methotrexate has been researched along with Adverse Drug Event in 167 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (11.98) | 18.7374 |
| 1990's | 6 (3.59) | 18.2507 |
| 2000's | 19 (11.38) | 29.6817 |
| 2010's | 76 (45.51) | 24.3611 |
| 2020's | 46 (27.54) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Ding, D; Fang, H; Kelly, R; Liu, Z; Shi, Q; Tong, W | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bhardwaj, TR; Gaba, T; Malhotra, M; Matharoo, S; Rawal, RK; Sharma, R; Singla, N | 1 |
| Bakker, T; Jessurun, NT; Ten Klooster, PM; Van Lint, JA; van Puijenbroek, EP; Vonkeman, HE | 1 |
| Badia, X; Cabero-Martínez, A; de la Fuente, A; Del Cerro, I; Domínguez-Pinilla, N; Gallardo, E; Giró-Perafita, A; González-Barca, E; Gros, L; Roldán, A; Tasso, M; Torrent, M | 1 |
| Arunkumar, G; Kaur, H; Paul, SFD; Ramalingam, R; Scott, JX; Sneha, LM; Srinivasan, A | 1 |
| Baumrin, E; Berna, R; Margolis, DJ; Mitra, N; Rosenbach, M | 1 |
| Altunay, IK; Erdem, Y; Ozkur, E; Tuncel, D; Ugurer, E | 1 |
| Kaczmarska, A; Lejman, M; Śliwa-Tytko, P; Zawitkowska, J | 1 |
| Cheng, XP; Mao, Q; Olatunji, OJ; Pan, S; Wang, QH; Wu, YJ; Yang, K; Zuo, J | 1 |
| Jiang, R; Mei, S; Zhao, Z | 1 |
| Bhardwaj, N; Chauhan, P; Jindal, R; Roy, S | 1 |
| Bahuguna, A; Das, P; Sapra, D; Singh, GK | 1 |
| Ashforth, G; Ouellette, S; Razi, S; Shah, R; Wassef, C | 1 |
| Ding, T; Li, Z; Qiu, X; Sun, K; Tao, H; Wu, Z; Zhong, M | 1 |
| Cushen, BF; Hancock, BW; Hills, A; Kandiah, K; Palmer, JE; Parker, VL; Singh, K; Tidy, JA; Winter, MC | 1 |
| Choi, YM; Kim, JM; Ko, JS; Moon, JS; Yang, HR | 1 |
| Dhir, V; Dung, N; Jain, S; Kaul, KK; Kumar, S; Naidu, GSRSNK; Prasad, CB; Sharma, A; Sharma, SK | 1 |
| Allahyari, A; Arasteh, O; Askari, VR; Ataei Azimi, S; Hosseinjani, H; Jafari, F | 1 |
| Adiao, KJB; Prado, MB | 1 |
| Abhishek, A; Aithal, GP; Card, T; Fox, CP; Grainge, MJ; Mallen, CD; Nakafero, G; Riley, RD; Stevenson, MD; Taal, MW; van der Windt, DA; Williams, HC | 1 |
| Adiay, C; Akin Cakici, O; Apti Sengun, O; Ay, P; Enul, H; Ergun, T; Haklar, G; Hosgoren Tekin, S; Seckin, D; Sili, U; Yilmaz, S | 1 |
| Asaad, GF; El-Dakroury, WA; El-Gizawy, SA; Shabana, ME; Zewail, MB | 1 |
| Bei, W; Feng, H; Kai, C; Liuqing, C; Qian, J; Ruili, J; Zilu, Q | 1 |
| Bouma, G; Bulatović Ćalasan, M; de Boer, NKH; de Jonge, R; Fidder, HH; Koehestanie, P; Kuyvenhoven, JP; Lutgens, MWMD; Mahmmod, N; Mares, WGN; Montazeri, NSM; Nissen, LHC; Oldenburg, B; Rietdijk, ST; Struys, EA; Sundaresan, J; van Asseldonk, DP; van de Meeberg, MM | 1 |
| Abd El-Alim, AEF; El-Naseery, NI; El-Sayed, RG; El-Sheikh, SMA; Galal, AAA | 1 |
| Awad, L; Hashim, R; Jain, M; Labadie, JG; Raheel, S | 1 |
| Capparelli, EV; Kawakatsu, S; Kuo, DJ; Le, S; Lin, M; Nikanjam, M; Saunders, I | 1 |
| Crosby, S; Schuh, MJ | 1 |
| Chen, JS; Chen, M; Cui, PG; Fang, H; Gao, XH; Gu, J; Guo, ZP; Jin, HZ; Lai, W; Li, W; Li, YZ; Liu, LF; Liu, XM; Lyu, CZ; Pang, XW; Shi, YL; Song, ZQ; Sun, Q; Wang, G; Xie, HF; Xu, JH; Yu, C; Zhang, W; Zhao, NQ; Zheng, M | 1 |
| Biedroń, G; Brzosko, I; Brzosko, M; Czuszyńska, Z; Dębska-Ślizień, A; Głuszko, P; Hawrot-Kawecka, A; Jakuszko, K; Jeleniewicz, R; Klinger, M; Kucharz, EJ; Kur-Zalewska, J; Madej, M; Majdan, M; Masiak, A; Musiał, J; Rowaiye, OO; Storoniak, H; Szczeklik, W; Sznajd, J; Tłustochowicz, W; Wawrzycka-Adamczyk, K; Wisłowska, M; Wójcik, K; Włudarczyk, A; Zdrojewski, Z | 1 |
| Bast, A; de Jong, SMG; Drent, M; Ebner, NM; Elfferich, MDP; Jessurun, NT; Lewis, EDO; Proesmans, VLJ | 1 |
| Khurrana, T; Malhotra, AK; Raghavendra, S | 1 |
| Bechman, K; Cope, AP; Dennison, E; Galloway, JB; Norton, S; Oke, A; Yates, M | 1 |
| Longo, CJ; Maity, TS | 1 |
| Dokmanovic, L; Gasic, V; Janic, D; Kotur, N; Krstovski, N; Lazic, J; Milosevic, G; Pavlovic, S; Ristivojevic, B; Stankovic, B; Zukic, B | 1 |
| Chandler, RE; Fujiyoshi, Y; Iwasa, E; Kimura, R; Kubota, Y; Norén, GN; Taavola, H; Wakao, R | 1 |
| Block, CA; Robey, RB | 1 |
| Solomon, DH; Sparks, JA | 1 |
| Aladle, DA; El Marghany, AB; El Menshawy, N; Sarhan, MM | 1 |
| Alves, GGB; de Oliveira Rocha, AM; Len, CA; Piotto, DGP; Said, MA; Silva, LSTE; Terreri, MT | 1 |
| Mitsuboshi, S | 1 |
| Flowers, RH; Ninmer, EK; Noland, MM; Rama, B; Saito, M; Vittitow, SL; Zufall, AG | 1 |
| Batthish, M; Berard, RA; Bruns, A; Cabral, DA; Chédeville, G; Duffy, CM; Gerhold, K; Gerschman, T; Guzman, J; McGuire, K; Proulx-Gauthier, JP; Rumsey, DG; Schmeling, H; Shiff, NJ; Soon, G; Tucker, LB | 1 |
| Billiet, T; D'Hooge, R; Deprez, S; Elens, I; Labarque, V; Lemiere, J; Sleurs, C; Uyttebroeck, A; Van Gool, S | 1 |
| Liu, MQ; Liu, S; Liu, YL; Qin, LP; Zhang, Q; Zhang, QY; Zhu, LL | 1 |
| Adas, MA; Allen, VB; Bechman, K; Clarke, BD; Cope, AP; Galloway, JB; Norton, S; Russell, MD; Rutherford, AI; Yates, M | 1 |
| Glynn, RJ; Jacques, P; MacFadyen, JG; Paynter, NP; Ridker, PM; Selhub, J; Solomon, DH; Xu, C | 1 |
| Atalay, E; Basaran, O; Bilginer, Y; Farisogullari, B; Kasap Cuceoglu, M; Kaya Akca, U; Kilic, L; Ozen, S; Sag, E; Yardimci, GK | 1 |
| Bashari, MH; Idjradinata, P; Kaspers, GJL; Rakhmilla, LE; Raspati, H; Reniarti, L; Sari, NM; Supriyadi, E; Suryawan, N; Susanah, S; Zazuli, Z | 1 |
| Dhir, V; Jain, S; Kaur, J; Khanna Sharma, S; Naidu, GS; Pai, V; Sharma, A; Vijaykumar, D | 1 |
| Aalders, K; Bartlett, JMS; Biganzoli, L; Bogaerts, J; Cameron, D; De Valk, B; Khaled, H; Marreaud, S; Tryfonidis, K; Vermorken, J; Welnicka-Jaskiewicz, M | 1 |
| Luu, B; Rodway, GW | 1 |
| de Lange, DW; de Vries, I; Dijkman, MA; Hunault, CC; Koppen, A | 1 |
| Buckley, NA; Chan, BS; Dawson, AH | 1 |
| Dhooge, C; Labarque, V; Laenen, A; Lambrecht, L; Renard, M; Sinnaeve, F; Sleurs, C; Uyttebroeck, A | 1 |
| Kremer, JM; Weinblatt, ME | 1 |
| Costello, R; Dixon, WG; Humphreys, JH; Verstappen, SM | 1 |
| Cooper, MA; Keppel, MP; Orandi, AB; Utterson, EC; Vogel, TP | 1 |
| Li, XL; Liu, YW; Nie, XL; Wang, SZ; Wang, XL; Yu, XT; Zhao, LB; Zhu, C | 1 |
| Bagchi, C; Banerjee, G; Roy, A; Roy, SS; Santra Dhali, R; Tripathi, SK | 1 |
| Cerminara, Z; Duffy, A; Gilmore, S; Nishioka, J; Trovato, J | 1 |
| Chang, SN; Chung, HM; Jung, CR; Kim, CY; Kim, J; Kim, U; Lee, BH; Lee, JM; Lee, S; Oh, H; Park, JH; Ryu, B | 1 |
| Lee, EB | 1 |
| Eppler, B; Haas, JP; Höfel, L; Hügle, B; Schnöbel-Müller, E; Storf, M | 1 |
| Fardet, L; Mazaud, C | 1 |
| Chen, J; Fan, Y; Hong, R; Ma, F; Ou, K; Sang, D; Wang, J; Xu, B; Yuan, P; Zhai, X; Zhao, C | 1 |
| Matsuoka, Y; Narukawa, M | 1 |
| Kalkan, Y; Mercantepe, F; Mercantepe, T; Sehitoglu, İ; Tumkaya, L; Yıldırmıs, S | 1 |
| Barclay, M; Chapman, PT; Drake, J; Frampton, C; OʼDonnell, JL; Stamp, LK; Zhang, M | 1 |
| Grock, A; Mason, J; Vohra, R; Vohra, SS | 1 |
| Cannon, GW; Curtis, JR; Erhardt, DP; Mikuls, TR; Sauer, BC; Teng, CC | 1 |
| Boels, D; Castellan, D; Kassai, B; Patat, AM; Theophile, H; Torrents, R; Vial, T; Villa, A | 1 |
| Al-Khalili, O; England, BR; Mikuls, TR; O'Dell, JR | 1 |
| Barres, BA; Geraghty, AC; Gibson, EM; Goldstein, AK; Greene, JJ; Liddelow, S; Monje, M; Nagaraja, S; Ni, L; Ocampo, A; Pallegar, PN; Tam, LT; Vogel, H; Woo, PJ; Wood, LS | 1 |
| Hügle, B | 1 |
| de Jonge, R; Kloos, RQH; Pieters, R; van den Bos, C; van der Sluis, IM; van Eijkelenburg, NKA | 1 |
| Al Harthi, A; Albaqami, J; Almalag, H; Alshalhoub, R; Bedaiwi, MK; Dessougi, M; Omair, MA | 1 |
| Bhatia, R; Chandrasekaran, D; Hazarika, N; Joshi, P | 1 |
| Kiely, PD; McWilliams, DF; Walsh, DA; Young, A | 1 |
| Anumol, T; Canet, MJ; Cherrington, NJ; Clarke, JD; Goedken, MJ; Hardwick, RN; Lake, AD; Merrell, MD; Snyder, SA; Street, SM | 1 |
| Altés, A; Baiget, M; Casademont, J; Cerdà-Gabaroi, D; Corominas, H; Díaz-Torné, C; Moya, P; Salazar, J | 1 |
| Cherrington, NJ; Coen, M; Goedken, MJ; Hardwick, RN; Holmes, E; Jin, Z; Kyriakides, M | 1 |
| Azevedo, R; Lima, A; Medeiros, R; Monteiro, J; Seabra, V; Sousa, H | 1 |
| Bernardes, M; Canhão, H; Fonseca, JE; Lima, A; Romão, VC | 1 |
| Agra, Y; Moreno-Gómez, AM; Otero, MJ; Santos-Ramos, B | 1 |
| Cleland, L; Kowalski, SM; McKinnon, R; Mohamed, HJ; Proudman, SM; Sorich, MJ; Wiese, MD | 1 |
| Wissing, MD | 1 |
| Mager, DR | 1 |
| Chen, Y; Shen, Z | 1 |
| Achour, Y; Akrout, R; Bahloul, Z; Ben Hamad, M; Chaabane, S; Fourati, H; Keskes, L; Maalej, A; Marzouk, S; Rebai, A | 1 |
| Bananis, E; Burmester, G; Charles-Schoeman, C; Fleischmann, R; Hendrikx, T; Kwok, K; Nash, P; Soma, K; Zerbini, CA | 1 |
| de Jonge, R; den Boer, E; Hazes, JM; Wassenaar, S; Westerman, EM | 1 |
| Kivity, S; Loebstein, R; Mayan, H; Mouallem, M; Zafrir, Y | 1 |
| Chen, M; Ding, H; Du, Y; Gu, L; Hu, M; Li, W; Li, X; Vanarsa, K | 1 |
| Bienvenu, B; de Boysson, H; Samson, M; Watelet, B | 1 |
| Aicart, M; Alcaín, G; Almela, P; Arguelles-Arias, F; Arias-Rivera, ML; Barreiro-de Acosta, M; Barrio, J; Beltrán, B; Benítez, JM; Bermejo, F; Botella, B; Bujanda, L; Busquets, D; Calvet, X; Casanova, MJ; Castaño-Milla, C; Castro, E; Castro, L; Ceballos, D; Chaparro, M; Cortés, X; Domènech, E; Domínguez, M; Domínguez-Antonaya, M; Dueñas, C; Esteve, M; Fernández-Salazar, L; García-Herola, A; García-López, S; García-Planella, E; García-Sánchez, V; García-Sepulcre, MF; Garrido, E; Gisbert, JP; Gómez-García, M; Gomollón, F; González-Lama, Y; Guardiola, J; Gutiérrez, A; Hernández-Martínez, A; Hervías, D; Hinojosa, J; Huguet, JM; Jauregui-Amezaga, A; Khorrami, S; Leo, E; Llaó, J; Lorente-Poyatos, R; Mañosa, M; Marín-Jiménez, I; Marrero, JM; Martín-Arranz, M; Martinez-Montiel, MP; Menacho, M; Merino, O; Monfort, D; Moraleja, I; Muñoz, C; Muñoz, F; Nantes, O; Navarro-Llavat, M; Novella, MT; Opio, V; Pajares, R; Pérez-Calle, JL; Pérez-Martínez, I; Pineda, JR; Ponferrada, A; Ramírez-de la Piscina, P; Ramos, L; Robles-Alonso, V; Rodríguez, C; Rodríguez, GE; Rodríguez-Pérez, A; Rojas-Feria, M; Roncedo, O; Sánchez-Torres, A; Sicilia, B; Taxonera, C; Tosca, J; Van Domselaar, M; Vázquez, JM; Vega-López, AB | 1 |
| Ahmad, S; Bhatnagar, A; Dhawan, V; Dhir, V; Kaur, J; Naidu, S; Sandhu, A; Sharma, A; Sharma, S; Sood, A; Varma, N | 1 |
| Fietz, T; Franke, A; Freund, M; Hänel, M; Knauf, WU; Thiel, E | 1 |
| Aksoylar, S; Cetingul, N; Cinar, M; Eroglu, Z; Gumus, S; Kantar, M; Kosova, B; Tetik, A; Topcuoglu, N; Toroslu, E; Zafer, N | 1 |
| Avanesian, A; Jafari, M; Semnani, S | 1 |
| Bischoff, A | 1 |
| Einarson, A; Jin, C; Koren, G; Lee, CY; Mata, AM; Tanaka, T | 1 |
| Dolzan, V; Faganel Kotnik, B; Grabnar, I; Jazbec, J | 1 |
| de Souza, CB; Ferriani, VP; Pileggi, GS | 1 |
| Inoue, E; Kaneko, H; Kitahama, M; Koseki, Y; Momohara, S; Okamoto, H; Taniguchi, A; Yamanaka, H | 1 |
| Chen, H; Chen, YH; Han, W; Huang, XJ; Liu, DH; Liu, KY; Wang, J; Wang, Y; Xu, LP | 1 |
| Alousi, A; Anderlini, P; Andersson, BS; Berry, D; Bosque, D; Cano, P; Champlin, RE; Couriel, D; de Lima, MJ; Fernandez-Vina, M; Giralt, S; Hosing, C; Jones, RB; Munsell, MF; Parmar, S; Popat, U; Shpall, EJ; Silva, Lde P; Wathen, JK; Westmoreland, M | 1 |
| Bambery, P; Jose, V; Mittal, N; Mittal, R; Sharma, A; Wanchu, A | 1 |
| André, N; Diawara, M; Fousseyni, T; Pasquier, E | 1 |
| Armbrust, W; Bulatović, M; Egberts, TC; Heijstek, MW; Hoppenreijs, EP; Kamphuis, S; Kuis, W; Rademaker, CM; Sinnema, G; van Dijkhuizen, EH; Verkaaik, M; Wulffraat, NM | 1 |
| Tan, KW; Tay, YK | 1 |
| Cui, L; Gao, C; Li, WJ; Li, ZG; Liu, SG; Zhao, XX | 1 |
| Baldi, I; Balzarotti, M; Bottelli, C; Cavalli, F; Chiappella, A; Conconi, A; Ferreri, AJ; Gomez, H; Gospodarowicz, MK; Lopez-Guillermo, A; Martelli, M; Martinelli, G; Merli, F; Novero, D; Orsucci, L; Pavone, V; Ricardi, U; Sarris, AH; Storti, S; Vitolo, U; Zucca, E | 1 |
| Graber, JJ; Omuro, A | 1 |
| Wassenberg, S | 1 |
| Harigai, M; Inokuma, S; Ishiguro, N; Koike, T; Takei, S; Takeuchi, T; Tanaka, Y; Yamanaka, H | 1 |
| Ahmed, M; Gilani, ST; Khan, DA; Khan, FA | 1 |
| Jafari, M; Kislukhin, G; Long, AD; Murphy, ML | 1 |
| Burstein, HJ; Chen, WY; Downing, SR; Gelman, R; Hannagan, K; Isakoff, SJ; Klement, G; Mayer, EL; Winer, EP | 1 |
| Bouma, G; de Boer, NK; Mulder, CJ; Oldenburg, B; Ponsioen, CY; Seinen, ML; van Bodegraven, AA | 1 |
| McLeod, HL; Siva, C; Yokoyama, WM | 1 |
| Bertino, JR; Chabner, BA; Johns, DG | 1 |
| Kaneda, M; Kobayashi, R; Kudoh, K; Miyasaka, K; Oka, M; Sawamura, Y; Suzuki, Y; Terae, S; Tha, KK; Yoshida, M | 1 |
| Kanazawa, M; Kawabata, Y; Kurashima, K; Maeno, Y; Matsushima, H; Sato, N; Sugita, Y; Takayanagi, N; Tokunaga, D; Ubukata, M; Yanagisawa, T | 1 |
| Baudaun, N; Bonniaud, P; Camus, C; Camus, P; Fanton, A; Foucher, P | 1 |
| Abu Eid, M; Audibert, C; Bernardo, R; Bogorin, A; Botelho, C; Dietemann, JL; Jacques, C; Kremer, S; Nogueira, T; Vargas, MI; Zöllner, G | 1 |
| Chalmers, LM; Chamberlain, PA; Chowdhary, S | 1 |
| Cheng, C; Cook, EH; Das, S; Evans, WE; French, D; Frudakis, T; Hijiya, N; Kishi, S; Pei, D; Pui, CH; Relling, MV; Rizzari, C; Rosner, GL | 1 |
| Chédeville, G; Duffy, CM; Scuccimarri, R | 1 |
| Chiusolo, P; Farina, G; Fianchi, L; Fiorini, A; La Torre, G; Laurenti, L; Leone, G; Mannocci, A; Palladino, M; Reddiconto, G; Sica, S; Sorà, F | 1 |
| Alarcón, GS; Gaffo, AL; Gauhar, UA | 1 |
| Chladek, J; Grim, J; Hroch, M; Martinkova, J; Simkova, M; Vaneckova, J | 1 |
| Hanefeld, F; Riehm, H | 1 |
| Fraunfelder, FT | 1 |
| Potts, M | 1 |
| Jørgensen, G | 1 |
| Andersen, WK; Feingold, DS | 1 |
| Nathanson, BN | 1 |
| Schaffner, F | 1 |
| Price, RA | 1 |
| Hahn, P; Hallberg, O; Vikterlöf, KJ | 1 |
| Kas'ianenko, IV | 1 |
| Zimmerman, HJ | 1 |
| Aymard, B; Chabot, F; Cornette, A; Delorme, N; Gerard, H; Kheir, A; Lesur, O; Moreau, L; Polu, JM | 1 |
| Ward, MJ; White, JP | 1 |
| Przybilla, B; Schill, WB | 1 |
| Adler, M; Cremer, M; Henry, JP; Lecocq, E; Quiriny, M; Ros, P | 1 |
| Hennigar, GR | 1 |
| Au, WY; Raisz, LG | 1 |
| Bouletreau, P; Ducluzeau, R | 1 |
| Berry, DH | 1 |
| Simone, J | 1 |
| Fossati, C | 1 |
| Lokich, JJ; Skarin, AT | 1 |
| Kirchmayer, S | 1 |
| Brettner, A; Heitzman, ER; Woodin, WG | 1 |
35 review(s) available for methotrexate and Adverse Drug Event
| Article | Year |
|---|---|
Methotrexate Cutaneous Ulceration: A Systematic Review of Cases.
Topics: Drug Eruptions; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Kidney Diseases; Male; Methotrexate; Middle Aged; Pancytopenia; Skin Neoplasms; Skin Ulcer | 2022 |
Neurotoxicity Associated with Treatment of Acute Lymphoblastic Leukemia Chemotherapy and Immunotherapy.
Topics: Asparaginase; Child; Drug-Related Side Effects and Adverse Reactions; Humans; Immunologic Factors; Immunotherapy, Adoptive; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Leucovorin (folinic acid) rescue for high-dose methotrexate: A review.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Leucovorin; Methotrexate; Neoplasms; Renal Dialysis | 2022 |
Fatal low-dose methotrexate toxicity: A case report and literature review.
Topics: Aged; Arthritis, Psoriatic; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Male; Methotrexate; Psoriasis; Risk Factors | 2022 |
A critical review of methotrexate clinical interactions: role of transporters.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Ketoprofen; Membrane Transport Proteins; Methotrexate | 2023 |
Methotrexate in generalized myasthenia gravis: a systematic review.
Topics: Azathioprine; Drug-Related Side Effects and Adverse Reactions; Humans; Immunosuppressive Agents; Methotrexate; Myasthenia Gravis; Observational Studies as Topic; Prednisone; Randomized Controlled Trials as Topic | 2023 |
Comparing four immunosuppressive agents for chronic spontaneous urticaria-A network meta-analysis.
Topics: Anti-Allergic Agents; Azathioprine; Chronic Disease; Chronic Urticaria; Cyclosporine; Drug-Related Side Effects and Adverse Reactions; Glycosides; Histamine Antagonists; Histamine H1 Antagonists; Humans; Immunosuppressive Agents; Methotrexate; Network Meta-Analysis; Omalizumab; Randomized Controlled Trials as Topic; Treatment Outcome; Urticaria | 2023 |
A 2018 Approach to Combating Methotrexate Toxicity Folic Acid and Beyond.
Topics: Antirheumatic Agents; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Methotrexate; Rheumatic Fever; Vitamin B Complex | 2018 |
A systematic review and network meta-analysis of the safety of early interventional treatments in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Network Meta-Analysis; Randomized Controlled Trials as Topic; Secondary Prevention; Steroids; Treatment Outcome | 2021 |
Does low-dose methotrexate deserve more respect from clinicians?
Topics: Antirheumatic Agents; Dose-Response Relationship, Drug; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Rheumatic Diseases | 2017 |
Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis.
Topics: Child; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Pediatrics; Polymorphism, Single Nucleotide; Risk Factors | 2018 |
[MTX intolerance in children and adolescents with juvenile idiopathic arthritis].
Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Child; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Quality of Life; Treatment Outcome | 2019 |
Genetic polymorphisms in low-dose methotrexate transporters: current relevance as methotrexate therapeutic outcome biomarkers.
Topics: ATP-Binding Cassette Transporters; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Humans; Membrane Transport Proteins; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide | 2014 |
Three decades of low-dose methotrexate in rheumatoid arthritis: can we predict toxicity?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Carrier Proteins; Dietary Supplements; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Methotrexate; Pharmacogenetics; Prognosis; Signal Transduction | 2014 |
The role and utility of measuring red blood cell methotrexate polyglutamate concentrations in inflammatory arthropathies--a systematic review.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis; Child; Clinical Trials as Topic; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Erythrocytes; Female; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Prospective Studies | 2015 |
Chemotherapy- and irradiation-induced bone loss in adults with solid tumors.
Topics: Adult; Antineoplastic Agents; Bone Resorption; Denosumab; Diphosphonates; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Imatinib Mesylate; Methotrexate; Neoplasms; Radioisotopes; Radiotherapy; Taxoids | 2015 |
Methotrexate.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Home Health Nursing; Humans; Long-Term Care; Methotrexate; Neoplasms; Patient Education as Topic; Rheumatic Diseases; Risk Assessment | 2015 |
Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL.
Topics: Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Liver-Specific Organic Anion Transporter 1; Metabolic Networks and Pathways; Methotrexate; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2015 |
The association between reduced folate carrier-1 gene 80G/A polymorphism and methotrexate efficacy or methotrexate related-toxicity in rheumatoid arthritis: A meta-analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Ethnicity; Gene Frequency; Genetic Association Studies; Genotype; Humans; Methotrexate; Polymorphism, Genetic; Reduced Folate Carrier Protein; Treatment Outcome | 2016 |
Treatment of giant-cell arteritis, a literature review.
Topics: Antirheumatic Agents; Azathioprine; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Giant Cell Arteritis; Glucocorticoids; Humans; Medication Therapy Management; Methotrexate; Tumor Necrosis Factor-alpha | 2017 |
Can Drosophila melanogaster represent a model system for the detection of reproductive adverse drug reactions?
Topics: Animals; Cost-Benefit Analysis; Drosophila melanogaster; Drug Design; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Models, Animal; Reproduction; Species Specificity | 2009 |
Pharmacotherapy for primary CNS lymphoma: progress beyond methotrexate?
Topics: Central Nervous System Neoplasms; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Stem Cell Transplantation | 2011 |
[For parenteral gold therapy in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Substitution; Drug-Related Side Effects and Adverse Reactions; Evidence-Based Medicine; Gold Compounds; Humans; Infusions, Intravenous; Methotrexate; Remission Induction; Treatment Outcome | 2011 |
Pharmacogenetics in rheumatology: the prospects and limitations of an emerging field.
Topics: Analgesics, Opioid; Antirheumatic Agents; Azathioprine; Drug Design; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; Forecasting; Genetics, Population; Humans; Male; Methotrexate; Pharmacogenetics; Rheumatic Diseases; Rheumatology; Risk Assessment; United States | 2002 |
Drug-induced and iatrogenic infiltrative lung disease.
Topics: Amiodarone; Anti-Arrhythmia Agents; Drug-Related Side Effects and Adverse Reactions; Humans; Iatrogenic Disease; Lung Diseases; Methotrexate; Pneumonia; Pulmonary Alveoli; Pulmonary Edema; Sarcoidosis, Pulmonary | 2004 |
[Imaging in acute toxic encephalopathy].
Topics: Acute Disease; Alcohol Deterrents; Anticonvulsants; Carbon Monoxide Poisoning; Diagnosis, Differential; Disulfiram; Drug-Related Side Effects and Adverse Reactions; Emergency Treatment; Ethanol; Hazardous Substances; Heavy Metal Poisoning; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methanol; Methotrexate; Myelinolysis, Central Pontine; Neuroradiography; Neurotoxicity Syndromes; Substance-Related Disorders; Wernicke Encephalopathy | 2004 |
Pulmonary manifestations of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lung Diseases; Male; Methotrexate; Pleural Diseases; Sex Factors; Smoking | 2007 |
Adverse drug interactions clinically important for the dermatologist.
Topics: Anti-Bacterial Agents; Antifungal Agents; Cyclosporine; Dermatology; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Histamine Antagonists; Humans; Methotrexate; Retinoids; Risk Factors | 1995 |
Hepatic drug metabolism and adverse hepatic drug reactions.
Topics: Adaptation, Biological; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholestasis; Chronic Disease; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Endoplasmic Reticulum; Enzyme Induction; Free Radicals; Glucose-6-Phosphatase; Halothane; Humans; Liver; Methotrexate; Microsomes, Liver; Oxyphenisatin Acetate; Rats; Vinyl Chloride | 1975 |
Histopathology of CNS leukemia and complications of therapy.
Topics: Blood-Brain Barrier; Brain; Calcinosis; Child; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug-Related Side Effects and Adverse Reactions; Humans; Leukemia; Leukoencephalopathy, Progressive Multifocal; Meningeal Neoplasms; Methotrexate; Radiotherapy; Vascular Diseases | 1979 |
Drug-induced adverse pulmonary reactions.
Topics: Amiodarone; Asthma; Bleomycin; Carmustine; Drug-Related Side Effects and Adverse Reactions; Gold; Humans; Hydrochlorothiazide; Hypertension, Pulmonary; Lung Diseases; Lupus Erythematosus, Systemic; Lymphatic Diseases; Mediastinum; Methotrexate; Nitrofurantoin; Penicillamine; Pleural Effusion; Pulmonary Edema; Pulmonary Eosinophilia; Pulmonary Fibrosis; Ritodrine | 1985 |
[Side effects of drugs on male fertility].
Topics: Anabolic Agents; Animals; Antifungal Agents; Antineoplastic Agents; Azathioprine; Colchicine; Dacarbazine; Depression, Chemical; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Fertility; Glucocorticoids; Gonadal Steroid Hormones; Histamine H1 Antagonists; Humans; Male; Methotrexate; Retinoids; Sperm Motility; Sperm Transport; Spermatogenesis | 1985 |
[Drug-induced hepatic lesions].
Topics: Adenoma; Amiodarone; Amphetamines; Antineoplastic Agents; Budd-Chiari Syndrome; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Contraceptive Agents; Drug-Related Side Effects and Adverse Reactions; Female; Hemangiosarcoma; Humans; Liver Cirrhosis; Liver Neoplasms; Methotrexate | 1986 |
Drugs toxic to bone.
Topics: Adrenal Cortex Hormones; Antacids; Antibiotics, Antineoplastic; Anticoagulants; Anticonvulsants; Bone and Bones; Bone Diseases; Cadmium; Cathartics; Chronic Disease; Dactinomycin; Diuretics; Drug-Related Side Effects and Adverse Reactions; Fluorides; Humans; Hyperparathyroidism, Secondary; Iron; Lead; Methotrexate; Plicamycin; Radium; Tetracycline; Vitamin A; Vitamin D | 1972 |
[Liver damage due to drugs. I].
Topics: Arsenicals; Chemical and Drug Induced Liver Injury; Chloramphenicol; Cholestasis; Coumarins; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Halothane; Humans; Imipramine; Liver; Methotrexate; Methyldopa; Nicotinic Acids; Oxacillin; Phenylbutazone; Testosterone; Tetracycline | 1974 |
14 trial(s) available for methotrexate and Adverse Drug Event
| Article | Year |
|---|---|
Etanercept biosimilar (recombinant human tumor necrosis factor-α receptor II: IgG Fc fusion protein) and methotrexate combination therapy in Chinese patients with moderate-to-severe plaque psoriasis: a multicentre, randomized, double-blind, placebo-contro
Topics: Adult; Biosimilar Pharmaceuticals; China; Double-Blind Method; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Etanercept; Female; Humans; Immunoglobulin Fc Fragments; Immunoglobulin G; Male; Methotrexate; Middle Aged; Placebos; Psoriasis; Receptors, Tumor Necrosis Factor, Type II; Recombinant Fusion Proteins; Severity of Illness Index; Treatment Outcome | 2020 |
Adverse effects related to methotrexate polyglutamate levels: adjudicated results from the cardiovascular inflammation reduction trial.
Topics: Aged; Antirheumatic Agents; Cardiovascular Diseases; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Polyglutamic Acid | 2021 |
Cardiac safety, efficacy, and correlation of serial serum HER2-extracellular domain shed antigen measurement with the outcome of the combined trastuzumab plus CMF in women with HER2-positive metastatic breast cancer: results from the EORTC 10995 phase II
Topics: Anthracyclines; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cardiotoxicity; Cyclophosphamide; Disease-Free Survival; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Heart; Humans; Methotrexate; Neoplasm Metastasis; Receptor, ErbB-2; Trastuzumab | 2017 |
A Pilot Randomized Controlled Double-Blind Trial of High- Versus Low-Dose Weekly Folic Acid in People With Rheumatoid Arthritis Receiving Methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Patient Acuity; Pilot Projects; Treatment Outcome; Vitamin B Complex | 2019 |
Efficacy and safety of tofacitinib following inadequate response to conventional synthetic or biological disease-modifying antirheumatic drugs.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Piperidines; Pyrimidines; Pyrroles; Treatment Outcome | 2016 |
Treatment of primary mediastinal large B cell lymphoma with an alternating chemotherapy regimen based on high-dose methotrexate.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Diagnosis, Differential; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Mediastinal Neoplasms; Methotrexate; Middle Aged; Recurrence; Survival Rate; Treatment Outcome; Young Adult | 2009 |
Safety and immunogenicity of varicella vaccine in patients with juvenile rheumatic diseases receiving methotrexate and corticosteroids.
Topics: Adolescent; Adrenal Cortex Hormones; Arthritis, Juvenile; Chickenpox Vaccine; Child; Child, Preschool; Dermatomyositis; Disease Progression; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Injections, Subcutaneous; Male; Methotrexate; Scleroderma, Systemic; Vaccines, Attenuated; Young Adult | 2010 |
Low-dose MTX combined with low-dose methylprednisolone as a first-line therapy for the treatment of acute GVHD: safety and feasibility.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Administration Schedule; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Graft vs Host Disease; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Survival Rate; Treatment Outcome | 2011 |
Prophylaxis of graft-versus-host disease in unrelated donor transplantation with pentostatin, tacrolimus, and mini-methotrexate: a phase I/II controlled, adaptively randomized study.
Topics: Adenosine Deaminase Inhibitors; Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Intention to Treat Analysis; Male; Methotrexate; Middle Aged; Pentostatin; Survival Analysis; Tacrolimus; Transplantation Conditioning | 2011 |
Children treated with metronomic chemotherapy in a low-income country: METRO-MALI-01.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Child; Child, Preschool; Cyclophosphamide; Developing Countries; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Male; Maximum Tolerated Dose; Methotrexate; Pilot Projects; Prospective Studies; Retinoblastoma; Treatment Outcome; Vincristine; Wilms Tumor | 2011 |
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Doxorubicin; Drug-Related Side Effects and Adverse Reactions; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Prednisone; Prospective Studies; Recurrence; Rituximab; Survival Analysis; Testicular Neoplasms; Treatment Outcome; Vincristine | 2011 |
Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics.
Topics: Administration, Metronomic; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Pharmacological; Blood Platelets; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Drug-Related Side Effects and Adverse Reactions; Female; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Middle Aged; Neoplasm Staging; Neovascularization, Pathologic; Piperidines; Platelet Factor 4; Proteomics; Quinazolines; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2012 |
A pilot study of pharmacokinetically guided dosing of oral methotrexate in the initial phase of psoriasis treatment.
Topics: Administration, Oral; Adult; Aged; Dermatologic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Erythrocytes; Female; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Psoriasis; Severity of Illness Index; Treatment Outcome | 2008 |
Acute lymphocytic leukemia in childhood.
Topics: Asparaginase; Black People; Bone Marrow Examination; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunosuppression Therapy; Infections; Injections, Spinal; Leukemia, Lymphoid; Leukopenia; Male; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1974 |
118 other study(ies) available for methotrexate and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Models, Biological; Predictive Value of Tests | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Design, synthesis and ex vivo evaluation of colon-specific azo based prodrugs of anticancer agents.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Cell Line, Tumor; Colon; Colonic Neoplasms; Drug Design; Drug-Related Side Effects and Adverse Reactions; Feces; Humans; Inhibitory Concentration 50; Mesalamine; Prodrugs; Rats | 2013 |
Neuropsychiatric adverse drug reactions associated with low dose methotrexate in rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Quality of Life | 2022 |
Incidence and management of patients with methotrexate delayed elimination in the clinical practice: A Delphi study.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Child; Delphi Technique; Drug-Related Side Effects and Adverse Reactions; Humans; Incidence; Methotrexate; Neoplasms | 2023 |
Evaluation of cytogenetic and molecular markers with MTX-mediated toxicity in pediatric acute lymphoblastic leukemia patients.
Topics: Adolescent; Child; Child, Preschool; Cytogenetic Analysis; Drug-Related Side Effects and Adverse Reactions; Genotype; Humans; Infant; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Undesirable repigmentation in vitiligo patient receiving methotrexate therapy for the treatment of psoriasis: treatment or side effect?
Topics: Adult; Drug-Related Side Effects and Adverse Reactions; Humans; Male; Melanocytes; Methotrexate; Psoriasis; Vitiligo | 2022 |
Glycolysis aggravates methotrexate toxicity by fueling RFC1-controlled intestinal absorption in rheumatic rats.
Topics: Adenosine Triphosphate; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Glycolysis; Humans; Intestinal Absorption; Methotrexate; Rats | 2022 |
Methotrexate Toxicity: A Case Series from a Tertiary Care Center in Northern India.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; India; Leucovorin; Methotrexate; Risk Factors; Tertiary Care Centers | 2022 |
Methotrexate toxicity in psoriasis-A multicentric retrospective study.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; India; Leucovorin; Methotrexate; Psoriasis; Retrospective Studies | 2022 |
Risk factors for high-dose methotrexate associated toxicities in patients with primary central nervous system lymphoma.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Central Nervous System; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Lymphoma; Methotrexate; Risk Factors; Vindesine | 2022 |
Flat-dose versus weight or body surface area-based methotrexate dosing in low-risk gestational trophoblastic neoplasia.
Topics: Body Surface Area; Dactinomycin; Drug-Related Side Effects and Adverse Reactions; Female; Gestational Trophoblastic Disease; Humans; Leucovorin; Methotrexate; Neoplasm Recurrence, Local; Pregnancy; Retrospective Studies | 2023 |
The Effectiveness and Safety of Methotrexate as the First-Line Immunomodulator of Maintenance Therapy in Pediatric Crohn Disease.
Topics: Adult; Child; Crohn Disease; Drug-Related Side Effects and Adverse Reactions; Humans; Immunologic Factors; Immunosuppressive Agents; Infant, Newborn; Methotrexate; Remission Induction; Retrospective Studies; Treatment Outcome | 2023 |
Long-term persistence of oral methotrexate and associated factors in rheumatoid arthritis: a retrospective cohort study.
Topics: Anti-Citrullinated Protein Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Retrospective Studies; Treatment Outcome | 2023 |
Risk stratified monitoring for methotrexate toxicity in immune mediated inflammatory diseases: prognostic model development and validation using primary care data from the UK.
Topics: Adult; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Primary Health Care; Prognosis; Retrospective Studies; United Kingdom | 2023 |
Immunogenicity, efficacy, and safety of CoronaVac and Pfizer/BioNTech mRNA vaccines in patients with psoriasis receiving systemic therapies: A prospective cohort study.
Topics: Antibodies, Neutralizing; Antibodies, Viral; Biological Factors; COVID-19; COVID-19 Vaccines; Drug-Related Side Effects and Adverse Reactions; Humans; Immunogenicity, Vaccine; Infliximab; Methotrexate; Prospective Studies; Psoriasis; SARS-CoV-2; Vaccines, Inactivated | 2023 |
Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chitosan; Clove Oil; Drug-Related Side Effects and Adverse Reactions; Leflunomide; Methotrexate; Rats; Surface-Active Agents; Tumor Necrosis Factor-alpha | 2023 |
Therapeutic drug monitoring of methotrexate in patients with Crohn's disease.
Topics: Adult; Aged; Antirheumatic Agents; Chemical and Drug Induced Liver Injury; Crohn Disease; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2023 |
Safety update: methotrexate and photosensitivity reactions.
Topics: Drug-Related Side Effects and Adverse Reactions; Government Agencies; Humans; Methotrexate | 2023 |
Anti-arthritic effect of β-caryophyllene and its ameliorative role on methotrexate and/or leflunomide-induced side effects in arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Arthritis, Experimental; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Immunosuppressive Agents; Leflunomide; Male; Methotrexate; Polycyclic Sesquiterpenes; Rats; Rats, Wistar; Sesquiterpenes | 2019 |
Population pharmacokinetic analysis of high-dose methotrexate in pediatric and adult oncology patients.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Glomerular Filtration Rate; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Models, Biological; Neoplasms; Young Adult | 2019 |
Methotrexate Central Nervous System Toxicity Identified in a Pharmacogenomics Pharmacist Consult Patient.
Topics: Aged; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Methotrexate; Nervous System; Pharmacists; Pharmacogenetics; Referral and Consultation; Russia | 2019 |
Treatment and its side effects in ANCA-associated vasculitides - Study based on POLVAS registry data.
Topics: Adult; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Poland; Prognosis; Registries; Retrospective Studies; Rituximab; Survival Rate | 2020 |
Ranking Self-reported Gastrointestinal Side Effects of Pharmacotherapy in Sarcoidosis.
Topics: Adult; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Gastrointestinal Diseases; Humans; Immunosuppressive Agents; Male; Methotrexate; Mycophenolic Acid; Needs Assessment; Prednisone; Quality of Life; Sarcoidosis; Self Report; Weight Gain | 2020 |
Yet another case of acute methotrexate toxicity due to accidental overdose.
Topics: Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Substance-Related Disorders | 2020 |
Is background methotrexate advantageous in extending TNF inhibitor drug survival in elderly patients with rheumatoid arthritis? An analysis of the British Society for Rheumatology Biologics Register.
Topics: Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunosenescence; Male; Medication Adherence; Methotrexate; Registries; Treatment Outcome; Tumor Necrosis Factor Inhibitors; United Kingdom | 2020 |
Adverse Drug Reactions in Canada (2009-2018): Insights from the Canada Vigilance Database.
Topics: Adverse Drug Reaction Reporting Systems; Canada; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; Hospitalization; Humans; Male; Methotrexate; Patient Safety | 2020 |
Pharmacogenomic Markers of Methotrexate Response in the Consolidation Phase of Pediatric Acute Lymphoblastic Leukemia Treatment.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Gene Expression Regulation, Neoplastic; Genotype; Humans; Infant; Male; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Interstitial Lung Disease as an Adverse Drug Reaction in Japan: Exploration of Regulatory Actions as a Basis for High Reporting.
Topics: Adverse Drug Reaction Reporting Systems; Antimetabolites, Antineoplastic; Drug and Narcotic Control; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Japan; Lung Diseases, Interstitial; Methotrexate; Product Surveillance, Postmarketing; Protein Kinase Inhibitors; Retrospective Studies | 2020 |
Adverse Effects of Low-Dose Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate | 2020 |
Adverse Effects of Low-Dose Methotrexate.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate | 2020 |
Cyclin D1 G870A Polymorphism: Relation to the Risk of ALL Development, Prognosis Impact, and Methotrexate Cytotoxicity.
Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Cyclin D1; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Infant; Liver Function Tests; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Rate | 2020 |
Adverse drug reactions associated with treatment in patients with chronic rheumatic diseases in childhood: a retrospective real life review of a single center cohort.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Child; Cohort Studies; Dermatomyositis; Drug-Related Side Effects and Adverse Reactions; Glucocorticoids; Humans; Lupus Erythematosus, Systemic; Methotrexate; Retrospective Studies; Rheumatic Diseases; Risk Factors | 2020 |
Risk of haematological events and preventive effect of folic acid in methotrexate users with chronic kidney disease and rheumatoid arthritis: Analysis of the Japanese Adverse Drug Event Report database.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Japan; Methotrexate; Renal Insufficiency, Chronic | 2021 |
Methotrexate Monitoring in Dermatology- A Retrospective Cohort Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Chemical Analysis; Child; Child, Preschool; Dermatology; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Liver Function Tests; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Retrospective Studies; Skin Diseases; Time Factors; Young Adult | 2021 |
Parent-Reported Medication Side Effects and Their Impact on Health-Related Quality of Life in Children With Juvenile Idiopathic Arthritis.
Topics: Arthritis, Juvenile; Canada; Child; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Parents; Prednisone; Quality of Life | 2022 |
Methylene tetrahydrofolate reductase A1298C polymorphisms influence the adult sequelae of chemotherapy in childhood-leukemia survivors.
Topics: Adolescent; Adult; Brain; Cancer Survivors; Child; Child, Preschool; Cognition; Diffusion Magnetic Resonance Imaging; Disease Progression; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid Antagonists; Genotype; Humans; Intelligence Tests; Magnetic Resonance Imaging; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rest; Retrospective Studies; tau Proteins; Young Adult | 2021 |
[Research progress on protective effect of traditional Chinese medicine and natural medicine on methotrexate-induced liver toxicity].
Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Medicine, Chinese Traditional; Methotrexate; Oxidative Stress | 2021 |
Real-world data on MTX tolerance with regimens used in children versus adults.
Topics: Adult; Antirheumatic Agents; Child; Clinical Protocols; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Surveys and Questionnaires; Treatment Outcome | 2021 |
Monitoring Of High-Dose Methotrexate (Mtx)-Related Toxicity and Mtx Levels in Children with Acute Lymphoblastic Leukemia: A Pilot-Study in Indonesia.
Topics: Antimetabolites, Antineoplastic; Child; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Indonesia; Infusions, Intravenous; Male; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 2021 |
Assessing methotrexate intolerance and its prevalence in rheumatoid arthritis: Development and validation of the MISA questionnaire.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; India; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prevalence; Reproducibility of Results; Risk Assessment; Risk Factors; Surveys and Questionnaires | 2021 |
Is it really safe to withhold folinic acid when less than 1000 mg/m
Topics: Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Humans; Leucovorin; Methotrexate | 2017 |
Response to the letter regarding "Is it really safe to withhold folinic acid when less than 1000 mg/m
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Leucovorin; Methotrexate | 2017 |
The role of the MTHFR C677T polymorphism in methotrexate-induced toxicity in pediatric osteosarcoma patients.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Homozygote; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Osteosarcoma; Pharmacogenetics; Polymorphism, Genetic; Retrospective Studies | 2017 |
Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis taking methotrexate.
Topics: Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate | 2018 |
Response to: Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis by Kremer and Weinblatt.
Topics: Alcohol Drinking; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Gastrointestinal Diseases; Humans; Methotrexate | 2018 |
Azathioprine-Associated Complete NK Cell Deficiency.
Topics: Azathioprine; CD56 Antigen; Child, Preschool; Cytotoxicity, Immunologic; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunologic Deficiency Syndromes; Immunophenotyping; Immunosuppressive Agents; Inflammatory Bowel Diseases; K562 Cells; Killer Cells, Natural; Methotrexate; Remission Induction; Tumor Necrosis Factor-alpha; Withholding Treatment | 2017 |
A Case of Inappropriate Self-Medication Compounded with Prescribing
Topics: Dermatologic Agents; Drug-Related Side Effects and Adverse Reactions; Humans; Male; Medication Errors; Methotrexate; Middle Aged; Psoriasis; Self Medication | 2018 |
A single center retrospective analysis of a protocol for high-dose methotrexate and leucovorin rescue administration.
Topics: Adult; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid Antagonists; Guideline Adherence; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Outcome Assessment, Health Care; Retrospective Studies; United States | 2019 |
Development of an alternative zebrafish model for drug-induced intestinal toxicity.
Topics: Animal Testing Alternatives; Animals; Caco-2 Cells; Diclofenac; Drug-Related Side Effects and Adverse Reactions; Humans; Indomethacin; Intestinal Mucosa; Lethal Dose 50; Methotrexate; Rats, Sprague-Dawley; Toxicity Tests; Zebrafish | 2018 |
A review of sarilumab for the treatment of rheumatoid arthritis.
Topics: Adalimumab; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Resistance; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Neutropenia; Receptors, Interleukin-6 | 2018 |
Successful treatment of methotrexate intolerance in juvenile idiopathic arthritis using eye movement desensitization and reprocessing - treatment protocol and preliminary results.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Child; Clinical Protocols; Desensitization, Psychologic; Drug-Related Side Effects and Adverse Reactions; Eye Movements; Female; Humans; Male; Methotrexate; Prospective Studies; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2018 |
Folate Supplementation During Methotrexate Therapy: A Population-based Retrospective Cohort Study.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Child; Child, Preschool; Databases, Factual; Dermatologic Agents; Dietary Supplements; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid; Guideline Adherence; Humans; Infant; Infant, Newborn; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Practice Patterns, Physicians'; Retrospective Studies; Risk Factors; Treatment Outcome; Vitamin B Complex; Young Adult | 2018 |
Analysis of the activity and safety of weekly low-dose bevacizumab-based regimens in heavily pretreated patients with metastatic breast cancer.
Topics: Adult; Aged; Albumins; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Etoposide; Female; Humans; Irinotecan; Methotrexate; Middle Aged; Neoplasm Metastasis; Paclitaxel; Pemetrexed; Progression-Free Survival; Treatment Outcome | 2018 |
Comparison of Serious Adverse Event Profiles Among Antirheumatic Agents Using Japanese Adverse Drug Event Report Database.
Topics: Adverse Drug Reaction Reporting Systems; Antirheumatic Agents; Bone Marrow Diseases; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Humans; Interleukin-6; Japan; Methotrexate; Neoplasms; Odds Ratio; Time Factors; Tuberculosis; Tumor Necrosis Factor-alpha | 2018 |
Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity.
Topics: Adalimumab; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Drug-Related Side Effects and Adverse Reactions; Male; Methotrexate; Pancreas; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2018 |
Working Through the Paradox of Methotrexate Toxicity.
Topics: Drug-Related Side Effects and Adverse Reactions; Exanthema; Female; Humans; Methotrexate | 2018 |
Low Persistence Rates in Patients With Rheumatoid Arthritis Treated With Triple Therapy and Adverse Drug Events Associated With Sulfasalazine.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxychloroquine; Male; Medication Adherence; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Treatment Outcome; Tumor Necrosis Factor Inhibitors | 2019 |
Adverse consequences of low-dose methotrexate medication errors: data from French poison control and pharmacovigilance centers.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Databases, Factual; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; France; Humans; Logistic Models; Male; Medication Errors; Methotrexate; Middle Aged; Multivariate Analysis; Pharmacovigilance; Poison Control Centers; Risk Assessment; Sex Factors; Survival Rate | 2019 |
"Methotrexate and NSAIDs in rheumatoid arthritis-Confirmation of a known NSAIDs adverse effect rather than a dangerous combination".
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate | 2018 |
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment.
Topics: Animals; Brain; Cell Differentiation; Cell Lineage; Cognitive Dysfunction; Disease Models, Animal; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Mice; Microglia; Myelin Sheath; Nerve Fibers, Myelinated; Neurogenesis; Neuroglia; Neurons; Oligodendroglia; White Matter | 2019 |
The effect of asparaginase therapy on methotrexate toxicity and efficacy in children with acute lymphoblastic leukemia.
Topics: Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2019 |
Prevalence of methotrexate intolerance among patients with rheumatoid arthritis using the Arabic version of the methotrexate intolerance severity score.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prevalence; Reproducibility of Results; Saudi Arabia; Surveys and Questionnaires; Translating | 2019 |
Bleeding erosions in a man with psoriasis.
Topics: Adult; Antidotes; Drug-Related Side Effects and Adverse Reactions; Early Diagnosis; Hemorrhage; Humans; Immunosuppressive Agents; Leucovorin; Male; Methotrexate; Mucous Membrane; Pancytopenia; Psoriasis; Skin; Treatment Outcome; Withholding Treatment | 2020 |
Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disability Evaluation; Drug Substitution; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Health Status; Humans; Hydroxychloroquine; Logistic Models; Male; Methotrexate; Middle Aged; Sulfasalazine; Treatment Failure; Treatment Outcome | 2013 |
Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis.
Topics: Animals; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Feces; Kidney; Liver; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; Tissue Distribution | 2014 |
Polymorphisms in genes involved in the mechanism of action of methotrexate: are they associated with outcome in rheumatoid arthritis patients?
Topics: Adult; Arthritis, Rheumatoid; Biomarkers, Pharmacological; Cyclin D1; Drug-Related Side Effects and Adverse Reactions; Genetic Association Studies; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Single Nucleotide; Tetrahydrofolate Dehydrogenase; Treatment Outcome | 2014 |
Systems level metabolic phenotype of methotrexate administration in the context of non-alcoholic steatohepatitis in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Energy Metabolism; Folic Acid; Liver; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methotrexate; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats, Sprague-Dawley; Tissue Distribution | 2014 |
Developing a list of high-alert medications for patients with chronic diseases.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Amiodarone; Analgesics, Opioid; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Cytostatic Agents; Digoxin; Dronedarone; Drug-Related Side Effects and Adverse Reactions; Eplerenone; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Insulin; Methotrexate; Mineralocorticoid Receptor Antagonists; Platelet Aggregation Inhibitors; Sodium Potassium Chloride Symporter Inhibitors; Spironolactone | 2014 |
Genetic Determinants of Methotrexate Toxicity in Tunisian Patients with Rheumatoid Arthritis: A Study of Polymorphisms Involved in the MTX Metabolic Pathway.
Topics: Adult; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Female; Ferredoxin-NADP Reductase; Genotype; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Tunisia | 2016 |
Summaries of safety labeling changes approved by FDA-Boxed warnings highlights October-December 2015.
Topics: Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; United States; United States Food and Drug Administration | 2016 |
Letter to the editor in response to the article "Clinical characteristics and risk factors for low dose methotrexate toxicity: a cohort of 28 patients" by Kivity S, Zafrir Y, Loebstein R, Pauzner R, Mouallem M, Mayan H, Autoimmun Rev. 2014 Nov.;13(11):110
Topics: Cohort Studies; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Risk Factors | 2016 |
Methotrexate toxicity-response.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Methotrexate; Polymorphism, Genetic | 2016 |
Evolution After Anti-TNF Discontinuation in Patients With Inflammatory Bowel Disease: A Multicenter Long-Term Follow-Up Study.
Topics: Adalimumab; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antirheumatic Agents; Colitis, Ulcerative; Colon; Constriction, Pathologic; Crohn Disease; Deprescriptions; Disease Progression; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Ileum; Immunologic Factors; Incidence; Inflammatory Bowel Diseases; Infliximab; Male; Mesalamine; Methotrexate; Middle Aged; Proportional Hazards Models; Protective Factors; Recurrence; Remission Induction; Retreatment; Retrospective Studies; Risk Factors; Tumor Necrosis Factor-alpha; Young Adult | 2017 |
High Methotrexate Triglutamate Level Is an Independent Predictor of Adverse Effects in Asian Indian Rheumatoid Arthritis Patients-A Preliminary Study.
Topics: Administration, Oral; Adult; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Drug-Related Side Effects and Adverse Reactions; Erythrocytes; Female; Humans; Male; Methotrexate; Polyglutamic Acid | 2017 |
Drug-induced interstitial pneumonia.
Topics: Amiodarone; Cytotoxins; Drug-Related Side Effects and Adverse Reactions; Humans; Imidazolidines; Lung; Lung Diseases, Interstitial; Methotrexate; Nitrofurantoin; Paraffin; Protein-Tyrosine Kinases; Pulmonary Fibrosis | 2008 |
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Topics: Adolescent; Alleles; Anemia; Antimetabolites, Antineoplastic; Bone Marrow; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Gene Frequency; Genotype; Humans; Kidney; Liver; Lymphoma, Non-Hodgkin; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytopenia; Time Factors | 2009 |
[Toxic effects on the lung: is "pneumonia" caused by drugs?].
Topics: Amiodarone; Anti-Arrhythmia Agents; Anti-Infective Agents, Urinary; Antibiotics, Antineoplastic; Antirheumatic Agents; Bleomycin; Drug-Related Side Effects and Adverse Reactions; Humans; Lung; Lung Diseases; Methotrexate; Nitrofurantoin; Radiography, Thoracic; Risk Factors; Time Factors; Tomography, X-Ray Computed; Tumor Necrosis Factor-alpha | 2009 |
Drug-induced photosensitivity.
Topics: Aminolevulinic Acid; Amiodarone; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Agents; Dermatitis, Photoallergic; Dermatitis, Phototoxic; Dihematoporphyrin Ether; Diuretics; Doxycycline; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Eczema; Furocoumarins; Hematoporphyrin Photoradiation; Humans; Methotrexate; Onycholysis; Photochemotherapy; Photosensitivity Disorders; Photosensitizing Agents; Porphyrins; Psychotropic Drugs; Quinolines; Skin; Skin Aging; Skin Diseases; Skin Neoplasms; Skin Pigmentation; Sulfonamides; Sunscreening Agents; Tetracycline; Ultraviolet Rays; Urticaria; Verteporfin | 2009 |
A pilot study of paternal drug exposure: the Motherisk experience.
Topics: Azathioprine; Breast Feeding; Cohort Studies; Counseling; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lactation; Male; Methotrexate; Paternal Exposure; Pharmaceutical Preparations; Pilot Projects; Pregnancy; Retrospective Studies; Telephone; Teratology | 2010 |
Relationship of the reduced folate carrier gene polymorphism G80A to methotrexate plasma concentration, toxicity, and disease outcome in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Predisposition to Disease; Humans; Male; Membrane Transport Proteins; Methotrexate; Osmolar Concentration; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Reduced Folate Carrier Protein; Treatment Outcome; Young Adult | 2010 |
Efficacy and safety of tacrolimus in 101 consecutive patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Resistance; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Health Status; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Prednisolone; Prospective Studies; Severity of Illness Index; Tacrolimus; Treatment Outcome | 2010 |
Causes of DMARD withdrawal following ADR within 6 months of initiation among Indian rheumatoid arthritis patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxychloroquine; India; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Retrospective Studies; Sulfasalazine; Time Factors | 2012 |
High prevalence of methotrexate intolerance in juvenile idiopathic arthritis: development and validation of a methotrexate intolerance severity score.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Cross-Sectional Studies; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; ROC Curve; Sensitivity and Specificity; Surveys and Questionnaires | 2011 |
A case of acute methotrexate toxicity.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Nausea; Risk Factors; Skin Diseases; Vomiting | 2011 |
Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asian People; Child; Child, Preschool; China; Drug-Related Side Effects and Adverse Reactions; Female; Gene Frequency; Genotype; Haplotypes; Humans; Infant; Linkage Disequilibrium; Logistic Models; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neutropenia; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Skin Diseases; Thrombocytopenia | 2011 |
Safety and effectiveness of adalimumab in Japanese rheumatoid arthritis patients: postmarketing surveillance report of the first 3,000 patients.
Topics: Adalimumab; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Glucocorticoids; Health Status; Humans; Japan; Joints; Lung Diseases; Male; Methotrexate; Middle Aged; Product Surveillance, Postmarketing; Risk Assessment; Severity of Illness Index; Treatment Outcome; Young Adult | 2012 |
Adverse effects of low dose methotrexate in rheumatoid arthritis patients.
Topics: Acute Kidney Injury; Adolescent; Adult; Age Distribution; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Cell Count; Blood Chemical Analysis; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Leukopenia; Liver; Male; Methotrexate; Middle Aged; Pancytopenia; Prognosis; Risk Assessment; ROC Curve; Severity of Illness Index; Sex Distribution; Thrombocytopenia; Young Adult | 2012 |
Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster.
Topics: Animals; Carboplatin; Deoxycytidine; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Fertility; Floxuridine; Gemcitabine; High-Throughput Screening Assays; Humans; Methotrexate; Mitomycin; Models, Animal; Neoplasms; Topotecan | 2012 |
Sustained clinical benefit and tolerability of methotrexate monotherapy after thiopurine therapy in patients with Crohn's disease.
Topics: Adolescent; Adult; Crohn Disease; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Retrospective Studies; Treatment Outcome; Young Adult | 2013 |
Enzymatic cleavage of methotrexate provides a method for prevention of drug toxicity.
Topics: Animals; Antineoplastic Agents; Drug-Related Side Effects and Adverse Reactions; gamma-Glutamyl Hydrolase; Half-Life; Hydrolysis; Leucovorin; Leukemia; Male; Methotrexate; Mice; Pseudomonas; Survival Rate; Time Factors; Weight Loss | 1972 |
MRI in methotrexate-related leukoencephalopathy: Disseminated necrotising leukoencephalopathy in comparison with mild leukoencephalopathy.
Topics: Adolescent; Brain Diseases; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Encephalomyelitis, Acute Disseminated; Female; Follow-Up Studies; Humans; Image Enhancement; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Male; Methotrexate; Radiotherapy, Adjuvant | 2003 |
[Ct findings of drug-induced pneumonitis--characteristic CT findings by histological group and subgroup].
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Antirheumatic Agents; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Female; Humans; Lung; Male; Methotrexate; Middle Aged; Organogold Compounds; Pneumonia; Tomography, X-Ray Computed | 2004 |
Methotrexate-induced encephaloclastic cyst: a complication of intraventricular chemotherapy.
Topics: Adult; Antineoplastic Agents; Brain Diseases; Cysts; Drug-Related Side Effects and Adverse Reactions; Humans; Injections, Intraventricular; Male; Methotrexate | 2006 |
Ancestry and pharmacogenetics of antileukemic drug toxicity.
Topics: Antineoplastic Agents; Child; Drug-Related Side Effects and Adverse Reactions; Genotype; Humans; Methotrexate; Models, Biological; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Racial Groups; Remission Induction | 2007 |
Survey on the use of methotrexate by pediatric rheumatologists in Canada.
Topics: Antirheumatic Agents; Canada; Drug-Related Side Effects and Adverse Reactions; Health Care Surveys; Humans; Methotrexate; Pediatrics; Practice Guidelines as Topic; Practice Patterns, Physicians'; Rheumatology | 2007 |
MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients.
Topics: Adolescent; Adult; Aged; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Rate; Treatment Outcome | 2007 |
Therapy of acute lymphoblastic leukaemia in childhood: effects on the nervous system.
Topics: Asparaginase; Blood-Brain Barrier; Brain Diseases; Cyclophosphamide; Cytosine; Drug-Related Side Effects and Adverse Reactions; Humans; Leukemia, Lymphoid; Methotrexate; Peripheral Nervous System Diseases; Seizures; Vincristine | 1980 |
Interim report: National Registry of possible Drug-induced Ocular Side Effects.
Topics: Contact Lenses; Drug-Related Side Effects and Adverse Reactions; Eye Diseases; Fluorouracil; Humans; Ibuprofen; Methotrexate; Neomycin; Practolol; Registries; Sterilization; Tamoxifen; Timolol; United States; United States Food and Drug Administration | 1980 |
Non-surgical abortion: who's for methotrexate?
Topics: Abortifacient Agents; Abortion, Induced; Drug-Related Side Effects and Adverse Reactions; Federal Government; Female; Government; Government Regulation; Human Experimentation; Humans; Methods; Methotrexate; Mifepristone; Misoprostol; Pharmaceutical Preparations; Physicians; Pregnancy; Pregnant Women; Professional Competence; Risk; Risk Assessment; Social Control, Formal; United Kingdom; United States; United States Food and Drug Administration | 1995 |
[Effects of drugs on the liver. A review illustrated with 3 clinical cases].
Topics: Acetaminophen; Adult; Aged; Androgens; Chemical and Drug Induced Liver Injury; Denmark; Disulfiram; Drug-Related Side Effects and Adverse Reactions; Female; Halothane; Humans; Male; Methotrexate; Middle Aged; Sulfamethizole | 1994 |
A methodology for finding optimal dosage levels in multi-drug treatment interactions.
Topics: Algorithms; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Confidence Intervals; Cyclophosphamide; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Drug Therapy, Computer-Assisted; Drug-Related Side Effects and Adverse Reactions; Imidazoles; Leukemia L1210; Methotrexate; Mice; Models, Biological; Pharmaceutical Preparations; Proportional Hazards Models; Regression Analysis; Survival Rate | 1994 |
The abortion cocktail.
Topics: Abortion, Induced; Drug-Related Side Effects and Adverse Reactions; Ethics Committees; Ethics Committees, Research; Federal Government; Government; Government Regulation; Human Experimentation; Humans; Methotrexate; Mifepristone; Misoprostol; Pharmaceutical Preparations; Pregnancy; Pregnant Women; Research Design; Research Personnel; Risk; Risk Assessment; Scientific Misconduct; Social Control, Formal | 1996 |
Acute skin reactions in postoperative breast cancer patients receiving radiotherapy plus adjuvant chemotherapy.
Topics: Breast Neoplasms; Cobalt Radioisotopes; Cyclophosphamide; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Radioisotope Teletherapy; Radiotherapy; Radiotherapy, High-Energy; Skin Diseases | 1978 |
[Conservative treatment of lung cancer].
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Lung Neoplasms; Male; Methotrexate; Radioisotope Teletherapy; Radiotherapy Dosage; Ukraine; Vinblastine | 1975 |
Liver disease caused by medicinal agents.
Topics: Adrenal Cortex Hormones; Analgesics; Chemical and Drug Induced Liver Injury; Cholestasis; Contraceptive Agents; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Halothane; Humans; Isoniazid; Jaundice; Liver; Liver Cirrhosis; Metabolism, Inborn Errors; Methotrexate; Methoxyflurane; Methyldopa; Necrosis; Novobiocin | 1975 |
[Drug-induced pulmonary diseases: diagnostic, therapeutic and prognostic aspects. Apropos of 10 personal case reports].
Topics: Adrenal Cortex Hormones; Adult; Aged; Amiodarone; Ampicillin; Antihypertensive Agents; Benzothiadiazines; Bleomycin; Bronchoalveolar Lavage Fluid; Cyclophosphamide; Diuretics; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lung Diseases; Male; Methotrexate; Middle Aged; Phenytoin; Prognosis; Sodium Chloride Symporter Inhibitors; Sulindac; Thiamphenicol | 1992 |
Iatrogenic drug toxicity.
Topics: Acetaminophen; Age Factors; Amphotericin B; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Hemolysis; Humans; Isoniazid; Kidney Diseases; Methotrexate; Pharmaceutical Preparations; Probability; Time Factors | 1985 |
[Fatal therapeutic complications].
Topics: Adult; Aged; Anesthesia, Local; Anti-Bacterial Agents; Anticoagulants; Blood Group Incompatibility; Cardiac Catheterization; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Female; Glucocorticoids; Humans; Intubation; Male; Medication Errors; Methotrexate; Middle Aged; Monoamine Oxidase Inhibitors; Phenylbutazone; Tranquilizing Agents; Vaccination; Vinblastine | 1969 |
The child with acute leukemia.
Topics: Age Factors; Asparaginase; Chickenpox; Child, Preschool; Counseling; Cyclophosphamide; Cytarabine; Cytomegalovirus Infections; Daunorubicin; Drug-Related Side Effects and Adverse Reactions; Humans; Injections, Spinal; Leukemia; Mercaptopurine; Methotrexate; Patient Care Planning; Pediatrics; Physician-Patient Relations; Prednisone; Prognosis; Sex Factors; Vincristine | 1974 |
Five-drug combination chemotherapy for disseminated adenocarcinoma.
Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Ovarian Neoplasms; Parotid Neoplasms; Prednisone; Time Factors; Vincristine | 1972 |
[Drug-induced hepatopathies].
Topics: Adult; Age Factors; Bilirubin; Cell Membrane; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Fatty Liver; Female; Halothane; Humans; Infant, Newborn; Liver; Liver Cirrhosis; Male; Methotrexate; Microsomes, Liver; Pharmaceutical Preparations; Pregnancy; Tetracycline | 1974 |
Pulmonary complications of drug therapy.
Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Busulfan; Child; Drug-Related Side Effects and Adverse Reactions; Female; Hexamethonium Compounds; Humans; Hydrochlorothiazide; Lung Diseases; Male; Mecamylamine; Methotrexate; Methysergide; Middle Aged; Nitrofurantoin; Penicillins; Phenytoin; Pleural Effusion; Pneumonia, Pneumocystis; Procainamide; Pulmonary Edema; Pulmonary Fibrosis; Radiography; Sulfadimethoxine | 1970 |