methotrexate has been researched along with Asthma, Bronchial in 115 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (6.96) | 18.7374 |
| 1990's | 73 (63.48) | 18.2507 |
| 2000's | 17 (14.78) | 29.6817 |
| 2010's | 15 (13.04) | 24.3611 |
| 2020's | 2 (1.74) | 2.80 |
| Authors | Studies |
|---|---|
| Adam, DN; Beecker, JR; Gooderham, MJ; Hong, CH; Jack, CS; Jain, V; Lansang, P; Lynde, CW; Papp, KA; Prajapati, VH; Turchin, I; Yeung, J | 1 |
| Hashiramoto, A; Yamane, T | 1 |
| Garus, B; Kopczyński, J; Pasiarski, M; Skowronek, M; Stelmach-Gołdyś, A; Trzpiot, S | 1 |
| Bilocca, D; Bradding, P; Brightling, CE; Green, RH; Hargadon, B; Martin, N; Murphy, AC; Pavord, ID; Siddiqui, S; Wardlaw, AJ | 1 |
| George, M; Kitzmiller, J; Korbel, L | 1 |
| Dahl, R; Hilberg, O; Knarborg, M | 2 |
| Chung, KF | 1 |
| Alamo, A; Bellinvia, S; Caruso, M; Domingo, C; Emma, R; Kowalski, ML; Polosa, R | 1 |
| Kusumgar, P; Monappa, V; Vijaya, PH | 1 |
| Fardet, L; Mazaud, C | 1 |
| Hutas, G | 1 |
| Amengual, MJ; Comet, R; Domingo, C; Luján, M; Moreno, A | 1 |
| Aslan, I; Aydin, S; Buyukozturk, S; Colakoglu, B; Dal, M; Gelincik, A | 1 |
| Hillman, T; Murphy, P; Rajakulasingam, K | 1 |
| Bush, A; Saglani, S | 1 |
| Altintop, L; Bektas, A; Cakar, B; Hokelek, M; Karaoglanoglu, M; Yildiz, L | 1 |
| Domingo, C; Mirapeix, R; Moreno, A | 1 |
| Armstrong, S; Avery, AJ; Boyd, M; Cantrill, JA; Cresswell, K; Eden, M; Elliott, RA; Franklin, M; Howard, R; Kendrick, D; Morris, CJ; Prescott, RJ; Putman, K; Rodgers, S; Sheikh, A; Swanwick, G | 1 |
| Cornblath, WT; De Lott, LB; Elner, VM; Harris Nwanyanwu, KM | 1 |
| Argyros, G; Niven, AS | 1 |
| Kon, OM | 1 |
| Corrigan, CJ; Ind, PW; Shakur, BH; Shiner, R | 1 |
| Gross, WL; Hellmich, B | 1 |
| Girgis, SI; Ind, PW; Nwokeji, A; Shakur, BH; Shiner, RJ | 1 |
| Corrigan, CJ; Ind, PW; Shakur, BH; Shiner, RJ | 1 |
| Amengual, MJ; Comet, R; Domingo, C; Larrosa, M; Marín, A; Morón, A; Rué, M | 1 |
| Virchow, JC | 1 |
| Alvarez, C; Ferreira, A; Gatica, H; Goecke, IA; Henríquez, J; Molina, ML; Salas, K | 1 |
| Kalmanti, M; Katzilakis, N; Mantadakis, E; Paraskakis, E; Stiakaki, E | 1 |
| Kanzow, G; Magnussen, H; Nowak, D | 1 |
| Aldrich, TK; Finkel, RI; Keane, AM; Meller, FF; Ogirala, RG; Pacia, EB; Sturm, TM | 1 |
| Hill, JM; Tattersfield, AE | 1 |
| Carratù, L; Molino, A; Mormile, M; Sofia, M; Stanziola, A | 1 |
| Dalhoff, K; Gross, WL; Mrowietz, U; Schnabel, A; Stange, EF | 1 |
| Dahl, R | 1 |
| Evald, T; Larsen, KR; Midtgaard, C | 1 |
| Adachi, M; Gonokami, Y; Konno, SI; Kurokawa, M | 1 |
| Connolly, CK; Gatnash, AA | 1 |
| Benzaray, S; Katz, I; Shiner, RJ; Shulimzon, T; Silkoff, P | 1 |
| Becquart, LA; Guéné-Ribassin, C; Lassalle, P; Tonnel, AB; Wallaert, B | 1 |
| Tsai, JJ; Wang, SR; Wang, TF | 1 |
| Moss, RB | 1 |
| Coffey, MJ; Eschenbacher, WL; McCune, WJ; Ramesh, S; Sanders, G; Toews, GB; Tsien, A; Weber, RW | 1 |
| Adachi, M; Gonokami, Y; Kobayashi, H; Konno, S | 1 |
| Diaz, JD; Ledford, DK; Lockey, RF; Seleznick, MJ; Stewart, GE; Trudeau, WL | 1 |
| Reisman, JJ | 1 |
| Delclaux, B; Derenne, JP; Whitelaw, WA | 1 |
| Cott, GR | 1 |
| Aalbers, R; Walker, C; Yntema, JL | 1 |
| Bardin, PG; Beasley, RW; Fraenkel, DJ | 1 |
| Reid, DJ; Segars, LW | 1 |
| Flannery, EM; Herbison, GP; Taylor, DR | 1 |
| Cash, JM | 1 |
| Chen, CH; Shin, JF; Tsai, JJ; Wang, SR | 1 |
| García Río, FJ; Satué, JL; Vázquez, M | 1 |
| Davies, RJ; Trigg, CJ | 1 |
| Lai, WK; Morice, AH | 1 |
| Charpin, D; Vervloet, D | 1 |
| Caramori, G; Ciaccia, A; Cosma, P; Fabbri, L | 1 |
| Busse, WW; Jarjour, NN; McGill, K | 1 |
| Albertioni, F; Hedman, J; Seideman, P; Stenius-Aarniala, B | 1 |
| Barnes, PJ | 1 |
| Shiner, RJ; Shulimzon, TR | 1 |
| Brion, N; Paule, B | 1 |
| Chau, CH; Lee, J; Wong, CF; Wong, PC; Yew, WW | 1 |
| Spector, SL | 1 |
| Mullarkey, MF | 2 |
| Marin, MG | 1 |
| Banach-Wawrzeńczyk, E; Dziedziczko, A | 1 |
| Kazimierczak, A; Kuś, J; Maziarka, D; Skorupa, W | 1 |
| Alam, MN; Ali, ML; Baral, PK; Das, KK; Haq, SA | 1 |
| Aaron, SD; Dales, RE; Pham, B | 1 |
| Deykin, A; Israel, E | 1 |
| Bosque García, M; Comet Monte, R; Domingo Ribas, C; Montón Soler, C; Morón Besolí, A | 1 |
| Balfour-Lynn, I | 1 |
| Bridts, CH; De Clerck, LS; De Schutter, L; Schuerwegh, AJ; Stevens, WJ; Verbruggen, A | 1 |
| Droszcz, W; Rybus, L | 1 |
| Aalbers, R; Bron, A; Djukanovic, R; Holgate, ST; Shute, J; Vrugt, B; Wilson, S | 1 |
| Davies, H; Gibson, P; Olson, L | 1 |
| Holdaway, D; Lawrence, B; Raymond-Speden, E; Tripp, G | 1 |
| Legg, J; Warner, J | 1 |
| Goldreyer, B; Hanson, V; Singsen, B; Stanton, R | 1 |
| Wells, AU | 1 |
| Liang, TW; Tsai, JJ; Wang, SR | 1 |
| Cossart, C; Lavaud, F; Leone, J; Milosevic, D; Vallerand, H | 1 |
| Ito, K | 1 |
| Szefler, SJ | 1 |
| Delaney, SG; Taylor, DR | 1 |
| Cochran, JE; Cott, GR; Erzurum, SC; Glynn-Barnhart, AM; Leff, JA; Martin, RJ; Szefler, SJ | 1 |
| Alvarez, J; Szefler, SJ | 1 |
| Chung, KF; Geddes, DM; Shiner, RJ | 1 |
| Guss, S; Portnoy, J | 1 |
| Calderón, E; Coffey, RG; Lockey, RF | 1 |
| Geddes, DM | 1 |
| Harrison, AC; Kuitert, LM | 1 |
| Assadullahi, TP; Dagli, E; Warner, JO | 1 |
| Dyer, PD; Vaughan, TR; Weber, RW | 1 |
| Lammert, J; Mullarkey, MF; Stempel, DA | 1 |
| Knoblauch, A; Osterwalder, JJ | 1 |
| Chung, KF; Geddes, DM; Nunn, AJ; Shiner, RJ | 1 |
| Fertel, D; Wanner, A | 1 |
| Jones, G; Karsh, J; Mierins, E | 1 |
| Ackerson, LM; Cochran, JE; Cott, GR; Erzurum, SC; Leff, JA; Martin, RJ; Szefler, SJ | 1 |
| Falliers, CJ | 1 |
| Blumenstein, BA; Lammert, JK; Mullarkey, MF | 1 |
| Ward, MJ; White, JP | 1 |
| Kaslow, JE; Novey, HS | 1 |
| Andrade, WP; Bailey, GA; Blumenstein, BA; Mullarkey, MF; Olason, I; Wetzel, CE | 1 |
| Cherniack, RM; Cott, GR | 1 |
| Mullarkey, MF; Pardee, NE; Webb, DR | 1 |
| Filipp, G | 1 |
40 review(s) available for methotrexate and Asthma, Bronchial
| Article | Year |
|---|---|
Expert consensus on the systemic treatment of atopic dermatitis in special populations.
Topics: Aged; Asthma; Cyclosporine; Dermatitis, Atopic; Female; Humans; Methotrexate; Mycophenolic Acid | 2023 |
[Methotrexate may be a useful corticosteroid reducing treatment of severe asthma].
Topics: Adrenal Cortex Hormones; Asthma; Critical Pathways; Humans; Immunosuppressive Agents; Methotrexate; Severity of Illness Index | 2014 |
Managing severe asthma in adults: lessons from the ERS/ATS guidelines.
Topics: Adrenal Cortex Hormones; Adult; Anti-Asthmatic Agents; Asthma; Biomarkers; Comorbidity; Contraindications; Humans; Immunosuppressive Agents; Methotrexate; Nitric Oxide; Phenotype; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Risk Factors; Severity of Illness Index; Sputum | 2015 |
[Methotrexate may be a useful corticosteroid reducing treatment of severe asthma].
Topics: Adrenal Cortex Hormones; Asthma; Critical Pathways; Humans; Immunosuppressive Agents; Methotrexate; Severity of Illness Index | 2015 |
Relative risk of and determinants for adverse events of methotrexate prescribed at a low dose: a systematic review and meta-analysis of randomized placebo-controlled trials.
Topics: Anti-Asthmatic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Asthma; Dermatologic Agents; Female; Humans; Male; Methotrexate; Middle Aged; Psoriasis; Randomized Controlled Trials as Topic; Risk Factors | 2017 |
Therapeutic targets for persistent airway inflammation in refractory asthma.
Topics: Anti-Asthmatic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Asthma; Cyclosporine; Drug Delivery Systems; Drug Resistance; Etanercept; Gold Compounds; Humans; Immunoglobulin G; Inflammation; Leukotriene Antagonists; Methotrexate; Omalizumab; Phosphodiesterase Inhibitors; Receptors, Tumor Necrosis Factor; Respiration Disorders | 2010 |
Management of severe asthma in children.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Allergens; Anti-Asthmatic Agents; Asthma; Azathioprine; Bronchial Provocation Tests; Bronchodilator Agents; Budesonide; Budesonide, Formoterol Fumarate Drug Combination; Child; Clinical Trials as Topic; Comorbidity; Cyclosporine; Drug Combinations; Drug Resistance, Multiple; Drug Therapy, Combination; Eosinophils; Ethanolamines; Formoterol Fumarate; House Calls; Humans; Immunoglobulin E; Interdisciplinary Communication; Methotrexate; Off-Label Use; Risk Factors; Severity of Illness Index; Spirometry; Terbutaline; Tobacco Smoke Pollution; Tomography, X-Ray Computed; Treatment Outcome | 2010 |
Rationale for the use of immunomodulatory therapies in the Global Initiative for Asthma (GINA) step V asthma other than oral glucocorticosteroids.
Topics: Administration, Oral; Adrenal Cortex Hormones; Anti-Asthmatic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humanized; Asthma; Controlled Clinical Trials as Topic; Global Health; Humans; Immunomodulation; Methotrexate; Omalizumab | 2011 |
Alternate treatments in asthma.
Topics: Anti-Asthmatic Agents; Anticoagulants; Asthma; Cyclosporine; Diuretics; Folic Acid Antagonists; Furosemide; Gold; Heparin; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Methotrexate; T-Lymphocytes; Troleandomycin | 2003 |
Novel immunosuppressants in asthma.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Asthma; CD4 Antigens; Cross-Over Studies; Cyclosporine; Double-Blind Method; Humans; Immunosuppressive Agents; Methotrexate; Models, Immunological; Organogold Compounds; Randomized Controlled Trials as Topic; Sirolimus; Tacrolimus | 2000 |
Recent progress in the pharmacotherapy of Churg-Strauss syndrome.
Topics: Adrenal Cortex Hormones; Angiogenesis Inhibitors; Anti-Asthmatic Agents; Asthma; Churg-Strauss Syndrome; Cyclophosphamide; Humans; Immunosuppressive Agents; Interferon-alpha; Methotrexate; Plasmapheresis | 2004 |
[Therapy-resistant asthma--a distinct phenotype?].
Topics: Adrenal Cortex Hormones; Asthma; Controlled Clinical Trials as Topic; Diagnosis, Differential; Drug Resistance; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Patient Compliance; Phenotype; Physician-Patient Relations; Risk Factors; Sex Factors; Smoking; Socioeconomic Factors; Tumor Necrosis Factor-alpha | 2006 |
Corticosteroid sparing agents in asthma.
Topics: Adrenal Cortex Hormones; Asthma; Cyclosporine; Gold; Humans; Hydroxychloroquine; Methotrexate | 1995 |
[Methotrexate therapy of inflammatory diseases. Reliable effects and recent developments in rheumatology, pneumology, gastroenterology and dermatology].
Topics: Asthma; Clinical Trials as Topic; Humans; Inflammatory Bowel Diseases; Methotrexate; Psoriasis; Rheumatic Diseases | 1995 |
[Methotrexate treatment of patients with prednisolone dependent bronchial asthma].
Topics: Asthma; Drug Therapy, Combination; Humans; Methotrexate; Prednisolone | 1995 |
Alternative pharmacotherapies for steroid-dependent asthma.
Topics: Adrenal Cortex Hormones; Asthma; Clinical Trials as Topic; Cyclosporine; Dapsone; Furosemide; Gold; Humans; Hydroxychloroquine; Magnesium Sulfate; Methotrexate; Treatment Outcome; Troleandomycin | 1995 |
Advances in respiratory therapeutics in children.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Bronchiolitis, Viral; Bronchodilator Agents; Budesonide; Child; Cystic Fibrosis; Hemosiderosis; Humans; Infant, Newborn; Lung Diseases; Methotrexate; Pregnenediones; Pulmonary Surfactants; Respiratory Distress Syndrome, Newborn; Theophylline | 1993 |
Methotrexate in the treatment of severe asthma.
Topics: Asthma; Humans; Methotrexate | 1993 |
Methotrexate in asthma. A safety perspective.
Topics: Asthma; Humans; Methotrexate | 1993 |
Methotrexate for the treatment of chronic corticosteroid-dependent asthma.
Topics: Adrenal Cortex Hormones; Asthma; Chronic Disease; Clinical Trials as Topic; Drug Interactions; Humans; Methotrexate | 1993 |
Methotrexate in the management of severe steroid dependent asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Prednisone; Severity of Illness Index; Treatment Outcome | 1993 |
[Treatment of chronic persistent severe asthma: role of methotrexate].
Topics: Adrenal Cortex Hormones; Asthma; Chronic Disease; Clinical Protocols; Humans; Methotrexate; Severity of Illness Index | 1993 |
Methotrexate in the treatment of systemic glucocorticoid-dependent severe persistent asthma: a word of caution.
Topics: Asthma; Clinical Trials as Topic; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrexate | 1996 |
Current management of asthma patients with corticosteroid resistance.
Topics: Anti-Inflammatory Agents; Asthma; Cyclosporine; Drug Resistance; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Methotrexate; Steroids | 1996 |
Immunomodulation as asthma therapy: where do we stand?
Topics: Adjuvants, Immunologic; Administration, Inhalation; Adrenal Cortex Hormones; Anti-Asthmatic Agents; Anti-Bacterial Agents; Antibodies, Monoclonal; Asthma; Bronchodilator Agents; Cell Adhesion; Cromolyn Sodium; Cyclosporine; Cytokines; Gold; Humans; Immunoglobulin G; Immunosuppressive Agents; Macrolides; Methotrexate; Nedocromil; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Theophylline | 1996 |
A risk-benefit assessment of methotrexate in corticosteroid-dependent asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Asthma; Child; Child, Preschool; Dose-Response Relationship, Drug; Folic Acid Antagonists; Follow-Up Studies; Humans; Liver; Lung; Methotrexate; Randomized Controlled Trials as Topic; Risk Assessment | 1996 |
[Non-cancer uses of methotrexate].
Topics: Adult; Aged; Anti-Asthmatic Agents; Antirheumatic Agents; Arthritis, Juvenile; Arthritis, Rheumatoid; Asthma; Child; Contraindications; Dermatologic Agents; Drug Tolerance; Humans; Methotrexate; Psoriasis | 1996 |
Alternative treatments in the patient with intractable asthma.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Infective Agents; Antirheumatic Agents; Asthma; Cyclosporine; Dapsone; Humans; Hydroxychloroquine; Immunization, Passive; Immunosuppressive Agents; Methotrexate; Organogold Compounds; SRS-A; Troleandomycin | 1997 |
Low-dose methotrexate spares steroid usage in steroid-dependent asthmatic patients: a meta-analysis.
Topics: Adult; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Prednisolone; Prednisone | 1997 |
[Pneumocystis pneumonia in patients with steroid-dependent asthma].
Topics: Adrenal Cortex Hormones; Asthma; Humans; Immunocompetence; Methotrexate; Pneumonia, Pneumocystis | 1997 |
Management of steroid-dependent asthma with methotrexate: a meta-analysis of randomized clinical trials.
Topics: Asthma; Drug Administration Schedule; Drug Therapy, Combination; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrexate; Prednisone; Randomized Controlled Trials as Topic | 1998 |
Newer therapeutic agents for asthma.
Topics: Adrenergic beta-Agonists; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Cyclosporine; Fluticasone; Forced Expiratory Volume; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Indoles; Leukotriene Antagonists; Lidocaine; Methotrexate; Phenylcarbamates; Salmeterol Xinafoate; Sulfonamides; Tosyl Compounds; Treatment Outcome | 1999 |
Difficult asthma: beyond the guidelines.
Topics: Asthma; Budesonide; Child; Chronic Disease; Cyclosporine; Drug Administration Routes; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Leukotriene Antagonists; Methotrexate; Patient Compliance; Patient Education as Topic; Terbutaline; Treatment Failure | 1999 |
Methotrexate as a steroid sparing agent for asthma in adults.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Asthma; Drug Therapy, Combination; Humans; Methotrexate; Substance-Related Disorders | 2000 |
Asthma--the changing face of drug therapy.
Topics: Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Child; Cyclosporine; Enzyme Inhibitors; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Leukotriene Antagonists; Methotrexate; Phosphodiesterase Inhibitors | 2000 |
Anti-inflammatory drugs in the treatment of allergic disease.
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Auranofin; Bronchodilator Agents; Cromolyn Sodium; Drug Therapy, Combination; Glucocorticoids; Humans; Hydroxychloroquine; Immunoglobulins, Intravenous; Methotrexate; Quality of Life; Severity of Illness Index; Steroids; Theophylline; Troleandomycin | 1992 |
Steroid-sparing agents in the treatment of asthma.
Topics: Asthma; Gold; Humans; Methotrexate; Troleandomycin | 1992 |
Alternative therapy in severe asthma.
Topics: Anti-Inflammatory Agents; Asthma; Auranofin; Gold; Humans; Immunoglobulins, Intravenous; Methotrexate; Troleandomycin | 1992 |
Methotrexate in asthma.
Topics: Asthma; Drug Therapy, Combination; Humans; Methotrexate; Prednisolone | 1991 |
Drug-induced adverse pulmonary reactions.
Topics: Amiodarone; Asthma; Bleomycin; Carmustine; Drug-Related Side Effects and Adverse Reactions; Gold; Humans; Hydrochlorothiazide; Hypertension, Pulmonary; Lung Diseases; Lupus Erythematosus, Systemic; Lymphatic Diseases; Mediastinum; Methotrexate; Nitrofurantoin; Penicillamine; Pleural Effusion; Pulmonary Edema; Pulmonary Eosinophilia; Pulmonary Fibrosis; Ritodrine | 1985 |
26 trial(s) available for methotrexate and Asthma, Bronchial
| Article | Year |
|---|---|
Weekly low-dose methotrexate for reduction of Global Initiative for Asthma Step 5 treatment in severe refractory asthma: study protocol for a randomized controlled trial.
Topics: Anti-Asthmatic Agents; Asthma; Chronic Disease; Clinical Protocols; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Italy; Methotrexate; Research Design; Severity of Illness Index; Tertiary Care Centers; Time Factors; Treatment Outcome | 2014 |
A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis.
Topics: Adrenergic beta-Antagonists; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimanic Agents; Asthma; Community Pharmacy Services; Contraceptives, Oral, Hormonal; Contraindications; Cost-Benefit Analysis; Drug Information Services; Drug Monitoring; Electrolytes; England; Family Practice; Feedback, Psychological; Humans; Immunosuppressive Agents; Lithium Compounds; Medication Errors; Methotrexate; Peptic Ulcer; Pharmacists; Proton Pump Inhibitors; Regression Analysis; Sodium Potassium Chloride Symporter Inhibitors; Urea | 2012 |
Benefits of low weekly doses of methotrexate in steroid-dependent asthmatic patients. A double-blind, randomized, placebo-controlled study.
Topics: Adult; Aged; Asthma; Bone and Bones; Bronchodilator Agents; Double-Blind Method; Drug Administration Schedule; Female; Glucocorticoids; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Respiratory Function Tests; Steroids | 2006 |
Short term effect of methotrexate in severe steroid-dependent asthma.
Topics: Administration, Oral; Adult; Aged; Anti-Asthmatic Agents; Asthma; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Peak Expiratory Flow Rate; Prednisone | 1995 |
Single, high-dose intramuscular triamcinolone acetonide versus weekly oral methotrexate in life-threatening asthma: a double-blind study.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Analysis of Variance; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged; Time Factors; Triamcinolone Acetonide | 1995 |
[Methotrexate treatment of patients with prednisolone dependent bronchial asthma].
Topics: Asthma; Drug Therapy, Combination; Humans; Methotrexate; Prednisolone | 1995 |
Methotrexate in steroid-dependent asthma: long-term results.
Topics: Adult; Aged; Asthma; Beclomethasone; Bronchodilator Agents; Budesonide; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged; Prednisone; Pregnenediones; Prospective Studies; Time Factors; Treatment Outcome | 1994 |
[Methotrexate in the treatment of asthma. Open trial in 10 corticoid-dependent patients with severe asthma].
Topics: Adrenal Cortex Hormones; Adult; Asthma; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Male; Methotrexate; Middle Aged; Prednisone; Prospective Studies; Spirometry; Substance-Related Disorders; Time Factors | 1994 |
The role of methotrexate in the management of steroid-dependent asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Double-Blind Method; Forced Expiratory Volume; Humans; Lung; Methotrexate; Middle Aged; Peak Expiratory Flow Rate; Placebos; Prednisone; Prospective Studies; Pulmonary Ventilation; Spirometry; Theophylline; Vital Capacity | 1994 |
Comparison of oral pulse methotrexate with placebo in the treatment of severe glucocorticosteroid-dependent asthma.
Topics: Administration, Oral; Adult; Aged; Asthma; Chronic Disease; Double-Blind Method; Drug Tolerance; Female; Forced Expiratory Volume; Humans; Lung; Male; Methotrexate; Middle Aged; Placebos; Prednisone; Theophylline | 1994 |
Methotrexate in the management of severe steroid dependent asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged; Prednisone; Severity of Illness Index; Treatment Outcome | 1993 |
Comparison of methotrexate 30 mg per week with placebo in chronic steroid-dependent asthma: a 12-week double-blind, cross-over study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Asthma; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone | 1993 |
Single, high dose intramuscular triamcinolone acetonide versus weekly oral methotrexate in life-threatening asthma: a double blind study.
Topics: Administration, Oral; Anti-Asthmatic Agents; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Glucocorticoids; Humans; Injections, Intramuscular; Methotrexate; Therapeutic Equivalency; Triamcinolone Acetonide | 1996 |
Controlled trial of methotrexate in patients with severe chronic asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aerosols; Analysis of Variance; Anti-Inflammatory Agents; Asthma; Beclomethasone; Bronchodilator Agents; Budesonide; Cross-Over Studies; Double-Blind Method; Female; Folic Acid Antagonists; Forced Expiratory Volume; Humans; Male; Methotrexate; Middle Aged; Peak Expiratory Flow Rate; Pregnenediones | 1996 |
Low-dose methotrexate in the management of Chinese patients with steroid-dependent asthma.
Topics: Adult; Aged; Asthma; Chemical and Drug Induced Liver Injury; China; Hong Kong; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Respiratory Function Tests | 1996 |
[Use of methotrexate for treatment of corticosteroid-dependent asthma].
Topics: Administration, Oral; Adult; Aged; Asthma; Drug Administration Schedule; Female; Folic Acid Antagonists; Glucocorticoids; Humans; Male; Methotrexate; Middle Aged; Prednisone | 1997 |
Efficacy of methotrexate in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Asthma; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Remission Induction | 1997 |
[Efficiency of methotrexate in the treatment of cortico-dependent asthmatic patients].
Topics: Adolescent; Adult; Aged; Asthma; Female; Forced Expiratory Volume; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Methylprednisolone; Middle Aged; Prospective Studies | 1999 |
[The role of methotrexate in the management of severe steroid-dependent asthma].
Topics: Adult; Aged; Anti-Inflammatory Agents; Asthma; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Steroids; Treatment Outcome | 1999 |
Steroid-sparing agents in the treatment of asthma.
Topics: Asthma; Gold; Humans; Methotrexate; Troleandomycin | 1992 |
Methotrexate in the treatment of steroid-dependent asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Asthma; Double-Blind Method; Female; Humans; Male; Methotrexate; Middle Aged | 1991 |
[Randomized and controlled single-case study--a scientific method for individual and difficult therapy decisions in clinical practice exemplified with methotrexate use in asthma].
Topics: Adult; Asthma; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Methotrexate; Prednisone; Theophylline | 1991 |
Randomised, double-blind, placebo-controlled trial of methotrexate in steroid-dependent asthma.
Topics: Administration, Oral; Adult; Aged; Asthma; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Female; Humans; Liver Function Tests; Male; Methotrexate; Middle Aged; Peak Expiratory Flow Rate; Prednisone; Randomized Controlled Trials as Topic; Severity of Illness Index; Time Factors | 1990 |
Lack of benefit of methotrexate in severe, steroid-dependent asthma. A double-blind, placebo-controlled study.
Topics: Adrenal Cortex Hormones; Adult; Asthma; Bronchodilator Agents; Double-Blind Method; Eosinophils; Humans; Immunoglobulin E; Methotrexate; Middle Aged; Placebos; Prospective Studies; Respiratory Function Tests; Statistics as Topic | 1991 |
Steroids and "steroid-sparing" agents in asthma.
Topics: Adrenal Cortex Hormones; Asthma; Clinical Trials as Topic; Double-Blind Method; Humans; Methotrexate; Substance-Related Disorders | 1988 |
Methotrexate in the treatment of corticosteroid-dependent asthma. A double-blind crossover study.
Topics: Adrenal Cortex Hormones; Adult; Aged; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Male; Methotrexate; Middle Aged; Prednisone; Vital Capacity | 1988 |
52 other study(ies) available for methotrexate and Asthma, Bronchial
| Article | Year |
|---|---|
A case of chronic eosinophilic pneumonia associated with rheumatoid arthritis in glucocorticoid-free remission with JAK inhibitor: A case report.
Topics: Adult; Arthritis, Rheumatoid; Asthma; Female; Glucocorticoids; Humans; Janus Kinase Inhibitors; Methotrexate; Middle Aged; Prednisolone; Pulmonary Eosinophilia; Recurrence; Young Adult | 2023 |
Periocular xanthogranuloma with adult-onset asthma: a rare disorder associated with elevated IgG4 levels.
Topics: Aged; Asthma; Dermatologic Agents; Eye Diseases; Humans; Immunoglobulin G; Male; Methotrexate; Necrobiotic Xanthogranuloma; Poland; Rare Diseases; Treatment Outcome | 2019 |
The role of oral methotrexate as a steroid sparing agent in refractory eosinophilic asthma.
Topics: Adrenal Cortex Hormones; Adult; Aged; Asthma; Deprescriptions; Eosinophilia; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Tertiary Care Centers; Treatment Outcome | 2018 |
Clinically relevant pharmacogenomic testing in pediatric practice.
Topics: Antidepressive Agents; Asthma; Child; Codeine; Cytochrome P-450 CYP2D6; Humans; Immunologic Factors; Mercaptopurine; Methotrexate; Pediatrics; Pharmacogenetics; Polymorphism, Single Nucleotide; Tacrolimus | 2014 |
Adult-onset asthma and periocular xanthogranuloma: A rare case report.
Topics: Asthma; Combined Modality Therapy; Eyelid Diseases; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Necrobiotic Xanthogranuloma; Ophthalmologic Surgical Procedures; Tomography, Optical Coherence | 2016 |
Golimumab, a fully human monoclonal antibody against TNFalpha.
Topics: Adult; Animals; Antibodies, Monoclonal; Arthritis, Rheumatoid; Asthma; Clinical Trials as Topic; Colitis, Ulcerative; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Spondylitis, Ankylosing; Tumor Necrosis Factor-alpha | 2008 |
Twelve years' experience with methotrexate for GINA treatment step 5 asthma patients.
Topics: Adult; Aged; Asthma; Female; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prospective Studies; Respiratory Function Tests | 2009 |
Methotrexate: can it be a choice for nasal polyposis in aspirin exacerbated respiratory disease?
Topics: Adrenal Cortex Hormones; Aged; Aspirin; Asthma; Drug Hypersensitivity; Endoscopy; Female; Forced Expiratory Volume; Humans; Methotrexate; Methylprednisolone; Middle Aged; Nasal Cavity; Nasal Polyps; Paranasal Sinuses; Tomography, X-Ray Computed | 2009 |
Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis and bronchial asthma: a case report.
Topics: Aged; Albendazole; Animals; Antinematodal Agents; Arthritis, Rheumatoid; Asthma; Drug Therapy, Combination; Female; Humans; Immunocompromised Host; Intestinal Diseases, Parasitic; Ivermectin; Methotrexate; Opportunistic Infections; Pregnenediones; Soil; Strongyloides stercoralis; Strongyloidiasis | 2010 |
Transient monocular vision loss due to churg-strauss syndrome vasculitis.
Topics: Asthma; Biopsy; Blindness; Blood Sedimentation; C-Reactive Protein; Churg-Strauss Syndrome; Glucocorticoids; Humans; Immunosuppressive Agents; Leukocyte Count; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Prednisone; Pulmonary Atelectasis; Temporal Arteries; Tomography, X-Ray Computed; Vision, Monocular | 2013 |
Methotrexate therapy in asthma increases T cell susceptibility to corticosteroid inhibition.
Topics: Adult; Aged; Anti-Inflammatory Agents; Asthma; Cells, Cultured; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Glucocorticoids; Humans; Immunosuppressive Agents; Lymphocyte Activation; Methotrexate; Middle Aged; Phytohemagglutinins; Prednisolone; T-Lymphocytes | 2003 |
The effect of the steroid-sparing response to low-dose methotrexate on bone metabolism in glucocorticoid-dependent asthmatics.
Topics: Adult; Aged; Alkaline Phosphatase; Amino Acids; Anti-Inflammatory Agents; Asthma; Biomarkers; Bone and Bones; Clinical Trials as Topic; Collagen Type I; Creatinine; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Osteocalcin; Prednisolone; Retrospective Studies | 2004 |
Methotrexate therapy of oral corticosteroid-dependent asthmatics reduces serum immunoglobulins: correlation with clinical response to therapy.
Topics: Administration, Oral; Adult; Asthma; Drug Administration Schedule; Drug Therapy, Combination; Forced Expiratory Volume; Humans; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunosuppressive Agents; Injections, Intramuscular; Leukocyte Count; Methotrexate; Prednisolone; Treatment Outcome | 2005 |
Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Asthma; Autoimmune Diseases; Drug Synergism; Gene Expression Regulation; Humans; Immunosuppressive Agents; Inflammation; Jurkat Cells; Lipopolysaccharides; Lymphocytes; Methotrexate; Protein Isoforms; Receptors, Glucocorticoid; Theobromine; Vasodilator Agents | 2007 |
Bronchial asthma and acute lymphoblastic leukemia in childhood.
Topics: Acute Disease; Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Asthma; Drug Administration Schedule; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
Long-term treatment with methotrexate in patients with corticosteroid-dependent bronchial asthma.
Topics: Adult; Asthma; Female; Forced Expiratory Volume; Humans; Longitudinal Studies; Male; Methotrexate; Middle Aged; Oxygen; Prednisolone; Pulmonary Diffusing Capacity; Spirometry; Transaminases; Vital Capacity | 1995 |
[Methotrexate in the treatment of asthma. An inappropriate emergency solution or a valuable experimental treatment?].
Topics: Asthma; Clinical Trials as Topic; Evaluation Studies as Topic; Humans; Methotrexate | 1995 |
Effect of methotrexate on asthmatic reaction in sensitized guinea pigs.
Topics: Airway Resistance; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Eosinophils; Guinea Pigs; Immunization; Lung; Male; Methotrexate; Respiratory System; Time Factors | 1995 |
Fatal chickenpox pneumonia in an asthmatic patient on oral steroids and methotrexate.
Topics: Acyclovir; Asthma; Chickenpox; Fatal Outcome; Humans; Immunosuppression Therapy; Male; Methotrexate; Middle Aged; Pneumonia, Viral; Radiography | 1995 |
The inhibitory effect of methotrexate on PAF-induced neutrophil and eosinophil locomotion in asthmatic patients.
Topics: Asthma; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Eosinophils; Humans; Leukocytes, Mononuclear; Leukotriene B4; Methotrexate; Neutrophils; Platelet Activating Factor | 1994 |
[Studies on biphasic animal model of asthma--lymphocytes and eosinophils].
Topics: Animals; Asthma; Disease Models, Animal; Eosinophils; Guinea Pigs; Lung; Lymphocytes; Methotrexate | 1993 |
Methotrexate and asthma.
Topics: Arthritis, Rheumatoid; Asthma; Female; Humans; Methotrexate; Middle Aged | 1993 |
Perspectives on methotrexate in the treatment of asthma.
Topics: Asthma; Double-Blind Method; Humans; Methotrexate; Randomized Controlled Trials as Topic; Treatment Outcome | 1994 |
Methotrexate in asthma--an alternative view.
Topics: Asthma; Drug Therapy, Combination; Humans; Methotrexate; Prednisone | 1993 |
Methotrexate pneumonitis in bronchial asthma.
Topics: Asthma; Humans; Male; Methotrexate; Middle Aged; Pneumonia | 1993 |
Fatal varicella zoster infection in a severe steroid dependent asthmatic patient receiving methotrexate.
Topics: Adult; Asthma; Chickenpox; Disseminated Intravascular Coagulation; Fatal Outcome; Humans; Immunosuppressive Agents; Male; Methotrexate; Prednisolone | 1995 |
Methotrexate revisited.
Topics: Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Humans; Immunosuppressive Agents; Methotrexate; Prednisone; Time Factors | 1997 |
Flow cytometric detection of type 1 (IL-2, IFN-gamma) and type 2 (IL-4, IL-5) cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid arthritis, allergic asthma and atopic dermatitis.
Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Asthma; CD8-Positive T-Lymphocytes; Cytokines; Dermatitis, Atopic; Flow Cytometry; Humans; Interferon-gamma; Interleukin-2; Interleukin-4; Interleukin-5; Lymphocyte Count; Methotrexate; Middle Aged; T-Lymphocytes, Helper-Inducer | 1999 |
Low-dose methotrexate treatment in severe glucocorticoid-dependent asthma: effect on mucosal inflammation and in vitro sensitivity to glucocorticoids of mitogen-induced T-cell proliferation.
Topics: Adolescent; Adult; Asthma; Cell Division; Dexamethasone; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Respiratory Mucosa; Severity of Illness Index; T-Lymphocytes | 2000 |
Intellectual, neuropsychological, and academic functioning in long-term survivors of leukemia.
Topics: Achievement; Adolescent; Antineoplastic Agents; Asthma; Brain; Child; Chronic Disease; Cognition Disorders; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Injections, Spinal; Intelligence; Intelligence Tests; Long-Term Care; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Severity of Illness Index; Survivors | 2000 |
Childhood polymyositis with cardiac conduction defects.
Topics: Arrhythmias, Cardiac; Asthma; Child; Child, Preschool; Electrocardiography; Female; Humans; Methotrexate; Myositis; Prednisolone | 1976 |
Corticosteroid induced osteoporosis in severe menstrual asthma. Steroid sparing drugs may be useful.
Topics: Adult; Asthma; Female; Humans; Menstruation Disturbances; Methotrexate; Osteoporosis; Prednisolone | 1992 |
[Long term and low dose treatment with methotrexate in corticosteroid-dependent asthma--two-year clinical experience].
Topics: Adult; Aged; Asthma; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Middle Aged; Prednisolone | 1992 |
Fatal pneumocystis pneumonia in asthmatic patient treated with methotrexate.
Topics: Asthma; Humans; Male; Methotrexate; Middle Aged; Pneumonia, Pneumocystis | 1992 |
[Current concept on therapy of asthma and pollenosis].
Topics: Adrenergic beta-Agonists; Allergens; Animals; Asthma; Bronchial Provocation Tests; Desensitization, Immunologic; Humans; Methotrexate; Mites; Parasympatholytics; Pollen; Rhinitis, Allergic, Seasonal; Theophylline | 1992 |
Pharmacokinetics of low-dose methotrexate in adult asthmatics.
Topics: Adolescent; Adult; Aged; Asthma; Drug Administration Schedule; Female; Half-Life; Humans; Injections, Intramuscular; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Theophylline | 1992 |
Methotrexate: does it treat or induce asthma?
Topics: Asthma; Humans; Methotrexate | 1992 |
Methotrexate treatment of severe asthma in children.
Topics: Adolescent; Albuterol; Asthma; Beclomethasone; Body Height; Body Weight; Child; Child, Preschool; Cromolyn Sodium; Female; Forced Expiratory Volume; Humans; Male; Maximal Expiratory Flow Rate; Methotrexate; Prednisone; Spirometry; Theophylline; Vital Capacity | 1992 |
Methotrexate in bronchial asthma.
Topics: Asthma; Basophils; Chemotaxis, Leukocyte; Histamine Release; Humans; Interleukin-1; Methotrexate; Neutrophils | 1991 |
Pneumocystis carinii pneumonia as a complication of methotrexate treatment of asthma.
Topics: Adult; Asthma; Humans; Immunosuppression Therapy; Male; Methotrexate; Opportunistic Infections; Pneumonia, Pneumocystis | 1991 |
High-performance liquid chromatography method for serum methotrexate levels in children with severe steroid-dependent asthma.
Topics: Administration, Oral; Adolescent; Asthma; Calibration; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Methotrexate; Steroids | 1991 |
Methotrexate and asthma.
Topics: Adrenal Cortex Hormones; Asthma; Humans; Methotrexate | 1991 |
Use of methotrexate in the treatment of steroid-dependent adolescent asthmatics.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Child; Female; Humans; Male; Methotrexate; Methylprednisolone; Prednisone; Steroids | 1991 |
Methotrexate: does it treat or induce asthma?
Topics: Asthma; Humans; Lung; Methotrexate | 1991 |
Methotrexate-induced asthma.
Topics: Asthma; Bronchial Provocation Tests; Female; Humans; Methacholine Chloride; Methotrexate; Middle Aged | 1991 |
Cancer chemotherapy: hormonal changes and recurring asthma.
Topics: Adenocarcinoma; Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Asthma; Breast Neoplasms; Cyclophosphamide; Drug Hypersensitivity; Female; Fluorouracil; Humans; Methotrexate; Recurrence | 1991 |
Methotrexate for asthma.
Topics: Asthma; Humans; Methotrexate | 1991 |
Long-term methotrexate treatment in corticosteroid-dependent asthma.
Topics: Adult; Aged; Asthma; Drug Administration Schedule; Drug Therapy, Combination; Female; Forced Expiratory Volume; Humans; Male; Methotrexate; Middle Aged; Prednisolone; Prospective Studies | 1990 |
Methotrexate use for asthma: a critical appraisal.
Topics: Asthma; Drug Interactions; Folic Acid Antagonists; Humans; Methotrexate | 1989 |
Steroids and "steroid-sparing" agents in asthma.
Topics: Adrenal Cortex Hormones; Asthma; Drug Therapy, Combination; Humans; Methotrexate | 1988 |
Methotrexate in the treatment of steroid-dependent asthma.
Topics: Asthma; Female; Glucocorticoids; Humans; Methotrexate; Middle Aged; Prednisone; Statistics as Topic | 1986 |
Is specific desensitization due to specific blocking antibodies or due to an immunological tolerance? New experiments on this problem.
Topics: Adrenal Cortex Hormones; Animals; Antibodies; Antibody Formation; Antigen-Antibody Complex; Antigens; Asthma; Autoradiography; Azathioprine; Desensitization, Immunologic; gamma-Globulins; Guinea Pigs; Horses; Humans; Immune Tolerance; Iodine Radioisotopes; Methotrexate; Pollen; Rhinitis, Allergic, Seasonal; Whooping Cough | 1972 |