972 |
Use of anticancer drugs during pregnancy.
Topics: Alkylating Agents; Aminopterin; Animals; Antimetabolites; Antineoplastic Agents; Busulfan; Chlorambucil; Choriocarcinoma; Colchicine; Female; Fetal Death; Folic Acid Antagonists; Gestational Age; Humans; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Pregnancy; Pregnancy Complications; Urethane; Vinblastine | 1968 |
[Plants with cytostatic effect].
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Nucleus; Cell Transformation, Neoplastic; Colchicine; Colchicum; DNA; Drug Synergism; Glutamine; Glycolysis; Humans; Leukemia; Mercaptopurine; Methotrexate; Mitosis; Neoplasms; Plant Extracts; Plants, Medicinal; Plants, Toxic; Podophyllum; Prednisone; Purines; Pyrimidines; RNA; Steroids; Vincristine | 1970 |
Factors pertaining to complete drug-induced remission of tumor in animals and man.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms; Nitroso Compounds; Urea | 1969 |
[Current views on drug therapy of tumors].
Topics: Animals; Antineoplastic Agents; Carcinoma, Brown-Pearce; Carcinoma, Ehrlich Tumor; Chlorambucil; Cyclophosphamide; Dactinomycin; Humans; Hyperbaric Oxygenation; Leukemia L1210; Lymphoma; Methotrexate; Mitomycins; Neoplasms; Vincristine | 1970 |
Cancer chemotherapy today and tomorrow. (A review).
Topics: Antineoplastic Agents; Child; Fluorouracil; Forecasting; Humans; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Prognosis | 1971 |
[Antimetabolites].
Topics: Allopurinol; Animals; Antimetabolites; Azathioprine; Cell Division; Chemical Phenomena; Chemistry; Cytarabine; DNA, Neoplasm; Fluorouracil; Folic Acid Antagonists; Humans; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Pyrimidines; Thioguanine | 1971 |
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
Chemotherapy and comparative biochemistry: G. H. A. Clowes memorial lecture.
Topics: Allopurinol; Animals; Antimetabolites; Azathioprine; Binding Sites; Drug Therapy; Enzyme Inhibitors; Enzyme Precursors; Folic Acid; Folic Acid Antagonists; Humans; Lactobacillus; Leukemia, Myeloid; Liver; Mercaptopurine; Methotrexate; Mice; Molecular Weight; Neoplasms; Nucleic Acids; Proteus; Purines; Research; Species Specificity; Thymine; Transferases; Uric Acid; Xanthine Oxidase | 1969 |
70 trial(s) available for methotrexate and Benign Neoplasms
| Article | Year |
|---|---|
A phase II study of concurrent involved-field radiotherapy and intrathecal chemotherapy for leptomeningeal metastasis from solid tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Methotrexate; Neoplasms | 2023 |
Phase I Study of IGF-Methotrexate Conjugate in the Treatment of Advanced Tumors Expressing IGF-1R.
Topics: Adult; Aged; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gene Expression Regulation, Neoplastic; Hematologic Neoplasms; Humans; Illinois; Kaplan-Meier Estimate; Male; Maximum Tolerated Dose; Methotrexate; Middle Aged; Molecular Targeted Therapy; Neoplasms; Patient Selection; Prognosis; Receptor, IGF Type 1; Risk Assessment; Survival Analysis | 2019 |
Safety and Efficacy of Intravenous Golimumab in Patients With Active Psoriatic Arthritis: Results Through Week Twenty-Four of the GO-VIBRANT Study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Psoriatic; Demyelinating Diseases; Double-Blind Method; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Neoplasms; Opportunistic Infections; Patient Reported Outcome Measures; Treatment Outcome | 2017 |
Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat Model.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Diarrhea; Female; Humans; Intestinal Mucosa; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Methotrexate; Neoplasms; Organic Chemicals; Random Allocation; Rats; Transplantation, Heterologous | 2018 |
The impact of prehydration on the clearance and toxicity of high-dose methotrexate for pediatric patients.
Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cross-Over Studies; Drug Monitoring; Female; Fluid Therapy; Humans; Male; Methotrexate; Neoplasms; Time Factors | 2014 |
A multicenter, open-label study of repeat courses of intramuscular alefacept in combination with other psoriasis therapies in patients with chronic plaque psoriasis.
Topics: Adult; Alefacept; CD4 Lymphocyte Count; Cyclosporine; Dermatologic Agents; Drug Administration Routes; Drug Administration Schedule; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunologic Factors; Immunosuppressive Agents; Infections; Lymphopenia; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Recombinant Fusion Proteins; Retinoids; Retreatment; Treatment Outcome; Ultraviolet Therapy | 2008 |
Route of intracerebrospinal fluid chemotherapy administration and efficacy of therapy in neoplastic meningitis.
Topics: Adult; Cytarabine; Delayed-Action Preparations; Disease-Free Survival; Humans; Injections, Intraventricular; Meningeal Carcinomatosis; Meningitis; Methotrexate; Neoplasms; Spinal Puncture | 2010 |
Continuous low-dose cyclophosphamide and methotrexate combined with celecoxib for patients with advanced cancer.
Topics: Adult; Aged; Aged, 80 and over; Angiopoietin-1; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Cyclophosphamide; Female; Humans; Male; Matrix Metalloproteinase 9; Methotrexate; Middle Aged; Neoplasms; Pyrazoles; Sulfonamides | 2011 |
Long-term safety, efficacy and inhibition of radiographic progression with abatacept treatment in patients with rheumatoid arthritis and an inadequate response to methotrexate: 3-year results from the AIM trial.
Topics: Abatacept; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunoconjugates; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Neoplasms; Opportunistic Infections; Quality of Life; Radiography; Severity of Illness Index; Treatment Failure; Treatment Outcome | 2011 |
Pilot study of a pediatric metronomic 4-drug regimen.
Topics: Administration, Metronomic; Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Male; Maximum Tolerated Dose; Methotrexate; Neoplasms; Pilot Projects; Pyrazoles; Sulfonamides; Treatment Outcome; Vinblastine; Young Adult | 2011 |
Tocilizumab inhibits structural joint damage and improves physical function in patients with rheumatoid arthritis and inadequate responses to methotrexate: LITHE study 2-year results.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Female; Health Status; Humans; Joints; Male; Methotrexate; Middle Aged; Neoplasms; Radiography; Severity of Illness Index; Sickness Impact Profile; Surveys and Questionnaires; Treatment Outcome | 2013 |
Pharmacodynamics of high-dose methotrexate in pediatric patients.
Topics: Adolescent; Adult; Algorithms; Antimetabolites, Antineoplastic; Area Under Curve; Child; Child, Preschool; Female; Fluorescence Polarization Immunoassay; Hematologic Diseases; Humans; Kidney Diseases; Linear Models; Logistic Models; Male; Methotrexate; Neoplasms; Predictive Value of Tests | 2002 |
Quality-of-life-adjusted survival comparison of sustained-release cytosine arabinoside versus intrathecal methotrexate for treatment of solid tumor neoplastic meningitis.
Topics: Adult; Cytarabine; Delayed-Action Preparations; Disease Progression; Humans; Injections, Spinal; Meningeal Neoplasms; Meningitis; Methotrexate; Neoplasms; Quality of Life; Survival Analysis | 2003 |
Relationship between myalgias/arthralgias occurring in patients receiving quinupristin/dalfopristin and biliary dysfunction.
Topics: Aged; Alkaline Phosphatase; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arthralgia; Biliary Tract Diseases; Enterococcus; Female; Gram-Positive Bacterial Infections; Humans; Immunosuppressive Agents; Liver Function Tests; Male; Methotrexate; Middle Aged; Muscular Diseases; Neoplasms; Pain; Recurrence; Risk Factors; Tacrolimus; Virginiamycin | 2004 |
Glomerular dysfunction, independent of tubular dysfunction, induced by antineoplastic chemotherapy in children.
Topics: Acute Disease; Adolescent; Albuminuria; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Creatinine; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Glomerular Filtration Rate; Humans; Kidney Tubules; Leukemia; Lymphoma; Methotrexate; Neoplasms; Neuroblastoma; Osteosarcoma; Proteinuria; Rhabdomyosarcoma; Vincristine | 2004 |
Etanercept plus standard therapy for Wegener's granulomatosis.
Topics: Cyclophosphamide; Double-Blind Method; Drug Therapy, Combination; Etanercept; Female; Glucocorticoids; Granulomatosis with Polyangiitis; Humans; Immunoglobulin G; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Neoplasms; Proportional Hazards Models; Receptors, Tumor Necrosis Factor; Remission Induction; Secondary Prevention; Treatment Failure; Tumor Necrosis Factor-alpha | 2005 |
Etanercept treatment in adults with established rheumatoid arthritis: 7 years of clinical experience.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; Humans; Immunoglobulin G; Infections; Joints; Longitudinal Studies; Male; Methotrexate; Middle Aged; Neoplasms; Receptors, Tumor Necrosis Factor; Risk; Risk Assessment; Time Factors; Treatment Outcome | 2006 |
Influence of low-energy laser in the prevention of oral mucositis in children with cancer receiving chemotherapy.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboplatin; Child; Child, Preschool; Cohort Studies; Etoposide; Female; Humans; Ifosfamide; Irinotecan; Low-Level Light Therapy; Male; Methotrexate; Mouth Mucosa; Neoplasms; Nutritional Status; Oral Hygiene; Severity of Illness Index; Stomatitis; Treatment Outcome | 2007 |
Glucarpidase (carboxypeptidase g2) intervention in adult and elderly cancer patients with renal dysfunction and delayed methotrexate elimination after high-dose methotrexate therapy.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Female; gamma-Glutamyl Hydrolase; Humans; Immunoassay; Kidney Diseases; Male; Methotrexate; Middle Aged; Neoplasms; Renal Insufficiency; Risk Factors; Time Factors; Treatment Outcome | 2007 |
Clinical application of the concept of methotrexate plus 5-FU sequence-dependent "synergy": how good is the evidence?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; DNA; Drug Synergism; Fluorouracil; Humans; Immunosuppression Therapy; Mammary Neoplasms, Experimental; Methotrexate; Mice; Neoplasms; Phosphoribosyl Pyrophosphate; Rats; RNA; Sarcoma 180; Thymidylate Synthase | 1984 |
Newer techniques in cancer chemotherapy.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Bleomycin; Bone Marrow Transplantation; Carcinoma; Cells, Cultured; Child; Cisplatin; Clinical Trials as Topic; Colonic Neoplasms; Combined Modality Therapy; Cytarabine; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Hepatic Artery; Humans; Hyperthermia, Induced; Infusions, Intra-Arterial; Leucovorin; Liver Neoplasms; Mechlorethamine; Melanoma; Meningeal Neoplasms; Methotrexate; Neoplasms; Osteosarcoma; Peritoneal Cavity; Pleura | 1984 |
Clinical trials and drug toxicity in the elderly. The experience of the Eastern Cooperative Oncology Group.
Topics: Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Fluorouracil; Hematologic Diseases; Humans; Methotrexate; Middle Aged; Neoplasms; Prognosis; Semustine | 1983 |
Combination therapy with methotrexate and 5-fluorouracil: a prospective randomized clinical trial of order of administration.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Prognosis; Random Allocation; Rectal Neoplasms; Stomach Neoplasms | 1984 |
[Clinical experiences with high-dose methotrexate].
Topics: Female; Humans; Infusions, Parenteral; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms | 1984 |
An overview of thymidine.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Clinical Trials as Topic; Cytarabine; DNA, Neoplasm; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Methylthioinosine; Mice; Neoplasms; Thymidine | 1980 |
Report on various clinical studies on high dose methotrexate in Europe (non EORTC).
Topics: Clinical Trials as Topic; Europe; Female; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma | 1981 |
Dose dependent methotrexate elimination following bolus intravenous injection.
Topics: Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Kidney; Male; Metabolic Clearance Rate; Methotrexate; Neoplasms | 1980 |
Pharmacologic-guided trial of sequential methotrexate and thioguanine in children with advanced malignancies.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Leukemia; Lymphoma; Male; Methotrexate; Neoplasms; Phosphoribosyl Pyrophosphate; Remission Induction; Thioguanine | 1994 |
The use of G-CSF or GM-CSF mobilized peripheral blood progenitor cells (PBPC) alone or to augment marrow as hematologic support of single or multiple cycle high-dose chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Bone Marrow Transplantation; Breast Neoplasms; Carboplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Graft Survival; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Leukapheresis; Male; Melphalan; Methotrexate; Middle Aged; Neoplasms; Neutropenia; Salvage Therapy; Treatment Outcome | 1993 |
Reduction of the systemic toxicity of cisplatin by intra-arterial hepatic route administration for liver malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Kidney Diseases; Leucovorin; Liver; Liver Neoplasms; Methotrexate; Neoplasms; Nervous System Diseases; Ovarian Neoplasms; Remission Induction; Spectrophotometry, Atomic; Tumor Cells, Cultured; Vinblastine | 1995 |
The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data.
Topics: Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms; Phosphonoacetic Acid; Trimetrexate | 1994 |
Efficacy of oral ondansetron, a selective antagonist of 5-HT3 receptors, in the treatment of nausea and vomiting associated with cyclophosphamide-based chemotherapies. Ondansetron Study Group.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Drug; Double-Blind Method; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Nausea; Neoplasms; Ondansetron; Treatment Outcome; Vomiting | 1994 |
Bioequivalence of two methotrexate formulations in psoriatic and cancer patients.
Topics: Adult; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drugs, Generic; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Tablets; Therapeutic Equivalency | 1993 |
5-fluorouracil modulates the toxicity of high dose methotrexate.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasms | 1995 |
A phase I study of methotrexate administration following 5-fluorouracil.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasms; Survival Rate | 1996 |
A phase I trial of a modified, dose intensive FAMTX regimen (high dose 5-fluorouracil+doxorubicin+high dose methotrexate+leucovorin) with oral uridine rescue.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Leucovorin; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasms; Neutropenia; Uridine | 1996 |
A phase I investigation of the sequential use of methotrexate and paclitaxel with and without G-CSF for the treatment of solid tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Drug Synergism; Granulocyte Colony-Stimulating Factor; Head and Neck Neoplasms; Humans; Infusions, Intravenous; Lung Neoplasms; Methotrexate; Middle Aged; Neoplasms; Paclitaxel | 1996 |
Oral ondansetron 8 mg twice daily is as effective as 8 mg three times daily in the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy. S3A-376 Study Group.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Appetite; Cyclophosphamide; Double-Blind Method; Doxorubicin; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Nausea; Neoplasms; Ondansetron; Time Factors; Vomiting | 1997 |
High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary?
Topics: Adult; Antimetabolites, Antineoplastic; Arachnoid Cysts; Female; Humans; Infusions, Intravenous; Injections, Spinal; Male; Methotrexate; Middle Aged; Neoplasms; Survival Analysis | 1998 |
Phase I trial of methotrexate-albumin in a weekly intravenous bolus regimen in cancer patients. Phase I Study Group of the Association for Medical Oncology of the German Cancer Society.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Dose-Response Relationship, Drug; Female; Humans; Kidney Neoplasms; Male; Mesothelioma; Methotrexate; Middle Aged; Neoplasms; Pleural Neoplasms; Remission Induction; Serum Albumin; Spinal Cord Neoplasms | 1999 |
A randomized controlled trial comparing intrathecal sustained-release cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cytarabine; Delayed-Action Preparations; Disease Progression; Female; Humans; Injections, Spinal; Lung Neoplasms; Male; Melanoma; Meningeal Neoplasms; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Survival Rate; Survivors | 1999 |
Rapid achievement of complete donor chimerism and low regimen-related toxicity after reduced conditioning with fludarabine, carmustine, melphalan and allogeneic transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclosporine; Female; Follow-Up Studies; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Leukapheresis; Male; Melphalan; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Survival Analysis; T-Lymphocytes; Transplantation Chimera; Transplantation Conditioning; Transplantation Tolerance; Vidarabine | 2000 |
Phase I pharmacokinetic and sequence finding study of the combination of docetaxel and methotrexate in patients with solid tumours.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Synergism; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Paclitaxel; Taxoids | 2002 |
Recovery from toxicity associated with high-dose methotrexate: prognostic factors.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dehydration; Drug Therapy, Combination; Female; Hematologic Diseases; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Infant; Kidney Diseases; Kidney Function Tests; Leucovorin; Liver Diseases; Liver Function Tests; Male; Methotrexate; Neoplasms; Pleural Effusion; Prognosis; Time Factors; Vomiting | 1977 |
How strong is the case for intensive cancer chemotherapy?
Topics: Antineoplastic Agents; Burkitt Lymphoma; Clinical Trials as Topic; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administration Schedule; Head and Neck Neoplasms; Humans; Lung Neoplasms; Mechlorethamine; Methotrexate; Neoplasms | 1976 |
High-dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations and corrective measures to avert toxicity.
Topics: Bicarbonates; Drug Interactions; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Time Factors | 1977 |
Phase I trial of combination methotrexate and methyl-CCNU in patients with advanced neoplastic diseases.
Topics: Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Methotrexate; Neoplasms; Nitrosourea Compounds; Semustine; Time Factors | 1977 |
Phase I trial of high-dose methotrexate with modified citrovorum factor rescue.
Topics: Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Middle Aged; Neoplasms; Time Factors | 1978 |
Phase II clinical trial with high-dose methotrexate therapy and citrovorum factor rescue.
Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Drug Evaluation; Humans; Infusions, Parenteral; Leucovorin; Methotrexate; Middle Aged; Neoplasms | 1978 |
A Phase 1 study of high doses of aminopterin with leucovorin rescue in patients with advanced metastatic tumors.
Topics: Aminopterin; Bone Marrow; Clinical Trials as Topic; Drug Administration Schedule; Humans; Kidney; Leucovorin; Leukopenia; Methotrexate; Neoplasm Metastasis; Neoplasms; Solubility | 1979 |
Hexamethylmelamine, vincristine, and methotrexate chemotherapy in advanced neoplasms.
Topics: Adult; Aged; Altretamine; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Methotrexate; Middle Aged; Neoplasms; Time Factors; Triazines; Vincristine | 1977 |
Enhancement of methotrexate absorption by subdivision of dose.
Topics: Half-Life; Humans; Intestinal Absorption; Methotrexate; Neoplasms; Time Factors | 1979 |
[Sequential chemotherapy based on the hypothesis of a circadian rhythm of tumor proliferation].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Circadian Rhythm; Clinical Trials as Topic; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Granulocytes; Humans; Male; Methotrexate; Middle Aged; Mitosis; Neoplasm Metastasis; Neoplasms; Remission, Spontaneous; Vinblastine | 1975 |
Quality of life measurements in anti-emetic trials: a discussion of Professor Selby's paper.
Topics: Antiemetics; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Fluorouracil; Humans; Male; Methotrexate; Neoplasms; Palliative Care; Quality of Life; Research Design | 1992 |
Relative importance of dose, body surface area, sex, and age for 5-fluorouracil clearance.
Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Body Surface Area; Breast Neoplasms; Colonic Neoplasms; Esophageal Neoplasms; Female; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Neoplasms; Rectal Neoplasms; Sex Characteristics | 1991 |
Conditioning-related toxicity and acute graft-versus-host disease in patients given methotrexate/cyclosporine prophylaxis.
Topics: Acute Disease; Antineoplastic Agents; Bone Marrow Transplantation; Combined Modality Therapy; Cyclosporins; Graft vs Host Disease; Humans; Methotrexate; Neoplasms | 1991 |
Intracavitary chemotherapy.
Topics: Anthraquinones; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Catheters, Indwelling; Cisplatin; Clinical Trials as Topic; Cytarabine; Doxorubicin; Etoposide; Fluorouracil; Humans; Immunotherapy; Infusions, Parenteral; Melphalan; Methotrexate; Mitomycins; Mitoxantrone; Neoplasms; Organoplatinum Compounds | 1986 |
Oral dipyridamole and methotrexate in human solid tumors: a toxicity trial.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Humans; Injections, Intramuscular; Injections, Intravenous; Methotrexate; Neoplasms; Time Factors | 1989 |
The effects of diltiazem on methotrexate-induced nephrotoxicity.
Topics: Acute Kidney Injury; Adult; Diltiazem; Diuresis; Drug Interactions; Humans; Kidney Function Tests; Methotrexate; Middle Aged; Neoplasms; Randomized Controlled Trials as Topic | 1989 |
Clinical pharmacology of oral intermediate-dose methotrexate with or without probenecid.
Topics: Administration, Oral; Clinical Trials as Topic; Drug Administration Schedule; Humans; Methotrexate; Neoplasms; Probenecid | 1985 |
Toxicity of low dose methotrexate in rheumatoid arthritis.
Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infertility, Female; Infertility, Male; Kidney Diseases; Lung Diseases; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Random Allocation; Risk; Skin Diseases | 1985 |
Low dosage methotrexate (NSC-740) and cyclophosphamide (NSC 26271) for solid tumors.
Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Cyclophosphamide; Drug Combinations; Female; Humans; Laryngeal Neoplasms; Lung Neoplasms; Male; Melanoma; Methotrexate; Middle Aged; Nausea; Neoplasms; Radiography; Rectal Neoplasms; Stomatitis; Wilms Tumor | 1970 |
Immunologic suppression by methotrexate in dermatology.
Topics: Adult; Clinical Trials as Topic; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Immunosuppression Therapy; Methotrexate; Middle Aged; Neoplasms; Pemphigus; Psoriasis; Skin Diseases; Skin Tests | 1972 |
[Polychemotherapy of malignant neoplasms].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Cyclophosphamide; Female; Fluorouracil; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasms; Procarbazine; Vinblastine | 1972 |
Combined radiotherapy and chemotherapy for treatment of unresectable and or metastatic cancer.
Topics: Aged; Breast Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms; Phosphorus Radioisotopes; Remission, Spontaneous; Vincristine | 1974 |
Combination chemotherapy in disseminated solid tumours.
Topics: Clinical Trials as Topic; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fluorouracil; Humans; Kidney; Leukocyte Count; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms; Vincristine | 1974 |
[Intermittent cytostatic intensive therapy of solid tumors with a combination of four drugs].
Topics: Adult; Aged; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunity, Cellular; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Neoplasms; Remission, Spontaneous; Vinblastine | 1973 |
Combination chemotherapy for 418 cases of advanced cancer.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Clinical Trials as Topic; Cyclophosphamide; Drug Synergism; Female; Fluorouracil; History, 16th Century; Humans; Hydrazines; Injections, Intravenous; Laryngeal Neoplasms; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasms; Prognosis; Time Factors; Tongue Neoplasms; Vinblastine | 1971 |
The chemotherapy of human and animal acute leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Cell Division; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Disease Models, Animal; Drug Combinations; Humans; Kinetics; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Remission, Spontaneous; RNA, Neoplasm; Vincristine | 1971 |
Pharmacologic studies of methotrexate in cancer patients with uropathy.
Topics: Colonic Neoplasms; Humans; Injections, Intravenous; Kidney Diseases; Kidney Function Tests; Methotrexate; Neoplasms; Pelvic Neoplasms; Tritium | 1970 |
896 other study(ies) available for methotrexate and Benign Neoplasms
| Article | Year |
|---|---|
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid; Folic Acid Antagonists; Humans; Liver; Methotrexate; Molecular Structure; Neoplasms; Pneumocystis; Rats; Recombinant Proteins; Structure-Activity Relationship; Thymidylate Synthase; Toxoplasma; Tumor Cells, Cultured | 1994 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Male; Mice, Inbred BALB C; Molecular Docking Simulation; Neoplasms; Tetrahydrofolate Dehydrogenase; Triazines | 2017 |
Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase.
Topics: Antineoplastic Agents; Cell Cycle; Diamines; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Neoplasms; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 2017 |
Three-component synthesis of chromeno β-lactam hybrids for inflammation and cancer screening.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Benzopyrans; beta-Lactams; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Inflammation; Mice; Molecular Structure; Neoplasms; RAW 264.7 Cells; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Methionine synthase is essential for cancer cell proliferation in physiological folate environments.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Methotrexate; Neoplasms; Tetrahydrofolates | 2021 |
Clinical utility of intralesional methotrexate to distinguish crateriform keratinocytic tumors before surgery.
Topics: Humans; Injections, Intralesional; Keratinocytes; Keratoacanthoma; Methotrexate; Neoplasms | 2022 |
Incidence and management of patients with methotrexate delayed elimination in the clinical practice: A Delphi study.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Child; Delphi Technique; Drug-Related Side Effects and Adverse Reactions; Humans; Incidence; Methotrexate; Neoplasms | 2023 |
COVID-19 outcomes in patients with cancer: Findings from the University of California health system database.
Topics: Adult; COVID-19; COVID-19 Testing; Hospitalization; Humans; Methotrexate; Neoplasms; Retrospective Studies; SARS-CoV-2 | 2022 |
Evaluation of kidney dysfunction in childhood cancer survivors.
Topics: Acute Kidney Injury; Biomarkers; Cancer Survivors; Child; Cisplatin; Creatinine; Cross-Sectional Studies; Cystatin C; Humans; Kidney; Lipocalin-2; Methotrexate; Neoplasms; Renal Insufficiency | 2022 |
Heterocyclic Compounds: Importance in Anticancer Drug Discovery.
Topics: Antineoplastic Agents; Daunorubicin; Doxorubicin; Fluorouracil; Heterocyclic Compounds; Humans; Methotrexate; Neoplasms; Pharmaceutical Preparations; Vinblastine; Vincristine | 2022 |
Regulation of Nucleotide Metabolism with Nutrient-Sensing Nanodrugs for Cancer Therapy.
Topics: Animals; Carbon; DNA; Histidine; Humans; Methotrexate; Mice; Nanoparticles; Neoplasms; Nucleotides; Nutrients; RNA | 2022 |
Antioxidant nutrients can increase high-dose Methotrexate efficacy in 4T1 breast tumor Model: An experimental study on Vitamin E Succinate and Methyl-selenic acid.
Topics: alpha-Tocopherol; Animals; Antioxidants; Forkhead Transcription Factors; Methotrexate; Mice; Neoplasms; Nutrients; Selenic Acid; Vascular Endothelial Growth Factor A | 2022 |
Design of ROS-Responsive Hyaluronic Acid-Methotrexate Conjugates for Synergistic Chemo-Photothermal Therapy for Cancer.
Topics: Animals; Cell Line, Tumor; Doxorubicin; Hyaluronic Acid; Hyperthermia, Induced; Methotrexate; Mice; Nanoparticles; Neoplasms; Phototherapy; Photothermal Therapy; Reactive Oxygen Species | 2022 |
Galactomannan armed superparamagnetic iron oxide nanoparticles as a folate receptor targeted multi-functional theranostic agent in the management of cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Folic Acid; Galactose; Humans; Magnetic Iron Oxide Nanoparticles; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mannans; Methotrexate; Mice; Nanoparticles; Neoplasms; Theranostic Nanomedicine | 2022 |
Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage.
Topics: Cell Line; Cell Membrane; Electromagnetic Fields; Humans; Magnetic Fields; Methotrexate; Neoplasms | 2022 |
Insights from a pharmacometric analysis of HDMTX in adults with cancer: Clinically relevant covariates for application in precision dosing.
Topics: Acute Kidney Injury; Adult; Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neoplasms; Seizures | 2023 |
Iron-based nanoscale coordination polymers synergistically induce immunogenic ferroptosis by blocking dihydrofolate reductase for cancer immunotherapy.
Topics: Ferroptosis; Humans; Immunotherapy; Iron; Methotrexate; Neoplasms; Polymers; Tetrahydrofolate Dehydrogenase; Tumor Microenvironment | 2022 |
Risk of malignancy in patients with psoriasis receiving systemic medications: A nested case-control study.
Topics: Adalimumab; Biological Products; Case-Control Studies; Cyclosporine; Dermatologic Agents; Etanercept; Humans; Methotrexate; Neoplasms; Psoriasis; Ustekinumab | 2022 |
Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy.
Topics: Animals; Antioxidants; Choroid Plexus; Hippocampus; Humans; Methotrexate; Mice; Neoplasms; Oxidative Stress | 2022 |
Hydrogen Bond-Mediated Supramolecular Polymeric Nanomedicine with pH/Light-Responsive Methotrexate Release and Synergistic Chemo-/Photothermal Therapy.
Topics: Doxorubicin; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hyperthermia, Induced; Methotrexate; Micelles; Nanomedicine; Neoplasms; Photothermal Therapy; Polymers; Theranostic Nanomedicine | 2022 |
Examining the potential direct cardiovascular benefit of tumor-necrosis factor inhibitor in rheumatoid arthritis: Natural and controlled direct effect analyses.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Humans; Methotrexate; Necrosis; Neoplasms; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha | 2023 |
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biosimilar Pharmaceuticals; Drug Therapy, Combination; Humans; Methotrexate; Neoplasms | 2023 |
Tumor Targeting with Methotrexate-Conjugated Zwitterionic Near-Infrared Fluorophore for Precise Photothermal Therapy.
Topics: Antineoplastic Agents; Fluorescent Dyes; Humans; Ionophores; Methotrexate; Neoplasms; Photothermal Therapy | 2022 |
Genetic variants found in paediatric oncology patients with severe chemotherapy-induced toxicity: A case series.
Topics: Antineoplastic Agents; Child; Genotype; Humans; Methotrexate; Neoplasms; Pharmacogenetics | 2023 |
Ultrasensitive therapeutic drug monitoring of methotrexate by a structure-switching aptamer with cascade primer exchange reaction.
Topics: Drug Monitoring; Humans; Methotrexate; Neoplasms; Oligonucleotides | 2023 |
Successful treatment of pure red cell aplasia induced by anti-PD-1 tslelizumab with low-dose methotrexate for metastatic urothelial cancer.
Topics: Humans; Immunosuppressive Agents; Methotrexate; Neoplasms; Red-Cell Aplasia, Pure | 2023 |
Drug Encapsulated Lipid-Polymeric Nanohybrid as a Chemo-therapeutic Platform of Cancer.
Topics: Humans; Methotrexate; Neoplasms; Pharmaceutical Preparations; Phosphatidylcholines; Polymers; Reactive Oxygen Species | 2023 |
How Does the Study MD of pH-Dependent Exposure of Nanoparticles Affect Cellular Uptake of Anticancer Drugs?
Topics: Antineoplastic Agents; Drug Carriers; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Lipid Bilayers; Methotrexate; Molecular Dynamics Simulation; Nanoparticles; Neoplasms | 2023 |
Efficient synthesis and anticancer evaluation of spider toxin peptide LVTX-8-based analogues with enhanced stability.
Topics: Antineoplastic Agents; Cell-Penetrating Peptides; Humans; Methotrexate; Neoplasms; Spider Venoms | 2023 |
Synthesis, characterization, and in vitro anti-tumor activity studies of the hyaluronic acid-mangiferin-methotrexate nanodrug targeted delivery system.
Topics: Cell Line, Tumor; Drug Delivery Systems; Humans; Hyaluronic Acid; Ligands; Methotrexate; Nanoparticle Drug Delivery System; Nanoparticles; Neoplasms; Spectroscopy, Fourier Transform Infrared | 2023 |
Synthesis of Zeolitic imidazolate frameworks-8@ layered double hydroxide polyhedral nanocomposite with designed porous voids as an effective carrier for anti-cancer drug-controlled delivery.
Topics: Antineoplastic Agents; Humans; Hydroxides; Methotrexate; Nanocomposites; Neoplasms; Porosity; Zeolites | 2023 |
In-vivo anticancer efficacy of self-targeted methotrexate-loaded polymeric nanoparticles in solid tumor-bearing rat.
Topics: Animals; Chitosan; Drug Carriers; Methotrexate; Nanoparticles; Neoplasms; Rats | 2023 |
Histochemical, Immunohistochemical, and Biochemical Investigation of the Effect of Resveratrol on Testicular Damage Caused by Methotrexate (MTX).
Topics: Animals; Antioxidants; Biomarkers; Male; Methotrexate; Neoplasms; Oxidative Stress; Rats; Rats, Wistar; Resveratrol; Serum Albumin; Sulfhydryl Compounds | 2023 |
A novel thermoresponsive nano carrier matrix of hyaluronic acid, methotrexate and chitosan to target the cluster of differentiation 44 receptors in tumors.
Topics: Chitosan; Humans; Hyaluronic Acid; Methotrexate; Nanoparticles; Neoplasms | 2023 |
Use of Immunosuppression and the Risk of Subsequent Overall or Cancer Mortality.
Topics: Adalimumab; Alkylating Agents; Antimetabolites; Azathioprine; Calcineurin Inhibitors; Cohort Studies; Cyclosporine; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Infliximab; Methotrexate; Mycophenolic Acid; Neoplasms; Retrospective Studies; Tumor Necrosis Factor Inhibitors | 2023 |
Is Methotrexate Ototoxic? Investigating the Ototoxic Late Effects of Pediatric Cancer Treatment.
Topics: Antineoplastic Agents; Child; Cisplatin; Deafness; Hearing Loss; Humans; Methotrexate; Neoplasms; Ototoxicity; Retrospective Studies | 2023 |
Fluorescent immunochromatographic test strip for therapeutic drug monitoring of methotrexate with high sensitivity and wide dynamic range.
Topics: Drug Monitoring; Humans; Methotrexate; Microspheres; Neoplasms; Reproducibility of Results | 2023 |
Risks of malignant lymphoma in rheumatoid arthritis patients receiving methotrexate-alone and in combination therapy compared with the general population: A study based on a Japanese medical claims database.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; East Asian People; Humans; Lymphoma; Methotrexate; Neoplasms; Retrospective Studies; Treatment Outcome | 2023 |
Wearable Microneedle-Based Array Patches for Continuous Electrochemical Monitoring and Drug Delivery: Toward a Closed-Loop System for Methotrexate Treatment.
Topics: Chitosan; Humans; Methotrexate; Needles; Neoplasms; Wearable Electronic Devices | 2023 |
Caffeine-folic acid-loaded-chitosan nanoparticles combined with methotrexate as a novel HepG2 immunotherapy targeting adenosine A2A receptor downstream cascade.
Topics: Adenosine; Caffeine; Chitosan; Folic Acid; Humans; Immunotherapy; Methotrexate; Molecular Docking Simulation; Nanoparticles; Neoplasms; Receptor, Adenosine A2A; Tumor Microenvironment | 2023 |
Recurrence of Metastatic Crohn's Disease after Surgical Resection.
Topics: Abscess; Adult; Crohn Disease; Female; Humans; Infliximab; Mercaptopurine; Methotrexate; Neoplasms; Recurrence | 2023 |
In-vitro and in-vivo assessment of pH-responsive core-shell nanocarrier system for sequential delivery of methotrexate and 5-fluorouracil for the treatment of breast cancer.
Topics: Animals; Drug Carriers; Female; Fluorouracil; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles; Neoplasms | 2023 |
Identification of methotrexate as a heterochromatin-promoting drug.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; Chromatin Assembly and Disassembly; Color; Drosophila melanogaster; Drosophila Proteins; Epigenesis, Genetic; Eye; Female; Genetic Variation; Genomic Instability; Heterochromatin; High-Throughput Screening Assays; Histones; Humans; Janus Kinases; Male; Methotrexate; Models, Biological; Neoplasms; Phosphorylation; Pigmentation; Small Molecule Libraries; STAT Transcription Factors; Transcription Factors | 2019 |
NIR- and thermo-responsive semi-interpenetrated polypyrrole nanogels for imaging guided combinational photothermal and chemotherapy.
Topics: A549 Cells; Animals; Antineoplastic Agents; Contrast Media; Diagnostic Imaging; Drug Delivery Systems; Female; Hot Temperature; Humans; Methotrexate; Mice, Nude; Nanogels; Neoplasms; Photoacoustic Techniques; Phototherapy; Polymers; Pyrroles | 2019 |
Low-dose methotrexate: potential clinical impact on haematological and constitutional symptoms in myeloproliferative neoplasms.
Topics: Aged, 80 and over; Apatites; Carbonates; Comorbidity; Female; Humans; Male; Methotrexate; Middle Aged; Myeloproliferative Disorders; Neoplasms; Treatment Outcome | 2019 |
Population pharmacokinetic analysis of high-dose methotrexate in pediatric and adult oncology patients.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Glomerular Filtration Rate; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Models, Biological; Neoplasms; Young Adult | 2019 |
Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents.
Topics: Antineoplastic Agents; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Doxorubicin; Fluorouracil; Humans; Irinotecan; Methotrexate; Neoplasms; Oxaliplatin; Paclitaxel; Phenotype; Tumor Cells, Cultured | 2019 |
Association between malignancy and methotrexate and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis
.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Neoplasms; Treatment Outcome | 2020 |
Tumor microenvironment-activated self-recognizing nanodrug through directly tailored assembly of small-molecules for targeted synergistic chemotherapy.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Delivery Systems; Humans; Methotrexate; Nanoparticles; Neoplasms; Tumor Microenvironment | 2020 |
Self-assembled peptide nanoparticles for efficient delivery of methotrexate into cancer cells.
Topics: Antineoplastic Agents; Cell Membrane Permeability; Cell-Penetrating Peptides; Drug Carriers; Drug Screening Assays, Antitumor; Humans; Hydrophobic and Hydrophilic Interactions; MCF-7 Cells; Methotrexate; Nanoparticles; Neoplasms; Toxicity Tests, Acute | 2020 |
Evaluation of methotrexate clearance with an enteral urine alkalinization protocol for patients receiving high-dose methotrexate.
Topics: Adult; Aged; Alkalies; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Endpoint Determination; Female; Humans; Infusions, Parenteral; Length of Stay; Male; Methotrexate; Middle Aged; Neoplasms; Retrospective Studies; Sodium Bicarbonate | 2021 |
Tumor-Specific Endogenous Fe
Topics: Animals; Antineoplastic Agents; Artesunate; Cell Line, Tumor; Cell Survival; Drug Carriers; Ferrous Compounds; Gadolinium; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Imaging; Methotrexate; Mice; Mice, Nude; Nanoparticles; Neoplasms; Rats; Reactive Oxygen Species; Theranostic Nanomedicine; Xenograft Model Antitumor Assays | 2020 |
Nitrous oxide (N2O) angel or devil?
Topics: Humans; Medical Oncology; Methotrexate; Neoplasms; Nitrous Oxide | 2020 |
EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.
Topics: Advisory Committees; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthralgia; Arthritis, Psoriatic; Arthritis, Reactive; Autoantibodies; Decision Making, Shared; Deprescriptions; Europe; Glucocorticoids; Humans; Immune Checkpoint Inhibitors; Immunoglobulins, Intravenous; Immunologic Factors; Medical Oncology; Methotrexate; Myalgia; Myocarditis; Myositis; Neoplasms; Plasma Exchange; Polymyalgia Rheumatica; Rheumatic Diseases; Rheumatology; Severity of Illness Index; Societies, Medical; Tumor Necrosis Factor Inhibitors | 2021 |
Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy.
Topics: Drug Delivery Systems; Gold; Humans; Metal Nanoparticles; Methotrexate; Neoplasms; Reactive Oxygen Species | 2020 |
A single-center qualitative study evaluating the safety and efficacy of a pharmacist-driven protocol for high-dose methotrexate management.
Topics: Acute Kidney Injury; Aged; Antimetabolites; Cohort Studies; Female; Guideline Adherence; Humans; Incidence; Length of Stay; Male; Medication Therapy Management; Methotrexate; Middle Aged; Neoplasms; Pharmacists; Retrospective Studies; Treatment Outcome | 2021 |
Ultralong-Circulating and Self-Targeting "Watson-Crick A = T"-Inspired Supramolecular Nanotheranostics for NIR-II Imaging-Guided Photochemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Clofarabine; Drug Liberation; Humans; Indocyanine Green; Infrared Rays; Macromolecular Substances; Methotrexate; Mice; Neoplasms; Optical Imaging; Particle Size; Photochemotherapy; Surface Properties; Theranostic Nanomedicine; Tumor Cells, Cultured | 2020 |
In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics.
Topics: Area Under Curve; Binding Sites; Catalytic Domain; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Hydrogen Bonding; Ligands; Methotrexate; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Neoplasms; ROC Curve; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2020 |
Self-Assemble Amphiphilic PEO-PPO-PEO Tri-Block Co-Polymeric Methotrexate Nanomicelles to Combat MCF7 Cancer Cells.
Topics: Drug Carriers; Humans; MCF-7 Cells; Methotrexate; Micelles; Neoplasms; Particle Size; Poloxamer; Polyethylene Glycols; Polymers; Propylene Glycols | 2021 |
Methotrexate-Induced Acute Rheumatoid Nodulosis in Liver and Spleen Imitating Metastatic Malignancy.
Topics: Antirheumatic Agents; Humans; Liver; Methotrexate; Neoplasms; Rheumatoid Nodule; Spleen | 2021 |
Immune checkpoint-mediated psoriasis: A multicenter European study of 115 patients from the European Network for Cutaneous Adverse Event to Oncologic Drugs (ENCADO) group.
Topics: Acitretin; Aged; Biological Products; Dermatologic Agents; Drug Therapy, Combination; Europe; Female; Follow-Up Studies; Glucocorticoids; Humans; Immune Checkpoint Inhibitors; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Retrospective Studies; Severity of Illness Index; Thalidomide; Treatment Outcome | 2021 |
MTX-Loaded Dual Thermoresponsive and pH-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer.
Topics: Acrylamides; Antineoplastic Agents; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Liberation; Humans; Hydrogels; Hydrogen-Ion Concentration; Hyperthermia; Magnetite Nanoparticles; MCF-7 Cells; Methacrylates; Methotrexate; Nanocomposites; Nanogels; Neoplasms; Particle Size; Polymers; Spectroscopy, Fourier Transform Infrared | 2021 |
Nanoparticles Incorporating a Fluorescence Turn-on Reporter for Real-Time Drug Release Monitoring, a Chemoenhancer and a Stealth Agent: Poseidon's Trident against Cancer?
Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Drug Liberation; Fluorescence; Graphite; Humans; Methotrexate; Mice; Nanoparticles; Nanotubes, Carbon; Neoplasms; RAW 264.7 Cells | 2021 |
Risk of solid cancers overall and by subtypes in patients with psoriatic arthritis treated with TNF inhibitors - a Nordic cohort study.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Cohort Studies; Female; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Proportional Hazards Models; Registries; Risk Factors; Scandinavian and Nordic Countries; Tumor Necrosis Factor Inhibitors | 2021 |
Direct control of CAR T cells through small molecule-regulated antibodies.
Topics: Animals; Antigens, Neoplasm; Cell Line, Tumor; Combined Modality Therapy; Female; HEK293 Cells; Humans; Immunotherapy, Adoptive; Methotrexate; Mice; Neoplasms; Primary Cell Culture; Receptors, Chimeric Antigen; Single-Domain Antibodies; T-Cell Antigen Receptor Specificity; T-Lymphocytes; Xenograft Model Antitumor Assays | 2021 |
Low Serum Albumin Level Is a Risk Factor for Delayed Methotrexate Elimination in High-Dose Methotrexate Treatment.
Topics: Humans; Methotrexate; Neoplasms; Retrospective Studies; Risk Factors; Serum Albumin | 2021 |
UK paediatric oncology
Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antimetabolites, Antineoplastic; Child; Child, Preschool; Humans; Incidence; Infant; Ireland; Methotrexate; Neoplasms; Pneumocystis carinii; Pneumonia, Pneumocystis; Population Surveillance; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Trimethoprim, Sulfamethoxazole Drug Combination; United Kingdom | 2021 |
Development of an albumin decorated lipid-polymer hybrid nanoparticle for simultaneous delivery of methotrexate and conferone to cancer cells.
Topics: Albumins; Coumarins; Drug Carriers; Lipids; Methotrexate; Nanoparticles; Neoplasms; Polyethylene Glycols; Polymers | 2021 |
Folate transporter dynamics and therapy with classic and tumor-targeted antifolates.
Topics: Biological Transport; Cell Proliferation; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Methotrexate; Neoplasms; Ornithine; Pemetrexed; Proton-Coupled Folate Transporter; Pterins; Reduced Folate Carrier Protein | 2021 |
A minimal physiologically based pharmacokinetic model for high-dose methotrexate.
Topics: Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Kidney; Male; Methotrexate; Models, Biological; Neoplasms | 2021 |
[Acute renal failure and cancer treatment].
Topics: Acute Kidney Injury; Humans; Kidney; Methotrexate; Neoplasms; Thrombotic Microangiopathies | 2021 |
Light/magnetic hyperthermia triggered drug released from multi-functional thermo-sensitive magnetoliposomes for precise cancer synergetic theranostics.
Topics: A549 Cells; Animals; Antimetabolites, Antineoplastic; Female; HeLa Cells; Humans; Hyperthermia, Induced; Iron; Light; Liposomes; Magnetic Fields; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms; Oleic Acid; Rats, Sprague-Dawley; Theranostic Nanomedicine | 2018 |
Low-dose methotrexate in myeloproliferative neoplasm models.
Topics: Animals; Humans; Methotrexate; Mice; Myeloproliferative Disorders; Neoplasms; Phosphorylation; STAT3 Transcription Factor; STAT5 Transcription Factor | 2017 |
Bio-stimuli-responsive multi-scale hyaluronic acid nanoparticles for deepened tumor penetration and enhanced therapy.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dendrimers; Drug Carriers; Hyaluronic Acid; Male; Methotrexate; Mice; Mice, Nude; Nanoparticles; Neoplasms | 2017 |
Outcomes of matched sibling donor bone marrow transplantation in children using single-agent calcineurin inhibitors as prophylaxis for graft versus host disease.
Topics: Adolescent; Allografts; Bone Marrow Transplantation; Calcineurin Inhibitors; Child; Child, Preschool; Female; Graft vs Host Disease; Histocompatibility Testing; Humans; Infant; Male; Methotrexate; Neoplasms; Retrospective Studies; Siblings; Tissue Donors | 2018 |
Methotrexate and epirubicin conjugates as potential antitumor drugs.
Topics: Antineoplastic Agents; Drug Design; Epirubicin; Humans; Mass Spectrometry; Methotrexate; Neoplasms | 2017 |
Risk of malignancy with systemic psoriasis treatment in the Psoriasis Longitudinal Assessment Registry.
Topics: Adult; Age Distribution; Aged; Biological Products; Case-Control Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Incidence; Logistic Models; Longitudinal Studies; Male; Methotrexate; Middle Aged; Multivariate Analysis; Neoplasms; Prognosis; Psoriasis; Registries; Risk Assessment; Severity of Illness Index; Sex Distribution; Tumor Necrosis Factor-alpha; Ustekinumab | 2017 |
A single center retrospective analysis of a protocol for high-dose methotrexate and leucovorin rescue administration.
Topics: Adult; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid Antagonists; Guideline Adherence; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Outcome Assessment, Health Care; Retrospective Studies; United States | 2019 |
Programmed Nanococktail Based on pH-Responsive Function Switch for Self-Synergistic Tumor-Targeting Therapy.
Topics: Antineoplastic Agents; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles; Neoplasms; Polyethylene Glycols; Prodrugs | 2017 |
Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Consensus; Dose-Response Relationship, Drug; Follow-Up Studies; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Neoplasms; Practice Guidelines as Topic; Recombinant Proteins | 2018 |
Hispanic ethnicity as a risk factor for requiring glucarpidase rescue in pediatric patients receiving high-dose methotrexate.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; gamma-Glutamyl Hydrolase; Hispanic or Latino; Humans; Male; Methotrexate; Neoplasms; Risk Factors | 2018 |
Chinese Registry of rheumatoid arthritis (CREDIT): II. prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cardiovascular Diseases; China; Comorbidity; Female; Fractures, Bone; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Neoplasms; Prevalence; Registries; Risk Factors | 2017 |
Dual-drug loaded nanoneedles with targeting property for efficient cancer therapy.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Survival; Drug Carriers; Drug Liberation; Drug Synergism; HeLa Cells; Humans; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Scanning; Nanoparticles; Neoplasms; Polyethylene Glycols; Polyglactin 910; Tissue Distribution; Transplantation, Heterologous | 2017 |
Developing single-entity theranostic: drug-based fluorescent nanoclusters with augmented cytotoxicity.
Topics: Apoptosis; Cell Proliferation; Cell Survival; Chitosan; Drug Delivery Systems; Gold; HeLa Cells; Humans; Metal Nanoparticles; Methotrexate; Neoplasms; Theranostic Nanomedicine | 2018 |
Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin.
Topics: Adoptive Transfer; ADP Ribose Transferases; Animals; Antibodies, Monoclonal; Antibody Formation; Bacterial Toxins; Cells, Cultured; Exotoxins; Female; GPI-Linked Proteins; Immune Tolerance; Immunity, Humoral; Immunotherapy; Immunotoxins; Mesothelin; Methotrexate; Mice; Mice, Inbred BALB C; Neoplasms; Pseudomonas aeruginosa Exotoxin A; Recombinant Proteins; Virulence Factors | 2018 |
Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Colloids; Curcumin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Endocytosis; HeLa Cells; Humans; Hydrodynamics; Hydrogen-Ion Concentration; MCF-7 Cells; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Micelles; Nanoparticles; Neoplasms; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Prodrugs | 2018 |
Comparative Proteomics of Dying and Surviving Cancer Cells Improves the Identification of Drug Targets and Sheds Light on Cell Life/Death Decisions.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Survival; Fluorouracil; Humans; Methotrexate; Neoplasms; Paclitaxel; Proteome; Proteomics | 2018 |
Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment.
Topics: Antibodies; Carbon; Circular Dichroism; Cloning, Molecular; Folic Acid; gamma-Glutamyl Hydrolase; Humans; Hydrolysis; Immune System; Mass Spectrometry; Methotrexate; Neoplasms; Prodrugs; Pseudomonas; Recombinant Proteins; Stenotrophomonas; Zinc | 2018 |
Comparison of Serious Adverse Event Profiles Among Antirheumatic Agents Using Japanese Adverse Drug Event Report Database.
Topics: Adverse Drug Reaction Reporting Systems; Antirheumatic Agents; Bone Marrow Diseases; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Interleukin-6; Japan; Methotrexate; Neoplasms; Odds Ratio; Time Factors; Tuberculosis; Tumor Necrosis Factor-alpha | 2018 |
Zinc phthalocyanine-soybean phospholipid complex based drug carrier for switchable photoacoustic/fluorescence image, multiphase photothermal/photodynamic treatment and synergetic therapy.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Carriers; Glycine max; Humans; Hyperthermia, Induced; Indoles; Isoindoles; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Optical Imaging; Organometallic Compounds; Phospholipids; Photoacoustic Techniques; Photochemotherapy; Theranostic Nanomedicine; Zinc Compounds | 2018 |
Amphiphilic Y shaped miktoarm star copolymer for anticancer hydrophobic and hydrophilic drugs codelivery: Synthesis, characterization, in vitro, and in vivo biocompatibility study.
Topics: Antineoplastic Agents; Biocompatible Materials; Curcumin; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; HEK293 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Materials Testing; MCF-7 Cells; Methotrexate; Neoplasms; Polyesters; Polyethylene Glycols | 2018 |
Finding the ideal polyethylenimine-plasmid DNA system for co-delivery of payloads in cancer therapy.
Topics: Antineoplastic Agents; Biocompatible Materials; Cell Proliferation; Cell Survival; DNA; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Fibroblasts; HeLa Cells; Humans; Methotrexate; Neoplasms; Particle Size; Plasmids; Polyethyleneimine; Surface Properties | 2018 |
Histidine catabolism is a major determinant of methotrexate sensitivity.
Topics: Ammonia-Lyases; Animals; Cell Line, Tumor; CRISPR-Cas Systems; Female; Folic Acid Antagonists; Glutamate Formimidoyltransferase; Histidine; Humans; Male; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Multifunctional Enzymes; Neoplasms; Nucleotides; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Xenograft Model Antitumor Assays | 2018 |
Methotrexate-based amphiphilic prodrug nanoaggregates for co-administration of multiple therapeutics and synergistic cancer therapy.
Topics: A549 Cells; Animals; Antineoplastic Agents; Biological Availability; Camptothecin; Disulfides; Doxorubicin; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Liberation; Drug Synergism; Female; Folic Acid; Folic Acid Transporters; HeLa Cells; Humans; Hydrazones; Lysosomes; MCF-7 Cells; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Nanostructures; Neoplasm Transplantation; Neoplasms; Prodrugs | 2018 |
Histidine metabolism boosts cancer therapy.
Topics: Histidine; Humans; Methotrexate; Mutation; Neoplasms; Research | 2018 |
Improved microfluidic platform for simultaneous multiple drug screening towards personalized treatment.
Topics: Biosensing Techniques; Cell Line, Tumor; Cell Survival; Drug Evaluation, Preclinical; Humans; Methotrexate; Microfluidics; Nanoparticles; Neoplasms; Precision Medicine | 2019 |
Iron-gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Delayed-Action Preparations; Drug Liberation; Gold; Gold Alloys; Hep G2 Cells; Humans; Hyperthermia, Induced; Iron; Magnetic Fields; Metal Nanoparticles; Methotrexate; Mice; Neoplasms; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2018 |
Production of "biobetter" glucarpidase variants to improve drug detoxification and antibody directed enzyme prodrug therapy for cancer treatment.
Topics: Antibodies; Antimetabolites, Antineoplastic; Cell Proliferation; Cells, Cultured; Enzyme Therapy; gamma-Glutamyl Hydrolase; Humans; Hydrolysis; Leukocytes, Mononuclear; Methotrexate; Neoplasms; Polyethylene Glycols; Prodrugs; Recombinant Proteins; Serum Albumin, Human; T-Lymphocytes | 2019 |
Implementation and evaluation of high-dose methotrexate administration guidelines.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Middle Aged; Neoplasms; Palliative Care; Patient Discharge; Practice Guidelines as Topic; Prospective Studies; Retrospective Studies; Sodium Bicarbonate; Young Adult | 2019 |
Preparation and characterization of folic acid functionalized bioactive glass for targeted delivery and sustained release of methotrexate.
Topics: Antineoplastic Agents; Biocompatible Materials; Cell Survival; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Folic Acid; Glass; HeLa Cells; Humans; Methotrexate; Neoplasms | 2019 |
Label Free Ultrasmall Fluoromagnetic Ferrite-clusters for Targeted Cancer Imaging and Drug Delivery.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Ferric Compounds; Fluorescence; Folic Acid; Humans; Magnetic Phenomena; Magnetic Resonance Imaging; Male; Manganese Compounds; Methotrexate; Mice; Nanoparticles; Neoplasms; Serum Albumin, Bovine | 2019 |
Targeted Graphene Oxide Networks: Cytotoxicity and Synergy with Anticancer Agents.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Delivery Systems; Graphite; Humans; Methotrexate; Neoplasms | 2018 |
Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells.
Topics: Carbon; Cytosol; Formates; HCT116 Cells; HeLa Cells; Humans; MCF-7 Cells; Methotrexate; Mitochondria; Mitochondrial Proteins; Neoplasm Proteins; Neoplasms; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates | 2018 |
Poly-allylamine hydrochloride and fucoidan-based self-assembled polyelectrolyte complex nanoparticles for cancer therapeutics.
Topics: Antimetabolites, Antineoplastic; Biocompatible Materials; Delayed-Action Preparations; Drug Liberation; HeLa Cells; Humans; MCF-7 Cells; Methotrexate; Nanoparticles; Neoplasms; Polyamines; Polyelectrolytes; Polysaccharides | 2019 |
Novel biosurfactant and lipid core-shell type nanocapsular sustained release system for intravenous application of methotrexate.
Topics: Administration, Intravenous; Animals; Antineoplastic Agents; Cell Survival; Delayed-Action Preparations; Drug Liberation; Erythrocytes; Female; Hemolysis; Humans; Lipids; MCF-7 Cells; Methotrexate; Mice; Nanoparticles; Neoplasms; Rats, Sprague-Dawley; Surface-Active Agents; Tumor Burden; Valine | 2019 |
Controlled release of methotrexate from functionalized silica-gelatin aerogel microparticles applied against tumor cell growth.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Collagenases; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Gelatin; Gels; Humans; Methotrexate; Neoplasms; Silicon Dioxide | 2019 |
Combined antitumoral effects of pretubulysin and methotrexate.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; Female; Humans; Leukemia L1210; Methotrexate; Mice; Mice, Nude; Neoplasms; Oligopeptides; Uterine Cervical Neoplasms | 2019 |
Self-assembling water-soluble polymethacrylate-MTX conjugates: The significance of macromolecules architecture on drug conjugation efficiency, the final shape of particles, and drug release.
Topics: Cell Line, Transformed; Delayed-Action Preparations; Drug Carriers; Humans; Methotrexate; Neoplasms; Polymethacrylic Acids; Solubility; Water | 2019 |
[Chemotherapy-induced liver injury in children].
Topics: Adolescent; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Neoplasms | 2019 |
Halogenated derivatives of methotrexate as human dihydrofolate reductase inhibitors in cancer chemotherapy.
Topics: Folic Acid Antagonists; Halogens; Humans; Hydrogen Bonding; Methotrexate; Molecular Docking Simulation; Neoplasms; Protein Binding; Tetrahydrofolate Dehydrogenase; Thermodynamics | 2020 |
Production of "biobetter" variants of glucarpidase with enhanced enzyme activity.
Topics: Antimetabolites, Antineoplastic; Cloning, Molecular; Drug Design; Enzyme Stability; Enzyme Therapy; gamma-Glutamyl Hydrolase; Methotrexate; Models, Molecular; Neoplasms; Point Mutation; Prodrugs; Pseudomonas putida; Recombinant Proteins | 2019 |
PEGAylated graphene oxide/superparamagnetic nanocomposite as a high-efficiency loading nanocarrier for controlled delivery of methotrexate.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Drug Delivery Systems; Female; Graphite; HeLa Cells; Humans; Magnetite Nanoparticles; MCF-7 Cells; Methotrexate; Nanocomposites; Neoplasms; Polymers | 2019 |
Delivery of Oridonin and Methotrexate via PEGylated Graphene Oxide.
Topics: Biocompatible Materials; Cell Proliferation; Diterpenes, Kaurane; Drug Delivery Systems; Graphite; Hep G2 Cells; Humans; Methotrexate; Neoplasms; Polyethylene Glycols | 2019 |
Highly Water-Soluble Methotrexate-Polyethyleneglycol-Rhodamine Prodrug Micelle for High Tumor Inhibition Activity.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Delivery Systems; Female; Methotrexate; Mice; Mice, Nude; Micelles; Neoplasms; Polyethylene Glycols; Prodrugs; Rhodamines; Solubility; Water; Xenograft Model Antitumor Assays | 2019 |
Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy.
Topics: Cell Proliferation; Dithiothreitol; Endocytosis; Humans; K562 Cells; Mercaptopurine; Metal Nanoparticles; Methotrexate; Neoplasms; Porosity; Silicon Dioxide; Surface Properties | 2013 |
Enhanced antitumor efficacy by methotrexate conjugated Pluronic mixed micelles against KBv multidrug resistant cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Male; Methotrexate; Mice; Mice, Nude; Micelles; Neoplasms; Poloxamer; Rats; Rats, Sprague-Dawley; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Potential interactions with anticancer agents: a cross-sectional study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cisplatin; Cross-Sectional Studies; Diuretics; Drug Interactions; Female; Hospitals, Teaching; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Proton Pump Inhibitors | 2013 |
Cancer-free survival of psoriasis patients treated with methotrexate and cyclosporine combination.
Topics: Adult; Cyclosporine; Dermatologic Agents; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Surveys and Questionnaires; Turkey | 2014 |
Carrier-free functionalized multidrug nanorods for synergistic cancer therapy.
Topics: Animals; Camptothecin; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Carriers; Drug Synergism; Drug Therapy, Combination; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; KB Cells; MCF-7 Cells; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles; Nanotubes; Neoplasms; Paclitaxel | 2013 |
Reduction-degradable PEG-b-PAA-b-PEG triblock copolymer micelles incorporated with MTX for cancer chemotherapy.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dithiothreitol; Drug Carriers; Hep G2 Cells; Humans; KB Cells; Magnetic Resonance Spectroscopy; Methotrexate; Micelles; Neoplasms; Nylons; Oxidation-Reduction; Particle Size; Polyamines; Polyethylene Glycols; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared | 2013 |
Comparative cancer risk associated with methotrexate, other non-biologic and biologic disease-modifying anti-rheumatic drugs.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Risk; Sex Factors; Treatment Outcome | 2014 |
Investigation of effect of nutritional drink on chemotherapy-induced mucosal injury and tumor growth in an established animal model.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Beverages; Body Weight; Cell Proliferation; Diarrhea; Diet; Disease Models, Animal; Female; Goblet Cells; Methotrexate; Mucositis; Neoplasms; Nutritional Status; Random Allocation; Rats | 2013 |
Multicenter method evaluation of the ARK™ Methotrexate Immunoassay.
Topics: Antimetabolites, Antineoplastic; Calibration; Humans; Immunoassay; Methotrexate; Neoplasms; Reagent Kits, Diagnostic | 2014 |
Characterisation, cytotoxicity and apoptosis studies of methotrexate-loaded PLGA and PLGA-PEG nanoparticles.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Cell Line, Tumor; Cytotoxins; Drug Screening Assays, Antitumor; Humans; Lactic Acid; Methotrexate; Nanocapsules; Neoplasms; Particle Size; Polyethylene Glycols; Polyglactin 910; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2014 |
Polyacrylamide hybrid nanogels for targeted cancer chemotherapy via co-delivery of gold nanoparticles and MTX.
Topics: Acrylic Resins; Antimetabolites, Antineoplastic; Gels; Gold; Humans; Metal Nanoparticles; Methotrexate; Microscopy, Electron, Transmission; Neoplasms | 2013 |
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells.
Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Carrier Proteins; Cell Line, Tumor; Embryonic Stem Cells; Energy Metabolism; Fatty Acids; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Glycine; Humans; Male; Metabolic Flux Analysis; Metabolic Networks and Pathways; Methotrexate; Mice; Multienzyme Complexes; NADP; Neoplasms; Protein Biosynthesis; Purines; Serine; Transferases | 2013 |
Methotrexate-loaded PEGylated chitosan nanoparticles: synthesis, characterization, and in vitro and in vivo antitumoral activity.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Delivery Systems; HeLa Cells; Humans; Male; Methotrexate; Mice; Nanoparticles; Neoplasms; Particle Size; Polyethylene Glycols | 2014 |
Safety with ocrelizumab in rheumatoid arthritis: results from the ocrelizumab phase III program.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase III as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infections; Male; Meta-Analysis as Topic; Methotrexate; Middle Aged; Multicenter Studies as Topic; Neoplasms; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
The impact of 5-formyltetrahydrofolate on the anti-tumor activity of pralatrexate, as compared to methotrexate, in HeLa cells in vitro.
Topics: Aminopterin; Carbon-Nitrogen Ligases; Folic Acid Antagonists; HeLa Cells; Humans; Methotrexate; Neoplasms; Tumor Cells, Cultured | 2014 |
Risk of solid cancer in patients exposed to anti-tumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Cohort Studies; Colorectal Neoplasms; Etanercept; Female; Humans; Immunoglobulin G; Infliximab; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Receptors, Tumor Necrosis Factor; Registries; Risk Factors; Smoking; Tumor Necrosis Factor-alpha; United Kingdom | 2015 |
pH/redox responsive core cross-linked nanoparticles from thiolated carboxymethyl chitosan for in vitro release study of methotrexate.
Topics: Antimetabolites, Antineoplastic; Cell Survival; Chitosan; Delayed-Action Preparations; HeLa Cells; Humans; Hydrogen-Ion Concentration; Methotrexate; Nanoparticles; Neoplasms; Oxidation-Reduction; Sulfhydryl Compounds | 2014 |
Population-based cohort study on the risk of malignancy in East Asian children with juvenile idiopathic arthritis.
Topics: Adolescent; Arthritis, Juvenile; Asia, Eastern; Biological Products; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Neoplasms; Retrospective Studies; Risk Assessment; Risk Factors; Tumor Necrosis Factor-alpha | 2014 |
The risk of cancer in patients with rheumatoid arthritis taking tumor necrosis factor antagonists: a nationwide cohort study.
Topics: Adalimumab; Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cohort Studies; Cyclosporine; Etanercept; Female; Humans; Hydroxychloroquine; Immunoglobulin G; Incidence; Insurance; Male; Methotrexate; Middle Aged; Multivariate Analysis; Neoplasms; Outcome Assessment, Health Care; Proportional Hazards Models; Receptors, Tumor Necrosis Factor; Risk Factors; Taiwan; Tumor Necrosis Factor-alpha | 2014 |
Patients with rheumatoid arthritis have better functional and working ability but poorer general health and higher comorbidity rates today than in the late 1990s.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Cohort Studies; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Employment; Female; Finland; Health Status; Humans; Hydroxychloroquine; Hyperlipidemias; Hypertension; Male; Methotrexate; Middle Aged; Neoplasms; Patient Outcome Assessment; Respiratory Tract Diseases; Sulfasalazine; Tumor Necrosis Factor-alpha | 2015 |
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.
Topics: Animals; Cell Line, Tumor; Dendrimers; Female; Flow Cytometry; Lymph Nodes; Male; Methotrexate; Microscopy, Confocal; Neoplasms; Polyethylene Glycols; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 2015 |
I've been taking methotrexate for my rheumatoid arthritis (RA) for several years, but it doesn't seem to be helping my symptoms. My doctor suggested adding a biologic response modifier (BRM) drug, such as etanercept (Enbrel) or adalimumab (Humira) to my t
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Methotrexate; Neoplasms; Receptors, Tumor Necrosis Factor | 2014 |
Bacillus-shape design of polymer based drug delivery systems with janus-faced function for synergistic targeted drug delivery and more effective cancer therapy.
Topics: Animals; Antineoplastic Agents; Bacillus; Drug Carriers; Drug Delivery Systems; Flow Cytometry; HeLa Cells; Humans; Lactic Acid; Methotrexate; Mice; Nanoparticles; Neoplasms; Particle Size; Polyesters; Polyethylene Glycols; Polymers | 2015 |
Will nanobiosensors change therapeutic drug monitoring? The case of methotrexate.
Topics: Antimetabolites, Antineoplastic; Drug Monitoring; Humans; Methotrexate; Nanotechnology; Neoplasms; Surface Plasmon Resonance | 2015 |
[Folate antagonist].
Topics: Antimetabolites, Antineoplastic; Folic Acid Antagonists; Glutamates; Guanine; Humans; Methotrexate; Neoplasms; Pemetrexed | 2015 |
[Central nervous system neurotoxicity of anticancer chemotherapy].
Topics: Antineoplastic Agents; Central Nervous System; Humans; Leukoencephalopathy, Progressive Multifocal; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Posterior Leukoencephalopathy Syndrome | 2015 |
Long-term safety of etanercept and adalimumab compared to methotrexate in patients with juvenile idiopathic arthritis (JIA).
Topics: Adalimumab; Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Autoimmune Diseases; Biological Products; Child; Etanercept; Female; Germany; Humans; Inflammatory Bowel Diseases; Male; Methotrexate; Neoplasms; Opportunistic Infections; Prospective Studies; Registries; Tumor Necrosis Factor-alpha; Uveitis | 2016 |
In a methotrexate-induced model of intestinal mucositis, olmesartan reduced inflammation and induced enteropathy characterized by severe diarrhea, weight loss, and reduced sucrose activity.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Diarrhea; Disease Models, Animal; Imidazoles; Inflammation; Interleukin-1beta; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Mucositis; Neoplasms; Olmesartan Medoxomil; Rats, Wistar; Sucrose; Tetrazoles; Tumor Necrosis Factor-alpha; Weight Loss | 2015 |
Drug/Dye-Loaded, Multifunctional PEG-Chitosan-Iron Oxide Nanocomposites for Methotraxate Synergistically Self-Targeted Cancer Therapy and Dual Model Imaging.
Topics: Cell Line, Tumor; Cell Survival; Chitosan; Diagnostic Imaging; Drug Delivery Systems; Ferric Compounds; Humans; Methotrexate; Nanocomposites; Nanoparticles; Neoplasms; Polyethylene Glycols | 2015 |
Fabrication of biodendrimeric β-cyclodextrin via click reaction with potency of anticancer drug delivery agent.
Topics: Antineoplastic Agents; beta-Cyclodextrins; Cell Line, Tumor; Click Chemistry; Dendrimers; Drug Delivery Systems; Humans; Methotrexate; Neoplasms | 2015 |
[Focusing on the use of biologics in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Contraindications; Humans; Latent Tuberculosis; Methotrexate; Neoplasms; Tumor Necrosis Factor-alpha; Vaccination | 2015 |
Synthesis of the dendritic type β-cyclodextrin on primary face via click reaction applicable as drug nanocarrier.
Topics: Antimetabolites, Antineoplastic; beta-Cyclodextrins; Cell Line, Tumor; Click Chemistry; Delayed-Action Preparations; Dendrimers; Humans; Methotrexate; Neoplasms | 2015 |
A reversed-phase high performance liquid chromatography method for quantification of methotrexate in cancer patients serum.
Topics: Antimetabolites, Antineoplastic; Chromatography, Reverse-Phase; Humans; Limit of Detection; Methotrexate; Neoplasms; Reference Standards; Reproducibility of Results | 2015 |
Drug safety of systemic treatments for psoriasis: results from The German Psoriasis Registry PsoBest.
Topics: Adalimumab; Biological Products; Biological Therapy; Cardiovascular Diseases; Cyclosporine; Dermatologic Agents; Etanercept; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Registries; Ustekinumab | 2015 |
Salvage Treatment with Intracerebrospinal Fluid Thiotepa in Patients with Leptomeningeal Metastasis After Failure of Methotrexate-based Treatment.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Neoplasm Staging; Neoplasms; Prognosis; Retrospective Studies; Salvage Therapy; Survival Rate; Thiotepa | 2015 |
Graft-versus-host disease (GVHD) prophylaxis by using methotrexate decreases pre-engraftment syndrome and severe acute GVHD, and accelerates engraftment after cord blood transplantation.
Topics: Adolescent; Child; Child, Preschool; Cord Blood Stem Cell Transplantation; Cyclosporine; Disease-Free Survival; Female; Graft Survival; Graft vs Host Disease; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Incidence; Infant; Infant, Newborn; Male; Methotrexate; Neoplasms; Neutrophils; Retrospective Studies; Tacrolimus; Time Factors; Transplantation Conditioning; Treatment Outcome | 2016 |
For Patients With Cancer, Cure Is Not Enough.
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Cognition; Cognition Disorders; Female; Hospitalization; Humans; Male; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Osteosarcoma; Survivors | 2016 |
Histological Effect of Methotrexate and Folinic Acid on Oral Epithelium of Albino Rats.
Topics: Animals; Antidotes; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Epithelium; Leucovorin; Methotrexate; Mouth Mucosa; Neoplasms; Random Allocation; Rats; Stomatitis | 2016 |
Cancer in Elderly Onset Inflammatory Bowel Disease: A Population-Based Study.
Topics: Adrenal Cortex Hormones; Age of Onset; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Carcinoma; Colitis, Ulcerative; Colorectal Neoplasms; Crohn Disease; Female; Follow-Up Studies; France; Humans; Immunosuppressive Agents; Incidence; Inflammatory Bowel Diseases; Intestinal Neoplasms; Lymphoproliferative Disorders; Male; Mesalamine; Methotrexate; Middle Aged; Myeloproliferative Disorders; Neoplasms; Proportional Hazards Models; Protective Factors; Registries; Retrospective Studies; Risk Factors; Time Factors; Tumor Necrosis Factor-alpha | 2016 |
British Association of Dermatologists' guidelines for the safe and effective prescribing of methotrexate for skin disease 2016.
Topics: Adult; Alcohol Drinking; Biological Products; Bone Marrow Diseases; Checklist; Chemical and Drug Induced Liver Injury; Chickenpox; Child; Counseling; Cyclosporine; Dermatologic Agents; Drug Administration Routes; Drug Administration Schedule; Drug Approval; Drug Interactions; Drug Monitoring; Drug Overdose; Evidence-Based Medicine; Female; Hepatitis, Viral, Human; HIV Infections; Humans; Intraoperative Complications; Kidney Diseases; Lung Diseases; Methotrexate; Nausea; Neoplasms; Off-Label Use; Patient Education as Topic; Patient Safety; Pregnancy; Pregnancy Complications; Retinoids; Skin Diseases; Tuberculosis; Ultraviolet Rays; Vaccination | 2016 |
A novel dual-responsive core-crosslinked magnetic-gold nanogel for triggered drug release.
Topics: Drug Carriers; Female; Gels; Gold; Humans; Magnetite Nanoparticles; MCF-7 Cells; Methacrylates; Methotrexate; Neoplasms; Polyethylene Glycols | 2016 |
Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions.
Topics: Alleles; Bayes Theorem; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Methotrexate; Mutation; Neoplasms; Tetrahydrofolate Dehydrogenase | 2016 |
Low-dose methotrexate enhances cycling of highly anaplastic cancer cells.
Topics: Amino Acids; Animals; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Folic Acid; Male; Metabolic Networks and Pathways; Methotrexate; Neoplasms; Rats, Wistar | 2017 |
Increased Active Tumor Targeting by An αvβ3-Targeting and Cell-Penetrating Bifunctional Peptide-Mediated Dendrimer-Based Conjugate.
Topics: Animals; Cell Line, Tumor; Cell-Penetrating Peptides; Dendrimers; Drug Carriers; Drug Delivery Systems; Hep G2 Cells; Humans; MCF-7 Cells; Methotrexate; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Polyethylene Glycols | 2017 |
Use and effectiveness of tocilizumab among patients with rheumatoid arthritis: an observational study from the British Society for Rheumatology Biologics Register for rheumatoid arthritis.
Topics: Aged; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Pulmonary Fibrosis; Registries; Regression Analysis; Remission Induction; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; United Kingdom | 2017 |
Methotrexate and Cytarabine-Loaded Nanocarriers for Multidrug Cancer Therapy. Spectroscopic Study.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Antineoplastic Combined Chemotherapy Protocols; Calorimetry, Differential Scanning; Cytarabine; Drug Carriers; Methotrexate; Microscopy, Electron, Transmission; Nanoparticles; Neoplasms; Spectroscopy, Fourier Transform Infrared | 2016 |
Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert Meeting.
Topics: Adult; Age Factors; Chemical and Drug Induced Liver Injury; Child; Consensus; Denmark; Dermatology; Drug Dosage Calculations; Female; Humans; Immunosuppressive Agents; Liver Function Tests; Male; Methotrexate; Neoplasms; Patient Safety; Pregnancy; Pregnancy Complications; Psoriasis; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome | 2017 |
Psychosexual development and satisfaction in long-term survivors of childhood cancer: Neurotoxic treatment intensity as a risk indicator.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Case-Control Studies; Cranial Irradiation; Cytarabine; Female; Humans; Injections, Spinal; Leukemia; Lymphoma; Male; Methotrexate; Neoplasms; Neurotoxicity Syndromes; Orgasm; Personal Satisfaction; Psychosexual Development; Reproductive Health; Risk Factors; Sexual Partners; Surveys and Questionnaires; Survivors; Thiotepa; Young Adult | 2017 |
Long-term follow-up of renal function after high-dose methotrexate treatment in children.
Topics: Adolescent; Child; Child, Preschool; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Infant; Kidney; Male; Methotrexate; Neoplasms; Time Factors | 2008 |
[Outpatient chemotherapy and oncology network : Onco Pays-de-la-Loire experiment].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Deoxycytidine; Female; Fluorouracil; France; Gemcitabine; Home Care Services; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Trastuzumab | 2008 |
Long-term risk of malignancy among patients treated with immunosuppressive agents for ocular inflammation: a critical assessment of the evidence.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites; Azathioprine; Daclizumab; Databases, Factual; Humans; Immunoglobulin G; Immunosuppressive Agents; Inflammation; Longitudinal Studies; Methotrexate; Mycophenolic Acid; Neoplasms; Risk Factors; Tumor Necrosis Factor-alpha; Uveitis | 2008 |
Clinical and radiological features of brain neurotoxicity caused by antitumor and immunosuppressant treatments.
Topics: Adult; Aged; Antineoplastic Agents; Asparaginase; Brain; Cerebral Veins; Child; Cyclosporine; Diagnosis, Differential; Female; Graft Rejection; Humans; Immunosuppressive Agents; Liver Transplantation; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasms; Neurotoxicity Syndromes; Paraneoplastic Syndromes, Nervous System; Radiotherapy; Risk Factors; Venous Thrombosis | 2008 |
Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Line, Tumor; Cell Survival; Contrast Media; Drug Delivery Systems; Ferric Compounds; Humans; Image Enhancement; Magnetic Resonance Imaging; Methotrexate; Mice; Microscopy, Electron; Nanoparticles; Neoplasms; Scorpion Venoms; Spectroscopy, Fourier Transform Infrared; Xenograft Model Antitumor Assays | 2008 |
Surface-engineered dendrimers for dual drug delivery: a receptor up-regulation and enhanced cancer targeting strategy.
Topics: Antineoplastic Agents; Carrier Proteins; Dendrimers; Dose-Response Relationship, Drug; Drug Delivery Systems; Folate Receptors, GPI-Anchored; HeLa Cells; Humans; Methotrexate; Molecular Structure; Neoplasms; Receptors, Cell Surface; Tretinoin; Up-Regulation | 2008 |
Characterizing heterogeneous cellular responses to perturbations.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Artifacts; Biomarkers, Tumor; Dexamethasone; DNA Replication; Dose-Response Relationship, Drug; Doxorubicin; Genetic Heterogeneity; Glucocorticoids; HeLa Cells; Humans; Hydroxamic Acids; Methotrexate; Microscopy, Fluorescence; Models, Biological; Neoplasms; Paclitaxel; Phenotype; Protein Synthesis Inhibitors; Tubulin Modulators | 2008 |
Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Drug Interactions; Female; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Neoplasms; Proton Pump Inhibitors; Young Adult | 2009 |
Population pharmacokinetics of high-dose methotrexate in Japanese adult patients with malignancies: a concurrent analysis of the serum and urine concentration data.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Bayes Theorem; Creatinine; Dose-Response Relationship, Drug; Drug Monitoring; Female; Forecasting; Humans; Japan; Male; Methotrexate; Middle Aged; Models, Biological; Neoplasms; Nonlinear Dynamics; Retrospective Studies; Software; Tissue Distribution; Young Adult | 2008 |
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
Topics: Aminopterin; Cell Line, Tumor; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Kinetics; Methotrexate; Neoplasms; Pemetrexed; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Xenograft Model Antitumor Assays | 2009 |
Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Indoles; Inhibitory Concentration 50; Methotrexate; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; RNA, Messenger; Sunitinib; Time Factors; Topotecan; Transfection; Up-Regulation; Vincristine | 2009 |
Antitumor therapy based on cellular competition.
Topics: Animals; Antineoplastic Agents; Bystander Effect; Drug Resistance, Neoplasm; Ganciclovir; Green Fluorescent Proteins; HCT116 Cells; Humans; Luminescent Proteins; Methotrexate; Mice; Mice, Inbred BALB C; Neoplasms; Red Fluorescent Protein; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Transfection; Xenograft Model Antitumor Assays | 2009 |
In search of the magic bullet.
Topics: Antimetabolites, Antineoplastic; Drug Combinations; Humans; Insulin-Like Growth Factor I; Methotrexate; Neoplasms | 2009 |
Pivotal role of dihydrofolate reductase knockdown in the anticancer activity of 2-hydroxyoleic acid.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Membrane; Fatty Acids; Folic Acid Antagonists; Humans; Jurkat Cells; Leucovorin; Lipids; Methotrexate; Neoplasms; Oleic Acids; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 2009 |
Variations in the content of CD34+ cells in the peripheral blood of cancer patients receiving out-patient chemotherapy.
Topics: Adolescent; Adult; Aged; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Leukocyte Count; Leukocytes; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms; Outpatients; Prostatic Neoplasms; Young Adult | 1999 |
The effects of drug transporter inhibitors on the pharmacokinetics and tissue distribution of methotrexate in normal and tumor-bearing mice: a microdialysis study.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cyclosporine; Drug Delivery Systems; Drug Interactions; Female; Humans; Methotrexate; Mice; Mice, Nude; Microdialysis; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Neoplasms; Probenecid; Tissue Distribution; Xenograft Model Antitumor Assays | 2010 |
Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies: does the risk change with the time since start of treatment?
Topics: Adalimumab; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Dose-Response Relationship, Drug; Etanercept; Female; Humans; Immunoglobulin G; Incidence; Infliximab; Male; Methotrexate; Middle Aged; Neoplasms; Receptors, Tumor Necrosis Factor; Registries; Retrospective Studies; Risk Factors; Sweden; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
Converting cancer mutations into therapeutic opportunities.
Topics: Antimetabolites, Antineoplastic; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Mutation; MutS Homolog 2 Protein; Neoplasms; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; PTEN Phosphohydrolase | 2009 |
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2.
Topics: Antimetabolites, Antineoplastic; Antioxidants; Base Sequence; Cell Line, Tumor; DNA Damage; DNA Mismatch Repair; Folic Acid; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Molecular Sequence Data; MutS Homolog 2 Protein; Neoplasms; Oxidation-Reduction; RNA, Antisense | 2009 |
Pharmacokinetics of methotrexate in solid tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Carcinoma 256, Walker; Female; Infusions, Intravenous; Liver Neoplasms, Experimental; Mammary Neoplasms, Animal; Methotrexate; Neoplasm Transplantation; Neoplasms; Rats; Rats, Inbred BUF; Rats, Sprague-Dawley | 1979 |
Statistical examination to determine whether only 48-h value for serum concentration during high-dose methotrexate therapy is a predictor for clinical adverse events using ordered logistic regression analysis.
Topics: Adult; Aged; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Predictive Value of Tests; Regression Analysis; Retrospective Studies; Risk Factors | 2010 |
Therapeutic drug monitoring of methotrexate in cerebrospinal fluid after systemic high-dose infusion in children: can the burden of intrathecal methotrexate be reduced?
Topics: Adolescent; Aging; Antimetabolites, Antineoplastic; Biotransformation; Child; Child, Preschool; Drug Monitoring; Humans; Infant; Infusions, Intravenous; Injections, Spinal; Leukemia; Mass Spectrometry; Methotrexate; Neoplasms; Retrospective Studies; Risk Assessment; Young Adult | 2010 |
A breast cancer prognostic signature predicts clinical outcomes in multiple tumor types.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Pharmacological; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Carcinoma, Non-Small-Cell Lung; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Gene Expression Profiling; Humans; Lung Neoplasms; Methotrexate; Neoplasms; Prognosis; Survival Analysis; Tamoxifen; Treatment Outcome | 2010 |
Population pharmacokinetics of methotrexate in Indian cancer patients.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Female; Humans; India; Male; Methotrexate; Middle Aged; Neoplasms; Prognosis; Tissue Distribution | 2010 |
Delayed elimination of methotrexate associated with co-administration of proton pump inhibitors.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Drug Interactions; Humans; Methotrexate; Middle Aged; Neoplasms; Proton Pump Inhibitors; Retrospective Studies; Young Adult | 2010 |
Pediatric rheumatology: JIA, treatment and possible risk of malignancies.
Topics: Adalimumab; Adolescent; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arthritis, Juvenile; Child; Child, Preschool; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immunosuppressive Agents; Infliximab; Lymphoma; Methotrexate; Neoplasms; Receptors, Tumor Necrosis Factor; Risk Factors; Tumor Necrosis Factor-alpha | 2011 |
Report on malignancies in the German juvenile idiopathic arthritis registry.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Female; Germany; Humans; Infant; Lymphoma; Male; Methotrexate; Neoplasms; Registries; Risk Factors; Tumor Necrosis Factor-alpha | 2011 |
Evaluating performance of a decision support system to improve methotrexate pharmacotherapy in children and young adults with cancer.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bayes Theorem; Child; Child, Preschool; Decision Support Systems, Clinical; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Infant; Leucovorin; Male; Methotrexate; Neoplasms; Software; Standard of Care; Young Adult | 2011 |
APEX microarray panel for genotyping polymorphisms in cancer chemotherapy and estimation frequencies in a Slovak population.
Topics: Antineoplastic Agents; Biomarkers, Pharmacological; Camptothecin; Drug Resistance, Neoplasm; Fluorouracil; Gene Frequency; Genetic Association Studies; Humans; Irinotecan; Linkage Disequilibrium; Methotrexate; Neoplasms; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Slovakia | 2011 |
Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation.
Topics: Antimetabolites; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; HeLa Cells; Histone Deacetylases; Humans; Hydroxamic Acids; Male; Methotrexate; Molecular Targeted Therapy; Neoplasms; Repressor Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2011 |
Herpes simplex encephalitis in patients with cancer.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cranial Irradiation; Dexamethasone; DNA, Viral; Encephalitis, Herpes Simplex; Female; Humans; Incidence; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasms; New York; Polymerase Chain Reaction; Procarbazine; Prognosis; Retrospective Studies; Rituximab; Simplexvirus; Tomography, X-Ray Computed; Vincristine | 2011 |
Novel integrin-targeted binding-triggered drug delivery system for methotrexate.
Topics: Amino Acid Sequence; Antimetabolites, Antineoplastic; Drug Delivery Systems; Human Umbilical Vein Endothelial Cells; Humans; Integrin alphaVbeta3; Methotrexate; Models, Molecular; Neoplasms; Oligopeptides; Prodrugs; Protein Binding; Protein Conformation | 2011 |
Preclinical evaluation of pemetrexed in pediatric solid tumors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Gene Expression; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Methotrexate; Neoplasms; Pediatrics; Pemetrexed; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
The role of osteocyte apoptosis in cancer chemotherapy-induced bone loss.
Topics: Acid Phosphatase; Animals; Antimetabolites, Antineoplastic; Apoptosis; Bone Resorption; Caspase 3; Cell Differentiation; Culture Media, Conditioned; Extracellular Matrix Proteins; Homeostasis; Interleukin-11; Interleukin-6; Isoenzymes; Male; Methotrexate; Neoplasms; Osteoclasts; Osteocytes; Osteogenesis; Phosphoproteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tartrate-Resistant Acid Phosphatase | 2012 |
Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate.
Topics: Apoptosis; Cell Line, Tumor; Dendrimers; Folic Acid Antagonists; Humans; Methotrexate; Nanoconjugates; Neoplasms; Photolysis; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays | 2012 |
Methotrexate-mediated inhibition of RAD51 expression and homologous recombination in cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; DNA End-Joining Repair; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, BRCA2; Homologous Recombination; Humans; Methotrexate; Neoplasms; Rad51 Recombinase; Rad52 DNA Repair and Recombination Protein; Recombinational DNA Repair; RNA, Small Interfering | 2012 |
Tumor necrosis factor inhibitors and cancer in juvenile idiopathic arthritis: disentangling the web.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Female; Humans; Male; Methotrexate; Neoplasms; Tumor Necrosis Factor-alpha | 2012 |
Rates of malignancy associated with juvenile idiopathic arthritis and its treatment.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Child; Female; Humans; Incidence; Male; Methotrexate; Neoplasms; Prevalence; Tumor Necrosis Factor-alpha | 2012 |
Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster.
Topics: Animals; Carboplatin; Deoxycytidine; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Fertility; Floxuridine; Gemcitabine; High-Throughput Screening Assays; Humans; Methotrexate; Mitomycin; Models, Animal; Neoplasms; Topotecan | 2012 |
Low prevalence of high-dose methotrexate nephropathy in patients with malignancy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Child; Child, Preschool; Creatinine; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Male; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Young Adult | 2012 |
Metronomic chemotherapy with cyclophosphamide and dexamethasone in patients with metastatic carcinoma of the prostate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Humans; Male; Methotrexate; Neoplasms; Pyrazoles; Sulfonamides | 2012 |
The in vivo antitumor activity of LHRH targeted methotrexate-human serum albumin nanoparticles in 4T1 tumor-bearing Balb/c mice.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Female; Gonadotropin-Releasing Hormone; Methotrexate; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasm Transplantation; Neoplasms; Serum Albumin; Tumor Burden | 2012 |
Bright blue emitting CuSe/ZnS/silica core/shell/shell quantum dots and their biocompatibility.
Topics: Biocompatible Materials; Cell Aggregation; Cell Death; Complement Activation; Drug Delivery Systems; Hemolysis; Hep G2 Cells; Humans; Light; Methotrexate; Microscopy, Fluorescence; Nanoparticles; Neoplasms; Platelet Factor 4; Quantum Dots; Selenium Compounds; Silicon Dioxide; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Sulfides; Zinc Compounds | 2012 |
Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic.
Topics: Biological Availability; Cell Line, Tumor; Dendrimers; Esterases; Folate Receptors, GPI-Anchored; Folic Acid; Humans; KB Cells; Methotrexate; Molecular Targeted Therapy; Neoplasms; Tetrahydrofolate Dehydrogenase | 2012 |
Monitoring methotrexate in clinical samples from cancer patients during chemotherapy with a LSPR-based competitive sensor.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence Polarization Immunoassay; Folic Acid; Gold; Humans; Metal Nanoparticles; Methotrexate; Neoplasms; Solid Phase Extraction; Surface Plasmon Resonance; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase | 2012 |
Methotrexate-conjugated and hyperbranched polyglycerol-grafted Fe₃O₄ magnetic nanoparticles for targeted anticancer effects.
Topics: 3T3 Cells; Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Line, Tumor; Cell Survival; Drug Carriers; Endocytosis; Glycerol; Humans; Magnetite Nanoparticles; Methotrexate; Mice; Neoplasms; Polymers | 2013 |
Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.
Topics: Biological Transport; Folic Acid; Folic Acid Antagonists; Glycine; Humans; Methotrexate; Mitochondria; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serine; Transcriptome | 2013 |
Delivery of chemotherapeutic drugs in tumour cell-derived microparticles.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Membrane; Cell-Derived Microparticles; Cisplatin; Drug Carriers; Female; Liver Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Mice, SCID; Neoplasms; Neoplasms, Experimental; Ovarian Neoplasms | 2012 |
Preparation and characterization of methotrexate-loaded microcapsules.
Topics: Alginates; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Delayed-Action Preparations; Drug Compounding; Glucuronic Acid; Hexuronic Acids; Humans; Hyaluronic Acid; Methotrexate; Neoplasms; Rats | 2014 |
Progression elevated gene-3, PEG-3, induces genomic instability in rodent and human tumor cells.
Topics: Animals; Antigens, Differentiation; Antimetabolites, Antineoplastic; Carcinoma; Cell Cycle Proteins; Cell Division; Cells, Cultured; Chromosome Aberrations; Drug Resistance, Neoplasm; Embryo, Mammalian; Female; Fibroblasts; Gene Amplification; Genome; Humans; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms; Prostatic Neoplasms; Protein Phosphatase 1; Proto-Oncogene Proteins; Rats; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Uterine Cervical Neoplasms | 2002 |
Monitoring of methotrexate and reduced folates in the cerebrospinal fluid of cancer patients.
Topics: Chromatography, High Pressure Liquid; Drug Monitoring; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Neoplasms; Tetrahydrofolates | 2002 |
Carboxypeptidase-G2 rescue in cancer patients with delayed methotrexate elimination after high-dose methotrexate therapy.
Topics: Adult; Antidotes; Female; gamma-Glutamyl Hydrolase; Humans; Kidney Diseases; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma; Treatment Outcome | 2002 |
In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Humans; In Vitro Techniques; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms; Serum Albumin; Thymidylate Synthase; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
Decreased transfusion requirements in patients given stem cell allografts using a non-myeloablative conditioning regimen: a single institution experience.
Topics: Adolescent; Adult; Busulfan; Child; Child, Preschool; Cyclophosphamide; Cyclosporine; Erythrocyte Transfusion; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Hematologic Neoplasms; Hematopoietic Stem Cell Mobilization; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Peripheral Blood Stem Cell Transplantation; Platelet Transfusion; Prospective Studies; Recombinant Proteins; Transplantation Conditioning; Transplantation, Homologous; Vidarabine | 2003 |
Shaping of tumor and drug-resistant genomes by instability and selection.
Topics: Base Pair Mismatch; Cell Line; DNA Repair; Drug Resistance, Neoplasm; Gene Dosage; Genome; Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 2003 |
Rare expression of epithelial cell adhesion molecule on residual micrometastatic breast cancer cells after adjuvant chemotherapy.
Topics: Adult; Aged; Anthracyclines; Antigens, Neoplasm; Bone Marrow Cells; Breast Neoplasms; Cell Adhesion; Cell Adhesion Molecules; Cell Line, Tumor; Centrifugation, Density Gradient; Chemotherapy, Adjuvant; Cohort Studies; Cyclophosphamide; Epithelial Cell Adhesion Molecule; Epitopes; Female; Fluorouracil; Humans; Immunohistochemistry; Immunotherapy; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms; Prognosis | 2003 |
Observations on the effects of the folic acid antagonists, aminopterin and amethopterin, in patients with advanced neoplasms.
Topics: Aminopterin; Folic Acid Antagonists; Methotrexate; Neoplasms | 1952 |
Amethopterin: a toxic tumour growth inhibitor.
Topics: Folic Acid Antagonists; Growth Inhibitors; Humans; Methotrexate; Neoplasms | 1952 |
The influence of amethopterin on the survival time of leukemic mice with respect to food intake, body weight changes, and tumor growth.
Topics: Animals; Body Weight; Eating; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Nutritional Sciences | 1958 |
Intra-arterial infusions of pelvic tumors with amethopterin.
Topics: Folic Acid Antagonists; Genitalia; Genitalia, Female; Infusions, Intra-Arterial; Methotrexate; Neoplasms; Pelvic Neoplasms; Perfusion | 1961 |
Tumor and marrow damage occurring from methotrexate, monofluoromethotrexate, difluoromethotrexate, and dichloromethotrexate.
Topics: Animals; Bone Marrow; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Neoplasms, Experimental; Vegetables | 1961 |
Remissions produced with the use of Methotrexate in patients with mycosis fungoides.
Topics: Folic Acid Antagonists; Methotrexate; Mycosis Fungoides; Neoplasms | 1960 |
Methotrexate in treatment of metastasizing chorioncarcinoma: a case report.
Topics: Choriocarcinoma; Folic Acid Antagonists; Methotrexate; Neoplasms | 1959 |
Studies on the folic acid vitamins. VII. The effects of large doses of amethopterin in patients with cancer.
Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Folic Acid; Folic Acid Antagonists; Methotrexate; Neomycin; Neoplasms; Vitamins | 1962 |
Report of a case of choriocarcinoma treated with methotrexate.
Topics: Choriocarcinoma; Female; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Uterine Neoplasms | 1962 |
Cancer therapy by intra-arterial methotrexate infusion. Protection of mucous membranes by topically applied citrovorum factor with hyaluronidase.
Topics: Folic Acid; Folic Acid Antagonists; Hyaluronoglucosaminidase; Infusions, Intra-Arterial; Leucovorin; Methotrexate; Mouth; Mucous Membrane; Neoplasms; Pharynx | 1962 |
Intraarterial chemotherapy and x-ray therapy in cancer of the head and neck. Technique, methods, results and complications.
Topics: Head; Head and Neck Neoplasms; Humans; Mechlorethamine; Methotrexate; Neck; Neoplasms; Thiotepa; X-Ray Therapy | 1963 |
Chemotherapy of malignant disease. II. Diseases of lymphoid tissue and bone marrow.
Topics: Adrenal Cortex Hormones; Aged; Bone Marrow; Busulfan; Chlorambucil; Cyclophosphamide; Hodgkin Disease; Humans; Leukemia; Lymphoid Tissue; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Multiple Myeloma; Neoplasms; Sarcoma | 1962 |
Methotrexate in inoperable cancer.
Topics: Humans; Methotrexate; Neoplasms | 1963 |
Influences of anticancer agents on the activities of liver catalase, uricase, and xanthine oxidase in normal and tumor-bearing mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Azaguanine; Carboxylic Acids; Carcinoma, Ehrlich Tumor; Catalase; Cyclopentanes; Liver; Mercaptopurine; Methotrexate; Mice; N-Glycosyl Hydrolases; Neoplasms; Oxidoreductases; Thiotepa; Urate Oxidase; Xanthine Oxidase | 1963 |
[On the possibility of autologous bone marrow cell transfusion].
Topics: Anemia; Anemia, Aplastic; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cobalt Isotopes; Humans; Methotrexate; Neoplasms | 1963 |
A symposium on cancer chemotherapy. I. Hormone-producing tumors.
Topics: Adrenal Cortex Neoplasms; Choriocarcinoma; Female; Humans; Methotrexate; Neoplasms; Pregnancy; Trophoblastic Neoplasms | 1962 |
The biology of lymphocytic choriomeningitis infection: virus-induced immune disease.
Topics: Autoimmune Diseases; Biology; Chlorambucil; Endotoxins; Immune System Diseases; Lymphocytic Choriomeningitis; Methotrexate; Neoplasms; Neoplasms, Experimental; Radiation Effects | 1962 |
[Atypical Guerin T8 epithelioma in the white rat].
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Carcinoma; Immunity; Lymphatic Metastasis; Methotrexate; Neoplasms; Neoplasms, Experimental; Radiation Effects; Rats | 1963 |
Cancer chemotherapy by arterial infusion.
Topics: Antineoplastic Agents; Fluorouracil; Humans; Injections; Injections, Intramuscular; Leucovorin; Methotrexate; Neoplasms | 1963 |
The chemotherapy of intrathoracic tumors.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Dactinomycin; Humans; Mechlorethamine; Methotrexate; Neoplasms; Prednisone; Progesterone; Testosterone; Thiotepa; Thoracic Neoplasms; Vinblastine | 1962 |
Approaches for combined radiation and chemotherapy.
Topics: Antineoplastic Agents; DNA; DNA, Bacterial; DNA, Neoplasm; Floxuridine; Humans; Methotrexate; Neoplasms; Radiotherapy | 1963 |
Chemotherapy of malignant disease. I. Solid tumours.
Topics: Cyclophosphamide; Dactinomycin; Fluorouracil; Mechlorethamine; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Thiotepa | 1962 |
Cancer chemotherapy by intra-arterial infusion.
Topics: Dactinomycin; Fluorouracil; Humans; Infusions, Intra-Arterial; Mechlorethamine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Thiotepa | 1963 |
Biochemical studies of the division cycle of mammalian cells: evidence for the premitotic period.
Topics: Animals; Cell Division; DNA; DNA, Neoplasm; Glycine; Humans; Mast Cells; Methotrexate; Neoplasms; Neoplasms, Experimental; Thymidine; Xanthines | 1963 |
[On the subject of medical therapy of tumors in gynecology. II].
Topics: Choriocarcinoma; Female; Genital Neoplasms, Female; Gynecology; Humans; Methotrexate; Neoplasms | 1963 |
[On the subject of medical therapy of tumors in gynecology].
Topics: Choriocarcinoma; Female; Genital Neoplasms, Female; Gynecology; Humans; Methotrexate; Neoplasms | 1963 |
[Trials of chemotherapy of solid tumors with an antimetabolite (4-amino-10-methylpteroilglutamic acid)].
Topics: Antimetabolites; Humans; Methotrexate; Neoplasms | 1962 |
Chemotherapy for tumors of the head and neck.
Topics: Head; Head and Neck Neoplasms; Humans; Leucovorin; Methotrexate; Mouth Neoplasms; Neoplasms | 1962 |
The use of methotrexate orally in treatment of squamous cancers of the head and neck.
Topics: Carcinoma, Squamous Cell; Folic Acid Antagonists; Head; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Neoplasms | 1962 |
A METHOD OF CONTINUOUS INTRAVASCULAR INFUSION OF METHOTREXATE IN THE PALLIATIVE TREATMENT OF MALIGNANT DISEASE IN PATIENTS.
Topics: Brain Neoplasms; Chemotherapy, Cancer, Regional Perfusion; Head and Neck Neoplasms; Humans; Leucovorin; Lung Neoplasms; Melanoma; Methotrexate; Neoplasms; Palliative Care; Pelvic Neoplasms | 1963 |
COMBINED IRRADIATION AND CHEMOTHERAPY IN THE TREATMENT OF SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK.
Topics: Carcinoma; Carcinoma, Squamous Cell; Head; Head and Neck Neoplasms; Humans; Methotrexate; Neoplasms; Squamous Cell Carcinoma of Head and Neck | 1963 |
STUDIES ON IMMUNITY TO LEUKEMIA L1210 IN MICE.
Topics: Animals; Immunity; Leukemia L1210; Methotrexate; Mice; Neoplasms; Research; Skin Transplantation; Spleen; Tissue Extracts | 1963 |
LEUKEMIA. AN ANALYSIS OF 209 CASES FROM THE ELLIS FISCHEL STATE CANCER HOSPITAL.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Busulfan; Cancer Care Facilities; Child; Chlorambucil; Cobalt Isotopes; Leukemia; Leukemia, Lymphoid; Mechlorethamine; Methotrexate; Neoplasms | 1963 |
TROPHOBLASTIC TUMOURS. CHEMOTHERAPY AND DEVELOPMENTS.
Topics: Antineoplastic Agents; Brain Neoplasms; Castration; Choriocarcinoma; Female; Humans; Hydatidiform Mole, Invasive; Hysterectomy; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasms; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms | 1963 |
LOW-FLOW FAIL-SAFE INTRA-ARTERIAL INFUSION.
Topics: Arteries; Catheterization; Equipment and Supplies; Head; Head and Neck Neoplasms; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Methotrexate; Neoplasms | 1963 |
CONTINUOUS INFUSION OF ADVANCED PELVIC MALIGNANCIES BY RETROGRADE FEMORAL CATHETER.
Topics: Catheters; Fluorouracil; Infusions, Parenteral; Leucovorin; Methotrexate; Neoplasms; Pelvic Neoplasms; Pelvis | 1963 |
OSTEOGENIC SARCOMA IN CHILDHOOD.
Topics: Adolescent; Bone Neoplasms; Child; Humans; Infant; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Osteosarcoma; Radiography; Sarcoma; Surgical Procedures, Operative | 1963 |
SUMMARY OF INFORMAL DISCUSSIONS ON THE ROLE OF FOLIC ACID ANTAGONISTS.
Topics: Enzyme Inhibitors; Folic Acid Antagonists; Methotrexate; Neoplasms; Oxidoreductases; Pharmacology | 1963 |
THE TREATMENT OF HEAD AND NECK CANCER BY REGIONAL CHEMOTHERAPY.
Topics: Chemotherapy, Cancer, Regional Perfusion; Head; Head and Neck Neoplasms; Humans; Methotrexate; Neoplasms | 1963 |
[SENSITIVITY OF THE GUERIN EPITHELIOMA T8 IN THE WISTAR RAT TO AMETHOPTERIN].
Topics: Animals; Carcinoma; Methotrexate; Neoplasm Regression, Spontaneous; Neoplasms; Neoplasms, Glandular and Epithelial; Rats; Rats, Wistar; Research | 1963 |
[APROPOS OF THE TREATMENT OF TUMORS OF THE TESTICLE].
Topics: Castration; Choriocarcinoma; Dactinomycin; Female; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Mechlorethamine; Methotrexate; Neoplasms; Pregnancy; Teratoma; Testicular Neoplasms | 1963 |
[REPORT ON REGIONAL CHEMOTHERAPY IN CANCEROLOGY].
Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Mannomustine; Methotrexate; Neoplasms; Toxicology | 1963 |
THE TREATMENT OF LEUKEMIA.
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Prognosis; Triamcinolone | 1964 |
[PROLONGED INTRA-ARTERIAL CHEMOTHERAPY USING AN ANTINEOPLASTIC INFUSION IN THE TREATMENT OF INOPERABLE NEOPLASIA. 1. INTRODUCTION, MATERIAL AND METHOD].
Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Infusions, Parenteral; Mechlorethamine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Toxicology | 1963 |
[ON THE COMBINED SURGICAL AND DRUG THERAPY OF CHORIOCARCINOMA IN WOMEN].
Topics: Choriocarcinoma; Fallopian Tube Neoplasms; Female; Humans; Methotrexate; Neoplasm Metastasis; Neoplasms; Pregnancy; Pregnancy, Tubal; Surgical Procedures, Operative; Urinary Bladder Neoplasms | 1963 |
[PULMONARY METASTASES OF CHORIOCARCINOMA TREATED WITH METHOTREXATE AND RADIOTHERAPY].
Topics: Aged; Choriocarcinoma; Female; Humans; Lung Neoplasms; Methotrexate; Neoplasms; Pregnancy | 1963 |
MULTIPLE KERATOACANTHOMAS. A CASE STUDY OF THE ERUPTIVE TYPE WITH OBSERVATIONS ON PATHOGENESIS.
Topics: Aminopterin; Black People; Carcinoma; Carcinoma, Squamous Cell; Diagnosis, Differential; Foot Diseases; Hand Dermatoses; Histocytochemistry; Humans; Keratoacanthoma; Laryngeal Neoplasms; Methotrexate; Neoplasms; Pathology; Ultraviolet Rays | 1964 |
CHROMOSOME STUDIES IN LEUKEMIA. I. EVIDENCE FOR THE ORIGIN OF LEUKEMIC STEM LINES FROM ANEUPLOID MUTANTS.
Topics: Aneuploidy; Bone Marrow Examination; Child; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Microscopy, Electron, Scanning Transmission; Neoplasms; Pathology; Prednisone | 1964 |
CENTRAL NERVOUS SYSTEM COMPLICATIONS OF CHILDREN WITH ACUTE LEUKEMIA. AN EVALUATION OF TREATMENT METHODS.
Topics: Brain Diseases; Central Nervous System Diseases; Child; Humans; Leukemia; Meninges; Methotrexate; Neoplasms; Neurologic Manifestations; Prognosis; Spinal Cord; Spinal Puncture | 1964 |
DRUGS OF CURRENT USE FOR THE TREATMENT OF CANCER AND ALLIED DISEASES.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; Aziridines; Busulfan; Colchicine; Dactinomycin; Diethylstilbestrol; Estrogens; Fluorouracil; Gonadal Steroid Hormones; Mercaptopurine; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Podophyllum; Progestins; Quinones; Thiotepa; Triethylenemelamine; Urethane; Vinblastine | 1963 |
[REMARKS ON THE USE OF AMETHOPTERIN IN THE TREATMENT OF SOLID TUMORS].
Topics: Humans; Methotrexate; Neoplasms | 1963 |
CANCER CHEMOTHERAPY BY PROLONGED ARTERIAL INFUSION.
Topics: Angiography; Arm; Brachiocephalic Trunk; Brain Neoplasms; Carotid Arteries; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorescent Dyes; Fluorouracil; Head and Neck Neoplasms; Hepatic Artery; Humans; Iliac Artery; Leg; Liver Neoplasms; Methotrexate; Neoplasms; Pelvic Neoplasms; Subclavian Artery; Temporal Arteries; Thoracic Neoplasms; Toxicology | 1964 |
THE TREATMENT OF MALIGNANT DISEASE BY REGIONAL CHEMOTHERAPY.
Topics: Antimetabolites; Antineoplastic Agents; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Geriatrics; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Melanoma; Melphalan; Methotrexate; Mouth Neoplasms; Neoplasms; Neoplasms, Muscle Tissue; Nitrogen Mustard Compounds; Sarcoma; Toxicology; Triethylenemelamine | 1963 |
DETERMINATIONS OF THE LEVELS OF SERUM FOLATE IN PATIENTS WITH CARCINOMA OF THE HEAD AND NECK TREATED WITH METHOTREXATE.
Topics: Blood Chemical Analysis; Carcinoma, Squamous Cell; Folic Acid; Humans; Methotrexate; Nasopharyngeal Neoplasms; Neoplasms; Nose Neoplasms; Osteosarcoma; Pathology; Pharmacology; Pharyngeal Neoplasms; Sarcoma; Tongue Neoplasms | 1964 |
REGIONAL CHEMOTHERAPY IN MALIGNANT DISEASE: A REVIEW OF FIFTEEN CASES.
Topics: Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Female; Hormones; Humans; Injections, Intra-Arterial; Melanoma; Methotrexate; Neoplasms; Ovarian Neoplasms; Palatal Neoplasms; Pharyngeal Neoplasms; Tongue Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms | 1963 |
INTRA-ARTERIAL INFUSION FOR HEAD AND NECK CANCER.
Topics: Antineoplastic Agents; Brain Neoplasms; Dactinomycin; Facial Neoplasms; Fluorouracil; Head and Neck Neoplasms; Humans; Hydrogen Peroxide; Infusions, Intra-Arterial; Infusions, Parenteral; Injections, Intra-Arterial; Methotrexate; Mouth Neoplasms; Neoplasms; Nitrogen Mustard Compounds | 1964 |
CHEMOTHERAPY FOR CANCER.
Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Dactinomycin; Exudates and Transudates; Fluorouracil; Humans; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Pericardium; Peritoneal Cavity; Pleural Effusion; Surgical Procedures, Operative; Vinblastine | 1964 |
THE RETICULOSES.
Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Genetic Diseases, X-Linked; Geriatrics; Hodgkin Disease; Leukemia; Leukemia, Hairy Cell; Leukemia, Lymphoid; Lymphatic Diseases; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Mycosis Fungoides; Neoplasms; Pathology; Peptide Nucleic Acids; Physiology; Sarcoma; Severe Combined Immunodeficiency | 1964 |
TREATMENT OF SIX CASES OF CHORIONEPITHELIOMA (CHORIOCARCINOMA) WITH AMETHOPTERIN.
Topics: Brain Neoplasms; Choriocarcinoma; Female; Gonadotropins; Humans; Leukocyte Count; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Neoplasms; Pregnancy | 1963 |
CLINICOPATHOLOGIC CONFERENCE.
Topics: Black People; Bromides; Diagnosis, Differential; Drug Eruptions; Fluorouracil; Granuloma; Humans; Keratoacanthoma; Methotrexate; Neoplasm Metastasis; Neoplasms; Pathology | 1964 |
BASIC ETIOLOGIC CONCEPTS OF HYDATIFORM MOLE AND CHORIOEPITHELIOMA.
Topics: Animals; Choriocarcinoma; Female; Humans; Hydatidiform Mole; Methotrexate; Moles; Neoplasms; Pregnancy; Pregnancy Complications; Uterine Neoplasms | 1964 |
CURRENT STATUS OF CHEMOTHERAPY OF CANCER.
Topics: Alkylating Agents; Anti-Bacterial Agents; Antineoplastic Agents; Black People; Chemotherapy, Cancer, Regional Perfusion; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Dermatologic Agents; DNA; DNA, Neoplasm; Fluorouracil; Geriatrics; Humans; Mechlorethamine; Melphalan; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Pharmacology; Thiotepa; Toxicology; Triethylenemelamine; Vinblastine; Vincristine | 1964 |
NEUROBLASTOMA AND WILMS'S TUMOR IN INFANTS AND CHILDREN.
Topics: Adolescent; Child; Cyclophosphamide; Humans; Infant; Mechlorethamine; Methotrexate; Muscle Proteins; Neoplasm Metastasis; Neoplasms; Nephrectomy; Neuroblastoma; Pathology; Prognosis; Toxicology; Wilms Tumor | 1964 |
CLINICAL MANAGEMENT OF SOFT PART SARCOMAS.
Topics: Chlorambucil; Dactinomycin; Geriatrics; Humans; Leiomyosarcoma; Liposarcoma; Liver Neoplasms; Methotrexate; Neoplasms; Palliative Care; Pathology; Pelvic Neoplasms; Radiography, Thoracic; Rhabdomyosarcoma; Sarcoma; Surgical Procedures, Operative; Thigh | 1964 |
REGIONAL ARTERIAL INFUSION FOR LOCALIZED MALIGNANCIES.
Topics: Blood Platelet Disorders; FIGLU Test; Histidine; Humans; Infusions, Intra-Arterial; Injections; Injections, Intra-Arterial; Leucovorin; Methotrexate; Neoplasms; Pathology; Perfusion; Thrombocytosis; Toxicology | 1964 |
THE USE OF HUMAN TUMOR EFFUSIONS IN PRIMARY CULTURE FOR TESTING CHEMOTHERAPEUTIC COMPOUNDS. A PRELIMINARY REPORT.
Topics: Antineoplastic Agents; Mechlorethamine; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Research; Tissue Culture Techniques | 1964 |
THE INTRALYMPHATIC ADMINISTRATION OF RADIOACTIVE ISOTOPES AND CANCER CHEMOTHERAPEUTIC DRUGS.
Topics: Abdominal Neoplasms; Angiography; Breast Neoplasms; Geriatrics; Gold; Humans; Injections; Iodine Isotopes; Leukemia; Lymphatic Metastasis; Lymphatic System; Lymphography; Lymphoma; Lymphoma, Non-Hodgkin; Melanoma; Melphalan; Methotrexate; Neoplasms; Radioisotopes; Radionuclide Imaging; Retroperitoneal Neoplasms; Scandium; Thiotepa; Yttrium | 1964 |
THE USE OF CHEMOTHERAPEUTIC AGENTS IN THE TREATMENT OF CHILDHOOD CANCER.
Topics: Adrenal Cortex Hormones; Antimetabolites; Antineoplastic Agents; Child; Hodgkin Disease; Humans; Infant; Leukemia; Lymphatic Metastasis; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Nitrogen Mustard Compounds; Toxicology; Vincristine | 1964 |
[ACTION OF COMBINED TRIPLE ANTICANCER CHEMOTHERAPY. STUDY ON 32 PATIENTS].
Topics: Adolescent; Anti-Bacterial Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Therapy, Combination; Geriatrics; Methotrexate; Neoplasms; Toxicology | 1964 |
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; Chromosomes, Human; Endometriosis; Female; Fluorouracil; Geriatrics; Humans; Leukocytes; Melanoma; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Ovarian Neoplasms; Sarcoma; Thiotepa; Uterine Cervical Neoplasms; Uterine Neoplasms; Vinblastine | 1964 |
CYCLOPHOSPHAMIDE THERAPY IN CHILDHOOD NEUROBLASTOMA.
Topics: Child; Cyclophosphamide; Dactinomycin; Humans; Infant; Mechlorethamine; Methotrexate; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Retroperitoneal Neoplasms; Toxicology; Urography; Vitamin B 12 | 1964 |
A DIRECT ASSAY FOR DIHYDROFOLATE REDUCTASE IN HUMAN LEUKOCYTES.
Topics: Animals; Chemistry Techniques, Analytical; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Leukemia, Myeloid; Leukocytes; Methotrexate; Mice; Microchemistry; NADP; Neoplasms; Oxidoreductases; Research; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1964 |
THE ADMINISTRATION OF CHEMO-THERAPEUTIC AGENTS IN THE TREATMENT OF ADVANCED HEAD AND NECK CANCER.
Topics: Alkylating Agents; Antineoplastic Agents; Aorta; Aorta, Abdominal; Black People; Catheterization; Ethoglucid; Facial Neoplasms; Floxuridine; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Kenya; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Palliative Care; Surgical Procedures, Operative; Toxicology | 1964 |
SHISHIDO RM: HEADACHE, VOMITING AND HEMIPLEGIA.
Topics: Brain Neoplasms; Cerebral Angiography; Cerebral Hemorrhage; Choriocarcinoma; Chorionic Gonadotropin; Diagnosis, Differential; Female; Gonadotropins; Headache; Hemiplegia; Humans; Intracranial Aneurysm; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Neoplasms; Neurosurgery; Pathology; Pregnancy; Radiography, Thoracic; Urine; Uterine Neoplasms; Vomiting | 1964 |
THERAPEUTIC AND IMMUNOLOGICAL RESPONSE OF MICE WITH MENINGEAL LEUKEMIA (L1210) TO CHALLENGE WITH AN ANTIFOLIC-RESISTANT VARIANT.
Topics: Animals; Cyclophosphamide; Folic Acid Antagonists; Leukemia; Leukemia L1210; Leukemia, Experimental; Meninges; Methotrexate; Mice; Neoplasms; Pathology; Radiation Effects; Research | 1964 |
STUDIES ON HUMAN MELANOMA CELLS IN TISSUE CULTURE. II. EFFECTS OF SEVERAL CANCER CHEMOTHERAPEUTIC AGENTS ON CYTOLOGY AND GROWTH.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chlorambucil; Dactinomycin; Fluorouracil; Melanoma; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Pharmacology; Thiotepa; Tissue Culture Techniques | 1964 |
THE CORRELATION BETWEEN TRANSPLANTED MOUSE AND HUMAN ACUTE LEUKEMIAS.
Topics: Aldehydes; Anilides; Animals; Antineoplastic Agents; Cyclophosphamide; Humans; Leukemia; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Vincristine | 1964 |
THE CLINICAL EFFECTS OF THE CONTINUOUS INTRAVENOUS INFUSION OF CANCER CHEMOTHERAPEUTIC COMPOUNDS.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Floxuridine; Fluorouracil; Infusions, Intravenous; Infusions, Parenteral; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Thymidine | 1964 |
DYNAMICS OF ARTERIAL CIRCULATION OF PELVIS AS RELATED TO CHEMOTHERAPY OF BLADDER CANCER: EXPERIMENTAL AND CLINICAL STUDY.
Topics: Facial Neoplasms; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasms; Pelvis; Sarcoma; Urinary Bladder Neoplasms | 1964 |
PROTRACTED ARTERIAL INFUSION CANCER CHEMOTHERAPY.
Topics: Adenocarcinoma; Carcinoma; Carcinoma, Squamous Cell; Carotid Arteries; Catheterization; Colonic Neoplasms; Floxuridine; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Neoplasms; Pelvic Neoplasms; Skull Neoplasms; Tongue Neoplasms | 1964 |
LEUKEMIA.
Topics: Antineoplastic Agents; Blood Transfusion; Bone Marrow Transplantation; Child; Chromosome Aberrations; Humans; Infections; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Mortality; Neoplasms; Oncogenic Viruses; Research | 1964 |
CHORIOCARCINOMA AND RELATED TROPHOBLASTIC TUMORS IN WOMEN.
Topics: Abortion, Induced; Choriocarcinoma; Female; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Hysterectomy; Methotrexate; Neoplasm Metastasis; Neoplasms; Pregnancy; Pregnancy Complications; Toxicology; Trophoblastic Neoplasms; Uterine Neoplasms | 1964 |
CARCINOMA OF THE LARYNX--REVIEW OF 100 CASES.
Topics: Aged; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Classification; Electronic Data Processing; Hoarseness; Humans; Laryngeal Neoplasms; Laryngectomy; Larynx; Methotrexate; Neck Dissection; Neoplasm Metastasis; Neoplasms; Pathology; Radiography; Radioisotope Teletherapy; Speech Therapy; Toxicology | 1964 |
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neoplasms, Female; Humans; In Vitro Techniques; Intestinal Neoplasms; Leukemia; Mechlorethamine; Melanoma; Mercaptopurine; Methotrexate; Neoplasms; Pharyngeal Neoplasms; Respiratory Tract Neoplasms; Stomach Neoplasms; Thiotepa | 1964 |
ANGIOGRAPHY IN HYDATIDIFORM MOLE AND CHORION EPITHELIOMA.
Topics: Angiography; Choriocarcinoma; Chorion; Female; Humans; Hydatidiform Mole; Mercaptopurine; Methotrexate; Neoplasms; Pregnancy; Surgical Procedures, Operative; Uterine Neoplasms; Vinblastine | 1964 |
REGIONAL CHEMOTHERAPY OF HEAD AND NECK CANCER.
Topics: Antineoplastic Agents; Facial Neoplasms; Geriatrics; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Mouth Neoplasms; Neoplasms; Toxicology | 1964 |
CARCINOMA OF THE COLON IN ULCERATIVE COLITIS.
Topics: Aged; Aging; Cell Biology; Colitis; Colitis, Ulcerative; Colonic Neoplasms; Fluorouracil; Humans; Mechlorethamine; Methotrexate; Neoplasms; Pathology; Polyps; Radiography; Surgical Procedures, Operative | 1964 |
[LABORATORY TESTS FOR VERIFYING STATES OF FOLIC ACID DEFICIENCY IN THE ORGANISM].
Topics: Aminopterin; Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood; Clinical Laboratory Techniques; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Lactobacillus; Leuconostoc; Liver Diseases; Methotrexate; Neoplasms; Nutrition Disorders; Pregnancy; Staphylococcus; Urine; Vitamin B Deficiency | 1964 |
DRUG ASSAYS ON ORGAN CULTURES OF BIOPSIES FROM HUMAN TUMOURS.
Topics: Antineoplastic Agents; Biological Assay; Biopsy; Humans; Melphalan; Methotrexate; Myxosarcoma; Neoplasms; Nucleic Acids; Organ Culture Techniques; Phosphates; Phosphorus Isotopes; Silicones; Tissue Culture Techniques | 1964 |
[ANTITUMOR CHEMOTHERAPY IN THE TREATMENT OF MALIGNANT NEOPLASMS OF THE OVARY].
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Carcinoma; Cyclophosphamide; Female; Humans; Methotrexate; Neoplasms; Ovarian Neoplasms; Radium; Surgical Procedures, Operative; Thiotepa | 1964 |
JET INJECTION OF DRUGS INTO MALIGNANT NEOPLASMS.
Topics: Breast Neoplasms; Drug Therapy; Equipment and Supplies; Humans; Injections; Injections, Jet; Melanoma; Methotrexate; Mouth Neoplasms; Neoplasms; Thiotepa | 1964 |
[REGIONAL CHEMOTHERAPY OF MALIGNANT TUMORS. I. PROLONGED INTRA-ARTERIAL INFUSION OF ANTIMETABOLITES].
Topics: Antimetabolites; Catheterization; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Injections; Injections, Intra-Arterial; Mandibular Neoplasms; Maxillary Neoplasms; Methotrexate; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasms; Tongue Neoplasms; Uterine Cervical Neoplasms | 1964 |
TREATMENT OF CANCER OF THE HEAD AND NECK BY CHEMOTHERAPY.
Topics: Alopecia; Diarrhea; Erythema; Head; Head and Neck Neoplasms; Injections, Intra-Arterial; Leukopenia; Mechlorethamine; Methotrexate; Mucous Membrane; Neoplasms; Stomatitis; Thrombocytopenia; Toxicology; Ulcer; Urticaria | 1964 |
[LONG-TERM REMISSIONS OF ACUTE LEUKEMIAS IN CHILDHOOD].
Topics: Adolescent; Child; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Prognosis | 1964 |
TECHNIC AND TREATMENT OF TUMORS OF THE HEAD AND NECK BY TEMPORAL ARTERY INFUSION.
Topics: Carcinoma; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Geriatrics; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Laryngeal Neoplasms; Leucovorin; Maxillary Neoplasms; Methotrexate; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasms; Orbital Neoplasms; Palatal Neoplasms; Temporal Arteries; Tongue Neoplasms; Toxicology | 1964 |
CONTINUOUS INTRA-ARTERIAL INFUSION OF METHOTREXATE FOR RECURRENT SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK.
Topics: Carcinoma; Carcinoma, Squamous Cell; Cell Division; DNA; DNA, Neoplasm; Drug Therapy; Folic Acid Antagonists; Head; Head and Neck Neoplasms; Infusions, Intra-Arterial; Infusions, Parenteral; Methotrexate; Neoplasms; Squamous Cell Carcinoma of Head and Neck; Surgical Procedures, Operative; Temporal Arteries; Toxicology | 1964 |
THE MANAGEMENT OF LEUKEMIA AND LYMPHOMA.
Topics: Adrenal Cortex Hormones; Busulfan; Chlorambucil; Cortisone; Cyclophosphamide; Hodgkin Disease; Humans; Leukemia; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Mercaptopurine; Methotrexate; Neoplasms; Palliative Care; Sarcoma; Vinblastine | 1964 |
THE TREATMENT OF CANCER BY ISOLATION PERFUSION.
Topics: Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Cyclophosphamide; Fluorouracil; Mechlorethamine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Nursing; Thiotepa; Toxicology | 1964 |
CHORIOEPITHELIOMA IN A FIFTEEN-YEAR-OLD MALE.
Topics: Adolescent; Antineoplastic Agents; Choriocarcinoma; Female; Hemoptysis; Humans; Lung Neoplasms; Mediastinal Neoplasms; Methotrexate; Neoplasm Metastasis; Neoplasms; Pathology; Pregnancy; Radiography, Thoracic | 1964 |
A TECHNIQUE FOR PROLONGED CONTINUOUS INTRA-ARTERIAL INFUSION IN RABBITS. METHOD FOR THE COMPARISON OF THE EFFECTS OF ANTICANCER DRUGS BY CONTINUOUS INTRA-ARTERIAL INFUSION IN THE RABBIT BEARING VX2 CARCINOMAS IN EACH HIND LIMB.
Topics: Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Femoral Artery; Gangrene; Infusions, Intra-Arterial; Infusions, Parenteral; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Experimental; Rabbits; Research; Toxicology; Vincristine | 1964 |
[REGIONAL INTRA-ARTERIAL CYTOSTATIC THERAPY OF MALIGNANT TUMORS OF THE HEAD AND NECK].
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Methotrexate; Neoplasms; Paranasal Sinus Neoplasms; Skin Neoplasms | 1964 |
ULTRA-CLEAN WARD FOR CANCER CHEMOTHERAPY.
Topics: Air Conditioning; Antisepsis; Choriocarcinoma; Female; Hospital Design and Construction; Hospital Planning; Humans; Intensive Care Units; Mercaptopurine; Methotrexate; Neoplasms; Nursing Service, Hospital; Pregnancy | 1964 |
[ACUTE MYELOBLASTIC LEUKEMIA WITH PROLONGED COURSE AND ISOLATED AND LATE ENCEPHALO-MENINGEAL LOCALIZATION].
Topics: Bone Marrow Examination; Brain Neoplasms; Cerebrospinal Fluid Proteins; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Meninges; Mercaptopurine; Methotrexate; Neoplasms; Prednisone | 1964 |
EXPERIMENTAL CHEMOTHERAPY STUDIES. V. THE COLLATERAL SENSITIVITY TO ALKYLATING AGENTS OF SEVERAL ANTIMETABOLITE-RESISTANT ASCITES TUMORS IN MICE.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ascites; Azaserine; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Pharmacology; Research; Thioguanine; Thiotepa; Toxicology | 1964 |
EFFECT OF HYPERBARIC OXYGEN AND CANCER CHEMOTHERAPY ON GROWTH OF ANIMAL TUMORS.
Topics: Animals; Cricetinae; Humans; Hyperbaric Oxygenation; Injections, Intraperitoneal; Lung Neoplasms; Mechlorethamine; Melanoma; Methotrexate; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Pathology; Peritoneal Cavity; Research | 1964 |
THERAPEUTIC CONSIDERATIONS IN TUMORS AFFECTING THE CENTRAL NERVOUS SYSTEM: EPENDYMOMAS.
Topics: Adolescent; Brain Neoplasms; Calcinosis; Child; Cyclophosphamide; Ependymoma; Humans; Methotrexate; Neoplasms; Neurosurgery; Pathology; Radiography; Radiotherapy Dosage | 1964 |
ANTI-LEUKAEMIC DRUGS.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Mustard Plant; Neoplasms; Splenomegaly; Steroids; Uracil | 1964 |
OVARIAN DISGERMINOMA. REPORT OF A CASE TREATED WITH ACTINOMYCIN D, CHLORAMBUCIL, AND METHOTREXATE AFTER MASSIVE IRRADIATION.
Topics: Chlorambucil; Dactinomycin; Drug Therapy; Dysgerminoma; Female; Humans; Methotrexate; Neoplasms; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Prognosis | 1964 |
OBSERVATIONS ON THE USE OF CANCER CHEMOTHERAPEUTIC AGENTS IN PATIENTS WITH MYCOSIS FUNGOIDES.
Topics: Alkylating Agents; Anti-Bacterial Agents; Antineoplastic Agents; Carbamates; Chlorambucil; Dactinomycin; Drug Therapy; Fluorouracil; Humans; Methotrexate; Mitomycin; Mitomycins; Mycosis Fungoides; Neoplasms; Palliative Care; Skin Neoplasms; Thiotepa; Tissue Culture Techniques; Vinblastine | 1964 |
PLASMA CELL NEOPLASM ARISING IN A CAF MOUSE. CHARACTERISTICS AND RESPONSE TO CERTAIN CHEMOTHERAPEUTIC AGENTS.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Antineoplastic Agents; Bence Jones Protein; Cecum; Cyclophosphamide; gamma-Globulins; Intestinal Neoplasms; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Multiple Myeloma; Neoplasms; Neoplasms, Experimental; Neoplasms, Plasma Cell; Pathology; Pharmacology; Prednisolone; Radiation Effects; Research | 1964 |
PRIMARY CARCINOMA ARISING IN NORMAL LIVER IN A BOY AGED 7.
Topics: Carcinoma; Carcinoma, Hepatocellular; Child; Diagnosis, Differential; Hepatectomy; Humans; Liver Neoplasms; Male; Methotrexate; Neoplasms; Pathology; Teratoma | 1964 |
[STUDIES ON CONTINUOUS INTRA-HYPOGASTRIC ARTERIAL INFUSION OF ANTICARCINOGENIC AGENTS IN PATIENTS WITH CERVICAL CANCER AS A SUPPLEMENTARY THERAPY TO SURGICAL OPERATION].
Topics: Anticarcinogenic Agents; Cyclophosphamide; Dogs; Drug Therapy; Female; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Methotrexate; Mitomycin; Mitomycins; Neoplasms; Research; Surgical Procedures, Operative; Toxicology; Uterine Cervical Neoplasms | 1964 |
TECHNIQUE FOR INFUSION AND VISUALIZATION OF THE BRANCHES OF THE EXTERNAL CAROTID ARTERY.
Topics: Antineoplastic Agents; Carotid Arteries; Carotid Artery, External; Chemotherapy, Cancer, Regional Perfusion; Drug Therapy; Head and Neck Neoplasms; Humans; Methotrexate; Neoplasms; Temporal Arteries; Toxicology | 1964 |
EXPERIENCES WITH CHEMOTHERAPY IN GYNECOLOGIC CANCER.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Cyclophosphamide; Dactinomycin; Female; Genital Neoplasms, Female; Humans; Hydroxyprogesterones; Mechlorethamine; Methotrexate; Neoplasms; Ovarian Neoplasms; Pregnancy; Sarcoma; Thiotepa; Toxicology; Trophoblastic Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Vincristine | 1964 |
REGRESSION OF METASTATIC HEPATOMEGALY FROM MAMMARY CARCINOMA. CYTOTOXIC COMBINATION CHEMOTHERAPY WITH 5-FU.
Topics: Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Hepatomegaly; Humans; Liver Neoplasms; Methotrexate; Neoplasm Metastasis; Neoplasms; Prednisone; Testosterone; Thiotepa; Toxicology; Vitamin B 12 | 1964 |
COMBINATION OF SURGERY AND CHEMOTHERAPY IN THE TREATMENT OF ORAL CANCER.
Topics: DNA; DNA, Neoplasm; Drug Therapy; Fluorouracil; Humans; Methotrexate; Mouth Neoplasms; Neck Dissection; Neoplasms; Surgical Procedures, Operative; Thymidine | 1964 |
METHOTREXATE THERAPY OF CHORIOCARCINOMA AND ALLIED TUMORS.
Topics: Choriocarcinoma; Chorionic Gonadotropin; Female; Gonadotropins; Humans; Hydatidiform Mole, Invasive; Hysterectomy; Methotrexate; Neoplasm Metastasis; Neoplasms; Pregnancy; Toxicology; Uterine Neoplasms | 1964 |
OSTEOGENIC SARCOMA OF THE MANDIBLE. REPORT OF CASE TREATED BY RADIATION AND CHEMOTHERAPY.
Topics: Bone Neoplasms; Cobalt Isotopes; Dactinomycin; Drug Therapy; Humans; Mandible; Mandibular Neoplasms; Melphalan; Methotrexate; Neoplasms; Osteomyelitis; Osteosarcoma; Pathology; Radiography; Radium; Sarcoma | 1964 |
THE EFFECT OF 1-BETA-D-ARABINOFURANOSYLCYTOSINE HYDROCHLORIDE ON MURINE NEOPLASMS.
Topics: Animals; Anti-Bacterial Agents; Antibodies; Antineoplastic Agents; Blood Cells; Carcinoma, Ehrlich Tumor; Cortisone; Cytarabine; Cytosine; Leukemia L1210; Leukemia, Experimental; Lymphoma; Mercaptopurine; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 180 | 1964 |
CANCER CHEMOTHERAPY BY CONTINUOUS INTRA-ARTERIAL INFUSION. EXPERIENCE OF THE VETERANS ADMINISTRATION SURGICAL ADJUVANT CANCER CHEMOTHERAPY INFUSION STUDY GROUP.
Topics: Floxuridine; Geriatrics; Hemiplegia; Hemorrhage; Infusions, Intra-Arterial; Infusions, Parenteral; Leucovorin; Mechlorethamine; Methotrexate; Mortality; Neoplasms; Thiotepa; Toxicology; United States; United States Department of Veterans Affairs | 1964 |
COMPLICATIONS INHERENT IN CONTINUOUS INTRA-ARTERIAL CHEMOTHERAPY OF HEAD AND NECK CARCINOMA.
Topics: Carcinoma, Squamous Cell; Cerebrovascular Disorders; Embolism, Air; Head; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Myocardial Infarction; Neoplasms; Pneumonia; Pulmonary Atelectasis; Pulmonary Embolism; Sepsis; Squamous Cell Carcinoma of Head and Neck; Thrombophlebitis | 1964 |
[TREATMENT OF UTERINE SARCOMA WITH METHOTREXATE].
Topics: Drug Therapy; Female; Humans; Methotrexate; Muscle Neoplasms; Neoplasms; Sarcoma; Uterine Neoplasms | 1964 |
EFFECT OF 5',5',5'-TRIFLUOROLEUCINE ON A NUMBER OF MOUSE LEUKAEMIAS.
Topics: Amino Acids; Animals; Chromatography; Hair; Leucine; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Lymphoma; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Pharmacology; Proteins; Research; Skin | 1964 |
METHOTREXATE AND RADIATION IN THE TREATMENT OF PATIENTS WITH CANCER.
Topics: Blood Cell Count; Carcinoma; Carcinoma, Squamous Cell; Cobalt Isotopes; Geriatrics; Head and Neck Neoplasms; Humans; Methotrexate; Neoplasms; Radioisotope Teletherapy; Toxicology | 1964 |
[STUDY OF FACTORS INFLUENCING SURVIVAL IN ACUTE LEUKEMIAS].
Topics: Adolescent; Adrenal Cortex Hormones; Child; Drug Therapy; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Neoplasms; Prednisone | 1964 |
INTRA-ARTERIAL CYTOTOXIC THERAPY AND X-RAY THERAPY FOR CANCER.
Topics: Arm; Carcinoma; Carcinoma, Squamous Cell; Drug Therapy; Humans; Injections, Intra-Arterial; Mechlorethamine; Methotrexate; Neoplasms; Sarcoma; Tongue Neoplasms; X-Ray Therapy | 1965 |
CLOSED PELVIC PERFUSION: ISOLATION PERFUSION OF THE PELVIS WITHOUT CELIOTOMY.
Topics: Catheterization; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Drug Therapy; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms; Pelvic Neoplasms; Pelvis; Perfusion; Tourniquets | 1964 |
ASSOCIATION OF HERPES ZOSTER WITH LEUKEMIA AND LYMPHOMA IN CHILDREN.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Child; Cyclophosphamide; Drug Therapy; Herpes Zoster; Hodgkin Disease; Leukemia; Lymphoma; Mechlorethamine; Mercaptopurine; Methotrexate; Neoplasms; Prednisolone; Surgical Procedures, Operative; Thrombocytopenia | 1965 |
MATERNAL DEATHS DUE TO TROPHOBLASTIC TUMORS.
Topics: Asia, Southeastern; Choriocarcinoma; Drug Therapy; Female; Maternal Death; Maternal Mortality; Methotrexate; Minnesota; Neoplasms; Pregnancy; Surgical Procedures, Operative; Toxicology; Trophoblastic Neoplasms | 1964 |
RADIATION AND DRUG INDUCED HYALINIZATION OF THE STOMACH.
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Drug Therapy; Ganglioneuroma; Gastrointestinal Diseases; Hodgkin Disease; Leukemia; Leukemia, Myeloid; Liver Neoplasms; Lymphoma; Mechlorethamine; Mercaptopurine; Methotrexate; Neoplasms; Pathology; Radiation Injuries; Stomach; Toxicology; Vinblastine; Vincristine; Wilms Tumor | 1965 |
THE TREATMENT OF ADVANCED CANCER WITH A COMBINATION OF 5-FLUOROURACIL, CYTOXAN, AND METHOTREXATE.
Topics: Cyclophosphamide; Drug Therapy; Fluorouracil; Humans; Methotrexate; Neoplasms; Toxicology | 1964 |
PELVIC PERFUSION AND CARCINOMA OF THE RECTUM.
Topics: Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Equipment and Supplies; Fluorouracil; Humans; Methotrexate; Neoplasm Metastasis; Neoplasms; Nitrogen Mustard Compounds; Palliative Care; Pelvic Neoplasms; Pelvis; Rectal Neoplasms; Rectum; Tourniquets | 1965 |
TOXICITY AND ANTITUMOR EFFECT OF DIVIDED DOSES OF METHOTREXATE.
Topics: Breast Neoplasms; Choriocarcinoma; Drug Therapy; Humans; Methotrexate; Neoplasms; Toxicology | 1965 |
[91 CASES OF CONTINUOUS SIMULTANEOUS POLYCHEMOTHERAPY IN INOPERABLE LUNG CANCERS].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Atropine; Cyclophosphamide; Drug Therapy; Drug Therapy, Combination; Heparin; Humans; Lung Neoplasms; Methotrexate; Mortality; Neoplasms; Toxicology; Vinblastine | 1965 |
CENTRAL NERVOUS SYSTEM INVOLVEMENT BY LEUKEMIA IN CHILDREN. II. THERAPY WITH INTRATHECAL METHOTREXATE.
Topics: Central Nervous System Diseases; Cerebrospinal Fluid Proteins; Child; Drug Therapy; Glucose; Humans; Injections; Injections, Spinal; Intracranial Pressure; Leukemia; Leukocyte Count; Methotrexate; Neoplasms; Spinal Puncture; Toxicology | 1965 |
CENTRAL NERVOUS SYSTEM INVOLVEMENT BY LEUKEMIA IN CHILDREN. I. RELATIONSHIP TO SYSTEMIC LEUKEMIA AND DESCRIPTION OF CLINICAL AND LABORATORY MANIFESTATIONS.
Topics: Antineoplastic Agents; Central Nervous System Diseases; Child; Clinical Laboratory Techniques; Drug Therapy; Headache; Humans; Intracranial Pressure; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Papilledema; Prednisone; Vomiting | 1965 |
COMBINED INTRA-ARTERIAL CHEMOTHERAPY AND RADIATION TREATMENT FOR ADVANCED CERVICAL CARCINOMA. THE MCCALL TECHNIQUE AND RESULTS.
Topics: Chemotherapy, Cancer, Regional Perfusion; Drug Therapy; Drug Therapy, Combination; Female; Fluorouracil; Geriatrics; Humans; Methotrexate; Neoplasms; Toxicology; Uterine Cervical Neoplasms | 1965 |
THE TREATMENT OF CARCINOMA IN DOGS' BLADDERS WITH CYTOTOXIC DRUGS.
Topics: Alkylating Agents; Antineoplastic Agents; Carcinogens; Carcinoma; Chlorambucil; Cyclophosphamide; Dogs; Melphalan; Methotrexate; Naphthalenes; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Pharmacology; Research; Toxicology; Urinary Bladder Neoplasms | 1965 |
THE UTILITY OF A CARCINOGEN-INDUCED RAT MAMMARY CANCER AS A CHEMOTHERAPEUTIC SCREENING DEVICE.
Topics: Animals; Breast Neoplasms; Carcinogens; Cyclophosphamide; Dactinomycin; Diet; Diet Therapy; Humans; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mechlorethamine; Mercaptopurine; Methotrexate; Methylcholanthrene; Neoplasms; Rats; Research; Toxicology | 1965 |
THE INTERPRETATION OF CLINICAL TRIALS.
Topics: Biomedical Research; Biometry; Blood Cell Count; Leukemia; Leukemia, Lymphoid; Lymphocytes; Mathematics; Mercaptopurine; Methotrexate; Neoplasms; Therapeutics | 1965 |
REGIONAL ARTERIAL INFUSION OF ANTIMETABOLITES. AN ANALYSIS OF THE RESULTS OBTAINED IN 33 PATIENTS WITH MALIGNANT TUMORS OF THE HEAD AND NECK.
Topics: Antimetabolites; Carcinoma, Squamous Cell; Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Head and Neck Neoplasms; Humans; Infusions, Intra-Arterial; Injections, Intra-Arterial; Lymphatic Metastasis; Lymphoma; Maxillary Neoplasms; Methotrexate; Mouth Neoplasms; Neoplasms; Nose Neoplasms; Parotid Neoplasms; Pharyngeal Neoplasms; Skin Neoplasms | 1965 |
[ANTI-CANCER CHEMOTHERAPY BY PROLONGED INTRA-ARTERIAL INFUSIONS].
Topics: Adrenal Cortex Hormones; Aminocaproates; Aminocaproic Acid; Anti-Bacterial Agents; Chemotherapy, Cancer, Regional Perfusion; Coagulase; Drug Therapy; Fluorouracil; Folic Acid; Humans; Hydrolases; Infusions, Intra-Arterial; Methotrexate; Neoplasms; Thiotepa; Vitamin B Complex | 1965 |
THE AFRICAN LYMPHOMA: PRELIMINARY OBSERVATIONS ON RESPONSE TO THERAPY.
Topics: Arm; Burkitt Lymphoma; Child; Cyclophosphamide; Drug Therapy; Humans; Lymphoma; Mandibular Neoplasms; Maxillary Neoplasms; Methotrexate; Neoplasms; Orbital Neoplasms; Uganda | 1965 |
TROPHOBLASTIC DISEASE AT UAMC 1940-1964.
Topics: Drug Therapy; Female; Gestational Trophoblastic Disease; Humans; Methotrexate; Neoplasms; Pregnancy; Uterine Neoplasms | 1965 |
HEPATIC TUMOURS IN CHILDHOOD AND THEIR TREATMENT BY MAJOR HEPATIC RESECTION.
Topics: Carcinoma; Carcinoma, Hepatocellular; Child; Hamartoma; Hepatectomy; Humans; Infant; Liver Neoplasms; Methotrexate; Mortality; Neoplasms; Pathology; Postoperative Complications; Prognosis | 1965 |
ACTIVE TUBERCULOSIS IN LEUKEMIA. MALIGNANT LYMPHOMA AND MYELOFIBROSIS.
Topics: Alkylating Agents; Aminopterin; Busulfan; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mechlorethamine; Mercaptopurine; Methotrexate; Multiple Myeloma; Neoplasms; Pathology; Primary Myelofibrosis; Sarcoma; Triethylenemelamine; Tuberculosis; Tuberculosis, Pulmonary; Urethane | 1965 |
THREE SUCCESSFUL PREGNANCIES IN A PATIENT TREATED FOR CHORIOCARCINOMA WITH METHOTREXATE. REPORT OF A CASE AND REVIEW OF THE LITERATURE.
Topics: Choriocarcinoma; Female; Humans; Methotrexate; Neoplasms; Pathology; Pregnancy; Pregnancy Complications | 1965 |
[VERY LONG COMPLETE REMISSIONS OF ACUTE LEUKEMIA].
Topics: Child; Drug Therapy; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Remission Induction | 1965 |
TUMORS OF THE SKIN. IV. DOUBLE-BLIND STUDY ON EFFECTS OF LOCAL ADMINISTRATION OF ANTI-TUMOR AGENTS IN BASAL CELL CARCINOMA.
Topics: Antineoplastic Agents; Carcinoma, Basal Cell; Dactinomycin; Double-Blind Method; Drug Therapy; Fluorouracil; Humans; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Ointments; Skin Neoplasms; Spiramycin; Toxicology | 1965 |
TROPHOBLASTIC TUMOURS IN NORWAY.
Topics: Abortion, Induced; Adolescent; Choriocarcinoma; Female; Humans; Hydatidiform Mole; Hysterectomy; Methotrexate; Neoplasm Metastasis; Neoplasm Regression, Spontaneous; Neoplasms; Norway; Pregnancy; Prognosis; Trophoblastic Neoplasms; Uterine Neoplasms | 1965 |
PYRIMIDINE METABOLISM IN TISSUE CULTURE CELLS DERIVED FROM RAT HEPATOMAS. I. SUSPENSION CELL CULTURES DERIVED FROM THE NOVIKOFF HEPATOMA.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Floxuridine; Fluorouracil; Glycine; Liver Neoplasms; Liver Neoplasms, Experimental; Metabolism; Methotrexate; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimidines; Rats; Research; Serine; Thymidine; Thymidine Kinase; Thymine; Tissue Culture Techniques; Toxicology; Uracil | 1965 |
ADJUVANT TUMOR CHEMOTHERAPY IN ADVANCED HEAD AND NECK CANCER.
Topics: Cobalt Isotopes; Cyclophosphamide; Drug Therapy; Glossectomy; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Laryngectomy; Methotrexate; Neck Dissection; Neoplasms; Pathology; Pharyngeal Neoplasms; Tongue Neoplasms | 1965 |
[CANCER CHEMOTHERAPY BY PROLONGED INTRAARTERIAL INFUSION; TREATMENT WITH METHOTREXATE AND INTERMITTENT INTRAMUSCULAR INJECTION].
Topics: Antineoplastic Agents; Humans; Infusions, Intra-Arterial; Injections; Injections, Intra-Arterial; Injections, Intramuscular; Methotrexate; Neoplasms | 1965 |
TOTAL PERFUSION OF BRAIN WITH CANCER CHEMOTHERAPEUTIC AGENTS.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Carotid Arteries; Catheterization; Cattle; Cerebral Angiography; Chemotherapy, Cancer, Regional Perfusion; Drug Therapy; Leucovorin; Methotrexate; Neoplasms | 1965 |
THE EXCRETION OF CHORIONIC GONADOTROPHIN BY MEN WITH TESTICULAR TUMOURS.
Topics: Anura; Castration; Choriocarcinoma; Chorionic Gonadotropin; Gonadotropins; Humans; Hypophysectomy; Male; Metabolism; Methotrexate; Neoplasms; Testicular Neoplasms; Urine | 1965 |
CHEMOTHERAPY IN TREATMENT OF SOLID TUMOURS OF THE ORAL CAVITY.
Topics: Antimetabolites; Methotrexate; Mouth Neoplasms; Neoplasms; Toxicology | 1965 |
CLOSED PELVIC PERFUSION: A NEW APPROACH TO THE PROBLEM OF ADVANCED GYNECOLOGIC MALIGNANCY.
Topics: Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Drug Therapy; Female; Fluorouracil; Genital Neoplasms, Female; Geriatrics; Humans; Methotrexate; Neoplasm Recurrence, Local; Neoplasms; Palliative Care; Pelvis; Prognosis; Uracil Mustard; Uterine Cervical Neoplasms; Vulvar Neoplasms | 1965 |
[METHOTREXATE AND TUMORS OF THE TROPHOBLAST].
Topics: Drug Therapy; Female; Humans; Methotrexate; Neoplasms; Pregnancy; Trophoblastic Neoplasms; Trophoblasts | 1965 |
PRACTICAL DIFFICULTIES OF CANCER CHEMOTHERAPY BY INTRA-ARTERIAL INFUSION.
Topics: Antineoplastic Agents; Drug Therapy; Geriatrics; Humans; Infusions, Intra-Arterial; Infusions, Parenteral; Methotrexate; Neoplasms | 1965 |
TRIPLE DRUG THERAPY WITH ACTINOMYCIN D (NSC-3053), CHLORAMBUCIL (NSC-3088), AND METHOTREXATE (NSC-740) IN METASTATIC SOLID TUMORS IN CHILDREN.
Topics: Child; Chlorambucil; Dactinomycin; Humans; Infant; Methotrexate; Neoplasms | 1965 |
TUMOUR CHEMOTHERAPY IN CHILDREN.
Topics: Child; Cyclophosphamide; Dactinomycin; Hodgkin Disease; Humans; Hydrazines; Methotrexate; Neoplasm Metastasis; Neoplasms; Nephrectomy; Neuroblastoma; Nitrogen Mustard Compounds; Orbital Neoplasms; Pelvic Neoplasms; Rhabdomyosarcoma; Vinblastine; Vincristine; Wilms Tumor | 1965 |
CARCINOMA OF THE OVARY.
Topics: Adenocarcinoma; Chlorambucil; Dactinomycin; Drug Therapy; Female; Humans; Lung Neoplasms; Methotrexate; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Toxicology | 1965 |
THE COMPARISON OF RADIATION AND ANTIMETABOLITE RESPONSES OF GENETICALLY ALTERED MURINE LEUKEMIC CELLS.
Topics: Animals; Antimetabolites; Chromosomes; Floxuridine; Genetics; Idoxuridine; Leukemia; Leukemia, Experimental; Mast Cells; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Nucleosides; Pharmacology; Pyrimethamine; Radiation Genetics; Research; Tissue Culture Techniques | 1965 |
THERAPY OF ACUTE LEUKEMIA, 1965.
Topics: Acute Disease; Adrenal Cortex Hormones; Androgens; Cyclophosphamide; Humans; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Vincristine | 1965 |
THE PERSISTENCE OF EXTRAMEDULLARY LEUKEMIC INFILTRATES DURING BONE MARROW REMISSION OF ACUTE LEUKEMIA.
Topics: Adolescent; Bone Marrow; Bone Marrow Examination; Child; Humans; Intestines; Kidney; Leukemia; Liver; Lung; Male; Mercaptopurine; Methotrexate; Neoplasms; Pathology; Testis | 1965 |
SEQUENTIAL USE OF METHOTREXATE AND ACTINOMYCIN D IN THE TREATMENT OF METASTATIC CHORIOCARCINOMA AND RELATED TROPHOBLASTIC DISEASES IN WOMEN.
Topics: Choriocarcinoma; Dactinomycin; Drug Therapy; Female; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Methotrexate; Neoplasm Metastasis; Neoplasms; Pregnancy; Toxicology; Trophoblastic Neoplasms; Uterine Neoplasms | 1965 |
[SOME MECHANISMS AND PROBLEMS OF SELECTIVE CHEMOTHERAPY].
Topics: Antineoplastic Agents; Drug Therapy; Humans; Methotrexate; Neoplasms; Nucleosides; Uracil; Uridine | 1965 |
[Abdominal chorio-epithelioma in a man treated with methotrexate].
Topics: Abdomen; Abdominal Neoplasms; Carcinoma; Choriocarcinoma; Folic Acid Antagonists; Methotrexate; Neoplasms | 1959 |
Prevention of hormone-induced hypercalcemia by use of methotrexate.
Topics: Bone and Bones; Bone Neoplasms; Breast; Breast Neoplasms; Calcium; Folic Acid Antagonists; Gonadal Steroid Hormones; Humans; Hypercalcemia; Methotrexate; Neoplasms | 1962 |
[Cancer chemotherapy in the future. Discussion].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Delivery Systems; Fluorouracil; Humans; Leucovorin; Medical Oncology; Methotrexate; Neoadjuvant Therapy; Neoplasms; Palliative Care; Quality of Life | 2003 |
Antibody-directed enzyme-prodrug therapy.
Topics: Animals; Antibodies; Antigens, Neoplasm; Base Sequence; DNA Primers; Enzymes; gamma-Glutamyl Hydrolase; Genetic Engineering; Genetic Therapy; Humans; Methotrexate; Mice; Models, Biological; Neoplasms; Polymerase Chain Reaction; Prodrugs | 2004 |
[44-year-old female patient with cutaneous rash, sore throat, fever and arthritis].
Topics: Adrenal Cortex Hormones; Adult; Arthritis; Diagnosis, Differential; Exanthema; Female; Fever of Unknown Origin; Humans; Immunosuppressive Agents; Infections; Methotrexate; Neoplasms; Pharyngitis; Secondary Prevention; Still's Disease, Adult-Onset; Treatment Failure; Treatment Outcome | 2003 |
A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Cell Division; Cell Line, Tumor; DNA, Complementary; Dose-Response Relationship, Drug; Folic Acid; Gene Deletion; HeLa Cells; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Leucovorin; Membrane Transport Proteins; Methotrexate; Neoplasms; Reduced Folate Carrier Protein; Time Factors; Transfection | 2004 |
Fever as a risk factor causing delayed elimination of methotrexate in pediatric patients receiving high doses of cancer chemotherapy.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Creatinine; Dose-Response Relationship, Drug; Female; Fever; Humans; Infant; Kidney; Male; Methotrexate; Neoplasms; Retrospective Studies; Risk Factors | 2004 |
Dual purpose: some cancer therapies used to treat autoimmune diseases.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Autoimmune Diseases; Clinical Trials as Topic; Cyclophosphamide; Daclizumab; Europe; History, 20th Century; Humans; Immunoglobulin G; Immunosuppressive Agents; Mechlorethamine; Methotrexate; Neoplasms; Rituximab; Warfare | 2004 |
The treatment of neoplastic meningitis.
Topics: Antineoplastic Agents; Cytarabine; Humans; Injections, Intraventricular; Injections, Spinal; Meningitis; Methotrexate; Neoplasms; Prognosis; Thiotepa | 2004 |
Treatment of accidental intrathecal methotrexate overdose with intrathecal carboxypeptidase G2.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Clinical Trials as Topic; Drainage; Drug Overdose; Female; gamma-Glutamyl Hydrolase; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Medication Errors; Methotrexate; Middle Aged; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins | 2004 |
Low tumor cell density environment yields survival advantage of tumor cells exposed to MTX in vitro.
Topics: Adaptation, Physiological; Antimetabolites, Antineoplastic; Cell Count; Cell Survival; Drug Resistance, Neoplasm; HT29 Cells; Humans; Methotrexate; Neoplasms; Osteosarcoma | 2005 |
Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Cell Line, Tumor; Cell Survival; Drug Delivery Systems; Ferric Compounds; Folate Receptors, GPI-Anchored; HeLa Cells; Humans; Hydrogen-Ion Concentration; Lysosomes; Macromolecular Substances; Magnetics; Methotrexate; Models, Biological; Molecular Structure; Muscle Cells; Nanoparticles; Neoplasms; Particle Size; Rats; Receptors, Cell Surface; Structure-Activity Relationship; Surface Properties | 2005 |
Antitumor efficacy of a novel polymer-peptide-drug conjugate in human tumor xenograft models.
Topics: Animals; Antineoplastic Agents; Carbohydrate Sequence; Cell Line, Tumor; Dextrans; Drug Design; Female; Humans; Immunohistochemistry; Intestine, Small; Ki-67 Antigen; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methotrexate; Mice; Mice, SCID; Molecular Sequence Data; Molecular Structure; Neoplasms; Peptides; Treatment Outcome; Weight Loss; Xenograft Model Antitumor Assays | 2006 |
[Infections and lymphoma during prolonged immunosuppression in vascular diseases].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclophosphamide; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Interleukin 1 Receptor Antagonist Protein; Lupus Erythematosus, Systemic; Lymphoma; Methotrexate; Neoplasms; Opportunistic Infections; Receptors, Interleukin-1; Sialoglycoproteins; Tumor Necrosis Factor-alpha; Vasculitis | 2005 |
Preparation and in vitro and in vivo evaluation of technetium-99m-labeled folate and methotrexate conjugates as tumor imaging agents.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Folic Acid; Humans; Isotope Labeling; Methotrexate; Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Technetium; Tissue Distribution | 2006 |
Methotrexate resistance in vitro is achieved by a dynamic selectionprocess of tumor cell variants emerging during treatment.
Topics: Cell Line, Tumor; Cell Proliferation; Chromosomal Instability; Dipyridamole; Drug Resistance, Neoplasm; Genetic Variation; Humans; Methotrexate; Neoplasms; Nucleosides; Selection, Genetic | 2006 |
Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high-dose infusional therapy to cancer patients.
Topics: Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Neoplasms | 2006 |
A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes.
Topics: Animals; Female; Fluorouracil; Folic Acid Antagonists; Humans; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Saccharomyces cerevisiae; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2006 |
Intensity of CNS treatment for pediatric cancer: prediction of social outcomes in survivors.
Topics: Adolescent; Age Factors; Antineoplastic Agents; Central Nervous System; Child; Combined Modality Therapy; Cranial Irradiation; Data Collection; Female; Follow-Up Studies; Humans; Injections, Spinal; Interpersonal Relations; Male; Methotrexate; Neoplasms; Sex Factors; Social Adjustment; Social Behavior; Survivors | 2007 |
The contribution of Gianni Bonadonna to the history of chemotherapy.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Breast Neoplasms; Cisplatin; Dacarbazine; Doxorubicin; Female; Fluorouracil; History, 20th Century; Hodgkin Disease; Humans; Italy; Methotrexate; Neoplasms; Vinblastine | 2007 |
Intrastrand annealing leads to the formation of a large DNA palindrome and determines the boundaries of genomic amplification in human cancer.
Topics: Animals; Base Sequence; CHO Cells; Chromosomes, Human, Pair 1; Cricetinae; Cricetulus; DNA; DNA Damage; Gene Amplification; Genome, Human; Humans; Methotrexate; Molecular Sequence Data; Neoplasms | 2007 |
Therapeutic drug monitoring of methotrexate on the pediatric oncology ward: can blood sampling from central venous accesses substitute for capillary finger punctures?
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Blood Specimen Collection; Capillaries; Catheterization, Central Venous; Child; Child, Preschool; Drug Monitoring; Female; Fingers; Fluorescence Polarization Immunoassay; Humans; Male; Methotrexate; Neoplasms; Oncology Service, Hospital; Pediatrics | 2007 |
Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.
Topics: Adult; Aged; Antineoplastic Agents; Brain; Brain Edema; Capecitabine; Dementia, Vascular; Deoxycytidine; Diffusion Magnetic Resonance Imaging; Energy Metabolism; Female; Fluorouracil; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Infusions, Intravenous; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Neoplasms; Nerve Fibers, Myelinated; Neurologic Examination; Registries; Remission, Spontaneous; Stroke; Tegafur | 2008 |
Behavioral and social outcomes in adolescent survivors of childhood cancer: a report from the childhood cancer survivor study.
Topics: Adolescent; Adolescent Behavior; Antimetabolites, Antineoplastic; Brain; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Male; Mental Disorders; Methotrexate; Neoplasms; Siblings; Social Behavior Disorders; Surveys and Questionnaires | 2007 |
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Estradiol; Gefitinib; Humans; Methotrexate; Mitoxantrone; Neoplasm Proteins; Neoplasms; Paclitaxel; Protein Binding; Quinazolines | 2007 |
Morphine in children with cancer: impact of age, chemotherapy and other factors on protein binding.
Topics: Adolescent; Adult; Age Factors; Analgesics, Opioid; Antineoplastic Agents; Blood Proteins; Child; Child, Preschool; Fatty Acids, Nonesterified; Female; Fetal Blood; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Infant, Newborn; Male; Mercaptopurine; Methotrexate; Middle Aged; Morphine; Morphine Derivatives; Neoplasms; Orosomucoid; Protein Binding; Serum Albumin; Vincristine | 2007 |
Bone-marrow changes in man after treatment with aminopterin, amethopterin, and aminoanfol; with special reference to megaloblastosis and tumor remission.
Topics: Aminopterin; Bone Marrow; Humans; Male; Methotrexate; Neoplasms | 1949 |
Integration of modeling and simulation into hospital-based decision support systems guiding pediatric pharmacotherapy.
Topics: Algorithms; Antimetabolites, Antineoplastic; Bayes Theorem; Child; Clinical Pharmacy Information Systems; Computer Simulation; Decision Support Systems, Clinical; Hospitals, Pediatric; Humans; Medical Records Systems, Computerized; Methotrexate; Neoplasms; Pharmacy Service, Hospital; Philadelphia; Systems Integration | 2008 |
Hematopoietic effects of a folate antagonist in man.
Topics: Adult; Bone Marrow; Erythropoiesis; Humans; Injections, Intra-Arterial; Injections, Intramuscular; Methotrexate; Neoplasms | 1967 |
Inhibition of in vitro lymphocyte transformation during chemotherapy in man.
Topics: Anemia, Hemolytic; Culture Techniques; Cyclophosphamide; Cytarabine; Humans; Immune Tolerance; Lectins; Leukemia; Lymphocytes; Mercaptopurine; Methotrexate; Neoplasms; Prednisolone; Smallpox Vaccine; Uveitis; Vincristine | 1967 |
Chemotherapy for the control of pain in inoperable cancer. A report of intra-arterial infusion in four patients.
Topics: Aged; Fluorouracil; Humans; Injections, Intra-Arterial; Male; Methotrexate; Middle Aged; Neoplasms; Pain | 1967 |
Continuous arterial infusion therapy in malignant disease.
Topics: Humans; Injections, Intra-Arterial; Methotrexate; Neoplasms | 1967 |
Intra-arterial chemotherapy for recurrent neoplasms.
Topics: Antineoplastic Agents; Extracorporeal Circulation; Humans; Injections, Intra-Arterial; Methotrexate; Neoplasms | 1967 |
Cytomegalovirus infection associated with and preceding chronic graft-versus-host disease.
Topics: Adolescent; Adult; Anemia, Aplastic; Bone Marrow Transplantation; Child; Chronic Disease; Cyclosporins; Cytomegalovirus Infections; Female; Gaucher Disease; Graft vs Host Disease; Humans; Male; Methotrexate; Neoplasms | 1984 |
Sister chromatid exchange in childhood malignancies.
Topics: Antineoplastic Agents; Cells, Cultured; Child; Crossing Over, Genetic; Cyclophosphamide; Daunorubicin; Humans; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Neoplasms; Sister Chromatid Exchange; Vincristine | 1983 |
[The meaning of maintenance therapy in oncology].
Topics: Breast Neoplasms; Chlorambucil; Hodgkin Disease; Leukemia, Myeloid, Acute; Lymphoma; Methotrexate; Neoplasm Metastasis; Neoplasms; Palliative Care; Remission, Spontaneous | 1980 |
[Chemotherapy of malignant solid tumors].
Topics: Bleomycin; Breast Neoplasms; Bronchial Neoplasms; Cyclophosphamide; Fluorouracil; Humans; Kidney Neoplasms; Lomustine; Methotrexate; Neoplasm Metastasis; Neoplasms; Remission, Spontaneous; Sarcoma; Vincristine | 1980 |
[Preoperative adjuvant chemotherapy in epidermoid carcinoma of the otorhinolaryngologic region].
Topics: Bleomycin; Carcinoma, Squamous Cell; Cisplatin; Humans; Methotrexate; Neoplasms; Otorhinolaryngologic Diseases; Preoperative Care | 1981 |
[Growth of tumour-cell colonies from human solid tumours (author's transl)].
Topics: Carmustine; Cisplatin; Clone Cells; Doxorubicin; Drug Resistance; Fluorouracil; Humans; In Vitro Techniques; Interferons; Methods; Methotrexate; Neoplasms | 1982 |
Intellectual function after treatment for leukaemia or solid tumours.
Topics: Adolescent; Antineoplastic Agents; Brain; Child; Child, Preschool; Combined Modality Therapy; Developmental Disabilities; Female; Humans; Infant; Injections, Spinal; Intelligence; Intelligence Tests; Leukemia, Lymphoid; Male; Mental Disorders; Methotrexate; Neoplasms; Radiotherapy; Time Factors | 1983 |
Drug resistance in cancer.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Azacitidine; Cisplatin; Cytarabine; Drug Resistance; Fluorouracil; Humans; Methotrexate; Neoplasms | 1984 |
Drug testing using a soft agar stem cell assay on patient and xenograft tumor material.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cisplatin; Colony-Forming Units Assay; Drug Synergism; Etoposide; Female; Granulosa Cell Tumor; Humans; Melphalan; Methotrexate; Mice; Misonidazole; Neoplasm Transplantation; Neoplasms; Ovarian Neoplasms; Transplantation, Heterologous; Tumor Stem Cell Assay; Vinblastine | 1984 |
Renal complications of cytotoxic therapy.
Topics: Animals; Antineoplastic Agents; Asparaginase; Cisplatin; Cyclophosphamide; Cytarabine; Dogs; Fluorouracil; Humans; Kidney Diseases; Methotrexate; Mitomycins; Neoplasms; Nitrosourea Compounds; Plicamycin; Procarbazine; Streptozocin; Syndrome | 1983 |
Use of a human tumor cloning system to evaluate analogs of methotrexate and mitoxantrone.
Topics: Anthraquinones; Antineoplastic Agents; Cell Line; Colony-Forming Units Assay; Drug Evaluation, Preclinical; Humans; Methotrexate; Mitoxantrone; Neoplasms; Quinazolines; Trimetrexate; Tumor Stem Cell Assay | 1984 |
[Pharmacokinetics of methotrexate in rabbits and six neoplastic patients].
Topics: Adolescent; Adult; Animals; Female; Humans; Kinetics; Male; Methotrexate; Neoplasms; Rabbits | 1984 |
[Non-hematologic adverse effects of cytostatic drugs].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Diarrhea; Drug Eruptions; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Nervous System Diseases; Vomiting | 1984 |
No increase in second tumors after cytotoxic chemotherapy for gestational trophoblastic tumors.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Choriocarcinoma; Drug Therapy, Combination; Female; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Leukemia, Myeloid; Methotrexate; Neoplasms; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms | 1983 |
[Effect of IV hydration with sodium bicarbonate on high-dose methotrexate disposition kinetics].
Topics: Adolescent; Adult; Bicarbonates; Bone Neoplasms; Child; Female; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Kinetics; Leukemia, Myeloid, Acute; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Neoplasms; Osteosarcoma; Sodium Bicarbonate | 1984 |
Methotrexate.
Topics: Abnormalities, Drug-Induced; Arthritis; Arthritis, Rheumatoid; Drug Interactions; Humans; Infant, Newborn; Methotrexate; Myositis; Neoplasms; Psoriasis; Rheumatic Diseases | 1984 |
[Platelet function and high-dose methotrexate treatment with citrovorum factor rescue].
Topics: Adult; Blood Coagulation; Blood Platelets; Depression, Chemical; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Platelet Aggregation; Platelet Factor 3 | 1984 |
In vitro drug screening and individualized treatment planning for cancer patients.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation, Preclinical; Female; Humans; Mammary Neoplasms, Experimental; Methotrexate; Neoplasms; Rats; Rats, Inbred Strains; Tamoxifen | 1983 |
Acquired resistance to cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Drug Resistance; Humans; Methotrexate; Mice; Models, Biological; Mutation; Neoplasms | 1984 |
[10 years' use of ftorafur in tumor chemotherapy at the Robert Rössle Institute. A retrospective analysis from the clinical-toxologic point of view].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Lomustine; Male; Methotrexate; Middle Aged; Neoplasms; Retrospective Studies; Tamoxifen; Tegafur; Vinblastine; Vincristine | 1984 |
Effects of combination chemotherapy on immunoregulatory cells in peripheral blood of solid tumor cancer patients: correlation with rebound overshoot immune function recovery.
Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Cell Adhesion; Drug Therapy, Combination; Fluorouracil; Humans; Immunity, Cellular; Indomethacin; Leucovorin; Lymphocyte Activation; Methotrexate; Middle Aged; Mitomycins; Monocytes; Neoplasms; Phytohemagglutinins; T-Lymphocytes, Regulatory; Time Factors | 1981 |
Summary and prospective statement concerning the genitourinary workshop.
Topics: Animals; Antineoplastic Agents; Cisplatin; Cyclophosphamide; Humans; Methotrexate; Neoplasms; Radiation Injuries; Radiotherapy; Radiotherapy Dosage; Streptozocin; Time Factors; Urogenital System | 1981 |
The effect of prior cisplatin therapy on the pharmacokinetics of high-dose methotrexate.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Kinetics; Male; Methotrexate; Neoplasms; Risk; Time Factors | 1984 |
The use of human cancer cell lines as a primary screening system for antineoplastic compounds.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Survival; Colonic Neoplasms; Cytarabine; Drug Evaluation, Preclinical; Drug Resistance; Female; Fluorouracil; Humans; Leukemia; Methotrexate; Neoplasms | 1984 |
[Symposium on conventional, medium-dose and high-dose methotrexate therapy. 6 May 1983, Graz. Report on an interdisciplinary oncology work session for hospital physicians and physicians in specialty and general practice. With the scientific cooperation of
Topics: Humans; Methotrexate; Neoplasms | 1983 |
[Vitamin B12 as a regulator and methotrexate as an antagonist of folic acid metabolism. Pathophysiologic and clinical aspects].
Topics: DNA; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Methotrexate; Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency | 1983 |
Improved therapeutic index with sequential N-phosphonacetyl-L-aspartate plus high-dose methotrexate plus high-dose 5-fluorouracil and appropriate rescue.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Drug Therapy, Combination; Female; Fluorouracil; Leucovorin; Male; Methotrexate; Mice; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1983 |
Methotrexate-induced renal impairment: clinical studies and rescue from systemic toxicity with high-dose leucovorin and thymidine.
Topics: Adolescent; Adult; Child; Creatinine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glomerular Filtration Rate; Humans; Inulin; Kidney Diseases; Kinetics; Leucovorin; Methotrexate; Neoplasms; Thymidine | 1983 |
Molecular mechanisms of cellular resistance to folate analogs.
Topics: Animals; Biological Transport; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 1983 |
Serum profiles and safety of intermediate-dose (500-1,000 mg) methotrexate following IV and IM administration.
Topics: Adult; Aged; Humans; Injections, Intramuscular; Injections, Intravenous; Lymphoma; Methotrexate; Middle Aged; Neoplasms | 1983 |
Frequency of malignant neoplasms in 248 long-term methotrexate-treated psoriatics. A preliminary study.
Topics: Administration, Oral; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Risk; Time Factors | 1983 |
[The use of immunosuppressive drugs in the treatment of rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppressive Agents; Methotrexate; Neoplasms; Risk | 1983 |
Regional cancer chemotherapy.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Humans; Infusions, Intra-Arterial; Injections, Intraperitoneal; Kinetics; Methotrexate; Neoplasms | 1984 |
Gene amplification in drug resistance: of mice and men.
Topics: Animals; Cell Line; Drug Resistance; Gene Amplification; Humans; Leukemia; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Tetrahydrofolate Dehydrogenase | 1984 |
Gene amplification, drug resistance, and cancer.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Resistance; Gene Amplification; Humans; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Oncogenes; Tetrahydrofolate Dehydrogenase | 1984 |
The role of superoxide dismutase and gene amplification in carcinogenesis.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cell Transformation, Viral; Drug Resistance; Enzyme Induction; Gene Amplification; Humans; Methotrexate; Models, Biological; Neoplasms; Oncogenes; Rats; Superoxide Dismutase | 1984 |
Theoretically required urinary flow during high-dose methotrexate infusion.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Kidney; Kinetics; Male; Mathematics; Methotrexate; Neoplasms; Urodynamics | 1984 |
Cancer treatment by methotrexate: rational use following pharmacokinetic study.
Topics: Humans; Injections, Intravenous; Kinetics; Methotrexate; Neoplasms; Radioimmunoassay | 1984 |
The design of rational combination chemotherapy for cancer.
Topics: Antineoplastic Agents; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Neoplasms | 1984 |
Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme.
Topics: Adenosine; Azaserine; Breast Neoplasms; Cell Line; Cell Survival; Humans; Leukemia; Melanoma; Methotrexate; Neoplasms; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Thionucleosides | 1981 |
Central nervous system workshop.
Topics: Animals; Antineoplastic Agents; Central Nervous System; Central Nervous System Diseases; Haplorhini; Humans; Intelligence; Methotrexate; Neoplasms; Radiation Injuries; Radiotherapy; Time Factors | 1981 |
Phase I clinical trial with a combination of methotrexate and mitomycin C.
Topics: Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; Male; Methotrexate; Middle Aged; Mitomycin; Mitomycins; Neoplasms | 1981 |
Use of high-dose oral methotrexate sequenced at 24 hours with 5-FU: a clinical toxicity study.
Topics: Breast Neoplasms; Colonic Neoplasms; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Methotrexate; Neoplasms | 1983 |
Methotrexate metabolism.
Topics: Animals; Erythrocytes; Half-Life; Humans; Kinetics; Methotrexate; Neoplasms; Rats | 1983 |
[Development of antitumor agents: retrospection and perspective].
Topics: Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Drug Resistance; Humans; Methotrexate; Mice; Neoplasms | 1983 |
Plasma levels of 7-hydroxymethotrexate after high-dose methotrexate treatment.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Methotrexate; Middle Aged; Neoplasms | 1983 |
Growth and development of children born to mothers treated with cytotoxic drugs during pregnancy.
Topics: Adolescent; Body Height; Child; Child Development; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Mercaptopurine; Methotrexate; Neoplasms; Pregnancy; Pregnancy Complications | 1982 |
Sister chromatid exchanges in human lymphocytes treated with combinations of cytotoxic drugs.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Child, Preschool; Crossing Over, Genetic; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Lymphocytes; Male; Mechlorethamine; Methotrexate; Middle Aged; Neoplasms; Prednisone; Procarbazine; Sister Chromatid Exchange; Vincristine | 1982 |
Toxicity of anticancer drugs used in children.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Cisplatin; Daunorubicin; Doxorubicin; Humans; Methotrexate; Neoplasms; Teniposide | 1980 |
Effects of 5,8-dideazaisofolic acid (IAHQ) on human tumor cells in culture and on normal and tumor-bearing hamsters.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cytotoxicity, Immunologic; Drug Resistance; Female; Folic Acid Antagonists; Humans; Lymphocyte Activation; Methotrexate; Neoplasms; Osteosarcoma; Pregnancy; Quinazolines; Sarcoma, Experimental | 1982 |
High dose methotrexate with leucovorin rescue. Rationale and spectrum of antitumor activity.
Topics: Adult; Bone Marrow; Bone Neoplasms; Breast Neoplasms; Drug Administration Schedule; Female; Gastrointestinal Neoplasms; Head and Neck Neoplasms; Humans; Kidney; Leucovorin; Lung Neoplasms; Lymphoma; Methotrexate; Neoplasms; Urogenital Neoplasms | 1980 |
[Prevention of methotrexate toxicity during intensive neoplasm treatment].
Topics: Humans; Leucovorin; Methods; Methotrexate; Neoplasms | 1980 |
Biochemical control of high-dose methotrexate/Leucovorin rescue therapy.
Topics: Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Humans; Leucovorin; Methotrexate; Neoplasms; Thymidine; Thymidine Kinase | 1980 |
Long-duration intracavitary infusion of methotrexate with systemic leucovorin protection in patients with malignant effusions.
Topics: Drug Therapy, Combination; Exudates and Transudates; Female; Humans; Infusions, Parenteral; Kinetics; Leucovorin; Methotrexate; Neoplasms | 1981 |
[Treatment of malignant neoplasms in advanced stages with HDMTX-CF Rescue (high-dose methotrexate-citrovorum factor rescue)].
Topics: Adolescent; Adult; Aged; Child; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms | 1981 |
[New anticancer chemotherapy].
Topics: Cisplatin; Humans; Leucovorin; Methotrexate; Neoplasms | 1981 |
[Determination of MTX plasma concentration in cancer patients following administration of HD-MTX-CFR (author's transl)].
Topics: Adolescent; Adult; Animals; Child; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Middle Aged; Neoplasms; Rabbits | 1981 |
Radioimmunoassay of methotrexate, leucovorin, and 5-methyltetrahydrofolate.
Topics: Animals; Chemical Phenomena; Chemistry; Goats; Haptens; Humans; Leucovorin; Methotrexate; Neoplasms; Rabbits; Radioimmunoassay; Sheep; Tetrahydrofolates | 1982 |
Clinical and pharmacological studies of methotrexate-minimal leucovorin rescue plus fluorouracil.
Topics: Adult; Aged; Bone Marrow; Drug Therapy, Combination; Female; Fluorouracil; Half-Life; Humans; Kinetics; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms | 1982 |
Phase I study of high-dose methotrexate with thymidine and low-dose leucovorin.
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Kinetics; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Thymidine | 1982 |
Determination of methotrexate in serum by a rapid, fully mechanized enzyme immunoassay (EMIT).
Topics: Adult; Aminopterin; Autoanalysis; Costs and Cost Analysis; Female; Humans; Immunoenzyme Techniques; Kinetics; Methotrexate; Neoplasms; Osteosarcoma | 1980 |
Whole saliva albumin as an indicator of stomatitis in cancer therapy patients.
Topics: Adolescent; Adult; Albumins; Bone Marrow Transplantation; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Male; Methotrexate; Neoplasms; Radiotherapy; Saliva; Stomatitis | 1981 |
Preparation of 125I-labeled methotrexate and its use in magnetizable particle solid-phase radioimmunoassays.
Topics: Animals; Autoanalysis; Cross Reactions; Humans; Iodine Radioisotopes; Isotope Labeling; Methotrexate; Neoplasms; Rabbits; Radioimmunoassay; Sheep | 1982 |
Competitive protein binding assay of methotrexate.
Topics: Binding, Competitive; Humans; Methotrexate; Neoplasms; Radioligand Assay; Tetrahydrofolate Dehydrogenase | 1982 |
Metastatic mammary carcinoma treated with cytotoxic drugs.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cyclophosphamide; Dog Diseases; Dogs; Drug Therapy, Combination; Female; Lung Neoplasms; Mammary Glands, Animal; Methotrexate; Neoplasms; Vincristine | 1982 |
Transport of folate compounds, pterins and adenine in L1210 mouse leukemia cells.
Topics: Adenine; Animals; Biological Transport; Energy Metabolism; Folic Acid; Leukemia L1210; Membranes; Methotrexate; Mice; Neoplasms; Pterins; Tetrahydrofolate Dehydrogenase | 1982 |
Effect of combination chemotherapy, duration of methotrexate administration, and patient's age on methotrexate pharmacokinetics.
Topics: Acute Disease; Adult; Age Factors; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Half-Life; Humans; Infusions, Parenteral; Kinetics; Leukemia; Methotrexate; Neoplasms | 1982 |
[Cocarcinogen as a factor increasing the incidence of mutation responsible for cellular resistance to antifolates].
Topics: Animals; Cell Survival; Cells, Cultured; Cocarcinogenesis; Drug Resistance; Genes; Humans; Methotrexate; Mice; Mutation; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1982 |
The role of 7-hydroxymethotrexate during methotrexate anti-cancer therapy.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Carcinoma, Squamous Cell; Cells, Cultured; Folic Acid Antagonists; Half-Life; Humans; Hydroxylation; Infusions, Parenteral; Injections, Intravenous; Methotrexate; Neoplasms | 1980 |
[Chemotherapy of malignant tumors with folic acid antagonists].
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Neoplasms | 1980 |
Management of drug toxicities and infections.
Topics: Antineoplastic Agents; Carmustine; Cisplatin; Cyclophosphamide; Dacarbazine; Humans; Infections; Methotrexate; Neoplasms | 1980 |
Renal and metabolic toxicities of cancer chemotherapy.
Topics: Antineoplastic Agents; Cisplatin; Drug Administration Schedule; Electrolytes; Glomerular Filtration Rate; Humans; Kidney Diseases; Methotrexate; Neoplasms; Nitrosourea Compounds; Nucleic Acids; Uric Acid | 1982 |
[Usefulness of the radioimmunologic method in the clinical monitoring of high-dosage methotrexate cancer therapy].
Topics: Humans; Methotrexate; Monitoring, Physiologic; Neoplasms; Radioimmunoassay; Time Factors | 1980 |
Achievement of long duration methotrexate exposure with concurrent low dose thymidine protection: influence of methotrexate pharmacokinetics.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Administration Schedule; Drug Combinations; Drug Evaluation; Female; Half-Life; Humans; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Neoplasms; Thymidine; Time Factors | 1980 |
New chromosome techniques in the study of human neoplasia.
Topics: Adolescent; Adult; Agar; Bone Marrow; Bone Marrow Cells; Cell Line; Chromosome Aberrations; Chromosome Banding; Female; Humans; Leukemia; Lymph Nodes; Lymphocytes; Male; Metaphase; Methotrexate; Neoplasms; Tissue Extracts | 1981 |
Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: possible mechanisms and relevance to tumor promotion.
Topics: Animals; Cell Count; Cell Division; Cell Line; Clone Cells; Dose-Response Relationship, Drug; Drug Resistance; Gene Amplification; Methotrexate; Mice; Neoplasms; Phorbols; Tetradecanoylphorbol Acetate; Tetrahydrofolate Dehydrogenase | 1981 |
[Methotrexate].
Topics: Female; Humans; Kinetics; Male; Methotrexate; Neoplasms | 1981 |
Ocular irritation from high-dose methotrexate therapy: pharmacokinetics of drug in the tear film.
Topics: Adolescent; Adult; Eye; Eye Diseases; Female; Humans; Inflammation; Irritants; Lacrimal Apparatus; Male; Methotrexate; Middle Aged; Neoplasms; Tears; Time Factors | 1981 |
Methotrexate serum and saliva concentrations in patients.
Topics: Aged; Humans; Kinetics; Male; Methotrexate; Middle Aged; Neoplasms; Saliva | 1981 |
Effect of nitrous oxide on human bone marrow cells and its synergistic effect with methionine and methotrexate on functional folate deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bone Marrow; Deoxyuridine; DNA; Drug Synergism; Folic Acid Antagonists; Humans; Methionine; Methotrexate; Methyltransferases; Neoplasms; Nitrous Oxide; Pteroylpolyglutamic Acids; Time Factors | 1981 |
Defective function of granulocytes in patients with cancer.
Topics: Adult; Aged; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Granulocytes; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Uterine Neoplasms | 1981 |
Proceedings of the International Symposium on Methotrexate.
Topics: Animals; Humans; Methotrexate; Neoplasms | 1981 |
Introduction to proceedings: International Symposium on Methotrexate.
Topics: Humans; Methotrexate; Neoplasms | 1981 |
The protein binding of methotrexate in the serum of patients with neoplastic disease.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma; Female; Humans; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasms; Protein Binding; Radioimmunoassay; Serum Albumin; Ultrafiltration | 1981 |
The enhancement effect of irradiation by methotrexate. Report of three complications.
Topics: Aged; Esophagitis; Female; Humans; Inflammation; Male; Methotrexate; Middle Aged; Mucous Membrane; Neoplasms; Radiation Injuries; Radiation-Sensitizing Agents | 1980 |
Is methotrexate carcinogenic?
Topics: Animals; Humans; Methotrexate; Mice; Neoplasms | 1980 |
Clinical and laboratory reevalution of dichloromethotrexate.
Topics: Adult; Aged; Antineoplastic Agents; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms | 1980 |
Comparison of 2- and 3-compartment models for the Bayesian estimation of methotrexate pharmacokinetics.
Topics: Adolescent; Adult; Aged; Bayes Theorem; Female; Humans; Methotrexate; Middle Aged; Neoplasms | 1995 |
Prolonged impairment of hematopoiesis after high-dose therapy followed by autologous bone marrow transplantation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Transplantation; Busulfan; Carmustine; Cell Count; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Etoposide; Female; Follow-Up Studies; Hematopoiesis; Hematopoietic Cell Growth Factors; Humans; Male; Melphalan; Methotrexate; Middle Aged; Mitoxantrone; Multivariate Analysis; Neoplasms; Prognosis; Radiation Injuries; Treatment Outcome; Vincristine; Whole-Body Irradiation | 1995 |
Suramin sodium: pronounced effects on methotrexate transport and anti-folate activity in cultured tumor cells.
Topics: Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Division; Drug Synergism; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Pyrimethamine; Receptors, Cell Surface; Suramin; Tumor Cells, Cultured | 1995 |
Neuropsychologic effects of cranial irradiation, intrathecal methotrexate, and systemic methotrexate in childhood cancer.
Topics: Absenteeism; Adolescent; Analysis of Variance; Central Nervous System Neoplasms; Child; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Humans; Injections, Spinal; Intelligence; Intelligence Tests; Leukemia; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasms; Neuropsychological Tests | 1994 |
Methotrexate-loaded, photosensitized erythrocytes: a photo-activatable carrier/delivery system for use in cancer therapy.
Topics: Animals; Drug Carriers; Erythrocyte Aging; Erythrocyte Transfusion; Erythrocytes; HeLa Cells; Hematoporphyrins; Humans; Methotrexate; Neoplasms; Phototherapy; Rabbits | 1994 |
Long-term experience with low dose methotrexate in rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Remission Induction; Retrospective Studies; Time Factors; Treatment Outcome | 1993 |
Proteinuria due to suboptimal hydration with high-dose methotrexate therapy.
Topics: Adolescent; Bone Neoplasms; Burkitt Lymphoma; Child; Female; Fluid Therapy; Glomerular Filtration Rate; Glucose; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteinuria; Sodium Bicarbonate | 1993 |
Predictors of self-care: a test of Orem's model.
Topics: Activities of Daily Living; Adaptation, Psychological; Affect; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Forecasting; Health Promotion; Humans; Male; Methotrexate; Middle Aged; Models, Nursing; Neoplasms; Nursing Evaluation Research; Power, Psychological; Regression Analysis; Self Care; Social Support; Surveys and Questionnaires | 1993 |
Uridine allows dose escalation of 5-fluorouracil when given with N-phosphonacetyl-L-aspartate, methotrexate, and leucovorin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Drug Synergism; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Mouth Mucosa; Neoplasms; Phosphonoacetic Acid; Stomatitis; Uridine | 1993 |
Methotrexate and misoprostol to terminate early pregnancy.
Topics: Abortifacient Agents; Abortion, Induced; Female; Humans; Methotrexate; Mifepristone; Misoprostol; Neoplasms; Pregnancy | 1996 |
Plasma free iron and chemotherapy toxicity.
Topics: Antineoplastic Agents; Doxorubicin; Free Radicals; Humans; Iron; Iron Chelating Agents; Methotrexate; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transferrin | 1996 |
Intellectual functions in childhood malignant disorders.
Topics: Adolescent; Child; Cranial Irradiation; Cross-Sectional Studies; Disease-Free Survival; Follow-Up Studies; Humans; Injections, Spinal; Intelligence; Intelligence Tests; Methotrexate; Neoplasms; Prognosis | 1995 |
The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Deoxycytidine; Dipyridamole; Doxorubicin; Drug Resistance; Female; Floxuridine; Fluorouracil; Gemcitabine; Humans; Methotrexate; Mice; Mice, Nude; Morpholines; Neoplasms; Neoplasms, Experimental; Protein Binding; Transplantation, Heterologous; Triamterene; Tumor Cells, Cultured; Vincristine | 1995 |
Does exposure to immunosuppressive therapy increase the 10 year malignancy and mortality risks in rheumatoid arthritis? A matched cohort study.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Azathioprine; Cohort Studies; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Neoplasms; Risk Factors; Time Factors | 1996 |
Meta-analyses of randomised trials: when the whole is more than just the sum of the parts.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Chemotherapy, Adjuvant; Cisplatin; Female; Fluorouracil; Humans; Meta-Analysis as Topic; Methotrexate; Neoplasms; Ovarian Neoplasms; Proportional Hazards Models; Randomized Controlled Trials as Topic; Research Design | 1996 |
Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carboxypeptidases; Cattle; Cloning, Molecular; DNA Primers; Enzyme Precursors; Enzyme Stability; Gene Expression; Humans; Kinetics; Methotrexate; Molecular Sequence Data; Neoplasms; Pancreas; Phenylalanine; Prodrugs; Rats; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Substrate Specificity; Temperature | 1996 |
A comparison of single-dose and fractionated total-body irradiation on the development of pneumonitis following bone marrow transplantation.
Topics: Adult; Bone Marrow Transplantation; Combined Modality Therapy; Graft vs Host Disease; Humans; Immunosuppressive Agents; Lung Diseases, Interstitial; Methotrexate; Neoplasms; Risk Factors; Transplantation Conditioning; Whole-Body Irradiation | 1996 |
Hepatic dysfunction following busulfan and cyclophosphamide myeloablation: a retrospective, multicenter analysis.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bone Marrow Transplantation; Busulfan; Child; Child, Preschool; Ciprofloxacin; Cyclophosphamide; Estrogens; Female; Genetic Diseases, Inborn; Graft vs Host Disease; Hepatic Veno-Occlusive Disease; Humans; Immunosuppressive Agents; Incidence; Life Tables; Liver Diseases; Liver Function Tests; Male; Methotrexate; Middle Aged; Multiple Organ Failure; Multivariate Analysis; Neoplasms; Progestins; Retrospective Studies; Risk Factors; Transplantation Conditioning; Vancomycin | 1996 |
Effective clearance of methotrexate using high-flux hemodialysis membranes.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Female; Humans; Male; Membranes, Artificial; Methotrexate; Middle Aged; Neoplasms; Renal Dialysis; Renal Insufficiency | 1996 |
"Rescue" agent may circumvent rare but deadly complication from chemotherapy.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; gamma-Glutamyl Hydrolase; Humans; Kidney; Methotrexate; Neoplasms | 1997 |
Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines.
Topics: Antineoplastic Agents; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Neoplasms; Reduced Folate Carrier Protein; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1997 |
Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer.
Topics: Antimetabolites, Antineoplastic; Central Nervous System; Child; Chromatography, High Pressure Liquid; Cysteine; Excitatory Amino Acids; Homocysteine; Humans; Methotrexate; Neoplasms; Neurotransmitter Agents; Retrospective Studies | 1997 |
Selective tumor apoptosis by MF13, L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester, a new sarcolysin containing tripeptide.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Survival; DNA Fragmentation; DNA, Neoplasm; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Lethal Dose 50; Leukemia; Leukemia L1210; Lymphoma; Melphalan; Methotrexate; Mice; Neoplasms; Oligopeptides; Tumor Cells, Cultured | 1997 |
Cognitive late effect factors related to decision making and risk behaviors of cancer-surviving adolescents.
Topics: Adolescent; Antimetabolites, Antineoplastic; Cognition Disorders; Decision Making; Female; Humans; Male; Methotrexate; Neoplasms; Radiotherapy; Regression Analysis; Risk-Taking | 1997 |
Acute pancreatitis in marrow transplant patients: prevalence at autopsy and risk factor analysis.
Topics: Abdominal Pain; Acute Disease; Adult; Amylases; Bile; Biomarkers; Bone Marrow Transplantation; Cause of Death; Cohort Studies; Cyclosporine; Drug Therapy, Combination; Female; Gallbladder; Graft vs Host Disease; Humans; Immunosuppressive Agents; Male; Methotrexate; Neoplasms; Pancreatitis; Prednisone; Prevalence; Risk Factors; Transplantation Conditioning; Whole-Body Irradiation | 1997 |
Making TDM work to optimize cancer chemotherapy: a multidisciplinary team approach.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Monitoring; Fluorouracil; Humans; Mercaptopurine; Methotrexate; Neoplasms; Outcome Assessment, Health Care | 1998 |
Risk factors for chronic graft-versus-host disease after bone marrow transplantation: a retrospective single centre analysis.
Topics: Adolescent; Adult; Age Factors; Bone Marrow Transplantation; Child; Child, Preschool; Chronic Disease; Cyclosporine; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Infant; Male; Methotrexate; Middle Aged; Neoplasms; Retrospective Studies; Risk Factors; Sex Factors; Transplantation, Homologous | 1998 |
Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Chromatography, Thin Layer; Dogs; Dose-Response Relationship, Drug; Folic Acid Antagonists; Gene Transfer Techniques; Genetic Therapy; Glioma; Humans; Methotrexate; Neoplasms; Peptide Synthases; Rats; Transduction, Genetic; Transfection; Tumor Cells, Cultured | 1999 |
The leucocyte nadir, a predictor of chemotherapy efficacy?
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Monitoring; Female; Fluorouracil; Humans; Leukocyte Count; Leukopenia; Methotrexate; Neoplasms; Predictive Value of Tests | 1999 |
The molecular perspective: methotrexate.
Topics: Antimetabolites, Antineoplastic; Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 1999 |
Outcome of radiation-related osteosarcoma after treatment of childhood and adolescent cancer: a study of 23 cases.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasms; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Osteosarcoma; Radiotherapy Dosage; Rhabdomyosarcoma; Sarcoma, Ewing | 1999 |
Liquid chromatographic analysis and preliminary pharmacokinetics of methotrexate in cancer patients co-treated with docetaxel.
Topics: Acetone; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Chemical Precipitation; Chromatography, High Pressure Liquid; Docetaxel; Humans; Hydroxylation; Kinetics; Methanol; Methotrexate; Neoplasms; Paclitaxel; Rats; Rats, Wistar; Sensitivity and Specificity; Taxoids | 1999 |
Suppressive subtractive hybridisation reveals differential expression of serglycin, sorcin, bone marrow proteoglycan and prostate-tumour-inducing gene I (PTI-1) in drug-resistant and sensitive tumour cell lines of haematopoetic origin.
Topics: Antineoplastic Agents; Blood Proteins; Calcium-Binding Proteins; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Eosinophil Major Basic Protein; Humans; Methotrexate; Neoplasms; Neoplastic Stem Cells; Oncogene Proteins; Peptide Elongation Factor 1; Proteoglycans; Tumor Cells, Cultured; Vesicular Transport Proteins; Vincristine | 1999 |
High-dose methotrexate is lethal to rats. Why give it to children?
Topics: Animals; Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats | 2000 |
In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Cytarabine; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Harringtonines; Homoharringtonine; Humans; Hydroxyurea; Imatinib Mesylate; Interferon-alpha; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methotrexate; Microbial Sensitivity Tests; Neoplasm Proteins; Neoplasms; Piperazines; Pyrimidines; Tumor Cells, Cultured; Vincristine | 2001 |
Clinical tolerance after allogeneic hematopoietic stem cell transplantation: a study of influencing factors.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Follow-Up Studies; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Histocompatibility Testing; Humans; Immune Tolerance; Immunosuppressive Agents; Infant; Male; Methotrexate; Middle Aged; Neoplasms; Nuclear Family; Time Factors; Tissue Donors; Transplantation Chimera; Transplantation, Homologous | 2002 |
[Dermatomyositis and polymyositis: clinical aspects and treatment].
Topics: Anti-Inflammatory Agents; Creatinine; Dermatomyositis; Drug Therapy, Combination; Face; Humans; Immunoglobulins; Immunosuppressive Agents; Methotrexate; Muscle, Skeletal; Neoplasms; Polymyositis; Prednisone | 2001 |
Dihydropyrimidine dehydrogenase enzyme deficiency: clinical and genetic assessment of prevalence in Turkish cancer patients.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; Female; Fluorouracil; Genetics, Population; Humans; Male; Methotrexate; Neoplasms; Oxidoreductases; Prevalence; Turkey | 2002 |
High dose methotrexate treatment and its problems. A workshop held in Sydney, Australia in December 1977.
Topics: Australia; Congresses as Topic; Humans; Methotrexate; Neoplasms | 1979 |
Kinetically-based multiple drug treatment for advanced head and neck cancer.
Topics: Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Ear Neoplasms; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Hydroxyurea; Laryngeal Neoplasms; Maxillary Neoplasms; Mercaptopurine; Methotrexate; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasms; Tongue Neoplasms; Tonsillar Neoplasms; Vincristine | 1975 |
Flow microfluorometric patterns of human bone marrow and tumor cells in response to cancer chemotherapy.
Topics: Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cytarabine; Ethidium; Fluorometry; Humans; Leucovorin; Leukemia, Lymphoid; Melanoma; Methotrexate; Neoplasms; Staining and Labeling | 1976 |
Intrathecal cytostatic therapy of meningeal carcinomatosis. Autoradiographic investigations of the CSF cells.
Topics: Adult; Breast Neoplasms; Cell Count; Cerebrospinal Fluid; DNA, Neoplasm; Female; Humans; Injections, Spinal; Meninges; Methotrexate; Mitosis; Neoplasm Metastasis; Neoplasms | 1976 |
[Pulmonary fibrosis following treatment with cytostatics].
Topics: Antineoplastic Agents; Bleomycin; Busulfan; Humans; Male; Melphalan; Methotrexate; Middle Aged; Neoplasms; Pulmonary Fibrosis | 1976 |
Intravenous bleomycin infusion as a potential syncronizing agent in human disseminated malignancies: a preliminary report.
Topics: Adult; Bleomycin; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; Hydroxyurea; Infusions, Parenteral; Lung Neoplasms; Male; Methotrexate; Neoplasms; Urinary Bladder Neoplasms | 1976 |
Razoxane and methotrexate resistance.
Topics: Cell Line; Cell Survival; Drug Resistance; Humans; Lymphocytes; Methotrexate; Neoplasms; Piperazines; Razoxane | 1977 |
Clinical pharmacology of anticancer drugs.
Topics: Animals; Antineoplastic Agents; Azacitidine; Bleomycin; Cyclophosphamide; Cytarabine; Dacarbazine; Daunorubicin; Doxorubicin; Female; Fluorouracil; Heart; Humans; Leucovorin; Lung; Male; Methotrexate; Neoplasms; Nitrosourea Compounds; Procarbazine; Triazenes; Vinblastine; Vincristine | 1977 |
Dare we count the cost of cancer chemotherapy?
Topics: Antineoplastic Agents; Bleomycin; Cancer Care Facilities; Costs and Cost Analysis; Cyclophosphamide; Doxorubicin; Hospital Bed Capacity, 500 and over; Hospitals, Special; Hospitals, Teaching; Humans; Leucovorin; London; Medication Systems, Hospital; Methotrexate; Neoplasms; Pharmacy Service, Hospital; Vincristine | 1978 |
[Parenteral feeding during aggressive chemotherapy of various neoplasms].
Topics: Adult; Bleomycin; Body Weight; Cachexia; Cyclophosphamide; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasms; Parenteral Nutrition; Vincristine | 1978 |
Acute renal failure associated with neoplastic disease and its treatment.
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Antineoplastic Agents; Cisplatin; Female; Humans; Hypercalcemia; Kidney; Methotrexate; Multiple Myeloma; Myeloma Proteins; Neoplasm Invasiveness; Neoplasms; Radiation Injuries; Streptozocin; Ureteral Obstruction; Uric Acid; Urogenital Neoplasms | 1978 |
From wild fowl to stalking horses: alchemy in chemotherapy. Fifth annual David A. Karnofsky Memorial Lecture.
Topics: Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Asparaginase; Brain Neoplasms; Drug Therapy, Combination; History, 20th Century; Hodgkin Disease; Humans; Infections; Leukemia; Lymphoma; Methotrexate; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Osteosarcoma; Rhabdomyosarcoma; Sarcoma, Ewing; Wilms Tumor | 1975 |
Recent trends in chemotherapy of solid tumors.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Cyclophosphamide; Esophageal Neoplasms; Female; Fluorouracil; Gastrointestinal Neoplasms; Head and Neck Neoplasms; Humans; Liver Neoplasms; Lung Neoplasms; Melanoma; Methotrexate; Neoplasms; Pancreatic Neoplasms; Radiotherapy, High-Energy; Sarcoma; Urogenital Neoplasms | 1975 |
Current status of regional arterial infusion chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carotid Arteries; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Hepatic Artery; Humans; Liver Neoplasms; Melanoma; Methotrexate; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasms; Temporal Arteries; Time Factors | 1975 |
Future prospects for immunotherapy.
Topics: Animals; BCG Vaccine; Carcinoma, Hepatocellular; Dacarbazine; Guinea Pigs; Humans; Immunotherapy; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Liver Neoplasms; Melanoma; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Sarcoma | 1975 |
Childhood cancer: the improving prognosis.
Topics: Asparaginase; Child; Cyclophosphamide; Cytosine; Daunorubicin; Doxorubicin; Drug Therapy, Combination; Hodgkin Disease; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphoma; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Osteosarcoma; Prednisone; Procarbazine; Prognosis; Remission, Spontaneous; Rhabdomyosarcoma; Teniposide; Thioguanine; Vincristine; Wilms Tumor | 1976 |
Cancer chemotherapy.
Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Leukemia, Lymphoid; Male; Methotrexate; Neoplasms; Neuroblastoma; Prednisone; Pregnancy; Procarbazine; Remission, Spontaneous; Testicular Neoplasms; Uterine Neoplasms; Vincristine | 1977 |
Some new aspects of modern cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Survival; Daunorubicin; Drug Therapy, Combination; Humans; Kinetics; Leukemia, Experimental; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Mitosis; Neoplasms; Neuraminidase; Prednisone; Vincristine | 1977 |
Current trends and prospects in surgical adjuvant trials.
Topics: Antineoplastic Agents; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Dianhydrogalactitol; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Melphalan; Methotrexate; Neoplasms; Osteosarcoma; Rectal Neoplasms | 1978 |
High-dose methotrexate therapy.
Topics: Adult; Carcinoma, Squamous Cell; Drug Therapy, Combination; Head and Neck Neoplasms; Humans; Leucovorin; Lymphoma; Methotrexate; Neoplasms | 1977 |
[Therapy of solid tumors using high-dose methotrexate and citrovorum factor].
Topics: Administration, Oral; Adult; Aged; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms | 1977 |
"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.
Topics: Animals; Asparaginase; Breast Neoplasms; Carboxypeptidases; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia; Lung Neoplasms; Lymphoma; Melanoma; Methotrexate; Neoplasms; Osteosarcoma; Tetrahydrofolates; Thymidine | 1977 |
Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration.
Topics: Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; United States | 1977 |
Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity.
Topics: Blood Cell Count; Blood Platelets; Bone Marrow; Creatinine; Humans; Infusions, Parenteral; Kidney; Leucovorin; Leukocyte Count; Methotrexate; Neoplasms; Time Factors | 1977 |
Changes in glomerular filtration rate associated with high-dose methotrexate therapy in adults.
Topics: Adult; Glomerular Filtration Rate; Humans; Infusions, Parenteral; Kidney Glomerulus; Leucovorin; Methotrexate; Neoplasms; Time Factors | 1977 |
Calcium leucovorin - folinic acid rescue.
Topics: Humans; Leucovorin; Methotrexate; Neoplasms | 1978 |
"Single"-agent activity of high-dose methotrexate with citrovorum factor rescue.
Topics: Bone Neoplasms; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Osteosarcoma; Vincristine | 1978 |
High-dose methotrexate with leucovorin rescue.
Topics: Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms | 1978 |
Toward improved selectivity in cancer chemotherapy: the Richard and Hinda Rosenthal Foundation Award Lecture.
Topics: Animals; Antineoplastic Agents; Carboxypeptidases; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Neoplasms; Uracil Nucleotides | 1979 |
The day hospital: ambulatory care for the adolescent with cancer.
Topics: Adolescent; Ambulatory Care; Day Care, Medical; Hospitals, Special; Humans; Leucovorin; Methotrexate; Neoplasms; New York City; Professional-Patient Relations | 1979 |
Cytokinetic comparison of thymidine and leucovorin rescue of marrow in humans after exposure to high-dose methotrexate.
Topics: Bone Marrow; Cell Cycle; DNA, Neoplasm; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Thymidine | 1979 |
A clinical and pharmacological study of high-dose methotrexate with minimal leucovorin rescue.
Topics: Adult; Aged; Bone Marrow; Drug Evaluation; Drug Therapy, Combination; Female; Half-Life; Humans; Infusions, Parenteral; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Stomatitis | 1979 |
High dose methotrexate followed by citrovorum factor reversal in patients with advanced cancer.
Topics: Adolescent; Adult; Aged; Female; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma | 1979 |
Evaluation of 24-hour infusion of high-dose methotrexate--pharmacokinetics and toxicity.
Topics: Adolescent; Adult; Child; Child, Preschool; Creatinine; Humans; Infant; Infusions, Parenteral; Kinetics; Leucovorin; Liver; Methotrexate; Neoplasms; Time Factors | 1979 |
[Method for determination of methotrexate in biological materials].
Topics: Body Fluids; Folic Acid; Humans; Leucovorin; Methods; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 1979 |
[High-dose methotrexate with citrovorum factor rescue in the treatment of malignant tumors (author's transl)].
Topics: Adolescent; Adult; Female; Humans; Leucovorin; Male; Methotrexate; Neoplasms | 1979 |
[Results and pharmacokinetic aspects of methotrexate therapy in high doses].
Topics: Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms | 1979 |
Metabolism of anticancer drugs: a rapid and specific enzyme immunoassay for methotrexate [proceedings].
Topics: Humans; Immunoenzyme Techniques; Methotrexate; Neoplasms | 1978 |
Comparison of intravenous and oral high-dose methotrexate in treatment of solid tumours.
Topics: Administration, Oral; Adult; Biological Availability; Female; Half-Life; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged; Neoplasms | 1979 |
Chemotherapy of common solid tumours in a general surgical unit.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Melanoma; Methotrexate; Middle Aged; Nausea; Neoplasms; Quality of Life; Vincristine; Vomiting | 1979 |
Effect of probenecid on cerebrospinal fluid methotrexate kinetics.
Topics: Adult; Child, Preschool; Female; Humans; Kinetics; Methotrexate; Middle Aged; Neoplasms; Probenecid | 1979 |
Mathematical modeling -- guide to high-dose methotrexate infusion therapy.
Topics: Carcinoma, Squamous Cell; Humans; Kinetics; Laryngeal Neoplasms; Methotrexate; Models, Biological; Neoplasm Metastasis; Neoplasms; Sarcoma, Ewing | 1979 |
Bioavailability of methotrexate: implications for clinical use.
Topics: Administration, Oral; Adult; Aged; Biological Availability; Creatinine; Female; Humans; Kinetics; Male; Methotrexate; Middle Aged; Neoplasms; Time Factors | 1979 |
Accumulation of methotrexate diglutamate in human liver during methotrexate therapy.
Topics: Folic Acid Antagonists; Humans; In Vitro Techniques; Liver; Methotrexate; Neoplasms; Thymidylate Synthase | 1977 |
Drug interactions with antineoplastic agents.
Topics: Adrenal Cortex Hormones; Animals; Antineoplastic Agents; Chloramphenicol; Cyclophosphamide; Drug Interactions; Drug Therapy, Combination; Fluorouracil; Humans; Mercaptopurine; Methotrexate; Mice; Neoplasms; Prednisolone; Rats; Thioguanine; Vinca Alkaloids | 1977 |
[Metabolism of aminoanalogues of folate (author's transl)].
Topics: Acetylation; Amino Acids; Animals; Deamination; Folic Acid; Folic Acid Antagonists; Glutamates; Hydroxylation; Methotrexate; Mice; Neoplasms | 1977 |
An in vitro method to determine the sensitivity of solid malignant tumours to cytostatic agents.
Topics: Antineoplastic Agents; Cells, Cultured; DNA Replication; Fluorouracil; Humans; Methotrexate; Neoplasms; Vincristine | 1977 |
Thymidine rescue of high-dose methotrexate in humans.
Topics: Adult; Aged; Blood Cells; Bone Marrow; DNA; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Neoplasms; Thymidine | 1978 |
Unproven efficacy of vincristine methotrexate combination therapy.
Topics: Cells, Cultured; Drug Therapy, Combination; Humans; Methotrexate; Neoplasms; Vincristine | 1978 |
[Treatment-induced complications and frequent errors in cytostatic therapy].
Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Hypercalcemia; Male; Methotrexate; Middle Aged; Neoplasms; Uric Acid; Vincristine | 1978 |
In vitro sensitivity of cancer cells to antitumor agents.
Topics: Antineoplastic Agents; In Vitro Techniques; Methotrexate; Neoplasms; Time Factors | 1978 |
Tuberculin and dinitrochlorobenzene (DNCB) tests in cancer patients before and after cytostatic drug therapy.
Topics: Cyclophosphamide; Dinitrochlorobenzene; Fluorouracil; Humans; Immunity, Cellular; Methotrexate; Neoplasms; Nitrobenzenes; Skin Tests; Tuberculin Test; Vinblastine | 1978 |
[High dose methotrexate for the therapy of malignant diseases].
Topics: Humans; Methotrexate; Neoplasms | 1978 |
Dermatomyositis: observations on the use of immunosuppressive therapy and review of literature. Cairo--Glasgow study group.
Topics: Adrenal Cortex Hormones; Adult; Cyclophosphamide; Dermatomyositis; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Neoplasms; Prognosis; Time Factors | 1978 |
Rationale of chemotherapeutic adjuvant treatment.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Humans; Leukemia L1210; Lomustine; Mercaptopurine; Methotrexate; Mice; Neoplasms | 1978 |
Some new chemotherapeutic agents and combinations possibly available for new adjuvant therapies of minimal disease.
Topics: Alkylating Agents; Antineoplastic Agents; Doxorubicin; Drug Therapy, Combination; Humans; Methotrexate; Neoplasms; Tubulin Modulators | 1978 |
Interrelationship between chemotherapy and immunotherapy in the treatment of disseminated disease.
Topics: Animals; Carmustine; Dacarbazine; Humans; Immunity; Immunotherapy; Leukemia L1210; Methotrexate; Mice; Mice, Inbred BALB C; Neoplasms | 1978 |
Fresh explant culture of human tumours in vitro and the assessment of sensitivity to cytotoxic chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Culture Techniques; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; Kidney Neoplasms; Melanoma; Methotrexate; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Ovarian Neoplasms; Thiotepa; Vincristine | 1975 |
Immunological overshoot phenomenon following cancer chemotherapy: significance in prognosis evaluation of solid tumors.
Topics: Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immune Adherence Reaction; Liver Neoplasms; Lung Neoplasms; Lymphocyte Activation; Melphalan; Methotrexate; Neoplasms; Ovarian Neoplasms; Thiotepa; Vincristine | 1975 |
[Current progress in cancer therapy].
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Methotrexate; Neoplasms | 1977 |
Combination chemotherapy using cyclophosphamide, vincristine, methotrexate, 5-fluorouracil, and prednisone in solid tumors.
Topics: Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Leukocyte Count; Lung Neoplasms; Male; Methotrexate; Neoplasms; Ovarian Neoplasms; Prednisone; Remission, Spontaneous; Time Factors; Vincristine | 1977 |
The prevention of methotrexate toxicity by thymidine infusions in humans.
Topics: Adult; Aged; Bone Marrow; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Parenteral; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Neoplasms; Thymidine | 1977 |
Rapid assays for evaluating the drug sensitivity of tumor cells.
Topics: Antineoplastic Agents; Ascitic Fluid; Cell Division; Cell Line; Daunorubicin; DNA, Neoplasm; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance; Humans; In Vitro Techniques; Melphalan; Methotrexate; Neoplasms; Phenotype; Pleural Effusion; Puromycin; RNA, Neoplasm; Vinblastine | 1977 |
Ligand-binding radioassay for the antifolate compounds: application in patients receiving methotrexate.
Topics: Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Kidney; Liver; Male; Methods; Methotrexate; Neoplasms; Radioligand Assay; Tetrahydrofolate Dehydrogenase | 1977 |
Quadruple chemotherapy for advanced malignant disease.
Topics: Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Methotrexate; Neoplasms; Remission, Spontaneous; Stomach Neoplasms; Vincristine | 1977 |
Methotrexate and hemodialysis.
Topics: Acute Kidney Injury; Adolescent; Adult; Female; Humans; Male; Methotrexate; Neoplasms; Peritoneal Dialysis; Renal Dialysis | 1977 |
Indication of antitumor agents by microbiologic methods.
Topics: Animals; Antineoplastic Agents; Bacteria; Biological Assay; Female; Fluorouracil; Humans; Kinetics; Male; Methotrexate; Neoplasms | 1977 |
Systemic chemotherapy for psoriasis: a national survey.
Topics: Adult; Azauridine; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Utilization; Female; Humans; Hydroxyurea; Liver; Methotrexate; Neoplasms; Psoriasis; Thrombophlebitis | 1976 |
Inhibition of DNA synthesis in normal and malignant human cells by triazinate (Baker's antifol) and methotrexate.
Topics: Bone Marrow; Bone Marrow Cells; DNA; DNA, Neoplasm; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Neoplasms; Triazines | 1976 |
Lysosomal enzyme activation in irradiated mammary tumors.
Topics: Acid Phosphatase; Aminopeptidases; Animals; Dose-Response Relationship, Radiation; Enzyme Activation; Female; Lysosomes; Mammary Glands, Animal; Methotrexate; Mice; Mice, Inbred C3H; Neoplasms; Oxygen; Testosterone | 1976 |
[Experiences with cytostatic treatment of malignant tumors].
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Neoplasms; Prednisone; Sarcoma; Stomach Neoplasms; Triaziquone; Vincristine | 1976 |
[Cytostatic therapy of inoperable carcinomas].
Topics: Breast Neoplasms; Bronchial Neoplasms; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Methotrexate; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Pregnancy; Procarbazine; Testicular Neoplasms; Vinblastine; Vincristine | 1976 |
[Five years treatment of advanced solid malignomas with a combination of four cytostatic drugs (author's transl)].
Topics: Adult; Aged; Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Ovarian Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Vinblastine | 1976 |
[Tumor-induction through cytostatic agents in man].
Topics: Antineoplastic Agents; Breast Neoplasms; Busulfan; Carcinogens; Cyclophosphamide; Humans; Leukemia, Myeloid; Lung Neoplasms; Melphalan; Methotrexate; Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Triaziquone; Urinary Bladder Neoplasms | 1975 |
Is methotrexate therapy for psoriasis carcinogenic? A modified retrospective-prospective analysis.
Topics: Aged; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Liver; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms; Prospective Studies; Prostatic Neoplasms; Psoriasis; Retrospective Studies; Skin Neoplasms | 1975 |
Relationship between intracellular dihydrofolate reductase and tightly bound intracellular methotrexate in human neoplastic cells.
Topics: Burkitt Lymphoma; Cells, Cultured; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase; Time Factors | 1976 |
New approaches to cancer chemotherapy with methotrexate.
Topics: Adult; Animals; Biological Transport; Bone Marrow; Creatinine; DNA, Neoplasm; Doxorubicin; Drug Therapy, Combination; Humans; Kidney; Leucovorin; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Purines; Thymidine; Thymine Nucleotides | 1975 |
[Immunologic tissue damage and immunosuppression].
Topics: Abnormalities, Drug-Induced; Azathioprine; Cortisone; Cyclophosphamide; Female; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Infections; Infertility; Male; Mercaptopurine; Methotrexate; Neoplasms; T-Lymphocytes | 1976 |
Reactivation of a solar burn with high-dose methotrexate and citrovorum rescue [ letter].
Topics: Female; Humans; Leucovorin; Methotrexate; Neoplasms; Skin Diseases; Sunburn | 1976 |
High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity.
Topics: Adolescent; Adult; Aged; Bone Neoplasms; Drug Therapy, Combination; Humans; Leucovorin; Melanoma; Methotrexate; Middle Aged; Neoplasms; Sarcoma; Soft Tissue Neoplasms | 1976 |
The effect of cytostatic therapy on cellular immunity in vitro.
Topics: Antineoplastic Agents; B-Lymphocytes; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunity, Cellular; Lectins; Leukocyte Count; Lymphocyte Activation; Methotrexate; Neoplasms; T-Lymphocytes; Vinblastine | 1975 |
Approaches to selectivity in cancer chemotherapy.
Topics: Drug Evaluation; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Neoplasms | 1976 |
Systemic chemotherapy of advanced head and neck malignancies.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Imidazoles; Melanoma; Methotrexate; Neoplasms; Nitrosourea Compounds; Retrospective Studies; Sarcoma; Triazenes; Vincristine | 1975 |
Methotrexate and the need for continued research.
Topics: Binding Sites; Binding, Competitive; DNA Replication; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Protein Binding; Receptors, Drug; Research; Thymidylate Synthase | 1975 |
Meningeal mycosis fungoides: clinical and cellular characteristics.
Topics: Animals; Cell Membrane; Cell Nucleus; Central Nervous System Diseases; Cerebrospinal Fluid; Cyclophosphamide; Humans; Immune Adherence Reaction; Immunoglobulins; Male; Meninges; Methotrexate; Microscopy, Electron; Middle Aged; Mycosis Fungoides; Neoplasms; Sheep | 1975 |
Aspects of radiation biology and radiation pathology observed during the treatment of cancer in man. The Mackenzie Davidson memorial lecture delivered at the British Institute of Radiology on May 16, 1974.
Topics: Carcinoma, Squamous Cell; Female; Humans; Lip Neoplasms; Lymphoma, Non-Hodgkin; Male; Methotrexate; Microscopy, Electron; Mitosis; Models, Biological; Mouth Neoplasms; Neoplasm Recurrence, Local; Neoplasms; Radiobiology; Radiotherapy Dosage; Tonsillar Neoplasms | 1975 |
Comparison of serum concentrations of methotrexate after various routes of administration.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Methotrexate; Middle Aged; Neoplasms; Time Factors | 1975 |
Combination chemotherapy.
Topics: Adult; Antineoplastic Agents; Child; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Fluorouracil; Humans; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Prednisone; Procarbazine; Vincristine | 1975 |
[Letter: Has Methotrexate a mutagenic effect?].
Topics: Adult; Female; Germ Cells; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Pregnancy; Psoriasis | 1976 |
Serum parathyroid hormone-related protein concentrations in patients with hematologic malignancies or solid tumors.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Doxorubicin; Female; Hematologic Diseases; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Osmolar Concentration; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Prednisolone; Proteins; Vincristine | 1992 |
Allogeneic bone marrow transplantation: the Huddinge experience.
Topics: Adult; Anemia; Bone Marrow Transplantation; Candidiasis; Child; Cyclosporine; Cytomegalovirus Infections; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Incidence; Leukemia; Male; Methotrexate; Neoplasms; Retrospective Studies; Risk Factors; Sweden; Transplantation, Homologous | 1992 |
Indomethacin and protein binding of methotrexate.
Topics: Adult; Aged; Blood Proteins; Drug Interactions; Humans; Indomethacin; Methotrexate; Middle Aged; Neoplasms; Protein Binding | 1992 |
Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate.
Topics: Aged; Carcinoma, Squamous Cell; Female; Humans; Lung Diseases, Obstructive; Male; Methotrexate; Middle Aged; Neoplasms; Pancytopenia; Pneumonia; Skin Neoplasms; Teratoma; Urinary Bladder Neoplasms | 1992 |
Protein binding of indomethacin, methotrexate and morphine in patients with cancer.
Topics: Adult; Aged; Blood Proteins; Humans; Indomethacin; Methotrexate; Middle Aged; Morphine; Neoplasms; Orosomucoid; Protein Binding; Serum Albumin | 1992 |
Pneumonia and pneumonitis in childhood malignancy.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Child; Clinical Protocols; Daunorubicin; Humans; Immunocompromised Host; Leukemia; Methotrexate; Neoplasms; Opportunistic Infections; Pneumonia; Pneumonia, Viral; Prednisolone; Prednisone; Trimethoprim, Sulfamethoxazole Drug Combination; Vincristine | 1992 |
Chemotherapy of solid tumors in private practice in Malaysia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Cyclophosphamide; Drug Administration Schedule; Epirubicin; Fluorouracil; Gastrointestinal Neoplasms; Head and Neck Neoplasms; Humans; Malaysia; Methotrexate; Mitomycin; Nasopharyngeal Neoplasms; Neoplasms; Private Practice | 1992 |
Fatal systemic candidiasis of gastrointestinal origin: an experimental model in mice compromised by anti-cancer treatment.
Topics: Animals; Candida albicans; Candidiasis; Cecum; Chemotherapy, Adjuvant; Disease Models, Animal; Esophagus; Female; Fluorouracil; Follow-Up Studies; Gastrointestinal Diseases; Immunocompromised Host; Intestines; Liver; Methotrexate; Mice; Mice, Inbred ICR; Neoplasms; Stomach; Viscera | 1992 |
Decreased incidence of graft-versus-host disease and improved survival with methotrexate combined with cyclosporin compared with monotherapy in recipients of bone marrow from donors other than HLA identical siblings.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Drug Therapy, Combination; Female; Graft vs Host Disease; HLA Antigens; Humans; Infant; Male; Methotrexate; Middle Aged; Neoplasms; Survival Rate | 1992 |
Hydrogels in endovascular embolization. V. Antitumour agent methotrexate-containing p(HEMA).
Topics: Animals; Biocompatible Materials; Blood; Embolization, Therapeutic; Femoral Artery; Gels; Hemostasis; Humans; In Vitro Techniques; Materials Testing; Methotrexate; Neoplasms; Polyhydroxyethyl Methacrylate; Rabbits | 1992 |
l-folinic acid versus d,l-folinic acid in rescue of high-dose methotrexate therapy in children.
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Female; Folic Acid; Humans; Infant; Leucovorin; Male; Methotrexate; Neoplasms; Stereoisomerism | 1992 |
Placental site trophoblastic tumor in a postmenopausal woman.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Etoposide; Female; Humans; Menopause; Methotrexate; Middle Aged; Neoplasms; Placenta Diseases; Pregnancy; Trophoblastic Neoplasms | 1991 |
Germ cell tumors in children: gonadal and extragonadal.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Child; Child, Preschool; Chorionic Gonadotropin; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Doxorubicin; Female; Humans; Infant; L-Lactate Dehydrogenase; Laparotomy; Lymph Node Excision; Male; Methotrexate; Neoplasm Staging; Neoplasms; Neoplasms, Germ Cell and Embryonal; Orchiectomy; Radiotherapy Dosage; Survival Rate; Urogenital Neoplasms; Vinblastine; Vincristine | 1991 |
[Mechanisms of resistance to methotrexate].
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cricetinae; DNA; Drug Resistance; Folate Receptors, GPI-Anchored; Gene Amplification; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Mice; Neoplasm Proteins; Neoplasms; Peptide Synthases; Phenotype; Polyglutamic Acid; Polymerase Chain Reaction; Receptors, Cell Surface; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1991 |
[Overexposure to methotrexate after high-dose therapy; salvage measures].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Humans; Leucovorin; Methotrexate; Neoplasms; Poisoning; Renal Dialysis | 1991 |
Schedule-dependent in vitro combination effects of methotrexate and 5-fluorouracil in human tumor cell lines.
Topics: Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cell Survival; Colorectal Neoplasms; Drug Administration Schedule; Fluorouracil; Humans; Lung Neoplasms; Methotrexate; Microcomputers; Molecular Conformation; Neoplasms; Software; Time Factors; Tumor Cells, Cultured | 1991 |
Interaction between methotrexate, "rescue" agents and cell proliferation as modulators of homocysteine export from cells in culture.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Homocysteine; Methotrexate; Mice; Neoplasms; Tetrahydrofolates; Thymidine | 1991 |
[Arterial infusion chemotherapy combined with biochemical modulation in cancer patients].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Fluorouracil; Humans; Immunologic Factors; Infusions, Intra-Arterial; Interferon Type I; Leucovorin; Methotrexate; Mitomycin; Mitomycins; Neoplasms | 1991 |
Antineoplastic agents inhibit the growth of Streptococcus mutans and Streptococcus sanguis in vitro.
Topics: Adult; Aged; Analysis of Variance; Doxorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Saliva; Streptococcus mutans; Streptococcus sanguis | 1991 |
Modulation of fluoropyrimidines by pretreatment with antifolates or folinic acid (leucovorin).
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasms | 1990 |
Activity measurements in human tissues of the methotrexate molecular target: a novel fluorometric assay.
Topics: Biopsy; Humans; Methotrexate; Neoplasm Proteins; Neoplasms; Organ Specificity; Spectrometry, Fluorescence; Tetrahydrofolate Dehydrogenase | 1990 |
Comparison of methods of assessment of renal function in patients with cancer treated with cisplatin, carboplatin or methotrexate.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Creatinine; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Function Tests; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Neoplasms; Technetium Tc 99m Pentetate | 1990 |
Nutritional deficiencies in patients receiving cancer chemotherapy.
Topics: Antineoplastic Agents; Cachexia; Folic Acid Deficiency; Humans; Hypoproteinemia; Methotrexate; Neoplasms; Niacin; Nutrition Disorders; Nutritional Status; Pellagra; Riboflavin Deficiency; Thymine; Vitamin B Deficiency; Vitamin K Deficiency | 1990 |
[Enhancing factors in the cardiotoxicity of anthracyclines].
Topics: Antibiotics, Antineoplastic; Cardiomyopathies; Child; Cyclophosphamide; Doxorubicin; Drug Synergism; Echocardiography; Heart; Humans; Melphalan; Methotrexate; Neoplasms | 1990 |
Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine | 1990 |
[Combination of radiation and drug therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cisplatin; Combined Modality Therapy; Head and Neck Neoplasms; Humans; Lung Neoplasms; Methotrexate; Neoplasms; Vincristine | 1987 |
Is ectopic production of human chorionic gonadotrophin (hCG) or alpha fetoprotein (AFP) by tumours a marker of chemosensitivity?
Topics: alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chorionic Gonadotropin; Cisplatin; Dactinomycin; Doxorubicin; Etoposide; Hormones, Ectopic; Humans; Leucovorin; Methotrexate; Neoplasms; Vincristine | 1986 |
Methotrexate (MTX) concentration in tumors following low-dose MTX.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Methotrexate; Neoplasms; Polyglutamic Acid; Radioligand Assay | 1987 |
Peplomycin and liblomycin, a new analogues of bleomycin.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dogs; Humans; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Peplomycin; Rats; Vincristine | 1987 |
Kinetics of methotrexate and its metabolites in red blood cells.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Erythrocytes; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Polyglutamic Acid; Time Factors | 1987 |
Biochemical and pharmacologic rationale for high-dose methotrexate.
Topics: Biological Transport; Biotransformation; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Folic Acid; Humans; Leucovorin; Methotrexate; Neoplasms; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1987 |
Effect of various oxygenation conditions and fluosol-DA on cancer chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Bleomycin; Breast Neoplasms; Carbon Dioxide; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Combinations; Fibrosarcoma; Fluorocarbons; Fluorouracil; Humans; Hydroxyethyl Starch Derivatives; Male; Melphalan; Methotrexate; Mice; Mice, Inbred C3H; Mice, Nude; Neoplasm Transplantation; Neoplasms; Organoplatinum Compounds; Oxygen; Tumor Cells, Cultured | 1988 |
Recombinant human granulocyte colony stimulating factors: therapeutic application in the prevention of chemotherapy-induced neutropenia.
Topics: Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Colony-Stimulating Factors; Doxorubicin; Drug Evaluation; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Neoplasms; Neutropenia; Neutrophils; Recombinant Proteins; Vinblastine | 1988 |
[Arterial infusion method: its theory and clinical application--dosage and regimen].
Topics: Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Administration Schedule; Fluorouracil; Humans; Infusions, Intra-Arterial; Methotrexate; Mitomycin; Mitomycins; Neoplasms | 1985 |
The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Fluorouracil; Humans; Methotrexate; Neoplasms; Ornithine Decarboxylase; Orotate Phosphoribosyltransferase; Pentosephosphates; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1985 |
[Various doses cisplatin combined with multi-drug chemotherapy of malignant solid tumors].
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Squamous Cell; Cisplatin; Female; Fluorouracil; Humans; Lomustine; Lung Neoplasms; Male; Melanoma; Melphalan; Methotrexate; Middle Aged; Neoplasms; Procarbazine; Testicular Neoplasms; Vincristine | 1989 |
Resistance to methotrexate and multidrug resistance in childhood malignancies.
Topics: Adolescent; Adult; Antineoplastic Agents; Burkitt Lymphoma; Child; DNA, Neoplasm; Drug Resistance; Female; Humans; Infant; Leukemia; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma; RNA, Neoplasm; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1989 |
The basis for intrinsic drug resistance or sensitivity to methotrexate.
Topics: Carcinoma, Squamous Cell; Drug Resistance; Head and Neck Neoplasms; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Soft Tissue Neoplasms; Tumor Cells, Cultured | 1989 |
Pharmacokinetics of platinum in cancer patients treated with carboplatin in combination with high-dose methotrexate.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Creatinine; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Organoplatinum Compounds; Platinum; Spectrophotometry, Atomic; Ultrafiltration | 1989 |
[Combination chemotherapy of CPM-MTX-5-FU in non-resectable and recurrent cancer patients].
Topics: Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Administration Schedule; Drug Evaluation; Fatigue; Fluorouracil; Humans; Leukopenia; Methotrexate; Nausea; Neoplasm Recurrence, Local; Neoplasms; Remission Induction; Stomach Neoplasms | 1989 |
Methotrexate toxicity coincident with packed red cell transfusions.
Topics: Erythrocyte Transfusion; Humans; Methotrexate; Neoplasms; Transfusion Reaction | 1986 |
Cyclophosphamide, methotrexate, and 5-fluorouracil in a three-drug admixture. Phase I trial of 14-day continuous ambulatory infusion.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Administration Schedule; Drug Combinations; Drug Evaluation; Drug Stability; Fluorouracil; Humans; Infusions, Intravenous; Leukopenia; Methotrexate; Neoplasms; Thrombocytopenia | 1989 |
Methotrexate and dipyridamole combination chemotherapy based upon inhibition of nucleoside salvage in humans.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dipyridamole; Humans; Methotrexate; Neoplasms; Nucleosides | 1989 |
DNA lesions in human neoplastic cells and cytotoxicity of 5-fluoropyrimidines.
Topics: Aphidicolin; Cell Survival; Centrifugation, Density Gradient; Diterpenes; DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; Methotrexate; Neoplasms; Time Factors | 1986 |
Enhancement of the effects of 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Drug Synergism; Floxuridine; Fluorouracil; Humans; Methotrexate; Neoplasms; Pyrimidines | 1986 |
Acute effects of various chemotherapeutic combinations on hypophyseal and pineal hormone secretions in cancer patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; beta-Endorphin; Cisplatin; Cyclophosphamide; Doxorubicin; Endorphins; Epirubicin; Female; Fluorouracil; Humans; Hydrocortisone; Male; Melatonin; Methotrexate; Neoplasms; Pineal Gland; Pituitary Gland, Anterior; Pituitary Hormones, Anterior; Secretory Rate; Vincristine | 1987 |
Studies of methotrexate-monoclonal antibody conjugates for immunotherapy.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cell Line; Cell Transformation, Viral; Colonic Neoplasms; Cytotoxicity Tests, Immunologic; Esterification; Herpesvirus 4, Human; Humans; Immunotherapy; Leukemia, Lymphoid; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms; Receptors, Cell Surface; Receptors, Transferrin; Rosette Formation | 1985 |
Metabolites of 5-fluorouracil in plasma and urine, as monitored by 19F nuclear magnetic resonance spectroscopy, for patients receiving chemotherapy with or without methotrexate pretreatment.
Topics: Aged; beta-Alanine; Blood Proteins; Chromatography, High Pressure Liquid; Female; Fluorides; Fluorouracil; Humans; Kinetics; Magnetic Resonance Spectroscopy; Male; Methotrexate; Middle Aged; Neoplasms; Protein Binding | 1988 |
42-hour methotrexate infusions as relapse therapy for childhood malignancies: toxicity and efficacy of 109 infusions.
Topics: Adolescent; Adult; Child; Child, Preschool; Combined Modality Therapy; Drug Evaluation; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Neoplasm Recurrence, Local; Neoplasms | 1987 |
Action of intermediate doses of methotrexate on dihydrofolate reductase in malignant diseases.
Topics: Brain Neoplasms; Child; Folic Acid Antagonists; Humans; Leukocytes; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Proteins; Neoplasms; Sarcoma; Tetrahydrofolate Dehydrogenase | 1987 |
Lactoferrin and C-reactive protein in response to cytostatic drugs with emphasis on methotrexate.
Topics: Adult; Antineoplastic Agents; Biomarkers; C-Reactive Protein; Child; Enzyme-Linked Immunosorbent Assay; Humans; Lactoferrin; Methotrexate; Neoplasms; Neutrophils | 1987 |
[Secondary effects of adjuvant therapy].
Topics: Alopecia; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Cystitis; Doxorubicin; Drug Eruptions; Female; Fluorouracil; Heart; Humans; Methotrexate; Mitolactol; Mitomycins; Neoplasms | 1985 |
[Increased secretion of vasopressin and edema formation in high dosage methotrexate therapy].
Topics: Arginine Vasopressin; Dose-Response Relationship, Drug; Edema; Humans; Inappropriate ADH Syndrome; Methotrexate; Neoplasms; Water-Electrolyte Balance | 1988 |
Clinical and pharmacologic reappraisal of dichloromethotrexate.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Dose-Response Relationship, Drug; Female; Humans; Liver; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Neoplasms | 1988 |
Induction of lymphokine-activated killer-like cells by cancer chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytotoxicity Tests, Immunologic; Doxorubicin; Humans; Methotrexate; Neoplasms; Vinblastine | 1988 |
Childhood cancers' improved survival rates can exact a price in late effects of therapy.
Topics: Child; Humans; Methotrexate; Neoplasms; Neoplasms, Radiation-Induced; Preventive Medicine; Prostheses and Implants; Time Factors; Transplantation, Homologous | 1988 |
[High-dose methotrexate with citrovorum factor rescue (HD-MTX-CFR) in the treatment of malignant solid tumors--clinical analysis of 62 patients].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Follow-Up Studies; Humans; Leucovorin; Lung Neoplasms; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms; Osteosarcoma | 1988 |
[Enzyme immunoassay for the determination of methotrexate in serum].
Topics: Dose-Response Relationship, Drug; Humans; Immunoenzyme Techniques; Methotrexate; Neoplasms | 1988 |
Anti-neoplastic synergism of nitrous oxide and methotrexate.
Topics: Drug Synergism; Humans; Methotrexate; Neoplasms; Nitrous Oxide | 1988 |
Pharmacokinetics of high and moderate intravenous doses of methotrexate.
Topics: Adolescent; Adult; Aged; Half-Life; Humans; Injections, Intravenous; Methotrexate; Middle Aged; Models, Biological; Neoplasms | 1988 |
High dose methotrexate therapy: insecure rationale?
Topics: Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Thymidylate Synthase | 1988 |
On the role of folate deficiency in cancer therapy.
Topics: Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Neoplasms | 1988 |
Cerebellar sclerosis in pediatric cancer patients.
Topics: Cerebellum; Child; Child, Preschool; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasms; Neuroblastoma; Osteosarcoma; Retrospective Studies; Sclerosis | 1987 |
Methodology for the rational development of methotrexate analogs in the clinic.
Topics: Antibiotics, Antineoplastic; Drug Evaluation; Folic Acid Antagonists; Humans; Methotrexate; Naphthacenes; Neoplasms; Platinum | 1987 |
Methotrexate therapy and nitrous oxide anesthesia.
Topics: Anesthesia, General; Child; Child, Preschool; Drug Interactions; Humans; Leucovorin; Methotrexate; Neoplasms; Nitrous Oxide | 1986 |
An investigation into the source of the deglutamated metabolites of methotrexate in patients treated with high dose infusions.
Topics: Biotransformation; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Leucovorin; Liver; Methotrexate; Microbial Sensitivity Tests; Neoplasms; Oxidation-Reduction | 1986 |
Plasma kinetic study of folinic acid and 5-methyltetrahydrofolate in healthy volunteers and cancer patients by high-performance liquid chromatography.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Kinetics; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Tetrahydrofolates | 1987 |
Biodistribution of methotrexate-monoclonal antibody conjugates and complexes: experimental and clinical studies.
Topics: Animals; Antibodies, Monoclonal; Humans; Immunotoxins; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Tissue Distribution | 1987 |
Pharmacokinetics of methotrexate in Indian children and its relationship to nutritional status.
Topics: Adolescent; Anthropometry; Blood Proteins; Child; Child, Preschool; Female; Humans; India; Infant; Kinetics; Male; Methotrexate; Neoplasms; Nutritional Status | 1987 |
Activation of haemostasis by combined chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Hemostasis; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Neoplasms; Prednisone; Vincristine | 1987 |
[Effect of methotrexate on 5-fluorouracil metabolism and clinical studies with methotrexate and 5-fluorouracil sequential therapy].
Topics: Drug Administration Schedule; Drug Synergism; Fluorouracil; Humans; Methotrexate; Neoplasms | 1986 |
Cross-sensitivity of methylating agents, hydroxyurea, and methotrexate in human tumor cells of the Mer- phenotype.
Topics: Adenoviridae; Alkylating Agents; Cell Line; Cell Survival; Dacarbazine; Drug Resistance; Humans; Hydroxyurea; Methotrexate; Methyltransferases; Neoplasms; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Virus Replication | 1986 |
Pharmacokinetics of methotrexate and its 7-OH metabolite in cancer patients treated with different high-methotrexate dosage regimens.
Topics: Adolescent; Adult; Child; Drug Administration Schedule; Female; Humans; Kinetics; Male; Methotrexate; Middle Aged; Neoplasms | 1986 |
Methotrexate resistance in murine and human continuous tumour cell lines: an examination of the different mechanisms involved depending on the order of resistance expressed.
Topics: Animals; Cell Line; Drug Resistance; Gene Amplification; Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 1986 |
[Results of a pilot study of hyaluronidase as an adjunct to cytostatic therapy in malignant diseases].
Topics: Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Tolerance; Female; Humans; Hyaluronoglucosaminidase; Lomustine; Male; Mechlorethamine; Methotrexate; Neoplasms; Peptichemio; Pilot Projects; Prednisone; Procarbazine; Vincristine | 1985 |
[Drug administration in combination for management of cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubicin; Drug Administration Schedule; Drug Synergism; Fluorouracil; Humans; Mercaptopurine; Methotrexate; Neoplasms; Nimustine; Nitrosourea Compounds | 1985 |
Management of cancer in the elderly. Implications of the aging process.
Topics: Aged; Aging; Colonic Neoplasms; Doxorubicin; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms; Rectal Neoplasms; Semustine; Socioeconomic Factors; Uterine Cervical Neoplasms | 1985 |
[High-dose treatment].
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Daunorubicin; Doxorubicin; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Humans; Infusions, Parenteral; Leucovorin; Leukemia; Methotrexate; Neoplasms | 1985 |
[Clinical significance of non-renal elimination mechanisms of methotrexate (MTX)].
Topics: Abdominal Neoplasms; Adolescent; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bile; Child; Child, Preschool; Cholestyramine Resin; Chromatography, High Pressure Liquid; Enterohepatic Circulation; Female; Femoral Neoplasms; Humans; Kinetics; Lymphoma; Male; Metabolic Clearance Rate; Methotrexate; Neoplasms; Osteosarcoma | 1985 |
Reduced citrovorum factor rescue for high-dose methotrexate therapy in childhood malignancies.
Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Bone Marrow; Child; Child, Preschool; Drug Therapy, Combination; Female; Folic Acid; Humans; Infusions, Parenteral; Leucovorin; Leukocyte Count; Male; Methotrexate; Neoplasms; Time Factors | 1985 |
Neurologic complications of bone marrow transplantation.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Brain Diseases, Metabolic; Central Nervous System; Central Nervous System Diseases; Cerebrovascular Disorders; Child; Child, Preschool; Female; Graft vs Host Disease; Humans; Infections; Leukemia; Male; Methotrexate; Middle Aged; Necrosis; Neoplasms; Postoperative Complications; Seizures; Spinal Cord Diseases | 1985 |
A new form of dihydrofolate reductase in cancer cells.
Topics: Animals; Cells, Cultured; Chromatography, Gel; Clinical Enzyme Tests; Humans; Methotrexate; Mice; Neoplasms; Radioligand Assay; Tetrahydrofolate Dehydrogenase | 1985 |
Mechanisms of resistance to methotrexate.
Topics: Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms | 1985 |
Incidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimens.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Cystitis; Humans; Immunosuppressive Agents; Leukemia; Lymphoma; Methotrexate; Neoplasms; Risk; Time Factors; Urinary Bladder Neoplasms | 1985 |
Selective toxicity of a new lipophilic antifolate, BW301U, for methotrexate-resistant cells with reduced drug uptake.
Topics: Antineoplastic Agents; Cell Line; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Pyrimethamine; Pyrimidines | 1985 |
Fifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneity.
Topics: Animals; Cells, Cultured; Chromosome Aberrations; DNA; DNA Replication; Drug Resistance; Gene Amplification; Humans; Hydroxyurea; Methotrexate; Mice; Neoplasms; Tetrahydrofolate Dehydrogenase | 1985 |
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay | 1985 |
[Biochemical modulation in cancer chemotherapy].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Synergism; Fluorouracil; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms; Nucleosides; Pyrimidine Nucleosides | 1985 |
Sequential infusions of methotrexate and 5-fluorouracil in advanced cancer: pharmacology, toxicity, and response.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Half-Life; Humans; Male; Methotrexate; Middle Aged; Neoplasms | 1985 |
Dichloromethotrexate--a critical reassessment.
Topics: Animals; Antineoplastic Agents; Drug Evaluation; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Infusions, Intra-Arterial; Kinetics; Methotrexate; Neoplasms; Neoplasms, Experimental | 1985 |
A phase I and pharmacology study of continuous-infusion low-dose methotrexate administration.
Topics: Adult; Aged; Drug Evaluation; Humans; Infusions, Parenteral; Kinetics; Methotrexate; Middle Aged; Neoplasms; Stomatitis; Thrombocytopenia | 1985 |
5-Fluorouracil and methotrexate administered simultaneously as a continuous infusion. A phase I study.
Topics: Adult; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Infusions, Parenteral; Male; Methotrexate; Middle Aged; Neoplasms; Stomatitis; Thrombocytopenia | 1985 |
Comparison of linear and tapered intravenous infusion of methotrexate in oncochemotherapy. A theoretical approach.
Topics: Humans; Infusions, Parenteral; Kinetics; Male; Methotrexate; Middle Aged; Models, Biological; Neoplasms; Statistics as Topic | 1985 |
Lack of dihydrofolate reductase in human tumor and leukemia cells in vivo.
Topics: Animals; Cattle; Cell Line; Cells, Cultured; Chickens; Humans; Leukemia, Experimental; Liver; Methotrexate; NADP; Neoplasms; Tetrahydrofolate Dehydrogenase; Tissue Distribution | 1985 |
Dosage predictions in high-dose methotrexate infusions. Part 2: Bayesian estimation of methotrexate clearance.
Topics: Humans; Kinetics; Mathematics; Metabolic Clearance Rate; Methotrexate; Models, Biological; Neoplasms; Time Factors | 1985 |
[The children of mothers treated with immunosuppressive drugs].
Topics: Adult; Bilirubin; Blood Group Incompatibility; Blood Proteins; Female; Fetus; gamma-Globulins; Humans; Immunoglobulins; Immunosuppressive Agents; Infant, Newborn; Infant, Premature; Mercaptopurine; Methotrexate; Neoplasms; Pregnancy; Pregnancy Complications; Rh-Hr Blood-Group System; Umbilical Cord | 1970 |
Chemotherapy in head and neck cancer.
Topics: Administration, Oral; Antineoplastic Agents; Arteries; Carcinoma, Squamous Cell; Head; Head and Neck Neoplasms; Humans; Hydroxyurea; Infusions, Parenteral; Injections, Intravenous; Methotrexate; Neoplasm Metastasis; Neoplasms; Palliative Care; Remission, Spontaneous; Time Factors | 1971 |
[Chemotherapy of so-called solid tumors].
Topics: Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Drug Synergism; Fluorouracil; Humans; Immunosuppressive Agents; Methotrexate; Neoplasms; Palliative Care; Prognosis; Thiotepa; Vinblastine | 1971 |
[Chemotherapy by intra-arterial path in cancer of the "head and neck" region].
Topics: Antineoplastic Agents; Bleomycin; Facial Neoplasms; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Laryngeal Neoplasms; Lip Neoplasms; Maxillary Neoplasms; Methotrexate; Mouth Neoplasms; Neoplasms; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Salivary Gland Neoplasms; Thyroid Neoplasms; Tongue Neoplasms | 1971 |
Factors influencing the success of arterial infusion chemotherapy for cancer of the head and neck.
Topics: Age Factors; Aged; Antineoplastic Agents; Bleomycin; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cystadenoma; Drug Synergism; Eye Neoplasms; Female; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Laryngeal Neoplasms; Male; Mechlorethamine; Methotrexate; Middle Aged; Mouth Neoplasms; Neoplasms; Pharyngeal Neoplasms; Remission, Spontaneous; Skin Neoplasms | 1972 |
[Therapy of leukemic and sarcomatous meningopathies in the adult age].
Topics: Adult; Central Nervous System Diseases; Chemical Phenomena; Chemistry; Humans; Injections, Spinal; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Meninges; Methotrexate; Neoplasms | 1972 |
[Mitomycin alone and in therapeutic association in the palliative treatment of solid tumors].
Topics: Antineoplastic Agents; Breast Neoplasms; Cobalt Isotopes; Cyclophosphamide; Drug Combinations; Female; Fluorouracil; Humans; Intestinal Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Melanoma; Methotrexate; Mitomycins; Neoplasms; Palliative Care; Pharyngeal Neoplasms; Sarcoma; Thiotepa; Tongue Neoplasms; Urogenital Neoplasms; Vinblastine | 1971 |
[The best chemotherapy in the world can only give what it can].
Topics: Antineoplastic Agents; Asparaginase; Drug Combinations; Drug Interactions; Humans; Leukemia, Lymphoid; Methotrexate; Neoplasms; Palliative Care; Prognosis | 1972 |
Value of cytotoxic infusion in dyspnoea and dysphagia due to cancer.
Topics: Antineoplastic Agents; Cyclophosphamide; Deglutition Disorders; Dyspnea; Esophageal Neoplasms; Fluorouracil; Humans; Infusions, Parenteral; Laryngeal Neoplasms; Methotrexate; Neoplasms; Pharyngeal Neoplasms | 1973 |
Bleomycin--a new approach in cancer chemotherapy.
Topics: Adult; Aged; Alopecia; Antibiotics, Antineoplastic; Bleomycin; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Ear Neoplasms; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Male; Mandibular Neoplasms; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasms; Nose Neoplasms; Penile Neoplasms; Pulmonary Fibrosis; Remission, Spontaneous; Skin Neoplasms | 1973 |
[A 3-drug combination in the palliative treatment of cancer. Analysis of a series of 146 cases].
Topics: Adult; Aged; Cyclophosphamide; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Palliative Care; Remission, Spontaneous; Vinblastine | 1973 |
Chemotherapeutic response of epithelial tumors produced by primary implantation of a nonproducer line of murine sarcoma virus-transformed BALB 3T3 cells.
Topics: Animals; Bleomycin; Cyclophosphamide; Female; Fluorouracil; Male; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms; Nitrosourea Compounds; Sarcoma, Experimental; Time Factors; Transplantation, Homologous | 1973 |
[Results with the cytostatic agent bleomycin in tumour therapy (author's transl)].
Topics: Adult; Aged; Bleomycin; Bronchial Neoplasms; Carcinoma, Squamous Cell; Chlorambucil; Doxorubicin; Drug Evaluation; Drug Therapy, Combination; Dysgerminoma; Female; Hodgkin Disease; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Neoplasms; Neurilemmoma; Pulmonary Fibrosis; Remission, Spontaneous; Vinblastine | 1973 |
[Selective tumour chemotherapy using oncobiograms (author's transl)].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cricetinae; Culture Techniques; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation; Drug Resistance; Fluorouracil; Humans; Methods; Methotrexate; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Procarbazine; Radioisotopes; Rats; Scintillation Counting; Thymidine; Triaziquone; Uridine | 1974 |
Intra-arterial infusion chemotherapy in head and neck cancer. A clinical and experimental study.
Topics: Animals; Carotid Artery, External; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Disease Models, Animal; Drug Therapy, Combination; Fluorouracil; Follow-Up Studies; Head; Head and Neck Neoplasms; Humans; Methods; Methotrexate; Neoplasms; Rats; Rhabdomyosarcoma; Staining and Labeling | 1973 |
Chemotherapy in recurrent heat and neck cancer.
Topics: Antineoplastic Agents; Bleomycin; Carcinoma, Squamous Cell; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Hydroxyurea; Injections, Intra-Arterial; Injections, Intramuscular; Methotrexate; Neoplasm Recurrence, Local; Neoplasms; Vinblastine; Vincristine | 1974 |
Intensive cytotoxic chemotherapy.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Division; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Drug Resistance; Drug Therapy, Combination; Female; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Methotrexate; Mice; Mitosis; Neoplasm Metastasis; Neoplasms; Pregnancy; Trophoblastic Neoplasms; Vinblastine | 1971 |
Antibodies as carriers of anticancer agents.
Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Reactions; Antigens, Neoplasm; Antineoplastic Agents; Boron; Carcinoma, Ehrlich Tumor; Chlorambucil; Cricetinae; Cytotoxicity Tests, Immunologic; Diphtheria Toxin; Glucose Oxidase; Immune Sera; Immunotherapy; Iodine Radioisotopes; Leukemia L1210; Lymphoma; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Rabbits | 1974 |
[The influence of chemotherapy on delayed allergy in patients with malignant tumors].
Topics: Antigens; Antineoplastic Agents; Benzene Derivatives; Bleomycin; Breast Diseases; Breast Neoplasms; Cyclophosphamide; Drug Combinations; Female; Fluorobenzenes; Hodgkin Disease; Humans; Hydrazones; Hypersensitivity, Delayed; Immune System Diseases; Immunity, Cellular; Leukemia; Lung Neoplasms; Methotrexate; Multiple Myeloma; Neoplasms; Nitrobenzenes; Olivomycins; Skin; Stomach Neoplasms; Triaziquone; Tuberculin; Vinblastine | 1973 |
Influence of cytostatics on aggregation and adenine nucleotides of platelets.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Amidines; Antineoplastic Agents; Aspirin; Bleomycin; Blood Platelets; Cell Membrane; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Glyoxal; Humans; Hydrazones; Methotrexate; Neoplasms; Platelet Adhesiveness; Triaziquone; Vinca Alkaloids | 1972 |
[The effects of cytostatic agents on short-term cultures (3H-uridine incorporation) and tissue cultures (cell counts) from human tumors (author's transl)].
Topics: Antineoplastic Agents; Bleomycin; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; In Vitro Techniques; Methods; Methotrexate; Neoplasms; Ovarian Neoplasms; Podophyllin; Suspensions; Time Factors; Triaziquone; Tritium; Uridine | 1974 |
Editorial: Drug targets in cancer chemotherapy.
Topics: Antineoplastic Agents; Dactinomycin; Doxorubicin; Enzyme Inhibitors; Fluorouracil; Isoenzymes; Methotrexate; Neoplasms; Rifampin | 1974 |
[The effect of cytostatic drugs on blood platelets and lymphocytes in patients with neoplasms].
Topics: Adenine Nucleotides; Adenosine Diphosphate; Amidines; Antibiotics, Antineoplastic; Bleomycin; Blood Platelets; Breast Neoplasms; Bronchial Neoplasms; Cyclophosphamide; Doxorubicin; Firefly Luciferin; Fluorouracil; Glyoxal; Hodgkin Disease; Humans; Hydrazones; Leukemia; Luciferases; Lymphocytes; Melphalan; Methotrexate; Neoplasms; Nephelometry and Turbidimetry; Plasmacytoma; Platelet Aggregation; Vinca Alkaloids | 1974 |
[Arterial chemotherapy infusions of long duration in the treatment of cancer. Place and limitations of this method].
Topics: Adult; Aged; Female; Humans; Injections, Intra-Arterial; Lymphatic Metastasis; Male; Methotrexate; Neoplasms; Palliative Care; Paranasal Sinus Neoplasms | 1965 |
Effects of antitumor agents and hyperbaric oxygen in normal and tumor-bearing rodents.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Hyperbaric Oxygenation; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Mitomycins; Neoplasms; Nitrogen Mustard Compounds; Rats; Thiotepa | 1966 |
Microscopy of the cancer cell as a guide to cancer chemotherapy.
Topics: Adult; Aged; Blood Cell Count; Blood Platelets; Cell Nucleus; Female; Humans; Male; Mercaptopurine; Methotrexate; Microscopy; Middle Aged; Neoplasms | 1967 |
[On the question of preclinical selection of cytostatics in the area of treatment of human tumors].
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Culture Techniques; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Humans; Lung Neoplasms; Methods; Methotrexate; Neoplasms; Neoplasms, Experimental; Radionuclide Imaging; Rats; RNA, Neoplasm; Stimulation, Chemical; Thymidine; Triaziquone; Tritium; Vinblastine; Vincristine | 1969 |
Treatment of advanced cancer with active immunization.
Topics: Animals; Antibiotics, Antineoplastic; Antibodies; Antigen-Antibody Reactions; Breast Neoplasms; Colonic Neoplasms; gamma-Globulins; Humans; Hypersensitivity; Immunotherapy; Melanoma; Methotrexate; Neoplasms; Rabbits; Rhabdomyosarcoma; Sarcoma; Stomach Neoplasms | 1969 |
[Treatment of inoperable tumors by continuous and prolonged arterial perfusion of an antimitotic association].
Topics: Antineoplastic Agents; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Floxuridine; Fluorouracil; Humans; Methotrexate; Mitomycins; Neoplasms; Palliative Care; Perfusion; Vinblastine; Vincristine | 1969 |
[Chemotherapy of solid tumors with a combination of low doses of vincristine and high doses of methotrexate].
Topics: Drug Synergism; Humans; Methotrexate; Neoplasms; Palliative Care; Vincristine | 1969 |
Effect of chemotherapeutic agents upon microorganisms isolated from cancer patients.
Topics: Antineoplastic Agents; Cyclophosphamide; Cytarabine; Escherichia coli; Humans; Klebsiella pneumoniae; Methotrexate; Neoplasms; Proteus; Pseudomonas aeruginosa; Serratia marcescens | 1972 |
[Chromosomal studies in correlation with other biologic constants in neoplasms treated by chemotherapy].
Topics: Adult; Antibody Formation; Bone Marrow; Cell Division; Chromosome Aberrations; Female; Fluorouracil; Humans; Immunity, Cellular; Male; Melphalan; Methotrexate; Middle Aged; Mitosis; Neoplasms; Thiotepa | 1974 |
Pharmacodynamic and pharmacokinetic measurements of antitumor agents.
Topics: Animals; Antineoplastic Agents; Body Surface Area; Cell Division; Cricetinae; Culture Techniques; Cyclophosphamide; Cytarabine; Dogs; Half-Life; Haplorhini; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid; Methotrexate; Mice; Mice, Inbred Strains; Neoplasms; Rats; Species Specificity; Time Factors | 1974 |
Responses of freshly cultured tumour cells to certain selected chemotherapeutic agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Chlorambucil; Colchicine; Culture Techniques; Cyclophosphamide; Dactinomycin; Female; Floxuridine; Fluorouracil; Hodgkin Disease; Humans; Melphalan; Mercaptopurine; Methotrexate; Nandrolone; Neoplasms; Nitrogen Mustard Compounds; Norethindrone; Prednisolone; Progesterone; Testosterone; Thiotepa; Uterine Neoplasms; Vinblastine | 1968 |
[Chemotherapy of cancers in the O.R.L. sphere].
Topics: Antineoplastic Agents; Humans; Methotrexate; Neoplasms; Otorhinolaryngologic Diseases; Prognosis | 1970 |
The variability of individual tolerance to methotrexate in cancer patients.
Topics: Adult; Age Factors; Aged; Alopecia; Blood Urea Nitrogen; Body Weight; Chemical and Drug Induced Liver Injury; Conjunctivitis; Creatinine; Diarrhea; Drug Eruptions; Folic Acid; Humans; Injections, Intravenous; Leukopenia; Methotrexate; Middle Aged; Nausea; Neoplasms; Serum Albumin; Stomatitis; Thrombocytopenia; Time Factors; Vomiting | 1971 |
Regional arterial chemotherapy for advanced carcinoma of the head and neck. A ten-year review.
Topics: Antimetabolites; Antineoplastic Agents; Carotid Arteries; Catheterization; Digestive System; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Methotrexate; Neoplasms; Remission, Spontaneous | 1973 |
Combination cancer chemotherapy--a clinical trial on outpatients.
Topics: Adolescent; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasms | 1974 |
Effectiveness of high-dose infusions of methotrexate followed by leucovorin in carcinoma of the head and neck.
Topics: Adenocarcinoma, Mucinous; Adult; Aged; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Jaw Neoplasms; Laryngeal Neoplasms; Leucovorin; Leukopenia; Male; Methotrexate; Middle Aged; Mouth Neoplasms; Neoplasm Metastasis; Neoplasms; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Salivary Glands; Thrombocytopenia; Tongue Neoplasms; Tonsillar Neoplasms | 1968 |
[Therapy of malignant tumors in childhood].
Topics: Adrenocorticotropic Hormone; Antineoplastic Agents; Child, Preschool; Eosinophilic Granuloma; Histiocytosis, Langerhans-Cell; Humans; Leukemia; Methotrexate; Neoplasms; Neuroblastoma; Prednisone; Sarcoma, Ewing; Vincristine; Wilms Tumor | 1969 |
Transplacental chemical carcinogenesis in man.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Chloramphenicol; Diethylstilbestrol; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Maternal-Fetal Exchange; Methotrexate; Mice; Neoplasms; Neoplasms, Muscle Tissue; Phenytoin; Pregnancy; Uterine Cervical Neoplasms; Vaginal Neoplasms | 1971 |
[Combined antineoplastic agents and surgery in treatment of cancer with multiple localizations: 22 cases].
Topics: Antineoplastic Agents; Cyclophosphamide; Drug Synergism; Female; Fluorouracil; Humans; Male; Methods; Methotrexate; Neoplasm Metastasis; Neoplasms; Prognosis; Vinblastine | 1970 |
Blood and neoplastic diseases. Solid tumours in children.
Topics: Adolescent; Biopsy; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Diagnosis, Differential; Doxorubicin; Hodgkin Disease; Humans; Infant; Methods; Methotrexate; Neoplasms; Neuroblastoma; Nitrogen Mustard Compounds; Osteosarcoma; Prednisolone; Prognosis; Radiography; Retinoblastoma; Rhabdomyosarcoma; Sarcoma, Ewing; Vincristine; Wilms Tumor | 1974 |
"Induction" of dihydrofolate reductase: purification and properties of the "induced" human erythrocyte and leukocyte enzyme and normal bone marrow enzyme.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromatography; Enzyme Activation; Enzyme Induction; Erythrocytes; Folic Acid; Humans; Hydrogen-Ion Concentration; Immune Sera; Leukemia L1210; Leukocytes; Methotrexate; Molecular Weight; NAD; NADP; Neoplasms; Protein Denaturation; Tetrahydrofolate Dehydrogenase | 1970 |
Effect of route of administration and effusions on methotrexate pharmacokinetics.
Topics: Administration, Oral; Ascitic Fluid; Female; Half-Life; Humans; Injections, Intravenous; Kinetics; Male; Methotrexate; Neoplasm Metastasis; Neoplasms; Peritoneal Neoplasms; Pleural Effusion; Protein Binding; Tritium | 1974 |
[Neurotoxicity of some antineoplastic agents].
Topics: Antineoplastic Agents; Child; Child, Preschool; Doxorubicin; Facial Paralysis; Humans; Infant; Leukemia; Lymphoma; Methotrexate; Motor Neurons; Myasthenia Gravis; Neoplasms; Nervous System; Nervous System Diseases; Paresthesia; Seizures; Vinblastine; Vincristine | 1974 |
In vitro estimate of sensitivity of individual human tumors to antitumor agents.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Arsenicals; Benzoates; Breast Neoplasms; Carbon Radioisotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Cattle; Depression, Chemical; DNA, Neoplasm; Female; Fluorouracil; Humans; In Vitro Techniques; Iodoacetates; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Lymphoma, Non-Hodgkin; Mechlorethamine; Methotrexate; Mice; Neoplasms; Phenylalanine; Succinate Dehydrogenase; Thymidine; Tritium | 1974 |
An immunological approach to the treatment of malignant disease.
Topics: Child; Humans; Immunotherapy; Leukemia, Lymphoid; Methotrexate; Neoplasms | 1973 |
[A new approach to chemotherapeutic combinations in the treatment of solid tumors: trail synchronization, recruitement].
Topics: Antineoplastic Agents; Cyclophosphamide; Cytarabine; Doxorubicin; Humans; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Methotrexate; Mitosis; Neoplasms; Vincristine | 1973 |
Blood and neoplastic diseases. Rational approach to the chemotherapy of human malignant disease-II.
Topics: Antineoplastic Agents; Brain Neoplasms; Busulfan; Cell Count; Cell Division; Cytarabine; Diffusion; Drug Tolerance; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocyte Count; Lymphoma; Methotrexate; Multiple Myeloma; Neoplasms; Vincristine | 1974 |
Cancer chemotherapy: mechanisms of action.
Topics: Alkaloids; Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Binding Sites; Cytarabine; Drug Synergism; Enzyme Therapy; Folic Acid Antagonists; Humans; Hydroxyurea; Leucovorin; Mechlorethamine; Mercaptopurine; Methotrexate; Mitomycins; Neoplasms; Nucleic Acids; Purines; Pyrimidines; Steroids; Thioguanine; Vinblastine; Vincristine | 1973 |
Combination of methotrexate and external irradiation in advanced cancer patients.
Topics: Adult; Aged; Blood Cells; Cobalt Radioisotopes; Humans; Leucovorin; Methotrexate; Middle Aged; Mouth; Neoplasms; Radioisotope Teletherapy | 1974 |
Clinical trials and pharmacokinetics of intermittent high-dose methotrexate-"leucovorin rescue" for children with malignant tumors.
Topics: Adolescent; Age Factors; Aspartate Aminotransferases; Child; Child, Preschool; Female; Half-Life; Hematopoiesis; Humans; Kidney; Leucovorin; Liposarcoma; Methotrexate; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Ovarian Neoplasms; Rhabdomyosarcoma; Sarcoma, Ewing; Teratoma | 1974 |
Radioimmunoassay for methotrexate.
Topics: Animals; Antibody Specificity; Antigen-Antibody Complex; Dialysis; Goats; Hemocyanins; Humans; Leucovorin; Methotrexate; Neoplasms; Rabbits; Radioimmunoassay; Time Factors; Tritium | 1974 |
Polymyositis and dermatomyositis.
Topics: Biopsy; Dermatomyositis; Female; Humans; Male; Methotrexate; Muscles; Muscular Diseases; Neoplasms; Prednisone | 1973 |
Results in 169 patients with cancer of the head and neck treated by intra-arterial infusion therapy.
Topics: Antineoplastic Agents; Brachial Artery; Brachiocephalic Trunk; Carcinoma, Squamous Cell; Carotid Artery, Internal; Catheterization; Cyclophosphamide; Dactinomycin; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Laryngeal Neoplasms; Melanoma; Methods; Methotrexate; Mouth Neoplasms; Neoplasms; Osteosarcoma; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Skin Neoplasms; Skull Neoplasms; Vinblastine | 1972 |
Intra-arterial infusion for head and neck cancers.
Topics: Aged; Antineoplastic Agents; Brachiocephalic Trunk; Carcinoma, Squamous Cell; Carotid Arteries; Catheterization; Female; Fluoresceins; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Leukocyte Count; Male; Methods; Methotrexate; Neoplasm Recurrence, Local; Neoplasms; Vinblastine | 1973 |
Treatment of head and neck cancer with intra-arterial cytotoxic drugs and radiotherapy.
Topics: Antineoplastic Agents; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Methotrexate; Neoplasms; Thiotepa; Time Factors; Vinblastine | 1972 |
Cancer chemotherapy. I. Methods, agents and overall results in 400 patients.
Topics: Adenocarcinoma; Amides; Androgens; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Estrogens; Female; Fluorouracil; Glucocorticoids; Head; Head and Neck Neoplasms; Humans; Imidazoles; Lung Neoplasms; Male; Mechlorethamine; Melanoma; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Progesterone; Rectal Neoplasms; Sarcoma; Thiotepa; Triazenes | 1972 |
[Acid-base equilibrium under cytostatic therapy].
Topics: Acid-Base Equilibrium; Adolescent; Adult; Aged; Antineoplastic Agents; Cyclophosphamide; Female; Fluorouracil; Humans; Hydrogen-Ion Concentration; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms; Vinblastine | 1972 |
1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) given alone and combined with antimetabolites in the treatment of advanced solid tumors.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Cystadenoma; Cytarabine; Female; Humans; Leukopenia; Lung Neoplasms; Male; Methotrexate; Nausea; Neoplasm Metastasis; Neoplasms; Nitrosourea Compounds; Ovarian Neoplasms; Stomach Neoplasms; Vomiting | 1972 |
Study on the sensitivity test of carcinostatic agents by acid phosphatase activity.
Topics: Acid Phosphatase; Adult; Aged; Animals; Antineoplastic Agents; Chromomycins; Cyclophosphamide; Female; Fluorouracil; Humans; Male; Mechlorethamine; Methotrexate; Mice; Middle Aged; Mitomycins; Neoplasms; Neoplasms, Experimental; Rats; Stomach Neoplasms; Vincristine | 1972 |
Quantitative monitoring of chemotherapy of endocrine tumors by hormone assay.
Topics: Adrenal Gland Neoplasms; Butanones; Female; Hormones; Humans; Methotrexate; Neoplasms; Pregnancy | 1972 |
Lecithin-sphingomyelin ratio changes with estrogen or glucocorticoid treatment.
Topics: Amniotic Fluid; Dexamethasone; Female; Humans; Methotrexate; Neoplasms; Phosphatidylcholines; Pregnancy; Sphingomyelins | 1973 |
Determination of therapeutic index of drugs by in vitro sensitivity tests using human host and tumor cell suspensions.
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Humans; In Vitro Techniques; Methotrexate; Neoplasms; Penicillamine; Thymidine; Time Factors; Tritium | 1973 |
Use of plasma-free medium for the in vitro culture of human lymphocytes.
Topics: Adult; Aged; Arsenicals; Cells, Cultured; Culture Media; Female; Humans; Hydrocortisone; Immunity, Cellular; Insulin; Lectins; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Methylcellulose; Neoplasms; Penicillins; Plasma; Streptomycin; Thymidine; Tritium | 1973 |
Methrotrexate U.S.P. (amethopterin) and methotrexate sodium.
Topics: Abortion, Induced; Anemia; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Choriocarcinoma; Drug Interactions; Female; Humans; Leukemia; Leukopenia; Male; Methotrexate; Neoplasms; Pregnancy; Psoriasis; Skin Diseases; Testicular Neoplasms; Thrombocytopenia; Uric Acid; Uterine Neoplasms | 1973 |
Combination therapy of solid tumors using 1,3-bis(2-chloroethyl)-1-nitrosourea (NCNU), vincristine, methotrexate, and 5-fluorouracil.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Carmustine; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms; Thyroid Neoplasms; Uterine Neoplasms; Vincristine | 1973 |
Results in fifty cases of advanced squamous cell carcinoma of the head and neck treated by intravenous chemotherapy.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Combinations; Epiglottis; Female; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Leukopenia; Male; Methotrexate; Middle Aged; Mouth Neoplasms; Nasopharyngeal Neoplasms; Nausea; Neoplasms; Tongue Neoplasms; Vincristine | 1973 |
[Mutilating subungual warts. Healing through methotrexate].
Topics: Adult; Alopecia; Bone Diseases; Female; Fingers; Humans; Keratosis; Methotrexate; Nails; Neoplasms; Papilloma; Radiography; Time Factors; Transaminases; Warts | 1973 |
Multiple-drug therapy for malignant solid tumors in adults.
Topics: Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Humans; Leukopenia; Methotrexate; Neoplasms; Thrombocytopenia; Vincristine | 1973 |
[Effect of cytostatic agents on cell suspensions of human malignant tumors in the animal experiment].
Topics: Animals; Antibody Formation; Antineoplastic Agents; Cytotoxicity Tests, Immunologic; Female; Humans; Male; Methotrexate; Neoplasm Transplantation; Neoplasms; Rats; Transplantation Immunology; Transplantation, Heterologous; Transplantation, Homologous | 1973 |
[Therapy of metastasizing solid tumors with cyclophosphamide, methotrexate, vincristine and 5-fluorouracil].
Topics: Adolescent; Adult; Aged; Cyclophosphamide; Female; Fluorouracil; Humans; Male; Methods; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms; Vincristine | 1973 |
Cancer chemotherapy by intra-arterial infusion with adriamycin.
Topics: Adult; Alopecia; Anemia; Doxorubicin; Electrocardiography; Female; Femoral Artery; Fluorouracil; Heart; Humans; Infusions, Parenteral; Injections, Intra-Arterial; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasms; Thrombocytopenia | 1973 |
[Attempt at the prevention of lymphosarcoma penetration into the central nervous system].
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Female; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Metastasis; Neoplasms | 1973 |
Biological characterization of human tumours by means of organ culture and individualized cytostatic cancer treatment.
Topics: Antineoplastic Agents; Biological Assay; Biopsy; Dose-Response Relationship, Drug; Female; Fluorouracil; Humans; Male; Melphalan; Methotrexate; Neoplasms; Organ Culture Techniques; Triaziquone; Vinblastine; Vincristine | 1973 |
The immunotherapy of advanced human cancer with neuraminidase.
Topics: Adult; BCG Vaccine; Breast Neoplasms; Drug Combinations; Female; Freund's Adjuvant; Humans; Immunotherapy; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Neoplasms; Neuraminidase; Nigeria; Prognosis; Vibrio cholerae | 1973 |
Cutaneous reactivity in patients with cancer of the head and neck region.
Topics: Age Factors; Aged; Carcinoma, Squamous Cell; Croton Oil; Dinitrochlorobenzene; Drug Hypersensitivity; Head; Head and Neck Neoplasms; Humans; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasms; Prognosis; Skin Tests | 1973 |
[Molecular and cellular bases of cytostatic therapy].
Topics: Antibiotics, Antineoplastic; Antimetabolites; Asparaginase; Asparagine; Cell Division; Cell Line; Cells; DNA; DNA, Neoplasm; Humans; Methotrexate; Neoplasms; Nitrogen; Protein Biosynthesis; RNA; RNA, Neoplasm | 1974 |
The effects of chemotherapy on the morphology of solid tumours.
Topics: Antineoplastic Agents; Cell Division; Cell Nucleus; Cells; Cytarabine; Hydroxyurea; Intestinal Mucosa; Intestine, Small; Methotrexate; Microscopy, Electron; Mitosis; Neoplasms; Phagocytosis; Time Factors; Vinca Alkaloids | 1974 |
The pathogenesis of folic acid deficiency in man.
Topics: Adolescent; Adult; Aged; Alcoholism; Anemia, Macrocytic; Animals; Anticonvulsants; Celiac Disease; Child; Diet; Female; Folic Acid; Folic Acid Deficiency; Hematologic Diseases; Humans; Inflammation; Liver; Male; Metabolic Diseases; Methotrexate; Neoplasms; Pregnancy | 1974 |
[Chemotherapy of cancer. Hints for continuing medical education].
Topics: Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Cytarabine; Daunorubicin; Education, Medical, Continuing; Fluorouracil; Humans; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Procarbazine; Triaziquone; Vinblastine; Vincristine | 1974 |
[Clinical picture of rheumatologic diseases. Current status of cytostatic therapy].
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Humans; Immunosuppression Therapy; Methotrexate; Neoplasms; Penicillamine; Time Factors; Triaziquone | 1974 |
Plasma levels of methotrexate in cancer patients as studied by an improved spectrophotofluorometric method.
Topics: Adult; Aged; Chromatography, Ion Exchange; Creatinine; Cytarabine; Diatrizoate; Female; Folic Acid; Heparin; Humans; Hydrogen-Ion Concentration; Male; Methods; Methotrexate; Middle Aged; Neoplasms; Oxidation-Reduction; Potassium Permanganate; Spectrometry, Fluorescence; Time Factors; Triamterene; Tritium; Tryptophan; Tungsten | 1974 |
Selective cell survival and changes of marker properties during cryopreservation for up to 16 years.
Topics: Animals; Cell Division; Cell Line; Cell Nucleus; Cell Survival; Chromosomes; Clone Cells; Culture Techniques; Freezing; Histocompatibility Antigens; Humans; Lymphoma; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Polyploidy; Sarcoma 180; Species Specificity; Time Factors; Tissue Preservation; Transplantation, Homologous | 1974 |
[Progress in chemotherapy of solid tumors and malignant lymphomas (continued)].
Topics: Adult; Antineoplastic Agents; Carcinoma; Choriocarcinoma; Female; Fluorouracil; Gonadal Steroid Hormones; Hodgkin Disease; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasms; Pregnancy | 1967 |
Immunosuppressive effects of cytosine arabinoside and methotrexate in man.
Topics: Adult; Aged; Antibody Formation; Cytarabine; Escherichia coli; Female; Humans; Immunosuppressive Agents; Lymphocytes; Male; Methotrexate; Middle Aged; Neoplasms; Tetanus Toxoid | 1969 |
Immunosuppressive drugs. I.
Topics: Adrenal Cortex Hormones; Animals; Antibodies; Antibody Formation; Antilymphocyte Serum; Antineoplastic Agents; Azathioprine; Cyclophosphamide; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Immunoglobulins; Immunosuppressive Agents; Kidney Transplantation; Mercaptopurine; Methotrexate; Neoplasms; Skin Transplantation; Transplantation Immunology | 1970 |
Clinical experience with L-asparaginase.
Topics: Adolescent; Adult; Aged; Asparaginase; Azaserine; Burkitt Lymphoma; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Escherichia coli; Female; Humans; Leukemia, Lymphoid; Leukopenia; Lymphoma, Non-Hodgkin; Lymphopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasms; Pancreatitis; Thrombocytopenia | 1970 |
[New possibilities in testing resistance of human carcinoma tissue to cytostatic agents in vivo].
Topics: Animals; Cyclophosphamide; Humans; Methotrexate; Neoplasm Transplantation; Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllin; Podophyllum; Rats; Thiotepa; Triaziquone | 1967 |
[Long-term intravenous administration of methotrexate Spofa in malignant tumors].
Topics: Humans; Infusions, Parenteral; Long-Term Care; Methotrexate; Neoplasms | 1968 |
[The chemotherapy of cancer].
Topics: Adult; Alkylating Agents; Antimetabolites; Antineoplastic Agents; Dactinomycin; Female; Fluorouracil; Hodgkin Disease; Humans; Lung Neoplasms; Male; Melphalan; Methotrexate; Middle Aged; Neoplasms; Phytotherapy; Plants, Medicinal; Plants, Toxic; Podophyllum; Radiography; Sarcoma, Ewing; Thiotepa; Vincristine | 1967 |
Regional protection in cancer chemotherapy: an experimental study in monkeys.
Topics: Animals; Antibiotics, Antineoplastic; Bone Marrow; Bone Marrow Cells; Haplorhini; Ileum; Injections, Intra-Arterial; Injections, Intramuscular; Injections, Intravenous; Intestinal Mucosa; Intubation, Gastrointestinal; Methotrexate; Neoplasms | 1969 |
Chemotherapy and radiation therapy together to treat cancer.
Topics: Antineoplastic Agents; Cell Division; Cyclophosphamide; DNA, Neoplasm; Female; Fluorouracil; Heparin; Humans; Hyperbaric Oxygenation; Injections, Intra-Arterial; Injections, Intravenous; Male; Methotrexate; Neoplasms; Nitrogen; Oxygen; Perfusion; Phlebitis; Therapeutic Irrigation; Thiotepa; Time Factors; Vinblastine | 1970 |
[Chemotherapy of solid tumors].
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Fluorouracil; Humans; Melanoma; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Skin Neoplasms; Thiotepa | 1970 |
Cell proliferation and the differential response of normal and malignant tissues. Silvanus Thompson Memorial Lecture.
Topics: Animals; Blood Vessels; Busulfan; Cell Survival; Cyclophosphamide; Cytarabine; Diffusion; Epithelial Cells; Epithelium; Fibrosarcoma; Hematopoietic Stem Cells; Intestine, Small; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Mitosis; Necrosis; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms; Oxygen; Radiation Effects; Rats | 1972 |
Regional chemotherapy and local cryotherapy for cancer.
Topics: Adult; Aged; Animals; Carcinoma, Squamous Cell; Colon; Cryosurgery; Dogs; Female; Head and Neck Neoplasms; Humans; Ileum; Injections, Intra-Arterial; Male; Methods; Methotrexate; Methylene Blue; Middle Aged; Mouth Neoplasms; Neoplasms; Tongue Neoplasms | 1972 |
Treatment of squamous cell carcinoma of the head and neck by chemotherapy.
Topics: Administration, Oral; Carcinoma, Squamous Cell; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Injections, Intravenous; Methotrexate; Neoplasm Metastasis; Neoplasms; Radiography | 1972 |
Intra-arterial infusion. A seven-year study.
Topics: Carcinoma, Squamous Cell; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Iowa; Methotrexate; Neoplasms | 1972 |
Chemotherapy in the management of metastatic cancer of unknown primary site.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms; Prednisone; Vincristine | 1972 |
Expectations and pitfalls of chemotherapy in a university cancer clinic.
Topics: Breast Neoplasms; Cyclophosphamide; Female; Fluorouracil; Gastrointestinal Neoplasms; Hospitals, Teaching; Humans; Lung Neoplasms; Male; Melanoma; Methotrexate; Neoplasms; Outpatient Clinics, Hospital; Sarcoma; South Carolina; Vincristine | 1972 |
[Clinical aspects of immunosuppressive therapy in childhood rheumatoid arthritis].
Topics: Adrenal Cortex Hormones; Alkylating Agents; Arthritis, Juvenile; Azathioprine; Child; Humans; Immunity, Cellular; Immunosuppression Therapy; Methotrexate; Neoplasms; Penicillamine | 1972 |
Methotrexate toxicity: correlation with duration of administration, plasma levels, dose and excretion pattern.
Topics: Alanine Transaminase; Blood Cell Count; Humans; Injections, Intravenous; Methotrexate; Neoplasms; Time Factors | 1972 |
Drugs used in radiotherapy.
Topics: Adenine; Alkylating Agents; Analgesics; Anemia; Anti-Bacterial Agents; Antiemetics; Antimetabolites; Antineoplastic Agents; Drug Therapy; Expectorants; Folic Acid; Humans; Mercaptopurine; Methotrexate; Neoplasms; Pharmaceutical Preparations; Radiotherapy; Steroids; Tranquilizing Agents; Vitamins | 1972 |
Methotrexate plus Bacillus Calmette-Guérin (BCG) and isoniazid in the treatment of cancer of the head and neck.
Topics: Adult; Aged; BCG Vaccine; Carcinoma, Squamous Cell; Cyclophosphamide; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Injections, Intravenous; Isoniazid; Laryngeal Neoplasms; Lip Neoplasms; Male; Methotrexate; Middle Aged; Mouth Floor; Mouth Neoplasms; Neoplasms; Tonsillar Neoplasms | 1972 |
The effect of operative treatment, chemotherapy, and oestrogens on the phagocytic activity of the reticuloendothelial system.
Topics: Aged; Antineoplastic Agents; Cyclophosphamide; Diethylstilbestrol; Estradiol; Fluorouracil; Half-Life; Humans; Methotrexate; Middle Aged; Mononuclear Phagocyte System; Neoplasms; Phagocytosis; Serum Albumin, Radio-Iodinated; Surgical Procedures, Operative | 1972 |
Comment: radiosensitization and the selective effect.
Topics: Drug Synergism; Humans; Hyperbaric Oxygenation; Methotrexate; Neoplasms; Neutrons; Nucleic Acids; Oxygen; Radiation Effects; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy Dosage; Time Factors | 1971 |
Multiple drug therapy for disseminated malignant tumours.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Child; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Synergism; Female; Fluorouracil; Humans; Leukocyte Count; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Neoplasms; Remission, Spontaneous; Urinary Bladder Neoplasms; Vincristine | 1971 |
[Hair changes in immunosuppressive therapy].
Topics: Antineoplastic Agents; Azathioprine; Chlorambucil; Cyclophosphamide; Hair; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Melphalan; Mercaptopurine; Methotrexate; Neoplasms; Scleroderma, Systemic; Skin Diseases; Vinblastine | 1971 |
In vivo prediction of drug sensitivity with cancer-seeking isotopes.
Topics: Amides; Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma 256, Walker; Cyclophosphamide; Deoxyuridine; Diethylstilbestrol; Female; Fluorouracil; Fluoxymesterone; Humans; Imidazoles; Iodine Radioisotopes; Methotrexate; Neoplasms; Nitrosourea Compounds; Phosphates; Rats; Serum Albumin, Radio-Iodinated; Sodium Isotopes; Triazenes; Vincristine | 1971 |
[Delayed hypersensitivity reaction to 2,4-dinitrochlorobenzol in cancer patients undergoing cytostatic chemotherapy].
Topics: Age Factors; Aged; Bronchial Neoplasms; Carcinoma; Cyclophosphamide; Drug Antagonism; Fractures, Bone; Humans; Hypersensitivity, Delayed; Immunosuppression Therapy; Lymphoma; Methotrexate; Middle Aged; Neoplasms; Nitrobenzenes; Prednisone; Prognosis; Vascular Diseases | 1971 |
Seventy-five cases of solid tumours treated by a modified quadruple chemotherapy regime.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Bronchial Neoplasms; Child; Cyclophosphamide; Female; Fluorouracil; Gastrointestinal Neoplasms; Head; Head and Neck Neoplasms; Humans; Infant; Injections, Intravenous; Male; Melanoma; Methotrexate; Middle Aged; Neoplasms; Ovarian Neoplasms; Sarcoma; Testicular Neoplasms; Uterine Cervical Neoplasms; Vincristine | 1971 |
Intra-arterial chemotherapy with surgery or radiotherapy in tumours of the head-neck region.
Topics: Fluorouracil; Head; Head and Neck Neoplasms; Injections, Intra-Arterial; Methotrexate; Neoplasms | 1971 |
[Chimiotherapy of cancers (operational research of its efficiency and its place in therapeutic strategy of neoplasic diseases)].
Topics: Agranulocytosis; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Daunorubicin; Humans; Immunosuppressive Agents; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukocyte Count; Methotrexate; Neoplasms; Neoplastic Cells, Circulating; Prednisone; Vinblastine; Vincristine | 1969 |
Comparative sensitivity to various antimetabolites of several established cell lines derived from the buffy coat of normal humans and patients with neoplastic diseases.
Topics: Antimetabolites; Blood Cells; Cell Line; Culture Techniques; Cytarabine; Fluorouracil; Humans; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Mitosis; Neoplasms | 1969 |
Intra-arterial infusion of the chemotherapeutic agents methotrexate and "epodyl" in patients with advanced localized carinomata recurrent after radiotherapy.
Topics: Aged; Alkylating Agents; Arteries; Female; Glycols; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Male; Methotrexate; Middle Aged; Neoplasms; Radiotherapy | 1970 |
Bar-shaped nuclear bodies in oral epithelial cells of children receiving chemotherapy for cancer.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Chromatin; Cyclophosphamide; Daunorubicin; Female; Humans; Male; Mercaptopurine; Methotrexate; Mouth Mucosa; Neoplasms; Prednisone; Procarbazine; Vincristine | 1971 |
The effect of methotrexate (amethopterin) on wound healing: an experimental study.
Topics: Animals; Cyclophosphamide; Fluorouracil; Leucovorin; Methotrexate; Neoplasms; Rats; Wound Healing | 1965 |
A portable pump ("conjector") for regional perfusion cancer chemotherapy.
Topics: Antineoplastic Agents; Blood Cell Count; Chemotherapy, Cancer, Regional Perfusion; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Neoplasms | 1966 |
[High doses of methotrexate followed by folinic acid in acute leukemia and solid tumors].
Topics: Acute Disease; Drug Synergism; Humans; Injections, Intravenous; Leucovorin; Leukemia; Methotrexate; Neoplasms | 1970 |
Historic and current intra-arterial chemotherapy.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Catheterization; Chemotherapy, Cancer, Regional Perfusion; Extremities; Female; Fluorouracil; Follow-Up Studies; Head; Head and Neck Neoplasms; Humans; Injections, Intra-Arterial; Leucovorin; Liver Neoplasms; Male; Mechlorethamine; Methotrexate; Neoplasms; Pelvic Neoplasms; Thoracic Neoplasms | 1970 |
[Operational procedure of antineoplastic chemotherapy by administering high doses of an antimetabolite and its antidote].
Topics: Antidotes; Female; Hodgkin Disease; Humans; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Neoplasms | 1971 |
Toxic and therapeutic effects of methotrexate-folinic acid (Leucovorin) in advanced cancer and leukemia.
Topics: Breast Neoplasms; Choriocarcinoma; Female; Head; Head and Neck Neoplasms; Humans; Leucovorin; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Pregnancy; Remission, Spontaneous; Uterine Cervical Neoplasms | 1971 |
Skin homograft survival in cancer chemotherapy patients.
Topics: Adult; Aged; Antineoplastic Agents; Carbamates; Female; Fluorouracil; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Mitomycins; Neoplasms; Skin Transplantation; Transplantation, Homologous; Urea | 1966 |
The application of new knowledge to the effective administration of anticancer agents.
Topics: Animals; Antineoplastic Agents; Computers; Methotrexate; Models, Biological; Models, Theoretical; Neoplasms | 1969 |
New approaches in administration of anticancer drugs.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Cytarabine; Female; Fluorouracil; Humans; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasms; Prognosis; Time Factors | 1969 |
Clinical and experimental evaluation of urinary histidine derivatives as an index of folic acid metabolism. II. The observation in neoplastic diseases with or without methotrexate administration.
Topics: Adult; Aged; Animals; Blood Cell Count; Blood Platelets; Dogs; Female; FIGLU Test; Folic Acid; Histidine; Humans; Leukocyte Count; Liver Neoplasms; Lung Neoplasms; Male; Methotrexate; Middle Aged; Neoplasms | 1969 |
Thrombocytosis following thrombocytopenia in man.
Topics: Anemia, Pernicious; Humans; Methotrexate; Neoplasms; Prednisone; Purpura, Thrombocytopenic; Thrombocytopenia; Thrombocytosis; Vitamin B 12 | 1969 |
[Association of cytotoxic agents with radiotherapy: experimental bases and initial results in solid tumors].
Topics: Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Drug Synergism; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Methotrexate; Neoplasms; Respiratory Tract Neoplasms; Vinblastine | 1969 |
A study of the distribution of methotrexate in human tissues and tumors.
Topics: Breast Neoplasms; Carcinoma; Humans; Injections, Intra-Arterial; Injections, Intravenous; Leiomyosarcoma; Methotrexate; Neoplasms; Skin; Tritium | 1970 |
Combined chemotherapy of epithelial tumours.
Topics: Breast Neoplasms; Cobalt Isotopes; Cyclophosphamide; Dactinomycin; DNA, Neoplasm; Female; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasms; Prednisone; Radiotherapy Dosage; RNA, Messenger; Testicular Neoplasms | 1970 |
Clinical immunologic responsiveness in malignant disease. I. Delayed hypersensitivity reaction and the effect of cytotoxic drugs.
Topics: Adolescent; Adult; Aged; Antigens; Antineoplastic Agents; Breast Neoplasms; Candida; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hypersensitivity, Delayed; Immunosuppressive Agents; Leukopenia; Lung Neoplasms; Male; Methotrexate; Middle Aged; Mumps virus; Neoplasms; Nitrobenzenes; Ovarian Neoplasms; Skin Tests; Tuberculin; Uterine Cervical Neoplasms; Vinblastine | 1970 |
Infusion chemotherapy.
Topics: Antineoplastic Agents; Arm; Carcinoma, Squamous Cell; Colonic Neoplasms; Head; Head and Neck Neoplasms; Humans; Leg; Liver Neoplasms; Methods; Methotrexate; Neoplasms | 1970 |
Phase I and preliminary phase II evaluation of adriamycin (NSC 123127).
Topics: Adolescent; Adult; Aged; Alopecia; Anthraquinones; Antibiotics, Antineoplastic; Bone Marrow Diseases; Child; Child, Preschool; Female; Humans; Leukemia; Male; Methotrexate; Middle Aged; Neoplasms; Prednisolone; Stomatitis; Time Factors; Vincristine | 1970 |
Methotrexate in the treatment of tumours of the oto-rhino-laryngeal region.
Topics: Humans; Injections, Intravenous; Methotrexate; Neoplasms; Otorhinolaryngologic Diseases | 1970 |
Preferential attack on cancer following major cancer surgery.
Topics: Agar; Alkylating Agents; Antineoplastic Agents; Culture Techniques; DNA, Neoplasm; Fluorouracil; Humans; Mechlorethamine; Methods; Methotrexate; Neoplasms; Neoplastic Cells, Circulating; Radioisotopes; Sulfhydryl Compounds | 1971 |
Further clinical studies of combination chemotherapy using cyclophosphamide, vincristine, methotrexate and 5-flourouracil in solid tumors.
Topics: Cyclophosphamide; Fluorouracil; Humans; Methotrexate; Neoplasms; Vincristine | 1971 |
Treatment of advanced cancer of head and neck by large doses of methotrexate.
Topics: Administration, Oral; Head; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Methotrexate; Mouth Neoplasms; Neoplasm Metastasis; Neoplasms; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Skin Neoplasms | 1971 |
[Combined cytostatic treatment of solid tumours with cyclophosphamide (Endoxan), vincristine, methylaminopterin (Methotrexate) and 5-fluorouracil].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Enteritis; Fluorouracil; Humans; Methotrexate; Middle Aged; Neoplasms; Neuritis; Remission, Spontaneous; Stomatitis; Vincristine | 1971 |
[Anticancer chemotherapy and its place in the treatment of cancer].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Drug Synergism; Female; Humans; Leukemia; Male; Methotrexate; Mice; Neoplasms; Neoplasms, Experimental; Vinblastine | 1971 |
[Organ transplants and tumors].
Topics: Angiography; Antineoplastic Agents; Extracorporeal Circulation; Humans; Immune Tolerance; Immunosuppressive Agents; Methods; Methotrexate; Neoplasms; Radioisotope Teletherapy; Transplantation Immunology | 1971 |
[Trial of anticancerous polychemotherapy associating amethopterin, vinblastine and cyclophosphamide].
Topics: Adult; Aged; Cyclophosphamide; Drug Synergism; Drug Tolerance; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasms; Vinblastine | 1971 |
[Combined chemotherapy of solid tumors].
Topics: Cyclophosphamide; Fluorouracil; Humans; Methotrexate; Neoplasms; Vincristine | 1971 |
[Polychemotherapy of the advanced stages of malignant proliferative disorders].
Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasms; Vincristine | 1971 |
Some considerations of folic acid antagonists.
Topics: Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Methotrexate; Neoplasms | 1971 |
Malignancy during methotrexate and steroid therapy for psoriasis.
Topics: Adult; Carcinoma, Squamous Cell; Humans; Immunosuppression Therapy; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Neoplasms; Prednisone; Psoriasis; Radiography; Skin Neoplasms | 1971 |
Methotrexate-induced carcinoma?
Topics: Carcinoma, Transitional Cell; Humans; Immunosuppression Therapy; Male; Methotrexate; Middle Aged; Nasopharyngeal Neoplasms; Neoplasms; Psoriasis | 1971 |
Advances in the management of tumors of the head and neck.
Topics: Carcinoma, Squamous Cell; Cobalt Isotopes; Head; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Methotrexate; Neoplasms; Preoperative Care; Radioisotope Teletherapy; Radiotherapy | 1967 |
[Chemotherapy of neoplasms].
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cyclophosphamide; Estrogens; Humans; Mercaptopurine; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds | 1967 |
Nonhormonal cancer chemotherapy and the vaginal smear.
Topics: Female; Fluorouracil; Humans; Methotrexate; Neoplasms; Vagina; Vaginal Smears | 1967 |
[Internal cancer therapy: cooperative clinical studies. Principles, organization and first results of the Swiss chemotherapy group].
Topics: Adenocarcinoma; Androgens; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Bronchogenic; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Methotrexate; Neoplasm Metastasis; Neoplasms; Switzerland | 1967 |
Methotrexate and the platelet count.
Topics: Antineoplastic Agents; Azathioprine; Blood Cell Count; Blood Platelets; Fluorouracil; Humans; Leukopenia; Methotrexate; Neoplasms; Thrombocytopenia; Thrombocytosis; Time Factors | 1968 |
Changes in 32P counting-rate in human and animal tumours.
Topics: Androgens; Animals; Circadian Rhythm; Cortisone; Epinephrine; Estrogens; Female; Humans; Male; Mammary Neoplasms, Experimental; Methods; Methotrexate; Mice; Neoplasms; Periodicity; Phosphorus; Phosphorus Isotopes | 1968 |
[Hepatotoxicity of antimitotic treatments. Effect of hepatic tests].
Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorambucil; Cyclophosphamide; Female; Humans; Liver Function Tests; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Middle Aged; Mitomycins; Neoplasms; Rats; Urethane; Vinblastine; Vincristine | 1968 |
Some observations on the combined effects of x-rays and methotrexate on human tumor cells in vitro with possible relevance to their most useful combination in radiotherapy.
Topics: DNA, Neoplasm; Female; HeLa Cells; Humans; In Vitro Techniques; Methotrexate; Neoplasms; Nitrogen; Oxygen; Radiotherapy Dosage; Time Factors; Uterine Cervical Neoplasms | 1968 |
Tumour growth and anti-mitotic action. The role of spontaneous cell losses.
Topics: Antineoplastic Agents; DNA, Neoplasm; Growth; Humans; In Vitro Techniques; Methotrexate; Mitosis; Models, Biological; Neoplasm Regression, Spontaneous; Neoplasms | 1968 |
131-I-3'-iodoaminopterin: a gamma-labeled active-site-directed enzyme inhibitor.
Topics: Adult; Aged; Aminopterin; Binding Sites; Chromatography; Female; Folic Acid Antagonists; Humans; Injections, Intravenous; Iodine Isotopes; Kidney; Liver; Male; Methods; Methotrexate; Neoplasms; Radionuclide Imaging; Tetrahydrofolate Dehydrogenase; Thyroid Gland | 1968 |
[The association of small doses of vincristine with methotrexate in large doses in the therapy of solid tumors].
Topics: Female; Humans; Leukemia; Male; Methotrexate; Neoplasms; Vincristine | 1968 |
[Intra-arterial infusion of amethopterin in O.R.L.: indications and method].
Topics: Humans; Injections, Intra-Arterial; Methotrexate; Neoplasms; Otorhinolaryngologic Diseases | 1968 |
The effect of cytotoxic agents on human tumours transplanted to the hamster cheek pouch.
Topics: Animals; Blood Vessels; Cheek; Cricetinae; Female; Growth; Humans; Male; Mechlorethamine; Methotrexate; Neoplasm Transplantation; Neoplasms; Transplantation, Heterologous | 1969 |
Malignant lymphomas following allogenic disease: transition from an immunological to a neoplastic disorder.
Topics: Animals; Immune Tolerance; In Vitro Techniques; Lymphoma; Methotrexate; Neoplasm Transplantation; Neoplasms; Spleen; Transplantation Immunology | 1965 |
Inhibition of the primary immune response in man by anti-metabolites.
Topics: Antibodies; Antigens; Antimetabolites; Antineoplastic Agents; Humans; Immunosuppressive Agents; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Prednisone; Uveitis; Vincristine | 1965 |
[Radiotherapy-oral methotrexate association in cancers of the head and neck].
Topics: Humans; Methotrexate; Neoplasms; Otorhinolaryngologic Diseases | 1965 |
Sequential chemotherapy and radiotherapy. Preliminary results of clinical trial with methotrexate in head and neck cancer.
Topics: Head; Head and Neck Neoplasms; Humans; Methotrexate; Neoplasms | 1966 |
Inhibition of the local inflammatory response in man by antimetabolites.
Topics: Antimetabolites; Humans; Inflammation; Leukemia; Mercaptopurine; Methotrexate; Neoplasms; Uveitis | 1966 |
The chemotherapy of cancer in children.
Topics: Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Humans; Hydrazines; Mechlorethamine; Methotrexate; Neoplasms; Vinblastine; Vincristine | 1966 |
Cancer chemotherapy by continuous intra-arterial infusion of methotrexate.
Topics: Aged; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; In Vitro Techniques; Male; Methotrexate; Middle Aged; Mouth Neoplasms; Neoplasms; Urinary Bladder Neoplasms | 1966 |
Methotrexate and folic reductase in human cancer.
Topics: Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 1966 |