Page last updated: 2024-08-25

methotrexate and Acute Symptom Flare

methotrexate has been researched along with Acute Symptom Flare in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (31.82)24.3611
2020's15 (68.18)2.80

Authors

AuthorsStudies
Haavardsholm, EA; Lillegraven, S; Paulshus Sundlisæter, N1
Baker, KF; Isaacs, JD; Pratt, AG1
Haas, JP; Hügle, B; Krumrey-Langkammerer, M1
de Jong, PHP; Looijen, AEM; van der Helm-van Mil, AHM; van Mulligen, E1
Almeida, B; Bale, P; Foell, D; Gilmour, K; Heard, C; Holzinger, D; Palman, J; Ralph, E; Robinson, E; Roth, J; Sumner, EJ; Ursu, S; Wallace, C; Wedderburn, LR1
Bennett, R; Botson, JK; Chamberlain, J; Kenney, HM; LaMoreaux, B; Obermeyer, K; Peloso, PM; Peterson, J; Ramanathan, S; Song, Y; Tesser, JRP; Weinblatt, ME; Xin, Y; Zhao, L1
Botson, JK; Chamberlain, J; Grewal, S; La, D; LaMoreaux, B; LoCicero, K; Majjhoo, A; Obermeyer, K; Ong, S; Parikh, N; Peterson, J; Saag, K; Sainati, S; Tesser, JRP; Verma, S; Weinblatt, ME; Xin, Y1
Benvenuti, F; Doria, A; Gatto, M; Iaccarino, L; Larosa, M; Montesso, G; Saccon, F; Zen, M1
Choi, Y; Kim, MJ; Lee, EB; Park, JK; Song, YW; Winthrop, K1
de Jong, PHP; Hazes, JM; van der Helm-van Mil, A; van Mulligen, E; Weel, AE1
Ando, M; Asai, N; Asai, S; Fujibayashi, T; Hanabayashi, M; Hattori, Y; Hayashi, M; Hirano, Y; Ishiguro, N; Ishikawa, H; Kanayama, Y; Kato, T; Kobayakawa, T; Kojima, T; Kuwatsuka, Y; Matsumoto, T; Nishiume, T; Shioura, T; Sobue, Y; Suzuki, M; Takahashi, N; Takemoto, T; Yabe, Y; Yoshioka, Y1
Bolhuis, T; Broeder, ND; den Broeder, A; Marsman, D; van den Hoogen, F; van der Maas, A1
Bennett, C; Chen, S; Hannon, CW; Lima, HC; McCourt, C1
Dovrish, Z; Erez, D; Levy, Y; Natour, A; Shoenfeld, Y; Tayer-Shifman, OE1
Aga, AB; Bakland, G; Fremstad, H; Haavardsholm, EA; Hansen, IJW; Hansen, IM; Haukeland, H; Høili, CA; Kvien, TK; Lexberg, Å; Lillegraven, S; Ljoså, MA; Madland, TM; Moholt, E; Olsen, IC; Paulshus Sundlisæter, N; Sexton, J; Solomon, DH; Spada, C; Uhlig, T; van der Heijde, D1
Abud-Mendoza, C; Alexeeva, E; Bandeira, M; Brunner, HI; Chasnyk, VG; Del Rocio Maldonado Velázquez, M; Emminger, W; Foeldvari, I; Gilmer, KE; Horneff, G; Joos, R; Keltsev, V; Kim, L; Kingsbury, DJ; Lamberth, SL; Lauwerys, BR; Leu, JH; Lovell, DJ; Loza, MJ; Martini, A; Minden, K; Nikishina, I; Panaviene, V; Reiff, A; Rubio-Pérez, N; Ruperto, N; Silverman, ED; Smolewska, E; Sztajnbok, F; Tzaribachev, N; van Royen-Kerkhof, A; Xu, Z1
Baert, FJ; Benninga, MA; Caenepeel, P; D'Haens, GR; De Vos, M; Hoekman, DR; Hommes, DW; Stibbe, JA; Vergauwe, P; Vermeire, SA1
Andersen, K; Bartlett, SJ; Bykerk, VP; Cummings, RW; DiCarlo, E; Donlin, LT; Figgie, MP; Goodman, SM; Hoang, A; McNamara, M; Mirza, S; Orange, DE; Szymonifka, J1
Allaart, CF; Bekkering, PW; Boehringer, S; Brederije, ICJ; Brinkman, DMC; Hissink Muller, P; Koopman-Keemink, Y; Kuijpers, TW; Schonenberg-Meinema, D; Ten Cate, R; van den Berg, JM; van den Bosch, WB; Van Rossum, M; van Suijlekom-Smit, LWA1
Aldredge, L; Armstrong, AW; Yamauchi, PS1
de Jong, PH; de Sonnaville, PB; Gerards, AH; Grillet, BA; Hazes, JM; Kuijper, TM; Luime, JJ; Tchetverikov, I; van Krugten, MV; van Zeben, D; Weel, AE1
Nishioka, H; Shimizu, H1

Reviews

3 review(s) available for methotrexate and Acute Symptom Flare

ArticleYear
Interventions for cutaneous disease in systemic lupus erythematosus.
    The Cochrane database of systematic reviews, 2021, 03-09, Volume: 3

    Topics: Age of Onset; Azathioprine; Bias; Biological Factors; Chloroquine; Cosmetic Techniques; Cyclosporine; Dermatologic Agents; Exanthema; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Systemic; Male; Medicine, Chinese Traditional; Methotrexate; Placebos; Quality of Life; Randomized Controlled Trials as Topic; Skin Diseases; Symptom Flare Up

2021
Clinical experience with biologic treatment in resistant eosinophilic fasciitis: Case reports and review of the literature.
    Medicine, 2021, Apr-02, Volume: 100, Issue:13

    Topics: Azathioprine; Biological Products; Biopsy; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Eosinophilia; Fascia; Fasciitis; Female; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Male; Methotrexate; Middle Aged; Prednisone; Rituximab; Symptom Flare Up; Treatment Outcome

2021
Managing Patients With Psoriasis in the Busy Clinic: Practical Tips for Health Care Practitioners.
    Journal of cutaneous medicine and surgery, 2016, Volume: 20, Issue:3

    Topics: Acitretin; Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Cyclosporine; Disease Progression; Humans; Immunosuppressive Agents; Insurance, Health, Reimbursement; Keratolytic Agents; Medication Adherence; Methotrexate; Psoriasis; Symptom Flare Up; Thalidomide

2016

Trials

8 trial(s) available for methotrexate and Acute Symptom Flare

ArticleYear
A Randomized, Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled Gout Receiving Pegloticase: Primary Efficacy and Safety Findings.
    Arthritis & rheumatology (Hoboken, N.J.), 2023, Volume: 75, Issue:2

    Topics: Adult; Anaphylaxis; Arthritis, Gouty; Double-Blind Method; Gout; Gout Suppressants; Humans; Methotrexate; Polyethylene Glycols; Symptom Flare Up; Treatment Outcome; Uric Acid

2023
Effect of short-term methotrexate discontinuation on rheumatoid arthritis disease activity: post-hoc analysis of two randomized trials.
    Clinical rheumatology, 2020, Volume: 39, Issue:2

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Deprescriptions; Drug Administration Schedule; Humans; Methotrexate; Symptom Flare Up

2020
Tapering towards DMARD-free remission in established rheumatoid arthritis: 2-year results of the TARA trial.
    Annals of the rheumatic diseases, 2020, Volume: 79, Issue:9

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Severity of Illness Index; Single-Blind Method; Symptom Flare Up; Time Factors; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Withholding Treatment

2020
Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial.
    JAMA, 2021, 05-04, Volume: 325, Issue:17

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Hydroxychloroquine; Leflunomide; Male; Methotrexate; Middle Aged; Radiography; Sulfasalazine; Symptom Flare Up; Ultrasonography

2021
Subcutaneous golimumab for children with active polyarticular-course juvenile idiopathic arthritis: results of a multicentre, double-blind, randomised-withdrawal trial.
    Annals of the rheumatic diseases, 2018, Volume: 77, Issue:1

    Topics: Adolescent; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis; Arthritis, Juvenile; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Injections, Subcutaneous; Male; Methotrexate; Remission Induction; Symptom Flare Up; Treatment Outcome

2018
Long-term Outcome of Early Combined Immunosuppression Versus Conventional Management in Newly Diagnosed Crohn's Disease.
    Journal of Crohn's & colitis, 2018, Apr-27, Volume: 12, Issue:5

    Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Biological Products; Colonoscopy; Crohn Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Hospitalization; Humans; Immunosuppressive Agents; Infliximab; Intestinal Fistula; Intestinal Mucosa; Male; Mercaptopurine; Methotrexate; Retrospective Studies; Symptom Flare Up; Time Factors; Tumor Necrosis Factor-alpha; Wound Healing; Young Adult

2018
Treat to target (drug-free) inactive disease in DMARD-naive juvenile idiopathic arthritis: 24-month clinical outcomes of a three-armed randomised trial.
    Annals of the rheumatic diseases, 2019, Volume: 78, Issue:1

    Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Blood Sedimentation; Child; Child, Preschool; Drug Therapy, Combination; Etanercept; Female; Humans; Induction Chemotherapy; Male; Methotrexate; Prednisolone; Severity of Illness Index; Single-Blind Method; Sulfasalazine; Symptom Flare Up; Time Factors; Treatment Outcome

2019
Tapering conventional synthetic DMARDs in patients with early arthritis in sustained remission: 2-year follow-up of the tREACH trial.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:12

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Humans; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Remission Induction; Symptom Flare Up; Time Factors

2016

Other Studies

11 other study(ies) available for methotrexate and Acute Symptom Flare

ArticleYear
Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs and Disease Flare in Patients With Rheumatoid Arthritis-Reply.
    JAMA, 2021, 09-07, Volume: 326, Issue:9

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Symptom Flare Up

2021
Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs and Disease Flare in Patients With Rheumatoid Arthritis.
    JAMA, 2021, 09-07, Volume: 326, Issue:9

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Symptom Flare Up

2021
Infection with SARS-CoV-2 causes flares in patients with juvenile idiopathic arthritis in remission or inactive disease on medication.
    Pediatric rheumatology online journal, 2021, Nov-29, Volume: 19, Issue:1

    Topics: Adolescent; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Juvenile; Azetidines; Blood Sedimentation; C-Reactive Protein; Child; COVID-19; Etanercept; Female; Humans; Male; Methotrexate; Purines; Pyrazoles; Remission Induction; SARS-CoV-2; Sulfonamides; Symptom Flare Up; Uveitis

2021
Tapering subcutaneous methotrexate causes more disease flares compared with tapering oral administration in established rheumatoid arthritis patients.
    Rheumatology (Oxford, England), 2022, 08-03, Volume: 61, Issue:8

    Topics: Administration, Oral; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Injections, Subcutaneous; Methotrexate; Symptom Flare Up

2022
Use of MRP8/14 in clinical practice as a predictor of outcome after methotrexate withdrawal in patients with juvenile idiopathic arthritis.
    Clinical rheumatology, 2022, Volume: 41, Issue:9

    Topics: Antirheumatic Agents; Arthritis, Juvenile; Biomarkers; Humans; Methotrexate; Symptom Flare Up; Treatment Outcome

2022
A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an
    Arthritis research & therapy, 2022, 08-25, Volume: 24, Issue:1

    Topics: Gout; Gout Suppressants; Humans; Male; Methotrexate; Polyethylene Glycols; Symptom Flare Up; Treatment Outcome; Urate Oxidase; Uric Acid

2022
Prevalence and predictors of flare after immunosuppressant discontinuation in patients with systemic lupus erythematosus in remission.
    Rheumatology (Oxford, England), 2020, 07-01, Volume: 59, Issue:7

    Topics: Adult; Antimalarials; Antirheumatic Agents; Azathioprine; Cyclosporine; Deprescriptions; Female; Humans; Hydroxychloroquine; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Maintenance Chemotherapy; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Proportional Hazards Models; Protective Factors; Recurrence; Remission Induction; Risk Factors; Symptom Flare Up; Time Factors

2020
Predictors of disease flare after discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab.
    Joint bone spine, 2020, Volume: 87, Issue:6

    Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combination; Humans; Japan; Male; Methotrexate; Prospective Studies; Symptom Flare Up; Treatment Outcome

2020
Effect of add-on methotrexate in polymyalgia rheumatica patients flaring on glucocorticoids tapering: a retrospective study.
    Rheumatology international, 2021, Volume: 41, Issue:3

    Topics: Antirheumatic Agents; Case-Control Studies; Female; Glucocorticoids; Humans; Male; Methotrexate; Polymyalgia Rheumatica; Retrospective Studies; Symptom Flare Up; Treatment Outcome

2021
Flares in Patients with Rheumatoid Arthritis after Total Hip and Total Knee Arthroplasty: Rates, Characteristics, and Risk Factors.
    The Journal of rheumatology, 2018, Volume: 45, Issue:5

    Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Biological Products; Female; Follow-Up Studies; Glucocorticoids; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Multivariate Analysis; Patient Reported Outcome Measures; Prospective Studies; Risk Factors; Self Report; Severity of Illness Index; Surveys and Questionnaires; Symptom Flare Up; Tertiary Care Centers

2018
Successful treatment with tocilizumab for refractory scleritis associated with relapsing polychondritis.
    Scandinavian journal of rheumatology, 2017, Volume: 46, Issue:5

    Topics: Antibodies, Monoclonal, Humanized; Drug Administration Schedule; Drug Resistance; Elastic Cartilage; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Methotrexate; Middle Aged; Polychondritis, Relapsing; Receptors, Interleukin-6; Scleritis; Symptom Flare Up; Treatment Outcome

2017