methotrexate has been researched along with Aging in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (44.19) | 18.7374 |
| 1990's | 13 (30.23) | 18.2507 |
| 2000's | 5 (11.63) | 29.6817 |
| 2010's | 6 (13.95) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Accardi, G; Aiello, A | 1 |
| Abdo, M; Fekry, E; Makary, S | 1 |
| Frandsen, TL; Grell, K; Hjalgrim, LL; Nersting, J; Nielsen, SN; Schmiegelow, K | 1 |
| Cool, JC; Fan, C; Foster, BK; Scherer, MA; Shandala, T; Tapp, H; Xian, CJ | 1 |
| Mortimer, J; Pal, SK | 1 |
| Boos, J; Frühwald, MC; Gerss, J; Hempel, G; Mühlisch, J; Niemann, A | 1 |
| Bessell, EM; Dickinson, P; Dickinson, S; Salmon, J | 1 |
| Gonzalez-Aguilar, A; Hoang-Xuan, K; Houillier, C; Soussain, C | 1 |
| Drosos, A | 1 |
| GOLDGRABER, MB; KIRSNER, JB | 1 |
| BISHOP, RC; HINES, DR; MEYERS, MC | 1 |
| Aapro, M; Biganzoli, L; Castiglione-Gertsch, M; Goldhirsch, A; Minisini, A; Piccart, MJ; Straehle, C; Therasse, P | 1 |
| Furst, DE; Ranganath, VK | 1 |
| Bartram, CR; Mortier, W; Reinhardt, D; Serwinski, J | 1 |
| Gelman, RS; Taylor, SG | 1 |
| Barak, AJ; Kemmy, RJ | 1 |
| Amadori, S; Baccarani, M; Cardozo, PL; Corbelli, G; Drenthe-Schonk, A; Haanen, C; Mandelli, F; Meloni, G; Tura, S; Willemze, R | 1 |
| Hess, CE; Zirkle, JW | 1 |
| Leeb, BF | 1 |
| Furst, DE; Gardner, G | 1 |
| Bregliano, JC; Degroote, F; Laurençon, A | 1 |
| Chabner, BA; Treon, SP | 1 |
| Tett, SE; Triggs, EJ | 1 |
| Arcos, B; Bologna, C; Bressolle, F; Combe, B; Kinowski, JM; Sany, J | 1 |
| Aota, S; Inoue, N; Itokazu, Y; Nakamura, T; Okazaki, Y; Omata, T; Segawa, Y; Tsuzuike, N | 1 |
| Auclerc, MF; Holland, JF; Jacquillat, C; Schaison, G; Weil, M | 1 |
| Perez, C; Romsdahl, MM; Sutow, WW; Wang, YM | 1 |
| Dabrowski, MP; Goldstein, AL | 1 |
| Hutters, L; Kristensen, LO; Weismann, K | 1 |
| Howells, DW; Hyland, K; Smith, I; Strobel, S | 1 |
| Raghavan, D | 1 |
| Lanning, M; Myllylä, V; Risteli, J; Risteli, L; Vainionpää, L | 1 |
| Cathey, MA; Wolfe, F | 1 |
| Borsi, JD; Moe, PJ; Romslo, I; Sagen, E; Slørdal, L | 1 |
| Kyner, D; Rothenberg, SP | 1 |
| Dicke, KA; Weiner, RS | 1 |
| Freund, M; Oellerich, M; Poliwoda, H; Raude, E; Riehm, H; Schrappe, M; Weinel, P | 1 |
| Hönigsmann, H; Ortel, B; Tanew, A; Wolff, K; Zussner, C | 1 |
| Neilan, BA | 1 |
| Bodansky, O; Nisselbaum, JS; Schwartz, MK | 1 |
| Mikami, M; Murakami, K; Tsunoda, T; Ueda, Y; Yamamoto, M | 1 |
9 review(s) available for methotrexate and Aging
| Article | Year |
|---|---|
Adjuvant chemotherapy for older adults with breast cancer: making the standard a standard.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Confidence Intervals; Deoxycytidine; Doxorubicin; Female; Fluorouracil; Humans; Methotrexate; Proportional Hazards Models; Risk Assessment; Risk Factors | 2009 |
[Management of primary central nervous system lymphoma].
Topics: Adult; Aged; Aging; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Lymphoma; Methotrexate; Prognosis | 2011 |
Methotrexate intolerance in elderly patients with rheumatoid arthritis: what are the alternatives?
Topics: Aged; Aging; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug Tolerance; Humans; Metabolic Diseases; Methotrexate | 2003 |
Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient.
Topics: Aged; Aging; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Glomerular Filtration Rate; Humans; Isoxazoles; Leflunomide; Methotrexate; Sulfasalazine | 2007 |
Should folate supplementation be routinely recommended for older patients receiving methotrexate?
Topics: Aging; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Geriatric Assessment; Humans; Leucovorin; Methotrexate | 1994 |
Disease-modifying antirheumatic drugs. Potential effects in older patients.
Topics: Aged; Aging; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Sulfasalazine | 1995 |
Concepts in use of high-dose methotrexate therapy.
Topics: Adult; Aging; Animals; Antimetabolites, Antineoplastic; Bone Marrow Diseases; Child; Drug Monitoring; Humans; Methotrexate; Middle Aged; Neoplasms | 1996 |
Management of advanced bladder cancer in the elderly.
Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cystectomy; Doxorubicin; Humans; Methotrexate; Urinary Bladder Neoplasms; Vinblastine | 1992 |
Isozymes of aspartate aminotransferase in tissues and blood of man.
Topics: Acute Disease; Adult; Aging; Alpha-Globulins; Animals; Aspartate Aminotransferases; Aspartic Acid; Beta-Globulins; Cattle; Choriocarcinoma; Cytoplasm; Dogs; Electrophoresis; Erythrocytes; Female; gamma-Globulins; Gluconeogenesis; Humans; Hydrogen-Ion Concentration; Immune Sera; Immunochemistry; In Vitro Techniques; Isoenzymes; Ketoglutaric Acids; Kinetics; Liver; Methotrexate; Mitochondria; Myocardium; Neoplasms; Organ Specificity; Phenylhydrazines; Pregnancy; Rabbits; Rats; Reticulocytes; Starch | 1966 |
1 trial(s) available for methotrexate and Aging
| Article | Year |
|---|---|
The effect of age and renal function on the efficacy and toxicity of methotrexate in rheumatoid arthritis. Rheumatoid Arthritis Clinical Trial Archive Group.
Topics: Aged; Aging; Arthritis, Rheumatoid; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Methotrexate; Middle Aged; Odds Ratio | 1995 |
33 other study(ies) available for methotrexate and Aging
| Article | Year |
|---|---|
Aging Successfully: The Role of Genetics and Environment in the Era of the Aging-Boom. Potential Therapeutic Implications.
Topics: Aging; Epigenesis, Genetic; Eye Diseases; Humans; Immune System; Longevity; Melatonin; Methotrexate; MicroRNAs; Toll-Like Receptors; Vaccination | 2019 |
Oxidative stress burden inhibits spermatogenesis in adult male rats: testosterone protective effect.
Topics: Aging; Animals; Biomarkers; Body Weight; Estradiol; Follicle Stimulating Hormone; Grape Seed Extract; Inflammation; Letrozole; Male; Methotrexate; Nitriles; Organ Size; Oxidative Stress; Protective Agents; Rats, Sprague-Dawley; Seminiferous Tubules; Sperm Count; Sperm Motility; Spermatogenesis; Testosterone; Triazoles | 2018 |
Measures of 6-mercaptopurine and methotrexate maintenance therapy intensity in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Aging; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Child; Child, Preschool; Female; Genotype; Humans; Leukocyte Count; Leukopenia; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; PTEN Phosphohydrolase; Risk Assessment | 2016 |
Damaging effects of chronic low-dose methotrexate usage on primary bone formation in young rats and potential protective effects of folinic acid supplementary treatment.
Topics: Aging; Animals; Bone and Bones; Bone Marrow Cells; Cell Count; Chondrocytes; Dietary Supplements; Dose-Response Relationship, Drug; Growth Plate; Leucovorin; Male; Methotrexate; Organ Size; Osteoblasts; Osteoclasts; Osteogenesis; Protective Agents; Rats; Rats, Sprague-Dawley; Stem Cells | 2009 |
Therapeutic drug monitoring of methotrexate in cerebrospinal fluid after systemic high-dose infusion in children: can the burden of intrathecal methotrexate be reduced?
Topics: Adolescent; Aging; Antimetabolites, Antineoplastic; Biotransformation; Child; Child, Preschool; Drug Monitoring; Humans; Infant; Infusions, Intravenous; Injections, Spinal; Leukemia; Mass Spectrometry; Methotrexate; Neoplasms; Retrospective Studies; Risk Assessment; Young Adult | 2010 |
Increasing age at diagnosis and worsening renal function in patients with primary central nervous system lymphoma.
Topics: Aged; Aging; Central Nervous System Neoplasms; Female; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Kidney Diseases; Longitudinal Studies; Lymphoma; Male; Methotrexate; Middle Aged; Retrospective Studies; Statistics, Nonparametric | 2011 |
CARCINOMA OF THE COLON IN ULCERATIVE COLITIS.
Topics: Aged; Aging; Cell Biology; Colitis; Colitis, Ulcerative; Colonic Neoplasms; Fluorouracil; Humans; Mechlorethamine; Methotrexate; Neoplasms; Pathology; Polyps; Radiography; Surgical Procedures, Operative | 1964 |
ACUTE LEUKEMIA IN ADOLESCENTS AND ADULTS. RESULTS OF TREATMENT OVER THREE CONSECUTIVE 5-YEAR PERIODS.
Topics: Acute Disease; Adolescent; Adult; Aging; Cortisone; Drug Therapy; Humans; Leukemia; Mercaptopurine; Methotrexate; Penicillins; Prednisone; Statistics as Topic; Streptomycin | 1965 |
Adjuvant chemotherapy in elderly patients with breast cancer: a survey of the Breast International Group (BIG).
Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Fluorouracil; Geriatric Assessment; Health Care Surveys; Humans; Medical Oncology; Methotrexate; Patient Care Planning; Practice Patterns, Physicians'; Predictive Value of Tests | 2004 |
Lymphocyte capping in muscular dystrophies.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Female; Fluorescent Antibody Technique; Humans; Immunologic Capping; Infant; Interferons; Leukemia, Myeloid; Lymphocytes; Male; Methotrexate; Middle Aged; Muscular Dystrophies; Osteosarcoma; Subacute Sclerosing Panencephalitis | 1982 |
Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance.
Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Creatinine; Cyclophosphamide; Female; Fluorouracil; Humans; Methotrexate | 1984 |
Methotrexate effects on hepatic betaine levels in choline-supplemented and choline-deficient rats.
Topics: Aging; Animals; Betaine; Choline; Choline Deficiency; Liver; Male; Methionine; Methotrexate; Rats; Rats, Inbred Strains | 1982 |
Adolescent and adult acute lymphoblastic leukemia: prognostic features and outcome of therapy. A study of 293 patients.
Topics: Actuarial Analysis; Adolescent; Adult; Aging; Bacterial Infections; Child; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphoid; Leukocyte Count; Male; Methotrexate; Middle Aged; Prednisone; Prognosis; Receptors, Antigen, B-Cell; Retrospective Studies; Thioinosine; Vincristine | 1982 |
Results of induction therapy with vincristine and prednisone alone in adult acute lymphoblastic leukemia: report of 43 patients and review of the literature.
Topics: Adolescent; Adult; Aged; Aging; Drug Therapy, Combination; Humans; Leukemia, Lymphoid; Methotrexate; Middle Aged; Prednisone; Remission, Spontaneous; Vincristine | 1982 |
Evidence for an inducible repair-recombination system in the female germ line of Drosophila melanogaster. I. Induction by inhibitors of nucleotide synthesis and by gamma rays.
Topics: Aging; Animals; Antimetabolites; Cesium Radioisotopes; DNA Repair; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Fertility; Gamma Rays; Kinetics; Male; Methotrexate; Oocytes; Oviposition; Recombination, Genetic; Retroelements; Time Factors; Uracil | 1995 |
Use of methotrexate in older patients. A risk-benefit assessment.
Topics: Aged; Aging; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Folic Acid; Humans; Methotrexate; Risk Assessment | 1996 |
Total and free methotrexate pharmacokinetics in elderly patients with rheumatoid arthritis. A comparison with young patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid; Creatinine; Female; Humans; Injections, Intramuscular; Male; Methotrexate; Middle Aged | 1997 |
Age-depending effects of methotrexate treatment on systemic bone turnover in experimental adjuvant arthritis.
Topics: Absorptiometry, Photon; Aging; Animals; Arthritis, Experimental; Biomarkers; Body Weight; Bone and Bones; Bone Density; Bone Regeneration; Foot; Immunosuppressive Agents; Male; Methotrexate; Organ Size; Rats; Rats, Sprague-Dawley | 1999 |
[Treatment of acute leukemia].
Topics: Acute Disease; Adolescent; Adult; Aging; Asparaginase; Child; Child, Preschool; Daunorubicin; Humans; Infant; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Methotrexate; Remission, Spontaneous; Time Factors | 1977 |
Age-related pharmacokinetics of high-dose methotrexate in patients with osteosarcoma.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Kinetics; Methotrexate; Middle Aged; Osteosarcoma | 1979 |
Thymosin induced changes in the cell cycle of lymphocytes from aging neonatally thymectomized rats.
Topics: Aging; Animals; Animals, Newborn; Cell Division; Cells, Cultured; Female; Lectins; Lymph Nodes; Lymphocyte Activation; Lymphocytes; Methotrexate; Rats; Thymectomy; Thymosin; Thymus Hormones | 1976 |
Renal function and the rate of disappearance of methotrexate from serum.
Topics: Adult; Aged; Aging; Creatinine; Female; Half-Life; Humans; Injections, Intravenous; Kidney; Kidney Diseases; Kidney Function Tests; Kinetics; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged | 1975 |
Tryptophan and serotonin metabolism in familial erythrophagocytic lymphohistiocytosis.
Topics: Aging; Amino Acids; Biopterins; Child, Preschool; Etoposide; Histiocytosis, Non-Langerhans-Cell; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Male; Methotrexate; Neopterin; Prednisolone; Serotonin; Tryptophan | 1992 |
Aminoterminal propeptide of type III procollagen in cerebrospinal fluid. Variation with age and in childhood leukemia.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Peptide Fragments; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Procollagen; Radioimmunoassay | 1991 |
The effect of age on methotrexate efficacy and toxicity.
Topics: Adult; Aged; Aging; Arthritis, Rheumatoid; Creatinine; Humans; Leukocyte Count; Methotrexate; Middle Aged | 1991 |
7-Hydroxymethotrexate concentrations in serum and cerebrospinal fluid of children with acute lymphoblastic leukemia.
Topics: Aging; Antineoplastic Agents; Child; Child, Preschool; Folic Acid Antagonists; Humans; Infant; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 1990 |
Age-dependent expression of a novel protein in mouse liver immunologically and functionally homologous with dihydrofolate reductase.
Topics: Aging; Animals; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Isoenzymes; Kinetics; Liver; Methotrexate; Mice; Mice, Inbred Strains; Molecular Weight; Tetrahydrofolate Dehydrogenase | 1989 |
Risk factors for interstitial pneumonitis following allogeneic bone marrow transplantation for severe aplastic anemia: a preliminary report.
Topics: Aging; Anemia, Aplastic; Bone Marrow Transplantation; Combined Modality Therapy; Cytomegalovirus Infections; Graft vs Host Disease; Humans; Leukemia; Methotrexate; Prognosis; Pulmonary Fibrosis; Registries; Risk; Whole-Body Irradiation | 1987 |
Age and dose of chemotherapy as major prognostic factors in a trial of adjuvant therapy of osteosarcoma combining two alternating drug combinations and early prophylactic lung irradiation. French Bone Tumor Study Group.
Topics: Adolescent; Adult; Aging; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Doxorubicin; Female; Femoral Neoplasms; Fibula; Humans; Humerus; Lung Neoplasms; Male; Methotrexate; Mitomycin; Mitomycins; Osteosarcoma; Prognosis; Radiotherapy Dosage; Tibia; Time Factors; Vincristine | 1988 |
High-dose methotrexate: pharmacokinetics in children and young adults.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Half-Life; Humans; Infant; Methotrexate | 1988 |
Nonmelanoma skin tumors in long-term photochemotherapy treatment of psoriasis. An 8-year follow-up study.
Topics: Adult; Aged; Aging; Arsenic; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Combined Modality Therapy; Dose-Response Relationship, Radiation; Etretinate; Follow-Up Studies; Humans; Melanoma; Methotrexate; Middle Aged; Psoriasis; PUVA Therapy; Skin Neoplasms | 1986 |
Management of cancer in the elderly. Implications of the aging process.
Topics: Aged; Aging; Colonic Neoplasms; Doxorubicin; Female; Hodgkin Disease; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms; Rectal Neoplasms; Semustine; Socioeconomic Factors; Uterine Cervical Neoplasms | 1985 |
[Addenda to the study of the effect of carcinostatic drugs on human beings. II. Variations in peripheral blood in young and adult albino rats after administration of sublethal doses, equally divided per body weight].
Topics: Aging; Animals; Blood Cell Count; Blood Cells; Body Weight; Hemoglobins; Mechlorethamine; Methotrexate; Mitomycins; Rats | 1968 |