Page last updated: 2024-08-25

methotrexate and Acute Lymphoid Leukemia

methotrexate has been researched along with Acute Lymphoid Leukemia in 1531 studies

Research

Studies (1,531)

TimeframeStudies, this research(%)All Research%
pre-199083 (5.42)18.7374
1990's468 (30.57)18.2507
2000's446 (29.13)29.6817
2010's400 (26.13)24.3611
2020's134 (8.75)2.80

Authors

AuthorsStudies
Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ1
Araki, R; Fujiki, T; Ikawa, Y; Kuroda, R; Maeba, H; Mase, S; Nishimura, R; Noguchi, K; Wada, T; Yachie, A1
Astorquizaga, L; Cheistwer, A; Font, D; Marin, F; Palmieri, F1
Al-Salami, H; Goločorbin-Kon, S; Lazarević, S; Mikov, M; Mooranian, A; Rajšić, I; Vukmirović, S; Đanić, M1
Duarte, FB; Lima, TT; Nóbrega, PR; Rodrigues, PGB1
Blomgren, A; Hansson, K; Heldrup, J; Isaksson, A; Orrling, H; Pronk, CJ; Schliamser, G1
Hasegawa, D; Hosoya, Y; Kuroko, Y; Manabe, A; Yoshihara, H1
McNeer, JL; Schmiegelow, K1
Hamada, S; Hokama, N; Hyakuna, N; Nakamura, K; Nakanishi, K; Shiohira, H1
Aguilar Martínez, JC; Campos Gonzaga, L; García Martínez, A; Mateos Millán, D1
Arunkumar, G; Kaur, H; Paul, SFD; Ramalingam, R; Scott, JX; Sneha, LM; Srinivasan, A1
Advani, AS; Aldoss, I; Baer, MR; Bhave, RR; Erba, HP; Fang, M; Harvey, RC; Klisovic, RB; Litzow, MR; Moseley, A; O'Dwyer, KM; Othus, M; Park, JH; Sharon, E; Stock, W; Stone, RM; Wieduwilt, MJ; Willman, CL; Wood, BL1
Akaihata, M; Hori, T; Miyata, K; Okumura, A; Shimomura, Y1
Als-Nielsen, B; Anastasopoulou, S; Banerjee, J; Eriksson, MA; Harila-Saari, A; Helenius, M; Heyman, MM; Johannsdottir, IM; Jonsson, OG; MacGregor, S; Mateos, MK; Mayoh, C; Mikkel, S; Myrberg, IH; Nielsen, RL; Niinimäki, R; Ranta, S; Schmiegelow, K; Taskinen, M; Vaitkeviciene, G; Warnqvist, A; Wolthers, B1
Kong, XY; Li, M; Wang, SM2
Khera, S; Negi, V; Sharma, G; Shaw, SC1
Fellah, S; Gandy, K; Hudson, MM; Jacola, LM; Krull, KR; Phillips, N; Pui, CH; Reddick, WE; Scoggins, MA; Sitaram, R; van der Plas, E1
Kaczmarska, A; Lejman, M; Śliwa-Tytko, P; Zawitkowska, J1
Chaudhry, QU; Ghafoor, T; Hussain, F; Mahmood, SK; Rehman, J1
Lee, SHR; Schmiegelow, K; Toksvang, LN; Yang, JJ1
Boufrikha, W; Boukhriss, S; Cheffaï, A; Laatiri, MA; Rakez, R1
Jin, RM; Li, K; Shen, YQ; Wang, ZJ; Wu, XY; Xu, WF; Zhou, F1
Faria, MJ; Fernanda, T; Rita, D; Rui, B1
Bojalil-Álvarez, L; Cortés, JE; Fernández-Gutiérrez, JA; García-Villaseñor, E; Murrieta-Álvarez, I; Reyes-Cisneros, OA; Ruiz-Argüelles, GJ; Ruiz-Delgado, GJ; Sánchez-Bonilla, D1
Boyunağa, Ö; Karamercan, S; Kaya, Z; Koçak, Ü; Topuz Türkcan, B; Uyar Göcün, P; Yazol, M1
Borges, KS; Cruzeiro, GAV; Junior, HLR; Laranjeira, ABA; Moreno, DA; Ramalho, FS; Rego, EM; Salomão, KB; Scrideli, CA; Silva, CLA; Tone, LG; Yunes, JA1
Ding, MM; Huang, ZZ; Jia, YP; Liu, J; Lu, AD; Qin, J; Wu, J; Zhang, LP; Zuo, YX1
Alvarado, Y; Ferrajoli, A; Garcia-Manero, G; Garris, R; Huang, X; Jabbour, E; Jain, N; Kadia, TM; Kantarjian, H; Konopleva, M; Macaron, W; Patel, KP; Ravandi, F; Short, NJ; Thompson, PA; Yilmaz, M1
Calvo, C; Delgado, EF; Ruggeri, RA1
Fujisawa, H; Hao, A; Komaki, S; Matsumoto, H; Mitsui, Y; Narukawa, K; Shirasugi, Y; Takahashi, T1
Dabaja, BS; Fang, PQ; Nasr, L; Short, NJ; Wu, SY1
Antolinez, YV; Colunga-Pedraza, JE; Colunga-Pedraza, PR; Fierro-Saenz, S; González-Llano, O; Lopez-Reyna, IG; Montes-Tapia, FF1
Cohen, IJ; Sadeh, M; Toledano, H1
Bernhardt, MB; Brown, AL; Gramatges, MM; Harris, RD; Lupo, PJ; Rabin, KR; Schafer, ES; Scheurer, ME; Taylor, OA; Zobeck, MC1
Al Sabahi, A; Albiroty, K1
Chen, C; Li, X; Qi, J; Yongjing, W1
Bernhardt, MB; Kamdar, KY; Lupo, PJ; Rabin, KR; Scheurer, ME; Zobeck, M1
Chen, H; Deng, QM; Huang, S; Li, F; Liu, XX; Zhang, JM; Zhu, XX1
Chen, YC; Hsiao, CC; Hsieh, HY; Huang, LT; Huang, YC; Lo, WS; Sheen, JM; Wang, SC1
Fang, Q; Hao, Q; Huang, X; Mi, Y; Wang, J; Wang, Y; Wei, H; Zhang, P1
Attarbaschi, A; Barbaric, D; Bodmer, N; Cario, G; Colombini, A; Conter, V; Dalla-Pozza, L; Elitzur, S; Heilmann, J; Izraeli, S; Mann, G; Möricke, A; Niggli, F; Rizzari, C; Schrappe, M; Silvestri, D; Stary, J; Valsecchi, MG; Vieth, S; Zapotocka, E; Zimmermann, M1
Chan, A; Ciurea, SO; Doh, J; Griffin, SP; Jeyakumar, D; Kongtim, P; Lee, BJ; O'Brien, S1
Li, L; Liu, WE; Ma, Y; Zhang, LF; Zhang, XC1
Alvarado, Y; Dabaja, B; Garcia-Manero, G; Garris, R; Haddad, FG; Jabbour, E; Jacob, J; Jain, N; Jorgensen, J; Kadia, T; Kanagal-Shamanna, R; Kantarjian, H; Kebriaei, P; Khouri, I; Loghavi, S; O'Brien, S; Paul, S; Ravandi, F; Sasaki, K; Short, NJ; Yilmaz, M1
Curra, M; Dalla Costa, T; de Araújo, BV; de Oliveira Henz, P; Gregianin, LJ; Martins, M; Pinhatti, AV1
Howell, K; Romanick, M; Vasquez, MR1
Chen, Y; Cheng, Y; Liu, M; Wang, M; Zhao, L; Zhao, M1
Gebhard, A; Lilienthal, P; Metzler, M; Rauh, M; Sager, S; Schmiegelow, K; Toksvang, LN; Zierk, J1
Ambrosino, N; Awoniyi, O; Bernhardt, MB; Board, SG; Castellino, SM; Chavana, A; DeGroote, NP; Joshi, V; Miller, TP; O'Brien, MM; Pommert, L; Poweleit, EA; Ramsey, LB; Schafer, ES; Taylor, ZL; Ugboh, N1
Chen, S; Gong, J; Jia, Y; Jian, C; Jian, J; Li, Z; Wang, H; Wang, T; Wang, X; Wang, Z; Xiang, T; Zhang, Y; Zhou, Y1
Cheng, Z; Wang, S; Xie, F; Yang, M; Yin, Q1
Chen, X; Dai, Y; Li, X; Meng, M; Sun, H; Yang, Z; Zhou, S1
Canevarolo, RR; Cury, NM; Yunes, JA1
Watanabe, K1
Benesch, M; Egger, M; Flaschberger, S; Gorkiewicz, G; Karastaneva, A; Kohlmaier, B; Lackner, H; Marterer, R; Seidel, M; Sperl, D; Strenger, V; Trobisch, A; Urban, C1
Kok, NTM; Ligthart-Beukhof, AC; van de Wetering, MD1
de Jonge, R; Fiocco, M; Heil, SG; Oosterom, N; Pieters, R; Smith, DEC; Tissing, WJE; van den Heuvel-Eibrink, MM; van Zelst, BD1
Gaynon, PS1
Bhojwani, D; Carroll, WL; E, S; Evans, WE; Goodings, C; Li, C; Seibel, NL; Xu, H; Yang, JJ; Yang, W; Zhang, H; Zhao, X1
Chen, K; Li, H; Li, J; Wang, Y; Xu, Q1
Alexandrov, LB; Brady, SW; Cai, J; Cheng, C; Ding, L; Dong, L; Downing, JR; Du, L; Easton, J; Edmonson, MN; Flasch, DA; Hagiwara, K; Li, B; Li, H; Li, Y; Lin, TN; Liu, Y; Ma, X; Mulder, HL; Myers, MA; Pui, CH; Raphael, BJ; Rusch, M; Shao, Y; Shen, S; Sioson, E; Sun, H; Sun, HY; Sun, L; Szlachta, K; Tang, J; Tian, L; Wang, N; Wang, T; Xu, K; Yang, F; Yang, JJ; Yang, L; Zhang, H; Zhang, J; Zhang, Y; Zhao, J; Zhou, BS; Zhou, X; Zhu, X1
Climent, F; Ivan, I; Mercadal, S1
Bah, M; Becerra, E; Berumen-Segura, L; Escobar-Cabrera, J; Garay, E; García-Alcocer, G; Hernández-Pérez, A; Mendoza-Santiago, A1
Karppinen, S; Lohi, O; Vihola, M1
Jabbour, EJ; Kadia, TM; Kantarjian, HM; Rausch, CR1
Attarbaschi, A; Bader, P; Barisone, E; Basso, G; Biondi, A; Cario, G; Caterina Putti, M; Cazzaniga, G; Colombini, A; Conter, V; Flotho, C; Kuhlen, M; Lang, P; Lauten, M; Linderkamp, C; Lo Nigro, L; Locatelli, F; Mann, G; Möricke, A; Niggli, F; Panzer-Grümayer, R; Parasole, R; Peters, C; Rizzari, C; Schrappe, M; Suttorp, M; Valsecchi, MG; Zimmermann, M1
Hogan, WJ; Litzow, M; Schram, S; Sierzchulski, AG; Truong, H1
Ibrahim, HM; Jamari, H; James, RJ; Noorizhab, MNF; Razali, RH; Salleh, MZ; Teh, KH; Teh, LK1
Bhojwani, D; Dabagh, S; David, H; Doan, A; Young, S1
Ahmed, MU; Al-Mamun, MMA; Apu, MNH; Biswas, SK; Hasnat, A; Islam, MR; Islam, MS; Kabir, AL; Nahar, Z; Nahid, NA; Zahra, FT1
Hidaka, Y; Kurata, T; Matsuoka, D; Morita, D; Morota, H; Nakazawa, Y; Natsume, T; Okura, E; Saito, S; Sakashita, K; Shigemura, T; Tanaka, M; Uchida, E; Watanabe, T1
Fustino, NJ; Juhl, K; Leister, J1
Cortez Neto, L; Leite, RA; Matas, CG; Matas, SLA; Odone Filho, V; Santos, NP; Vosgrau, JS1
Campana, D; Cheng, C; Coustan-Smith, E; Lins, MM; Lucena-Silva, N; Pedrosa, A; Pedrosa, F; Pedrosa, M; Ramos, AML; Ribeiro, RC; Rivera, GK; Vinhas, E; Zhou, Y1
Ma, Y; Yang, XY; Zhang, H; Zhang, WP; Zhang, YX1
Alten, J; Behrens, YL; Bergmann, AK; Buchmann, S; Cario, G; Cazzaniga, G; Davenport, CF; Ebersold, J; Fazio, G; Göhring, G; Hagedorn, M; Hofmann, W; Lentes, J; Möricke, A; Schieck, M; Schlegelberger, B; Schrappe, M; Stanulla, M; Steinemann, D; Thomay, K1
Abedi, M; Esmaeili, A; Rahgozar, S1
Abboud, MR; Chahrour, M; El-Khoury, H; El-Solh, H; Ghanem, KM; Hamideh, D; Muwakkit, SA; Saab, R; Saifi, O; Tamim, H; Tarek, N1
García-Hernández, MH; Godina-González, S; Medina-Rosales, MN1
Dokmanovic, L; Gasic, V; Janic, D; Kotur, N; Krstovski, N; Lazic, J; Milosevic, G; Pavlovic, S; Ristivojevic, B; Stankovic, B; Zukic, B1
Abrahamsson, J; Grell, K; Grosjean, M; Gupta, R; Hjalgrim, LL; Jiang, C; Jónsson, ÓG; Kanerva, J; Lund, B; Moriyama, T; Nersting, J; Nielsen, RL; Nielsen, SN; Overgaard, U; Pruunsild, K; Quist-Paulsen, P; Schmiegelow, K; Tulstrup, M; Vaitkeviciene, G; Wolthers, BO; Yang, JJ; Zhang, H1
Burke, MJ; Egelund, TA; Katzenstein, HM; Liberio, N; Ng, JS; Pommert, L; Siver, MJ1
Li, M; Sun, LL; Wang, SM; Wu, WS; Yan, D1
Bafna, V; Bartakke, S; Pawar, A; Sajith, M2
Clevers, H; de Jonge, R; Driehuis, E; Heil, SG; Jansen, G; Kolders, S; Lin, M; Muller, IB; Oosterom, N; Pieters, R; van den Heuvel-Eibrink, MM1
Chae, H; Cho, B; Choi, SH; Chung, NG; Kim, M; Kim, SK; Kim, Y; Lee, JW1
Kong, XY; Li, M; Sun, LL; Wang, SM; Yan, D1
Ariffin, H; Lim, CH; Rajagopal, R; Ramli, N; Seow, P; Tan, LK1
Assanasen, C; Gramatges, MM; Khalfe, Y; Lucari, B; Mullikin, D; Ranch, D; Schafer, ES; Scheurer, ME; Zobeck, MC1
Berg, SL; Bernhardt, MB; Cheng, WS; Foster, JH; Mangum, R; Schafer, ES1
Asano, T; Iguchi, A; Miyasho, T1
Björgvinsdóttir, H; Bohnstedt, C; Degn, M; Grell, K; Hafsteinsdottir, S; Heyman, M; Hoogerbrugge, P; Schmiegelow, K; Taskinen, M; Zeller, B; Østergaard, A1
Beaumont, AL; Suner, L1
Díez-Martín, JL; Domingo-González, A; Landete, E; Monsalvo, S; Osorio, S1
Bernar, B; Crazzolara, R; Griesmacher, A; Kapelari, K; Kropshofer, G; Müller, T; Scholl-Bürgi, S1
Dhingra, H; Kalra, M; Mahajan, A1
Curra, M; Evangelista, JMC; Ferreira, MBC; Gabriel, AF; Gregianin, L; Martins, MAT; Martins, MD; Roesler, R; Schmidt, TR; Valer, JB1
Elloumi, M; Frikha, F; Frikha, R; Jemaa, MB; Kamoun, H; Keskes, L; Rebai, T; Turki, I1
Brice, A; Chatelut, E; Faguer, S; Gallais, F; Lafont, T; Marsili, S; Oberic, L; Puisset, F; Tavitian, S1
Choi, L; Ho, RH; Schulte, RR; Stein, CM; Utreja, N; Van Driest, SL1
Gangopadhyay, D; Radhakrishnan, V1
MacDonald, T; Price, V; Whiley, AC1
Aladle, DA; El Marghany, AB; El Menshawy, N; Sarhan, MM1
Christensen, M; De Pietri, S; Frandsen, TL; Grell, K; Müller, K; Rathe, M1
Autry, RJ; Bonten, EJ; Cheng, C; Crews, KR; Diouf, B; Evans, WE; Lopez-Lopez, E; McCorkle, JR; Mullighan, CG; Panetta, JC; Paugh, SW; Pei, D; Pounds, S; Pui, CH; Relling, MV; Roberts, KG; Shi, L; Smart, B; Smith, C; Yang, W1
Apak, H; Celkan, T; Koka, A; Özdemir, N; Sunamak, EÇ; Yantiri, L1
Al-Sheikh, A; Alshamaseen, D; Farhad, R; Yousef, AM1
Chen, RJ; Cui, X; He, J; Lian, LJ; Lin, B; Lin, XD; Sun, W; Wang, Z; Ye, WJ1
Alsdorf, WH; Bokemeyer, C; Frenzel, C; Karagiannis, P; Langebrake, C1
Banerjee, P; Cheung, YT; Glass, JO; Hudson, MM; Kesler, SR; Krull, KR; Liu, W; Ogg, RJ; Phillips, NS; Pui, CH; Reddick, WE; Robison, LL; Scoggins, MA; Srivastava, D1
Candoni, A; Canichella, M; Cavalli, M; Chiaretti, S; Conter, V; D'Aloisio, M; De Propris, MS; Elia, L; Fazi, P; Foà, R; Guarini, A; Luppi, M; Martino, B; Messina, M; Moleti, ML; Piciocchi, A; Starza, ID; Testi, AM; Vignetti, M; Vitale, A1
Chen, K; Wang, L; Xu, Q1
Fujiwara, K; Ishida, H; Kanamitsu, K; Kanzaki, H; Kitamura, Y; Sendo, T; Shimada, A; Tatebe, Y; Tsukahara, H; Washio, K1
Chen, MH; Chen, YY; Cheng, Y; Lin, BJ; Liu, MB; Qiu, HQ; Que, WC; Yang, L; Zhuang, Q1
Abe, K; Aono, H; Fushimi, S; Kondo, R; Kume, M; Saito, M; Shibata, K; Takahashi, N; Takahashi, S; Teshima, K1
Baran, J; Embry, L; Hardy, KK; Hullmann, SE; Jacola, LM; Kairalla, JA; Larsen, EC; Noll, RB; Willard, VW; Winick, N1
Alvaro, F; Barbaric, D; Barbaro, PM; Catchpoole, D; Chenevix-Trench, G; Dalla-Pozza, L; George, C; Giles, JE; Kotecha, RS; Lawson, JA; MacGregor, S; Marshall, GM; Mateos, MK; Mayoh, C; Mechinaud, F; Quinn, MCJ; Revesz, T; Sutton, R; Trahair, TN1
Phillips, B; Proudfoot, RH1
Gaipov, A; Issakov, S; Jubaniyazov, B; Saparov, A; Sazonov, V; Tobylbayeva, Z1
Audino, AN; Chung, C; Fernandez Faith, E; Guinipero, T; Ravi, M; Ridpath, A1
Haque, AU; Jabbar, N; Mirza, S; Razi, W; Sadiq, H; Ullah, R1
Hama, A; Matsumoto, K; Sakaguchi, H; Takeuchi, T; Yoshida, N1
Chen, ZB; Ding, CC; Liu, S; Qu, Q; Wang, GQ; Wen, FQ; Zhan, M1
Agrawal, S; Krawczyk, M; Makuch, S; Nowak, M; Pastuch-Gawołek, G; Szeja, W; Wiśniewski, J; Woźniak, M1
Abrahamsson, J; Appell, ML; Grell, K; Hjalgrim, LL; Jónsson, ÓG; Kanerva, J; Lund, B; Nersting, J; Nielsen, SN; Pruunsild, K; Schmiegelow, K; Toksvang, LN; Vaitkeviciene, G1
Billiet, T; D'Hooge, R; Deprez, S; Elens, I; Labarque, V; Lemiere, J; Sleurs, C; Uyttebroeck, A; Van Gool, S1
Cho, HW; Choi, R; Chun, MR; Hyun, JK; Ju, HY; Kim, S; Koo, HH; Lee, JW; Lee, SY; Park, J; Won, H; Yi, ES1
Elloumi, M; Frikha, R; Kamoun, H; Rebai, T1
Athale, U; Bassal, M; Breakey, VR; Gibson, PJ; Gupta, S; Li, Q; Mittmann, N; Patel, S; Pechlivanoglou, P; Pole, JD; Silva, M; Sutradhar, R; Zabih, V1
Abou Dalle, I; Bazarbachi, A; Bidikian, AH; El-Cheikh, J; Hourani, R1
Abrahamsson, J; Andrés-Jensen, L; Frandsen, TL; Grell, K; Griškevičius, L; Harila-Saari, A; Joelsson, J; Jónsson, ÓG; Mogensen, SS; Nersting, J; Nielsen, SN; Niinimäki, R; Overgaard, UM; Quist-Paulsen, P; Rank, CU; Schmiegelow, K; Toft, N; Toksvang, LN; Vaitkevičienė, G1
Aarnivala, H; Banerjee, J; Harila-Saari, A; Niinimäki, R; Pokka, T; Vepsäläinen, K1
Caldito, EG; Elsebaie, M; Pescatore, JM1
Bashari, MH; Idjradinata, P; Kaspers, GJL; Rakhmilla, LE; Raspati, H; Reniarti, L; Sari, NM; Supriyadi, E; Suryawan, N; Susanah, S; Zazuli, Z1
Chen, F; Chen, J; Gong, Y; Li, X; Luo, L; Ma, Y; Shi, C; Sun, Y; Wang, L; Xu, Z1
Bai, H; Liu, WH; Mao, DF; Ren, LW; Wang, ZH; Wu, T; Xue, F; Yu, LL1
Algarra-Algarra, JL; Gómez-Catalán, I; Hernández-Fernández, F; Ibañez-García, Á; Marín-Sánchez, A; Martínez-Fernández, G; Montoya-Morcillo, MC; Romero-Macías, JR1
Al Achkar, W; Aljapawe, A; As'sad, M; Liehr, T; Wafa, A1
Huang, RS; Marable, M; Rudin, S1
Albertsen, BK; De Pietri, S; Frandsen, TL; Grell, K; Lähteenmäki, PM; Nersting, J; Nielsen, SN; Nilsson, D; Nystad, TA; Rosthøj, S; Schmiegelow, K; Toksvang, LN; Wehner, PS1
Al-Mahayri, ZN; Ali, BR; Patrinos, GP1
Bekker-Mendez, C; Del Carmen Pinto-Escalante, D; Del Carmen Rodríguez-Zepeda, M; Flores-Lujano, J; Flores-Villegas, LV; Fragoso, JM; García-Escalante, MG; González-Montalvo, PM; Guerra-Castillo, FX; Gutiérrez-Juárez, EI; Hidalgo-Miranda, A; Jiménez-Hernández, E; Jiménez-Morales, S; Leal, YA; Mejía-Aranguré, JM; Núñez-Enríquez, JC; Núñez-Villegas, NN; Pantoja-Guillen, F; Peñaloza-Gonzalez, JG; Pérez-Saldivar, ML; Ramírez-Bello, J; Ramírez-Florencio, M; Ramos-Cervantes, MT; Torres-Escalante, JL1
Chen, ZP; Cui, L; Gao, C; Li, WJ; Li, ZG; Liu, SG; Wang, JX; Wu, MY; Yue, ZX; Zhang, RD; Zhang, YY; Zhao, XX; Zheng, HY1
Cario, G; Conter, V; Dagdan, E; Hinze, L; Junk, S; Kratz, CP; Möricke, A; Schrappe, M; Stanulla, M; Zimmermann, M1
Bernhardt, MB1
Chang, YH; Chao, YH; Chiou, YH; Hsu, MC; Peng, CT; Wu, HP; Wu, KH; Yu, MS1
de Jonge, R; den Hoed, MAH; García-Orad, A; Gutierrez-Camino, A; Heil, SG; Lopez-Lopez, E; Martin-Guerrero, I; Oosterom, N; Pieters, R; Pluijm, SMF; Tissing, WJE; van den Heuvel-Eibrink, MM1
Guo, HM; Li, F; Ma, JM; Meng, L; Yin, DD; Zhou, XL1
de la Maya, MD; de Murillo, SG; Gervasini, G; Jiménez, M; Vagace, JM2
Adams, G; Apperley, JF; Brannigan, E; Davies, F; Fernando, F; Innes, AJ; Marchesi, JR; Mullish, BH; Pavlů, J1
Eckert, C; Izraeli, S1
Forster, VJ; McDonnell, A; McKay, JA; Theobald, R1
Mescher, C; Slungaard, A1
Berger, A; Bernhardt, MB; Felix-Ukwu, F; Reichert, K; Schafer, ES1
Alyea, EP; Artz, A; Boyer, MW; Chen, YB; DiPersio, JF; Gergis, U; Glavin, F; Ho, VT; Holter, J; Horwitz, ME; Jagasia, MH; Johnston, L; Kim, HT; Levine, JD; Lewis, ID; Martin, PJ; Maziarz, RT; McGuirk, J; Patnaik, MM; Pidala, JA; Porter, DL; Reshef, R; Ritz, J; Rybka, W; Safah, H; Shaughnessy, PJ; Shea, TC; Soiffer, RJ; Stiff, PJ; Szer, J; Vusirikala, M; Westervelt, P1
Cohen, IJ5
Lee, SHR; Yang, JJ1
Akbaraly, T; Deneux, V; Haouy, S; Leboucq, N; Saumet, L; Sirvent, N1
Basso, G; Buldini, B; Cazzaniga, G; Ceppi, F; Colombini, A; Conter, V; Douyon, L; Gagné, V; Krajinovic, M; Parasole, R; Quintin, CJ1
Kanfi, A; Samanta, D; Willis, E1
Alexander, TC; Allen, AR; Anderson, J; Carr, H; Carter, G; Groves, T; Kiffer, F; Simecka, CM; Wang, J1
Gong, B; Gong, X; Gu, R; Li, Y; Lin, D; Liu, B; Liu, K; Liu, Y; Mi, Y; Qiu, S; Wang, H; Wang, J; Wang, Y; Wei, H; Wei, S; Zhang, G; Zhao, X; Zhou, C1
Christensen, JR; Edvardsen, E; Kanellopoulos, A; Kongerud, J; Lund, MB; Myrdal, OH; Ruud, E; Sikkeland, LI1
Sun, LL; Wang, SM; Wu, WS; Yan, D; Zeng, WX2
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Ohnuma, T; Takemura, Y1
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Greeff, MC; Macdougall, LG; McElligott, SE; Poole, JE; Ross, E1
Berry, DH; Caldwell, D; Spence, GT; Williams, J; Zolten, AJ1
Graf, N; Pees, HW; Radtke, H; Schwamborn, J1
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Iwai, A; Komazawa, M; Maeda, H; Nagata, K; Ninomiya, T; Nishikawa, K; Ohmiya, A; Ohta, M; Sato, J; Tsuda, Y1
Amadori, S; Guglielmi, C; Mandelli, F; Martelli, M; Papa, G2
Balcar-Boroń, A; Krzyzanowski, M; Ozyński, T; Pilecki, O; Szadujkis-Szadurski, L; Wysocki, M1
Balcar-Boroń, A; Krzyzanowski, M; Nowaczyk-Michalak, A; Ozyński, T; Szadujkis-Szadurski, L; Wysocki, M1
Muller-Runkel, R; Vijayakumar, S1
Crist, WM; Crom, WR; Evans, WE; Groom, S; McLeod, HL; Relling, MV; Rivera, GK; Rodman, JH; Silverstein, K1
Fujieda, M; Hisakawa, H; Kubota, H; Kurashige, T; Matsumoto, K; Wakiguchi, H1
Forio, I; Giralt, J; Olive, T; Ortega, JJ; Salvador, L; Verges, R1
Asami, K; Sasazaki, Y; Utsumi, J1
Akiyama, Y; Asato, R; Ito, M; Konishi, J; Kubota, M; Mikawa, H; Miki, Y; Okumura, R1
Andrew, M; Barr, RD; Cairney, AE; DeVeber, LL; Halton, J; Pai, KM; Whitton, AC1
Bartolucci, AA; Gordon, DS; Martelo, OJ; Omura, GA; Raney, M; Vogler, WR1
Abromowitch, M; Bowman, WP; Dahl, GV; Dodge, RK; Evans, WE; Hancock, ML; Ochs, J; Pui, CH; Simone, JV; Williams, DL1
Gelber, RD; Kahn, CM; Sallan, SE; Tarbell, NJ; Waber, DP1
Bancillon, A; Baruchel, A; Bergeron, C; Leblanc, T; Lejars, O; Lepage, E; Leverger, G; Perel, Y; Schaison, G; Sommelet, D1
Bailey, CC; Chessells, JM; Richards, S1
Andersen, JW; Bennett, JM; Cassileth, PA; Hoagland, HC; Mazza, JJ; O'Connell, MC; Paietta, E; Wiernik, P1
Alessandrino, EP; Bacigalupo, A; Bernasconi, C; Carella, AM; Ficarra, F; Lazzarino, M; Locatelli, F; Morra, E; Pagnucco, G; Resegotti, L1
Grexa, E; Kajtár, P; Kardos, M1
Eguchi, M; Furukawa, T; Kurosawa, H; Sakakibara, H; Sugita, K1
Alfawaz, IM; Matar, KM; Najjar, TA1
Essell, JH; Halvorson, RD; Harman, GS; Johnson, RA; Rubinsak, JR; Snyder, MJ; Thompson, JM1
Wang, ZH; Yu, ZL1
Henningsson, S; Jakobson, AM; Kreuger, A; Moe, PJ; Mortimer, O; Seidel, H1
Laitinen, J; Lanning, M; Vainionpää, L1
Armata, J; Balwierz, W; Bogusławska-Jaworska, J; Chybicka, A; Cyklis, R; Derulska, D; Duczmal, B; Jackowska, T; Jakowicka, M; Rokicka-Milewska, R1
Bogdanić, V; Grgić-Markulin, L; Jakić-Razumović, J; Kalenić, S; Labar, B; Mrsić, M; Nemet, D; Presecki, V; Vrtar, M; Vujasinović, S1
Langlands, K; Ludlam, CA; Parker, AC; Russell, L; Turner, ML; Watson, HG1
Fairclough, D; Mulhern, RK; Ochs, J2
García Zueco, JC; López Gómez, L; Martín Guerrero, Y; Torres Gómez, M1
Harada, M; Murakawa, M; Niho, Y; Okamura, T; Otsuka, T; Shibuya, T1
Cosolo, W; Siderov, J; Zalcberg, J1
Butturini, A; Gale, RP1
Miyachi, H; Ohnuma, T; Sekiguchi, S; Takemura, Y1
Beaulieu, D; Rosenblatt, DS; Shuster, JJ; Vuchich, MJ; Whitehead, VM; Witte, A1
Chan, TK; Chiu, E; Ho, FC; Liang, R; Lie, A; Loke, SL; Todd, D1
Maca, RD1
Bertino, JR; Lin, JT; Niedzwiecki, D; Schweitzer, BI; Steinherz, P; Tan, C; Tao, Y; Tong, WP; Trippett, TM1
Drigan, R; Gelber, RD; Spirito, A1
Bowman, WP; Buchanan, GR; Jacaruso, D; Kamen, BA; Roach, ES; Rollins, N; Winick, NJ1
Bayle, C; Brugières, L; Caillaud, JM; Flamant, F; Hartmann, O; Kalifa, C; Lemerle, J; Patte, C; Valteau-Couanet, D1
Bratina, G; Conter, V; D'Angelo, P; Jankovic, M; Masera, G; Rovelli, A; Uderzo, C1
Hidaka, S; Hiraoka, A; Kobayashi, M; Matsunashi, T; Nakamura, H; Tejima, H; Tominaga, N; Yoshida, H; Yoshida, S; Yoshimura, M1
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Sommelet, D1
Rumiantsev, AG; Samochatova, EV1
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Lanning, M; Myllylä, V; Risteli, J; Risteli, L; Vainionpää, L1
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Blattner, SR; Clavell, LA; Cohen, HJ; Donahue, K; Donnelly, M; Gelber, RD; Niemeyer, CM; Sallan, SE; Tarbell, NJ1
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Holowiecki, J; Kachel, L; Lawniczek, T; Pajak, J; Rudzka, E1
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Chevallier, B; Leneveu, A; Négre, V; Roux, A1
Beck, D; de Crousaz, H; Deonna, T; Janzer, RC; Miklossy, J; von der Weid, NX1
Bleyer, WA; Coccia, PF; Finklestein, JZ; Hammond, GD; Littman, PS; Lukens, JN; Miller, DR; Nickerson, HJ; Sather, HN; Siegel, SE1
Budman, DR; Cuttner, J; Davey, F; Henderson, ES; Lee, EJ; Mayer, RJ; Mick, R; Paciucci, PA; Sobol, R; Weiss, RB1
Inoue, N; Kakishita, E; Kanemaru, A; Kohsaki, M; Konya, H; Miyazaki, E; Okamoto, T; Takemoto, Y; Tamura, S1
Matsuhisa, T; Miyoshi, K; Moriwaki, S; Motoi, M; Naruse, R; Okabe, K; Sakamoto, S; Shimokawa, T; Toki, H; Urayama, H1
Albertsson-Wikland, K; Lannering, B; Màrky, I; Mellander, L1
Eden, OB; Lilleyman, JS; Peto, J; Richards, S; Shaw, MP1
Dhondt, JL; Farriaux, JP; Hayte, JM; Mazingue, F; Millot, F; Taret, S1
Breithaupt, H; Hartmann, R; Henze, G; Hepp, R; Wolfrom, C1
Brouwers, P; Poplack, D1
Christensen, B; Refsum, H; Ueland, PM1
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Yin, Z1
De Boben, M; Diedrich, H; Freund, M; Ganser, A; Heil, G; Henke, M; Heyll, A; Hiddemann, W; Knauf, U; Koch, P1
Fengler, R; Henze, G; Reiter, A; Riehm, H; Ritter, J1
Goebel, U; Graubner, U; Haas, RJ; Janka-Schaub, GE; Juergens, H; Spaar, HJ; Winkler, K1
Dörffel, W; Malke, H; Reimann, M; Reuter, G; Zintl, F1
Bührer, C; Henze, G; Hofmann, J; Reiter, A; Riehm, H; Schellong, G1
Bode, U; Fengler, R; Hartmann, R; Henze, G; Janka, G; Jürgens, H; Riehm, H1
Evans, WE; Kavanagh, RL; Ochs, J; Rivera, GK; Rodman, JH; Sunderland, M; Yalowich, J1
Balter, R; Borgna-Pignatti, C; Caraballo, R; Colamaria, V; Dalla Bernardina, B; Marradi, P; Mazza, C; Procacci, C1
Bartsch, CH; Gadner, H; Martins da Cunha, AC1
Amess, J; Barbui, T; Barnett, MJ; Bassan, R; Battista, R; Gregory, W; Horton, M; Lim, J; Oza, A; Rohatiner, AZ1
Buchanan, G; Crist, W; Freeman, AI; Ochs, J; Pollock, BH; Rivera, GK1
Howes, A; Mullenix, PJ; Schunior, A; Tarbell, NJ; Tassinari, MS; Zengel, AE1
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Atogami, S; Kuriyama, K; Maeda, T; Miyazaki, Y; Murata, K; Nagai, K; Nonaka, H; Satoh, T; Tokunaga, S; Yanagisako, T1
Komatsu, K1
Chung, D; Ferrazzini, G; Griesbrecht, E; Klein, J; Koren, G; Sulh, H1
Kaneko, Y; Kawai, S; Kondo, M; Mimaya, J; Tonouchi, T; Toyoda, Y; Ueda, R1
Nachman, J1
Harris, MB; Krance, RA; Newman, EM; Pinkel, D; Ravindranath, Y; Testi, AM; Villacorte, DG1
Harada, M; Hayashi, S; Kubota, T; Nagafuchi, S; Niho, Y; Ohtsuka, T; Okamura, T; Shibuya, T1
Belasco, JB; Luery, N; Scher, C1
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Barnes, J; Eden, OB; Hann, IM; Pinkerton, CR1
Balsom, W; Bleyer, WA; Constine, L; Fallavollita, J; Heyn, R; Meadows, A; Miller, D; Ortega, J; Robison, L; Sitarz, A1
Pulczynska, MK; Schmiegelow, K1
Katz, ER; Rubenstein, CL; Varni, JW1
Albo, VC; Hammond, GD; Leikin, SL; Miller, DR; Palmer, NF; Sather, HN1
Bolanowska, WE; Freitag, CM; Jones, CS; Kalman, TI; McGuire, JJ; Russell, CA1
Foot, AB; Mott, MG; Oakhill, A1
Bakker, MA; Bökkerink, JP; Damen, FJ; De Abreu, RA; Hulscher, MW1
Borsi, JD; Moe, PJ; Romslo, I; Sagen, E2
Atwood, J; Aur, RJ; Hanna, M; Sabbah, R; Sackey, K; Willoughby, S1
Dinklage, D; Gioia, G; Paccia, J; Sallan, SE; Sherman, B; Sollee, N; Tarbell, NJ; Urion, DK; Waber, DP1
Cotes, PM; Hellebostad, M; Marstrander, J; Refsum, HE; Slørdahl, SH1
Pulczynska, M; Schmiegelow, K1
Cavanagh, NP; Chessells, JM; Cox, TC; Jannoun, L; Kendall, B; Richards, S1
Evans, WE; Pui, CH; Schell, MJ1
Endresen, L; Lie, SO; Rugstad, HE; Stokke, O; Storm-Mathisen, I1
Ferrazini, G; Giesbrecht, E; Greenberg, M; Kapelushnik, J; Klein, J; Koren, G; Langevin, AM; Soldin, S; Sulh, H1
Morgan, H; Mott, M; Oakhill, A; Verity, CM1
Bader-Meunier, B; Dommergues, JP; Garel, D; Venencie, PY1
Bruunshuus, I; Schmiegelow, K1
Happle, R; Koopman, RJ1
Abromowitch, M; Fairclough, D1
Eden, OB1
Hermans, J; Zwaan, FE1
Giesbrecht, E; Greenberg, M; Koren, G; Langevin, AM; Olivieri, N; Zipursky, A1
Iwata, N; Maekawa, T; Omine, M; Yamauchi, H1
Carbone, G; Leone, G; Marra, R; Massaro, AR; Pagano, L; Storti, S1
Mealey, J; Shapiro, S1
Charlesworth, M; Ede, GM; Gawler, J; Green, CR; Jamal, GA; Patel, P; Prior, PF; Stevenson, JF; Thakkar, CM; Tucker, J1
Imashuku, S; Mizutani, A; Morimoto, A; Morioka, Y; Nakajima, T; Sakata, K; Shimizu, Y; Todo, S; Tsunamoto, K1
Lennard, L; Lilleyman, JS1
Greenberg, M; Klein, J; Koren, G; Soldin, SJ; Solh, H1
Hejl, M; Pulczynska, MK; Schmiegelow, K; Schrøder, H1
Kumar, L; Raghunath Rao, D; Rajkumar, T; Sagar, TG; Shanta, V; Usha Devi, CJ1
Lifschitz, CH; Mahoney, DH1
Deville, A; Etienne, MC; Manassero, J; Milano, G; Thyss, A1
Huismans, DR; Leyva, A; Pieters, R; Veerman, AJ1
Bertino, JR; Chang, YM; Li, WW; Lin, J; Pizzorno, G1
Eden, OB; Shaw, NJ1
Albo, VC; Hammond, GD; Leikin, SL; Miller, DR; Sather, H1
Meyers, P; Redner, A; Steinherz, P; Tan, C; Wollner, N1
Ochs, JJ1
Acebedo Lerzundi, G; Javier Manchón, G; Montagut Dueso, JM; Olivé Oliveras, T; Ortega Aramburu, JJ; Torán Fuentes, N1
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Bleyer, WA; Coccia, PF; Hammond, GD; Lukens, JN; Miller, DR; Sather, HN; Siegel, SE1
Steinherz, PG1
Behrendt, H; Hermans, J; Schuwirth, C; van der Does-van den Berg, A; van Leeuwen, EF; van Wering, ER; Verkes, RJ1
Jansen, G; Kathmann, I; Rademaker, BC; Rijksen, G; Schornagel, JH; Westerhof, GR1
Bodensteiner, JB; Gay, CT; Nitschke, R; Sexauer, C; Wilson, D1
Cohen, G; Gitter, KA; Stewart, MW1
Fondevila Carlos, G; Milone Gustavo, A; Santiago, P1
Adair, S; Camitta, B; Casper, J; Civin, C; Graham, M; Lauer, S; Leventhal, B; Mahoney, D; Munoz, L; Shuster, JJ1
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Etienne, MC; Grelier, P; Milano, G; Paquis, P; Roche, JL; Schneider, M; Thyss, A1
Andrew, M; Barr, RD; Desai, SJ; deVeber, LL; Pai, MK1
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Pieters, R; Veerman, AJ1
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Abdalla, A; Badrawy, F; Hamza, R; Khalifa, A1

Reviews

111 review(s) available for methotrexate and Acute Lymphoid Leukemia

ArticleYear
High-dose Methotrexate-induced Acral Erythema in Two Pediatric Patients With Acute Lymphoblastic Leukemia: A 17 Pediatric Case Series of Methotrexate-induced Acral Erythema.
    Journal of pediatric hematology/oncology, 2021, Nov-01, Volume: 43, Issue:8

    Topics: Antimetabolites, Antineoplastic; Child; Erythema; Foot Dermatoses; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2021
Management of CNS Disease in Pediatric Acute Lymphoblastic Leukemia.
    Current hematologic malignancy reports, 2022, Volume: 17, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Central Nervous System Neoplasms; Child; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies

2022
Neurotoxicity Associated with Treatment of Acute Lymphoblastic Leukemia Chemotherapy and Immunotherapy.
    International journal of molecular sciences, 2022, May-15, Volume: 23, Issue:10

    Topics: Asparaginase; Child; Drug-Related Side Effects and Adverse Reactions; Humans; Immunologic Factors; Immunotherapy, Adoptive; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations.
    Leukemia, 2022, Volume: 36, Issue:7

    Topics: Humans; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Thioguanine

2022
Optimum Methotrexate Exposure in Patients With Suspected or Confirmed CNS Invasive Hematological Malignancies: A Systematic Critical Review.
    Therapeutic drug monitoring, 2023, 06-01, Volume: 45, Issue:3

    Topics: Adult; Central Nervous System Neoplasms; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2023
Central Nervous System Prophylaxis and Treatment in Acute Leukemias.
    Current treatment options in oncology, 2022, Volume: 23, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cytarabine; Humans; Leukemia, Myeloid, Acute; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
A Comprehensive Review of Neuropsychologic Studies Supports the Concept That Adequate Folinic Acid Rescue Prevents Post Methotrexate Neurotoxicity.
    Journal of pediatric hematology/oncology, 2023, 01-01, Volume: 45, Issue:1

    Topics: Bone Neoplasms; Child; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Intrathecal methotrexate induced myelopathy, rare yet serious complication: A case report and review of the literature.
    Current research in translational medicine, 2021, Volume: 69, Issue:3

    Topics: Adult; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases

2021
The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment.
    Genomics, proteomics & bioinformatics, 2017, Volume: 15, Issue:2

    Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Female; Humans; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2017
Pharmacogenomics in pediatric acute lymphoblastic leukemia: promises and limitations.
    Pharmacogenomics, 2017, Volume: 18, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Methotrexate; Pharmacogenomic Testing; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2017
Pharmacogenomics in acute lymphoblastic leukemia.
    Best practice & research. Clinical haematology, 2017, Volume: 30, Issue:3

    Topics: Antimetabolites, Antineoplastic; Asparaginase; Child; Clinical Trials as Topic; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Humans; Mercaptopurine; Methotrexate; Methyltransferases; Molecular Targeted Therapy; Pharmacogenetics; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrophosphatases; Signal Transduction; Vincristine

2017
Glucarpidase treatment for methotrexate intoxication: a case report and review of the literature.
    The Netherlands journal of medicine, 2018, Volume: 76, Issue:1

    Topics: Acute Kidney Injury; Adult; Antimetabolites, Antineoplastic; gamma-Glutamyl Hydrolase; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins

2018
The Use of Ommaya Reservoirs to Deliver Central Nervous System-Directed Chemotherapy in Childhood Acute Lymphoblastic Leukaemia.
    Paediatric drugs, 2018, Volume: 20, Issue:4

    Topics: Antineoplastic Agents; Catheters, Indwelling; Child, Preschool; Drug Delivery Systems; Humans; Infusions, Intraventricular; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2018
The role of genetic polymorphisms in the thymidylate synthase (TYMS) gene in methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.
    Pharmacogenetics and genomics, 2018, Volume: 28, Issue:10

    Topics: Alleles; Child; Child, Preschool; Female; Gene Expression Regulation; Genetic Association Studies; Genotype; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Tandem Repeat Sequences; Thymidylate Synthase

2018
Clinical Implications of Methotrexate Pharmacogenetics in Childhood Acute Lymphoblastic Leukaemia.
    Current drug metabolism, 2019, Volume: 20, Issue:4

    Topics: Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2019
Methotrexate Disposition in Pediatric Patients with Acute Lymphoblastic Leukemia: What Have We Learnt From the Genetic Variants of Drug Transporters.
    Current pharmaceutical design, 2019, Volume: 25, Issue:6

    Topics: Antimetabolites, Antineoplastic; ATP-Binding Cassette Transporters; Child; Humans; Methotrexate; Multidrug Resistance-Associated Protein 2; Organic Anion Transporters; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2019
The effect of leucovorin rescue therapy on methotrexate-induced oral mucositis in the treatment of paediatric ALL: A systematic review.
    Critical reviews in oncology/hematology, 2019, Volume: 142

    Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Humans; Infant; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Treatment Outcome; Young Adult

2019
Pharmacogenomic approaches for tailored anti-leukemic therapy in children.
    Current medicinal chemistry, 2013, Volume: 20, Issue:17

    Topics: Alkaloids; Antineoplastic Agents; Benzamides; Child; Glucocorticoids; Hepatic Veno-Occlusive Disease; Humans; Imatinib Mesylate; Mercaptopurine; Methotrexate; Nucleotides; Pharmacogenetics; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thioguanine; Vincristine

2013
How long can folinic acid rescue be delayed after high-dose methotrexate without toxicity?
    Pediatric blood & cancer, 2014, Volume: 61, Issue:1

    Topics: Antineoplastic Agents; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B Complex

2014
Pharmacogenetics of methotrexate in acute lymphoblastic leukaemia: why still at the bench level?
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:3

    Topics: Antimetabolites, Antineoplastic; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Genetic; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
Association between reduced folate carrier G80A polymorphism and methotrexate toxicity in childhood acute lymphoblastic leukemia: a meta-analysis.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:12

    Topics: Age Factors; Alleles; Antimetabolites, Antineoplastic; Child; Female; Genotype; Humans; Male; Methotrexate; Odds Ratio; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2014
[Acute lymphoblastic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cyclophosphamide; Dasatinib; Daunorubicin; Doxorubicin; Enzyme Inhibitors; Humans; Imatinib Mesylate; Methotrexate; Middle Aged; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles; Young Adult

2014
Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction.
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:7

    Topics: Antimetabolites, Antineoplastic; Child; Drug Therapy, Combination; Humans; Maintenance Chemotherapy; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors.
    Journal of the National Cancer Institute, 2014, Volume: 106, Issue:8

    Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Attention; Benzhydryl Compounds; Brain Neoplasms; Central Nervous System Stimulants; Child; Child, Preschool; Cognitive Dysfunction; Comorbidity; Cranial Irradiation; Donepezil; Early Intervention, Educational; Education, Special; Head and Neck Neoplasms; Human Growth Hormone; Humans; Indans; Infant; Injections, Spinal; Memory, Short-Term; Methotrexate; Methylphenidate; Modafinil; Neoplasms; Neurosurgical Procedures; Nootropic Agents; Patient Education as Topic; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Quality of Life; Radiotherapy Dosage; Risk Factors; Severity of Illness Index; Sex Factors; Survivors; Thinking; Wakefulness-Promoting Agents; Young Adult

2014
Pharmacogenetics of childhood acute lymphoblastic leukemia.
    Pharmacogenomics, 2014, Volume: 15, Issue:10

    Topics: Child; Child, Preschool; Epigenesis, Genetic; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2014
Improving treatment of children with acute lymphoblastic leukemia in developing countries through technology sharing, collaboration and partnerships.
    Expert review of hematology, 2014, Volume: 7, Issue:5

    Topics: Antimetabolites, Antineoplastic; Child; Developing Countries; Humans; Methotrexate; Neoplasm, Residual; Partnership Practice; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
[Current treatment of pediatric acute lymphoblastic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Child, Preschool; Clinical Trials as Topic; Cytarabine; Dexamethasone; Drug Discovery; Humans; Imatinib Mesylate; Induction Chemotherapy; Mercaptopurine; Methotrexate; Molecular Targeted Therapy; Neoplasm, Residual; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Pyrimidines

2014
Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review.
    Neuroscience and biobehavioral reviews, 2015, Volume: 53

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Clinical Protocols; Cognition; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors

2015
Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:7

    Topics: Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Liver-Specific Organic Anion Transporter 1; Metabolic Networks and Pathways; Methotrexate; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2015
Influence of Cranial Radiotherapy on Outcome in Children With Acute Lymphoblastic Leukemia Treated With Contemporary Therapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016, Mar-20, Volume: 34, Issue:9

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cranial Irradiation; Humans; Infant; Linear Models; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Retrospective Studies; Secondary Prevention; Treatment Outcome

2016
[Influence of cranial radiotherapy on outcome in children with acute lymphoblastic leukemia treated with contemporary therapy].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2016, Volume: 192, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Neoplasms; Child; Child, Preschool; Cranial Irradiation; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome

2016
Minimal residual disease-guided therapy in childhood acute lymphoblastic leukemia.
    Blood, 2017, 04-06, Volume: 129, Issue:14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Cyclophosphamide; Daunorubicin; Humans; Induction Chemotherapy; Male; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine

2017
Treatment of acute lymphoblastic leukemia in children and adolescents: peaks and pitfalls.
    Hematology. American Society of Hematology. Education Program, 2008

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Diploidy; Disease-Free Survival; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Risk Assessment; Survival Rate; Treatment Outcome; Young Adult

2008
Poor-risk high-grade gliomas in three survivors of childhood acute lymphoblastic leukaemia--an overview of causative factors and possible therapeutic options.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009, Volume: 25, Issue:5

    Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Child; Child, Preschool; Cranial Irradiation; Female; Glioma; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy, Adjuvant; Risk Factors; Supratentorial Neoplasms; Survivors; Treatment Outcome

2009
Genomic strategies to improve outcome and individualize therapy in cancer: the paradigm of childhood acute lymphoblastic leukemia.
    Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2009, Volume: 14 Suppl 1

    Topics: Antineoplastic Agents; Child; Genetic Association Studies; Genome-Wide Association Study; Humans; Methotrexate; Pharmacogenetics; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
Cancer research: from folate antagonism to molecular targets.
    Best practice & research. Clinical haematology, 2009, Volume: 22, Issue:4

    Topics: Aminopterin; Folic Acid Antagonists; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2009
Pharmacogenomics of pediatric acute lymphoblastic leukemia.
    Expert opinion on pharmacotherapy, 2010, Volume: 11, Issue:10

    Topics: Child; Cytochrome P-450 CYP3A; Glucocorticoids; Humans; Methotrexate; Methyltransferases; Neoplasm, Residual; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2010
Impact of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on methotrexate-induced toxicities in acute lymphoblastic leukemia: a meta-analysis.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012, Volume: 33, Issue:5

    Topics: Alleles; Antimetabolites, Antineoplastic; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Intracellular disposition of methotrexate in acute lymphoblastic leukemia in children.
    Current drug metabolism, 2012, Volume: 13, Issue:6

    Topics: Antimetabolites, Antineoplastic; Biological Transport; Child; Humans; Mercaptopurine; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
[Feasibility and safety of chemotherapy for acute lymphoblastic leukemia in adolescents and young adults: Interim analysis of JALSG ALL202-U].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2012, Volume: 53, Issue:8

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Asparaginase; Clinical Trials, Phase II as Topic; Feasibility Studies; Female; Humans; Maintenance Chemotherapy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Safety; Young Adult

2012
A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia.
    The pharmacogenomics journal, 2013, Volume: 13, Issue:6

    Topics: Child; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2013
Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoblastic leukemia.
    The Israel Medical Association journal : IMAJ, 2002, Volume: 4, Issue:11

    Topics: Antimetabolites, Antineoplastic; Child; Drug Interactions; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase

2002
Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Mar-15, Volume: 21, Issue:6

    Topics: Antineoplastic Agents; Azacitidine; Child; Child, Preschool; Drug Approval; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neuroblastoma; Osteosarcoma; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; United States; United States Food and Drug Administration; Vindesine

2003
CNS-directed therapy for childhood acute lymphoblastic leukemia: Childhood ALL Collaborative Group overview of 43 randomized trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, May-01, Volume: 21, Issue:9

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Injections, Spinal; Male; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recurrence; Treatment Outcome

2003
[Results and suggestion from comparing between world excellent protocols of childhood acute lymphoblastic leukemia].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2003, Volume: 41, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Cyclophosphamide; Daunorubicin; Humans; Internationality; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Survival Rate; Treatment Outcome; Vincristine

2003
[Resistance mechanisms to Methotrexate].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2003, Volume: 41, Issue:5

    Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2003
Defining the appropriate dosage of folinic acid after high-dose methotrexate for childhood acute lymphatic leukemia that will prevent neurotoxicity without rescuing malignant cells in the central nervous system.
    Journal of pediatric hematology/oncology, 2004, Volume: 26, Issue:3

    Topics: Central Nervous System Neoplasms; Child; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2004
Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia.
    British journal of haematology, 2004, Volume: 125, Issue:4

    Topics: Alkylating Agents; Child; Child, Preschool; Drug Resistance, Multiple; Genetic Variation; Glucocorticoids; Humans; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine; Treatment Outcome

2004
Prevalence of leukoencephalopathy in children treated for acute lymphoblastic leukemia with high-dose methotrexate.
    AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Prospective Studies; Risk Factors

2005
High-dose methotrexate in acute lymphoblastic leukemia: where is the evidence for its continued use?
    Pharmacotherapy, 2005, Volume: 25, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Child; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Skeletal morbidity in childhood acute lymphoblastic leukaemia.
    Clinical endocrinology, 2005, Volume: 63, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Child; Child, Preschool; Female; Glucocorticoids; Homeostasis; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
[Acute encephalopathy during treatment of lymphoblastosis in children].
    Annales de pediatrie, 1976, Dec-02, Volume: 23, Issue:12

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Autopsy; Bone Marrow Examination; Cerebral Infarction; Child, Preschool; Fatal Outcome; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

1976
High-dose methotrexate and/or leucovorin rescue for the treatment of children with lymphoblastic malignancies: do we really know why, when and how?
    Neoplasma, 2005, Volume: 52, Issue:6

    Topics: Antimetabolites, Antineoplastic; Child; Dose-Response Relationship, Drug; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction

2005
Treatment of acute lymphoblastic leukemia.
    The New England journal of medicine, 2006, Jan-12, Volume: 354, Issue:2

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Child; Combined Modality Therapy; Dexamethasone; Gene Expression Profiling; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Assessment; Stem Cell Transplantation; Survival Analysis

2006
Down syndrome and acute lymphoblastic leukaemia.
    British journal of haematology, 2006, Volume: 135, Issue:5

    Topics: Antineoplastic Agents; Child; Child, Preschool; Down Syndrome; Humans; Infant; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Translocation, Genetic; Treatment Outcome

2006
Neurocognitive effects of treatment for childhood cancer.
    Mental retardation and developmental disabilities research reviews, 2006, Volume: 12, Issue:3

    Topics: Antineoplastic Agents; Brain Neoplasms; Child; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Developmental Disabilities; Humans; Injections, Spinal; Intellectual Disability; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2006
Granular acute lymphoblastic leukemia: a case report and literature review.
    American journal of hematology, 2007, Volume: 82, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Cytoplasmic Granules; Dexamethasone; Doxorubicin; Female; Humans; Immunophenotyping; Methotrexate; Middle Aged; Multiple Myeloma; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Treatment Outcome; Vincristine

2007
[Optimal central nervous system directed therapy in childhood acute lymphoblastic leukemia.].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2007, Volume: 45, Issue:5

    Topics: Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Hypergranular acute lymphoblastic leukemia (ALL). Report of a case and review of the literature.
    Annals of hematology, 1993, Volume: 67, Issue:6

    Topics: Adult; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Bleomycin; Bone Marrow; Gene Rearrangement; Genes, Immunoglobulin; Humans; Immunoglobulin Heavy Chains; Male; Methotrexate; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Restriction Mapping; Tegafur

1993
Compliance with oral chemotherapy in childhood lymphoblastic leukaemia.
    Cancer treatment reviews, 1995, Volume: 21, Issue:2

    Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Attitude to Health; Biological Availability; Child; Humans; Mercaptopurine; Methotrexate; Patient Compliance; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone

1995
[A heart transplant in a patient with doxorubicin-induced myocardiopathy as a complication of the treatment of a lymphoma].
    Revista espanola de cardiologia, 1994, Volume: 47, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiomyopathy, Dilated; Cyclophosphamide; Daunorubicin; Doxorubicin; Heart Transplantation; Humans; Male; Methotrexate; Myocardium; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Time Factors; Vincristine

1994
Central nervous system directed therapy in acute lymphoblastic leukaemia.
    Bailliere's clinical haematology, 1994, Volume: 7, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Child; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Growth Disorders; Humans; Injections, Spinal; Leukemic Infiltration; Male; Meninges; Mental Disorders; Methotrexate; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Quality of Life; Radiation Injuries; Risk Factors; Survival Rate; Survivors; Treatment Outcome

1994
Neuropsychological effects of cranial radiation: current knowledge and future directions.
    International journal of radiation oncology, biology, physics, 1995, Feb-15, Volume: 31, Issue:4

    Topics: Adult; Brain Neoplasms; Carcinoma, Small Cell; Child; Cranial Irradiation; Educational Measurement; Forecasting; Humans; Intelligence; Lung Neoplasms; Memory; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage

1995
Adult acute leukemia.
    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 1994, Volume: Suppl

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Burkitt Lymphoma; Clinical Trials as Topic; Combined Modality Therapy; Cytarabine; Humans; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Survival Rate; Treatment Outcome

1994
"Above all do no harm:" horizons in pediatric oncology.
    Current opinion in pediatrics, 1994, Volume: 6, Issue:2

    Topics: Bone Marrow Transplantation; Child; Combined Modality Therapy; Growth Substances; Humans; Leukemia, Myeloid, Acute; Medical Oncology; Mercaptopurine; Methotrexate; Pediatrics; Phenotype; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life; Recurrence; Survival Rate

1994
[Recent views on the use of methotrexate in the treatment of acute lymphoblastic leukemia in childhood].
    Ceskoslovenska pediatrie, 1993, Volume: 48, Issue:12

    Topics: Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1993
Acute myelofibrosis terminating in acute lymphoblastic leukemia: case report and review of the literature.
    American journal of hematology, 1996, Volume: 51, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blast Crisis; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 5; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Progression; Flow Cytometry; Humans; Immunophenotyping; Male; Mercaptopurine; Methotrexate; Neoplastic Stem Cells; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Primary Myelofibrosis; Remission Induction; Vincristine

1996
High-dose methotrexate in the treatment of adult acute lymphoblastic leukemia.
    Annals of hematology, 1996, Volume: 72, Issue:4

    Topics: Adult; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1996
The role of anthracyclines in adult acute lymphoblastic leukaemia.
    Leukemia, 1996, Volume: 10 Suppl 2

    Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Disease-Free Survival; Doxorubicin; Humans; Idarubicin; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Translocation, Genetic

1996
Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia.
    Leukemia & lymphoma, 1996, Volume: 21, Issue:5-6

    Topics: Adult; Antimetabolites, Antineoplastic; Biological Transport; Biotransformation; Carrier Proteins; Child; Chromosomes, Human, Pair 21; Disease Susceptibility; Disease-Free Survival; Down Syndrome; Drug Resistance, Neoplasm; Folic Acid Antagonists; Half-Life; Humans; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Neoplasm Proteins; Neoplastic Stem Cells; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Reduced Folate Carrier Protein; Remission Induction; Tetrahydrofolate Dehydrogenase

1996
Intrathecal methotrexate overdose.
    Acta paediatrica (Oslo, Norway : 1992), 1997, Volume: 86, Issue:4

    Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Child, Preschool; Drug Overdose; Female; Humans; Injections, Spinal; Male; Medication Errors; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Time Factors

1997
Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?
    Leukemia research, 1997, Volume: 21, Issue:5

    Topics: Antimetabolites, Antineoplastic; Child; Disease-Free Survival; Dose-Response Relationship, Drug; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Risk Assessment

1997
Clinical presentation, hematologic features and treatment outcome of childhood acute lymphoblastic leukemia: a review of 73 cases in Hong Kong.
    Hematological oncology, 1997, Volume: 15, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cranial Irradiation; Disease-Free Survival; Female; Hemorrhage; Hepatomegaly; Hong Kong; Humans; Immunophenotyping; Infant; Karyotyping; Life Tables; Male; Methotrexate; Pain; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Retrospective Studies; Splenomegaly; Survival Analysis; Treatment Outcome

1997
Maintenance chemotherapy of acute lymphoblastic leukemia in children.
    Danish medical bulletin, 1998, Volume: 45, Issue:5

    Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1998
Successful treatment of intrathecal methotrexate overdose with folinic acid rescue: a case report.
    Acta paediatrica (Oslo, Norway : 1992), 1999, Volume: 88, Issue:7

    Topics: Antidotes; Antimetabolites, Antineoplastic; Child; Drug Overdose; Humans; Injections, Spinal; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1999
Mechanisms of methotrexate resistance in acute leukemia. Decreased transport and polyglutamylation.
    Advances in experimental medicine and biology, 1999, Volume: 457

    Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; gamma-Glutamyl Hydrolase; Humans; Leukemia, Myeloid, Acute; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1999
Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.
    Leukemia & lymphoma, 1999, Volume: 35, Issue:1-2

    Topics: Antimetabolites, Antineoplastic; Child; Disease Progression; Folic Acid; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Risk Factors

1999
The interaction of 6-mercaptopurine (6-MP) and methotrexate (MTX).
    General pharmacology, 1999, Volume: 33, Issue:4

    Topics: Antimetabolites, Antineoplastic; Child; Drug Interactions; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1999
[Relapse of acute lymphoblastic leukemia as a retro-orbital mass].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1999, Volume: 40, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Methotrexate; Orbital Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence

1999
[Effects of chemotherapy on the changes of histology and function of the ovary].
    Zhonghua fu chan ke za zhi, 1998, Volume: 33, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Daunorubicin; Female; Fluorouracil; Humans; Methotrexate; Ovary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

1998
Optimizing antimetabolite-based chemotherapy for the treatment of childhood acute lymphoblastic leukaemia.
    British journal of haematology, 2000, Volume: 110, Issue:1

    Topics: Antimetabolites, Antineoplastic; Child; Cytarabine; Drug Administration Schedule; Etoposide; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; Thioguanine

2000
Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia.
    British journal of haematology, 2000, Volume: 110, Issue:4

    Topics: Acute Disease; Animals; Child; Drug Administration Schedule; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Leukemia, B-Cell; Leukemia, Myeloid; Leukemia, T-Cell; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2000
High-dose methotrexate in childhood all.
    Pediatric hematology and oncology, 2000, Volume: 17, Issue:8

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Disease-Free Survival; Drug Administration Schedule; Humans; Infusions, Intravenous; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life; Time Factors

2000
Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL).
    Hematology/oncology clinics of North America, 2000, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Central Nervous System Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Germany; Humans; Immunophenotyping; Injections, Spinal; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Models, Theoretical; Multicenter Studies as Topic; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Remission Induction; Risk; Survival Rate; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome

2000
The hyper-CVAD regimen in adult acute lymphocytic leukemia.
    Hematology/oncology clinics of North America, 2000, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Central Nervous System Neoplasms; Child; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dexamethasone; Doxorubicin; Drug Administration Schedule; Granulocyte Colony-Stimulating Factor; Humans; Immunization, Passive; Immunophenotyping; Infusions, Intravenous; Injections, Spinal; Karyotyping; Mercaptopurine; Methotrexate; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk; Rituximab; Survival Analysis; Texas; Treatment Outcome; Vincristine

2000
Improving outcome through two decades in childhood ALL in the Nordic countries: the impact of high-dose methotrexate in the reduction of CNS irradiation. Nordic Society of Pediatric Haematology and Oncology (NOPHO).
    Leukemia, 2000, Volume: 14, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2000
Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature.
    Annals of hematology, 2000, Volume: 79, Issue:12

    Topics: Adult; Female; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Respiratory Distress Syndrome

2000
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone.
    Hematology/oncology clinics of North America, 2001, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Controlled Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Dactinomycin; Doxorubicin; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Multicenter Studies as Topic; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Randomized Controlled Trials as Topic; Recombinant Proteins; Remission Induction; Survival Analysis; Treatment Outcome; Vincristine

2001
Central nervous system involvement in adult acute lymphocytic leukemia.
    Hematology/oncology clinics of North America, 2001, Volume: 15, Issue:1

    Topics: Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Child; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Humans; Injections, Spinal; Leukemic Infiltration; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Risk Factors; Salvage Therapy; Survival Analysis; Treatment Outcome

2001
Long-term outcome of treatment with protocols AL841, AL851, and ALHR88 in children with acute lymphoblastic leukemia: results obtained by the Kyushu-Yamaguchi Children's Cancer Study Group.
    International journal of hematology, 2001, Volume: 73, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Height; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Growth Disorders; Heart Failure; Hematopoietic Stem Cell Transplantation; Humans; Infant; Japan; Male; Methotrexate; Myelodysplastic Syndromes; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Retrospective Studies; Salvage Therapy; Survival Rate; Survivors; Treatment Outcome; Vincristine

2001
Intrathecal chemotherapy with antineoplastic agents in children.
    Paediatric drugs, 2001, Volume: 3, Issue:4

    Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood-Brain Barrier; Cerebellar Neoplasms; Cerebrospinal Fluid; Child; Cytarabine; Humans; Injections, Spinal; Lymphoma; Medulloblastoma; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thiotepa

2001
Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Oct-15, Volume: 19, Issue:20

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Infections; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survival Analysis; Thrombocytopenia; Vincristine

2001
[Advances in the study of acute lymphocytic leukemia treated by large dosage of methotrexate].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 1999, Volume: 20, Issue:2

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1999
Subcutaneous infection with Mycobacterium fortuitum after allogeneic bone marrow transplantation.
    Bone marrow transplantation, 2001, Volume: 28, Issue:7

    Topics: Adult; Bone Marrow Transplantation; Clarithromycin; Combined Modality Therapy; Cyclosporine; Debridement; Drug Therapy, Combination; Female; Graft vs Host Disease; Humans; Immunocompromised Host; Immunosuppressive Agents; Methotrexate; Minocycline; Mycobacterium fortuitum; Mycobacterium Infections, Nontuberculous; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Skin Ulcer; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous

2001
Low relapse rate in children with acute lymphoblastic leukemia after risk-directed therapy.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:9

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Bone Marrow Transplantation; Burkitt Lymphoma; Child; Child, Preschool; Combined Modality Therapy; Daunorubicin; Disease-Free Survival; Female; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Genes, Immunoglobulin; Humans; Immunoglobulin Heavy Chains; Infant; Leukemia-Lymphoma, Adult T-Cell; Life Tables; Male; Methotrexate; Neoplasm, Residual; Polymerase Chain Reaction; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Retrospective Studies; Risk; Survival Analysis; Survival Rate; Treatment Outcome; Vincristine

2001
Continuing therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of methotrexate, 6-mercaptopurine and 6-thioguanine.
    Cancer treatment reviews, 2001, Volume: 27, Issue:6

    Topics: Antineoplastic Agents; Child; Humans; Mercaptopurine; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine

2001
CNS-directed therapy in childhood acute lymphoblastic leukaemia.
    British journal of haematology, 1992, Volume: 82, Issue:1

    Topics: Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy

1992
Disposition of antineoplastic agents in the very young child.
    The British journal of cancer. Supplement, 1992, Volume: 18

    Topics: Age Factors; Antineoplastic Agents; Blood Proteins; Child; Child, Preschool; Doxorubicin; Etoposide; Humans; Infant; Infant, Newborn; Liver; Mercaptopurine; Methotrexate; Neoplasms; Nervous System; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide

1992
[Transient subacute encephalopathy induced by high-dose methotrexate treatment in children with acute lymphoblastic leukemia and malignant lymphoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:11

    Topics: Adolescent; Brain; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Leigh Disease; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1992
[Neurologic complications during chemotherapy of children with acute lymphoid leukemia].
    Orvosi hetilap, 1992, May-03, Volume: 133, Issue:18

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Diseases; Child; Female; Hemiplegia; Humans; Intracranial Embolism and Thrombosis; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1992
[Recent advances in oncology. Acute lymphoblastic leukemia in children].
    Archives francaises de pediatrie, 1991, Volume: 48, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Child, Preschool; Chromosome Deletion; Cytogenetics; Humans; Methotrexate; Philadelphia Chromosome; Ploidies; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Translocation, Genetic

1991
CNS prophylaxis of childhood leukemia: what are the long-term neurological, neuropsychological, and behavioral effects?
    Neuropsychology review, 1991, Volume: 2, Issue:2

    Topics: Brain; Brain Damage, Chronic; Brain Neoplasms; Child; Child Behavior Disorders; Cranial Irradiation; Follow-Up Studies; Humans; Injections, Spinal; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Wechsler Scales

1991
Methotrexate and childhood leukemia.
    Cancer investigation, 1991, Volume: 9, Issue:1

    Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction

1991
Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia.
    Medical and pediatric oncology, 1991, Volume: 19, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Coma; Cytarabine; Female; Humans; Injections, Spinal; Methotrexate; Neoplasm Recurrence, Local; Paralysis; Paraplegia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases

1991
Central nervous system relapse prevention in 1165 standard-risk children with acute lymphoblastic leukemia in five BFM trials.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; Germany, West; Humans; Injections, Spinal; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Spinal Cord Neoplasms

1990
Transient focal leukoencephalopathy following intraventricular methotrexate and cytarabine. A complication of the Ommaya reservoir: case report and review of the literature.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1990, Volume: 6, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Cytarabine; Humans; Infusions, Parenteral; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1990
Therapy for childhood non-Hodgkin's lymphomas, nonlymphoblastic type. Review of recent studies and current recommendations.
    The American journal of pediatric hematology/oncology, 1990,Fall, Volume: 12, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Brain Neoplasms; Cell Differentiation; Child; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Daunorubicin; Doxorubicin; France; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survival Rate; United States; Vincristine

1990
Late anaplastic gliomas in children previously treated for acute lymphoblastic leukemia.
    Pediatric neuroscience, 1989, Volume: 15, Issue:4

    Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Glioma; Humans; Infant; Methotrexate; Neoplasms, Radiation-Induced; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy

1989
Neurotoxicity due to central nervous system therapy for childhood leukemia.
    The American journal of pediatric hematology/oncology, 1989,Spring, Volume: 11, Issue:1

    Topics: Central Nervous System; Child; Cytarabine; Humans; Meningeal Neoplasms; Methotrexate; Neurosecretory Systems; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
[Intensification of the initial treatment in acute lymphoblastic leukemias of middle and high risk in children].
    Anales espanoles de pediatria, 1989, Volume: 30, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Cytarabine; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors

1989
Radiotherapy vs intrathecal chemotherapy for CNS prophylaxis in childhood ALL.
    Oncology (Williston Park, N.Y.), 1989, Volume: 3, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Combined Modality Therapy; Humans; Injections, Spinal; Methotrexate; Nervous System Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989

Trials

328 trial(s) available for methotrexate and Acute Lymphoid Leukemia

ArticleYear
SWOG 1318: A Phase II Trial of Blinatumomab Followed by POMP Maintenance in Older Patients With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2022, 05-10, Volume: 40, Issue:14

    Topics: Aged; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Humans; Lymphoma, B-Cell; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
Hyper-CVAD and sequential blinatumomab for newly diagnosed Philadelphia chromosome-negative B-cell acute lymphocytic leukaemia: a single-arm, single-centre, phase 2 trial.
    The Lancet. Haematology, 2022, Volume: 9, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2022
Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.
    Journal of hematology & oncology, 2023, 05-02, Volume: 16, Issue:1

    Topics: Adult; Antibodies, Bispecific; Cardiovascular Diseases; Humans; Inotuzumab Ozogamicin; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Salvage Therapy

2023
Chemotherapy intravenously in children with cancer at home, the nurse practitioner makes it possible!
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019, Volume: 27, Issue:12

    Topics: Administration, Intravenous; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cytarabine; Female; Home Care Services; Humans; Male; Methotrexate; Netherlands; Nurse Practitioners; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life

2019
Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial.
    Leukemia, 2020, Volume: 34, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Time; Treatment Outcome; Vincristine

2020
Association of
    Pediatric hematology and oncology, 2020, Volume: 37, Issue:3

    Topics: Genotype; Malaysia; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Adolescent and young adult acute lymphoblastic leukemia. Final results of the phase II pediatric-like GIMEMA LAL-1308 trial.
    American journal of hematology, 2021, 03-01, Volume: 96, Issue:3

    Topics: Adolescent; Adult; Allografts; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Italy; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome; Vincristine; Young Adult

2021
Adaptive functioning and academic achievement in survivors of childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:4

    Topics: Academic Success; Adaptation, Psychological; Adolescent; Antineoplastic Agents; Cancer Survivors; Child; Child, Preschool; Dexamethasone; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome

2021
Maintenance therapy and risk of osteonecrosis in children and young adults with acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
    Cancer chemotherapy and pharmacology, 2021, Volume: 88, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; DNA Adducts; Erythrocytes; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Middle Aged; Osteonecrosis; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Thioguanine; Young Adult

2021
Hepatic sinusoidal obstruction syndrome during maintenance therapy of childhood acute lymphoblastic leukemia is associated with continuous asparaginase therapy and mercaptopurine metabolites.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:9

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Drug Interactions; Female; Hepatic Veno-Occlusive Disease; Humans; Infant; Kaplan-Meier Estimate; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models

2017
Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, Dec-20, Volume: 35, Issue:36

    Topics: Adolescent; Adult; Aged; Antilymphocyte Serum; Double-Blind Method; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; HLA Antigens; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Tacrolimus; Young Adult

2017
Effectiveness of antibacterial prophylaxis during induction chemotherapy in children with acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2018, Volume: 65, Issue:5

    Topics: Adolescent; Adult; Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacteremia; Child; Child, Preschool; Doxorubicin; Female; Follow-Up Studies; Humans; Induction Chemotherapy; Infant; Male; Methotrexate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Rate; Vincristine; Young Adult

2018
Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia.
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2018, Volume: 27, Issue:8

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Infant; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2018
High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation.
    Leukemia, 2013, Volume: 27, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Risk Factors; Transplantation, Homologous; Treatment Outcome; Vincristine

2013
Treatment for hepatitis C virus-induced portal hypertension in leukemic children.
    Medical oncology (Northwood, London, England), 2013, Volume: 30, Issue:2

    Topics: Administration, Oral; Amlodipine; Antineoplastic Combined Chemotherapy Protocols; Blood Pressure; Calcium Channel Blockers; Child; Cohort Studies; Heart Rate; Hepatitis C; Humans; Hypertension, Portal; Male; Mercaptopurine; Methotrexate; Portal Pressure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2013
Incorporation of 6-thioguanine nucleotides into DNA during maintenance therapy of childhood acute lymphoblastic leukemia-the influence of thiopurine methyltransferase genotypes.
    Journal of clinical pharmacology, 2013, Volume: 53, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; DNA; Female; Genotype; Guanine Nucleotides; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides

2013
Caregiving demands and well-being in parents of children treated with outpatient or inpatient methotrexate infusion: a report from the children's oncology group.
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:6

    Topics: Adult; Antimetabolites, Antineoplastic; Caregivers; Child; Child, Preschool; Cost of Illness; Female; Health Services Accessibility; Humans; Infusions, Intravenous; Inpatients; Male; Methotrexate; Outpatients; Parents; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Socioeconomic Factors

2014
Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia.
    European journal of clinical pharmacology, 2013, Volume: 69, Issue:9

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Child; Child, Preschool; Enzyme Inhibitors; Female; Humans; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins

2013
[Molecular genetic detection of minimal residual disease (MRD) in children with acute lymphoblastic leukemia].
    Klinische Padiatrie, 2013, Volume: 225 Suppl 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Genetic Markers; Humans; Mercaptopurine; Methotrexate; Neoplasm, Residual; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Vincristine

2013
Prediction of outcome by early response in childhood acute lymphoblastic leukemia.
    Klinische Padiatrie, 2013, Volume: 225 Suppl 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biopsy; Bone Marrow; Cell Lineage; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Patient Outcome Assessment; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Remission Induction; Risk Assessment; Vincristine

2013
Disseminated lymphoblastic lymphoma in children and adolescents: results of the COG A5971 trial: a report from the Children's Oncology Group.
    British journal of haematology, 2013, Volume: 162, Issue:6

    Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Cyclophosphamide; Disease-Free Survival; Female; Humans; Injections, Spinal; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2013
Extended duration of prehydration does not prevent nephrotoxicity or delayed drug elimination in high-dose methotrexate infusions: a prospectively randomized cross-over study.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:2

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Combined Modality Therapy; Cross-Over Studies; Female; Fluid Therapy; Follow-Up Studies; Humans; Infant; Infusions, Intravenous; Kidney Diseases; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Time Factors; Tissue Distribution; Young Adult

2014
The circadian schedule for childhood acute lymphoblastic leukemia maintenance therapy does not influence event-free survival in the NOPHO ALL92 protocol.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:4

    Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Circadian Rhythm; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Survival Rate

2014
The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial.
    Blood, 2014, Mar-27, Volume: 123, Issue:13

    Topics: Adolescent; Child; Child, Preschool; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sirolimus; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous; Whole-Body Irradiation; Young Adult

2014
Dose intensification of methotrexate and cytarabine during intensified continuation chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: POG 9406: a report from the Children's Oncology Group.
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Factors; Survival Rate; Teniposide

2014
Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukaemia (UKALL 2003): a randomised controlled trial.
    The Lancet. Oncology, 2014, Volume: 15, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Consolidation Chemotherapy; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Hypersensitivity; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Mucositis; Neoplasm, Residual; Pancreatitis; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Assessment; Stomatitis; Survival Rate; Vincristine

2014
Safety and clinical activity of 5-aza-2'-deoxycytidine (decitabine) with or without Hyper-CVAD in relapsed/refractory acute lymphocytic leukaemia.
    British journal of haematology, 2014, Volume: 167, Issue:3

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Decitabine; Dexamethasone; DNA Methylation; DNA, Neoplasm; Doxorubicin; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Hyperglycemia; Infusions, Intravenous; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Salvage Therapy; Vincristine; Young Adult

2014
Long-term outcome of a pediatric-inspired regimen used for adults aged 18-50 years with newly diagnosed acute lymphoblastic leukemia.
    Leukemia, 2015, Volume: 29, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Doxorubicin; Drug Administration Schedule; Female; Humans; Karyotyping; Male; Methotrexate; Middle Aged; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Treatment Outcome; Vincristine

2015
Postinduction minimal residual disease monitoring by polymerase chain reaction in children with acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Nov-01, Volume: 32, Issue:31

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Italy; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; Remission Induction; Steroids; Treatment Outcome

2014
Phase II study of methotrexate, vincristine, pegylated-asparaginase, and dexamethasone (MOpAD) in patients with relapsed/refractory acute lymphoblastic leukemia.
    American journal of hematology, 2015, Volume: 90, Issue:2

    Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Bilirubin; Dexamethasone; Female; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Recurrence; Rituximab; Survival Analysis; T-Lymphocytes; Transaminases; Treatment Outcome; Vincristine

2015
Long-term results of the AIEOP LNH-97 protocol for childhood lymphoblastic lymphoma.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:8

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers, Tumor; Child; Cyclophosphamide; Disease Progression; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2015
Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study.
    The Lancet. Oncology, 2015, Volume: 16, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Risk Factors; United States; Vincristine

2015
Therapeutic value of black seed oil in methotrexate hepatotoxicity in Egyptian children with acute lymphoblastic leukemia.
    Infectious disorders drug targets, 2015, Volume: 15, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cuminum; Female; Humans; Infant; Leucovorin; Liver; Male; Methotrexate; Plant Oils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Seeds

2015
Long-term follow-up of imatinib plus combination chemotherapy in patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia.
    American journal of hematology, 2015, Volume: 90, Issue:11

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Survival Analysis; Transplantation, Homologous; Vincristine

2015
Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
    Cancer, 2015, Dec-01, Volume: 121, Issue:23

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm, Residual; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Treatment Outcome; Vincristine; Young Adult

2015
ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: A randomized placebo-controlled study.
    Nutrition (Burbank, Los Angeles County, Calif.), 2016, Volume: 32, Issue:1

    Topics: Adolescent; Antioxidants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Double-Blind Method; Fatty Acids, Omega-3; Female; Glutathione Peroxidase; Humans; Liver; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Superoxide Dismutase

2016
Efficacy and toxicity of a paediatric protocol in teenagers and young adults with Philadelphia chromosome negative acute lymphoblastic leukaemia: results from UKALL 2003.
    British journal of haematology, 2016, Volume: 172, Issue:3

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Daunorubicin; Dexamethasone; Female; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Assessment; Survival Analysis; Treatment Outcome; Vincristine; Young Adult

2016
Anxiety, pain, and nausea during the treatment of standard-risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group.
    Cancer, 2016, Apr-01, Volume: 122, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Anxiety; Asparaginase; Child; Child, Preschool; Consolidation Chemotherapy; Cyclophosphamide; Cytarabine; Dexamethasone; Female; Humans; Induction Chemotherapy; Longitudinal Studies; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Nausea; Pain; Parents; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Surveys and Questionnaires; Vincristine

2016
Dexamethasone vs prednisone in induction treatment of pediatric ALL: results of the randomized trial AIEOP-BFM ALL 2000.
    Blood, 2016, 04-28, Volume: 127, Issue:17

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Dexamethasone; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Kaplan-Meier Estimate; Male; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Remission Induction; Treatment Outcome

2016
Influence of Folate-Related Gene Polymorphisms on High-Dose Methotrexate-Related Toxicity and Prognosis in Turkish Children with Acute Lymphoblastic Leukemia.
    Turkish journal of haematology : official journal of Turkish Society of Haematology, 2017, Jun-05, Volume: 34, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Disease-Free Survival; Female; Ferredoxin-NADP Reductase; Humans; Infant; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate

2017
Mexican Childhood Acute Lymphoblastic Leukemia: A Pilot Study of the MDR1 and MTHFR Gene Polymorphisms and Their Associations with Clinical Outcomes.
    Genetic testing and molecular biomarkers, 2016, Volume: 20, Issue:10

    Topics: Adolescent; ATP Binding Cassette Transporter, Subfamily B; Child; Child, Preschool; Female; Homozygote; Humans; Leukopenia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Mucositis; Pilot Projects; Polymorphism, Restriction Fragment Length; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

2016
High hyperdiploid acute lymphoblastic leukemia (ALL)-A 25-year population-based survey of the Austrian ALL-BFM (Berlin-Frankfurt-Münster) Study Group.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chromosomes, Human, Pair 17; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Male; Mercaptopurine; Methotrexate; Mosaicism; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Time Factors; Trisomy; Vincristine

2017
A thymidylate synthase polymorphism is associated with increased risk for bone toxicity among children treated for acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:7

    Topics: Adolescent; Antimetabolites, Antineoplastic; Asparaginase; Child; Child, Preschool; Female; Fractures, Bone; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Osteonecrosis; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase

2017
Neurocognitive outcomes among children who experienced seizures during treatment for acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cognition Disorders; Cytarabine; Dexamethasone; Female; Humans; Hydrocortisone; Incidence; Leukoencephalopathies; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Seizures; Vincristine

2017
Minimal residual disease is an important predictive factor of outcome in children with relapsed 'high-risk' acute lymphoblastic leukemia.
    Leukemia, 2008, Volume: 22, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Prognosis; Prospective Studies; Recurrence; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Survival Analysis; Treatment Outcome; Vincristine

2008
Intensive chemotherapy improved treatment outcome for Chinese children and adolescents with lymphoblastic lymphoma.
    International journal of clinical oncology, 2008, Volume: 13, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Humans; Injections, Spinal; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2008
Relationship between oral mucositis and high-dose methotrexate therapy in pediatric acute lymphoblastic leukemia.
    International journal of clinical pharmacology and therapeutics, 2008, Volume: 46, Issue:11

    Topics: Adolescent; Antimetabolites, Antineoplastic; Area Under Curve; Cell Survival; Cells, Cultured; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infant; Keratinocytes; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis

2008
[Investigation on individualized adjustment of target range of high-dose methotrexate].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2008, Volume: 46, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2008
Pharmacokinetics of high-dose methotrexate in infants treated for acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2009, Volume: 52, Issue:5

    Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2009
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
    The New England journal of medicine, 2009, Jun-25, Volume: 360, Issue:26

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Daunorubicin; Dexamethasone; Hematopoietic Stem Cell Transplantation; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Secondary Prevention; Survival Analysis; Treatment Outcome; Vincristine

2009
DV-ICE, intensive induction and early transplantation for adult patients with acute lymphoblastic leukemia: a phase II study.
    European journal of haematology, 2009, Dec-01, Volume: 83, Issue:6

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cytarabine; Dexamethasone; Disease-Free Survival; Early Termination of Clinical Trials; Etoposide; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Hydrocortisone; Idarubicin; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Treatment Failure; Vincristine; Young Adult

2009
Response to glucocorticoids and toxicity in childhood acute lymphoblastic leukemia: role of polymorphisms of genes involved in glucocorticoid response.
    Pediatric blood & cancer, 2009, Volume: 53, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Dexamethasone; Female; Glucocorticoids; Glutathione Transferase; Humans; Infant; Infections; Male; Methotrexate; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone

2009
Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:6

    Topics: Administration, Oral; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Survival Analysis; Treatment Outcome; Vincristine

2009
A phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft versus host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL).
    British journal of haematology, 2009, Volume: 147, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Epidemiologic Methods; Female; Graft Survival; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Sirolimus; Tacrolimus; Treatment Outcome; Young Adult

2009
Comparison of neurocognitive functioning in children previously randomly assigned to intrathecal methotrexate compared with triple intrathecal therapy for the treatment of childhood acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Dec-10, Volume: 27, Issue:35

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Attention; Child; Child, Preschool; Cognition; Cross-Sectional Studies; Cytarabine; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Intelligence Tests; Linear Models; Male; Memory; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Time Factors; Treatment Outcome; United States

2009
Population pharmacokinetic study of methotrexate in children with acute lymphoblastic leukemia.
    International journal of clinical pharmacology and therapeutics, 2010, Volume: 48, Issue:1

    Topics: Age Factors; Antimetabolites, Antineoplastic; Asian People; Bayes Theorem; Body Surface Area; Child; Child, Preschool; China; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Methotrexate; Models, Biological; Nonlinear Dynamics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors; Tissue Distribution

2010
Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial.
    Blood, 2010, Apr-08, Volume: 115, Issue:14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Hepatic Veno-Occlusive Disease; Humans; Hypertension, Portal; Infant; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine

2010
Benefits of the intermittent use of 6-mercaptopurine and methotrexate in maintenance treatment for low-risk acute lymphoblastic leukemia in children: randomized trial from the Brazilian Childhood Cooperative Group--protocol ALL-99.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Apr-10, Volume: 28, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brazil; Child; Child, Preschool; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors; Survival Rate; Treatment Outcome

2010
The association of reduced folate carrier 80G>A polymorphism to outcome in childhood acute lymphoblastic leukemia interacts with chromosome 21 copy number.
    Blood, 2010, Jun-10, Volume: 115, Issue:23

    Topics: Adolescent; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Child; Child, Preschool; Chromosomes, Human, Pair 21; Female; Humans; Infant; Male; Membrane Transport Proteins; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Remission Induction; Retrospective Studies

2010
Simultaneous detection of MDR1 and WT1 gene expression to predict the prognosis of adult acute lymphoblastic leukemia.
    Hematology (Amsterdam, Netherlands), 2010, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor; Bone Marrow; Cohort Studies; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Leukemic; Genes, Wilms Tumor; Humans; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; RNA, Messenger; RNA, Neoplasm; Vincristine; WT1 Proteins; Young Adult

2010
Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2010, Volume: 55, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Dexamethasone; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Assessment; Survival Analysis; Treatment Outcome; Vincristine

2010
Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial.
    Lancet (London, England), 2010, Dec-11, Volume: 376, Issue:9757

    Topics: Adolescent; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Etoposide; Female; Humans; Idarubicin; Infant; Kaplan-Meier Estimate; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk Assessment; Treatment Outcome; United Kingdom; Vidarabine; Vincristine

2010
Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.
    PLoS computational biology, 2010, Dec-02, Volume: 6, Issue:12

    Topics: Cell Division; Cohort Studies; Computational Biology; Computer Simulation; Drug Resistance, Neoplasm; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Polyglutamic Acid; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2010
The utility of performing the initial lumbar puncture on day 8 in remission induction therapy for childhood acute lymphoblastic leukemia: TCCSG L99-15 study.
    Pediatric blood & cancer, 2012, Volume: 58, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Cytarabine; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Neoplasm Recurrence, Local; Netherlands; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prospective Studies; Remission Induction; Spinal Puncture; Survival Rate; Time Factors; Treatment Outcome

2012
[Long-term observations of children with acute lymphoblastic leukemia and high leukocytosis treated according to modified "New York" protocols (1987-2003)].
    Przeglad lekarski, 2010, Volume: 67, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Comorbidity; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Leukocytosis; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Thioguanine; Vincristine

2010
[Clinical tolerance of high-dose methotrexate used in consolidation therapy in children with acute lymphoblastic leukemia].
    Przeglad lekarski, 2010, Volume: 67, Issue:6

    Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Incidence; Infant; Infections; Male; Methotrexate; Nausea; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vomiting

2010
Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: results of Children's Oncology Group trial P9906.
    Pediatric blood & cancer, 2011, Volume: 57, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Thioguanine; Treatment Outcome; Vincristine

2011
Fludarabine and pharmacokinetic-targeted busulfan before allografting for adults with acute lymphoid leukemia.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2011, Volume: 17, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Disease-Free Survival; Female; Follow-Up Studies; Graft Survival; Graft vs Host Disease; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous; Vidarabine

2011
The role of HLA--G 14-bp polymorphism in allo-HSCT after short-term course MTX for GvHD prophylaxis.
    Bone marrow transplantation, 2012, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Child; Disease-Free Survival; Female; Follow-Up Studies; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; HLA-G Antigens; Humans; Immunosuppressive Agents; INDEL Mutation; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate; Time Factors; Transplantation, Homologous

2012
High dose methotrexate treatment in children with acute lymphoblastic leukaemia may be optimised by a weight-based dose calculation.
    Pediatric blood & cancer, 2011, Jul-15, Volume: 57, Issue:1

    Topics: Age Factors; Antimetabolites, Antineoplastic; Body Weight; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Models, Biological; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors

2011
Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, May-01, Volume: 29, Issue:13

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child, Preschool; Drug Administration Schedule; Humans; Infant; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines

2011
Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404).
    Blood, 2011, Jul-28, Volume: 118, Issue:4

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Mucositis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Young Adult

2011
Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group.
    Blood, 2011, Jul-14, Volume: 118, Issue:2

    Topics: Algorithms; Antineoplastic Agents; Child; Child, Preschool; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Infant; Injections, Intravenous; Male; Medical Oncology; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Societies, Medical

2011
Study of the pharmacokinetic and pharmacogenetic contribution to the toxicity of high-dose methotrexate in children with acute lymphoblastic leukemia.
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:3

    Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study.
    British journal of haematology, 2011, Volume: 155, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Feasibility Studies; Female; Fever; Humans; Infant; Male; Mercaptopurine; Methotrexate; Mucositis; Pancreatitis; Pilot Projects; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
Pneumocystis jiroveci pneumonia prophylaxis during maintenance therapy influences methotrexate/6-mercaptopurine dosing but not event-free survival for childhood acute lymphoblastic leukemia.
    European journal of haematology, 2012, Volume: 88, Issue:1

    Topics: Administration, Oral; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Male; Mercaptopurine; Methotrexate; Pneumocystis carinii; Pneumonia, Pneumocystis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Trimethoprim, Sulfamethoxazole Drug Combination

2012
[Efficacy, side effects and blood concentration monitoring of high-dose methotrexate in treatment of 180 children with acute lymphoblastic leukemia].
    Zhongguo shi yan xue ye xue za zhi, 2011, Volume: 19, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
Proinflammatory cytokines during the initial phase of oral mucositis in patients with acute lymphoblastic leukaemia.
    International journal of paediatric dentistry, 2012, Volume: 22, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cytokines; Humans; Inflammation Mediators; Interleukin-1; Interleukin-6; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Stomatitis; Time Factors; Tumor Necrosis Factor-alpha; Young Adult

2012
The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI.
    Journal of hematology & oncology, 2011, Oct-13, Volume: 4

    Topics: Antineoplastic Agents; Central Nervous System Neoplasms; Child, Preschool; Female; Humans; Infant; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
Palonosetron for the prevention of nausea and vomiting in children with acute lymphoblastic leukemia treated with high dose methotrexate.
    Pediatric blood & cancer, 2012, Volume: 59, Issue:5

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Denmark; Female; Humans; Isoquinolines; Male; Methotrexate; Nausea; Palonosetron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinuclidines; Serotonin Antagonists; Time Factors; Vomiting

2012
Asparaginase-associated myelosuppression and effects on dosing of other chemotherapeutic agents in childhood acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2012, Volume: 59, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Female; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Dose intensification of daunorubicin and cytarabine during treatment of adult acute lymphoblastic leukemia: results of Cancer and Leukemia Group B Study 19802.
    Cancer, 2013, Jan-01, Volume: 119, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Young Adult

2013
Treatment of young patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia using increased dose of imatinib and deintensified chemotherapy before allogeneic stem cell transplantation.
    British journal of haematology, 2012, Volume: 159, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Combined Modality Therapy; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Etoposide; Female; Humans; Imatinib Mesylate; Male; Mercaptopurine; Methotrexate; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pyrimidines; Stem Cell Transplantation; Transplantation, Homologous; Treatment Outcome; Vincristine; Young Adult

2012
Effect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:9

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cohort Studies; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Incidence; Infant; Male; Methotrexate; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Sex Distribution; Sex Factors; Survival Rate; Treatment Outcome; Vincristine; Young Adult

2012
Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia.
    Journal of the National Cancer Institute, 2012, Sep-19, Volume: 104, Issue:18

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Attention; Child; Child, Preschool; Cognition; Cranial Irradiation; Cytarabine; Dexamethasone; Drug Administration Schedule; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Intelligence; Intelligence Tests; Logistic Models; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Patient Selection; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Sex Factors; Time Factors; Treatment Outcome; Vincristine

2012
Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemia.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Homocysteine; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Comparison of pharmacokinetics and toxicity after high-dose methotrexate treatments in children with acute lymphoblastic leukemia.
    Anti-cancer drugs, 2013, Volume: 24, Issue:2

    Topics: Adolescent; Antimetabolites, Antineoplastic; Area Under Curve; Cerebrospinal Fluid; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Infant; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2013
Genome-wide study of methotrexate clearance replicates SLCO1B1.
    Blood, 2013, Feb-07, Volume: 121, Issue:6

    Topics: Adolescent; Alleles; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; Infant; Infusions, Intravenous; Leucovorin; Linear Models; Liver-Specific Organic Anion Transporter 1; Male; Metabolic Clearance Rate; Methotrexate; Multivariate Analysis; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2013
Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial.
    The Lancet. Oncology, 2013, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Disease-Free Survival; Female; Humans; Infant; Ireland; Male; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk Factors; Treatment Outcome; United Kingdom; Vincristine

2013
De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo.
    Blood, 2002, Aug-15, Volume: 100, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Leukemia-Lymphoma, Adult T-Cell; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines

2002
Central nervous system prophylaxis with high-dose methotrexate does not give rise to significant electroencephalographic changes in children with acute lymphoblastic leukemia.
    Journal of child neurology, 2002, Volume: 17, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain; Central Nervous System Neoplasms; Child; Child, Preschool; Electroencephalography; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2002
A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:5

    Topics: Aneuploidy; Antimetabolites, Antineoplastic; B-Lymphocytes; Bone Marrow; Burkitt Lymphoma; Carrier Proteins; Cell Lineage; Child; Female; gamma-Glutamyl Hydrolase; Humans; Infusions, Intravenous; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Models, Biological; Neoplasm Proteins; Neoplastic Stem Cells; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; T-Lymphocytes

2002
Treatment outcome of adolescents with acute lymphoblastic leukemia.
    Annals of hematology, 2002, Volume: 81, Issue:11

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Risk Factors; Survival Analysis; Survival Rate; Treatment Outcome

2002
[Results of the treatment of childhood acute lymphoblastic leukemia according to the Berlin-Moscow-91 protocol in 1991-2000].
    Voprosy onkologii, 2002, Volume: 48, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Data Interpretation, Statistical; Daunorubicin; Dexamethasone; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Moscow; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Russia; Survival Analysis; Time Factors; Vincristine

2002
[Treatment of acute lymphoblastic leukemia in children according to the ALL-BFM-90m protocol in the Russian Federation and the Republic of Belarus].
    Voprosy onkologii, 2002, Volume: 48, Issue:3

    Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chi-Square Distribution; Child; Child, Preschool; Data Interpretation, Statistical; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Republic of Belarus; Risk Factors; Russia; Sex Factors; Survival Analysis; Time Factors

2002
Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia: significance of low leukocyte counts with blasts or traumatic lumbar puncture.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jan-15, Volume: 21, Issue:2

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cerebrospinal Fluid; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Female; Humans; Infant; Infant, Newborn; Injections, Spinal; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Risk Factors; Spinal Puncture; Treatment Outcome

2003
Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group.
    Blood, 2003, May-15, Volume: 101, Issue:10

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Blood Cell Count; Child; Child, Preschool; Dexamethasone; Drug Administration Schedule; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Karyotyping; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone

2003
Effects of sodium in hydration solution on plasma methotrexate concentrations following high-dose methotrexate in children with acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2003, Volume: 51, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Female; Fluid Therapy; Humans; Infusions, Intravenous; Liver; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sodium

2003
Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Apr-01, Volume: 21, Issue:7

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Female; Humans; Infant; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Sex Factors; Thioguanine

2003
The dose related effect of steroids on blast reduction rate and event free survival in children with acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2003, Volume: 44, Issue:3

    Topics: Adolescent; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Male; Methotrexate; Methylprednisolone; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Retrospective Studies; Survival Analysis; Treatment Outcome; Vincristine

2003
Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.
    Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:6

    Topics: Antimetabolites, Antineoplastic; Bone Marrow Cells; Child; Chromatography, High Pressure Liquid; Humans; Hypoxanthine; Injections, Intravenous; Leukocyte Count; Mercaptopurine; Methotrexate; Nucleosides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine; Xanthines

2003
Long-term survival in acute lymphoblastic leukaemia in adults treated according to the LALA 87 protocol.
    Chemotherapy, 2003, Volume: 49, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Daunorubicin; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Treatment Outcome; Vincristine

2003
[The assessment of plasma levels of insulin-like growth factor (IGF-I) and binding protein (IGFBP-3) during the maintenance therapy and after remissionof acute lymphoblastic leukemia (ALL)].
    Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych, 2003, Volume: 9, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Height; Body Mass Index; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Puberty; Radiotherapy, Adjuvant; Remission Induction; Vincristine

2003
[Improved results in children with acute lymphoblastic leukemia treated with the ALL-BFM 90 protocol in the Czech Republic].
    Casopis lekaru ceskych, 2003, Volume: 142, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Vincristine

2003
A randomized trial of induction therapy (daunorubicin, vincristine, prednisone versus daunorubicin, vincristine, prednisone, cytarabine and 6-thioguanine) in adult acute lymphoblastic leukemia with long-term follow-up: an Eastern Cooperative Oncology Grou
    Leukemia & lymphoma, 2003, Volume: 44, Issue:9

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Life Tables; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Remission Induction; Survival Analysis; Thioguanine; Treatment Outcome; Vincristine

2003
Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172).
    British journal of haematology, 2004, Volume: 124, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Humans; Infant; Leukocyte Count; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2004
Does vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2004, Volume: 12, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Lymphoma, Non-Hodgkin; Malabsorption Syndromes; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Protective Agents; Retinol-Binding Proteins; Vitamin A; Xylose

2004
Correlation of cerebrospinal fluid beta-glucuronidase activity with plasma methotrexate concentrations in leukemic children receiving high-dose methotrexate.
    Pediatric blood & cancer, 2004, Volume: 42, Issue:4

    Topics: Biomarkers; Child; Child, Preschool; Clinical Enzyme Tests; Female; Glucuronidase; Humans; Infant; Inflammation; Linear Models; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2004
Skeletal morbidity in childhood acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Apr-01, Volume: 22, Issue:7

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Bone Density; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Female; Follow-Up Studies; Fractures, Bone; Humans; Infant; Lumbar Vertebrae; Male; Methotrexate; Morbidity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors

2004
High-dose methotrexate therapy of childhood acute lymphoblastic leukemia: lack of relation between serum methotrexate concentration and creatinine clearance.
    Pediatric blood & cancer, 2004, Volume: 43, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Chile; Creatine; Disease-Free Survival; Drug Monitoring; Female; Hematologic Diseases; Humans; Infant; Leucovorin; Male; Metabolic Clearance Rate; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis

2004
[Effects of different first dose calcium tetrahydro-folate on toxicity and side effects of large dose methotrexate treated standard risk group children with acute lymphoblastic leukemia].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2004, Volume: 42, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors; Tetrahydrofolates; Treatment Outcome

2004
Toxicity and efficacy of intensive chemotherapy for children with acute lymphoblastic leukemia (ALL) after first bone marrow or extramedullary relapse.
    Pediatric blood & cancer, 2004, Volume: 43, Issue:5

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacteremia; Bone Marrow Neoplasms; Child; Child, Preschool; Cytarabine; Dexamethasone; Etoposide; Female; Flow Cytometry; Humans; Idarubicin; Ifosfamide; Infant; Infusions, Intravenous; Leucovorin; Male; Mesna; Methotrexate; Mouth Mucosa; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Stomatitis; Thioguanine; Treatment Outcome; Vincristine

2004
Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
    Leukemia, 2005, Volume: 19, Issue:4

    Topics: Antimetabolites, Antineoplastic; B-Lymphocytes; Child; Child, Preschool; Female; Follow-Up Studies; Hematopoietic Stem Cells; Humans; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Treatment Outcome

2005
Value of intravenous 6-mercaptopurine during continuation treatment in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma: final results of a randomized phase III trial (58881) of the EORTC CLG.
    Leukemia, 2005, Volume: 19, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Evaluation Studies as Topic; Female; Humans; Infant; Injections, Intravenous; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Patient Compliance; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Treatment Outcome

2005
The effects of ondansetron and granisetron on electrocardiography in children receiving chemotherapy for acute leukemia.
    American journal of clinical oncology, 2005, Volume: 28, Issue:2

    Topics: Adolescent; Antiemetics; Antimetabolites, Antineoplastic; Child; Child, Preschool; Electrocardiography; Female; Granisetron; Heart Rate; Humans; Male; Methotrexate; Nausea; Ondansetron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serotonin Antagonists; Vomiting

2005
Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only.
    Pediatric blood & cancer, 2005, Volume: 44, Issue:5

    Topics: Antineoplastic Agents; Attention; Central Nervous System Neoplasms; Child; Cognition Disorders; Contraindications; Female; Humans; Injections, Spinal; Male; Mental Processes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychological Tests; Radiotherapy; Survivors

2005
Capacity buffer of the saliva in children and adolescents with cancer: Variations induced by the administration of metotrexate or cyclophosphamide.
    Medicina oral, patologia oral y cirugia bucal, 2005, 07-01, Volume: 10 Suppl2

    Topics: Acid-Base Equilibrium; Adolescent; Antineoplastic Agents, Alkylating; Buffers; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Hydrogen-Ion Concentration; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva

2005
Transplant-finalized salvage of adult acute lymphoblastic leukemia: results of a mitoxantrone- and methotrexate-based regimen in 36 patients.
    Leukemia & lymphoma, 2005, Volume: 46, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Treatment Outcome; Vincristine

2005
Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Nov-01, Volume: 23, Issue:31

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Factors; Salvage Therapy; Survival Rate; Thioguanine; Time Factors; Treatment Outcome

2005
Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2005, Volume: 16, Issue:12

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Hydrocortisone; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Survival Rate; Vincristine

2005
MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95.
    Annals of hematology, 2006, Volume: 85, Issue:5

    Topics: Adolescent; Age Factors; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Homozygote; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Sex Factors; Treatment Outcome

2006
Population pharmacokinetic study of methotrexate in patients with lymphoid malignancy.
    Cancer chemotherapy and pharmacology, 2006, Volume: 58, Issue:5

    Topics: Adult; Age Factors; Aged; Algorithms; Antimetabolites, Antineoplastic; Bayes Theorem; Burkitt Lymphoma; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Lymphoma, Large B-Cell, Diffuse; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

2006
Role of treatment intensification in infants with acute lymphoblastic leukemia: results of two consecutive AIEOP studies.
    Haematologica, 2006, Volume: 91, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Hematopoietic Stem Cell Transplantation; Humans; Infant, Newborn; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine

2006
Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993.
    Blood, 2006, Jul-15, Volume: 108, Issue:2

    Topics: Adolescent; Adult; Asparaginase; Central Nervous System Neoplasms; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate

2006
Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemi
    Blood, 2006, Aug-15, Volume: 108, Issue:4

    Topics: Age Factors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Female; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Retrospective Studies; Risk Factors; Sex Factors; T-Lymphocytes; Testicular Neoplasms; Time Factors

2006
Brief report: effect of intravenous methotrexate dose and infusion rate on neuropsychological function one year after diagnosis of acute lymphoblastic leukemia.
    Journal of pediatric psychology, 2007, Volume: 32, Issue:2

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Longitudinal Studies; Male; Memory Disorders; Memory, Short-Term; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Verbal Learning; Vocabulary; Wechsler Scales

2007
[Assessment of elimination and tolerance of high dose of methotrexate (3 g/m2) in children with standard-risk acute lymphoblastic leukemia].
    Przeglad lekarski, 2006, Volume: 63, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Infant; Kidney; Liver; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2006
Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia.
    Blood, 2006, Dec-15, Volume: 108, Issue:13

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Remission Induction; Retrospective Studies; Teniposide

2006
Results of the PETHEMA ALL-96 trial in elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia.
    European journal of haematology, 2007, Volume: 78, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Comorbidity; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Middle Aged; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Severity of Illness Index; Survival Analysis; Teniposide; Treatment Outcome; Vincristine

2007
Population pharmacokinetics of high-dose methotrexate in children with acute lymphoblastic leukaemia.
    Clinical pharmacokinetics, 2006, Volume: 45, Issue:12

    Topics: Adolescent; Age Factors; Alanine Transaminase; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Bayes Theorem; Body Weight; Child; Child, Preschool; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Infant; Infusions, Intravenous; Leucovorin; Male; Metabolic Clearance Rate; Methotrexate; Models, Biological; Monte Carlo Method; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Vitamin B Complex

2006
High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations.
    Clinical pharmacology and therapeutics, 2006, Volume: 80, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Area Under Curve; Child; Dose-Response Relationship, Drug; Female; Gene Frequency; Germany; Half-Life; Haplotypes; Humans; Infusions, Intravenous; Male; Membrane Transport Proteins; Metabolic Clearance Rate; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Multivariate Analysis; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Sex Factors

2006
Methotrexate pharmacokinetics in infants with acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2007, Volume: 59, Issue:6

    Topics: Age Factors; Drug Administration Schedule; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Very high-dose methotrexate (33.6 g/m(2)) as central nervous system preventive therapy for childhood acute lymphoblastic leukemia: results of National Cancer Institute/Children's Cancer Group trials CCG-191P, CCG-134P and CCG-144P.
    Leukemia & lymphoma, 2006, Volume: 47, Issue:12

    Topics: Adolescent; Adult; Central Nervous System Neoplasms; Child; Child, Preschool; Cognition; Female; Humans; Infant; Male; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Treatment Outcome

2006
Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.
    Leukemia, 2007, Volume: 21, Issue:2

    Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Brain Diseases, Metabolic; Child; Child, Preschool; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Neurotoxins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Assessment

2007
Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia.
    Blood, 2007, Apr-15, Volume: 109, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Encephalitis; Female; Humans; Injections, Spinal; Leukemic Infiltration; Liposomes; Male; Meninges; Meningitis; Methotrexate; Middle Aged; Papilledema; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Vincristine

2007
Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial.
    Lancet (London, England), 2007, Jan-13, Volume: 369, Issue:9556

    Topics: Adolescent; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dexamethasone; Disease-Free Survival; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2007
Intravenous busulfan and melphalan, tacrolimus, and short-course methotrexate followed by unmodified HLA-matched related or unrelated hematopoietic stem cell transplantation for the treatment of advanced hematologic malignancies.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2007, Volume: 13, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; Child, Preschool; Female; Hematopoietic Stem Cell Transplantation; Histocompatibility Testing; Humans; Immunosuppressive Agents; Infant; Leukemia, Myeloid, Acute; Male; Melphalan; Methotrexate; Middle Aged; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Survival Analysis; Tacrolimus; Transplantation Conditioning

2007
[Auditory evoked potentials in patients after acute children's lymphoblastic leukemia treatment].
    Przeglad lekarski, 2006, Volume: 63, Issue:11

    Topics: Acoustic Stimulation; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Evoked Potentials, Auditory, Brain Stem; Female; Hearing Disorders; Hearing Tests; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Reaction Time; Thioguanine; Vincristine

2006
[Peripheral blood stem cell transplantation for 53 patients with malignant hematologic diseases].
    Ai zheng = Aizheng = Chinese journal of cancer, 2007, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclosporine; Disease-Free Survival; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation Conditioning; Transplantation, Homologous; Young Adult

2007
Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201.
    Blood, 2007, Aug-15, Volume: 110, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Cell Lineage; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Infusions, Intravenous; Injections, Intramuscular; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine

2007
[Modified BFM-90 regimen greatly improves treatment outcomes of chinese childhood and adolescent lymphoblastic lymphoma].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2007, Volume: 29, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asian People; Asparaginase; Child; Child, Preschool; China; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine

2007
Evaluation of renal function in Turkish children receiving BFM-95 therapy for acute lymphoblastic leukemia.
    Pediatric hematology and oncology, 2007, Volume: 24, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Kidney Diseases; Kidney Function Tests; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Turkey; Vincristine

2007
Phase II study of chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia or lymphoblastic lymphoma: Japan Clinical Oncology Group Study 9004.
    Cancer science, 2007, Volume: 98, Issue:9

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Combined Modality Therapy; Cytarabine; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stem Cell Transplantation; Transplantation, Autologous

2007
A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.
    Lancet (London, England), 2007, Jul-21, Volume: 370, Issue:9583

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Follow-Up Studies; Humans; Infant; Infant, Newborn; Leukemia, Myeloid, Acute; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone

2007
Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:1

    Topics: Adolescent; Aminopterin; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Diseases; Child; Child, Preschool; Drug Overdose; Erythrocytes; Female; Fever; Folic Acid Antagonists; Gastrointestinal Diseases; Humans; Leucovorin; Male; Methotrexate; Neurotoxicity Syndromes; Pilot Projects; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome

2008
[The results of a multicenter trial of acute lymphoblastic leukemia treatment on ALL-MB 91/ALL-BFM 90m in children: analysis of efficacy and toxicity].
    Terapevticheskii arkhiv, 2007, Volume: 79, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome; Vincristine

2007
Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Nov-01, Volume: 25, Issue:31

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Central Nervous System Neoplasms; Child; Child, Preschool; Cranial Irradiation; Cytarabine; Female; Glucocorticoids; Humans; Hydrocortisone; Infant; Injections, Spinal; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia.
    Blood, 2008, Mar-01, Volume: 111, Issue:5

    Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2008
Outcome after relapse among children with standard-risk acute lymphoblastic leukemia: Children's Oncology Group study CCG-1952.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Dec-20, Volume: 25, Issue:36

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Female; Humans; Hydrocortisone; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Stem Cell Transplantation; Survival Analysis; Thioguanine; Treatment Outcome

2007
Long-term results of the AIEOP-ALL-95 Trial for Childhood Acute Lymphoblastic Leukemia: insight on the prognostic value of DNA index in the framework of Berlin-Frankfurt-Muenster based chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Jan-10, Volume: 26, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chi-Square Distribution; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; DNA, Neoplasm; Female; Humans; Infant; Italy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Survival Rate; Treatment Outcome; Vincristine

2008
Results of the first randomized multicentre trial on childhood acute lymphoblastic leukaemia in Russia.
    Leukemia, 2008, Volume: 22, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Feasibility Studies; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Palliative Care; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Russia; Treatment Outcome; Vincristine

2008
Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the Programa Español de Tratamiento en Hematología pediatric-based protocol ALL-96.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Apr-10, Volume: 26, Issue:11

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Hematologic Diseases; Humans; Hydrocortisone; Infant; Infections; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Treatment Outcome; Vincristine

2008
Aggressive lymphomas with renal involvement: a study of 48 patients treated with the LNH-84 and LNH-87 regimens. Groupe d'Etude des Lymphomes de l'Adulte.
    British journal of cancer, 1994, Volume: 70, Issue:1

    Topics: Actuarial Analysis; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chi-Square Distribution; Creatinine; Cyclophosphamide; Doxorubicin; Female; Humans; Kidney; Kidney Neoplasms; L-Lactate Dehydrogenase; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, Non-Hodgkin; Male; Methotrexate; Methylprednisolone; Middle Aged; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Proportional Hazards Models; Remission Induction; Survival Analysis; Survival Rate; Treatment Outcome; Vindesine

1994
Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia.
    Blood, 1994, Jul-15, Volume: 84, Issue:2

    Topics: Burkitt Lymphoma; Child; Hematopoietic Stem Cells; Humans; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Peptide Synthases; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1994
Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.
    The Journal of clinical investigation, 1994, Volume: 94, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Ploidies; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1994
Changes of cerebral biopterin and biogenic amine metabolism in leukemic children receiving 5 g/m2 intravenous methotrexate.
    Pediatric research, 1995, Volume: 37, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biogenic Amines; Biopterins; Brain Chemistry; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytarabine; Dihydropteridine Reductase; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Nerve Tissue Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

1995
Concomitant granulocyte colony-stimulating factor and induction chemoradiotherapy in adult acute lymphoblastic leukemia: a randomized phase III trial.
    Blood, 1995, Jul-15, Volume: 86, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Disease-Free Survival; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Immunologic Factors; Infection Control; Male; Mercaptopurine; Methotrexate; Middle Aged; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Recombinant Proteins; Remission Induction; Survival Analysis; Treatment Outcome

1995
Short-term weekly chemotherapy followed by high-dose therapy with autologous bone marrow transplantation for lymphoblastic and Burkitt's lymphomas in adult patients.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1995, Volume: 6, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Burkitt Lymphoma; Carmustine; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Transplantation, Autologous; Vincristine

1995
L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins.
    Leukemia, 1995, Volume: 9, Issue:10

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Synergism; Etoposide; Humans; Infant; Karyotyping; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone

1995
Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster-based intensive chemotherapy. The Associazione Italiana d
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:10

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Regression Analysis; Remission Induction; Survival Analysis; Vincristine

1995
Cognitive sequelae of treatment in childhood acute lymphoblastic leukemia: cranial radiation requires an accomplice.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:10

    Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Humans; Injections, Intravenous; Injections, Spinal; Intelligence; Intelligence Tests; Male; Memory Disorders; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Sex Factors

1995
Outcome of treatment in adult acute lymphoblastic leukaemia in an Asian population: comparison with previous multicentre German study.
    Leukemia, 1995, Volume: 9, Issue:6

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asia; Asparaginase; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Ethnicity; Female; Follow-Up Studies; Germany; Humans; Malaysia; Male; Methotrexate; Methylprednisolone; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Probability; Racial Groups; Survival Rate; Time Factors; Treatment Outcome; Vincristine

1995
[Extramedullary relapse in childhood acute lymphoblastic leukemia: experience at the Kyushu Yamaguchi Children's Cancer Study Group].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1995, Volume: 36, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Cytarabine; Female; Humans; Infant; Male; Methotrexate; Ovarian Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Testicular Neoplasms

1995
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
    Blood, 1995, Apr-15, Volume: 85, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Administration Schedule; Female; Humans; Immunophenotyping; Life Tables; Male; Mercaptopurine; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Risk Factors; Survival Analysis; Thioguanine; Treatment Outcome; Vincristine

1995
Repetitive low dose oral methotrexate and intravenous mercaptopurine treatment for patients with lower risk B-lineage acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study.
    Cancer, 1995, May-15, Volume: 75, Issue:10

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Central Nervous System Neoplasms; Child; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Injections, Intramuscular; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine

1995
Comparison of treatment regimens for pediatric lymphoblastic non-Hodgkin's lymphoma: a Childrens Cancer Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cause of Death; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Thioguanine; Treatment Failure; Vincristine

1995
Aminophylline for methotrexate-induced neurotoxicity.
    Lancet (London, England), 1995, Mar-04, Volume: 345, Issue:8949

    Topics: Adenosine; Adolescent; Aminophylline; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1995
Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X. Medical Research Council Working Party on Childhood Leukaemia.
    Lancet (London, England), 1995, Jan-21, Volume: 345, Issue:8943

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brain; Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Infant; Injections, Spinal; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Sex Factors; Survival Rate; Treatment Outcome; United Kingdom

1995
Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Münster Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Clinical Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Etoposide; Follow-Up Studies; Humans; Ifosfamide; Infant; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Time Factors

1995
Neuropsychological effects of cranial irradiation in young children with acute lymphoblastic leukemia 9 months after diagnosis. The Children's Cancer Group.
    Archives of neurology, 1995, Volume: 52, Issue:2

    Topics: Adolescent; Brain; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance

1995
Late intensification therapy in adult acute lymphoid leukemia: long-term follow-up of the Southeastern Cancer Study Group experience.
    Leukemia & lymphoma, 1994, Volume: 15, Issue:1-2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Life Tables; Male; Methotrexate; Middle Aged; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Remission Induction; Salvage Therapy; Survival Analysis; Treatment Outcome; United States; Vincristine

1994
High-dose Ara-C for remission induction and consolidation of previously untreated adults with ALL or lymphoblastic lymphoma.
    Annals of hematology, 1995, Volume: 70, Issue:2

    Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cytarabine; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Time Factors; Vincristine

1995
Prolonged intrathecal chemotherapy replacing cranial irradiation in high-risk acute lymphatic leukaemia: long-term follow up with cerebral computed tomography scans and endocrinological studies.
    European journal of pediatrics, 1995, Volume: 154, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Cranial Irradiation; Cytarabine; Disease-Free Survival; Female; Follow-Up Studies; Growth; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Pituitary Hormones, Anterior; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thyroid Hormones; Tomography, X-Ray Computed

1995
Cerebrospinal fluid drug levels of leukemic children receiving intravenous 5 g/m2 methotrexate.
    Leukemia & lymphoma, 1994, Volume: 14, Issue:1-2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Child; Child, Preschool; Cytarabine; Female; Follow-Up Studies; Humans; Infant; Infusions, Intravenous; Leucovorin; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors

1994
Adult acute lymphoblastic leukemia: results of an aggressive regimen in India.
    Leukemia & lymphoma, 1994, Volume: 14, Issue:3-4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Administration Schedule; Female; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine

1994
[Clinical trial of protocol-AL851 for children with high-risk acute lymphoblastic leukemia. Kyushu Yamaguchi Children's Cancer Study Group (KYCCSG)].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1994, Volume: 35, Issue:9

    Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk; Survival Rate

1994
Improvement in treatment of childhood acute lymphoblastic leukemia: a 10-year study by the Children's Cancer and Leukemia Study Group.
    International journal of hematology, 1994, Volume: 59, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Japan; Life Tables; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate

1994
Patient characteristics associated with high-risk methotrexate concentrations and toxicity.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:8

    Topics: Child; Child, Preschool; Female; Fluid Therapy; Humans; Hydrogen-Ion Concentration; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Urine; Vomiting

1994
Comparison of two schedules of intermediate-dose methotrexate and cytarabine consolidation therapy for childhood B-precursor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Female; Humans; Infant; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; United States

1994
[l-folinic acid versus racemic folinic acid in the treatment of leukemia in children with high dose of methotrexate].
    Bulletin du cancer, 1993, Volume: 80, Issue:4

    Topics: Adolescent; Antidotes; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stereoisomerism

1993
Importance of effective central nervous system therapy in isolated bone marrow relapse of childhood acute lymphoblastic leukemia. BFM (Berlin-Frankfurt-Münster) Relapse Study Group.
    Blood, 1994, Jun-15, Volume: 83, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Rate

1994
Results of Medical Research Council trial UKALL IX in acute lymphoblastic leukaemia in adults: report from the Medical Research Council Working Party on Adult Leukaemia.
    British journal of haematology, 1993, Volume: 85, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Daunorubicin; Female; Follow-Up Studies; Humans; Leucovorin; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Sex Factors; Vincristine

1993
Plasma and urine levels of methotrexate and 7-hydroxymethotrexate in children with ALL during maintenance therapy with weekly oral methotrexate.
    Medical and pediatric oncology, 1994, Volume: 22, Issue:3

    Topics: Administration, Oral; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Humans; Lymphoma, Non-Hodgkin; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Regression Analysis; Remission Induction

1994
Cyclosporine combined with methylprednisolone or methotrexate in prophylaxis of moderate to severe acute graft-versus-host disease.
    Bone marrow transplantation, 1993, Volume: 12, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Bone Marrow Transplantation; Cyclosporine; Drug Therapy, Combination; Female; Graft vs Host Disease; Humans; Incidence; Japan; Leukemia, Myeloid; Male; Methotrexate; Methylprednisolone; Middle Aged; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Severity of Illness Index

1993
Circadian time-dependent response of childhood lymphoblastic leukemia to chemotherapy: a long-term follow-up study of survival.
    Chronobiology international, 1993, Volume: 10, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Circadian Rhythm; Drug Administration Schedule; Follow-Up Studies; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Recurrence; Regression Analysis; Survival Analysis; Time Factors; Vincristine

1993
Follow-up of the first two successive German multicentre trials for adult ALL (01/81 and 02/84). German Adult ALL Study Group.
    Leukemia, 1993, Volume: 7 Suppl 2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Administration Schedule; Follow-Up Studies; Humans; Mediastinum; Mercaptopurine; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Survival Analysis; Teniposide; Vincristine

1993
Treatment results of three consecutive Brazilian cooperative childhood ALL protocols: GBTLI-80, GBTLI-82 and -85. ALL Brazilian Group.
    Leukemia, 1993, Volume: 7 Suppl 2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Drug Administration Schedule; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Teniposide; Vincristine

1993
Chemotherapy versus allogeneic bone marrow transplantation in adults with acute lymphoblastic leukemia.
    Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Cyclosporine; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Analysis; Transplantation, Homologous; Whole-Body Irradiation

1993
Prevention of CNS disease in intermediate-risk acute lymphoblastic leukemia: comparison of cranial radiation and intrathecal methotrexate and the importance of systemic therapy: a Childrens Cancer Group report.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Injections, Spinal; Life Tables; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Survival Analysis

1993
Improved outcome with delayed intensification for children with acute lymphoblastic leukemia and intermediate presenting features: a Childrens Cancer Group phase III trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Drug Administration Schedule; Female; Humans; Infant; Injections, Spinal; Life Tables; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Survival Analysis; Treatment Outcome

1993
Randomized comparison of 36-hour intermediate-dose versus 4-hour high-dose methotrexate infusions for remission induction in relapsed childhood acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

1993
[Results of the CCLSG high risk ALL 874 protocol in childhood acute lymphoblastic leukemia. Children's Cancer and Leukemia Study Group].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1993, Volume: 34, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Risk; Vincristine

1993
Severe toxicity limits intensification of induction therapy for acute lymphoblastic leukemia.
    Leukemia, 1993, Volume: 7, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Idarubicin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Vincristine

1993
Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.
    The Journal of clinical investigation, 1996, Jan-01, Volume: 97, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Stomatitis

1996
Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia.
    Leukemia, 1996, Volume: 10, Issue:1

    Topics: Adolescent; Allopurinol; Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Humans; Infant; Linear Models; Lymphocytes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines

1996
A randomized phase-III study of the efficacy of granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia. Berlin-Frankfurt-Münster Study Group.
    Blood, 1996, Apr-15, Volume: 87, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Etoposide; Female; Fever; Filgrastim; Gastrointestinal Diseases; Germany; Granulocyte Colony-Stimulating Factor; Hematologic Diseases; Humans; Ifosfamide; Infant; Infection Control; Life Tables; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prospective Studies; Recombinant Proteins; Risk; Survival Analysis; Thioguanine; Vincristine; Vindesine

1996
Randomized comparison of moderate-dose methotrexate infusions to oral methotrexate in children with intermediate risk acute lymphoblastic leukemia: a Childrens Cancer Group study.
    Medical and pediatric oncology, 1996, Volume: 27, Issue:1

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Injections, Spinal; Leucovorin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Survival Analysis; Vincristine

1996
The GIMEMA ALL 0183 trial: analysis of 10-year follow-up. GIMEMA Cooperative Group, Italy.
    British journal of haematology, 1996, Volume: 92, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Follow-Up Studies; Humans; Idarubicin; Male; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Analysis; Survival Rate

1996
Cytoreduction and prognosis in acute lymphoblastic leukemia--the importance of early marrow response: report from the Childrens Cancer Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Combined Modality Therapy; Cyclophosphamide; Daunorubicin; Disease-Free Survival; Humans; Lymphocyte Count; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Vincristine

1996
Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small noncleaved-cell lymphoma: a pediatric oncology group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infant; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Treatment Outcome; Vincristine

1996
Relationship between minimal residual disease and outcome in adult acute lymphoblastic leukemia.
    Blood, 1996, Jun-15, Volume: 87, Issue:12

    Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Bone Marrow Transplantation; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Neoplasm; Etoposide; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Humans; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm, Residual; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Survival Analysis; Treatment Outcome; Vincristine

1996
Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92.
    Leukemia, 1996, Volume: 10, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Base Sequence; Child; Child, Preschool; Chromosomes, Human, Pair 22; Chromosomes, Human, Pair 9; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Fusion Proteins, bcr-abl; Germany; Humans; Incidence; Infant; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mercaptopurine; Methotrexate; Molecular Sequence Data; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Transcription, Genetic; Translocation, Genetic; Vincristine

1996
[Chemotherapy for B lymphoid malignancy in childhood--results in BLK88 protocol].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1996, Volume: 37, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Doxorubicin; Female; Humans; Injections, Spinal; Lymphoma, B-Cell; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

1996
Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group.
    Neuropediatrics, 1996, Volume: 27, Issue:4

    Topics: Age of Onset; Analysis of Variance; Austria; Chi-Square Distribution; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Evoked Potentials, Visual; Female; Follow-Up Studies; Germany; Humans; Intelligence; Male; Methotrexate; Odds Ratio; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors

1996
Low incidence of CNS relapse with cranial radiotherapy and intrathecal methotrexate in acute lymphoblastic leukemia.
    Indian pediatrics, 1996, Volume: 33, Issue:7

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Female; Humans; Leukemic Infiltration; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1996
Acute lymphoblastic leukemia in children: nonrandomized comparison of conventional vs. intensive chemotherapy at the National Cancer Institute of Colombia.
    Medical and pediatric oncology, 1997, Volume: 28, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Administration Schedule; Feasibility Studies; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Treatment Outcome; Vincristine

1997
Intermediate-dose methotrexate versus cranial irradiation in childhood acute lymphoblastic leukemia: a ten-year follow-up.
    Medical and pediatric oncology, 1997, Volume: 28, Issue:2

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

1997
Monitoring of methotrexate and 7-hydroxymethotrexate in saliva from children with acute lymphoblastic leukemia receiving high-dose consolidation treatment: relation to oral mucositis.
    Anti-cancer drugs, 1997, Volume: 8, Issue:2

    Topics: Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Stomatitis; Time Factors

1997
Eighty-one percent event-free survival in advanced Burkitt's lymphoma/leukemia: no differences in outcome between pediatric and adult patients treated with the same intensive pediatric protocol.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8 Suppl 1

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Treatment Outcome; Vincristine

1997
B-lineage acute lymphoblastic leukemia of childhood. An institutional experience.
    Archives of medical research, 1997,Summer, Volume: 28, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Burkitt Lymphoma; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Female; Humans; Immunophenotyping; Infant; Life Tables; Male; Mercaptopurine; Methotrexate; Neprilysin; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Risk Factors; Survival Analysis; Teniposide; Treatment Outcome; Vincristine

1997
Autologous transplantation with CD52 monoclonal antibody-purged marrow for acute lymphoblastic leukemia: long-term follow-up.
    Leukemia & lymphoma, 1997, Volume: 25, Issue:5-6

    Topics: Adolescent; Adult; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Bone Marrow Transplantation; CD52 Antigen; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Glycoproteins; Humans; Male; Melphalan; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Time Factors; Transplantation, Autologous; Whole-Body Irradiation

1997
Age-adapted induction treatment of acute lymphoblastic leukemia in the elderly and assessment of maintenance with interferon combined with chemotherapy. A multicentric prospective study in forty patients. French Group for Treatment of Adult Acute Lymphobl
    Leukemia, 1997, Volume: 11, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Daunorubicin; Disease-Free Survival; Female; Humans; Interferons; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Steroids; Vincristine

1997
Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies.
    Leukemia, 1997, Volume: 11, Issue:11

    Topics: Allopurinol; Antimetabolites; Antineoplastic Agents; Child; Child, Preschool; Female; Humans; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Urate Oxidase; Uric Acid

1997
Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.
    British journal of clinical pharmacology, 1997, Volume: 44, Issue:5

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Cytarabine; Dexamethasone; Erythrocytes; Etoposide; Female; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine; Vincristine

1997
Intensified therapy for infants with acute lymphoblastic leukemia: results from the Dana-Farber Cancer Institute Consortium.
    Cancer, 1997, Dec-15, Volume: 80, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Core Binding Factor Alpha 2 Subunit; Cytarabine; Disease-Free Survival; DNA-Binding Proteins; DNA, Neoplasm; Female; Histone-Lysine N-Methyltransferase; Humans; Infant; Infant, Newborn; Male; Mercaptopurine; Methotrexate; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proto-Oncogenes; Remission Induction; Survival Rate; Transcription Factors; Treatment Outcome; Vincristine

1997
A comparative study of the long term psychosocial functioning of childhood acute lymphoblastic leukemia survivors treated by intrathecal methotrexate with or without cranial radiation.
    Cancer, 1998, Jan-01, Volume: 82, Issue:1

    Topics: Achievement; Adolescent; Adult; Antimetabolites, Antineoplastic; Behavior; Body Image; Child; Clinical Trials, Phase III as Topic; Cranial Irradiation; Disease-Free Survival; Education; Employment; Female; Humans; Injections, Intravenous; Injections, Spinal; Interviews as Topic; Longitudinal Studies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Self Concept; Sexual Behavior; Social Adjustment; Social Behavior; Stress, Psychological; Survivors; Telephone

1998
Intermediate-dose intravenous methotrexate with intravenous mercaptopurine is superior to repetitive low-dose oral methotrexate with intravenous mercaptopurine for children with lower-risk B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:1

    Topics: Administration, Oral; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child, Preschool; Female; Humans; Infusions, Intravenous; Leucovorin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Remission Induction; Sex Factors; Treatment Failure

1998
Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia.
    The New England journal of medicine, 1998, Feb-19, Volume: 338, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Infant; Leukemia, B-Cell; Male; Metabolic Clearance Rate; Methotrexate; Patient Care Planning; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Prospective Studies; Remission Induction; Survival Analysis; Teniposide

1998
Response of children with high-risk acute lymphoblastic leukemia treated with and without cranial irradiation: a report from the Children's Cancer Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Remission Induction; Survival Analysis

1998
Estimated 6-year event-free survival of 55% in 60 consecutive adult acute lymphoblastic leukemia patients treated with an intensive phase II protocol based on high induction dose of daunorubicin.
    Leukemia, 1998, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine

1998
Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:4

    Topics: Antidotes; Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Demyelinating Diseases; Drug Interactions; Humans; Infant; Leucovorin; Methionine; Methotrexate; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Tetrahydrofolates

1998
Profound abnormality of the B/T lymphocyte ratio during chemotherapy for pediatric acute lymphoblastic leukemia.
    Leukemia, 1998, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; CD4 Lymphocyte Count; Child; Child, Preschool; Female; Flow Cytometry; Humans; Immunoglobulin G; Immunoglobulin M; Lymphocyte Subsets; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; T-Lymphocytes

1998
Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy--a Pediatric Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:5

    Topics: Acute Disease; Administration, Oral; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Injections, Spinal; Leucovorin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Tomography, X-Ray Computed

1998
Oral versus intravenous methotrexate: another opinion.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:6

    Topics: Administration, Oral; Child; Drug Administration Schedule; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1998
Improved survival with early intensification: combined results from the Medical Research Council childhood ALL randomised trials, UKALL X and UKALL XI. Medical Research Council Working Party on Childhood Leukaemia.
    Leukemia, 1998, Volume: 12, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Daunorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Thioguanine; Vincristine

1998
Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia.
    Leukemia, 1998, Volume: 12, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Female; Humans; Incidence; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1998
Analysis of the immunophenotype of children treated on the Medical Research Council United Kingdom Acute Lymphoblastic Leukaemia Trial XI (MRC UKALLXI). Medical Research Council Childhood Leukaemia Working Party.
    Leukemia, 1998, Volume: 12, Issue:8

    Topics: Adolescent; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers, Tumor; CD13 Antigens; Child; Child, Preschool; Daunorubicin; Disease-Free Survival; Female; Humans; Immunophenotyping; Infant; Leukocyte Count; Male; Methotrexate; Neprilysin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Sialic Acid Binding Ig-like Lectin 3; Vincristine

1998
Is high dose methotrexate without irradiation of the brain sufficiently effective in prevention of CNS disease in children with acute lymphoblastic leukemia?
    Neoplasma, 1998, Volume: 45, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk

1998
Changes in red blood cell methotrexate pharmacology and their impact on outcome when cytarabine is infused with methotrexate in the treatment of acute lymphocytic leukemia in children: a pediatric oncology group study.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Erythrocytes; Humans; Infant; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies

1996
Intensive BFM chemotherapy for childhood ALL: interim analysis of the AIEOP-ALL 91 study. Associazione Italiana Ematologia Oncologia Pediatrica.
    Haematologica, 1998, Volume: 83, Issue:9

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Chromosome Aberrations; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Humans; Infant; Italy; Leucovorin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Risk; Thioguanine; Treatment Outcome; Vincristine

1998
[Studies of childhood non-Hodgkin's lymphoma--treatment results with the CCLSG NHL 960 protocol. Children's Cancer and Leukemia Study Group (CCLSG)].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1998, Volume: 39, Issue:11

    Topics: Adolescent; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Etoposide; Female; Humans; Hydrocortisone; Infant; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine

1998
Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation.
    Blood, 1999, Mar-01, Volume: 93, Issue:5

    Topics: Carrier Proteins; Cell Lineage; Child; Child, Preschool; Chromosomes, Human, Pair 21; Humans; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Ploidies; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

1999
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
    Blood, 1999, Mar-01, Volume: 93, Issue:5

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; gamma-Glutamyl Hydrolase; Glutamic Acid; Humans; Infant; Male; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1999
Improvement in CNS protective treatment in non-high-risk childhood acute lymphoblastic leukemia: report from the Japanese Children's Cancer and Leukemia Study Group.
    Medical and pediatric oncology, 1999, Volume: 32, Issue:4

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Infant; Injections, Spinal; Japan; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Treatment Outcome

1999
Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.
    Blood, 1999, May-01, Volume: 93, Issue:9

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Remission Induction; Survival Rate

1999
Improved outcome for acute lymphoblastic leukemia in children of a developing country: results of the Chilean National Trial PINDA 87.
    Medical and pediatric oncology, 1999, Volume: 33, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chile; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Developing Countries; Female; Humans; Immunophenotyping; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Survival Analysis; Vincristine

1999
Metabolites of mercaptopurine in red blood cells: a relationship between 6-thioguanine nucleotides and 6-methylmercaptopurine metabolite concentrations in children with lymphoblastic leukemia.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 1999, Volume: 8, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Female; Guanine Nucleotides; Humans; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine

1999
Long-term follow-up results of adult patients with acute lymphocytic leukemia or lymphoblastic lymphoma treated with short-term, alternating non-cross-resistant chemotherapy: Japan Clinical Oncology Group Study 8702. Lymphoma Study Group.
    Japanese journal of clinical oncology, 1999, Volume: 29, Issue:7

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Survival Analysis; Treatment Outcome; Vincristine

1999
Persistence of peripheral blood and bone marrow blasts during remission induction in adult acute lymphoblastic leukemia confers a poor prognosis depending on treatment intensity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Humans; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Time Factors; Vincristine

1999
Combination therapy with methotrexate, vincristine, polyethylene-glycol conjugated-asparaginase, and prednisone in the treatment of patients with refractory or recurrent acute lymphoblastic leukemia.
    Cancer, 1999, Oct-01, Volume: 86, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Drug Administration Schedule; Enzymes, Immobilized; Female; Humans; L-Lactate Dehydrogenase; Male; Methotrexate; Middle Aged; Philadelphia Chromosome; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Treatment Outcome; Vincristine

1999
A randomised dose-comparison trial of granisetron in preventing emesis in children with leukaemia receiving emetogenic chemotherapy.
    European journal of cancer (Oxford, England : 1990), 1999, Volume: 35, Issue:7

    Topics: Adolescent; Antiemetics; Antineoplastic Agents; Child; Child, Preschool; Cross-Over Studies; Cytarabine; Dose-Response Relationship, Drug; Female; Granisetron; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1999
[Prevention of neuroleukemia by intrathecal administration of cytosar and methotrexate in acute lymphoblastic leukemia in adults].
    Terapevticheskii arkhiv, 1999, Volume: 71, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Drug Therapy, Combination; Female; Humans; Immunophenotyping; Injections, Spinal; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk Factors; Treatment Outcome

1999
Effective preventive central nervous system therapy with extended triple intrathecal therapy and the modified ALL-BFM 86 chemotherapy program in an enlarged non-high risk group of children and adolescents with non-B-cell acute lymphoblastic leukemia: the
    Cancer, 2000, Jan-01, Volume: 88, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cytarabine; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Israel; Life Tables; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Risk; Treatment Outcome

2000
Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report.
    Blood, 2000, Jan-15, Volume: 95, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cranial Irradiation; Disease-Free Survival; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Probability; Remission Induction; Time Factors

2000
Effects of G-CSF and high-dose methylprednisolone on peripheral stem cells, serum IL-3 levels and hematological parameters in acute lymphoblastic leukemia patients with neutropenia: a pilot study.
    Leukemia research, 2000, Volume: 24, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Etoposide; Glucocorticoids; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Interleukin-3; Methotrexate; Methylprednisolone; Neutropenia; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine

2000
Intensification with intermediate-dose intravenous methotrexate is effective therapy for children with lower-risk B-precursor acute lymphoblastic leukemia: A Pediatric Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:6

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Survival Analysis

2000
Benefit of intensified treatment for all children with acute lymphoblastic leukaemia: results from MRC UKALL XI and MRC ALL97 randomised trials. UK Medical Research Council's Working Party on Childhood Leukaemia.
    Leukemia, 2000, Volume: 14, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; Humans; Infant; Infections; Male; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Proportional Hazards Models; Remission Induction; Risk; Survival Analysis; Thioguanine; Treatment Outcome; Vincristine

2000
Six months of maintenance chemotherapy after intensified treatment for acute lymphoblastic leukemia of childhood.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:7

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk Factors; Treatment Outcome

2000
Use of recombinant human granulocyte colony-stimulating factor to increase chemotherapy dose-intensity: a randomized trial in very high-risk childhood acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Infant; Infant, Newborn; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recombinant Proteins; Thrombocytopenia; Treatment Outcome; Vincristine

2000
[Treatment of adult acute lymphoblastic leukemia by KHALL-93--long-term outcome].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Treatment Outcome

2000
Comparison of the L10M consolidation regimen to an alternative regimen including escalating methotrexate/L-asparaginase for adult acute lymphoblastic leukemia: a Southwest Oncology Group Study.
    Leukemia, 2001, Volume: 15, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Disease-Free Survival; Dose-Response Relationship, Drug; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Analysis

2001
6-mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high-dose methotrexate in children with acute lymphoblastic leukemia.
    Leukemia, 2001, Volume: 15, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2001
Effects of high-dose methotrexate on the hemostatic system in childhood acute lymphoblastic leukemia.
    Medical and pediatric oncology, 2001, Volume: 36, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Blood Coagulation Disorders; Blood Coagulation Factor Inhibitors; Blood Coagulation Factors; Blood Coagulation Tests; Child; Child, Preschool; Female; Hemostasis; Humans; Male; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2001
Value of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Apr-01, Volume: 19, Issue:7

    Topics: Actuarial Analysis; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System; Child; Child, Preschool; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Synergism; Europe; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Injections, Spinal; Leukemic Infiltration; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Regression Analysis; Risk; Vincristine

2001
Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol.
    British journal of haematology, 2001, Volume: 113, Issue:1

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Female; Humans; Infant; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Risk Factors; Sex Factors; Thioguanine; United Kingdom; Vincristine

2001
The Société Française d'Oncologie Pédiatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia.
    Blood, 2001, Jun-01, Volume: 97, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Humans; Hydrocortisone; Infant; Leucovorin; Lymphoma, B-Cell; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Remission Induction; Survival Rate; Vincristine

2001
Daunorubicin continuous infusion induces more toxicity than bolus infusion in acute lymphoblastic leukemia induction regimen: a randomized study.
    Leukemia, 2001, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Etoposide; Female; Gram-Negative Bacterial Infections; Humans; Immunocompromised Host; Infusions, Intravenous; Injections, Intravenous; Life Tables; Male; Methotrexate; Middle Aged; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Thrombocytopenia; Treatment Outcome; Vincristine

2001
Risk-oriented postremission strategies in adult acute lymphoblastic leukemia: prospective confirmation of anthracycline activity in standard-risk class and role of hematopoietic stem cell transplants in high-risk groups.
    The hematology journal : the official journal of the European Haematology Association, 2001, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Idarubicin; Male; Melphalan; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Transplantation, Homologous; Whole-Body Irradiation

2001
Metabolic functions of the liver during chemotherapy in children with acute lymphoblastic leukemia.
    International journal of clinical pharmacology and therapeutics, 2001, Volume: 39, Issue:6

    Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antipyrine; Child; Child, Preschool; Half-Life; Humans; Liver; Liver Function Tests; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2001
Outcome of acute lymphoblastic leukemia in children with AL90 regimen: impact of response to treatment and sex difference on prognostic factors.
    Medical and pediatric oncology, 2001, Volume: 37, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Drug Administration Schedule; Etoposide; Female; Humans; Immunophenotyping; Infant; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Radiotherapy, Adjuvant; Remission Induction; Risk; Risk Factors; Severity of Illness Index; Sex Factors; Survival Analysis; Treatment Outcome; Vincristine

2001
Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Oct-15, Volume: 19, Issue:20

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Infections; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survival Analysis; Thrombocytopenia; Vincristine

2001
Favorable outcome for children and adolescents with T-cell lymphoblastic lymphoma with an intensive ALL-type therapy without local radiotherapy.
    Annals of hematology, 2001, Volume: 80 Suppl 3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Austria; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Germany; Humans; Immunophenotyping; Infant; Life Tables; Lymphoma, T-Cell; Male; Mercaptopurine; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiotherapy, Adjuvant; Remission Induction; Thioguanine; Treatment Outcome; Vincristine

2001
Less intense conditioning with fludarabine, cyclophosphamide, idarubicin and etoposide (FCIE) followed by allogeneic unselected peripheral blood stem cell transplantation in elderly patients with leukemia.
    Leukemia, 2002, Volume: 16, Issue:4

    Topics: Adult; Aged; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Cyclosporine; Etoposide; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Idarubicin; Immunosuppressive Agents; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Chronic-Phase; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Transplantation Conditioning; Transplantation, Homologous; Vidarabine

2002
Quantitative MRI assessment of leukoencephalopathy.
    Magnetic resonance in medicine, 2002, Volume: 47, Issue:5

    Topics: Adult; Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child; Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2002
Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
    Therapeutic drug monitoring, 2002, Volume: 24, Issue:3

    Topics: Adult; Age Factors; Antimetabolites, Antineoplastic; Azathioprine; Child; Drug Therapy, Combination; Erythrocytes; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methotrexate; Methyltransferases; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioinosine; Thionucleotides

2002
Adult lymphoblastic lymphoma: high incidence of central nervous system relapse in patients treated with the Stanford University protocol.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1992, Volume: 3, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Treatment Outcome

1992
Treatment of acute lymphoblastic leukaemia (ALL).
    European journal of haematology, 1992, Volume: 49, Issue:2

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infusions, Intravenous; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Analysis; Vincristine

1992
Treatment of advanced stage T cell lymphoblastic lymphoma: results of the United Kingdom Children's Cancer Study Group (UKCCSG) protocol 8503.
    British journal of haematology, 1992, Volume: 82, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Daunorubicin; Humans; Infant; Mercaptopurine; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination; Vincristine

1992
Efficacy of intrathecal methotrexate with and without cranial radiotherapy in preventing central nervous system relapses in acute lymphocytic leukemia.
    Indian pediatrics, 1992, Volume: 29, Issue:7

    Topics: Adolescent; Brain; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Treatment Outcome

1992
Red blood cell methotrexate and folate levels in children with acute lymphoblastic leukemia undergoing therapy: a Pediatric Oncology Group pilot study.
    Cancer chemotherapy and pharmacology, 1992, Volume: 31, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Drug Monitoring; Erythrocytes; Folic Acid; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors

1992
F-MACHOP in advanced aggressive lymphoma.
    Leukemia & lymphoma, 1992, Volume: 7, Issue:3

    Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Fluorouracil; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

1992
IgG subclass imbalance in children with acute lymphoblastic leukemia receiving maintenance chemotherapy.
    Acta paediatrica Japonica : Overseas edition, 1992, Volume: 34, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dysgammaglobulinemia; Female; Humans; IgG Deficiency; Immune Tolerance; Immunoglobulin Fragments; Immunoglobulin G; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

1992
Long-term neuropsychologic sequelae of childhood leukemia: comparison of two CNS prophylactic regimens.
    International journal of radiation oncology, biology, physics, 1992, Volume: 24, Issue:1

    Topics: Adolescent; Age Factors; Brain; Brain Neoplasms; Child; Cognition Disorders; Combined Modality Therapy; Cytarabine; Female; Humans; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

1992
Late intensification therapy in adult acute lymphoid leukemia. The Southeastern Cancer Study Group Experience.
    American journal of clinical oncology, 1992, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Vincristine

1992
Impact of three methods of treatment intensification on acute lymphoblastic leukemia in children: long-term results of St Jude total therapy study X.
    Leukemia, 1992, Volume: 6, Issue:2

    Topics: Child; Child, Preschool; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Methotrexate; Outcome Assessment, Health Care; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction

1992
The relationship of sex and treatment modality to neuropsychologic outcome in childhood acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:5

    Topics: Adolescent; Analysis of Variance; Child; Child, Preschool; Cognition; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Intelligence; Intelligence Tests; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors

1992
Treatment of acute lymphoblastic leukemia French protocol Fralle 83-87.
    Leukemia, 1992, Volume: 6 Suppl 2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Drug Administration Schedule; Female; France; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Risk Factors; Vincristine; Vindesine

1992
MRC UKALL X. The UK protocol for childhood ALL: 1985-1990. The Medical Research Council Working Party on Childhood Leukaemia.
    Leukemia, 1992, Volume: 6 Suppl 2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Clinical Protocols; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; United Kingdom

1992
Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience.
    Leukemia, 1992, Volume: 6 Suppl 2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Administration Schedule; Humans; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Thioguanine; Vincristine

1992
Early intensification followed by allo-BMT or auto-BMT or a second intensification in adult ALL: a randomized multicenter study.
    Leukemia, 1992, Volume: 6 Suppl 2

    Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Feasibility Studies; Humans; Italy; Methotrexate; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Transplantation, Autologous; Transplantation, Homologous; Vincristine

1992
Marked increase in veno-occlusive disease of the liver associated with methotrexate use for graft-versus-host disease prophylaxis in patients receiving busulfan/cyclophosphamide.
    Blood, 1992, May-15, Volume: 79, Issue:10

    Topics: Actuarial Analysis; Adult; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Female; Follow-Up Studies; Graft vs Host Disease; Hepatic Veno-Occlusive Disease; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Whole-Body Irradiation

1992
[Second cessation of therapy in children with acute lymphoblastic leukemia].
    Acta haematologica Polonica, 1992, Volume: 23, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Infant; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Time Factors; Vincristine

1992
Total body irradiation with or without lung shielding for allogeneic bone marrow transplantation.
    Bone marrow transplantation, 1992, Volume: 9, Issue:5

    Topics: Adult; Bone Marrow Transplantation; Cyclophosphamide; Dose-Response Relationship, Radiation; Female; Graft vs Host Disease; Humans; Incidence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lung; Lung Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiation Protection; Transplantation, Homologous; Whole-Body Irradiation

1992
Deterioration of intellect among children surviving leukemia: IQ test changes modify estimates of treatment toxicity.
    Journal of consulting and clinical psychology, 1992, Volume: 60, Issue:3

    Topics: Age Factors; Child; Child, Preschool; Female; Humans; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Wechsler Scales

1992
[Treatment of acute lymphoblastic leukemia in children. Results of the FRALLE 83 protocol].
    Archives francaises de pediatrie, 1991, Volume: 48, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Clinical Protocols; Cyclophosphamide; Daunorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Vincristine

1991
Retrospective analysis of late intensification therapy with high-dose methotrexate for standard-risk acute lymphoblastic leukemia in childhood (CCLSG-S811 study). The Children's Cancer and Leukemia Study Group.
    International journal of hematology, 1991, Volume: 54, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cranial Irradiation; Humans; Infant; Leucovorin; Life Tables; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Retrospective Studies; Survival Rate; Vincristine

1991
Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (Protocol 81-01 update).
    Blood, 1991, Nov-15, Volume: 78, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Follow-Up Studies; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Time Factors; Treatment Outcome; Vincristine

1991
Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission after intensive primary and relapse therapy according to the BFM- and CoALL-protocols: results of the German Cooperative Study.
    Blood, 1991, Nov-15, Volume: 78, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Cyclophosphamide; Cyclosporine; Daunorubicin; Etoposide; Follow-Up Studies; Graft vs Host Disease; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Time Factors; Transplantation, Homologous; Vincristine; Whole-Body Irradiation

1991
How much is too much? Folinic acid rescue dose in children with acute lymphoblastic leukaemia.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Retrospective Studies; Risk Factors

1991
The influence of serum methotrexate concentrations and drug dosage on outcome in childhood acute lymphoblastic leukaemia.
    British journal of cancer, 1991, Volume: 64, Issue:1

    Topics: Administration, Oral; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Injections, Intramuscular; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Random Allocation

1991
Six-year experience with a comprehensive approach to the treatment of recurrent childhood acute lymphoblastic leukemia (ALL-REZ BFM 85). A relapse study of the BFM group.
    Blood, 1991, Sep-01, Volume: 78, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Testicular Neoplasms

1991
Intellectual function in long-term survivors of childhood acute lymphoblastic leukemia: protective effect of pre-irradiation methotrexate? A Childrens Cancer Study Group study.
    Medical and pediatric oncology, 1991, Volume: 19, Issue:6

    Topics: Asparaginase; Brain; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Infant; Injections, Spinal; Intelligence; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiation-Protective Agents; Radiation, Ionizing; Radiography; Radiotherapy; Regression Analysis; Vincristine

1991
High survival rate in advanced-stage B-cell lymphomas and leukemias without CNS involvement with a short intensive polychemotherapy: results from the French Pediatric Oncology Society of a randomized trial of 216 children.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Female; Follow-Up Studies; Humans; Infant; Lymphoma, B-Cell; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Survival Rate; Vincristine

1991
HiC-COM: a 2-month intensive chemotherapy regimen for children with stage III and IV Burkitt's lymphoma and B-cell acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoplasm Staging; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Vincristine

1991
A phase II study of combined methotrexate and teniposide infusions prior to reinduction therapy in relapsed childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Drug Evaluation; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Teniposide

1991
Comparison of neuropsychologic functioning and clinical indicators of neurotoxicity in long-term survivors of childhood leukemia given cranial radiation or parenteral methotrexate: a prospective study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Electroencephalography; Female; Humans; Infusions, Parenteral; Intelligence Tests; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiation Injuries

1991
A pilot study of intermediate-dose methotrexate and cytosine arabinoside, "spread-out" or "up-front," in continuation therapy for childhood non-T, non-B acute lymphoblastic leukemia. A Pediatric Oncology Group study.
    Cancer, 1991, Feb-01, Volume: 67, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Female; Fever; Humans; Infant; Infections; Length of Stay; Leukocyte Count; Male; Methotrexate; Neutropenia; Pilot Projects; Platelet Count; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Survival Rate

1991
Autologous bone marrow transplantation for high-grade lymphoid malignancy using melphalan/irradiation conditioning without marrow purging or cryopreservation. The Northern Regional Bone Marrow Transplant Group.
    Blood, 1991, Apr-01, Volume: 77, Issue:7

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Cryopreservation; Female; Follow-Up Studies; Humans; Lymphoma, Non-Hodgkin; Male; Melphalan; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Transplantation, Autologous

1991
Parental report of everyday cognitive abilities among children treated for acute lymphoblastic leukemia.
    Journal of pediatric psychology, 1991, Volume: 16, Issue:1

    Topics: Adolescent; Brain Neoplasms; Child; Cognition Disorders; Cranial Irradiation; Female; Humans; Injections, Spinal; Intelligence Tests; Learning Disabilities; Male; Methotrexate; Neuropsychological Tests; Parents; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1991
Monthly pulses of vincristine and prednisone prevent bone marrow and testicular relapse in low-risk childhood acute lymphoblastic leukemia: a report of the CCG-161 study by the Childrens Cancer Study Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Brain Neoplasms; Child, Preschool; Combined Modality Therapy; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Random Allocation; Recurrence; Remission Induction; Survival Rate; Testicular Neoplasms; Vincristine

1991
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study.
    Leukemia, 1991, Volume: 5, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Daunorubicin; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Methotrexate; Middle Aged; Mitoxantrone; Nervous System Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1991
Results of Medical Research Council Childhood Leukaemia Trial UKALL VIII (report to the Medical Research Council on behalf of the Working Party on Leukaemia in Childhood).
    British journal of haematology, 1991, Volume: 78, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Random Allocation; United Kingdom; Vincristine

1991
A prospective comparison of neuropsychologic performance of children surviving leukemia who received 18-Gy, 24-Gy, or no cranial irradiation.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:8

    Topics: Adolescent; Age Factors; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Dose-Response Relationship, Radiation; Female; Humans; Infant; Intelligence; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Psychomotor Performance; Radiotherapy Dosage; Remission Induction; Time Factors; Verbal Behavior

1991
CSF drug levels for children with acute lymphoblastic leukemia treated by 5 g/m2 methotrexate. A study from the EORTC Children's Leukemia Cooperative Group.
    European journal of cancer (Oxford, England : 1990), 1990, Volume: 26, Issue:4

    Topics: Adolescent; Age Factors; Analysis of Variance; Child; Child, Preschool; Europe; Female; Humans; Infant; Infusions, Intravenous; Male; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1990
Treatment of relapsed acute lymphocytic leukemia in adults.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Brain Neoplasms; Combined Modality Therapy; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Female; Germany, West; Humans; Ifosfamide; Leucovorin; Life Tables; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Spinal Cord Neoplasms; Teniposide; Testicular Neoplasms; Vindesine

1990
Impact of early intensive reinduction therapy on event-free survival in children with low-risk acute lymphoblastic leukemia.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Daunorubicin; Dexamethasone; Doxorubicin; Germany, West; Humans; Leucovorin; Life Tables; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Randomized Controlled Trials as Topic; Risk; Survival Rate; Thioguanine; Vincristine

1990
Improved prognosis for childhood acute lymphocytic leukemia with very high white blood cell count (greater than 100/nl) with rotation of non-cross-resistant drug combinations.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Germany, West; Humans; Infant; Infant, Newborn; Leukocyte Count; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Randomized Controlled Trials as Topic; Risk; Survival Rate; Teniposide; Thioguanine; Vincristine

1990
Prognosis of initial CNS involvement in acute lymphoblastic leukemia childhood.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Brain Neoplasms; Child; Combined Modality Therapy; Germany, East; Germany, West; Gold Radioisotopes; Humans; Life Tables; Meningeal Neoplasms; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiography; Remission Induction; Risk; Spinal Cord Neoplasms; Survival Rate

1990
Central nervous system relapse prevention in 1165 standard-risk children with acute lymphoblastic leukemia in five BFM trials.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; Germany, West; Humans; Injections, Spinal; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Spinal Cord Neoplasms

1990
Risk of CNS relapse after systemic relapse of childhood acute lymphoblastic leukemia.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Female; Germany, West; Humans; Infusions, Intravenous; Injections, Spinal; Life Tables; Male; Methotrexate; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Spinal Cord Neoplasms

1990
Pharmacokinetics of continuous infusion of methotrexate and teniposide in pediatric cancer patients.
    Cancer research, 1990, Jul-15, Volume: 50, Issue:14

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Drug Administration Schedule; Humans; Infusions, Intravenous; Leucovorin; Metabolic Clearance Rate; Methotrexate; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide

1990
Teniposide (VM-26) and continuous infusion cytosine arabinoside for initial induction failure in childhood acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study.
    Cancer, 1990, Oct-15, Volume: 66, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Hydrocortisone; Infant; Infusions, Intravenous; Male; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Teniposide; United States

1990
Interaction between trimethoprim-sulfamethoxazole and methotrexate in children with leukemia.
    The Journal of pediatrics, 1990, Volume: 117, Issue:5

    Topics: Bone Marrow; Child; Child, Preschool; Drug Interactions; Female; Half-Life; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Trimethoprim, Sulfamethoxazole Drug Combination

1990
Biochemical interactions between methotrexate and 1-beta-D-arabinofuranosylcytosine in hematopoietic cells of children: a Pediatric Oncology Group study.
    Cancer chemotherapy and pharmacology, 1990, Volume: 27, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cells, Cultured; Child; Cytarabine; DNA, Neoplasm; Drug Evaluation; Drug Synergism; Hematopoietic Stem Cells; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction

1990
Influence of age, sex, and concurrent intrathecal methotrexate therapy on intellectual function after cranial irradiation during childhood: a report from the Children's Cancer Study Group.
    Pediatric hematology and oncology, 1990, Volume: 7, Issue:4

    Topics: Age Factors; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Injections, Spinal; Intelligence; Male; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors

1990
The prognostic value of testicular biopsy in childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biopsy; Child; Combined Modality Therapy; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Radiotherapy Dosage; Remission Induction; Testicular Neoplasms; Testis; Time Factors; Vincristine

1990
Neurotoxicity in lymphoblastic leukaemia: comparison of oral and intramuscular methotrexate and two doses of radiation.
    Archives of disease in childhood, 1990, Volume: 65, Issue:4

    Topics: Administration, Oral; Brain; Brain Diseases; Calcinosis; Child; Child, Preschool; Combined Modality Therapy; Humans; Infant; Injections, Intramuscular; Injections, Spinal; Intelligence Tests; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Random Allocation; Tomography, X-Ray Computed

1990
Effect of methotrexate on relapse after bone-marrow transplantation for acute lymphoblastic leukaemia. International Bone Marrow Transplant Registry.
    Lancet (London, England), 1989, Mar-11, Volume: 1, Issue:8637

    Topics: Actuarial Analysis; Adolescent; Adult; Bone Marrow Transplantation; Child; Cyclosporins; Drug Evaluation; Graft vs Host Disease; Humans; Methotrexate; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

1989
Three versus five years of maintenance therapy are equivalent in childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biopsy; Child; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Radiotherapy Dosage; Random Allocation; Remission Induction; Sex Factors; Testis; Time Factors; Vincristine

1989
Treatment of childhood acute lymphoblastic leukemia with protocol TCL821: a report of Taiwan Children's Cancer Study Group.
    Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1989, Volume: 88, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Dexamethasone; Doxorubicin; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Hydrocortisone; Infant; Male; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Taiwan; Vincristine

1989
[Treatment of childhood acute lymphoblastic leukemia: randomized trials of protocols CCLSG-L 841 and I 841. (Phase III study). Children's Cancer and Leukemia Study Group].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1989, Volume: 30, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Female; Humans; Infant; Japan; Male; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Randomized Controlled Trials as Topic; Remission Induction; Risk Factors; Vincristine

1989
Early response to induction therapy as a predictor of disease-free survival and late recurrence of childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Humans; Methotrexate; Multicenter Studies as Topic; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Analysis; Vincristine

1989
Intensive therapy for children with acute lymphoblastic leukaemia and unfavourable presenting features. Early conclusions of study CCG-106 by the Childrens Cancer Study Group.
    Lancet (London, England), 1988, Oct-22, Volume: 2, Issue:8617

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Combinations; Female; Humans; Infant; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy Dosage; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

1988
A comparison of two regimens for high-risk acute lymphocytic leukemia in childhood. A Pediatric Oncology Group Study.
    Cancer, 1989, Jan-01, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Humans; Hydrocortisone; Infant; Infant, Newborn; Infections; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prospective Studies; Random Allocation; Remission Induction; Vincristine

1989
High-dose methotrexate improves clinical outcome in children with acute lymphoblastic leukemia: St. Jude Total Therapy Study X.
    Medical and pediatric oncology, 1988, Volume: 16, Issue:5

    Topics: Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Random Allocation; Teniposide

1988
A prospective randomised trial of cyclosporin versus methotrexate after HLA-identical sibling marrow transplantation for patients with acute leukemia in first remission: analysis 2.5 years after last patient entry.
    Australian and New Zealand journal of medicine, 1988, Volume: 18, Issue:4

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Clinical Trials as Topic; Cyclosporins; Female; Graft Survival; Graft vs Host Disease; Histocompatibility Testing; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Random Allocation; Remission Induction

1988
Isolated central nervous system relapse in acute lymphocytic leukemia (ALL) in children. Experiences of the Swiss Pediatric Oncology Group (SPOG/SAKK) 1976-1986.
    Helvetica paediatrica acta, 1988, Volume: 43, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Female; Humans; Hydrocortisone; Infant; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Switzerland

1988
Randomized multicentric Italian study on two treatment regimens for marrow relapse in childhood acute lymphoblastic leukemia.
    Pediatric hematology and oncology, 1986, Volume: 3, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Combinations; Humans; Italy; Life Tables; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Thioguanine; Vincristine

1986

Other Studies

1094 other study(ies) available for methotrexate and Acute Lymphoid Leukemia

ArticleYear
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
    Journal of medicinal chemistry, 1995, Sep-15, Volume: 38, Issue:19

    Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

1995
[Methotrexate-induced stroke-like syndrome: A pediatric case report].
    Archivos argentinos de pediatria, 2021, Volume: 119, Issue:5

    Topics: Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke

2021
Plasma Distribution of Methotrexate and Its Polyglutamates in Pediatric Acute Lymphoblastic Leukemia: Preliminary Insights.
    European journal of drug metabolism and pharmacokinetics, 2022, Volume: 47, Issue:1

    Topics: Antimetabolites, Antineoplastic; Child; Chromatography, Liquid; Humans; Male; Methotrexate; Plasma; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

2022
Myelopathy associated with intrathecal methotrexate.
    Practical neurology, 2022, Volume: 22, Issue:2

    Topics: Adult; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Subacute Combined Degeneration; Young Adult

2022
Simultaneous determination of folate and methotrexate metabolites in serum by LC-MS/MS during high-dose methotrexate therapy.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021, Dec-01, Volume: 1186

    Topics: Antineoplastic Agents; Chromatography, Liquid; Dose-Response Relationship, Drug; Folic Acid; Humans; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tandem Mass Spectrometry

2021
Intrathecal therapy in acute lymphoblastic leukemia case with spinal deformity.
    Pediatrics international : official journal of the Japan Pediatric Society, 2022, Volume: 64, Issue:1

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
High-dose methotrexate therapy for a child with B-cell precursor acute lymphoblastic leukemia and congenital solitary kidney.
    Pediatric blood & cancer, 2022, Volume: 69, Issue:8

    Topics: Burkitt Lymphoma; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solitary Kidney

2022
Upper gastrointestinal bleeding secondary to toxicity by anthracyclines, cytarabine and methotrexate in a patient with acute lymphoblastic leukemia.
    Revista espanola de enfermedades digestivas, 2022, Volume: 114, Issue:6

    Topics: Acute Disease; Anthracyclines; Cytarabine; Gastrointestinal Hemorrhage; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ulcer

2022
Evaluation of cytogenetic and molecular markers with MTX-mediated toxicity in pediatric acute lymphoblastic leukemia patients.
    Cancer chemotherapy and pharmacology, 2022, Volume: 89, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Cytogenetic Analysis; Drug-Related Side Effects and Adverse Reactions; Genotype; Humans; Infant; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
Hypersensitivity reaction to high-dose methotrexate and methotrexate-induced acral erythema in a child with acute lymphoblastic leukemia.
    International journal of clinical pharmacology and therapeutics, 2022, Volume: 60, Issue:6

    Topics: Antimetabolites, Antineoplastic; Child; Erythema; Humans; Hypersensitivity; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes.
    Haematologica, 2022, 10-01, Volume: 107, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Australia; Central Nervous System; Genome-Wide Association Study; Genotype; Humans; Methotrexate; Phenotype; Posterior Leukoencephalopathy Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Seizures

2022
Analysis of the frequency distribution of five single-nucleotide polymorphisms of the MTRRgene in a Chinese pediatric population with acute lymphoblastic leukemia.
    Pharmacotherapy, 2022, Volume: 42, Issue:6

    Topics: Child; Ferredoxin-NADP Reductase; Gene Frequency; Genotype; Humans; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies

2022
Hypoalbuminemia and not undernutrition predicts high-dose methotrexate-induced nephrotoxicity in children with acute lymphoblastic leukemia in resource-constrained centers.
    Pediatric blood & cancer, 2022, Volume: 69, Issue:9

    Topics: Child; Humans; Hypoalbuminemia; Kidney; Leucovorin; Malnutrition; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2022
Sex-Based Differences in Functional Brain Activity During Working Memory in Survivors of Pediatric Acute Lymphoblastic Leukemia.
    JNCI cancer spectrum, 2022, 03-02, Volume: 6, Issue:2

    Topics: Adolescent; Child; Female; Humans; Male; Memory, Short-Term; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prefrontal Cortex; Survivors

2022
Methotrexate-induced Leukoencephalopathy: A Rare but Life-threatening Toxicity.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2022, Volume: 32, Issue:4

    Topics: Acute Disease; Female; Humans; Leukoencephalopathies; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
High-dose methotrexate-related pneumonitis in a child with acute lymphoblastic leukemia.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2023, Volume: 29, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Child; Female; Humans; Methotrexate; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

2023
Dose-individualization Efficiently Maintains Sufficient Exposure to Methotrexate without Additional Toxicity in High-dose Methotrexate Regimens for Pediatric Acute Lymphoblastic Leukemia.
    Current medical science, 2022, Volume: 42, Issue:4

    Topics: Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2022
Long-term results of the treatment of adolescents and adults with acute lymphoblastic leukemia with a pediatric-inspired regimen delivered on an outpatient basis: A single institution experience.
    Leukemia research, 2022, Volume: 121

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Etoposide; Humans; Mercaptopurine; Methotrexate; Outpatients; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

2022
Methotrexate-Mediated Arachnoiditis in a Child with Acute Lymphoblastic Leukemia
    Turkish journal of haematology : official journal of Turkish Society of Haematology, 2022, 12-01, Volume: 39, Issue:4

    Topics: Arachnoiditis; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
Panobinostat (LBH589) increase survival in adult xenografic model of acute lymphoblastic leukemia with t(4;11) but promotes antagonistic effects in combination with MTX and 6MP.
    Medical oncology (Northwood, London, England), 2022, Sep-29, Volume: 39, Issue:12

    Topics: Adult; Animals; Humans; Mercaptopurine; Methotrexate; Mice; Mice, Inbred NOD; Panobinostat; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
[Clinical characteristics and prognosis of seizures in 75 children with acute lymphoblastic leukemia].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2022, Oct-18, Volume: 54, Issue:5

    Topics: Adolescent; Brain Diseases; Cerebral Hemorrhage; Child; Electroencephalography; Epilepsy; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies

2022
Subacute methotrexate neurotoxicity in patients with oncohematological disease. A report of 3 cases.
    Archivos argentinos de pediatria, 2023, 04-01, Volume: 121, Issue:2

    Topics: Antimetabolites, Antineoplastic; Humans; Lymphoma; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Effects of splicing-regulatory polymorphisms in ABCC2, ABCG2, and ABCB1 on methotrexate exposure in Chinese children with acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2023, Volume: 91, Issue:1

    Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Child; East Asian People; Genotype; Humans; Methotrexate; Multidrug Resistance-Associated Protein 2; Neoplasm Proteins; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance.
    Internal medicine (Tokyo, Japan), 2023, Aug-01, Volume: 62, Issue:15

    Topics: Adult; Brain Diseases; Diffusion Magnetic Resonance Imaging; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2023
Escalated doses of methotrexate and L-asparaginase in critically ill children with a concurrent diagnosis of acute lymphoblastic leukemia and appendicitis.
    Pediatric blood & cancer, 2023, Volume: 70, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Appendicitis; Asparaginase; Child; Critical Illness; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Ethnic-specific predictors of neurotoxicity among patients with pediatric acute lymphoblastic leukemia after high-dose methotrexate.
    Cancer, 2023, 04-15, Volume: 129, Issue:8

    Topics: Antimetabolites, Antineoplastic; Child; Creatinine; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2023
Severe Recurrent Nocturnal Hypoglycemia During Chemotherapy With 6-mercaptopurine in 2 Children With Acute Lymphoblastic Leukemia.
    Journal of pediatric hematology/oncology, 2023, 04-01, Volume: 45, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Child; Female; Humans; Hypoglycemia; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Acute kidney injury and delayed methotrexate clearance in an adult patient with Philadelphia chromosome-positive acute lymphoblastic leukaemia treated with imatinib.
    European journal of hospital pharmacy : science and practice, 2023, Volume: 30, Issue:5

    Topics: Acute Kidney Injury; Adult; Female; Humans; Imatinib Mesylate; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Novel and replicated clinical and genetic risk factors for toxicity from high-dose methotrexate in pediatric acute lymphoblastic leukemia.
    Pharmacotherapy, 2023, Volume: 43, Issue:3

    Topics: Bayes Theorem; Child; Creatinine; Humans; Liver-Specific Organic Anion Transporter 1; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk Factors

2023
[Applicability of Seven Glomerular Filtration Rate Evaluation Formulas in Dose Adjustment of High Concentration of Methotrexate Chemotherapy in Children with ALL].
    Zhongguo shi yan xue ye xue za zhi, 2023, Volume: 31, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Creatinine; Glomerular Filtration Rate; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency, Chronic

2023
Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling.
    Journal of biochemical and molecular toxicology, 2023, Volume: 37, Issue:5

    Topics: Animals; Chemical and Drug Induced Liver Injury; Melatonin; Methotrexate; Phosphatidylinositol 3-Kinases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Rats; TOR Serine-Threonine Kinases

2023
Correlation between methylation level of the
    Pharmacogenomics, 2023, Volume: 24, Issue:5

    Topics: Adult; Antimetabolites, Antineoplastic; Humans; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein; Retrospective Studies

2023
Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia.
    Haematologica, 2023, Dec-01, Volume: 108, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Humans; Induction Chemotherapy; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Impact of triple intrathecal prophylaxis in acute lymphoblastic leukemia adults receiving HyperCVAD: A COVID-19 practice change.
    European journal of haematology, 2023, Volume: 111, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; COVID-19; Cyclophosphamide; Humans; Methotrexate; Pandemics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Vincristine

2023
[Correlation between
    Zhongguo shi yan xue ye xue za zhi, 2023, Volume: 31, Issue:2

    Topics: Child; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Frequency; Genotype; Humans; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transcription Factors

2023
Population Pharmacokinetic Model of Methotrexate in Brazilian Pediatric Patients with Acute Lymphoblastic Leukemia.
    Pharmaceutical research, 2023, Volume: 40, Issue:7

    Topics: Antimetabolites, Antineoplastic; Brazil; Child; Humans; Kinetics; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Management of methotrexate and low-dose acetylsalicylic acid interaction in a child with acute lymphoblastic leukemia and moyamoya disease: A case report.
    Pediatric blood & cancer, 2023, Volume: 70, Issue:10

    Topics: Aspirin; Child; Humans; Methotrexate; Moyamoya Disease; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Metabolomic profiling reveals the mechanisms underlying the nephrotoxicity of methotrexate in children with acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2023, Volume: 70, Issue:10

    Topics: Acute Kidney Injury; Child; Humans; Metabolomics; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Pharmacokinetic-pharmacodynamic modeling of maintenance therapy for childhood acute lymphoblastic leukemia.
    Scientific reports, 2023, 07-20, Volume: 13, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Humans; Leukocyte Count; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org.
    Clinical and translational science, 2023, Volume: 16, Issue:11

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Young Adult

2023
Predicting delayed methotrexate elimination in pediatric acute lymphoblastic leukemia patients: an innovative web-based machine learning tool developed through a multicenter, retrospective analysis.
    BMC medical informatics and decision making, 2023, 08-03, Volume: 23, Issue:1

    Topics: Child; Creatinine; Humans; Internet; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2023
A semimechanistic pharmacokinetic/pharmacodynamic model for alanine aminotransferase-based hepatotoxicity of methotrexate in paediatric patients with acute lymphoid leukaemia.
    British journal of clinical pharmacology, 2023, Volume: 89, Issue:12

    Topics: Alanine Transaminase; Chemical and Drug Induced Liver Injury; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2023
MicroRNA-411-3p motivates methotrexate's cellular uptake and cytotoxicity via targeting Yin-yang 1 in leukemia cells.
    Acta biochimica Polonica, 2023, Sep-19, Volume: 70, Issue:3

    Topics: Biological Transport; Humans; Methotrexate; MicroRNAs; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Yin-Yang

2023
The Expression and Activation of the NF-κB Pathway Correlate with Methotrexate Resistance and Cell Proliferation in Acute Lymphoblastic Leukemia.
    Genes, 2023, 09-27, Volume: 14, Issue:10

    Topics: Cell Proliferation; Child; Humans; Immunosuppressive Agents; Methotrexate; NF-kappa B; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Necrosis Factor-alpha

2023
[Characteristics and management of leukoencephalopathy in leukemia treatment].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2023, Volume: 64, Issue:9

    Topics: Administration, Intravenous; Central Nervous System; Humans; Leukoencephalopathies; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2023
Invasive mucormycosis during treatment for acute lymphoblastic leukaemia-successful management of two life-threatening diseases.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020, Volume: 28, Issue:5

    Topics: Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Invasive Fungal Infections; Lung Diseases, Fungal; Male; Mercaptopurine; Methotrexate; Mucorales; Mucormycosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Triazoles; Vincristine

2020
Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia.
    PloS one, 2019, Volume: 14, Issue:9

    Topics: Adolescent; Antidotes; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Infant; Leucovorin; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12

2019
Methotrexate and asparaginase: not so simple.
    Leukemia & lymphoma, 2019, Volume: 60, Issue:12

    Topics: Asparaginase; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2019
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 01-01, Volume: 26, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Child; Child, Preschool; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Transcription Factors; Treatment Outcome; Tumor Cells, Cultured

2020
Serum neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for predicting high dose methotrexate associated acute kidney injury in children with acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2020, Volume: 85, Issue:1

    Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Biomarkers; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Infant; Lipocalin-2; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; ROC Curve

2020
Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia.
    Blood, 2020, 01-02, Volume: 135, Issue:1

    Topics: 5'-Nucleotidase; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Child; DNA Mutational Analysis; Female; Follow-Up Studies; Genomics; High-Throughput Nucleotide Sequencing; Humans; Male; Methotrexate; Mutagenesis; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Receptors, Glucocorticoid; Survival Rate; Tumor Suppressor Protein p53

2020
Diffuse large B cell lymphoma associated with methotrexate in a patient with acute lymphoblastic leukemia.
    Medicina clinica, 2020, 11-27, Volume: 155, Issue:10

    Topics: Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line.
    Medicina (Kaunas, Lithuania), 2019, Nov-26, Volume: 55, Issue:12

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Line, Tumor; Glutamic Acid; Humans; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2019
Prediction of leukocyte counts during paediatric acute lymphoblastic leukaemia maintenance therapy.
    Scientific reports, 2019, 12-02, Volume: 9, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Child; Child, Preschool; Datasets as Topic; Drug Dosage Calculations; Female; Humans; Infant; Leukocyte Count; Leukocytes; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Models, Biological; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stochastic Processes

2019
Optimizing the use of the hyperCVAD regimen: Clinical vignettes and practical management.
    Cancer, 2020, 03-15, Volume: 126, Issue:6

    Topics: Age Factors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Constipation; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Monitoring; Fusion Proteins, bcr-abl; Genetic Predisposition to Disease; Humans; Injections, Spinal; Intercellular Signaling Peptides and Proteins; Kidney; Methotrexate; Ophthalmic Solutions; Peripheral Nervous System Diseases; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Protein-Tyrosine Kinases; Vincristine

2020
Systemic methotrexate absorption in a patient receiving intrathecal chemotherapy for acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2020, Volume: 61, Issue:4

    Topics: Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Severe, Fatal Methotrexate-related Neurotoxicity in 2 Adolescent Patients With ALL.
    Journal of pediatric hematology/oncology, 2020, Volume: 42, Issue:8

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Fatal Outcome; Female; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Severity of Illness Index; Young Adult

2020
Pharmacogenetic Variants in MTHFR Gene are Significant Predictors of Methotrexate Toxicities in Bangladeshi Patients With Acute Lymphoblastic Leukemia.
    Clinical lymphoma, myeloma & leukemia, 2020, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Bangladesh; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenomic Variants; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2020
Delayed methotrexate clearance and acute kidney injury after high-dose methotrexate chemotherapy concurrent with dasatinib in a patient with relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia: A case report.
    Pediatric blood & cancer, 2020, Volume: 67, Issue:4

    Topics: Acute Kidney Injury; Dasatinib; Humans; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors

2020
Dextromethorphan Administration on Day 0 and Day 7 for Secondary Prevention of Methotrexate-induced Neurotoxicity in Childhood Acute Lymphoblastic Leukemia: A Retrospective Case Series.
    Journal of pediatric hematology/oncology, 2021, 03-01, Volume: 43, Issue:2

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Secondary Prevention; Young Adult

2021
Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate.
    Arquivos de neuro-psiquiatria, 2020, Volume: 78, Issue:2

    Topics: Auditory Pathways; Auditory Threshold; Brain Stem; Child; Child, Preschool; Evoked Potentials, Auditory, Brain Stem; Humans; Methotrexate; Otoacoustic Emissions, Spontaneous; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Reduced-dose intensity therapy for pediatric lymphoblastic leukemia: long-term results of the Recife RELLA05 pilot study.
    Blood, 2020, 04-23, Volume: 135, Issue:17

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Rate; Vincristine

2020
Genetic polymorphism in
    International journal of clinical pharmacology and therapeutics, 2020, Volume: 58, Issue:5

    Topics: Antimetabolites, Antineoplastic; Asian People; ATP Binding Cassette Transporter, Subfamily B; Child; China; Female; Gene Frequency; Genotype; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia.
    Annals of hematology, 2020, Volume: 99, Issue:4

    Topics: Abnormal Karyotype; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Comparative Genomic Hybridization; Cyclophosphamide; Cytarabine; Daunorubicin; Genes, Neoplasm; Humans; Ikaros Transcription Factor; In Situ Hybridization, Fluorescence; Mercaptopurine; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Risk Factors; RNA, Messenger; RNA, Neoplasm; Sequence Analysis, RNA; Transcriptome; Vincristine; Workflow

2020
Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicity.
    Cancer medicine, 2020, Volume: 9, Issue:10

    Topics: Acetylcysteine; Bone Marrow; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Deferasirox; Drug Resistance, Neoplasm; Female; Ferric Compounds; Free Radical Scavengers; Humans; Infant; Inhibitory Concentration 50; Iron; Iron Chelating Agents; Male; Methotrexate; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-bcl-2; Quaternary Ammonium Compounds; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Transcriptome; Up-Regulation

2020
Isolated Central Nervous System Relapse Following Treatment Reduction in Low-risk Acute Lymphoblastic Leukemia at the Children's Cancer Center of Lebanon.
    Journal of pediatric hematology/oncology, 2020, Volume: 42, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Central Nervous System Neoplasms; Child; Child, Preschool; Dexamethasone; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Incidence; Infant; Lebanon; Male; Methotrexate; Neoplasm Recurrence, Local; Non-Randomized Controlled Trials as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Survival Rate

2020
T Regulatory Cell Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia.
    Iranian journal of immunology : IJI, 2020, Volume: 17, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Etoposide; Female; Humans; Hydrocortisone; Maintenance Chemotherapy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; T-Lymphocytes, Regulatory; Vincristine

2020
Pharmacogenomic Markers of Methotrexate Response in the Consolidation Phase of Pediatric Acute Lymphoblastic Leukemia Treatment.
    Genes, 2020, 04-24, Volume: 11, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Gene Expression Regulation, Neoplastic; Genotype; Humans; Infant; Male; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia.
    Blood, 2020, 09-03, Volume: 136, Issue:10

    Topics: Adolescent; Adult; Child; Child, Preschool; Female; Genome-Wide Association Study; Humans; Infant; Infant, Newborn; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Peptide Synthases; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Tetrahydrofolate Dehydrogenase; Young Adult

2020
Concurrent Imatinib Dosing With High-dose Methotrexate Leads to Acute Kidney Injury and Delayed Methotrexate Clearance in Pediatric Patients With Philadelphia Chromosome-positive B-Cell Acute Lymphoblastic Leukemia.
    Journal of pediatric hematology/oncology, 2021, 03-01, Volume: 43, Issue:2

    Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Imatinib Mesylate; Leukemia, B-Cell; Male; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Young Adult

2021
Methylation analysis of the SLC19A1 promoter region in Chinese children with acute lymphoblastic leukaemia.
    Journal of clinical pharmacy and therapeutics, 2020, Volume: 45, Issue:4

    Topics: Antimetabolites, Antineoplastic; Asian People; Child; Female; Humans; Male; Methotrexate; Methylation; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein

2020
High-dose methotrexate-induced fulminant hepatic failure and pancytopenia in an acute lymphoblastic leukaemia paediatric patient.
    European journal of hospital pharmacy : science and practice, 2020, Volume: 27, Issue:3

    Topics: Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child, Preschool; Dose-Response Relationship, Drug; Fatal Outcome; Heart Arrest; Humans; Liver Failure, Acute; Male; Methotrexate; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia.
    PloS one, 2020, Volume: 15, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Child; Humans; In Vitro Techniques; Leucovorin; Methotrexate; Mouth Mucosa; Organ Culture Techniques; Organoids; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis

2020
Influence of plasma methotrexate level and MTHFR genotype in Korean paediatric patients with acute lymphoblastic leukaemia.
    Journal of chemotherapy (Florence, Italy), 2020, Volume: 32, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Republic of Korea

2020
Association of GGH Promoter Methylation Levels with Methotrexate Concentrations in Chinese Children with Acute Lymphoblastic Leukemia.
    Pharmacotherapy, 2020, Volume: 40, Issue:7

    Topics: Antimetabolites, Antineoplastic; Asian People; Child; Child, Preschool; China; DNA Methylation; Female; gamma-Glutamyl Hydrolase; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Assessing changes in microstructural integrity of white matter tracts in children with leukaemia following exposure to chemotherapy.
    Pediatric radiology, 2020, Volume: 50, Issue:9

    Topics: Anisotropy; Antimetabolites, Antineoplastic; Brain Mapping; Child; Child, Preschool; Diffusion Tensor Imaging; Female; Humans; Image Interpretation, Computer-Assisted; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; White Matter

2020
Hispanic ethnicity is associated with prolonged clearance of high dose methotrexate and severe nephrotoxicity in children and adolescents with acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2020, Volume: 61, Issue:11

    Topics: Adolescent; Child; Ethnicity; Hispanic or Latino; Humans; Infant; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency

2020
Do intravenous fluid substitutions influence methotrexate clearance? An unanticipated impact of an intravenous sodium bicarbonate drug shortage.
    Pediatric blood & cancer, 2020, Volume: 67, Issue:9

    Topics: Administration, Intravenous; Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Sodium; Sodium Bicarbonate

2020
Interleukin-6-Mediated Inflammation May Cause Methotrexate-Induced Leukoencephalopathy.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2020, Volume: 40, Issue:7

    Topics: Antimetabolites, Antineoplastic; Child; Humans; Hypertension; Inflammation; Interleukin-6; Leukoencephalopathies; Methotrexate; Posterior Leukoencephalopathy Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy.
    Leukemia, 2021, Volume: 35, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Child; Child, Preschool; Down Syndrome; Female; Follow-Up Studies; Humans; Infant; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Rate

2021
Drug-induced aseptic meningitis in a Ph+ ALL patient with meningeal involvement.
    Blood, 2020, 07-23, Volume: 136, Issue:4

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Meningitis, Aseptic; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
A second administration of glucarpidase in a different cycle of high-dose methotrexate: Is it safe and effective in adults?
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:3

    Topics: Acute Kidney Injury; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; gamma-Glutamyl Hydrolase; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Treatment Outcome

2021
SARS-CoV-2 infection in a 7-year-old girl with pancytopenia during acute lymphocytic leukemia maintenance therapy.
    Pediatric blood & cancer, 2020, Volume: 67, Issue:11

    Topics: Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antiviral Agents; Austria; Child; COVID-19; COVID-19 Drug Treatment; Female; Humans; Mercaptopurine; Methotrexate; Pancytopenia; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; SARS-CoV-2; Treatment Outcome

2020
Safe administration of high-dose methotrexate with minimal drug level monitoring: Experience from a center in north India.
    Pediatric blood & cancer, 2020, Volume: 67, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Female; Follow-Up Studies; Humans; India; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Survival Rate

2020
Oral mucositis in childhood cancer patients receiving high-dose methotrexate: Prevalence, relationship with other toxicities and methotrexate elimination.
    International journal of paediatric dentistry, 2021, Volume: 31, Issue:2

    Topics: Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Stomatitis

2021
Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:6

    Topics: Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2021
Body Surface Area Dosing of High-Dose Methotrexate Should Be Reconsidered, Particularly in Overweight, Adult Patients.
    Therapeutic drug monitoring, 2021, 06-01, Volume: 43, Issue:3

    Topics: Acute Kidney Injury; Adult; Antimetabolites, Antineoplastic; Body Surface Area; Humans; Methotrexate; Overweight; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2021
Effect of SLCO1B1 Polymorphisms on High-Dose Methotrexate Clearance in Children and Young Adults With Leukemia and Lymphoblastic Lymphoma.
    Clinical and translational science, 2021, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Leukemia, Lymphoid; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Models, Biological; Pharmacogenomic Testing; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2021
Repeat-positive SARS-CoV-2 in a child with cancer.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:3

    Topics: Antimetabolites, Antineoplastic; Asymptomatic Diseases; Child, Preschool; COVID-19; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; SARS-CoV-2

2021
An exploration of mercaptopurine/methotrexate tolerance during maintenance therapy in children with acute lymphoblastic leukemia.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2021
Cyclin D1 G870A Polymorphism: Relation to the Risk of ALL Development, Prognosis Impact, and Methotrexate Cytotoxicity.
    Asian Pacific journal of cancer prevention : APJCP, 2020, Oct-01, Volume: 21, Issue:10

    Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Cyclin D1; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Infant; Liver Function Tests; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Rate

2020
Citrulline as a biomarker of bacteraemia during induction treatment for childhood acute lymphoblastic leukaemia.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Bacteria; Biomarkers; Child; Child, Preschool; Citrulline; Doxorubicin; Female; Follow-Up Studies; Humans; Induction Chemotherapy; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Retrospective Studies; Vincristine

2021
Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo.
    The Journal of clinical investigation, 2020, 12-01, Volume: 130, Issue:12

    Topics: Adolescent; Cell Line, Tumor; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Neoplasm Proteins; Pharmacogenomic Testing; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Comparison of outcomes of children with acute lymphoblastic leukemia treated with BMF protocol across 2 decades.
    Pediatric hematology and oncology, 2021, Volume: 38, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tegafur; Time Factors; Treatment Outcome

2021
Effects of thymidylate synthase polymorphisms on toxicities associated with high-dose methotrexate in childhood acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2021, Volume: 87, Issue:3

    Topics: Adolescent; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Genotype; Humans; Male; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Retrospective Studies; Thymidylate Synthase

2021
Development and Validation of UHPLC-MS/MS Assay for Therapeutic Drug Monitoring of High-dose Methotrexate in Children with Acute Lymphoblastic Leukemia.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: Adolescent; Antimetabolites, Antineoplastic; Calibration; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Methotrexate; Molecular Structure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality Assurance, Health Care; Tandem Mass Spectrometry

2020
Standardized Supportive Care Documentation Improves Safety of High-Dose Methotrexate Treatment.
    The oncologist, 2021, Volume: 26, Issue:2

    Topics: Bone Neoplasms; Documentation; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2021
Connectivity of the Cerebello-Thalamo-Cortical Pathway in Survivors of Childhood Leukemia Treated With Chemotherapy Only.
    JAMA network open, 2020, 11-02, Volume: 3, Issue:11

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cancer Survivors; Case-Control Studies; Cerebellum; Cerebral Cortex; Chemotherapy-Related Cognitive Impairment; Child; Dexamethasone; Executive Function; Female; Functional Neuroimaging; Glucocorticoids; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Methotrexate; Neural Pathways; Neuropsychological Tests; Organ Size; Parietal Lobe; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prefrontal Cortex; Sex Factors; Thalamus; Young Adult

2020
The Application of
    BioMed research international, 2020, Volume: 2020

    Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Child; Child, Preschool; China; Female; Glomerular Filtration Rate; Humans; Induction Chemotherapy; Kidney Function Tests; Logistic Models; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; ROC Curve; Technetium Tc 99m Pentetate

2020
Delayed Methotrexate Elimination after Administration of a Medium Dose of Methotrexate in a Patient with Genetic Variants Associated with Methotrexate Clearance.
    Acta medica Okayama, 2020, Volume: 74, Issue:6

    Topics: Antimetabolites, Antineoplastic; Child; Humans; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Genetic factors involved in delayed methotrexate elimination in children with acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2021
Methotrexate-induced Transient Encephalopathy in an Adolescent and Young Adult Patient with Acute Lymphoblastic Leukemia.
    Internal medicine (Tokyo, Japan), 2021, Jul-01, Volume: 60, Issue:13

    Topics: Adolescent; Brain Diseases; Diffusion Magnetic Resonance Imaging; Female; Humans; Methotrexate; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2021
Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia.
    Haematologica, 2022, 03-01, Volume: 107, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Australia; Child; Genome-Wide Association Study; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

2022
UK paediatric oncology
    Archives of disease in childhood, 2021, Volume: 106, Issue:10

    Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antimetabolites, Antineoplastic; Child; Child, Preschool; Humans; Incidence; Infant; Ireland; Methotrexate; Neoplasms; Pneumocystis carinii; Pneumonia, Pneumocystis; Population Surveillance; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Trimethoprim, Sulfamethoxazole Drug Combination; United Kingdom

2021
New Therapeutic Approach to Reduce Methotrexate Toxicity after High-Dose Chemotherapy in a Child with Acute Lymphocytic Leukemia: Efficacy and Safety of Hemoadsorption with HA-230 Adsorber.
    Blood purification, 2022, Volume: 51, Issue:1

    Topics: Antimetabolites, Antineoplastic; Child; Hemoperfusion; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
High-dose methotrexate-induced epidermal necrosis in two pediatric patients.
    Pediatric dermatology, 2021, Volume: 38, Issue:3

    Topics: Child; Child, Preschool; Female; Humans; Leucovorin; Male; Methotrexate; Necrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Diseases

2021
Safety and Efficacy of Aminophylline in Intrathecal Methotrexate-related Neurological Toxicity in Large Pediatric Oncology Centre.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2021, Volume: 30, Issue:4

    Topics: Aminophylline; Child; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2021
Acute myelopathy during chemotherapy for childhood acute lymphoblastic leukemia.
    Pediatrics international : official journal of the Japan Pediatric Society, 2021, Volume: 63, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases

2021
Machine learning to predict high-dose methotrexate-related neutropenia and fever in children with B-cell acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2021, Volume: 62, Issue:10

    Topics: Artificial Intelligence; B-Lymphocytes; Child; Humans; Machine Learning; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2021
The Effect of a New Glucose-Methotrexate Conjugate on Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma Cell Lines.
    Molecules (Basel, Switzerland), 2021, Apr-27, Volume: 26, Issue:9

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Glucose; Glucose Transport Proteins, Facilitative; Humans; Immunoconjugates; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2021
No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
    Cancer chemotherapy and pharmacology, 2021, Volume: 88, Issue:2

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; DNA; Female; Genotype; Humans; Infant; Male; Mercaptopurine; Methotrexate; Methyltransferases; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2021
Methylene tetrahydrofolate reductase A1298C polymorphisms influence the adult sequelae of chemotherapy in childhood-leukemia survivors.
    PloS one, 2021, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Brain; Cancer Survivors; Child; Child, Preschool; Cognition; Diffusion Magnetic Resonance Imaging; Disease Progression; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid Antagonists; Genotype; Humans; Intelligence Tests; Magnetic Resonance Imaging; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rest; Retrospective Studies; tau Proteins; Young Adult

2021
Methotrexate polyglutamate quantification for clinical application in patients with pediatric acute lymphoblastic leukemia in association with genetic polymorphisms.
    Journal of pharmaceutical and biomedical analysis, 2021, Jul-15, Volume: 201

    Topics: Child; Humans; Methotrexate; Polyglutamic Acid; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2021
MTHFR 677T-1298C haplotype in acute lymphoblastic leukemia: Impact on methotrexate therapy.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:5

    Topics: Genotype; Haplotypes; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
Phase-specific risks of outpatient visits, emergency visits, and hospitalizations during Children's Oncology Group-based treatment for childhood acute lymphoblastic leukemia: A population-based study.
    Pediatric blood & cancer, 2021, Volume: 68, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Dexamethasone; Emergency Service, Hospital; Hospitalization; Humans; Methotrexate; Ontario; Outpatients; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone

2021
Reduced dose folinic acid rescue after rapid high-dose methotrexate clearance is not associated with increased toxicity in a pediatric cohort.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022, Volume: 30, Issue:1

    Topics: Acute Disease; Child; Cohort Studies; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2022
Severe multiorgan toxicity after first dose of Capizzi methotrexate in a young adult patient with acute lymphocytic leukaemia.
    BMJ case reports, 2021, Jul-08, Volume: 14, Issue:7

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2021
Monitoring Of High-Dose Methotrexate (Mtx)-Related Toxicity and Mtx Levels in Children with Acute Lymphoblastic Leukemia: A Pilot-Study in Indonesia.
    Asian Pacific journal of cancer prevention : APJCP, 2021, Jul-01, Volume: 22, Issue:7

    Topics: Antimetabolites, Antineoplastic; Child; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Indonesia; Infusions, Intravenous; Male; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

2021
Association of MTHFR and ABCB1 polymorphisms with MTX-induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma-A retrospective cohort study.
    Journal of clinical pharmacy and therapeutics, 2021, Volume: 46, Issue:6

    Topics: Adolescent; Asian People; ATP Binding Cassette Transporter, Subfamily B; Child; Child, Preschool; China; Female; Genotype; Humans; Infant; Lymphoma; Lymphoproliferative Disorders; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Osteosarcoma; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2021
[A case of acute lymphoblastic leukemia of MTHFR C677T gene positive with methotrexate hypersensitivity was successfully rescued by hemodialysis].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2021, Jun-14, Volume: 42, Issue:6

    Topics: Antimetabolites, Antineoplastic; Genetic Predisposition to Disease; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Dialysis

2021
Efficacy of chemotherapy protocols for hematological malignancies: H-CVAD versus GELA/BURKIMAB/PETHEMA LAL.
    Experimental hematology, 2021, Volume: 101-102

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Burkitt Lymphoma; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Hematologic Neoplasms; Humans; Lymphoma, Mantle-Cell; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Treatment Outcome; Vincristine; Young Adult

2021
Childhood pre-B cell acute lymphoblastic leukemia with translocation t(1;19)(q21.1;p13.3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report.
    Journal of medical case reports, 2017, Apr-07, Volume: 11, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Chromosome Aberrations; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 16; Doxorubicin; Fatal Outcome; Health Services Accessibility; Humans; Immunophenotyping; Male; Methotrexate; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Syria; Translocation, Genetic; Vincristine

2017
Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients.
    Archives of medical research, 2016, Volume: 47, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Female; Gene Frequency; Genotype; Heterozygote; Homozygote; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Mexico; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2016
Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia.
    Oncotarget, 2017, Jun-06, Volume: 8, Issue:23

    Topics: Female; Genotype; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2017
Prognostic impact of IKZF1 deletions in association with vincristine-dexamethasone pulses during maintenance treatment of childhood acute lymphoblastic leukemia on trial ALL-BFM 95.
    Leukemia, 2017, Volume: 31, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Gene Deletion; Humans; Ikaros Transcription Factor; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome; Vincristine

2017
Nausea and vomiting: Therapeutic orphans of pediatric oncology.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:10

    Topics: Antiemetics; Child; Child, Preschool; Granisetron; Humans; Methotrexate; Nausea; Ondansetron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serotonin 5-HT3 Receptor Antagonists; Vomiting

2017
Effectiveness of Parenteral Glutamine on Methotrexate-induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia.
    Nutrition and cancer, 2017, Volume: 69, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Glutamine; Humans; Male; Methotrexate; Parenteral Nutrition; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Stomatitis

2017
The miR-1206 microRNA variant is associated with methotrexate-induced oral mucositis in pediatric acute lymphoblastic leukemia.
    Pharmacogenetics and genomics, 2017, Volume: 27, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Gene Frequency; Genetic Association Studies; Humans; Infant; Male; Methotrexate; MicroRNAs; Nucleic Acid Conformation; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Stomatitis

2017
[Effect of GSTP1 and MTHFR Gene Polymorphism on Side Effects of HD-MTX in ALL Children].
    Zhongguo shi yan xue ye xue za zhi, 2017, Volume: 25, Issue:3

    Topics: Antimetabolites, Antineoplastic; Child; Gene Frequency; Glutathione S-Transferase pi; Homocystinuria; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2017
Effect of polymorphisms in transporter genes on dosing, efficacy and toxicity of maintenance therapy in children with acute lymphoblastic leukemia.
    Gene, 2017, Sep-10, Volume: 628

    Topics: Adolescent; Antimetabolites, Antineoplastic; ATP-Binding Cassette Transporters; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Multidrug Resistance-Associated Protein 2; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2017
Faecal microbiota transplant: a novel biological approach to extensively drug-resistant organism-related non-relapse mortality.
    Bone marrow transplantation, 2017, Volume: 52, Issue:10

    Topics: Allografts; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacteria; Daunorubicin; Drug Resistance, Bacterial; Fatal Outcome; Fecal Microbiota Transplantation; Feces; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine

2017
Dihydrofolate Reductase Genetic Polymorphisms Affect Methotrexate Dose Requirements in Pediatric Patients With Acute Lymphoblastic Leukemia on Maintenance Therapy.
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:8

    Topics: Alleles; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Genotype; Haplotypes; Humans; Infant; Infant, Newborn; Maintenance Chemotherapy; Male; Methotrexate; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Tetrahydrofolate Dehydrogenase

2017
Targeted therapy of CNS leukemia?
    Blood, 2017, 08-03, Volume: 130, Issue:5

    Topics: Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2017
Effect of methotrexate/vitamin B
    Epigenomics, 2017, Volume: 9, Issue:9

    Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Methylation; Humans; Long Interspersed Nucleotide Elements; Methotrexate; Neurons; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tacrolimus Binding Proteins; Vitamin B 12

2017
Posterior reversible encephalopathy syndrome in a postpartum woman with acute lymphoblastic leukaemia after intrathecal methotrexate.
    BMJ case reports, 2017, Oct-04, Volume: 2017

    Topics: Antimetabolites, Antineoplastic; Diagnosis, Differential; Female; Humans; Induction Chemotherapy; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Posterior Leukoencephalopathy Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications, Neoplastic; Young Adult

2017
Evaluation of aprepitant for acute chemotherapy-induced nausea and vomiting in children and adolescents with acute lymphoblastic leukemia receiving high-dose methotrexate.
    Pediatric blood & cancer, 2018, Volume: 65, Issue:2

    Topics: Adolescent; Antiemetics; Aprepitant; Child; Female; Humans; Male; Methotrexate; Morpholines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Vomiting

2018
Neurocognitive Functioning in the AALL0232 Protocol.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, 12-10, Volume: 35, Issue:35

    Topics: Adrenal Cortex Hormones; Child; Cognition Disorders; Humans; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2017
[Acute methotrexate-related neurotoxicity and pseudo-stroke syndrome].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2017, Volume: 24, Issue:12

    Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Child; Diagnosis, Differential; Female; Humans; Leukoencephalopathies; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; Syndrome

2017
DNA variants in DHFR gene and response to treatment in children with childhood B ALL: revisited in AIEOP-BFM protocol.
    Pharmacogenomics, 2018, Volume: 19, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers, Tumor; Child; Daunorubicin; Disease-Free Survival; DNA; Female; Haplotypes; Humans; Male; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Promoter Regions, Genetic; Tetrahydrofolate Dehydrogenase; Treatment Outcome; Vincristine

2018
A Not Uncommon Cause of Stroke Mimicker in Children.
    Pediatric neurology, 2018, Volume: 80

    Topics: Adolescent; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke

2018
Changes in cognition and dendritic complexity following intrathecal methotrexate and cytarabine treatment in a juvenile murine model.
    Behavioural brain research, 2018, 07-02, Volume: 346

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cognition; Cytarabine; Dendrites; Hippocampus; Injections, Spinal; Leukocytes; Male; Methotrexate; Mice, Inbred C57BL; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spatial Memory

2018
Flow cytometric analysis of cerebrospinal fluid in adult patients with acute lymphoblastic leukemia during follow-up.
    European journal of haematology, 2018, Volume: 100, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cytarabine; Dexamethasone; Female; Flow Cytometry; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Analysis; Transplantation, Homologous; Whole-Body Irradiation

2018
Risk factors for impaired pulmonary function and cardiorespiratory fitness in very long-term adult survivors of childhood acute lymphoblastic leukemia after treatment with chemotherapy only
    Acta oncologica (Stockholm, Sweden), 2018, Volume: 57, Issue:5

    Topics: Adolescent; Adult; Anthracyclines; Antineoplastic Agents; Cardiorespiratory Fitness; Child; Child, Preschool; Cross-Sectional Studies; Cyclophosphamide; Echocardiography; Exercise Test; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Respiratory Function Tests; Respiratory Physiological Phenomena; Risk Factors; Survivors; Vincristine; Young Adult

2018
Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia.
    Leukemia research, 2018, Volume: 65

    Topics: 3' Untranslated Regions; Adolescent; Alleles; Antimetabolites, Antineoplastic; Asian People; Binding Sites; Child; Child, Preschool; China; Female; Fluorescence Polarization Immunoassay; Humans; Male; Methotrexate; MicroRNAs; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Serum Albumin, Human

2018
Acute and sub-acute neurological toxicity in children treated for acute lymphoblastic leukemia.
    Leukemia research, 2018, Volume: 65

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Female; Humans; Infant; Leukoencephalopathies; Male; Methotrexate; Neurotoxicity Syndromes; Polyneuropathies; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Sinus Thrombosis, Intracranial; Treatment Outcome; Vincristine; Vocal Cord Paralysis

2018
MiR-595 Suppresses the Cellular Uptake and Cytotoxic Effects of Methotrexate by Targeting SLC19A1 in CEM/C1 Cells.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:1

    Topics: 3' Untranslated Regions; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; MicroRNAs; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2018
Anti-leukemic treatment-induced neurotoxicity in long-term survivors of childhood acute lymphoblastic leukemia: impact of reduced central nervous system radiotherapy and intermediate- to high-dose methotrexate.
    Leukemia & lymphoma, 2018, Volume: 59, Issue:10

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Brain; Cancer Survivors; Case-Control Studies; Chemoradiotherapy; Child; Cognition Disorders; Cranial Irradiation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Humans; Intelligence Tests; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Organ Size; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Treatment Outcome; Young Adult

2018
Genotype and allele frequencies of TYMS rs2790 A > G polymorphism in a Chinese paediatric population with acute lymphoblastic leukaemia.
    Journal of clinical pharmacy and therapeutics, 2018, Volume: 43, Issue:4

    Topics: Asian People; Child; Female; Gene Frequency; Genotype; Humans; Male; Methotrexate; MicroRNAs; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase

2018
T-cell-replete haploidentical stem cell transplantation using low-dose antithymocyte globulin in children with relapsed or refractory acute leukemia.
    International journal of hematology, 2018, Volume: 108, Issue:1

    Topics: Adolescent; Antilymphocyte Serum; Child; Child, Preschool; Female; Follow-Up Studies; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Retrospective Studies; Survival Rate; Tacrolimus; Transplantation Conditioning; Treatment Outcome; Young Adult

2018
Evidence of cognitive flexibility deficits and impaired emotion regulation in childhood survivors of acute lymphoblastic leukaemia: Findings from task switching study.
    JPMA. The Journal of the Pakistan Medical Association, 2018, Volume: 68, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cancer Survivors; Case-Control Studies; Child; Cognition; Cognitive Dysfunction; Cytarabine; Emotions; Female; Humans; Hydrocortisone; Infusions, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Self-Control; Task Performance and Analysis

2018
Severe immunodeficiency associated with acute lymphoblastic leukemia and its treatment.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2018, Volume: 120, Issue:5

    Topics: Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 4; Exanthema; Female; Humans; Immunoglobulins, Intravenous; Immunologic Deficiency Syndromes; Infant, Newborn; Methotrexate; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Translocation, Genetic; Treatment Outcome

2018
Pharmacoepigenetics in childhood acute lymphoblastic leukemia: involvement of miRNA polymorphisms in hepatotoxicity.
    Epigenomics, 2018, 04-01, Volume: 10, Issue:4

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genetic Association Studies; Humans; Infant; Liver; Male; Methotrexate; MicroRNAs; Nucleic Acid Conformation; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2018
Stevens-Johnson Syndrome associated with methotrexate treatment for acute lymphoblastic leukemia: a case report.
    Archivos argentinos de pediatria, 2018, 06-01, Volume: 116, Issue:3

    Topics: Antimetabolites, Antineoplastic; Child; Gastrointestinal Hemorrhage; Heart Failure; Humans; Immunoglobulins, Intravenous; Male; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stevens-Johnson Syndrome

2018
ALL relapse with multiple cranial nerve palsies and toxic leukoencephalopathy: treatment failure with treatment toxicity.
    BMJ case reports, 2018, Jun-05, Volume: 2018

    Topics: Adult; Cranial Nerve Diseases; Female; Humans; Immunosuppressive Agents; Leukoencephalopathies; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Failure

2018
Neurocognitive Sequelae in Adult Childhood Leukemia Survivors Related to Levels of Phosphorylated Tau.
    Journal of the National Cancer Institute, 2017, 07-01, Volume: 109, Issue:7

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Biomarkers; Case-Control Studies; Cognition Disorders; Cross-Sectional Studies; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neuropsychological Tests; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Survival Rate; Survivors; tau Proteins; Young Adult

2017
Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.
    PloS one, 2018, Volume: 13, Issue:7

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; DNA Methylation; Female; Humans; Immunophenotyping; Infant; Long Interspersed Nucleotide Elements; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Stomatitis

2018
Outcome of adult T-lymphoblastic lymphoma depends on ALL-type chemotherapy, prognostic factors, and performance of allogeneic hematopoietic stem cell transplantation.
    Medicine, 2018, Volume: 97, Issue:28

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Survival Rate; Vincristine; Young Adult

2018
Oral mucositis in paediatric acute lymphoblastic leukemia patients receiving methotrexate-based chemotherapy: case series.
    European journal of paediatric dentistry, 2018, Volume: 19, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis

2018
Paraneoplastic Demyelinating Sensorimotor Neuropathy Delaying the Diagnosis of an Underlying Acute Lymphoblastic Leukemia in a Child.
    Journal of oncology practice, 2018, Volume: 14, Issue:10

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain; Child; Daunorubicin; Demyelinating Diseases; Humans; Immunoglobulins, Intravenous; Magnetic Resonance Imaging; Male; Methotrexate; Paraneoplastic Syndromes, Nervous System; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Spine; Tomography, X-Ray Computed; Vincristine

2018
[Spinal subacute combined degeneration after intrathecal chemotherapy. Report of two cases].
    Revista medica de Chile, 2018, Volume: 146, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Cytarabine; Fatal Outcome; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Subacute Combined Degeneration

2018
Intravitreal Methotrexate for Iris and Ciliary Body Relapse in Acute Lymphoblastic Leukemia.
    Journal of pediatric ophthalmology and strabismus, 2018, Aug-29, Volume: 55

    Topics: Antimetabolites, Antineoplastic; Child; Ciliary Body; Female; Humans; Intravitreal Injections; Iris; Leukemic Infiltration; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Slit Lamp Microscopy

2018
Outcomes of Low-Intensity Treatment of Acute Lymphoblastic Leukemia at Butaro Cancer Center of Excellence in Rwanda.
    Journal of global oncology, 2018, Volume: 4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cancer Care Facilities; Child; Cyclophosphamide; Developing Countries; Dexamethasone; Female; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Rwanda; Treatment Outcome; Vincristine

2018
Comparison between Hyper-CVAD and PETHEMA ALL-93 in Adult Acute Lymphoblastic Leukemia: A Single-Center Study.
    Chemotherapy, 2018, Volume: 63, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Cyclophosphamide; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Fever; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Treatment Outcome; Vincristine; Young Adult

2018
Methotrexate polyglutamate levels and co-distributions in childhood acute lymphoblastic leukemia maintenance therapy.
    Cancer chemotherapy and pharmacology, 2019, Volume: 83, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Erythrocytes; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2019
A mathematical model of white blood cell dynamics during maintenance therapy of childhood acute lymphoblastic leukemia.
    Mathematical medicine and biology : a journal of the IMA, 2019, 12-04, Volume: 36, Issue:4

    Topics: Algorithms; Antimetabolites, Antineoplastic; Child; Drug Therapy, Combination; Humans; Leukocytes; Mercaptopurine; Methotrexate; Models, Theoretical; Outcome Assessment, Health Care; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Secondary Prevention

2019
Renal Function and Plasma Methotrexate Concentrations Predict Toxicities in Adults Receiving High-Dose Methotrexate.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Oct-29, Volume: 24

    Topics: Adult; Asian People; China; Female; Humans; Kidney; Kidney Function Tests; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency; Retrospective Studies

2018
A Cross-sectional Study of Two Chemotherapy Protocols on Long Term Neurocognitive Functions in Egyptian Children Surviving Acute Lymphoblastic Leukemia.
    Current pediatric reviews, 2018, Volume: 14, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cancer Survivors; Child; Child, Preschool; Cognition; Cross-Sectional Studies; Egypt; Female; Humans; Intelligence Tests; Male; Methotrexate; Neurocognitive Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychometrics; Treatment Outcome

2018
Methotrexate induces astrocyte apoptosis by disrupting folate metabolism in the mouse juvenile central nervous system.
    Toxicology letters, 2019, Volume: 301

    Topics: Animals; Apoptosis; Astrocytes; Caspase 3; Cell Line, Tumor; Central Nervous System; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Methotrexate; Mice; Mice, Inbred C57BL; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Tetrahydrofolate Dehydrogenase

2019
Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2019, Volume: 25, Issue:8

    Topics: Adult; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Cytarabine; Humans; Hydrocortisone; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2019
Methotrexate-induced Acute Myelopathy in a Teenager With High-risk Acute Lymphoblastic Leukemia.
    Journal of pediatric hematology/oncology, 2020, Volume: 42, Issue:4

    Topics: Adolescent; Ataxia; Female; Humans; Hypesthesia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Population Pharmacokinetic Study and Individual Dose Adjustments of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia or Osteosarcoma.
    Journal of clinical pharmacology, 2019, Volume: 59, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Asian People; Bone Neoplasms; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Young Adult

2019
Modified enzyme multiplied immunoassay technique of methotrexate assay to improve sensitivity and reduce cost.
    BMC pharmacology & toxicology, 2019, Jan-09, Volume: 20, Issue:1

    Topics: Antimetabolites, Antineoplastic; Child; Chromatography, Liquid; Costs and Cost Analysis; Enzyme Multiplied Immunoassay Technique; Humans; Limit of Detection; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Tandem Mass Spectrometry

2019
Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib.
    Pediatric blood & cancer, 2019, Volume: 66, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dasatinib; Female; Follow-Up Studies; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Tissue Distribution; Young Adult

2019
Folate pathway genetic polymorphisms modulate methotrexate-induced toxicity in childhood acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2019, Volume: 83, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cross-Sectional Studies; Female; Folic Acid; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Retrospective Studies; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2019
Neurotoxicity more likely in Hispanic children treated for acute lymphoblastic leukemia.
    Cancer, 2019, 02-15, Volume: 125, Issue:4

    Topics: Antimetabolites, Antineoplastic; Hispanic or Latino; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2019
The Population Pharmacokinetics of High-Dose Methotrexate in Infants with Acute Lymphoblastic Leukemia Highlight the Need for Bedside Individualized Dose Adjustment: A Report from the Children's Oncology Group.
    Clinical pharmacokinetics, 2019, Volume: 58, Issue:7

    Topics: Antimetabolites, Antineoplastic; Female; Humans; Infant; Male; Methotrexate; Models, Biological; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2019
Ex vivo resistance in childhood acute lymphoblastic leukemia: Correlations between BCRP, MRP1, MRP4 and MRP5 ABC transporter expression and intracellular methotrexate polyglutamate accumulation.
    Leukemia research, 2019, Volume: 79

    Topics: Adolescent; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Child; Child, Preschool; Cytoplasm; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Leukemic; Humans; Infant; Infant, Newborn; Male; Methotrexate; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pilot Projects; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Cell Culture; Tumor Cells, Cultured

2019
Intrathecal dose intensification by CNS status at diagnosis in the treatment of children with acute lymphoblastic leukemia.
    Hematology (Amsterdam, Netherlands), 2019, Volume: 24, Issue:1

    Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate

2019
Visualization of Vertebral Body Deformities in Childhood by MRI in a Boy with ALL.
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2019, Volume: 191, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Density; Bone Marrow; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Fractures, Compression; Humans; Image Enhancement; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Spinal Fractures; Spine; Vincristine

2019
Case report on hypersensitivity to methotrexate infusion in a pediatric acute lymphoblastic leukaemia patient.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2020, Volume: 26, Issue:2

    Topics: Antimetabolites, Antineoplastic; Child; Drug Hypersensitivity; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2020
Development and Validation of a Sensitive UHPLC-MS/MS-Based Method for the Analysis of Folylpolyglutamate Synthetase Enzymatic Activity in Peripheral Blood Mononuclear Cells: Application in Rheumatoid Arthritis and Leukemia Patients.
    Therapeutic drug monitoring, 2019, Volume: 41, Issue:5

    Topics: Arthritis, Rheumatoid; Cell Line, Tumor; Chromatography, High Pressure Liquid; Humans; Leukocytes, Mononuclear; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

2019
Childhood acute lymphoblastic leukaemia relapse with atypical localised presentation mimicking ankle trauma in a 28-year-old man.
    BMJ case reports, 2019, May-21, Volume: 12, Issue:5

    Topics: Adult; Ankle; Diagnosis, Differential; Humans; Leucovorin; Male; Methotrexate; Neoplasm Recurrence, Local; Pain; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed; Vincristine

2019
The effect of asparaginase therapy on methotrexate toxicity and efficacy in children with acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2019, Volume: 60, Issue:12

    Topics: Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2019
British OsteoNEcrosis Study (BONES) protocol: a prospective cohort study to examine the natural history of osteonecrosis in older children, teenagers and young adults with acute lymphoblastic leukaemia and lymphoblastic lymphoma.
    BMJ open, 2019, 05-22, Volume: 9, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Cohort Studies; Dexamethasone; Female; Glucocorticoids; Humans; Lower Extremity; Magnetic Resonance Imaging; Male; Methotrexate; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; United Kingdom; Vincristine; Young Adult

2019
Spinal Cord Toxicity from Intrathecal Chemotherapy: A Case with Clinicopathologic Correlation.
    World neurosurgery, 2019, Volume: 128

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dendritic Cells; Electrodiagnosis; Evoked Potentials, Somatosensory; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Spinal Cord Neoplasms; Treatment Outcome

2019
Influence of genetic factors on long-term treatment related neurocognitive complications, and on anxiety and depression in survivors of childhood acute lymphoblastic leukemia: The Petale study.
    PloS one, 2019, Volume: 14, Issue:6

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Antimetabolites, Antineoplastic; Anxiety; Calcium Channels, L-Type; Child; Child, Preschool; Cohort Studies; Depression; Female; Humans; Infant; Liver-Specific Organic Anion Transporter 1; Long-Term Care; Male; Methotrexate; Neurocognitive Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors; Young Adult

2019
Inotuzumab ozogamicin, a nonchemotherapy option for relapsed acute lymphoblastic leukemia.
    Clinical advances in hematology & oncology : H&O, 2019, Volume: 17, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Bispecific; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Cyclophosphamide; Cytarabine; Dexamethasone; Humans; Inotuzumab Ozogamicin; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Salvage Therapy; Vascular Diseases

2019
Ginger extract has anti-leukemia and anti-drug resistant effects on malignant cells.
    Journal of cancer research and clinical oncology, 2019, Volume: 145, Issue:8

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cinnamomum zeylanicum; Combined Modality Therapy; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Male; Methotrexate; Phytotherapy; Plant Extracts; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tea; Tumor Cells, Cultured; Young Adult; Zingiber officinale

2019
Impact of Childhood Leukemia Treatment on Attention Measured by the Continuous Performance Test Factor Structure.
    Oncology nursing forum, 2019, 07-01, Volume: 46, Issue:4

    Topics: Adolescent; Arizona; Attention; Child; Female; Humans; Longitudinal Studies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Survivors; Texas

2019
Population pharmacokinetic study of delayed methotrexate excretion in children with acute lymphoblastic leukemia
.
    International journal of clinical pharmacology and therapeutics, 2019, Volume: 57, Issue:8

    Topics: Alanine Transaminase; Alkaline Phosphatase; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Bilirubin; Child; Creatinine; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2019
Methotrexate Polyglutamate Values in Children and Adolescents With Acute Lymphoblastic Leukemia During Maintenance Therapy.
    Journal of pediatric hematology/oncology, 2019, Volume: 41, Issue:6

    Topics: Adolescent; Adult; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Maintenance Chemotherapy; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Young Adult

2019
Simultaneous Inhibition of Protein Kinase CK2 and Dihydrofolate Reductase Results in Synergistic Effect on Acute Lymphoblastic Leukemia Cells.
    Anticancer research, 2019, Volume: 39, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Casein Kinase II; Cell Line, Tumor; Drug Synergism; Folic Acid Antagonists; Humans; Methotrexate; Naphthyridines; Phenazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Tetrahydrofolate Dehydrogenase

2019
Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children.
    PloS one, 2019, Volume: 14, Issue:7

    Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Parents; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2019
Long-term outcomes of modified BFM-95 regimen in adults with newly diagnosed standard-risk acute lymphoblastic leukemia: a retrospective single-center study.
    International journal of hematology, 2019, Volume: 110, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asian People; Asparaginase; Cohort Studies; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Retrospective Studies; Risk; Time Factors; Treatment Outcome; Vincristine

2019
Improved Outcome of a Pediatric-Inspired Protocol for High-Risk Adolescent and Young Adult Acute Lymphoblastic Leukemia Patients Using Peg-Asparaginase and Escalating Dose of Methotrexate: Tolerability and Outcome.
    Clinical lymphoma, myeloma & leukemia, 2019, Volume: 19, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Disease-Free Survival; Dose-Response Relationship, Drug; Febrile Neutropenia; Female; Humans; Hyperbilirubinemia; Male; Methotrexate; Outcome Assessment, Health Care; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors; Young Adult

2019
Nasolacrimal system obstruction, ptosis and esotropia due to chemotherapy in acute lymphoblastic leukemia.
    Cutaneous and ocular toxicology, 2013, Volume: 32, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blepharoptosis; Child; Daunorubicin; Esotropia; Female; Humans; Lacrimal Duct Obstruction; Methotrexate; Nasolacrimal Duct; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine

2013
Risk group assignment differs for children and adults 1-45 yr with acute lymphoblastic leukemia treated by the NOPHO ALL-2008 protocol.
    European journal of haematology, 2013, Volume: 90, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytogenetic Analysis; Dexamethasone; Doxorubicin; Drug Administration Schedule; Female; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Infant; Male; Medication Adherence; Methotrexate; Middle Aged; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Registries; Treatment Outcome; Vincristine; Young Adult

2013
[Kaposiform haemangioendothelioma associated with B-cell acute lymphoblastic leukemia].
    Annales de dermatologie et de venereologie, 2013, Volume: 140, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Biopsy; Combined Modality Therapy; Cord Blood Stem Cell Transplantation; Cyclophosphamide; Cytarabine; Diagnostic Errors; Hemangioendothelioma; Hemangioma; Humans; Infant, Newborn; Kasabach-Merritt Syndrome; Leukemia, B-Cell; Male; Mercaptopurine; Methotrexate; Neoplasms, Multiple Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Skin Neoplasms; Transplantation, Homologous

2013
Outcome of patients with acute lymphoblastic leukemia (ALL) following induction therapy with a modified (pulsed dexamethasone rather than continuous prednisone) UKALL XII/ECOG E2993 protocol at Tawam Hospital, United Arab Emirates (UAE).
    Medical oncology (Northwood, London, England), 2013, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cancer Care Facilities; Daunorubicin; Dexamethasone; Female; Humans; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Pulse Therapy, Drug; Retrospective Studies; Treatment Outcome; United Arab Emirates; Vincristine; Young Adult

2013
[Relationship between the methylenetetrahydrofolate reductase gene polymorphism and adverse reactions of high-dose methotrexate in children with acute lymphocytic leukemia].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2013, Volume: 15, Issue:3

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction

2013
Acral erythema worsened by intravenous infusions of cyclosporin.
    Dermatology online journal, 2013, Mar-15, Volume: 19, Issue:3

    Topics: Adult; Antineoplastic Agents; Cyclosporine; Cytarabine; Drug Eruptions; Erythema; Graft vs Host Disease; Humans; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2013
Effects of early chemotherapeutic treatment on learning in adolescent mice: implications for cognitive impairment and remediation in childhood cancer survivors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Jun-01, Volume: 19, Issue:11

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cognitive Dysfunction; Cytarabine; Female; Humans; Learning; Male; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Survivors

2013
[Re-induction therapy of relapsed Ph(+) acute lymphoblastic leukemia with T315I mutation by HA regimen in combination with HD-MTX regimen].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2013, Volume: 34, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Humans; Male; Methotrexate; Middle Aged; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2013
The management of hyperleukocytosis in an adult patient with acute lymphoblastic leukemia and ataxia-telangiectasia.
    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2013, Volume: 48, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Ataxia Telangiectasia; Doxorubicin; Flow Cytometry; Humans; Leucovorin; Leukapheresis; Leukocytosis; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Steroids; Vincristine

2013
Methotrexate-induced myelopathy mimicking subacute combined degeneration of the spinal cord.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013, Volume: 20, Issue:7

    Topics: Adult; Antimetabolites, Antineoplastic; Diagnosis, Differential; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Subacute Combined Degeneration

2013
Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia.
    Blood, 2013, Jun-27, Volume: 121, Issue:26

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Child; Child, Preschool; Cohort Studies; Female; Follow-Up Studies; Germ-Line Mutation; Humans; Infant; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Staging; Neoplasm, Residual; Organic Anion Transporters; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Stomatitis; Survival Rate; Thymidylate Synthase; Tissue Distribution; Treatment Outcome

2013
Can SLC19A1 80G>A polymorphisms predict risk of extremely delayed MTX excretion after high dose of methotrexate?
    Journal of pediatric hematology/oncology, 2013, Volume: 35, Issue:5

    Topics: Child; Genotype; Humans; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2013
Key treatment questions in childhood acute lymphoblastic leukemia: results in 5 consecutive trials performed by the ALL-BFM study group from 1981 to 2000.
    Klinische Padiatrie, 2013, Volume: 225 Suppl 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Europe; Germany; History, 20th Century; History, 21st Century; Humans; Medical Oncology; Mercaptopurine; Methotrexate; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Randomized Controlled Trials as Topic; Vincristine

2013
ALL-REZ BFM--the consecutive trials for children with relapsed acute lymphoblastic leukemia.
    Klinische Padiatrie, 2013, Volume: 225 Suppl 1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Europe; Hematopoietic Stem Cell Transplantation; Humans; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Randomized Controlled Trials as Topic; Recurrence; Remission Induction; Retreatment; Survival Rate; Vincristine

2013
Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis.
    Cell death & disease, 2013, Jun-06, Volume: 4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cyclin B; Cyclin E; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gene Knockdown Techniques; HCT116 Cells; Humans; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2013
Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments.
    Cancer chemotherapy and pharmacology, 2013, Volume: 72, Issue:2

    Topics: Algorithms; Antidotes; Antimetabolites; Dose-Response Relationship, Drug; Drug Delivery Systems; Fluorescence Polarization Immunoassay; Gastrointestinal Diseases; Humans; Injections, Spinal; Leucovorin; Methotrexate; Models, Biological; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2013
Temporal lobe epilepsy with hippocampal sclerosis in acute lymphoblastic leukemia.
    Pediatrics, 2013, Volume: 132, Issue:1

    Topics: Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Diagnosis, Differential; Drug Administration Schedule; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; Female; Follow-Up Studies; Hippocampus; Humans; Image Interpretation, Computer-Assisted; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sclerosis

2013
Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy.
    Blood, 2013, Aug-15, Volume: 122, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Female; Flow Cytometry; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoglobulin Heavy Chains; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Pyrimidines; Real-Time Polymerase Chain Reaction; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Thiazoles; Vincristine; Young Adult

2013
[Experimental study of remaxol as a drug for supportive therapy in traditional and high-dose treatment of tumors].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Etoposide; Gemcitabine; Methotrexate; Mice; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Succinates

2013
F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia.
    Biological research for nursing, 2014, Volume: 16, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers; Child; Child, Preschool; Dose-Response Relationship, Drug; F2-Isoprostanes; Female; Humans; Male; Methotrexate; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
A validated LC-MS/MS method for rapid determination of methotrexate in human saliva and its application to an excretion evaluation study.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Oct-15, Volume: 937

    Topics: Adult; Antimetabolites, Antineoplastic; Chromatography, Liquid; Drug Stability; Female; Humans; Limit of Detection; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Saliva; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2013
Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells.
    Anti-cancer drugs, 2014, Volume: 25, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cytidine; DNA Modification Methylases; Drug Antagonism; Drug Resistance, Neoplasm; Drug Synergism; Humans; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Aryl Hydrocarbon; Vincristine

2014
An importance of identification of double variant methylenetetrahydrofolate reductase gene C677T and A1298C in cis configuration for pharmacogenetic studies.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2013, Volume: 24, Issue:7

    Topics: Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Precursor Cell Lymphoblastic Leukemia-Lymphoma

2013
Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:7

    Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Homocysteine; Humans; Liver Function Tests; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylhomocysteine

2014
Serum creatinine and creatinine clearance for predicting plasma methotrexate concentrations after high-dose methotrexate chemotherapy for the treatment for childhood lymphoblastic malignancies.
    Cancer chemotherapy and pharmacology, 2014, Volume: 73, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Creatinine; Female; Humans; Lymphoma, Non-Hodgkin; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
Herpes simplex virus reactivation and disease during treatment for childhood acute lymphoblastic leukemia.
    Klinische Padiatrie, 2014, Volume: 226, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Encephalitis, Herpes Simplex; Fatal Outcome; Female; Hematopoietic Stem Cell Transplantation; Herpes Simplex; Humans; Induction Chemotherapy; Infant; Male; Mercaptopurine; Methotrexate; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Simplexvirus; Stomatitis, Herpetic; Vincristine; Virus Activation

2014
Creatinine clearance rate and serum creatinine concentration are related to delayed methotrexate elimination in children with lymphoblastic malignancies.
    Neoplasma, 2014, Volume: 61, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Creatinine; Female; Humans; Lymphoma, Non-Hodgkin; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic leukemia and its interaction with MTHFR C677T and A1298C polymorphisms.
    International journal of laboratory hematology, 2014, Volume: 36, Issue:4

    Topics: Alleles; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Epistasis, Genetic; Female; Gene Frequency; Genetic Predisposition to Disease; Greece; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2014
Influence of pre-hydration and pharmacogenetics on plasma methotrexate concentration and renal dysfunction following high-dose methotrexate therapy.
    International journal of hematology, 2013, Volume: 98, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Kidney; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multidrug Resistance-Associated Protein 2; Odds Ratio; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2013
Low-level laser in prevention and treatment of oral mucositis in pediatric patients with acute lymphoblastic leukemia.
    Photomedicine and laser surgery, 2013, Volume: 31, Issue:12

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Humans; Infant; Low-Level Light Therapy; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Treatment Outcome

2013
Dexamethasone, methotrexate, ifosfamide, L-asparaginase and etoposide (SMILE) chemotherapy for relapsed or refractory adult lymphoblastic lymphoma.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:9

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Etoposide; Humans; Ifosfamide; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2014
Comparison of long-term outcome between white and Vietnamese children treated for acute lymphoblastic leukemia according to the FRALLE 2000 protocol.
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:7

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asian People; Belgium; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Treatment Outcome; Vietnam; White People; Young Adult

2014
Neurocognitive and neuroradiologic central nervous system late effects in children treated on Pediatric Oncology Group (POG) P9605 (standard risk) and P9201 (lesser risk) acute lymphoblastic leukemia protocols (ACCL0131): a methotrexate consequence? A rep
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cognition Disorders; Female; Humans; Infant; Intelligence Tests; Leukoencephalopathies; Magnetic Resonance Imaging; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Risk Factors; Treatment Outcome

2014
50 years ago in the Journal of Pediatrics: central nervous system complications of children with acute leukemia: an evaluation of treatment methods.
    The Journal of pediatrics, 2014, Volume: 164, Issue:1

    Topics: Central Nervous System Diseases; Child; Evaluation Studies as Topic; History, 20th Century; Humans; Injections, Spinal; Methotrexate; Periodicals as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; United States

2014
Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:6

    Topics: Adolescent; Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Evaluation; Female; Guanine Nucleotides; Humans; Hyperbilirubinemia; Hypoxanthine Phosphoribosyltransferase; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Xanthine Oxidase

2014
Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: influence on cure rates and risk of second cancer.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cohort Studies; Cytogenetic Analysis; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Genotype; Humans; Infant; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Pharmacogenetics; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Risk Factors

2014
Association of ABCC2 -24C>T polymorphism with high-dose methotrexate plasma concentrations and toxicities in childhood acute lymphoblastic leukemia.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Infant; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
High relapse rate of T cell acute lymphoblastic leukemia in adults treated with Hyper-CVAD chemotherapy in Sweden.
    European journal of haematology, 2014, Volume: 92, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Betamethasone; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Survival Analysis; Sweden; Transplantation, Homologous; Vincristine

2014
[Single institution experience of HLA-haploidentical hematopoietic stem cell transplantation for children: current problems and perspective].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Female; Graft vs Host Disease; Haploidy; Hematopoietic Stem Cell Transplantation; Histocompatibility; HLA Antigens; Humans; Immunosuppressive Agents; Infant; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Survival Rate; Tacrolimus; Transplantation Conditioning

2014
Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Mar-20, Volume: 32, Issue:9

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Germ-Line Mutation; Humans; Leucovorin; Leukoencephalopathies; Logistic Models; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors

2014
Association of -24CT, 1249GA, and 3972CT ABCC2 gene polymorphisms with methotrexate serum levels and toxic side effects in children with acute lymphoblastic leukemia.
    Pediatric hematology and oncology, 2014, Volume: 31, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Female; Genotype; Humans; Infant; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
Inadequate folinic acid rescue after methotrexate causing neurocognitive and neuroradiological central nervous system late effects in children with acute lymphatic leukemia.
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:6

    Topics: Cognition Disorders; Female; Humans; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
In reply.
    Journal of pediatric hematology/oncology, 2014, Volume: 36, Issue:6

    Topics: Cognition Disorders; Female; Humans; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate.
    Journal of pharmacokinetics and pharmacodynamics, 2014, Volume: 41, Issue:2

    Topics: Administration, Intravenous; Administration, Oral; Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Computer Simulation; Humans; Infant; Infant, Newborn; Methotrexate; Models, Biological; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Values; Tissue Distribution; Young Adult

2014
Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 2: 6-mercaptopurine and its interaction with methotrexate.
    Journal of pharmacokinetics and pharmacodynamics, 2014, Volume: 41, Issue:2

    Topics: Administration, Intravenous; Administration, Oral; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Computer Simulation; Drug Interactions; Humans; Infant; Infant, Newborn; Mercaptopurine; Methotrexate; Models, Biological; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tissue Distribution; Young Adult

2014
Associations of novel genetic variations in the folate-related and ARID5B genes with the pharmacokinetics and toxicity of high-dose methotrexate in paediatric acute lymphoblastic leukaemia.
    British journal of haematology, 2014, Volume: 166, Issue:3

    Topics: Adolescent; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; DNA-Binding Proteins; Female; Folic Acid; Gene Frequency; Genetic Variation; Genotype; Humans; Infant; Male; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transcription Factors

2014
High-dose methotrexate in Egyptian pediatric acute lymphoblastic leukemia: the impact of ABCG2 C421A genetic polymorphism on plasma levels, what is next?
    Journal of cancer research and clinical oncology, 2014, Volume: 140, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Child; Child, Preschool; Egypt; Female; Genetic Association Studies; Humans; Infant; Male; Methotrexate; Neoplasm Proteins; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tissue Distribution

2014
Methotrexate pharmacology in leukaemia cells -letter to the editor.
    Annales Academiae Medicae Stetinensis, 2013, Volume: 59, Issue:1

    Topics: Child; Drug Resistance, Neoplasm; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

2013
[Correlation analysis of FPGS rs10760502G>a polymorphism with prognosis and MTX-related toxicity in pediatric B-cell acute lymphoblastic leukemia].
    Zhongguo shi yan xue ye xue za zhi, 2014, Volume: 22, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Female; Genotype; Humans; Infant; Leukemia, B-Cell; Male; Methotrexate; Peptide Synthases; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2014
Viral-associated trichodysplasia secondary to antineoplastic treatment in a patient with lymphoblastic leukemia.
    The American Journal of dermatopathology, 2014, Volume: 36, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Hair Diseases; Humans; Ichthyosis; Immunocompromised Host; Male; Mercaptopurine; Methotrexate; Polyomavirus Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2014, Volume: 74, Issue:2

    Topics: Adolescent; Asian People; Child; Child, Preschool; DNA; Female; Follow-Up Studies; gamma-Glutamyl Hydrolase; Humans; Immunoenzyme Techniques; Infant; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Peptide Synthases; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2014
Effects of a microRNA binding site polymorphism in SLC19A1 on methotrexate concentrations in Chinese children with acute lymphoblastic leukemia.
    Medical oncology (Northwood, London, England), 2014, Volume: 31, Issue:7

    Topics: Adolescent; Antimetabolites, Antineoplastic; Asian People; Binding Sites; Child; Child, Preschool; Female; Gene Frequency; Humans; Infant; Male; Methotrexate; MicroRNAs; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2014
[Methotrexate toxicity during acute leukemia lymphoblastic].
    The Pan African medical journal, 2014, Volume: 17

    Topics: Antimetabolites, Antineoplastic; Cheilitis; Female; Humans; Methotrexate; Oral Ulcer; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2014
Prescriptions for a toxic combination: use of methotrexate plus trimethoprim-sulfamethoxazole in the United States.
    Southern medical journal, 2014, Volume: 107, Issue:5

    Topics: Adult; Aged; Ambulatory Care; Anti-Infective Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Health Care Surveys; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Pancytopenia; Practice Patterns, Physicians'; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prescriptions; Risk Assessment; Risk Factors; Trimethoprim, Sulfamethoxazole Drug Combination; United States

2014
Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia.
    Pharmacogenetics and genomics, 2014, Volume: 24, Issue:8

    Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Child, Preschool; Female; Genotype; Humans; Infant; Lebanon; Liver-Specific Organic Anion Transporter 1; Male; Mercaptopurine; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Retrospective Studies; Treatment Outcome

2014
Epidural blood patch in leukemia patient: a case report.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:8

    Topics: Antimetabolites, Antineoplastic; Blood Patch, Epidural; Flow Cytometry; Humans; Injections, Spinal; Male; Methotrexate; Middle Aged; Post-Dural Puncture Headache; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
Augmented Berlin-Frankfurt-Münster therapy in adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL).
    Cancer, 2014, Dec-01, Volume: 120, Issue:23

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cohort Studies; Consolidation Chemotherapy; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Female; Humans; Induction Chemotherapy; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Thioguanine; Treatment Outcome; Vincristine; Young Adult

2014
Cure rates of childhood acute lymphoblastic leukemia in Lithuania and the benefit of joining international treatment protocol.
    Medicina (Kaunas, Lithuania), 2014, Volume: 50, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Incidence; Lithuania; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome; Young Adult

2014
Impact of SLCO1B1 521T > C variant on leucovorin rescue and risk of relapse in childhood acute lymphoblastic leukemia treated with high-dose methotrexate.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Genotype; Humans; Leucovorin; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Organic Anion Transporters; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Risk Factors

2014
Prognostic factors in adolescent and adult patients with acute lymphoblastic leukemia with two protocols of chemotherapy: a cross-sectional study.
    Clinical lymphoma, myeloma & leukemia, 2015, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Consolidation Chemotherapy; Cross-Sectional Studies; Cyclophosphamide; Cytarabine; Female; Humans; Induction Chemotherapy; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Retrospective Studies; Treatment Outcome; Vincristine; Young Adult

2015
Assessment of renal function during high-dose methotrexate treatment in children with acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:12

    Topics: Acute-Phase Proteins; Adolescent; Antimetabolites, Antineoplastic; beta 2-Microglobulin; Biomarkers; Child; Child, Preschool; Creatinine; Cystatin C; Dose-Response Relationship, Drug; Feasibility Studies; Female; Follow-Up Studies; Humans; Kidney Function Tests; Lipocalin-2; Lipocalins; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Proto-Oncogene Proteins

2014
Medication errors on oral chemotherapy in children with acute lymphoblastic leukemia in a developing country.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:12

    Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cross-Sectional Studies; Developing Countries; Dexamethasone; Drug Prescriptions; Female; Follow-Up Studies; Humans; Infant; Male; Medication Errors; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies

2014
SLC19A1 hot spot for MTX plasma concentration.
    Medical oncology (Northwood, London, England), 2014, Volume: 31, Issue:10

    Topics: Female; Humans; Male; Methotrexate; MicroRNAs; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2014
Idiopathic Hyperammonemia That Developed During Initial Treatment With Steroid in a Patient With Newly Diagnosed Leukemia.
    Journal of pediatric hematology/oncology, 2015, Volume: 37, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Hydrocortisone; Hyperammonemia; Lactulose; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis

2015
Are concerns about folic acid supplementation in children with acute lymphoblastic leukemia justified?
    Indian pediatrics, 2014, Volume: 51, Issue:9

    Topics: Antineoplastic Agents; Drug Interactions; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2014
Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies.
    Pharmacogenomics, 2014, Volume: 15, Issue:11

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Asian People; Female; Genotype; Hematologic Neoplasms; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Young Adult

2014
[Adolescent and young adult Philadelphia negative B cell acute lymphoblastic leukemia: results of the Chilean protocol LLA 15-30].
    Revista medica de Chile, 2014, Volume: 142, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cohort Studies; Dexamethasone; Female; Humans; Male; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Treatment Outcome; Vincristine; Young Adult

2014
Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heterozygote; Humans; Leukopenia; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Myelopoiesis; Nucleic Acid Synthesis Inhibitors; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk; Scandinavian and Nordic Countries; Survival Analysis

2015
Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia.
    The pharmacogenomics journal, 2015, Volume: 15, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Genotype; Humans; Infant; Male; Methotrexate; Mucositis; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

2015
Severe neurotoxicity following intrathecal methotrexate with nitrous oxide sedation in a child with acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:3

    Topics: Analgesics, Non-Narcotic; Child; Female; Humans; Immunosuppressive Agents; Injections, Spinal; Intracranial Hemorrhages; Methotrexate; Neurotoxicity Syndromes; Nitrous Oxide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography

2015
Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS).
    Blood, 2015, Jan-29, Volume: 125, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Astrocytes; Blood Proteins; c-Mer Tyrosine Kinase; Case-Control Studies; Cell Survival; Central Nervous System; Child; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Coculture Techniques; Female; Galectin 3; Galectins; Gene Expression Regulation, Leukemic; Glioma; Humans; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Cell Culture; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Receptor Protein-Tyrosine Kinases; RNA, Small Interfering; Signal Transduction; Translocation, Genetic; Tumor Cells, Cultured

2015
A simple but very important missing point about intrathecal chemotherapy.
    Hematological oncology, 2016, Volume: 34, Issue:2

    Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2016
Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.
    Experimental hematology, 2015, Volume: 43, Issue:1

    Topics: Animals; Antineoplastic Agents; Biopsy; Clone Cells; Cytarabine; Deoxycytidine Kinase; Dexamethasone; Disease Progression; DNA, Neoplasm; Drug Resistance, Neoplasm; Female; Gene Dosage; Heterografts; Humans; Male; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Neoplasm Proteins; Neoplasm Transplantation; Neoplastic Stem Cells; Peptide Synthases; Polymorphism, Single Nucleotide; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Radiation Chimera; Sequence Analysis, DNA; Vincristine

2015
Superior outcome using cyclosporin A alone versus cyclosporin A plus methotrexate for post-transplant immunosuppression in children with acute leukemia undergoing sibling hematopoietic stem cell transplantation.
    Journal of cancer research and clinical oncology, 2015, Volume: 141, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Cyclosporine; Disease-Free Survival; Female; Germany; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Prevention; Retrospective Studies; Severity of Illness Index; Siblings; Treatment Outcome; Young Adult

2015
Acute encephalomyelitis complicated with severe neurological sequelae after intrathecal administration of methotrexate in a patient with acute lymphoblastic leukemia.
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:11

    Topics: Acute Disease; Brain; Child, Preschool; Diffusion Magnetic Resonance Imaging; Encephalomyelitis; Female; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Severity of Illness Index; Spinal Cord

2014
[SLCO1B1c. 521T>C gene polymorphisms are associated with high-dose methotrexate pharmacokinetics and clinical outcome of pediatric acute lymphoblastic leukemia].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2014, Volume: 52, Issue:10

    Topics: Alleles; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Daunorubicin; Disease-Free Survival; Genotype; Humans; Leucovorin; Liver-Specific Organic Anion Transporter 1; Methotrexate; Organic Anion Transporters; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome; Vincristine

2014
A novel mechanism of toxic injury to the Papez circuit from chemotherapy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015, Volume: 22, Issue:4

    Topics: Adolescent; Brain; Cytarabine; Drug Delivery Systems; Humans; Magnetic Resonance Imaging; Memory Disorders; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2015
Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia.
    The pharmacogenomics journal, 2015, Volume: 15, Issue:4

    Topics: Acute Disease; Adolescent; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Denmark; Genotype; Haplotypes; Humans; Infant; Male; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Recurrence; Risk Assessment; Treatment Outcome

2015
Mycophenolate-based graft versus host disease prophylaxis is not inferior to methotrexate in myeloablative-related donor stem cell transplantation.
    American journal of hematology, 2015, Volume: 90, Issue:5

    Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Cyclosporine; Cytomegalovirus; Cytomegalovirus Infections; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Myeloablative Agonists; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Survival Analysis; Tissue Donors; Transplantation Conditioning; Transplantation, Homologous

2015
[Influence of thymidylate synthase gene polymorphisms on high-dose methotrexate-related toxicities in childhood acute lymphoblastic leukemia].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2015, Volume: 17, Issue:1

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Infant; Male; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase

2015
[Dasatinib-related pneumonia? An example of pharmacovigilance survey].
    Revue des maladies respiratoires, 2015, Volume: 32, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Middle Aged; Pharmacovigilance; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recombinant Proteins; Thiazoles; Tomography, X-Ray Computed; Vincristine

2015
Myelopathy following intrathecal chemotherapy in adults: a single institution experience.
    Journal of neuro-oncology, 2015, Volume: 122, Issue:2

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Cytarabine; Female; Humans; Injections, Spinal; Leukemia, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord; Spinal Cord Diseases

2015
Mercaptopurine metabolite levels are predictors of bone marrow toxicity following high-dose methotrexate therapy of childhood acute lymphoblastic leukaemia.
    Cancer chemotherapy and pharmacology, 2015, Volume: 75, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythrocytes; Female; Guanine Nucleotides; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Thrombocytopenia

2015
Toxicity profile and treatment delays in NOPHO ALL2008-comparing adults and children with Philadelphia chromosome-negative acute lymphoblastic leukemia.
    European journal of haematology, 2016, Volume: 96, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Middle Aged; Osteonecrosis; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Thrombosis; Treatment Outcome; Vincristine

2016
Survival of Mexican Children with Acute Lymphoblastic Leukaemia under Treatment with the Protocol from the Dana-Farber Cancer Institute 00-01.
    BioMed research international, 2015, Volume: 2015

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Mexico; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Treatment Outcome; United States; Vincristine

2015
Clinical Course of Cerebral Venous Thrombosis in Adult Acute Lymphoblastic Leukemia.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2015, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cerebrovascular Disorders; Clinical Trials, Phase II as Topic; Drug Administration Schedule; Female; Headache; Humans; Injections, Spinal; Male; Methotrexate; Middle Aged; Netherlands; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Retrospective Studies; Risk Factors; Seizures; Spinal Puncture; Time Factors; Venous Thromboembolism; Venous Thrombosis; Young Adult

2015
Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia.
    Journal of hematology & oncology, 2015, May-29, Volume: 8

    Topics: Adolescent; Child; Drug Resistance, Neoplasm; Female; Humans; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2015
Treatment of young children with CNS-positive acute lymphoblastic leukemia without cranial radiotherapy.
    Pediatric blood & cancer, 2015, Volume: 62, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child, Preschool; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate

2015
Does genetic susceptibility increase risk for neurocognitive decline among patients with acute lymphoblastic leukemia?
    Future oncology (London, England), 2015, Volume: 11, Issue:13

    Topics: Economics, Pharmaceutical; Genetic Predisposition to Disease; Humans; Methotrexate; Neurocognitive Disorders; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

2015
Evaluating Intestinal Permeability by Measuring Plasma Endotoxin and Diamine Oxidase in Children with Acute Lymphoblastic Leukemia Treated with High-dose Methotrexate.
    Anti-cancer agents in medicinal chemistry, 2016, Volume: 16, Issue:3

    Topics: Amine Oxidase (Copper-Containing); Antimetabolites, Antineoplastic; Child; Endotoxins; Humans; Infant; Intestinal Mucosa; Limulus Test; Methotrexate; Permeability; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spectrophotometry; Survival Rate

2016
Evaluation of serum and urine fetuin-A levels in children with acute lymphoblastic leukemia during and after high-dose methotrexate therapy: Relation to toxicity.
    Hematology (Amsterdam, Netherlands), 2016, Volume: 21, Issue:2

    Topics: Adolescent; alpha-2-HS-Glycoprotein; Child; Child, Preschool; Female; Humans; Infant; Kidney Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2016
Is a New Protocol for Acute Lymphoblastic Leukemia Research or Standard Therapy?
    Pediatrics, 2015, Volume: 136, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Clinical Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Evidence-Based Medicine; Humans; Leucovorin; Mercaptopurine; Methotrexate; Netherlands; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Assessment; Therapeutic Human Experimentation; United States; Vincristine

2015
Influence of dihydrofolate reductase gene polymorphisms rs408626 (-317A>G) and rs442767 (-680C>A) on the outcome of methotrexate-based maintenance therapy in South Indian patients with acute lymphoblastic leukemia.
    European journal of clinical pharmacology, 2015, Volume: 71, Issue:11

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Treatment Outcome; White People; Young Adult

2015
Association of ABCB1, ABCC5 and xanthine oxidase genetic polymorphisms with methotrexate adverse reactions in Mexican pediatric patients with ALL.
    Drug metabolism and personalized therapy, 2015, Volume: 30, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Cancer Care Facilities; Child; Child, Preschool; Female; Genetic Association Studies; Humans; Maintenance Chemotherapy; Male; Methotrexate; Mexico; Multidrug Resistance-Associated Proteins; Myelopoiesis; Pharmacovigilance; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Xanthine Oxidase

2015
Persistent and Prolonged Parvovirus B19 Viremia in a Pediatric Patient With Acute Lymphoblastic Leukemia.
    Journal of the Pediatric Infectious Diseases Society, 2015, Volume: 4, Issue:3

    Topics: Antineoplastic Agents; Asymptomatic Infections; Child; Humans; Immunocompromised Host; Immunoglobulins, Intravenous; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Parvoviridae Infections; Parvovirus B19, Human; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Viremia

2015
TPMT gene expression is increased during maintenance therapy in childhood acute lymphoblastic leukemia patients in a TPMT gene promoter variable number of tandem repeat-dependent manner.
    Pharmacogenomics, 2015, Volume: 16, Issue:15

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow; Child; Child, Preschool; Female; Gene Expression Regulation, Neoplastic; Humans; Infant; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Minisatellite Repeats; Monocytes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic

2015
Impact of therapy in a cohort of unselected children with Down Syndrome-associated Acute Lymphoblastic Leukaemia.
    British journal of haematology, 2016, Volume: 174, Issue:6

    Topics: Anthracyclines; Child; Child, Preschool; Cohort Studies; Down Syndrome; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Treatment Outcome

2016
Patients' Adherence in the Maintenance Therapy of Children and Adolescents with Acute Lymphoblastic Leukemia.
    Klinische Padiatrie, 2015, Volume: 227, Issue:6-7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Female; Food-Drug Interactions; Humans; Infant; Maintenance Chemotherapy; Male; Medication Adherence; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Surveys and Questionnaires

2015
Functional variants of gene encoding folate metabolizing enzyme and methotrexate-related toxicity in children with acute lymphoblastic leukemia.
    European journal of pharmacology, 2015, Dec-15, Volume: 769

    Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Gene Frequency; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2015
Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.
    International journal of cancer, 2016, Apr-01, Volume: 138, Issue:7

    Topics: Adult; Alternative Splicing; Antineoplastic Agents; Blotting, Western; Child; Drug Resistance, Neoplasm; Female; Flow Cytometry; Humans; Male; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction

2016
Serum Creatinine Versus Plasma Methotrexate Levels to Predict Toxicities in Children Receiving High-dose Methotrexate.
    Pediatric hematology and oncology, 2015, Volume: 32, Issue:8

    Topics: Adolescent; Child; Child, Preschool; Creatinine; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2015
CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:9

    Topics: Alleles; Amino Acid Substitution; Child; Child, Preschool; Cyclin D1; Drug Resistance, Neoplasm; Female; Genotype; Humans; Liver; Male; Methotrexate; Mutation; Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2015
Extreme Spindles and Leukoencephalopathy after Acute Lymphoblastic Leukemia Treatment: An Undescribed Association.
    The Neurodiagnostic journal, 2015, Volume: 55, Issue:4

    Topics: Child, Preschool; Diagnosis, Differential; Electroencephalography; Humans; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2015
[Clinical and Prognostic analysis of 43 Children with Mature B-cell Non-Hodgkin's Lymphoma/Acute Lymphoblastic Leukemia].
    Zhongguo shi yan xue ye xue za zhi, 2016, Volume: 24, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Cyclophosphamide; Cytarabine; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Hydrocortisone; Leucovorin; Logistic Models; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Multivariate Analysis; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Retrospective Studies; Survival Rate; Vincristine

2016
The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia.
    Haematologica, 2016, Volume: 101, Issue:7

    Topics: Adolescent; Child; Child, Preschool; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Male; Methotrexate; Neoplasm Proteins; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA Splicing; Survival Rate

2016
Alternating hemiparesis and orolingual apraxia as manifestations of methotrexate neurotoxicity in a paediatric case of acute lymphoblastic leukaemia.
    BMJ case reports, 2016, Apr-25, Volume: 2016

    Topics: Adolescent; Antimetabolites, Antineoplastic; Apraxias; Brain; Female; Humans; Injections, Spinal; Methotrexate; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2016
Concomitant Presentation of Hemophagocytic Lymphohistiocytosis and Posttransplant Lymphoproliferative Disease-Like Lymphoma in a Mildly Immunosuppressed Leukemia Patient: An Unusual Association.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:8

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cyclosporine; Dexamethasone; Epstein-Barr Virus Infections; Etoposide; Female; Humans; Immunocompromised Host; Infant; Lymphohistiocytosis, Hemophagocytic; Male; Mercaptopurine; Methotrexate; Multiple Organ Failure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rituximab; Treatment Failure; Vincristine; Viral Load

2016
Association Between Combined Presence of Hepatitis C Virus and Polymorphisms in Different Genes With Toxicities of Methotrexate and 6-Mercaptopurine in Children With Acute Lymphoblastic Leukemia.
    Pediatric blood & cancer, 2016, Volume: 63, Issue:9

    Topics: Child; Child, Preschool; Female; Genotype; Hepacivirus; Humans; Liver; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2016
Impact of complete molecular response on survival in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
    Blood, 2016, 07-28, Volume: 128, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Infant; Male; Methotrexate; Neoplasm, Residual; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Vincristine

2016
Intracranial Hemorrhage Following Intrathecal Methotrexate Therapy for Acute Lymphoblastic Leukaemia.
    Indian pediatrics, 2016, May-08, Volume: 53, Issue:5

    Topics: Antineoplastic Agents; Brain; Child, Preschool; Female; Humans; Injections, Spinal; Intracranial Hemorrhages; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2016
Chemotherapy Pharmacodynamics and Neuroimaging and Neurocognitive Outcomes in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016, 08-01, Volume: 34, Issue:22

    Topics: Adolescent; Child; Executive Function; Female; Frontal Lobe; Humans; Intelligence; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Male; Methotrexate; Neuroimaging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prefrontal Cortex; Treatment Outcome

2016
Wernicke's encephalopathy in a child with Down syndrome, undergoing treatment for acute lymphoblastic leukemia.
    Pediatrics international : official journal of the Japan Pediatric Society, 2016, Volume: 58, Issue:8

    Topics: Antimetabolites, Antineoplastic; Brain; Child; Down Syndrome; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Wernicke Encephalopathy

2016
Measures of 6-mercaptopurine and methotrexate maintenance therapy intensity in childhood acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:5

    Topics: Adolescent; Aging; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Child; Child, Preschool; Female; Genotype; Humans; Leukocyte Count; Leukopenia; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; PTEN Phosphohydrolase; Risk Assessment

2016
MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia.
    Pharmacogenetics and genomics, 2016, Volume: 26, Issue:11

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Male; Methotrexate; MicroRNAs; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein; Retrospective Studies; Spain; White People

2016
Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 10-04, Volume: 113, Issue:40

    Topics: Base Sequence; Cell Line, Tumor; Clonal Evolution; Drug Resistance, Neoplasm; Genes, ras; Humans; Methotrexate; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2016
Leukoencephalopathy and long-term neurobehavioural, neurocognitive, and brain imaging outcomes in survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy: a longitudinal analysis.
    The Lancet. Haematology, 2016, Volume: 3, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Behavior Rating Scale; Child; Child Behavior Disorders; Cognition Disorders; Cranial Irradiation; Dexamethasone; Diffusion Tensor Imaging; Female; Humans; Injections, Spinal; Intelligence Tests; Leukoencephalopathies; Longitudinal Studies; Magnetic Resonance Imaging; Male; Memory, Short-Term; Methotrexate; Neuropsychological Tests; Observational Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Survivors; Treatment Outcome; White Matter

2016
Development and validation of LC-MS/MS assay for the simultaneous determination of methotrexate, 6-mercaptopurine and its active metabolite 6-thioguanine in plasma of children with acute lymphoblastic leukemia: Correlation with genetic polymorphism.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Dec-01, Volume: 1038

    Topics: Antimetabolites, Antineoplastic; Child; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Mercaptopurine; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid Phase Extraction; Tandem Mass Spectrometry; Thioguanine

2016
Using a Bedside Algorithm to Individually Dose High-dose Methotrexate for Patients at Risk for Toxicity.
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:1

    Topics: Acute Kidney Injury; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Fluid Therapy; Humans; Infusions, Intravenous; Methotrexate; Mucositis; Nervous System Diseases; Point-of-Care Systems; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2017
Drug-resistant epilepsy after treatment for childhood acute lymphocytic leukaemia: from focal epilepsy to Lennox-Gastaut syndrome.
    Epileptic disorders : international epilepsy journal with videotape, 2016, Dec-01, Volume: 18, Issue:4

    Topics: Antimetabolites, Antineoplastic; Cranial Irradiation; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Humans; Lennox Gastaut Syndrome; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2016
Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil.
    Bone marrow transplantation, 2017, Volume: 52, Issue:3

    Topics: Adolescent; Adult; Cord Blood Stem Cell Transplantation; Cyclosporine; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Incidence; Japan; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Registries; Survival Rate; Tacrolimus

2017
Graft-Versus-Host Disease in Adolescents and Young Adults (15-24 Years Old) After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Leukemia in First Complete Remission.
    Journal of adolescent and young adult oncology, 2017, Volume: 6, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Child; Chronic Disease; Cyclosporine; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Incidence; Intestinal Diseases; Leukemia, Myeloid, Acute; Methotrexate; Mortality; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Quality of Life; Remission Induction; Severity of Illness Index; Skin Diseases; Survival Rate; Transplantation, Homologous; Young Adult

2017
Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Dec-17, Volume: 22

    Topics: Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Gene Frequency; Humans; Male; Methotrexate; Peptide Synthases; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2016
The Conundrum in the Diagnosis and Management of Atypical Fulminant Measles in a Leukemia Survivor on Maintenance Chemotherapy.
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:1

    Topics: Adrenal Cortex Hormones; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Cryptogenic Organizing Pneumonia; Diagnostic Errors; Extracorporeal Membrane Oxygenation; Fatal Outcome; Humans; Lymphohistiocytosis, Hemophagocytic; Maintenance Chemotherapy; Male; Measles; Mercaptopurine; Methotrexate; Multiple Organ Failure; Pancytopenia; Picornaviridae Infections; Plasma Exchange; Pneumonia, Viral; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rhinovirus; Sepsis; Survivors

2017
Hepatotoxicity During Maintenance Therapy and Prognosis in Children With Acute Lymphoblastic Leukemia.
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:3

    Topics: Adolescent; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Infant; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

2017
Long-term brain structural magnetic resonance imaging and cognitive functioning in children treated for acute lymphoblastic leukemia with high-dose methotrexate chemotherapy alone or combined with CNS radiotherapy at reduced total dose to 12 Gy.
    Neuroradiology, 2017, Volume: 59, Issue:2

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Treatment Outcome; Young Adult

2017
Survival Outcome of Filipino Children With Acute Lymphoblastic Leukemia Treated With Modified Berlin-Frankfurt-Muenster/Hong Kong Acute Lymphoblastic Leukemia (BFM95/HKALL97) Protocol in a Tertiary General Hospital From January 2005 to December 2009: A Re
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cohort Studies; Consolidation Chemotherapy; Daunorubicin; Disease-Free Survival; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Philippines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Tertiary Care Centers; Treatment Outcome; Vincristine

2017
Sinusoidal Obstruction Syndrome During Maintenance Therapy for Acute Lymphoblastic Leukemia With 6-Mercaptopurine and Methotrexate: A Pediatric Case Report.
    Journal of pediatric hematology/oncology, 2017, Volume: 39, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Biopsy; Child; Drug Interactions; Hepatic Veno-Occlusive Disease; Humans; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Multimodal Imaging; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2017
A Stroke Mimic: Methotrexate-induced Neurotoxicity in the Emergency Department.
    The Journal of emergency medicine, 2017, Volume: 52, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Combined Modality Therapy; Dextromethorphan; Emergency Service, Hospital; Excitatory Amino Acid Antagonists; Facial Paralysis; Female; Humans; Lower Extremity; Methotrexate; Muscle Hypotonia; Muscle Weakness; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; Upper Extremity

2017
Repeated Episodes of Leukoencephalopathy after High-dose Methotrexate in a Child with Acute Lymphoblastic Leukemia.
    Indian pediatrics, 2017, 02-15, Volume: 54, Issue:2

    Topics: Adolescent; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Female; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2017
mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia.
    Blood, 2008, Sep-01, Volume: 112, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cyclin D; Cyclins; Drug Resistance, Neoplasm; Drug Synergism; Humans; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein Kinases; Tetrahydrofolate Dehydrogenase; TOR Serine-Threonine Kinases; Transplantation, Heterologous

2008
Pure motor lumbosacral radiculopathy after intrathecal chemotherapy.
    European journal of neurology, 2008, Volume: 15, Issue:8

    Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Dexamethasone; Humans; Hydrocortisone; Injections, Spinal; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Middle Aged; Paraparesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiculopathy; Sacrum; Spinal Nerve Roots; Vincristine

2008
[Association between mthfr gene polymorphisms and toxicity of HDMTX chemotherapy in acute lymphocytic leukemia].
    Zhongguo shi yan xue ye xue za zhi, 2008, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2008
Prophylaxis of central nervous system leukemia: a case of chronic myeloid leukemia with lymphoid blast crisis treated with imatinib mesylate.
    World journal of pediatrics : WJP, 2008, Volume: 4, Issue:2

    Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast Crisis; Blood Cell Count; Central Nervous System Neoplasms; Chemoprevention; Child; Clinical Protocols; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Imatinib Mesylate; Injections, Spinal; Methotrexate; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction

2008
Treatment of pediatric acute lymphoblastic leukemia.
    Haematologica, 2008, Volume: 93, Issue:8

    Topics: Antineoplastic Agents; Blast Crisis; Child; Child, Preschool; Humans; Injections, Spinal; Meningeal Neoplasms; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Risk Factors

2008
Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate.
    European journal of haematology, 2008, Volume: 81, Issue:5

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Cytarabine; Female; Humans; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neutropenia; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Thrombocytopenia

2008
Immune reconstitution during maintenance therapy in children with acute lymphoblastic leukemia, relation to co-existing infection.
    Hematology (Amsterdam, Netherlands), 2008, Volume: 13, Issue:4

    Topics: Adolescent; Adrenal Cortex Hormones; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Case-Control Studies; CD4-CD8 Ratio; Child; Child, Preschool; Female; Humans; Immunoglobulins; Infections; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2008
Severe neurotoxicities in a case of Charcot-Marie-Tooth disease type 2 caused by vincristine for acute lymphoblastic leukemia.
    Journal of pediatric hematology/oncology, 2008, Volume: 30, Issue:7

    Topics: Adolescent; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Charcot-Marie-Tooth Disease; Contraindications; Cytarabine; Daunorubicin; Etoposide; Gait Disorders, Neurologic; Humans; Male; Mercaptopurine; Methotrexate; Muscle Weakness; Neural Conduction; Peripheral Nervous System Diseases; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine

2008
Outcome and toxicity of chemotherapy for acute lymphoblastic leukemia in children with Down syndrome.
    Pediatric blood & cancer, 2009, Volume: 52, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Dose-Response Relationship, Drug; Down Syndrome; Humans; Matched-Pair Analysis; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Survival Analysis; Treatment Outcome

2009
Recurrent intrathecal methotrexate induced neurotoxicity in an adolescent with acute lymphoblastic leukemia: Serial clinical and radiologic findings.
    Pediatric blood & cancer, 2009, Volume: 52, Issue:2

    Topics: Adolescent; Diffusion; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Speech Disorders

2009
Marked increase of normal blast morphologically mimicking leukemic clone in acute lymphoblastic leukemia patient following G-CSF therapy.
    International journal of hematology, 2008, Volume: 88, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Granulocyte Colony-Stimulating Factor; Humans; Lymphocyte Activation; Lymphocytes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recovery of Function; Remission Induction; Time Factors

2008
Veno-occlusive disease of the liver during induction therapy for acute lymphoblastic leukemia.
    International journal of hematology, 2008, Volume: 88, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Daunorubicin; Female; Fibrinolytic Agents; Hepatic Veno-Occlusive Disease; Humans; Liver; Marfan Syndrome; Methotrexate; Middle Aged; Polydeoxyribonucleotides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine

2008
Practice of central nervous system prophylaxis and treatment in acute leukemias in Spain. Prospective registry study.
    Medicina clinica, 2008, Oct-04, Volume: 131, Issue:11

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Injections, Spinal; Leukemia, Myeloid, Acute; Liposomes; Longitudinal Studies; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Registries; Spain

2008
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity.
    Pediatric blood & cancer, 2009, Volume: 52, Issue:1

    Topics: Adolescent; Cerebrospinal Fluid; Child; Child, Preschool; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
Intractable epilepsy in patients treated for childhood acute lymphocytic leukemia.
    Seizure, 2009, Volume: 18, Issue:4

    Topics: Adult; Antirheumatic Agents; Brain; Cranial Irradiation; Epilepsy; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
MTHFR 677 C>T genotype and adverse outcomes in treatment of childhood ALL: is the jury in?
    Pediatric blood & cancer, 2009, Volume: 52, Issue:3

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Antineoplastic Agents; Child; Cytosine; Genotype; Humans; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2009
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
    Blood, 2009, May-07, Volume: 113, Issue:19

    Topics: Biomarkers, Tumor; Cation Transport Proteins; Cell Line, Transformed; Cells, Cultured; Child; Child, Preschool; Female; Formins; Gene Dosage; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Genetic Predisposition to Disease; Genetic Variation; Genome, Human; Humans; Infant; Malate Dehydrogenase; Male; Methotrexate; Microfilament Proteins; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Phenotype; Phosphoric Monoester Hydrolases; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Smad2 Protein; Smad4 Protein; Tumor Suppressor Proteins

2009
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia.
    Pediatric neurology, 2009, Volume: 40, Issue:1

    Topics: Administration, Oral; Adolescent; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Dementia, Vascular; Folic Acid; Folic Acid Antagonists; Homeostasis; Homocysteine; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; tau Proteins; Young Adult

2009
[Effects of high-dose methotrexate therapy on intestinal bacterial flora in children with acute lymphoblastic leukemia].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2008, Volume: 46, Issue:4

    Topics: Antimetabolites, Antineoplastic; Bacillus; Case-Control Studies; Child; Child, Preschool; DNA, Bacterial; Escherichia coli; Feces; Female; Humans; Intestines; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2008
White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors.
    International journal of radiation oncology, biology, physics, 2009, Jul-01, Volume: 74, Issue:3

    Topics: Adolescent; Analysis of Variance; Anisotropy; Antimetabolites, Antineoplastic; Brain Neoplasms; Case-Control Studies; Child; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Humans; Intelligence; Internal Capsule; Medulloblastoma; Mental Processes; Methotrexate; Motor Activity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Statistics, Nonparametric; Survivors

2009
Intrathecal methotrexate-induced acute chorea.
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:1

    Topics: Acute Disease; Antimetabolites, Antineoplastic; Child; Chorea; Female; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2009
Poor treatment compliance in children with down syndrome and acute lymphoblastic leukemia.
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Down Syndrome; Female; Guideline Adherence; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Patient Compliance; Physician's Role; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Survival Rate; Treatment Outcome

2009
Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
    Blood, 2009, Apr-30, Volume: 113, Issue:18

    Topics: Adult; Alternative Splicing; Blotting, Northern; Cell Proliferation; Drug Resistance, Neoplasm; Exons; Folic Acid; Folic Acid Antagonists; Humans; Immunoenzyme Techniques; Introns; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Distribution

2009
[A retrospective analysis of clinical outcomes in 225 childhood with acute lymphoblastic leukemia].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2008, Volume: 29, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome

2008
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
    JAMA, 2009, Jan-28, Volume: 301, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Etoposide; Female; Flow Cytometry; Follow-Up Studies; Genotype; Germ-Line Mutation; Humans; Infant; Linear Models; Linkage Disequilibrium; Male; Methotrexate; Neoplasm, Residual; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Retrospective Studies; Risk Assessment; Risk Factors

2009
Relationship between HLA-DP supertype and survival in childhood acute lymphoblastic leukaemia: evidence for selective loss of immunological control of residual disease?
    British journal of haematology, 2009, Volume: 145, Issue:1

    Topics: Adolescent; Biomarkers, Tumor; Chi-Square Distribution; Child; Child, Preschool; Disease-Free Survival; Female; Genetic Predisposition to Disease; Genotype; HLA-DP Antigens; HLA-DP beta-Chains; Humans; Immunosuppressive Agents; Infant; Kaplan-Meier Estimate; Male; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Randomized Controlled Trials as Topic; Statistics, Nonparametric; Treatment Outcome

2009
Changes in acetylcholinesterase (AchE) activity in lymphocytes and whole blood in acute lymphoblastic leukemia patients.
    Clinica chimica acta; international journal of clinical chemistry, 2009, Volume: 402, Issue:1-2

    Topics: Acetylcholinesterase; Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cytarabine; Female; Humans; Lymphocytes; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2009
Effective treatment of advanced-stage childhood lymphoblastic lymphoma without prophylactic cranial irradiation: results of St Jude NHL13 study.
    Leukemia, 2009, Volume: 23, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Etoposide; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; T-Lymphocytes; Treatment Outcome; Vincristine

2009
Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.
    Blood, 2009, Jun-11, Volume: 113, Issue:24

    Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Humans; Immunoenzyme Techniques; Infant; Karyotyping; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Factors; Stem Cell Transplantation; Survival Rate; Treatment Outcome

2009
High-dose methotrexate: the rationale...
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:3

    Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
Additional chromosomal abnormalities and their prognostic significance in adult Philadelphia-positive acute lymphoblastic leukemia: with or without imatinib in chemotherapy.
    Annals of hematology, 2009, Volume: 88, Issue:11

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamides; Chromosome Aberrations; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Etoposide; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Pyrimidines; Salvage Therapy; Vincristine; Vindesine; Young Adult

2009
Adults with acute lymphoblastic leukemia and translocation (1;19) abnormality have a favorable outcome with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and high-dose cytarabine chemotherapy
    Cancer, 2009, May-15, Volume: 115, Issue:10

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Humans; Methotrexate; Middle Aged; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Translocation, Genetic; Treatment Outcome; Vincristine

2009
Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma.
    British journal of haematology, 2009, Volume: 145, Issue:3

    Topics: Aminopterin; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Humans; Inhibitory Concentration 50; Lymphoma; Methotrexate; Mice; Mice, SCID; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Regression Analysis; Xenograft Model Antitumor Assays

2009
Mesial temporal sclerosis associated with methotrexate-induced leukoencephalopathy.
    Pediatric neurology, 2009, Volume: 40, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child, Preschool; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Methotrexate; Positron-Emission Tomography; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sclerosis; Temporal Lobe

2009
Posterior reversible encephalopathy syndrome associated with methotrexate neurotoxicity: conventional magnetic resonance and diffusion-weighted imaging findings.
    Journal of child neurology, 2009, Volume: 24, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Diseases; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Humans; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Phlebography; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Status Epilepticus; Syndrome

2009
False-photosensitivity and transient hemiparesis following high-dose intravenous and intrathecal methotrexate for treatment of acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2009, Volume: 53, Issue:1

    Topics: Adolescent; Dysarthria; False Positive Reactions; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Nucleic Acid Synthesis Inhibitors; Paresis; Photosensitivity Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

2009
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity.
    Pediatric blood & cancer, 2009, Volume: 53, Issue:1

    Topics: Adolescent; Brain Infarction; Child; Child, Preschool; Demyelinating Diseases; Facial Paralysis; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
Successful treatment of human metapneumovirus pneumonia using combination therapy with intravenous ribavirin and immune globulin.
    British journal of haematology, 2009, Volume: 145, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Asparaginase; Child, Preschool; Combined Modality Therapy; Daunorubicin; Female; Humans; Immunocompromised Host; Immunoglobulins, Intravenous; Metapneumovirus; Methotrexate; Paramyxoviridae Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Ribavirin; Vincristine

2009
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.
    Leukemia & lymphoma, 2009, Volume: 50, Issue:6

    Topics: Adolescent; Alleles; Anemia; Antimetabolites, Antineoplastic; Bone Marrow; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Gene Frequency; Genotype; Humans; Kidney; Liver; Lymphoma, Non-Hodgkin; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytopenia; Time Factors

2009
Intracranial pressure in pediatric patients with acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2009, Volume: 53, Issue:3

    Topics: Child; Humans; Intracranial Pressure; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.
    Biochemical pharmacology, 2009, Apr-15, Volume: 77, Issue:8

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Child; Drug Resistance, Neoplasm; Folic Acid; Gene Expression Profiling; Humans; Methotrexate; Nucleotides; Oligonucleotide Array Sequence Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes

2009
Oxidative stress and executive function in children receiving chemotherapy for acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2009, Volume: 53, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Emotions; Female; Humans; Male; Memory; Methotrexate; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Verbal Behavior

2009
Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia.
    Blood, 2009, Aug-13, Volume: 114, Issue:7

    Topics: Adolescent; Alleles; Amino Acid Substitution; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Gene Frequency; Genotype; Humans; Male; Mercaptopurine; Methotrexate; Multidrug Resistance-Associated Proteins; Mutation, Missense; Pilot Projects; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Retrospective Studies; Survival Rate

2009
On the malignant potential of thiopurine therapy.
    Blood, 2009, Jun-11, Volume: 113, Issue:24

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cranial Irradiation; Humans; Hypoxanthine Phosphoribosyltransferase; Immunoenzyme Techniques; Karyotyping; Mercaptopurine; Methotrexate; Methyltransferases; Mutation; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Factors; Stem Cell Transplantation; Survival Rate; Treatment Outcome

2009
Toxic non-resorptive internal hydrocephalus as a result of haemorrhagic ventriculitis during induction chemotherapy of Bcr-Abl positive acute lymphoblastic leukaemia.
    Annals of hematology, 2010, Volume: 89, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain; Cerebral Ventricles; Cyclophosphamide; Female; Fusion Proteins, bcr-abl; Humans; Hydrocephalus; Magnetic Resonance Imaging; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2010
[Prophylaxis and treatment of modified BFM-90 regimen for lymphoblastic lymphoma in children and adolescents accompanied with infection].
    Ai zheng = Aizheng = Chinese journal of cancer, 2009, Volume: 28, Issue:7

    Topics: Adolescent; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Cephalosporins; Child; Child, Preschool; Cross Infection; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Progression; Female; Humans; Itraconazole; Male; Mercaptopurine; Methotrexate; Mouth Diseases; Mycoses; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Respiratory Tract Infections; Vincristine

2009
Voxel-based analysis of T2 hyperintensities in white matter during treatment of childhood leukemia.
    AJNR. American journal of neuroradiology, 2009, Volume: 30, Issue:10

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Cerebral Ventricles; Child; Child, Preschool; Female; Frontal Lobe; Humans; Infant; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Nerve Fibers, Myelinated; Parietal Lobe; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors

2009
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.
    Haematologica, 2009, Volume: 94, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Follow-Up Studies; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Tetrahydrofolate Dehydrogenase; Young Adult

2009
Serendipity-methotrexate and 6-mercaptopurine for continuation therapy for patients with acute lymphoblastic leukemia: the leukemic stem cell and beyond?
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:6

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
Molecular genetic analysis of a primitive neuroectodermal tumor arising after intracranial radiation and chemotherapy for leukemia.
    Annals of clinical and laboratory science, 2009,Summer, Volume: 39, Issue:3

    Topics: Adult; Bone Marrow Transplantation; Brain; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 17; Cranial Irradiation; Humans; Loss of Heterozygosity; Magnetic Resonance Imaging; Male; Methotrexate; Neuroectodermal Tumors, Primitive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-ret; PTEN Phosphohydrolase; Tumor Suppressor Protein p53; Whole-Body Irradiation

2009
Germline genomic variants associated with childhood acute lymphoblastic leukemia.
    Nature genetics, 2009, Volume: 41, Issue:9

    Topics: Alleles; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 7; Cohort Studies; DNA-Binding Proteins; Dopa Decarboxylase; Gene Dosage; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Germ Cells; Germ-Line Mutation; Haplotypes; Humans; Ikaros Transcription Factor; Linkage Disequilibrium; Methotrexate; Odds Ratio; Oncogene Proteins, Fusion; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Probability; Reproducibility of Results; Risk Factors; Trans-Activators; Transcription Factors; White People

2009
Weight patterns in children with higher risk ALL: A report from the Children's Oncology Group (COG) for CCG 1961.
    Pediatric blood & cancer, 2009, Dec-15, Volume: 53, Issue:7

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Mass Index; Child; Child, Preschool; Cranial Irradiation; Cytarabine; Daunorubicin; Ethnicity; Female; Gastrointestinal Diseases; Glucose Intolerance; Humans; Incidence; Male; Methotrexate; Obesity; Pancreatitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Vincristine; Weight Gain; Weight Loss; Young Adult

2009
Acute methotrexate neurotoxicity with choreiform movements and focal neurological deficits: a case report.
    Southern medical journal, 2009, Volume: 102, Issue:10

    Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Ataxia; Brain; Chorea; Confusion; Headache; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Nausea; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reflex, Abnormal

2009
Evaluation of the late effects of CNS prophylactic treatment in childhood acute lymphoblastic leukemia (ALL) using magnetic resonance spectroscopy.
    Acta neurochirurgica. Supplement, 2010, Volume: 106

    Topics: Adolescent; Aspartic Acid; Brain Injuries; Case-Control Studies; Child; Child, Preschool; Choline; Cranial Irradiation; Creatine; Drug Administration Routes; Drug Therapy; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tissue Distribution

2010
Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia.
    Cancer, 2010, Jan-01, Volume: 116, Issue:1

    Topics: Allopurinol; Child; Child, Preschool; Female; Humans; Hyperuricemia; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Urate Oxidase; Uric Acid

2010
Random serum methotrexate determinations for assessing compliance with maintenance therapy for childhood acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2009, Volume: 50, Issue:11

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Immunoassay; Interviews as Topic; Male; Methotrexate; Monitoring, Physiologic; Outcome Assessment, Health Care; Patient Compliance; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2009
DNA variants in region for noncoding interfering transcript of dihydrofolate reductase gene and outcome in childhood acute lymphoblastic leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Nov-15, Volume: 15, Issue:22

    Topics: Adult; Case-Control Studies; Child; Cohort Studies; DNA; Female; Genetic Variation; Haplotypes; Humans; Male; Methotrexate; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Tetrahydrofolate Dehydrogenase

2009
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Dec-10, Volume: 27, Issue:35

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Gastrointestinal Diseases; Genetic Predisposition to Disease; Genome-Wide Association Study; Germ-Line Mutation; Humans; Infant; Linear Models; Linkage Disequilibrium; Liver-Specific Organic Anion Transporter 1; Logistic Models; Male; Methotrexate; Organic Anion Transporters; Phenotype; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Assessment; Risk Factors; Treatment Outcome

2009
Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2010, Volume: 21, Issue:1

    Topics: Alleles; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Egypt; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasm Proteins; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Stomatitis; Vincristine

2010
Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses.
    Pediatric blood & cancer, 2010, Volume: 54, Issue:4

    Topics: Adolescent; Age of Onset; Antineoplastic Agents; Brain; Brain Mapping; Child; Child, Preschool; Cytarabine; Female; Humans; Intelligence Tests; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Short-Term; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors

2010
DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma.
    Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytosol; DNA; Drug Monitoring; Erythrocytes; Female; Guanine Nucleotides; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thionucleotides

2010
[Blood concentration monitoring during high-dose methotrexate treatment].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2009, Volume: 31, Issue:5

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Drug Monitoring; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2009
The impact of high-dose methotrexate on intracellular 6-mercaptopurine disposition during interval therapy of childhood acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biotransformation; Child; Child, Preschool; Drug Interactions; Erythrocytes; Female; Humans; Inactivation, Metabolic; Injections, Intravenous; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine

2010
Prospective bone ultrasound patterns during childhood acute lymphoblastic leukemia treatment.
    Bone, 2010, Volume: 46, Issue:4

    Topics: Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Bone Density; Chi-Square Distribution; Child; Child, Preschool; Cyclophosphamide; Cytosine; Female; Fractures, Bone; Humans; Male; Mercaptopurine; Methotrexate; Osteonecrosis; Osteoporosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Time Factors; Ultrasonography; Vincristine

2010
Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy.
    Leukemia, 2010, Volume: 24, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; CCAAT-Binding Factor; Cell Line, Tumor; Exons; Gene Expression Regulation, Enzymologic; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Methotrexate; Peptide Synthases; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sp1 Transcription Factor; Vorinostat

2010
Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy.
    Journal of pediatric hematology/oncology, 2010, Volume: 32, Issue:2

    Topics: Adaptation, Psychological; Adolescent; Antineoplastic Agents; Brain; Child; Child Behavior; Child, Preschool; Female; Humans; Male; Methotrexate; Oxidation-Reduction; Oxidative Stress; Phosphatidylcholines; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2010
Relationship of the reduced folate carrier gene polymorphism G80A to methotrexate plasma concentration, toxicity, and disease outcome in childhood acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2010, Volume: 51, Issue:4

    Topics: Adolescent; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Predisposition to Disease; Humans; Male; Membrane Transport Proteins; Methotrexate; Osmolar Concentration; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Reduced Folate Carrier Protein; Treatment Outcome; Young Adult

2010
Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico.
    Leukemia research, 2010, Volume: 34, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Female; gamma-Glutamyl Hydrolase; Gene Frequency; Genotype; Humans; Infant; Male; Methotrexate; Mexico; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk; Treatment Outcome

2010
Solar burn reactivation induced by methotrexate.
    Pharmacotherapy, 2010, Volume: 30, Issue:4

    Topics: Acute Disease; Acute Kidney Injury; Adolescent; Antineoplastic Agents, Phytogenic; Blood Urea Nitrogen; Creatinine; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sunburn; Treatment Outcome; Ultraviolet Rays; Vincristine

2010
Hyperperfusion on magnetic resonance imaging in acute chemotherapy-related leukoencephalopathy.
    Journal of child neurology, 2010, Volume: 25, Issue:6

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Diagnosis, Differential; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Male; Methotrexate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; Vincristine

2010
Methotrexate-induced side effects are not due to differences in pharmacokinetics in children with Down syndrome and acute lymphoblastic leukemia.
    Haematologica, 2010, Volume: 95, Issue:7

    Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Dose-Response Relationship, Drug; Down Syndrome; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2010
New agents for the treatment of patients with acute lymphoblastic leukemia.
    Current hematologic malignancy reports, 2008, Volume: 3, Issue:3

    Topics: Age Factors; Antibodies, Monoclonal; Asparaginase; Disease-Free Survival; Enzyme Inhibitors; HSP90 Heat-Shock Proteins; Humans; Liposomes; Methotrexate; Nucleosides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Notch; Recurrence

2008
Prospective study of hemostatic alterations in children with acute lymphoblastic leukemia.
    American journal of hematology, 2010, Volume: 85, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Antithrombins; Asparaginase; Case-Control Studies; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Fibrin Fibrinogen Degradation Products; Humans; Infant; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; P-Selectin; Plasminogen Activator Inhibitor 1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Risk Factors; Thrombin; Thrombophilia; Venous Thromboembolism; Vincristine; von Willebrand Factor

2010
Pontomedullary hemorrhage due to vascular malformation of basilar artery after treatment for acute lymphoblastic leukemia.
    Pediatric hematology and oncology, 2010, Volume: 27, Issue:4

    Topics: Antimetabolites, Antineoplastic; Arteries; Child, Preschool; Combined Modality Therapy; Humans; Injections, Spinal; Intracranial Arterial Diseases; Intracranial Hemorrhages; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography; Radiotherapy Dosage

2010
Guillain-Barré syndrome mimicking acute methotrexate-associated encephalopathy in an adolescent patient with lymphoblastic lymphoma.
    Journal of pediatric hematology/oncology, 2010, Volume: 32, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Diseases; Diagnosis, Differential; Female; Guillain-Barre Syndrome; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2010
Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution.
    Leukemia & lymphoma, 2010, Volume: 51, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Electroencephalography; Female; Humans; Infant; Leukemic Infiltration; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Tomography, X-Ray Computed; Vincristine

2010
Folylpolyglutamate synthetase gene transcription is regulated by a multiprotein complex that binds the TEL-AML1 fusion in acute lymphoblastic leukemia.
    Leukemia research, 2010, Volume: 34, Issue:12

    Topics: Antimetabolites, Antineoplastic; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Leukemic; Histone Deacetylase 1; Methotrexate; Multiprotein Complexes; Oncogene Proteins, Fusion; Peptide Synthases; Pre-B-Cell Leukemia Transcription Factor 1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Proto-Oncogene Proteins; Retinoblastoma Protein; Transcription, Genetic

2010
Spinal cord compression by epidural involvement over 21 vertebral levels in acute lymphoblastic leukemia.
    Journal of pediatric hematology/oncology, 2011, Volume: 33, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Epidural Neoplasms; Humans; Lumbar Vertebrae; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Sacrococcygeal Region; Spinal Cord Compression; Thoracic Vertebrae; Vincristine

2011
Anthracycline dose intensification in adult acute lymphoblastic leukemia: lack of benefit in the context of the fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimen.
    Cancer, 2010, Oct-01, Volume: 116, Issue:19

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Drug Administration Schedule; Humans; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Salvage Therapy; Treatment Outcome; Vincristine

2010
Overt testicular disease at diagnosis in childhood acute lymphoblastic leukemia: prognostic significance and role of testicular irradiation.
    Indian journal of pediatrics, 2010, Volume: 77, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Male; Methotrexate; Multivariate Analysis; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Testicular Neoplasms

2010
Old drug--new insights--better treatment?
    Leukemia research, 2010, Volume: 34, Issue:12

    Topics: Antimetabolites, Antineoplastic; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Leukemic; Histone Deacetylase 1; Methotrexate; Multiprotein Complexes; Oncogene Proteins, Fusion; Peptide Synthases; Pre-B-Cell Leukemia Transcription Factor 1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Proto-Oncogene Proteins; Retinoblastoma Protein; Transcription, Genetic

2010
Cognitive reserve and brain volumes in pediatric acute lymphoblastic leukemia.
    Brain imaging and behavior, 2010, Volume: 4, Issue:3-4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Child; Child, Preschool; Cognition; Cognitive Reserve; Female; Humans; Image Processing, Computer-Assisted; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors; Treatment Outcome; Young Adult

2010
Chemotherapy-related delayed bilateral spontaneous pneumothorax and lung fibrosis: methotrexate or cyclophosphamide, or both?
    The clinical respiratory journal, 2010, Volume: 4, Issue:4

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Humans; Male; Methotrexate; Pneumothorax; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Fibrosis; Radiography

2010
Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis.
    American journal of hematology, 2011, Volume: 86, Issue:1

    Topics: Antimetabolites, Antineoplastic; Child, Preschool; Female; Folic Acid; Humans; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
The sequence of application of methotrexate and histone deacetylase inhibitors determines either a synergistic or an antagonistic response in childhood acute lymphoblastic leukemia cells.
    Leukemia, 2011, Volume: 25, Issue:2

    Topics: Cell Line, Tumor; Child; Drug Antagonism; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
Outcome of treatment of adult acute lymphoblastic leukemia with hyperfractionated cyclophosphamide, doxorubicin, vincristine, dexamethasone/methotrexate, cytarabine: results from an Australian population.
    Leukemia & lymphoma, 2011, Volume: 52, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Australia; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Treatment Outcome; Vincristine; Young Adult

2011
Transient leukoencephalopathy after intrathecal methotrexate mimicking stroke.
    Emergency radiology, 2011, Volume: 18, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Female; Humans; Injections, Spinal; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke

2011
The effect of cerebral spinal fluid replacement on acute myelopathy induced by intrathecal therapy of leukemia.
    Leukemia research, 2011, Volume: 35, Issue:6

    Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cerebrospinal Fluid; Cytarabine; Dexamethasone; Female; Fluid Therapy; Humans; Injections, Spinal; Methotrexate; Paraplegia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Treatment Outcome

2011
AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.
    Molecular cancer therapeutics, 2011, Volume: 10, Issue:3

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Apoptosis; Carbon; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Endoplasmic Reticulum; Humans; Methotrexate; Molecular Targeted Therapy; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Ribonucleotides; Signal Transduction

2011
Erythroblastic islands.
    Blood, 2011, Jan-06, Volume: 117, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Combined Modality Therapy; Dexamethasone; Erythroblasts; Erythropoiesis; Female; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2011
Cellular elements of the subarachnoid space promote ALL survival during chemotherapy.
    Leukemia research, 2011, Volume: 35, Issue:6

    Topics: Antineoplastic Agents; Astrocytes; Cell Communication; Cell Line, Tumor; Cell Survival; Cells, Cultured; Choroid Plexus; Coculture Techniques; Cytarabine; Dexamethasone; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Meninges; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Subarachnoid Space; Time Factors

2011
Severe hypoglycemic seizures in a child receiving 6-mercaptopurine.
    Journal of pediatric hematology/oncology, 2011, Volume: 33, Issue:2

    Topics: Anti-Infective Agents; Antimetabolites, Antineoplastic; Child, Preschool; Humans; Hypoglycemia; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Trimethoprim, Sulfamethoxazole Drug Combination

2011
Folate fortification and survival of children with acute lymphoblastic leukemia.
    Paediatric drugs, 2011, Jun-01, Volume: 13, Issue:3

    Topics: Child; Child, Preschool; Databases, Factual; Folic Acid; Folic Acid Antagonists; Food, Fortified; Humans; Infant; Infant, Newborn; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Analysis; Treatment Failure; World Health Organization

2011
Methotrexate pharmacokinetics in childhood acute lymphoblastic leukaemia: a prognostic value?
    Journal of clinical pharmacy and therapeutics, 2011, Volume: 36, Issue:2

    Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Area Under Curve; Bayes Theorem; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Models, Biological; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Time Factors

2011
Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2011, Volume: 57, Issue:4

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Infant; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Organic Anion Transporters; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2011
Autism Speaks: meeting on folate metabolism and Autism spectrum disorders, March 19-20, 2009, Washington, DC.
    Journal of pediatric hematology/oncology, 2011, Volume: 33, Issue:3

    Topics: Autistic Disorder; Biological Transport; Brain; Cognition Disorders; District of Columbia; Folic Acid; Genomic Instability; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, N-Methyl-D-Aspartate; Vitamin B 12

2011
[A case of the association of acute lymphoblastic lymphoma with active tuberculosis in the child: a Malian case].
    Le Mali medical, 2010, Volume: 25, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child, Preschool; Cytarabine; Humans; Injections, Intramuscular; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Tuberculosis, Pulmonary; Vincristine

2010
Towards personalized medicine - the role of methotrexate.
    The Indian journal of medical research, 2011, Volume: 133

    Topics: Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma.
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:10

    Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child, Preschool; Female; Folic Acid; Genotype; Humans; Lymphoma; Male; Metabolic Networks and Pathways; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Nonlinear Dynamics; Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Retrospective Studies; Thrombocytopenia

2011
Methotrexate leukoencephalopathy mimics acute progressive stroke.
    Journal of neurology, 2011, Volume: 258, Issue:11

    Topics: Adolescent; Antimetabolites, Antineoplastic; Diagnosis, Differential; Humans; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke

2011
Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population.
    Leukemia & lymphoma, 2011, Volume: 52, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asian People; Child; Child, Preschool; China; Drug-Related Side Effects and Adverse Reactions; Female; Gene Frequency; Genotype; Haplotypes; Humans; Infant; Linkage Disequilibrium; Logistic Models; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neutropenia; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Skin Diseases; Thrombocytopenia

2011
Genotyping of single nucleotide polymorphism in γ-glutamyl hydrolase gene by capillary electrophoresis.
    Electrophoresis, 2011, Volume: 32, Issue:15

    Topics: Antimetabolites, Antineoplastic; Electrophoresis, Capillary; gamma-Glutamyl Hydrolase; Genotype; Humans; Hypromellose Derivatives; Methotrexate; Methylcellulose; Polymorphism, Single Nucleotide; Polymorphism, Single-Stranded Conformational; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temperature

2011
Methotrexate toxicity and efficacy during the consolidation phase in paediatric acute lymphoblastic leukaemia and MTHFR polymorphisms as pharmacogenetic determinants.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:5

    Topics: Child; Child, Preschool; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymerase Chain Reaction; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
Suspicion of drug-drug interaction between high-dose methotrexate and proton pump inhibitors: a case report - should the practice be changed?
    Chemotherapy, 2011, Volume: 57, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acyclovir; Antimetabolites, Antineoplastic; Antiviral Agents; Drug Interactions; Female; Fluoxetine; Humans; Methotrexate; Middle Aged; Pantoprazole; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proton Pump Inhibitors; Renal Insufficiency; Valacyclovir; Valine

2011
Polymorphism in multidrug resistance-associated protein gene 3 is associated with outcomes in childhood acute lymphoblastic leukemia.
    The pharmacogenomics journal, 2012, Volume: 12, Issue:5

    Topics: Alleles; Biomarkers, Pharmacological; Disease-Free Survival; Genetic Association Studies; Genotype; Haplotypes; Humans; Methotrexate; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2012
Cord blood transplantation from unrelated donors for children with acute lymphoblastic leukemia in Japan: the impact of methotrexate on clinical outcomes.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2011, Volume: 17, Issue:12

    Topics: Blood Platelets; Child; Child, Preschool; Cord Blood Stem Cell Transplantation; Female; Graft vs Host Disease; Humans; Infant, Newborn; Japan; Male; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk Factors; Survival Rate; Transplantation Conditioning; Treatment Outcome; Unrelated Donors; Whole-Body Irradiation

2011
Ultrafast selective quantification of methotrexate in human plasma by high-throughput MALDI-isotope dilution mass spectrometry.
    Bioanalysis, 2011, Volume: 3, Issue:12

    Topics: Deuterium; Drug Stability; Fluorescence Polarization Immunoassay; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry

2011
A rare complication of intrathecal methotrexate in a child with acute lymphoblastic leukemia.
    Pediatric hematology and oncology, 2011, Volume: 28, Issue:6

    Topics: Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Child; Dexamethasone; Female; Humans; Injections, Spinal; Leucovorin; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography; Time Factors; Vitamin B Complex

2011
Numb chin syndrome in acute lymphoblastic leukemia.
    Indian pediatrics, 2011, Volume: 48, Issue:6

    Topics: Antineoplastic Agents; Child; Chin; Cytarabine; Female; Humans; Hypesthesia; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Skull

2011
Methotrexate consolidation treatment according to pharmacogenetics of MTHFR ameliorates event-free survival in childhood acute lymphoblastic leukaemia.
    The pharmacogenomics journal, 2012, Volume: 12, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Genotype; Humans; Infant, Newborn; Kaplan-Meier Estimate; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses.
    Cancer, 2012, Feb-01, Volume: 118, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Staging; Neuromuscular Junction Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Rate; Survivors; Vincristine; Young Adult

2012
Are we getting closer to using methotrexate in an optimal manner?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Sep-01, Volume: 29, Issue:25

    Topics: Antimetabolites, Antineoplastic; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
MTHFR 677TT genotype and toxicity of methotrexate: controversial results.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:5

    Topics: Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2011
Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia.
    Leukemia research, 2011, Volume: 35, Issue:11

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Blotting, Western; Brain Injuries; Child; Child, Preschool; Doublecortin Domain Proteins; Doublecortin Protein; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Methotrexate; Microtubule-Associated Proteins; Nerve Growth Factors; Neuropeptides; Neuroprotective Agents; Phosphopyruvate Hydratase; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Up-Regulation

2011
Somatosensory evoked potential for detection of subclinical neuropathy in Egyptian children with acute lymphoblastic leukaemia.
    Pakistan journal of biological sciences : PJBS, 2010, Jun-01, Volume: 13, Issue:11

    Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Computer Simulation; Egypt; Electrodes; Electrophysiology; Evoked Potentials, Somatosensory; Female; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk

2010
Homozygosity for the rs9939609T allele of the FTO gene may have protective effect on becoming overweight in survivors of childhood acute lymphoblastic leukaemia.
    Journal of genetics, 2011, Volume: 90, Issue:2

    Topics: Adolescent; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Genetic Association Studies; Homozygote; Humans; Male; Methotrexate; Obesity; Odds Ratio; Overweight; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proteins; Radiotherapy; Risk Factors; Survivors; Thioguanine; Vincristine; Young Adult

2011
Strength capacity in young patients who are receiving maintenance therapy for acute lymphoblastic leukemia: a case-control study.
    Clinics (Sao Paulo, Brazil), 2011, Volume: 66, Issue:7

    Topics: Adolescent; Age Factors; Antineoplastic Agents; Case-Control Studies; Child; Dexamethasone; Female; Humans; Male; Mercaptopurine; Methotrexate; Muscle Strength; Muscle Stretching Exercises; Muscle Weakness; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Sex Factors; Time Factors; Vincristine

2011
The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.
    Clinical laboratory, 2011, Volume: 57, Issue:7-8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biotransformation; Bone Neoplasms; Child; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence Polarization Immunoassay; Humans; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult

2011
[An extremely high serum methotrexate concentration associated with acute renal failure in a patient with acute lymphoblastic leukemia after conduction of high dose consolidation].
    Terapevticheskii arkhiv, 2011, Volume: 83, Issue:7

    Topics: Acute Kidney Injury; Adult; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Humans; Kidney Function Tests; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction

2011
[Pharmacokinetic analysis of high-dose methotrexate treatments in children with hematologic malignancies].
    Orvosi hetilap, 2011, Oct-02, Volume: 152, Issue:40

    Topics: Adolescent; Antimetabolites, Antineoplastic; Blood Proteins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Creatinine; Drug Administration Schedule; Female; Humans; Kidney; Liver; Liver Failure; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency; Stomatitis; Time Factors; Treatment Outcome

2011
Important role of caspase-8 for chemosensitivity of ALL cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Dec-15, Volume: 17, Issue:24

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 8; Cell Line, Tumor; Cell Survival; Child; Cytarabine; Dexamethasone; Doxorubicin; Enzyme Activation; Humans; Jurkat Cells; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA Interference; Thioguanine; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2011
Role of base-excision repair in the treatment of childhood acute lymphoblastic leukaemia with 6-mercaptopurine and high doses of methotrexate.
    Mutation research, 2012, Jan-24, Volume: 741, Issue:1-2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Child; Child, Preschool; Comet Assay; DNA Damage; DNA Repair; Humans; Hydrogen Peroxide; Lymphocytes; Male; Mercaptopurine; Methotrexate; Oxidation-Reduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Uracil; Young Adult

2012
Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2012, Volume: 53, Issue:6

    Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Female; Folic Acid; Genotype; Humans; Infant; Infant, Newborn; Male; Metabolic Networks and Pathways; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Thymidylate Synthase

2012
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.
    Genome research, 2012, Volume: 22, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Clinical Trials as Topic; Cohort Studies; Exons; Female; Haplotypes; Humans; Infant; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Neoplasm Proteins; Organic Anion Transporters; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Liquid chromatography-tandem mass spectrometry quantification of 6-thioguanine in DNA using endogenous guanine as internal standard.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jan-15, Volume: 881-882

    Topics: Calibration; Child; Chromatography, Liquid; DNA; DNA, Neoplasm; Guanine; Humans; Jurkat Cells; Leukocytes; Limit of Detection; Linear Models; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Thioguanine

2012
Cryptosporidium gastroenteritis in Egyptian children with acute lymphoblastic leukemia: magnitude of the problem.
    Infection, 2012, Volume: 40, Issue:3

    Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Cryptosporidiosis; Cryptosporidium parvum; Diarrhea; Egypt; Entamoeba histolytica; Feces; Female; Gastroenteritis; Giardia lamblia; Gram-Negative Bacteria; Humans; Immunocompromised Host; Immunosuppressive Agents; Infant; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

2012
Experience with high dose methotrexate therapy in childhood acute lymphoblastic leukemia in a tertiary care cancer centre of a developing country.
    Pediatric blood & cancer, 2012, Volume: 59, Issue:3

    Topics: Antimetabolites, Antineoplastic; Cancer Care Facilities; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Leucovorin; Male; Methotrexate; Mucositis; Neutropenia; Patient Readmission; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2012
Effect of high-dose methotrexate chemotherapy on intestinal Bifidobacteria, Lactobacillus and Escherichia coli in children with acute lymphoblastic leukemia.
    Experimental biology and medicine (Maywood, N.J.), 2012, Volume: 237, Issue:3

    Topics: Antimetabolites, Antineoplastic; Bifidobacterium; Child; DNA, Bacterial; Escherichia coli; Female; Humans; Intestinal Mucosa; Lactobacillus; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction

2012
Population analysis of pharmacogenetic polymorphisms related to acute lymphoblastic leukemia drug treatment.
    Disease markers, 2012, Volume: 32, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biotransformation; Brazil; Gene Frequency; Genetic Loci; Genetic Markers; Genotype; Glucocorticoids; HapMap Project; Humans; Mercaptopurine; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Racial Groups; Regression Analysis

2012
High dose methotrexate treatment in childhood ALL: pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity.
    Klinische Padiatrie, 2012, Volume: 224, Issue:3

    Topics: Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genetic Carrier Screening; Genotype; Homozygote; Humans; Leukopenia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pilot Projects; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Treatment Outcome

2012
DNA synthesis as a therapeutic target: the first 65 years.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:6

    Topics: Aminopterin; Antimetabolites, Antineoplastic; DNA Replication; Fluorouracil; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Hydroxyurea; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase

2012
Longitudinal language outcomes following intrathecal chemotherapy for acute lymphoblastic leukaemia.
    International journal of speech-language pathology, 2013, Volume: 15, Issue:2

    Topics: Antineoplastic Agents; Case-Control Studies; Child; Child, Preschool; Cognition; Drug Therapy; Female; Follow-Up Studies; Humans; Injections, Spinal; Language; Language Tests; Longitudinal Studies; Male; Methotrexate; Outcome Assessment, Health Care; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

2013
High incidence of vertebral fractures in children with acute lymphoblastic leukemia 12 months after the initiation of therapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Aug-01, Volume: 30, Issue:22

    Topics: Adolescent; Bone Density; Child; Child, Preschool; Female; Glucocorticoids; Humans; Incidence; Infant; Logistic Models; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Spinal Fractures; Time Factors

2012
Methotrexate sodium-associated UV reactivation in a patient with acute lymphoblastic leukemia.
    Cutis, 2012, Volume: 89, Issue:5

    Topics: Antimetabolites, Antineoplastic; Child; Humans; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sunscreening Agents; Ultraviolet Rays

2012
Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL.
    Pharmacogenomics, 2012, Volume: 13, Issue:9

    Topics: Adolescent; Biomarkers, Pharmacological; Child; Child, Preschool; Female; Folic Acid; Genetic Association Studies; Glutamate Carboxypeptidase II; Haplotypes; Humans; Male; Mercaptopurine; Metabolic Networks and Pathways; Methotrexate; Methyltransferases; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrophosphatases

2012
Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2013, Volume: 54, Issue:3

    Topics: Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Multivariate Analysis; Neuropsychological Tests; Outcome Assessment, Health Care; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sphingomyelins; Time Factors

2013
A second target of benzamide riboside: dihydrofolate reductase.
    Cancer biology & therapy, 2012, Volume: 13, Issue:13

    Topics: Adenine Nucleotides; Benzamides; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Humans; IMP Dehydrogenase; Methotrexate; Molecular Targeted Therapy; NADP; Nucleosides; Phosphotransferases (Alcohol Group Acceptor); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase

2012
[Association between the methylenetetrahydrofolate reductase gene polymorphisms and haplotype with toxicity response of high dose methotrexate chemotherapy].
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2012, Volume: 33, Issue:7

    Topics: Adolescent; Alleles; Child; Child, Preschool; Dose-Response Relationship, Drug; Genotype; Haplotypes; Humans; Infant; Linkage Disequilibrium; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2012
Cytomegalovirus retinitis as an adverse immunological effect of pulses of vincristine and dexamethasone in maintenance therapy for childhood acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2013, Volume: 60, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cytomegalovirus Retinitis; Dexamethasone; Female; Humans; Maintenance Chemotherapy; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2013
Association between polymorphisms of dihydrofolate reductase and gamma glutamyl hydrolase genes and toxicity of high dose methotrexate in children with acute lymphoblastic leukemia.
    Asian Pacific journal of cancer prevention : APJCP, 2012, Volume: 13, Issue:7

    Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Female; gamma-Glutamyl Hydrolase; Gene Frequency; Genotype; Humans; Infant; Leukopenia; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Thrombocytopenia

2012
Delayed elimination of methotrexate by cola beverages in a pediatric acute lymphoblastic leukemia population.
    Leukemia & lymphoma, 2013, Volume: 54, Issue:5

    Topics: Age Factors; Beverages; Child; Cola; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

2013
Prevention of bone growth defects, increased bone resorption and marrow adiposity with folinic acid in rats receiving long-term methotrexate.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Adiposity; Animals; Antimetabolites, Antineoplastic; Apoptosis; Bone Marrow; Bone Resorption; Child; Chondrocytes; Cytokines; Femur; Gene Expression; Humans; Leucovorin; Male; Methotrexate; Osteoblasts; Osteoclasts; Osteogenesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RANK Ligand; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Vitamin B Complex; X-Ray Microtomography

2012
Drug-drug interaction between methotrexate and levetiracetam in a child treated for acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2013, Volume: 60, Issue:2

    Topics: Adolescent; Anticonvulsants; Antineoplastic Agents; Drug Interactions; Drug Therapy, Combination; Humans; Levetiracetam; Male; Methotrexate; Piracetam; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures

2013
Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.
    Cancer research, 2013, Jan-15, Volume: 73, Issue:2

    Topics: Biological Transport; Folic Acid; Folic Acid Antagonists; Glycine; Humans; Methotrexate; Mitochondria; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serine; Transcriptome

2013
[Adverse effects of methotrexate in the treatment of acute lymphoblastic leukemia in Uyghur and Han children].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2012, Volume: 14, Issue:11

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; China; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
'Stroke-like syndrome' caused by intrathecal methotrexate in patients treated during the UKALL 2003 trial.
    Leukemia, 2013, Volume: 27, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Female; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; United Kingdom

2013
Intellectual functioning of childhood leukemia survivors--relation to Tau protein--a marker of white matter injury.
    Advances in medical sciences, 2012, Volume: 57, Issue:2

    Topics: Adolescent; Antineoplastic Agents; Biomarkers; Brain Injuries; Child; Child, Preschool; Cognition Disorders; Female; Humans; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; tau Proteins

2012
C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: effect on methotrexate-related toxicity in adult acute lymphoblastic leukaemia.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2013, Volume: 24, Issue:2

    Topics: Adult; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Real-Time Polymerase Chain Reaction

2013
Chemotherapy for initial induction failures in childhood acute lymphoblastic leukemia: a Children's Oncology Group Study (POG 8764).
    Journal of pediatric hematology/oncology, 2013, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Hydrocortisone; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Teniposide; Treatment Outcome; Young Adult

2013
Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.
    Pharmacogenetics and genomics, 2013, Volume: 23, Issue:2

    Topics: Antimetabolites, Antineoplastic; Biomarkers, Tumor; Child; Female; Haplotypes; Humans; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies

2013
[Treatment outcome of non-Hodgkin lymphoma in childhood: KYCCSG NHL-89, 96].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2012, Volume: 53, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2012
The evaluation of protein Z levels of children with acute lymphoblastic leukaemia during induction therapy.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2013, Volume: 24, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blood Proteins; Case-Control Studies; Child; Child, Preschool; Daunorubicin; Female; Hemorrhage; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Thrombosis; Time Factors; Vincristine

2013
Hypopyon as the first sign of relapse in acute lymphoblastic leukaemia.
    International journal of hematology, 2013, Volume: 97, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Cyclophosphamide; Cytarabine; Doxorubicin; Eye Neoplasms; Fatal Outcome; Female; Humans; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Vincristine

2013
Bone mineral assessment with tibial ultrasonometry and dual-energy X-ray absorptiometry in long-term survivors of acute lymphoblastic leukemia in childhood.
    Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry, 2002,Summer, Volume: 5, Issue:2

    Topics: Absorptiometry, Photon; Adolescent; Adrenal Cortex Hormones; Adult; Antimetabolites, Antineoplastic; Bone Density; Bone Diseases; Child; Cross-Sectional Studies; Disease-Free Survival; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tibia; Ultrasonography

2002
Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:7

    Topics: Antimetabolites, Antineoplastic; Child; Female; gamma-Glutamyl Hydrolase; Humans; Infusions, Intravenous; Male; Methotrexate; Models, Theoretical; Neoplasm Proteins; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2002
Treatment of Czech children with acute lymphoblastic leukemia: a report of the Czech Working Group for Pediatric Hematology.
    Medical and pediatric oncology, 2002, Volume: 39, Issue:2

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Czech Republic; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Immunophenotyping; Infant; Male; Methotrexate; Ploidies; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2002
Symptomatic hypoglycemia in children receiving oral purine analogues for treatment of childhood acute lymphoblastic leukemia.
    Medical and pediatric oncology, 2002, Volume: 39, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blood Glucose; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Hypoglycemia; Italy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Purines; Retrospective Studies; Time Factors; Vincristine

2002
Variant translocations of 11q23 in infant acute lymphoblastic leukemia (ALL): do outcomes differ from t(4;11)?
    Medical and pediatric oncology, 2002, Volume: 39, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 4; Cyclophosphamide; Cytarabine; Cytogenetic Analysis; Daunorubicin; DNA Primers; Female; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Translocation, Genetic; Vincristine

2002
Increased factor VIII activity and dural sinus thrombosis.
    Medical and pediatric oncology, 2002, Volume: 39, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Factor VIII; Humans; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiography; Risk Factors; Sagittal Sinus Thrombosis; Vincristine

2002
Primary cutaneous lymphoblastic lymphoma presenting in an 8-week old infant.
    Journal of cutaneous pathology, 2002, Volume: 29, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Humans; Immunohistochemistry; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Neoplasms; Vincristine

2002
The role of posttransplantation maintenance chemotherapy in improving the outcome of autotransplantation in adult acute lymphoblastic leukemia.
    Blood, 2002, Sep-01, Volume: 100, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Secondary Prevention; Survival Analysis; Transplantation, Autologous; Vincristine

2002
A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT.
    American journal of hematology, 2002, Volume: 71, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Azathioprine; Bone Marrow Transplantation; Cyclophosphamide; Daunorubicin; Drug Therapy, Combination; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Living Donors; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous; Vincristine

2002
Improvement over time in outcome for children with acute lymphoblastic leukemia in second remission given hematopoietic stem cell transplantation from unrelated donors.
    Leukemia, 2002, Volume: 16, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; DNA, Neoplasm; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; HLA-A Antigens; HLA-B Antigens; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Infant; Living Donors; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Registries; Remission Induction; Survival Rate; Time Factors; Transplantation, Homologous; Treatment Outcome; Vincristine

2002
Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia.
    Blood, 2002, Nov-15, Volume: 100, Issue:10

    Topics: Adolescent; Antimetabolites, Antineoplastic; Carrier Proteins; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Folate Receptors, GPI-Anchored; Genotype; Humans; Infant; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Treatment Outcome

2002
Subacute leukencephalopathy after low-dose intrathecal methotrexate in an adolescent heterozygous for the MTHFR C677T polymorphism.
    Medical and pediatric oncology, 2003, Volume: 40, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Heterozygote; Humans; Injections, Spinal; Leukoencephalitis, Acute Hemorrhagic; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2003
Post-induction residual disease in translocation t(12;21)-positive childhood ALL.
    Medical and pediatric oncology, 2003, Volume: 40, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 21; Core Binding Factor Alpha 2 Subunit; DNA Primers; Doxorubicin; Female; Humans; Immunophenotyping; Infant; Male; Methotrexate; Neoplasm, Residual; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Translocation, Genetic; Vincristine

2003
Perfusion MRI and SPECT of brain after treatment for childhood acute lymphoblastic leukemia.
    Medical and pediatric oncology, 2003, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Child; Child, Preschool; Cytarabine; Female; Humans; Iatrogenic Disease; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon; Vincristine

2003
Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for acute lymphoblastic leukemia.
    Cancer, 2002, Dec-15, Volume: 95, Issue:12

    Topics: Antibiotic Prophylaxis; Antimetabolites, Antineoplastic; Atrophy; Brain; Brain Neoplasms; Child; Child, Preschool; Cognition Disorders; Female; Follow-Up Studies; Humans; Infant; Infusions, Intravenous; Intelligence Tests; Magnetic Resonance Imaging; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Radiotherapy, Adjuvant; Survival Rate; Tomography, X-Ray Computed

2002
Treatment: the most important prognostic variable.
    Journal of pediatric hematology/oncology, 2002, Volume: 24, Issue:9

    Topics: Antineoplastic Agents; Diploidy; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Treatment Outcome

2002
Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia.
    Leukemia research, 2003, Volume: 27, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dental Enamel Hypoplasia; Dexamethasone; Doxorubicin; Etoposide; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Odontogenesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Teniposide; Tooth Abnormalities; Tooth Diseases; Tooth Eruption; Tooth Root; Vincristine

2003
Transplantation of peripheral blood stem cells as compared with bone marrow from HLA-identical siblings in adult patients with acute myeloid leukemia and acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Dec-15, Volume: 20, Issue:24

    Topics: Acute Disease; Adolescent; Adult; Age Factors; Bone Marrow Transplantation; Chronic Disease; Disease-Free Survival; Female; Graft vs Host Disease; HLA Antigens; Humans; Immunosuppressive Agents; Leukemia, Myelomonocytic, Acute; Male; Methotrexate; Multivariate Analysis; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2002
[Primary renal non-Hodgkin lymphoma].
    La Tunisie medicale, 2002, Volume: 80, Issue:5

    Topics: Abdominal Pain; Acute Kidney Injury; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Bone Marrow Examination; Cyclophosphamide; Female; Humans; Hydrocortisone; Kidney Neoplasms; Methotrexate; Methylprednisolone; Nausea; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Renal Dialysis; Treatment Outcome; Vincristine; Vomiting

2002
Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm.
    Neurology, 2003, Jan-28, Volume: 60, Issue:2

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Blindness; Brain Diseases; Cerebral Arteries; Cerebral Infarction; Cytarabine; Disease Progression; Female; Humans; Injections, Spinal; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Ocular Motility Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recovery of Function; Syndrome; Tachycardia; Vasospasm, Intracranial

2003
Benign intracranial hypertension in association with acute lymphoblastic leukemia.
    Pediatric hematology and oncology, 2003, Volume: 20, Issue:2

    Topics: Acetazolamide; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chlorthalidone; Cyclophosphamide; Cytarabine; Daunorubicin; Diagnosis, Differential; Headache; Humans; Intracranial Hypertension; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Sinus Thrombosis, Intracranial; Vincristine; Vomiting

2003
[Ocular relapse of acute lymphoblastic leukemia].
    Bulletin de la Societe belge d'ophtalmologie, 2002, Issue:286

    Topics: Administration, Topical; Adrenal Cortex Hormones; Anterior Chamber; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cyclophosphamide; Cytarabine; Dexamethasone; Eye Neoplasms; Fatal Outcome; Humans; Methotrexate; Neoplasm Recurrence, Local; Paracentesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Vincristine

2002
Systemic methotrexate exposure is greater after intrathecal than after oral administration.
    Journal of pediatric hematology/oncology, 2003, Volume: 25, Issue:2

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Child, Preschool; Confidence Intervals; Erythrocytes; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2003
Treatment of acute lymphoblastic leukemia in Hong Kong children: HKALL 93 study.
    Hematological oncology, 2003, Volume: 21, Issue:1

    Topics: Adolescent; Age Factors; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Hong Kong; Humans; Immunophenotyping; Infant; Logistic Models; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Regression Analysis; Salvage Therapy; Time Factors

2003
Successful reintroduction of methotrexate after acute pneumonitis in a patient with acute lymphoblastic leukemia.
    Annals of hematology, 2003, Volume: 82, Issue:3

    Topics: Acute Disease; Female; Humans; Mercaptopurine; Methotrexate; Middle Aged; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Tomography, X-Ray Computed

2003
Methotrexate-induced acral erythema with bullous reaction.
    Dermatology online journal, 2003, Volume: 9, Issue:1

    Topics: Adolescent; Erythema; Humans; Male; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin; Skin Diseases, Vesiculobullous

2003
Induction of long-term remission of a relapsed childhood B-acute lymphoblastic leukemia with rituximab chimeric anti-CD20 monoclonal antibody and autologous stem cell transplantation.
    Journal of pediatric hematology/oncology, 2003, Volume: 25, Issue:4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Burkitt Lymphoma; Child; Combined Modality Therapy; Cytarabine; Dexamethasone; Etoposide; Humans; Immunotherapy; Leukemic Infiltration; Male; Meninges; Methotrexate; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Rituximab; Salvage Therapy; Testis; Topotecan; Transplantation, Autologous; Vindesine

2003
Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells.
    Nature genetics, 2003, Volume: 34, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Gene Expression; Gene Expression Profiling; Humans; Mercaptopurine; Methotrexate; Oligonucleotide Array Sequence Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

2003
Intrathecal methotrexate-induced acute cerebellar syndrome.
    Annals of hematology, 2003, Volume: 82, Issue:4

    Topics: Acute Disease; Adult; Antimetabolites, Antineoplastic; Cerebellar Diseases; Critical Care; Female; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2003
High-dose methotrexate: on the relationship of methotrexate elimination time vs renal function and serum methotrexate levels in 1164 courses in 264 Swedish children with acute lymphoblastic leukaemia (ALL).
    Cancer chemotherapy and pharmacology, 2003, Volume: 51, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Creatinine; Female; Humans; Infant; Kidney; Kidney Function Tests; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Urinalysis

2003
Imatinib Mesylate (Gleevec) is a useful agent in the salvage treatment of adults with relapsed/refractory Philadelphia positive acute leukemias.
    Hematology (Amsterdam, Netherlands), 2003, Volume: 8, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamides; Cytarabine; Daunorubicin; Doxorubicin; Enzyme Inhibitors; Female; Fusion Proteins, bcr-abl; Hepatitis B; Humans; Imatinib Mesylate; Immunosuppressive Agents; Lamivudine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Peripheral Blood Stem Cell Transplantation; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pyrimidines; Remission Induction; Salvage Therapy; Vincristine

2003
Transient encephalopathy following high-dose methotrexate.
    Medical and pediatric oncology, 2003, Volume: 41, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Diseases; Drug Administration Schedule; Female; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2003
[The influence of age, gender and modifications of therapeutic protocols on physical development of children and adolescents after completion of therapy for acute lymphoblastic leukemia].
    Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych, 2003, Volume: 9, Issue:1

    Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Mass Index; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Female; Growth; Humans; Longitudinal Studies; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Retrospective Studies; Risk Factors; Sex Factors; Thioguanine; Vincristine

2003
Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.
    International journal of oncology, 2003, Volume: 23, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Case-Control Studies; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Genes, MDR; Humans; Hydroxyurea; Male; Mercaptopurine; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Vincristine

2003
Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Aug-15, Volume: 21, Issue:16

    Topics: Carrier Proteins; Child; Homocysteine; Humans; Hyperhomocysteinemia; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2003
[Human leukocyte antigen mismatched hemopietic stem cell transplants for the treatment of leukemia].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2003, Apr-18, Volume: 35, Issue:2

    Topics: Bone Marrow Transplantation; Cyclophosphamide; Cyclosporine; Graft vs Host Disease; Granulocyte Colony-Stimulating Factor; Histocompatibility Antigens Class II; HLA Antigens; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Methotrexate; Mycophenolic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stem Cell Transplantation; Transplantation Conditioning; Transplantation, Homologous

2003
Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study.
    Journal of pediatric hematology/oncology, 2003, Volume: 25, Issue:9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Carrier Proteins; Child; Child, Preschool; Disease-Free Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Folate Receptors, GPI-Anchored; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Infant; Male; Methotrexate; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proliferating Cell Nuclear Antigen; Receptors, Cell Surface; Tetrahydrofolate Dehydrogenase

2003
Lymphoblastic lymphoma of childhood and the LSA2-L2 protocol: the 30-year experience at Memorial-Sloan-Kettering Cancer Center.
    Cancer, 2003, Sep-15, Volume: 98, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Disease-Free Survival; Female; Follow-Up Studies; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Radiotherapy Dosage; Survival Rate; Treatment Outcome; Vincristine

2003
SERUM COMPLEMENT LEVELS IN CHILDREN WITH ACUTE LYMPHOCYTIC LEUKEMIA.
    The Journal of pediatrics, 1964, Volume: 64

    Topics: Adolescent; Antineoplastic Agents; Blood; Child; Complement System Proteins; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Serologic Tests; Spectrophotometry; Thioguanine

1964
INTRACRANIAL EXTRACEREBRAL HEMORRHAGES IN ACUTE LYMPHOCYTIC LEUKEMIA. A PROBLEM RESULTING FROM THE CHEMOTHERAPEUTIC MODIFICATIONS OF ACUTE LEUKEMIA.
    Cancer, 1964, Volume: 17

    Topics: Adolescent; Child; Hematoma; Hematoma, Epidural, Cranial; Hematoma, Subdural; Humans; Hydrocephalus; Leucovorin; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Meninges; Mercaptopurine; Methotrexate; Pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiography; Subarachnoid Hemorrhage; Vinblastine

1964
Simultaneous determination of methotrexate and its eight metabolites in human whole blood by capillary zone electrophoresis.
    Journal of chromatography. A, 2003, Oct-03, Volume: 1014, Issue:1-2

    Topics: Antimetabolites, Antineoplastic; Electrophoresis, Capillary; Folic Acid Antagonists; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Sensitivity and Specificity

2003
Neurotoxicity of intrathecal methotrexate: MR imaging findings.
    AJNR. American journal of neuroradiology, 2003, Volume: 24, Issue:9

    Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Edema; Diffusion Magnetic Resonance Imaging; Female; Humans; Injections, Spinal; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2003
Bone marrow stroma damage induced by chemotherapy for acute lymphoblastic leukemia in children.
    Pediatric research, 2004, Volume: 55, Issue:1

    Topics: Antibodies; Antigens, CD34; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Child; Chronic Disease; Coculture Techniques; Cytokines; Erythroid Precursor Cells; Humans; Macrophage Inflammatory Proteins; Mercaptopurine; Methotrexate; Myeloid Progenitor Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stromal Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1

2004
White matter and cerebral metabolite changes in children undergoing treatment for acute lymphoblastic leukemia: longitudinal study with MR imaging and 1H MR spectroscopy.
    Radiology, 2003, Volume: 229, Issue:3

    Topics: Adolescent; Brain; Brain Chemistry; Child; Child, Preschool; Female; Humans; Infant; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

2003
Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia.
    Haematologica, 2003, Volume: 88, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Case-Control Studies; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Leukemic; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Protein Isoforms; Receptors, Glucocorticoid; Treatment Outcome; Vincristine

2003
Role of macrophages and stellate cells in the pathogenesis of veno-occlusive disease: an electron microscopic case study.
    Experimental and molecular pathology, 2003, Volume: 75, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Female; Hepatic Veno-Occlusive Disease; Humans; Liver; Macrophages; Mercaptopurine; Methotrexate; Microscopy, Electron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

2003
Pegylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukaemia in first remission: a pilot study.
    British journal of haematology, 2003, Volume: 123, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Blood Coagulation; Drug Administration Schedule; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction

2003
Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2003, Volume: 14, Issue:5

    Topics: Adolescent; Anaphylaxis; Anti-Allergic Agents; Antimetabolites, Antineoplastic; Antipruritics; Diphenhydramine; Dose-Response Relationship, Drug; Drug Eruptions; Drug Therapy, Combination; Histamine H2 Antagonists; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pruritus; Ranitidine; Skin Tests; Urticaria

2003
Impact of CNS treatment on mood in adult survivors of childhood leukemia: a report from the Children's Cancer Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Dec-01, Volume: 21, Issue:23

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Behavior; Brain Diseases; Case-Control Studies; Child; Cranial Irradiation; Female; Humans; Male; Methotrexate; Mood Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stress, Psychological; Surveys and Questionnaires; Survivors; Treatment Outcome

2003
Outcome of children with high-risk acute lymphoblastic leukemia (HR-ALL): Nordic results on an intensive regimen with restricted central nervous system irradiation.
    Pediatric blood & cancer, 2004, Volume: 42, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Stem Cell Transplantation; Transplantation, Homologous; Treatment Outcome

2004
CNS-directed therapy in young children with T-lineage acute lymphoblastic leukemia: High-dose methotrexate versus cranial irradiation.
    Pediatric blood & cancer, 2004, Volume: 42, Issue:1

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child, Preschool; Cohort Studies; Cranial Irradiation; Female; Humans; Infant; Leukemia, T-Cell; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate

2004
Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies.
    Blood, 2004, May-15, Volume: 103, Issue:10

    Topics: Adolescent; Animals; Antineoplastic Agents; Child; Child, Preschool; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Gene Rearrangement, T-Lymphocyte; Genes, Immunoglobulin; Humans; Immunophenotyping; Male; Methotrexate; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Heterologous; Treatment Outcome; Vincristine

2004
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
    Cancer, 2004, Feb-15, Volume: 100, Issue:4

    Topics: Antimetabolites, Antineoplastic; Blotting, Northern; Carrier Proteins; Child; DNA Mutational Analysis; Drug Resistance, Neoplasm; Humans; Membrane Transport Proteins; Methotrexate; Osteosarcoma; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Tumor Cells, Cultured

2004
Neurotoxicity marker profiles in the CSF are not age-dependent but show variation in children treated for acute lymphoblastic leukemia.
    Neurotoxicology, 2004, Volume: 25, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Chi-Square Distribution; Child; Child, Preschool; Female; Humans; Infant; Linear Models; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Statistics, Nonparametric; tau Proteins

2004
Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen.
    Cancer, 2004, Mar-15, Volume: 100, Issue:6

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Hyperglycemia; Infections; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors; Vincristine

2004
Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity.
    Clinical pharmacology and therapeutics, 2004, Volume: 75, Issue:4

    Topics: Alanine Transaminase; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Activation; Female; Humans; Liver; Liver Function Tests; Male; Maximum Tolerated Dose; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Probability; Risk Assessment; Severity of Illness Index

2004
Isolated central nervous system relapse in lymphoid blast crisis chronic myeloid leukemia and acute lymphoblastic leukemia in patients on imatinib therapy.
    Leukemia & lymphoma, 2004, Volume: 45, Issue:2

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Benzamides; Blast Crisis; Bone Marrow; Central Nervous System Neoplasms; Cytarabine; Female; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methotrexate; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recurrence; Remission Induction

2004
Late-onset delayed excretion of methotrexate.
    Cancer chemotherapy and pharmacology, 2004, Volume: 54, Issue:2

    Topics: Adolescent; Antimetabolites, Antineoplastic; Ascites; Humans; Male; Methotrexate; Pleural Effusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency

2004
Methotrexate-induced leukoencephalopathy reversed by aminophylline and high-dose folinic acid.
    Acta haematologica, 2004, Volume: 111, Issue:4

    Topics: Adult; Aminophylline; Brain Diseases; Female; Humans; Leucovorin; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2004
Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.
    Pharmacotherapy, 2004, Volume: 24, Issue:5

    Topics: Adult; Antimetabolites, Antineoplastic; Encephalomyelitis; Fatal Outcome; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2004
High-dose methotrexate and asparaginase for the treatment of children with acute lymphoblastic leukemia: why and how?
    Journal of pediatric hematology/oncology, 2004, Volume: 26, Issue:6

    Topics: Antineoplastic Agents; Asparaginase; Child; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2004
Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia: an unusual case marked by delayed perforation of the descending colon.
    Journal of pediatric surgery, 2004, Volume: 39, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Colostomy; Enterocolitis, Neutropenic; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Intestinal Perforation; Laparotomy; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Vincristine

2004
Prolonged fever of unknown origin and hemophagocytosis evolving into acute lymphoblastic leukemia.
    American journal of hematology, 2004, Volume: 76, Issue:4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Cytarabine; Disease Progression; Doxorubicin; Fever of Unknown Origin; Histiocytosis, Non-Langerhans-Cell; Humans; Karyotyping; Male; Methotrexate; Middle Aged; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Rituximab; Splenomegaly; Vincristine

2004
A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells.
    Pharmacogenetics, 2004, Volume: 14, Issue:8

    Topics: Catalysis; Cloning, Molecular; Diploidy; gamma-Glutamyl Hydrolase; Humans; Kinetics; Methotrexate; Mutagenesis, Site-Directed; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Substrate Specificity

2004
Primary acute lymphoblastic leukemia cells use a novel promoter and 5'noncoding exon for the human reduced folate carrier that encodes a modified carrier translated from an upstream translational start.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Aug-01, Volume: 10, Issue:15

    Topics: 5' Untranslated Regions; Base Sequence; Blotting, Northern; Blotting, Western; Cell Line, Tumor; DNA, Complementary; Exons; Gene Deletion; Genes, Reporter; Genotype; Humans; Jurkat Cells; K562 Cells; Kinetics; Luciferases; Membrane Transport Proteins; Methotrexate; Microscopy, Confocal; Models, Genetic; Molecular Sequence Data; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Protein Biosynthesis; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA Processing, Post-Transcriptional; RNA, Messenger; Time Factors; Transcription, Genetic

2004
Methotrexate inhibits the glyoxalase system in vivo in children with acute lymphoid leukaemia.
    European journal of cancer (Oxford, England : 1990), 2004, Volume: 40, Issue:15

    Topics: Antimetabolites, Antineoplastic; Child; Enzyme Inhibitors; Female; Humans; Lactoylglutathione Lyase; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2004
Pleomorphic adenoma of the lacrimal gland in a child after treatment of acute lymphoblastic leukemia.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2004, Volume: 122, Issue:10

    Topics: Adenoma, Pleomorphic; Adolescent; Antibiotics, Antineoplastic; Cyclophosphamide; Doxorubicin; Eye Neoplasms; Female; Humans; Immunosuppressive Agents; Lacrimal Apparatus; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2004
Unexpected response of hormone-refractory prostate cancer to treatment with an antileukemic chemotherapy regimen.
    Urology, 2004, Volume: 64, Issue:4

    Topics: Adenocarcinoma; Anilides; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Fatal Outcome; Goserelin; Humans; Immunocompromised Host; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Neoplasms, Second Primary; Neutropenia; Nitriles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostate-Specific Antigen; Prostatic Neoplasms; Recurrence; Sepsis; Tosyl Compounds; Vincristine

2004
Treatment of accidental intrathecal methotrexate overdose with intrathecal carboxypeptidase G2.
    Journal of the National Cancer Institute, 2004, Oct-20, Volume: 96, Issue:20

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Clinical Trials as Topic; Drainage; Drug Overdose; Female; gamma-Glutamyl Hydrolase; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Medication Errors; Methotrexate; Middle Aged; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins

2004
[Methotrexate-induced interstitial pneumonitis in a child with acute lymphoblastic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2004, Volume: 45, Issue:10

    Topics: Antimetabolites, Antineoplastic; Child, Preschool; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2004
[Mismatched hematopoietic stem cell transplantation using GIAC protocol: report of 100 cases].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2004, Volume: 25, Issue:8

    Topics: Adolescent; Adult; Antilymphocyte Serum; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Female; Graft vs Host Disease; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Histocompatibility Testing; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Homologous

2004
Improving the segmentation of therapy-induced leukoencephalopathy in children with acute lymphoblastic leukemia using a priori information and a gradient magnitude threshold.
    Magnetic resonance in medicine, 2004, Volume: 52, Issue:6

    Topics: Adolescent; Algorithms; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2004
The analysis of correlations between drug resistance and clinical/laboratory measures found in a group of children with all treated by ALL-BFM 90 protocol.
    Bulletin du cancer, 2004, Volume: 91, Issue:4

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Coloring Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Resistance, Neoplasm; Female; Humans; In Vitro Techniques; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Remission Induction; Sex Factors; Tetrazolium Salts; Thiazoles; Vincristine

2004
[Primary study of relationship between serum level of VEGF and non-Hodgkin's lymphoma in children and adolescent patients].
    Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:11 Suppl

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vascular Endothelial Growth Factor A; Vincristine

2004
Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia.
    Biological research for nursing, 2005, Volume: 6, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Injections, Spinal; Lipid Peroxidation; Male; Methotrexate; Oxidative Stress; Phosphatidylcholines; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
[Efficacy of modified BFM-90 regimen on children and adolescents with T cell lymphoblastic lymphoma: a report of 20 cases].
    Ai zheng = Aizheng = Chinese journal of cancer, 2004, Volume: 23, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Follow-Up Studies; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Stem Cell Transplantation; Survival Rate; Treatment Outcome; Vincristine

2004
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.
    The Journal of clinical investigation, 2005, Volume: 115, Issue:1

    Topics: Cluster Analysis; DNA; Folic Acid; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Leukocyte Count; Lymphocytes; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Messenger; Thymidylate Synthase

2005
[Immunologic monitoring in children with acute lymphoblastic leukemia during maintenance treatment with regard to co-existing infections].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2004, Volume: 57, Issue:7-8

    Topics: Adolescent; Antigens; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Flow Cytometry; Humans; Immunoglobulins; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Monitoring, Immunologic; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Statistics, Nonparametric; Thioguanine; Time Factors; Vincristine

2004
Images in haematology. Combined central retinal artery and vein occlusions as the presenting signs of ocular relapse in acute lymphoblastic leukaemia.
    British journal of haematology, 2005, Volume: 128, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Leukemic Infiltration; Methotrexate; Middle Aged; Ophthalmoscopy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retinal Artery Occlusion; Retinal Vein Occlusion

2005
[Treatment results in children with standard-risk acute lymphoblastic leukemia. Report of the Polish Pediatric Leukemia/Lymphoma Study Group].
    Przeglad lekarski, 2004, Volume: 61 Suppl 2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Bone Neoplasms; Central Nervous System Neoplasms; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Infant, Newborn; Male; Mercaptopurine; Methotrexate; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Retrospective Studies; Risk Factors; Secondary Prevention; Survival Analysis; Testicular Neoplasms; Time Factors; Treatment Outcome; Vincristine

2004
Interference of 7-hydroxymethotrexate with the determination of methotrexate in plasma samples from children with acute lymphoblastic leukemia employing routine clinical assays.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Mar-25, Volume: 817, Issue:2

    Topics: Child; Chromatography, High Pressure Liquid; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet

2005
Second induction in pediatric patients with recurrent acute lymphoid leukemia using DFCI-ALL protocols.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Doxorubicin; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Retrospective Studies; Stem Cell Transplantation; Survival Analysis; Transplantation, Homologous; Treatment Outcome; Vincristine

2005
Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects.
    European journal of cancer (Oxford, England : 1990), 2005, Volume: 41, Issue:4

    Topics: Child; Child, Preschool; Female; Folic Acid Antagonists; Genotype; Humans; Male; Methotrexate; Methyltransferases; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Trimethoprim

2005
Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia.
    Cancer research, 2005, Mar-15, Volume: 65, Issue:6

    Topics: Alleles; Antimetabolites, Antineoplastic; Case-Control Studies; Child, Preschool; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Cognitive changes in children treated for acute lymphoblastic leukemia with chemotherapy only according to the Pediatric Oncology Group 9605 protocol.
    Journal of child neurology, 2005, Volume: 20, Issue:2

    Topics: Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Cognition Disorders; Cohort Studies; Cytarabine; Female; Hematinics; Humans; Hydrocortisone; Leucovorin; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Wechsler Scales

2005
Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia.
    Blood, 2005, Jul-15, Volume: 106, Issue:2

    Topics: Antimetabolites, Antineoplastic; Child; Drug Resistance, Neoplasm; Ferredoxin-NADP Reductase; Folic Acid; Genetic Variation; Glycine Hydroxymethyltransferase; Humans; In Vitro Techniques; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Effects and interaction of 7-hydroxy methotrexate and methotrexate in leukaemic cells ex vivo measured by the thymidylate synthase inhibition assay.
    Cancer chemotherapy and pharmacology, 2005, Volume: 56, Issue:3

    Topics: Antimetabolites, Antineoplastic; Drug Interactions; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase; Tumor Cells, Cultured

2005
Kernohan notch lesion after spinal tap.
    Neurology, 2005, May-10, Volume: 64, Issue:9

    Topics: Adult; Causality; Cerebral Veins; Disease Progression; Efferent Pathways; Female; Headache; Hematoma, Subdural, Intracranial; Hemiplegia; Humans; Injections, Spinal; Intracranial Hypotension; Magnetic Resonance Imaging; Mesencephalon; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Puncture; Thrombocytopenia

2005
Myelopathy due to intrathecal chemotherapy: report of six cases.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:5

    Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Folic Acid Antagonists; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases

2005
[Leucovorin rescue after continuing infusion of high dose methotrexate].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2005, Volume: 43, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Transient encephalopathy after intrathekal methotrexate chemotherapy: diffusion-weighted MRI.
    Journal of neuro-oncology, 2005, Volume: 73, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child; Diffusion Magnetic Resonance Imaging; Humans; Injections, Spinal; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome

2005
[Study on elimination delay in high dose methotrexate therapy in childhood acute lymphoblastic leukemia].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2005, Volume: 26, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Nausea; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Treatment Outcome; Vomiting; Young Adult

2005
Nuclear winter.
    Transfusion, 2005, Volume: 45, Issue:9

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Child, Preschool; Humans; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate.
    Oncology, 2005, Volume: 69, Issue:3

    Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases, Metabolic; Child; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Pharmacodynamic properties of methotrexate and Aminotrexate during weekly therapy.
    Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:6

    Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Folic Acid Antagonists; Humans; Infant; Male; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tissue Distribution

2006
Central nervous system chemoprophylaxis in non-Hodgkin lymphoma: current practice in the UK.
    British journal of haematology, 2005, Volume: 131, Issue:2

    Topics: Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Neoplasms; Chemoprevention; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Patient Selection; Practice Patterns, Physicians'; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Surveys and Questionnaires; United Kingdom

2005
A quantitative MR imaging assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation.
    AJNR. American journal of neuroradiology, 2005, Volume: 26, Issue:9

    Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child; Child, Preschool; Humans; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Brain white matter changes during treatment of a child for acute lymphoblastic leukemia.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2005, Volume: 72, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2007, Volume: 48, Issue:3

    Topics: AC133 Antigen; Amphotericin B; Antifungal Agents; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Caspofungin; Child; Combined Modality Therapy; Contraindications; Dexamethasone; Drug Therapy, Combination; Echinocandins; Glycoproteins; Humans; Immunomagnetic Separation; Lipopeptides; Male; Mercaptopurine; Methotrexate; Peptides; Peptides, Cyclic; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recurrence; Remission Induction; Salvage Therapy; Transplantation, Autologous; Transplantation, Homologous; Triazoles; Vincristine; Voriconazole; Zygomycosis

2007
Whole brain magnetization transfer histogram analysis of pediatric acute lymphoblastic leukemia patients receiving intrathecal methotrexate therapy.
    European journal of radiology, 2006, Volume: 57, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child; Child, Preschool; Feasibility Studies; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

2006
Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin.
    Journal of neurology, 2005, Volume: 252, Issue:11

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Humans; Immunoglobulins, Intravenous; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pseudobulbar Palsy; Radiography

2005
p16 inactivation associated with aggressive clinical course and fatal outcome in TEL/AML1-positive acute lymphoblastic leukemia.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Chromosomes, Human, Pair 9; Combined Modality Therapy; Core Binding Factor Alpha 2 Subunit; Cyclin-Dependent Kinase Inhibitor p16; Cyclophosphamide; Cytarabine; Daunorubicin; Fatal Outcome; Gene Deletion; Genes, p16; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Proteins; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Vincristine

2005
Reversible acute methotrexate leukoencephalopathy: atypical brain MR imaging features.
    Pediatric radiology, 2006, Volume: 36, Issue:3

    Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Child, Preschool; Contrast Media; Female; Humans; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2006
Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2006, Volume: 46, Issue:7

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Erythrocytes; Female; Humans; Liver Cirrhosis; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Statistics, Nonparametric

2006
Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials.
    Pediatric blood & cancer, 2007, Volume: 48, Issue:3

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Etoposide; Female; Humans; Male; Mercaptopurine; Methotrexate; Patient Selection; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Randomized Controlled Trials as Topic; Remission Induction; Research Design; Survival Analysis; Thioguanine; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome; Vincristine

2007
The old grey mare, she ain't what she used to be. Is she?: (commentary on Kaspers et al., page 539).
    Pediatric blood & cancer, 2006, Oct-15, Volume: 47, Issue:5

    Topics: Child; Clinical Trials, Phase II as Topic; Drug Resistance, Neoplasm; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recurrence; Treatment Failure; Treatment Outcome

2006
Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited.
    Clinical chemistry, 2006, Volume: 52, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12; Vitamin B Complex

2006
Polyuria associated with high-dose methotrexate in two patients with acute lymphoblastic leukaemia.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2005, Volume: 11, Issue:1

    Topics: Adenosine; Adolescent; Antimetabolites, Antineoplastic; Child; Diabetes Insipidus, Nephrogenic; Female; Fluid Therapy; Humans; Injections, Intravenous; Male; Methotrexate; Polyuria; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2005
Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma.
    Journal of pediatric hematology/oncology, 2006, Volume: 28, Issue:2

    Topics: Adolescent; Alleles; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genetic Variation; Hematologic Diseases; Humans; Infant; Japan; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Stomatitis

2006
bcr-abl-positive T-cell acute lymphoblastic leukemia associated with parvovirus B19 infection.
    Journal of pediatric hematology/oncology, 2006, Volume: 28, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Cerebral Hemorrhage; Combined Modality Therapy; Disseminated Intravascular Coagulation; Fatal Outcome; Fusion Proteins, bcr-abl; Genes, abl; Hematopoietic Stem Cell Transplantation; Humans; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Multiple Organ Failure; Neoplasm Proteins; Pancytopenia; Parvoviridae Infections; Parvovirus B19, Human; Philadelphia Chromosome; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Preleukemia; Shock, Septic; Staphylococcal Infections; Vincristine

2006
Roles of protein C, protein S, and antithrombin III in acute leukemia.
    American journal of hematology, 2006, Volume: 81, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Antithrombin III; Asparaginase; Cyclophosphamide; Cytarabine; Disseminated Intravascular Coagulation; Female; Humans; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Myocardial Infarction; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Protein C; Protein S; Thrombosis; Vincristine

2006
Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR-ABL--positive acute lymphoblastic leukemia-retrospective analysis of Polish Adult Leukemia Group (PALG).
    Annals of hematology, 2006, Volume: 85, Issue:6

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Disease-Free Survival; Female; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mercaptopurine; Methotrexate; Middle Aged; Philadelphia Chromosome; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Treatment Outcome

2006
MR imaging of the brain in patients cured of acute lymphoblastic leukemia--the value of gradient echo imaging.
    AJNR. American journal of neuroradiology, 2006, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Brain; Child; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction

2006
5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism.
    Cancer research, 2006, Apr-01, Volume: 66, Issue:7

    Topics: Aminoimidazole Carboxamide; Biological Transport; Cell Line, Tumor; Child; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid Antagonists; Humans; Kinetics; Leukemia, T-Cell; Membrane Transport Proteins; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Ribonucleotides; Subcellular Fractions; Temperature; Thymidylate Synthase; Tritium

2006
Occurrence and impact of unanticipated variation in intravenous methotrexate dosing.
    The Annals of pharmacotherapy, 2006, Volume: 40, Issue:5

    Topics: Antimetabolites, Antineoplastic; Child; Humans; Infusions, Intravenous; Medication Errors; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

2006
Central nervous system recurrence in adult patients with acute lymphoblastic leukemia: frequency and prognosis in 467 patients without cranial irradiation for prophylaxis.
    Cancer, 2006, Jun-15, Volume: 106, Issue:12

    Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Humans; Hydrocortisone; Incidence; Lactate Dehydrogenases; Male; Methotrexate; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; Survival Analysis

2006
[Neurological complications during and after the treatment of acute lymphocytic leukemia].
    No to hattatsu = Brain and development, 2006, Volume: 38, Issue:3

    Topics: Adolescent; Antineoplastic Agents; Asparaginase; Cerebrovascular Disorders; Child; Child, Preschool; Cytarabine; Dementia, Vascular; Epilepsy; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Thiamine Deficiency; Wernicke Encephalopathy

2006
Solid-phase extraction and large-volume sample stacking with an electroosmotic flow pump in capillary electrophoresis for determination of methotrexate and its metabolites in human plasma.
    Electrophoresis, 2006, Volume: 27, Issue:14

    Topics: Antimetabolites, Antineoplastic; Buffers; Electrophoresis, Capillary; Humans; Infusion Pumps; Methotrexate; Monitoring, Physiologic; Phosphates; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2006
Acute lymphoblastic leukemia in adolescents between 10 and 19 years of age in Denmark--secondary publication.
    Danish medical bulletin, 2006, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Cyclophosphamide; Daunorubicin; Doxorubicin; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Retrospective Studies; Stem Cell Transplantation; Treatment Outcome; Vincristine

2006
[Acute lymphoblastic leukaemia in Danish children and young people 10 to 19 years of age. Should young adults with acute lymphoblastic leukaemia be treated in the same way as children?].
    Ugeskrift for laeger, 2006, Jun-26, Volume: 168, Issue:26-32

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Daunorubicin; Doxorubicin; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Stem Cell Transplantation; Treatment Outcome; Vincristine

2006
Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate.
    Magnetic resonance imaging, 2006, Volume: 24, Issue:6

    Topics: Adolescent; Algorithms; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Diagnosis, Computer-Assisted; Diagnosis, Differential; Female; Humans; Image Processing, Computer-Assisted; Infant; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2006
Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells.
    American journal of human genetics, 2006, Volume: 79, Issue:2

    Topics: Adolescent; Adult; Child; Child, Preschool; DNA Methylation; Enzyme Activation; Epigenesis, Genetic; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

2006
Reduction in bioavailability of 6-mercaptopurine on simultaneous administration with cow's milk.
    Pediatric hematology and oncology, 2006, Volume: 23, Issue:6

    Topics: Animals; Antineoplastic Agents; Biological Availability; Child, Preschool; Humans; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Milk; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2006
Folate cycle gene variants and chemotherapy toxicity in pediatric patients with acute lymphoblastic leukemia.
    Haematologica, 2006, Volume: 91, Issue:8

    Topics: Child; Disease-Free Survival; Folic Acid; Folic Acid Antagonists; Hematologic Diseases; Humans; Liver; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2006
[Treatment results in children with the standard risk acute lymphoblastic leukemia treated with high dose of methotrexate (5.0 g/m2). 11 years of the Polish Pediatric Leukemia/Lymphoma Study Group experience].
    Przeglad lekarski, 2006, Volume: 63, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cohort Studies; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Treatment Outcome

2006
[Acute lymphoblastic leukemia in children with initial leucocytosis above 50,000/mm3: summary of treatment results of Polish Pediatric Leukemia/Lymphoma Study Group].
    Przeglad lekarski, 2006, Volume: 63, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Infant; Leukocyte Count; Leukocytosis; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Thioguanine; Treatment Outcome; Vincristine

2006
Physical activity during treatment in children with leukemia: a pilot study.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2006, Volume: 31, Issue:4

    Topics: Antineoplastic Agents; Child; Child, Preschool; Exercise; Female; Humans; Male; Mercaptopurine; Methotrexate; Motor Activity; Oxygen Consumption; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

2006
Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia.
    Cancer, 2006, Sep-15, Volume: 107, Issue:6

    Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Dexamethasone; Humans; Infant; Medication Errors; Mercaptopurine; Methotrexate; Outpatients; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Thioguanine

2006
Prevention of oral lesions in children with acute lymphoblastic leukemia.
    International journal of pediatric otorhinolaryngology, 2006, Volume: 70, Issue:11

    Topics: Adolescent; Anti-Infective Agents; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Chlorhexidine; Female; Humans; Male; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis

2006
Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Aug-20, Volume: 24, Issue:24

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Attention; Brain Neoplasms; Child, Preschool; Cognition; Cohort Studies; Cranial Irradiation; Dose Fractionation, Radiation; Educational Status; Female; Humans; Infant; Infusions, Intravenous; Intelligence Tests; Male; Memory; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2006
[Twenty years of treating childhood acute lymphoblastic leukemia].
    Anales de pediatria (Barcelona, Spain : 2003), 2006, Volume: 65, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Etoposide; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Prognosis; Recurrence; Risk Factors; Survival Rate; Time Factors; Vincristine

2006
High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia.
    Leukemia, 2006, Volume: 20, Issue:11

    Topics: Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Disease-Free Survival; Drug Interactions; Female; Humans; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Registries; Risk Factors; Secondary Prevention; Vitamin B Complex

2006
Therapeutic responses in childhood acute lymphoblastic leukemia (ALL) and haplotypes of gamma glutamyl hydrolase (GGH) gene.
    Leukemia research, 2007, Volume: 31, Issue:7

    Topics: gamma-Glutamyl Hydrolase; Haplotypes; Humans; Methotrexate; Polyglutamic Acid; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Disseminated necrotizing leukoencephalopathy following chemoradiation therapy for acute lymphoblastic leukemia.
    Radiation medicine, 2006, Volume: 24, Issue:7

    Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Necrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

2006
DHFR and MSH3 co-amplification in childhood acute lymphoblastic leukaemia, in vitro and in vivo.
    Carcinogenesis, 2007, Volume: 28, Issue:6

    Topics: Cell Line, Transformed; Cell Line, Tumor; Child; DNA-Binding Proteins; Gene Amplification; Gene Dosage; Humans; Methotrexate; MutS Homolog 3 Protein; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase

2007
Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia?
    Leukemia & lymphoma, 2006, Volume: 47, Issue:12

    Topics: Central Nervous System; Central Nervous System Neoplasms; Child; Clinical Trials as Topic; Humans; Leucovorin; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recurrence; Risk

2006
Dermal dendrocyte ballooning.
    American journal of clinical dermatology, 2006, Volume: 7, Issue:6

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dendritic Cells; Drug Eruptions; Humans; Keratinocytes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin

2006
Reduced elimination of Methotrexate in an adult with trisomy 21 and acute lymphoblastic leukaemia.
    Leukemia research, 2007, Volume: 31, Issue:10

    Topics: Adult; Antimetabolites, Antineoplastic; Down Syndrome; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma.
    Journal of human genetics, 2007, Volume: 52, Issue:2

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genotype; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Infant; Liver Diseases; Lymphoma; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

2007
Ultraviolet recall reaction after total body irradiation, etoposide, and methotrexate therapy.
    Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Etoposide; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Skin; Sunburn; Ultraviolet Rays; Whole-Body Irradiation

2007
A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 2007, Volume: 60, Issue:4

    Topics: Adolescent; Bayes Theorem; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Models, Theoretical; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sampling Studies

2007
Myelopathy due to intrathecal chemotherapy: magnetic resonance imaging findings.
    Clinical radiology, 2007, Volume: 62, Issue:2

    Topics: Adult; Antimetabolites, Antineoplastic; Cytarabine; Female; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord; Spinal Cord Diseases

2007
[Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2006, Volume: 47, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Doxorubicin; Facial Paralysis; Humans; Injections, Spinal; Male; Methotrexate; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Risk Factors; Sagittal Sinus Thrombosis; Vincristine

2006
Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Jan-15, Volume: 13, Issue:2 Pt 1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biological Transport; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Female; Gene Expression Regulation, Neoplastic; Humans; Infant; Male; Membrane Transport Proteins; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2007
Ancestry and pharmacogenetics of antileukemic drug toxicity.
    Blood, 2007, May-15, Volume: 109, Issue:10

    Topics: Antineoplastic Agents; Child; Drug-Related Side Effects and Adverse Reactions; Genotype; Humans; Methotrexate; Models, Biological; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Racial Groups; Remission Induction

2007
[Reults of treatment with protocols BFM 90 and BFM 95].
    Medicinski arhiv, 2006, Volume: 60, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Survival Rate; Vincristine

2006
Transverse myelopathy following intrathecal administration of chemotherapy.
    Singapore medical journal, 2007, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fatal Outcome; Hodgkin Disease; Humans; Injections, Spinal; Leukemic Infiltration; Male; Methotrexate; Myelitis, Transverse; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Comparison of long-term neurocognitive outcomes in young children with acute lymphatic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Feb-20, Volume: 25, Issue:6

    Topics: Child; Child, Preschool; Cognition; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Incidence; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Risk Assessment; Time Factors

2007
Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia.
    Annals of hematology, 2007, Volume: 86, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Folic Acid Antagonists; Humans; Infant; Male; Methotrexate; Methyltransferases; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia.
    Leukemia, 2007, Volume: 21, Issue:5

    Topics: Adolescent; B-Lymphocytes; Blast Crisis; CD11b Antigen; Cell Cycle; Cell Proliferation; Child; Child, Preschool; Female; Gene Expression Profiling; Humans; Infant; Interferon gamma Receptor; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Receptors, Interferon

2007
[The clinical features of B cell lymphoblastic lymphoma and outcomes after BFM-90 regimen therapy].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2006, Volume: 27, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Lymphoma, B-Cell; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2006
[High dose methotrexate induced acute renal insufficiency in a patient with acute lymphoblastic leukemia].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2007, Volume: 45, Issue:1

    Topics: Acute Kidney Injury; Child; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia.
    Leukemia research, 2008, Volume: 32, Issue:1

    Topics: Adult; Child; Child, Preschool; Drug Resistance, Neoplasm; Ethnicity; Female; Genetic Predisposition to Disease; Humans; Indonesia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Netherlands; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Tandem Repeat Sequences; Thymidylate Synthase

2008
Obesity in survivors of childhood acute lymphoblastic leukemia and lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Apr-01, Volume: 25, Issue:10

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Body Mass Index; Child; Child, Preschool; Cranial Irradiation; Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Methotrexate; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2007
[Complications in the central nervous system during chemotherapy for childhood acute lymphoblastic leukemia: JACLS ALL-02 study].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2007, Volume: 48, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Japan; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors

2007
Triple intrathecal therapy without cranial irradiation for central nervous system preventive therapy in childhood acute lymphoblastic leukemia.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System; Child; Child, Preschool; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Epirubicin; Female; Follow-Up Studies; Humans; Hydrocortisone; Infant; Injections, Spinal; Leukemic Infiltration; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Retrospective Studies; Risk; Survival Analysis; Vincristine

2008
What is the best salvage therapy for treatment of isolated CNS relapse in elderly patients with imatinib-responsive Ph(+) ALL?
    Leukemia research, 2007, Volume: 31, Issue:10

    Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bone Marrow; Cytarabine; Humans; Hydrocortisone; Imatinib Mesylate; Injections, Spinal; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Radiotherapy; Salvage Therapy

2007
Allogeneic bone marrow transplantation with total body irradiation-based conditioning in acute lymphoblastic leukemia patient with Cochlear implant.
    Annals of transplantation, 2006, Volume: 11, Issue:2

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow Transplantation; Cochlear Implantation; Cyclosporine; Follow-Up Studies; Graft vs Host Disease; Humans; Immunosuppressive Agents; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Time Factors; Transplantation, Homologous; Treatment Outcome; Whole-Body Irradiation

2006
MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients.
    Leukemia research, 2007, Volume: 31, Issue:12

    Topics: Adolescent; Adult; Aged; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Rate; Treatment Outcome

2007
Motor and perceptual timing deficits among survivors of childhood leukemia.
    Journal of pediatric psychology, 2007, Volume: 32, Issue:8

    Topics: Adult; Antimetabolites, Antineoplastic; Cerebellum; Child; Female; Frontal Lobe; Humans; Judgment; Male; Methotrexate; Motor Skills Disorders; Perceptual Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reaction Time; Survivors

2007
Allogeneic transplantation for adult acute leukemia in first and second remission with a novel regimen incorporating daily intravenous busulfan, fludarabine, 400 CGY total-body irradiation, and thymoglobulin.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2007, Volume: 13, Issue:7

    Topics: Adolescent; Adult; Antibodies, Monoclonal; Antilymphocyte Serum; Antineoplastic Agents; Busulfan; Cyclosporine; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Infusions, Intravenous; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Myeloablative Agonists; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Stem Cell Transplantation; Survival Rate; Transplantation Conditioning; Transplantation, Homologous; Vidarabine; Whole-Body Irradiation

2007
Biphenotypic acute leukaemia: a case series.
    British journal of haematology, 2007, Volume: 138, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Immunophenotyping; Leukemia; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Vincristine

2007
A 'pre-induction course' with non-cross-reacting cytostatic drugs for rapid tumour load reduction improves outcome in adult acute lymphoblastic leukaemia.
    British journal of haematology, 2007, Volume: 138, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Cytarabine; Drug Therapy, Combination; Etoposide; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Tumor Burden

2007
Vincristine-induced acute neurotoxicity versus Guillain-Barré syndrome: a diagnostic dilemma.
    European journal of neurology, 2007, Volume: 14, Issue:7

    Topics: Action Potentials; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Dexamethasone; Diagnosis, Differential; Erectile Dysfunction; Fatal Outcome; Guillain-Barre Syndrome; Humans; Hydrocortisone; Male; Methotrexate; Paraparesis; Paresthesia; Polyradiculoneuropathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Urination Disorders; Vincristine

2007
Induction of acute lymphocytic leukemia differentiation by maintenance therapy.
    Leukemia, 2007, Volume: 21, Issue:9

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Clone Cells; Cytotoxins; Hematopoietic Stem Cells; Humans; Immunophenotyping; In Vitro Techniques; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Tretinoin

2007
Disseminated intravascular coagulation in acute leukemia at presentation and during induction therapy.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2007, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Disseminated Intravascular Coagulation; Female; Humans; Incidence; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Partial Thromboplastin Time; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Vincristine

2007
A paediatric case of Candida pericarditis and eosophagus stricture during treatment for acute lymphatic leukaemia.
    Acta oncologica (Stockholm, Sweden), 2007, Volume: 46, Issue:6

    Topics: Antineoplastic Agents; Candida albicans; Candidiasis; Child, Preschool; Doxorubicin; Esophageal Stenosis; Female; Humans; Immunosuppression Therapy; Methotrexate; Pericarditis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Risk Factors; Vincristine

2007
A step forward in therapy for ALL in infants.
    Lancet (London, England), 2007, Jul-21, Volume: 370, Issue:9583

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Infant; Infant, Newborn; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Randomized Controlled Trials as Topic

2007
Methotrexate concentrations in cerebrospinal fluid and serum, and the risk of central nervous system relapse in children with acute lymphoblastic leukaemia.
    Anti-cancer drugs, 2007, Volume: 18, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Logistic Models; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk

2007
Re: Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia.
    Blood, 2007, Sep-01, Volume: 110, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Encephalitis; Female; Humans; Injections, Spinal; Leukemic Infiltration; Liposomes; Male; Meninges; Meningitis; Methotrexate; Middle Aged; Papilledema; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures

2007
L'asparaginase and methotrexate combinations: clashes of empiric success and laboratory models?
    Journal of pediatric hematology/oncology, 2007, Volume: 29, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Drug Synergism; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico.
    Hematology (Amsterdam, Netherlands), 2007, Volume: 12, Issue:5

    Topics: Adolescent; Adult; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Diet; Female; Folic Acid; Humans; Infant; Infant, Newborn; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Mucositis; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

2007
pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia.
    Medicina oral, patologia oral y cirugia bucal, 2007, Oct-01, Volume: 12, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Clinical Protocols; Humans; Hydrogen-Ion Concentration; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Sodium Bicarbonate

2007
Lipomembranous panniculitis in a patient with acute leukemia induced by chemotherapy.
    Leukemia research, 2008, Volume: 32, Issue:4

    Topics: Adipose Tissue; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Fat Necrosis; Female; Humans; Methotrexate; Panniculitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2008
Retrospective study on elimination delay of methotrexate in high-dose therapy of childhood acute lymphoblastic leukemia in China.
    Journal of pediatric hematology/oncology, 2007, Volume: 29, Issue:10

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Female; Fluid Therapy; Humans; Infant; Infusions, Intravenous; Liver; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2007
Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:1

    Topics: Acute Disease; Adolescent; Aminophylline; Antimetabolites, Antineoplastic; Bone Neoplasms; Brain; Child; Diffusion Magnetic Resonance Imaging; Female; Histiocytoma, Malignant Fibrous; Humans; Injections, Intravenous; Injections, Spinal; Leukemia; Male; Metabolic Clearance Rate; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

2008
Anterior lumbosacral polyradiculopathy after intrathecal administration of methotrexate.
    Journal of the neurological sciences, 2008, Apr-15, Volume: 267, Issue:1-2

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Interactions; Fatal Outcome; Humans; Hydrocortisone; Injections, Spinal; Leg; Lumbosacral Plexus; Male; Methotrexate; Motor Neurons; Muscle, Skeletal; Neural Conduction; Paralysis; Paraparesis; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Respiratory Tract Infections; Sepsis; Spinal Nerve Roots; Urinary Bladder, Neurogenic

2008
Neurochemical markers of brain damage in cerebrospinal fluid during induction treatment of acute lymphoblastic leukemia in children.
    Pediatric blood & cancer, 2008, Volume: 50, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers; Brain; Brain Damage, Chronic; Brain Injuries; Child; Child, Preschool; Dehydroascorbic Acid; Female; Glial Fibrillary Acidic Protein; Humans; Infant; Male; Methotrexate; Neurofilament Proteins; Phosphopyruvate Hydratase; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radioimmunoassay

2008
Cytarabine induced noncardiogenic pulmonary edema in a case of acute lymphoblastic leukemia.
    International journal of laboratory hematology, 2007, Volume: 29, Issue:6

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Glucocorticoids; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Edema; Radiography; Vincristine

2007
[Pharmacogenomics of acute lymphoblastic leukemia].
    Medecine sciences : M/S, 2007, Volume: 23, Issue:11

    Topics: Antineoplastic Agents; Humans; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
High-performance liquid chromatography separation of aminopterin-polyglutamates within red blood cells of children treated for acute lymphoblastic leukemia.
    Translational research : the journal of laboratory and clinical medicine, 2007, Volume: 150, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Aminopterin; Antineoplastic Agents; Child; Child, Preschool; Chromatography, High Pressure Liquid; Erythrocytes; Folic Acid Antagonists; Humans; Infant; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Standards; Tissue Distribution

2007
Genetic and epigenetic alterations of the reduced folate carrier in untreated diffuse large B-cell lymphoma.
    European journal of haematology, 2008, Volume: 80, Issue:1

    Topics: Adolescent; Adult; Biopsy; Child; Child, Preschool; Codon, Nonsense; DNA Methylation; DNA Mutational Analysis; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Mutation; Mutation, Missense; Point Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein

2008
Atypical acute graft-versus-host disease.
    The American Journal of dermatopathology, 2007, Volume: 29, Issue:6

    Topics: Acute Disease; Adult; Bone Marrow Transplantation; Cyclosporine; Erythema; Graft vs Host Disease; Humans; Immunosuppressive Agents; Male; Methotrexate; Necrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Diseases; Treatment Outcome

2007
Successful high-dose methotrexate chemotherapy in a patient with acute lymphocytic leukemia who developed acute renal failure during the initial treatment.
    Pediatrics international : official journal of the Japan Pediatric Society, 2007, Volume: 49, Issue:6

    Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Female; Humans; Infant; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2007
Bronchial asthma and acute lymphoblastic leukemia in childhood.
    Pediatric pulmonology, 2008, Volume: 43, Issue:2

    Topics: Acute Disease; Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Asthma; Drug Administration Schedule; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2008
DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL.
    Blood, 2008, Apr-01, Volume: 111, Issue:7

    Topics: Alleles; Antimetabolites, Antineoplastic; Cyclin D; Cyclins; Disease-Free Survival; DNA, Neoplasm; Female; Folic Acid; Haplotypes; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Survival Rate; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transcription, Genetic

2008
Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors.
    The Journal of pediatrics, 2008, Volume: 152, Issue:1

    Topics: Adult; Antimetabolites, Antineoplastic; Attention Deficit Disorder with Hyperactivity; Child; Female; Folic Acid Antagonists; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NAD+); Parents; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Surveys and Questionnaires; Survivors

2008
Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity.
    Journal of the neurological sciences, 2008, Jun-15, Volume: 269, Issue:1-2

    Topics: Adult; Brain Diseases; Diffusion Magnetic Resonance Imaging; Humans; Immunosuppressive Agents; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2008
[Accretion of bone mass in patients treated for childhood acute lymphoblastic leukemia].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2007, Volume: 23, Issue:136

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Case-Control Studies; Child; Child, Preschool; Cranial Irradiation; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2007
[Population pharmacokinetics of high-dose methotrexate administered in 329 children with acute lymphoblastic leukemia].
    Zhongguo shi yan xue ye xue za zhi, 2008, Volume: 16, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Models, Biological; Nonlinear Dynamics; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2008
Polymorphisms in folate-related genes: association with side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia.
    Leukemia, 2008, Volume: 22, Issue:9

    Topics: Child; DNA Mutational Analysis; Folic Acid; Gene Frequency; Genotype; Humans; Metabolic Networks and Pathways; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2008
Interaction between methotrexate and omeprazole in an adolescent with leukemia: a case report.
    Pharmacy world & science : PWS, 2008, Volume: 30, Issue:4

    Topics: Adolescent; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Humans; Male; Methotrexate; Omeprazole; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Ranitidine; Stomach Ulcer

2008
Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia.
    Biological research for nursing, 2008, Volume: 9, Issue:4

    Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Child; Chromatography, Gas; Cognition Disorders; Female; Humans; Intelligence Tests; Male; Methotrexate; NAD; Oxidation-Reduction; Palmitic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Risk Factors; Statistics, Nonparametric; Stearic Acids

2008
In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.
    PLoS medicine, 2008, Apr-15, Volume: 5, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cohort Studies; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Infant; Kaplan-Meier Estimate; Male; Methotrexate; Neoplastic Cells, Circulating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2008
Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in children with cancer.
    European journal of cancer care, 2008, Volume: 17, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Nausea; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Vomiting

2008
Use of palifermin for the prevention of high-dose methotrexate-induced oral mucositis.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fibroblast Growth Factor 7; Follow-Up Studies; Humans; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Pain Measurement; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Values; Retrospective Studies; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Stomatitis; Treatment Outcome

2008
Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma.
    Journal of pediatric hematology/oncology, 2008, Volume: 30, Issue:5

    Topics: Adolescent; Antineoplastic Agents; Carbon-Nitrogen Ligases; Child; Child, Preschool; Genotype; Humans; Mercaptopurine; Methotrexate; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

2008
Intravenous immunoglobulin in the treatment of severe methotrexate-induced acral erythema.
    Journal of pediatric hematology/oncology, 2008, Volume: 30, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Diagnosis, Differential; Erythema; Foot Diseases; Hand Dermatoses; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2008
Treatment of high-risk acute lymphoblastic leukemia in children using the AL851 and ALHR88 protocols: a report from the Kyushu-Yamaguchi Children's Cancer Study Group in Japan.
    Medical and pediatric oncology, 1996, Volume: 26, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Vincristine

1996
Peripheral blood progenitor cell transplantation in lymphoma and leukemia using a single apheresis.
    Blood, 1993, Dec-15, Volume: 82, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Colony-Forming Units Assay; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Length of Stay; Leukapheresis; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Vincristine

1993
[Pulmonary mucormycosis in leukemic patients. Apropos of 2 cases].
    Sangre, 1994, Volume: 39, Issue:1

    Topics: Adult; Aged; Amphotericin B; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fatal Outcome; Granulocyte Colony-Stimulating Factor; Humans; Immunologic Factors; Itraconazole; Leukemia, Promyelocytic, Acute; Lung Diseases, Fungal; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Mucormycosis; Neutropenia; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1994
Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:2

    Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Erythrocytes; Female; Follow-Up Studies; Guanine Nucleotides; Humans; Infant; Male; Mercaptopurine; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Regression Analysis; Remission Induction; Risk; Thionucleotides; Time Factors

1995
Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin.
    Blood, 1995, May-01, Volume: 85, Issue:9

    Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; Blood-Brain Barrier; Bone Marrow; Cell Movement; Central Nervous System; DNA, Neoplasm; Drug Evaluation, Preclinical; Immunotoxins; Injections, Intraperitoneal; Injections, Intravenous; Injections, Spinal; Leukemic Infiltration; Meninges; Methotrexate; Mice; Mice, SCID; N-Glycosyl Hydrolases; Neoplasm Transplantation; Neoplastic Cells, Circulating; Plant Proteins; Polymerase Chain Reaction; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ribosome Inactivating Proteins, Type 1; Specific Pathogen-Free Organisms; Transplantation, Heterologous

1995
Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: implications for therapeutic management.
    Cancer letters, 1995, Aug-01, Volume: 94, Issue:2

    Topics: Adolescent; Bleomycin; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Iron; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies

1995
Acute lymphoblastic leukemia in the elderly: results of two different treatment approaches in 49 patients during a 25-year period.
    Leukemia, 1995, Volume: 9, Issue:10

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Daunorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Retrospective Studies; Treatment Outcome; Vincristine

1995
Chemotherapy plays a major role in the inhibition of catch-up growth during maintenance therapy for childhood acute lymphoblastic leukemia.
    Pediatrics, 1995, Volume: 96, Issue:4 Pt 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Growth; Growth Disorders; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1995
[Electrolytic changes in children with acute lymphoblastic leukemia during remission induction].
    Sangre, 1995, Volume: 40, Issue:3

    Topics: Adolescent; Allopurinol; Anions; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Blood Urea Nitrogen; Cations; Child; Child, Preschool; Cohort Studies; Creatinine; Epirubicin; Female; Humans; Hydrocortisone; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Serum Albumin; Uric Acid; Vincristine; Water-Electrolyte Imbalance

1995
Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission: factors predictive of survival, relapse and graft-versus-host disease.
    Bone marrow transplantation, 1995, Volume: 15, Issue:6

    Topics: Actuarial Analysis; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cause of Death; Child; Child, Preschool; Combined Modality Therapy; Cyclosporine; Cytarabine; Disease-Free Survival; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Male; Melphalan; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Survival Analysis; Treatment Outcome; Whole-Body Irradiation

1995
An assay for the determination of reduced methotrexate accumulation in cells displaying limited viability in vitro.
    Cancer letters, 1995, Oct-20, Volume: 97, Issue:1

    Topics: Animals; Cryopreservation; Freezing; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidine; Tumor Cells, Cultured

1995
CNS chemoradiotherapy of childhood leukemia: the plot thickens but the ending bodes well.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy; Recurrence; Sex Factors

1995
Pubertal growth in young adult survivors of childhood leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Height; Brain Neoplasms; Child; Combined Modality Therapy; Cranial Irradiation; Daunorubicin; Female; Follow-Up Studies; Growth; Humans; Male; Menarche; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Puberty; Radiotherapy; Retrospective Studies; Sex Factors; Vincristine

1995
Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations.
    Blood, 1995, Jul-15, Volume: 86, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; DNA Mutational Analysis; DNA, Neoplasm; Drug Resistance; Female; Gene Amplification; Gene Expression Regulation, Leukemic; Genes, p53; Humans; Infant; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured

1995
Leukoencephalopathy detectable by magnetic resonance imaging: much ado about nothing? Regarding Matsumoto et al. IJROBP 32:913-918; 1995.
    International journal of radiation oncology, biology, physics, 1995, Jul-15, Volume: 32, Issue:4

    Topics: Brain; Child, Preschool; Drug Administration Schedule; Humans; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy

1995
Leukoencephalopathy in childhood hematopoietic neoplasm caused by moderate-dose methotrexate and prophylactic cranial radiotherapy--an MR analysis.
    International journal of radiation oncology, biology, physics, 1995, Jul-15, Volume: 32, Issue:4

    Topics: Adolescent; Brain; Brain Damage, Chronic; Child; Child, Preschool; Cranial Irradiation; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis

1995
Prognosis and treatment of seizures in children with acute lymphoblastic leukemia.
    Epilepsia, 1995, Volume: 36, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Daunorubicin; Epilepsy; Female; Humans; Incidence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Retrospective Studies; Seizures; Vincristine

1995
Intracellular pharmacology and biochemistry of methotrexate and 6-mercaptopurine in childhood acute lymphoblastic leukemia.
    Advances in experimental medicine and biology, 1994, Volume: 370

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Humans; Infusions, Intravenous; Leucovorin; Leukocytes, Mononuclear; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Pyrimidines

1994
The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia.
    Blood, 1995, Sep-15, Volume: 86, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Humans; Infusions, Intravenous; Injections, Spinal; Life Tables; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Risk Factors; Survival Rate; Vincristine

1995
MACOP-B +/- radiation therapy for diffuse large cell lymphoma. Analysis of the Stanford results according to prognostic indices.
    Cancer, 1993, Jun-15, Volume: 71, Issue:12

    Topics: Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Risk Factors; Survival Rate; Vincristine

1993
Granulocyte colony-stimulating factor (G-CSF) as an adjunct to induction chemotherapy of adult acute lymphoblastic leukemia (ALL).
    Annals of hematology, 1993, Volume: 66, Issue:6

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Cells; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fever; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Platelet Count; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tegafur; Time Factors

1993
Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.
    Leukemia, 1993, Volume: 7, Issue:7

    Topics: Adult; Age Factors; Child; Drug Resistance; Humans; In Vitro Techniques; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

1993
The frequency of micronuclei in bone-marrow erythroblasts during the treatment of childhood acute lymphoblastic leukaemia.
    Mutation research, 1993, Volume: 303, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Daunorubicin; Erythroblasts; Female; Humans; Infant; Male; Methotrexate; Micronucleus Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Vincristine

1993
Treatment of poor prognosis non-Hodgkin's lymphoma with intensive, inpatient combination chemotherapy of brief duration: long-term followup.
    Leukemia & lymphoma, 1993, Volume: 10, Issue:6

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Prognosis; Survival Analysis; Vincristine

1993
Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia.
    Blood, 1995, Apr-01, Volume: 85, Issue:7

    Topics: Adolescent; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Marrow; Child; Child, Preschool; Cytarabine; Erythrocytes; Female; Humans; Lymphocytes; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neoplasm Proteins; Neoplastic Stem Cells; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Teniposide; Treatment Failure

1995
Selective treatment of SCID mice bearing methotrexate-transport-resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection.
    Blood, 1995, May-15, Volume: 85, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Drug Resistance; Humans; Leucovorin; Methotrexate; Mice; Mice, SCID; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Heterologous; Trimetrexate

1995
[Central nervous system relapses in acute lymphoblastic leukemia and different methods of prophylaxis].
    Acta haematologica Polonica, 1995, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Risk Factors; Survival Analysis

1995
Changes in the oral health of children during treatment for acute lymphoblastic leukaemia.
    International journal of paediatric dentistry, 1994, Volume: 4, Issue:1

    Topics: Adolescent; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chlorhexidine; Daunorubicin; Dental Plaque Index; DMF Index; Female; Gingivitis; Humans; Infant; Longitudinal Studies; Male; Methotrexate; Oral Hygiene Index; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Statistics, Nonparametric; Vincristine

1994
[Long-term follow up of therapy-conditioned cerebral changes in acute lymphatic leukemia].
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1995, Volume: 162, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Combined Modality Therapy; Dementia; Follow-Up Studies; Humans; Infant; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quadriplegia; Radiotherapy Dosage; Remission Induction; Time Factors; Tomography, X-Ray Computed

1995
Urinary N-acetyl-beta-D-glucosaminidase activity in leukaemic children during high-dose methotrexate therapy.
    Haematologia, 1995, Volume: 26, Issue:3

    Topics: Acetylglucosaminidase; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Burkitt Lymphoma; Child; Creatinine; Diuresis; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Kidney Tubules, Proximal; Leucovorin; Leukemia; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1995
Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia.
    Blood, 1995, Jan-15, Volume: 85, Issue:2

    Topics: Adolescent; Biological Transport; Child; Child, Preschool; Drug Resistance; Female; Humans; Infant; Leukemia, Erythroblastic, Acute; Leukocyte Count; Life Tables; Lymphocytes; Male; Methotrexate; Neoplasm Proteins; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Tetrahydrofolate Dehydrogenase; Time Factors; Tumor Cells, Cultured

1995
Small noncleaved cell lymphoma and leukemia in adults. A retrospective study of 65 adults treated with the LMB pediatric protocols.
    Blood, 1995, Feb-01, Volume: 85, Issue:3

    Topics: Adolescent; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Cyclophosphamide; Cytarabine; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome

1995
Pharmacokinetics of HD-MTX in infants, children, and adolescents with non-B acute lymphoblastic leukemia.
    Medical and pediatric oncology, 1995, Volume: 24, Issue:3

    Topics: Adolescent; Age Factors; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Retrospective Studies

1995
An intensive re-treatment protocol for children with an isolated CNS relapse of acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Clinical Protocols; Combined Modality Therapy; Critical Care; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Recurrence; Remission Induction; Time Factors

1995
High-performance liquid chromatographic determination of methotrexate, 7-hydroxymethotrexate, 5-methyltetrahydrofolic acid and folinic acid in serum and cerebrospinal fluid.
    Journal of chromatography. B, Biomedical applications, 1994, Nov-04, Volume: 661, Issue:1

    Topics: Calibration; Child; Chromatography, High Pressure Liquid; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Specimen Handling; Tetrahydrofolates

1994
Childhood acute lymphoblastic leukemia (ALL): sister chromatid exchange (SCE) frequency and lymphocyte subpopulations during therapy.
    Leukemia, 1995, Volume: 9, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chromosomes, Human; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Immunophenotyping; Infant; Lymphocyte Count; Lymphocyte Subsets; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Sister Chromatid Exchange; Time Factors; Vincristine

1995
Impact of reinduction regimens for relapsed and refractory acute lymphoblastic leukemia in adults.
    American journal of hematology, 1994, Volume: 45, Issue:4

    Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Aspartate-Ammonia Ligase; Clinical Trials as Topic; Cytarabine; Dose-Response Relationship, Drug; Humans; Idarubicin; Incidence; Methotrexate; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Salvage Therapy

1994
Limitation of therapy in the treatment of childhood cancer: toxicity versus cure.
    Lancet (London, England), 1994, Jul-23, Volume: 344, Issue:8917

    Topics: Child; Cranial Irradiation; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Assessment; Survival Rate

1994
Association of 1800 cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukaemia. ISPACC. International Study Group on Psychosocial Aspects of Childhood Cancer.
    Lancet (London, England), 1994, Jul-23, Volume: 344, Issue:8917

    Topics: Adolescent; Age Factors; Child; Child, Preschool; Cranial Irradiation; Female; Humans; Injections, Spinal; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Retrospective Studies; Wechsler Scales

1994
Educational attainment in long-term survivors of childhood acute lymphoblastic leukemia.
    JAMA, 1994, Nov-09, Volume: 272, Issue:18

    Topics: Adolescent; Adult; Age of Onset; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Education, Special; Educational Status; Female; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk; Survivors

1994
Second malignant tumors after elective end of therapy for a first cancer in childhood: a multicenter study in Italy.
    International journal of cancer, 1994, Nov-15, Volume: 59, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Central Nervous System Neoplasms; Child; Cranial Irradiation; Cross-Sectional Studies; Female; Follow-Up Studies; Hodgkin Disease; Humans; Incidence; Injections, Spinal; Italy; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasms, Second Primary; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Registries; Risk Factors; Wilms Tumor

1994
Bone marrow transplantation for primary refractory acute leukaemia.
    Bone marrow transplantation, 1994, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Graft Rejection; Graft vs Host Disease; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Remission Induction; Survival Rate

1994
Methotrexate and 6-mercaptopurine maintenance therapy for childhood acute lymphoblastic leukemia: dose adjustments by white cell counts or by pharmacokinetic parameters?
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Platelet Count; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1994
Intensive intravenous methotrexate and mercaptopurine treatment of higher-risk non-T, non-B acute lymphocytic leukemia: A Pediatric Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1994, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Analysis; Treatment Outcome

1994
[The effect of polychemotherapy on hemopoiesis in acute lymphoblastic leukemia in children].
    Gematologiia i transfuziologiia, 1993, Volume: 38, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Female; Hematopoiesis; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Time Factors; Vincristine

1993
A dental complication involving Pseudomonas during chemotherapy for acute lymphoblastic leukemia.
    The Journal of clinical pediatric dentistry, 1994,Spring, Volume: 18, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Dental Care for Chronically Ill; Female; Humans; Immunocompromised Host; Methotrexate; Periapical Abscess; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pseudomonas aeruginosa; Pseudomonas Infections; Remission Induction; Vincristine

1994
Prognostic factors for long-term survival in leukemic marrow recipients with special emphasis on age and prophylaxis for graft-versus-host disease.
    Clinical transplantation, 1994, Volume: 8, Issue:3 Pt 1

    Topics: Adolescent; Adult; Age Factors; Aged; Bone Marrow Transplantation; Cause of Death; Child; Child, Preschool; Cyclosporine; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Infant; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Risk Factors; Survival Rate

1994
Successful bone marrow transplant for a patient with T-lymphoblastic lymphoma in second remission preconditioned by total-body irradiation plus melphalan and etoposide.
    Transplantation proceedings, 1994, Volume: 26, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cyclosporine; Etoposide; Graft vs Host Disease; Humans; Male; Melphalan; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Whole-Body Irradiation

1994
Poor outcome of intensive chemotherapy for adult acute lymphoblastic leukemia: a possible dose effect.
    Leukemia, 1994, Volume: 8, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Leucovorin; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Remission Induction; Retrospective Studies; Survival Rate; Teniposide; Vincristine

1994
Histologic changes in dental morphology induced by high dose chemotherapy and total body irradiation.
    Oral surgery, oral medicine, and oral pathology, 1994, Volume: 77, Issue:1

    Topics: Abnormalities, Radiation-Induced; Amelogenesis; Antineoplastic Agents; Asparaginase; Bone Marrow Transplantation; Child, Preschool; Cyclophosphamide; Cytarabine; Dental Arch; Dental Enamel Hypoplasia; Dentinogenesis; Doxorubicin; Female; Humans; Immunosuppressive Agents; Maxillofacial Development; Mercaptopurine; Methotrexate; Odontogenesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Tooth Eruption; Tooth Root; Vincristine; Whole-Body Irradiation

1994
2,4-diamino-7-hydroxy-pteridines in biological fluids of patients on high-dose methotrexate.
    Clinica chimica acta; international journal of clinical chemistry, 1993, Nov-15, Volume: 220, Issue:2

    Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pteridines

1993
Changes in cell and protein content of cerebrospinal fluid in children with acute lymphoblastic leukaemia after allogeneic bone marrow transplantation.
    Bone marrow transplantation, 1993, Volume: 12, Issue:6

    Topics: Adolescent; Arachnoiditis; Bone Marrow Transplantation; Brain Injuries; Brain Neoplasms; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Transplantation, Homologous

1993
[Treatment of acute lymphoblastic leukemia in adults by the modified protocol of L-10M (Sloan-Kettering): long-term outcome].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1994, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Treatment Outcome

1994
[Relapse of acute leukemia after allogeneic bone marrow transplantation].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1994, Volume: 35, Issue:2

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Female; Graft vs Host Disease; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Rate

1994
Successful treatment of acute lymphoblastic leukemia in a child with cystic fibrosis.
    Medical and pediatric oncology, 1994, Volume: 22, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Cystic Fibrosis; Cytarabine; Daunorubicin; Female; Humans; Mercaptopurine; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Teniposide; Vincristine

1994
Myelopathy after intrathecal chemotherapy. A case report with unique magnetic resonance imaging changes.
    Cancer, 1994, Jun-15, Volume: 73, Issue:12

    Topics: Adolescent; Antineoplastic Agents; Contrast Media; Cytarabine; Drug Combinations; Female; Gadolinium DTPA; Humans; Injections, Spinal; Magnetic Resonance Imaging; Meglumine; Methotrexate; Organometallic Compounds; Paraplegia; Pentetic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases

1994
Liver function studies in children with acute lymphocytic leukemia after cessation of therapy.
    Medical and pediatric oncology, 1994, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Child; Daunorubicin; Follow-Up Studies; Humans; Liver; Mercaptopurine; Methotrexate; Nervous System Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine

1994
Acute leukemia in association with Langerhans cell histiocytosis.
    Medical and pediatric oncology, 1994, Volume: 23, Issue:2

    Topics: Adolescent; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Etoposide; Female; Histiocytosis, Langerhans-Cell; Humans; Infant; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Registries; Retrospective Studies; Surveys and Questionnaires; Vinblastine; Vincristine

1994
High grade pyrexia following bone marrow transplantation as a neurotoxic complication of high-dose chemotherapy and radiotherapy in the UKALL XII Trial.
    Bone marrow transplantation, 1994, Volume: 13, Issue:2

    Topics: Adult; Bone Marrow Transplantation; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Fever; Humans; Male; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; United Kingdom; Whole-Body Irradiation

1994
Toxicity following concurrent intrathecal and moderate-dose intravenous methotrexate.
    Leukemia, 1993, Volume: 7, Issue:11

    Topics: Adolescent; Body Surface Area; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Injections, Spinal; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Trimethoprim, Sulfamethoxazole Drug Combination

1993
Incidence of cataracts after single fraction total body irradiation: the role of steroids and graft versus host disease.
    Bone marrow transplantation, 1993, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Bone Marrow Purging; Bone Marrow Transplantation; Cataract; Cataract Extraction; Child; Child, Preschool; Cohort Studies; Graft vs Host Disease; Humans; Incidence; Life Tables; Lymphocyte Depletion; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiation Injuries; Risk; Whole-Body Irradiation

1993
Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
    Leukemia, 1993, Volume: 7, Issue:12

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Division; Drug Resistance; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured

1993
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.
    Archives of disease in childhood, 1993, Volume: 69, Issue:5

    Topics: Bone Marrow; Child; Child, Preschool; Female; Guanine Nucleotides; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Values; Thionucleotides; Vincristine

1993
Proteinuria due to suboptimal hydration with high-dose methotrexate therapy.
    Cancer chemotherapy and pharmacology, 1993, Volume: 33, Issue:3

    Topics: Adolescent; Bone Neoplasms; Burkitt Lymphoma; Child; Female; Fluid Therapy; Glomerular Filtration Rate; Glucose; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteinuria; Sodium Bicarbonate

1993
Intelligence function in children with acute lymphoblastic leukemia after treatment.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 1993, Volume: 8, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Injections, Spinal; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Wechsler Scales

1993
Studies on the cross resistance of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Antineoplastic Agents; Cell Division; Cell Survival; Clone Cells; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Floxuridine; Folic Acid Antagonists; Humans; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

1993
Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Binding Sites; Biological Transport; Carrier Proteins; Cell Line; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Tetrahydrofolates; Tumor Cells, Cultured

1993
Determinants of the disparate antitumor effects of (6R)5,10-dideaza-5,6,7,8- tetrahydrofolate and methotrexate toward methotrexate resistant CCRF-CEM cells, characterized by severely impaired antifolate membrane transport.
    Advances in experimental medicine and biology, 1993, Volume: 338

    Topics: Antineoplastic Agents; Carrier Proteins; Cell Line; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Tetrahydrofolates; Tumor Cells, Cultured

1993
Risk taking and decision making of adolescent long-term survivors of cancer.
    Oncology nursing forum, 1993, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Alcohol Drinking; Attitude to Health; Combined Modality Therapy; Cranial Irradiation; Decision Making; Educational Status; Female; Humans; Injections, Spinal; Male; Marijuana Smoking; Methotrexate; Nursing Methodology Research; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Psychology, Adolescent; Risk-Taking; Smoking; Surveys and Questionnaires; Time Factors

1993
Long-term follow-up of treatment and potential cure of adult acute lymphocytic leukemia with MOAD: a non-anthracycline containing regimen.
    Leukemia, 1993, Volume: 7, Issue:8

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Vincristine

1993
Pharmacokinetics and in vitro studies of l-leucovorin. Comparison with the d and d,l-leucovorin.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1993, Volume: 4 Suppl 2

    Topics: Drug Synergism; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Pediococcus; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stereoisomerism; Tumor Cells, Cultured

1993
Changes in the oral microflora during cytotoxic chemotherapy in children being treated for acute leukemia.
    Oral surgery, oral medicine, and oral pathology, 1993, Volume: 76, Issue:2

    Topics: Adolescent; Analysis of Variance; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Candida albicans; Candidiasis, Oral; Chi-Square Distribution; Child; Child, Preschool; Chlorhexidine; Colony Count, Microbial; Cytarabine; Daunorubicin; Etoposide; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Infant; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Mouth; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Streptococcus mutans; Thioguanine; Trimethoprim, Sulfamethoxazole Drug Combination; Vincristine

1993
Late relapse after allogeneic bone marrow transplantation for Philadelphia-positive acute lymphoblastic leukaemia.
    Acta haematologica, 1993, Volume: 89, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Combined Modality Therapy; Daunorubicin; Humans; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Recurrence; Remission Induction; Time Factors; Transplantation, Homologous; Vincristine

1993
[Acute lymphoblastic leukemia in infants--results of treatment according to infant leukemia protocol--POG 8493].
    Acta haematologica Polonica, 1993, Volume: 24, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cortisone; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Administration Schedule; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Vincristine

1993
Long-term effects of treatment for acute lymphoblastic leukemia with and without cranial irradiation on growth and puberty: a comparative study.
    Pediatric research, 1993, Volume: 33, Issue:6

    Topics: Adolescent; Body Height; Brain; Child; Child, Preschool; Combined Modality Therapy; Female; Growth; Growth Disorders; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Puberty

1993
A cancer patient with central venous catheter-related sepsis caused by Tsukamurella paurometabolum (Gordona aurantiaca)
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1993, Volume: 17, Issue:2

    Topics: Actinomycetales Infections; Aged; Catheterization, Central Venous; Female; Humans; Immunocompromised Host; Methotrexate; Microbial Sensitivity Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rhodococcus

1993
Ten years' experience with LSA2-L2 therapy for childhood advanced lymphoblastic lymphoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

1993
Acute graft-versus-host disease prophylaxis with methotrexate and cyclosporine after busulfan and cyclophosphamide in patients with hematologic malignancies.
    Blood, 1993, Feb-01, Volume: 81, Issue:3

    Topics: Adult; Busulfan; Chronic Disease; Combined Modality Therapy; Cyclophosphamide; Cyclosporine; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Incidence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

1993
Methotrexate, cyclosporine, or both to prevent graft-versus-host disease after HLA-identical sibling bone marrow transplants for early leukemia?
    Blood, 1993, Feb-15, Volume: 81, Issue:4

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Female; Graft vs Host Disease; Histocompatibility; Humans; Infant; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1993
Cranial computed tomography in children with acute lymphoblastic leukemia after prophylactic treatment with cranial radiation therapy and intrathecal methotrexate.
    Cancer, 1993, Mar-15, Volume: 71, Issue:6

    Topics: Brain; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Injections, Spinal; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Tomography, X-Ray Computed

1993
Severe interaction between methotrexate and a macrolide-like antibiotic.
    Journal of the National Cancer Institute, 1993, Apr-07, Volume: 85, Issue:7

    Topics: Adolescent; Anti-Bacterial Agents; Drug Interactions; Humans; Macrolides; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Virginiamycin

1993
Intensive alternating drug pairs for treatment of high-risk childhood acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study.
    Cancer, 1993, May-01, Volume: 71, Issue:9

    Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cytarabine; Daunorubicin; Drug Administration Schedule; Female; Humans; Hydrocortisone; Infant; Injections, Intramuscular; Injections, Intravenous; Injections, Spinal; Leukemia-Lymphoma, Adult T-Cell; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; Treatment Failure

1993
Increased risk of neurological relapse in acute lymphoblastic leukemias with high levels of cerebrospinal fluid thymidine kinase at diagnosis.
    Leukemia & lymphoma, 1993, Volume: 9, Issue:1-2

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Injections, Spinal; Leukemic Infiltration; Leukocyte Count; Male; Meninges; Methotrexate; Middle Aged; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prognosis; Remission Induction; Risk Factors; Thymidine Kinase; Time Factors

1993
[Treatment of adult acute lymphoblastic leukemia with DCVP-l-asp protocol].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1993, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Survival Rate; Vincristine

1993
Effect of chemotherapy on the energy and protein metabolism of children near the end of treatment for acute lymphoblastic leukemia.
    The American journal of clinical nutrition, 1993, Volume: 57, Issue:5

    Topics: Adolescent; Child; Energy Metabolism; Female; Humans; Male; Mercaptopurine; Methotrexate; Models, Theoretical; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteins; Remission Induction

1993
Central nervous system treatment in childhood acute lymphoblastic leukemia. Long-term follow-up of patients diagnosed between 1973 and 1985.
    Cancer, 1993, Jul-01, Volume: 72, Issue:1

    Topics: Brain Neoplasms; Child; Child, Preschool; Cranial Irradiation; Humans; Infant; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Survival Rate

1993
Child cerebrospinal fluid analysis by capillary electrophoresis and laser-induced fluorescence detection.
    Journal of chromatography. A, 1995, Nov-24, Volume: 717, Issue:1-2

    Topics: Adolescent; Amines; Amino Acids; Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Electrophoresis, Capillary; Female; Humans; Lasers; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spectrometry, Fluorescence

1995
Cured of acute lymphoblastic leukaemia but lost for words.
    Neuropediatrics, 1995, Volume: 26, Issue:5

    Topics: Adolescent; Anomia; Antimetabolites, Antineoplastic; Cranial Irradiation; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Status Epilepticus

1995
Evaluation of clinical assays for measuring high-dose methotrexate in plasma.
    Clinical chemistry, 1996, Volume: 42, Issue:1

    Topics: Child; Child, Preschool; Chromatography, High Pressure Liquid; Cross Reactions; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Fluorescence Polarization Immunoassay; Humans; Immunoenzyme Techniques; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results

1996
Successful treatment of intrathecal methotrexate overdose by using ventriculolumbar perfusion and intrathecal instillation of carboxypeptidase G2.
    Mayo Clinic proceedings, 1996, Volume: 71, Issue:2

    Topics: Antimetabolites, Antineoplastic; Child; Drug Overdose; gamma-Glutamyl Hydrolase; Humans; Injections, Spinal; Lumbosacral Region; Male; Methotrexate; Perfusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1996
Plasma free iron and chemotherapy toxicity.
    Lancet (London, England), 1996, Feb-10, Volume: 347, Issue:8998

    Topics: Antineoplastic Agents; Doxorubicin; Free Radicals; Humans; Iron; Iron Chelating Agents; Methotrexate; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transferrin

1996
Clinical and experimental pharmacokinetic interaction between 6-mercaptopurine and methotrexate.
    Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:5

    Topics: Adolescent; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Biotransformation; Child; Child, Preschool; Drug Interactions; Female; HL-60 Cells; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Rats, Wistar; Time Factors

1996
High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia. Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Leukocyte Count; Male; Methotrexate; Netherlands; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Treatment Outcome

1996
Mutations in the gene for human dihydrofolate reductase: an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate.
    Leukemia, 1996, Volume: 10, Issue:3

    Topics: Adolescent; Animals; Antimetabolites, Antineoplastic; Base Sequence; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Genes; Genetic Vectors; Humans; Infant; Male; Methotrexate; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retroviridae; Tetrahydrofolate Dehydrogenase

1996
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
    Biochemical pharmacology, 1996, May-03, Volume: 51, Issue:9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Homocysteine; Humans; Mercaptopurine; Methionine; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine

1996
True histiocytic lymphoma following therapy for lymphoblastic neoplasms.
    Blood, 1996, Jun-15, Volume: 87, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Etoposide; Fatal Outcome; Humans; Ifosfamide; Lymphoma, Large B-Cell, Diffuse; Male; Mediastinal Neoplasms; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasms, Second Primary; Neoplastic Stem Cells; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Remission Induction; Scapula; Spinal Neoplasms; Vincristine

1996
Intrathecal leucovorin after intrathecal methotrexate overdose.
    Journal of pediatric hematology/oncology, 1996, Volume: 18, Issue:3

    Topics: Catheterization, Central Venous; Child; Cytarabine; Drug Overdose; Humans; Hydrocortisone; Injections, Spinal; Leucovorin; Male; Medication Errors; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1996
Childhood acute lymphoblastic leukemia relapse in the uterine cervix.
    Journal of pediatric hematology/oncology, 1996, Volume: 18, Issue:3

    Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Neoplasms; Child; Cyclophosphamide; Daunorubicin; Female; Follow-Up Studies; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Ultrasonography; Uterine Cervical Neoplasms; Vaginal Smears; Vincristine

1996
[Separation of methotrexate-polyglutamates by capillary electrophoresis and its application to the measurement of gamma-glutamyl hydrolase activity in human leukemia cells in culture].
    Rinsho byori. The Japanese journal of clinical pathology, 1996, Volume: 44, Issue:1

    Topics: Down-Regulation; Electrophoresis, Capillary; gamma-Glutamyl Hydrolase; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Tumor Cells, Cultured

1996
Induction toxicity of a modified Memorial Sloan-Kettering-New York II Protocol in children with relapsed acute lymphoblastic leukemia: a single institution study.
    Medical and pediatric oncology, 1996, Volume: 27, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Daunorubicin; Female; Humans; Male; Methotrexate; Neutropenia; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Vincristine

1996
Effectiveness of intensified rotational combination chemotherapy for late hematologic relapse of childhood acute lymphoblastic leukemia.
    Blood, 1996, Aug-01, Volume: 88, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Disease-Free Survival; Drug Administration Schedule; Female; Growth Disorders; Humans; Hydrocortisone; Leukemic Infiltration; Life Tables; Male; Meninges; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Prospective Studies; Remission Induction; Salvage Therapy; Survival Analysis; Survival Rate; Teniposide; Testis; Time Factors; Treatment Outcome; Vincristine

1996
Magnetic resonance imaging and neurological evaluation after treatment with high-dose methotrexate for acute lymphocytic leukaemia in young children.
    Acta paediatrica (Oslo, Norway : 1992), 1996, Volume: 85, Issue:4

    Topics: Age Factors; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neurologic Examination; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction

1996
[Radiological case of the month. Leukoencephalopathy caused by methotrexate in a child treated for acute lymphoblastic leukemia].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1996, Volume: 3, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Demyelinating Diseases; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

1996
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD).
    American journal of hematology, 1996, Volume: 52, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Female; Humans; Male; Methotrexate; Middle Aged; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

1996
Acute tumor lysis syndrome following intrathecal methotrexate.
    Leukemia & lymphoma, 1996, Volume: 22, Issue:3-4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Humans; Injections, Spinal; Male; Meninges; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Lysis Syndrome

1996
Melphalan-total body irradiation and autologous bone marrow transplantation for adult acute leukemia beyond first remission.
    Bone marrow transplantation, 1996, Volume: 18, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Bone Marrow Transplantation; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Leukemia; Leukemia, Myeloid; Male; Melphalan; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Salvage Therapy; Survival Analysis; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; Whole-Body Irradiation

1996
P300 abnormalities in long-time survivors of acute lymphoblastic leukemia in childhood--side effects of CNS prophylaxis?
    Neuropediatrics, 1996, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Brain; Brain Mapping; Cerebral Cortex; Child; Combined Modality Therapy; Cranial Irradiation; Event-Related Potentials, P300; Female; Follow-Up Studies; Humans; Leukemic Infiltration; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage

1996
Lenńox-Gastaut syndrome associated with leukoencephalopathy.
    Pediatric neurology, 1996, Volume: 15, Issue:1

    Topics: Adolescent; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Damage, Chronic; Calcinosis; Cranial Irradiation; Cytarabine; Dementia; Doxorubicin; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Humans; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Movement Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiation Injuries; Syndrome; Vincristine

1996
Intensive oral methotrexate protects against lymphoid marrow relapse in childhood B-precursor acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:10

    Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

1996
Acute lymphoblastic leukemia in Ehlers-Danlos syndrome.
    International journal of hematology, 1996, Volume: 64, Issue:3-4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Cytarabine; Disease-Free Survival; Doxorubicin; Ehlers-Danlos Syndrome; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine

1996
[Toxicity of high dose methotrexate repeated infusions in children treated for acute lymphoblastic leukemia and osteosarcoma].
    Minerva pediatrica, 1996, Volume: 48, Issue:5

    Topics: Antineoplastic Agents; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Kidney; Liver; Methotrexate; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytopenia

1996
[Obesity as the first manifestation of central nervous system involvement in acute lymphoblastic leukemia].
    Pediatria polska, 1996, Volume: 71, Issue:8

    Topics: Antineoplastic Agents; Body Mass Index; Child; Combined Modality Therapy; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Methotrexate; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Dosage; Recurrence

1996
Chemotherapy for acute lymphoblastic leukemia may cause subtle changes of the spinal cord detectable by somatosensory evoked potentials.
    Medical and pediatric oncology, 1997, Volume: 28, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Evoked Potentials, Somatosensory; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Neural Conduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reaction Time; Remission Induction; Spinal Cord

1997
Quantitative EEG in long-term survivors of acute lymphoblastic leukemia.
    Pediatric neurology, 1996, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Cerebral Cortex; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Drug; Electroencephalography; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Signal Processing, Computer-Assisted

1996
Methotrexate plasma pharmacokinetics: importance of assay method.
    Cancer letters, 1996, Nov-29, Volume: 108, Issue:2

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1996
Brain perfusion after treatment of childhood acute lymphoblastic leukemia.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1997, Volume: 38, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Child; Child, Preschool; Cranial Irradiation; Cysteine; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Neurologic Examination; Organotechnetium Compounds; Oximes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon

1997
Testicular morphological changes in children with acute lymphoblastic leukemia following chemotherapy.
    Acta paediatrica Japonica : Overseas edition, 1996, Volume: 38, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Child; Child, Preschool; Cyclophosphamide; Doxorubicin; Etoposide; Humans; Hydrocortisone; Leydig Cells; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Sertoli Cells; Spermatogonia; Testis

1996
Time course of methotrexate polyglutamate formation and degradation in the pre-B-leukaemia cell line Nalm6 and in lymphoblasts from children with leukaemia.
    European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:12

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Resistance, Neoplasm; Humans; Kinetics; Lymphocytes; Male; Methotrexate; Polyglutamic Acid; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

1996
Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression.
    Blood, 1997, Feb-01, Volume: 89, Issue:3

    Topics: Adolescent; Adult; Aged; Biological Transport; Blast Crisis; Carrier Proteins; Child; Child, Preschool; Drug Resistance; Fluoresceins; Folic Acid; Humans; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein

1997
Toxicity of CNS prophylaxis for childhood leukemia.
    Oncology (Williston Park, N.Y.), 1997, Volume: 11, Issue:2

    Topics: Antimetabolites, Antineoplastic; Central Nervous System Diseases; Child; Cognition; Cranial Irradiation; Female; Growth; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1997
Development of the anterior cingulate syndrome in a child due to delayed necrotising methotrexate leukoencephalopathy.
    Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:3

    Topics: Akinetic Mutism; Brain Diseases; Child; Cranial Irradiation; Demyelinating Diseases; Fatal Outcome; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

1997
In vitro drug sensitivity testing can predict induction failure and early relapse of childhood acute lymphoblastic leukemia.
    Blood, 1997, Apr-15, Volume: 89, Issue:8

    Topics: Aclarubicin; Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bleomycin; Bone Marrow; Cell Survival; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Follow-Up Studies; Humans; Infant; Infant, Newborn; Life Tables; Melphalan; Methotrexate; Mitomycin; Mitoxantrone; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Recurrence; Remission Induction; Tumor Cells, Cultured; Vincristine

1997
Final height and puberty in 40 patients after antileukaemic treatment during childhood.
    European journal of pediatrics, 1997, Volume: 156, Issue:4

    Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Radiation; Female; Growth; Growth Disorders; Humans; Longitudinal Studies; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Puberty

1997
Systemic effect of intrathecal methotrexate during the initial phase of treatment of childhood acute lymphoblastic leukemia. The European Organization for Research and Treatment of Cancer Children's Leukemia Cooperative Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:5

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Blast Crisis; Cell Count; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Retrospective Studies

1997
Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:5

    Topics: Adolescent; Adult; Antidotes; Antimetabolites, Antineoplastic; Carboxypeptidases; Child; Child, Preschool; Female; Humans; Infant; Kidney; Kidney Diseases; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Thymidine

1997
Treatment of isolated testicular recurrence of acute lymphoblastic leukemia without radiotherapy. Report from the Dutch Late Effects Study Group.
    Cancer, 1997, Jun-01, Volume: 79, Issue:11

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Child, Preschool; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Testicular Neoplasms

1997
Serum aminotransferase elevation during and following treatment of childhood acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Liver Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transaminases; Treatment Outcome

1997
Nutritional state alterations in children with acute lymphoblastic leukemia during induction and consolidation of chemotherapy.
    Archives of medical research, 1997,Summer, Volume: 28, Issue:2

    Topics: Adolescent; Anthropometry; Antineoplastic Combined Chemotherapy Protocols; Arm; Asparaginase; Body Constitution; Child; Child, Preschool; Cohort Studies; Cytarabine; Drug Administration Schedule; Energy Metabolism; Epirubicin; Female; Gastrointestinal Diseases; Hospitals, General; Hospitals, Pediatric; Humans; Infant; Male; Mercaptopurine; Methotrexate; Nutrition Disorders; Nutritional Status; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk; Skinfold Thickness; Vincristine

1997
On the prognostic value of systemic methotrexate clearance in childhood acute lymphocytic leukemia.
    Leukemia research, 1997, Volume: 21, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Probability; Prognosis; Recurrence; Reproducibility of Results; Risk Assessment

1997
[Psychological functions in children treated for acute lymphatic leukemia. A 5-year follow-up of three different age groups of children].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1997, May-30, Volume: 117, Issue:14

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child Behavior; Cognition; Female; Follow-Up Studies; Humans; Intelligence Tests; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychological Tests; Social Adjustment

1997
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
    Blood, 1997, Aug-01, Volume: 90, Issue:3

    Topics: Acute Disease; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid Antagonists; HL-60 Cells; Humans; Indoles; Isoindoles; Kinetics; Leukemia, Myeloid; Methotrexate; Neoplasm Proteins; Organ Specificity; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured

1997
Role of cranial radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC count and good response to prednisone. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster groups.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:8

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cranial Irradiation; Daunorubicin; Female; Humans; Infant; Injections, Spinal; Leukemia-Lymphoma, Adult T-Cell; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Survival Rate; Vincristine

1997
Neurophysiological findings in long-term survivors of acute lymphoblastic leukaemia in childhood treated with the BFM protocol 81 SR-A/B.
    European journal of pediatrics, 1997, Volume: 156, Issue:9

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cerebral Cortex; Child; Child, Preschool; Daunorubicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Evoked Potentials, Visual; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Reaction Time; Vincristine

1997
[Inefficacy of exchange-transfusion in case of a methotrexate poisoning].
    Bulletin du cancer, 1997, Volume: 84, Issue:8

    Topics: Acute Kidney Injury; Adult; Antidotes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Diuretics; Drug Overdose; Exchange Transfusion, Whole Blood; Furosemide; Humans; Leucovorin; Male; Methotrexate; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Failure

1997
Salvage therapy for relapsed or refractory childhood acute lymphocytic leukemia by alternative administration a lymphoid- and myeloid-directed chemotherapeutic regimen consisting of dual modulation of ara-C, hydroxyurea, and etoposide.
    Leukemia research, 1997, Volume: 21, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dexamethasone; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Fever; Gastrointestinal Diseases; Humans; Hydrocortisone; Hydroxyurea; Leucovorin; Male; Methotrexate; Mitoxantrone; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Salvage Therapy; Treatment Outcome

1997
Assessment of brain perfusion by 99mTc-HMPAO SPECT in akinetic mutism due to high-dose intravenous methotrexate therapy.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1997, Volume: 13, Issue:10

    Topics: Akinetic Mutism; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Dominance, Cerebral; Dose-Response Relationship, Drug; Female; Frontal Lobe; Humans; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regional Blood Flow; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon

1997
Nerve lesions after therapy for childhood acute lymphoblastic leukemia.
    Cancer, 1998, Jan-01, Volume: 82, Issue:1

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Axons; Brachial Plexus; Case-Control Studies; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Demyelinating Diseases; Evoked Potentials, Somatosensory; Female; Humans; Male; Median Nerve; Methotrexate; Motor Skills; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Disorders; Reflex, Stretch; Risk Factors; Spinal Cord; Spinal Cord Diseases; Tibial Nerve; Vincristine

1998
Methotrexate, homocysteine, and seizures.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cysteine; Epilepsy, Tonic-Clonic; Homocysteine; Humans; Infant; Male; Methotrexate; Neurotransmitter Agents; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1998
Pure methotrexate encephalopathy presenting with seizures: CT and MRI features.
    Pediatric radiology, 1998, Volume: 28, Issue:2

    Topics: Antineoplastic Agents; Brain; Brain Diseases; Calcinosis; Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Tomography, X-Ray Computed

1998
Variable expression of RFC1 in human leukemia cell lines resistant to antifolates.
    Cancer letters, 1998, Feb-27, Volume: 124, Issue:2

    Topics: Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Tumor Cells, Cultured

1998
Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency.
    Acta paediatrica (Oslo, Norway : 1992), 1998, Volume: 87, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Follow-Up Studies; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1998
Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:1

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromosomes, Human, Pair 12; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Female; Humans; Infant; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-ets; Repressor Proteins; Transcription Factors; Translocation, Genetic

1998
Assessment of the emetogenic potential of intrathecal chemotherapy and response to prophylactic treatment with ondansetron.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1998, Volume: 6, Issue:2

    Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Nausea; Ondansetron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

1998
[Retrospective analysis of elderly patients > or = 60 years of age with acute leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1998, Volume: 39, Issue:3

    Topics: Aclarubicin; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; DNA; Female; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Retrospective Studies; Vincristine

1998
Acute lymphoblastic leukemia: dental health of children in maintenance therapy.
    The Journal of clinical pediatric dentistry, 1998,Spring, Volume: 22, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Case-Control Studies; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dental Care for Chronically Ill; Dental Caries; DMF Index; Female; Humans; Male; Mercaptopurine; Methotrexate; Oral Hygiene; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine

1998
Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia.
    Blood, 1998, Jul-15, Volume: 92, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Child; Child, Preschool; Cytarabine; Humans; Hydrocortisone; Injections, Spinal; Leukemic Infiltration; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence

1998
Clinical and pharmacokinetic risk factors for high-dose methotrexate-induced toxicity in children with acute lymphoblastic leukemia--a logistic regression analysis.
    Acta oncologica (Stockholm, Sweden), 1998, Volume: 37, Issue:3

    Topics: Bone Marrow; Child; Child, Preschool; Female; Humans; Liver; Male; Methotrexate; Mouth; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

1998
Cerebrospinal fluid concentrations of nitrate plus nitrite during the treatment of acute lymphoblastic leukaemia in childhood.
    Leukemia research, 1998, Volume: 22, Issue:8

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Infant; Methotrexate; Nitrates; Nitrites; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1998
[Peripheral blood stem cell transplantation in adult acute lymphoblastic leukemia as postremission therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1998, Volume: 25, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Transplantation Conditioning; Vincristine

1998
Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:9

    Topics: Adolescent; Amino Acid Sequence; Antimetabolites, Antineoplastic; Carrier Proteins; Child; Child, Preschool; Female; Gene Expression; Humans; Immunophenotyping; Infant; K562 Cells; Leukemia, T-Cell; Male; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Ploidies; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; Tritium; Tumor Cells, Cultured

1998
Reduced energy expenditure in preobese children treated for acute lymphoblastic leukemia.
    Pediatric research, 1998, Volume: 44, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Child; Energy Metabolism; Female; Humans; Male; Mercaptopurine; Methotrexate; Obesity; Physical Exertion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Reference Values; Survivors; Vincristine; Weight Gain

1998
Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:10

    Topics: Antimetabolites, Antineoplastic; Child; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase; Tumor Cells, Cultured

1998
Pharmacokinetics and pharmacodynamics of oral methotrexate and mercaptopurine in children with lower risk acute lymphoblastic leukemia: a joint children's cancer group and pediatric oncology branch study.
    Blood, 1998, Nov-15, Volume: 92, Issue:10

    Topics: Administration, Oral; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Asparaginase; Biological Availability; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; DNA Adducts; Erythrocytes; Female; Guanosine Triphosphate; Humans; Infant; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Recurrence; Thionucleotides; Treatment Outcome; Vincristine

1998
A case for the use of aminopterin in treatment of patients with leukemia based on metabolic studies of blasts in vitro.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:1

    Topics: Aminopterin; Cells, Cultured; Child; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1996
Therapeutic innovation: the up-front window.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Child; Clinical Trials as Topic; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Topotecan

1998
Evidence for cerebellar-frontal subsystem changes in children treated with intrathecal chemotherapy for leukemia: enhanced data analysis using an effect size model.
    Archives of neurology, 1998, Volume: 55, Issue:12

    Topics: Adolescent; Anthropometry; Antimetabolites, Antineoplastic; Cerebellum; Child; Cognition; Female; Follow-Up Studies; Frontal Lobe; Humans; Injections, Spinal; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1998
Childhood acute lymphoblastic leukaemia: outcomes of 54 consecutive patients treated in Auckland 1985-1991.
    The New Zealand medical journal, 1998, Nov-27, Volume: 111, Issue:1078

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Infant; Mercaptopurine; Methotrexate; New Zealand; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Prospective Studies; Radiotherapy, Adjuvant; Survival Analysis; Treatment Outcome; Vincristine

1998
Allogeneic and autologous bone marrow transplantation in single centre experience.
    Bone marrow transplantation, 1998, Volume: 22 Suppl 4

    Topics: Adult; Bone Marrow Transplantation; Cyclosporine; Graft vs Host Disease; Hodgkin Disease; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Registries; Transplantation, Autologous; Transplantation, Homologous

1998
Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay.
    Blood, 1999, Feb-01, Volume: 93, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Coloring Agents; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; HL-60 Cells; Humans; Infant; Infant, Newborn; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Neoplasm Proteins; Neoplastic Stem Cells; Polyglutamic Acid; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sensitivity and Specificity; Staining and Labeling; Tetrazolium Salts; Thiazoles; Thymidylate Synthase; U937 Cells

1999
Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity.
    Cancer biochemistry biophysics, 1998, Volume: 16, Issue:1-2

    Topics: Amino Acids; Animals; Asparagine; Cell Count; Dose-Response Relationship, Drug; Fluorouracil; Glutamine; Humans; Leukemia; Leukemia P388; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

1998
Outcomes and prognostic factors of Chinese children with acute lymphoblastic leukemia in Hong Kong: preliminary results.
    Medical and pediatric oncology, 1999, Volume: 32, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asian People; Asparaginase; Child; Child, Preschool; Daunorubicin; Female; Follow-Up Studies; Hong Kong; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Survival Rate; Treatment Outcome; Vincristine

1999
Intraventricular concentration times time (C x T) methotrexate and cytarabine for patients with recurrent meningeal leukemia and lymphoma.
    Cancer, 1999, Jan-15, Volume: 85, Issue:2

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cytarabine; Female; Humans; Injections, Intraventricular; Male; Meningeal Neoplasms; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Treatment Outcome

1999
[Adults treated as children for acute lymphocytic leukemia--methotrexate, late effects and quality of life].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1999, Feb-10, Volume: 119, Issue:4

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life; Regional Medical Programs; Socioeconomic Factors; Surveys and Questionnaires; Survivors; Treatment Outcome

1999
Allogeneic bone marrow transplantation in second remission of childhood acute lymphoblastic leukemia: a population-based case control study from the Nordic countries.
    Bone marrow transplantation, 1999, Volume: 23, Issue:6

    Topics: Adolescent; Bone Marrow Transplantation; Case-Control Studies; Child; Child, Preschool; Cyclosporine; Female; Finland; Graft vs Host Disease; Humans; Iceland; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Scandinavian and Nordic Countries; Time Factors; Treatment Outcome

1999
Neurodevelopmental outcome of infants with acute lymphoblastic leukemia: a Children's Cancer Group report.
    Cancer, 1999, Apr-15, Volume: 85, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Damage, Chronic; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Daunorubicin; Developmental Disabilities; Female; Follow-Up Studies; Humans; Infant; Injections, Spinal; Leucovorin; Leukemic Infiltration; Male; Mercaptopurine; Methotrexate; Movement Disorders; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Psychomotor Performance; Remission Induction; Risk; Socioeconomic Factors; Survivors; Vincristine

1999
Successful treatment of monoclonal, aggressive Epstein-Barr virus-associated B-cell lymphoproliferative disorder in a child with acute lymphoblastic leukemia.
    Medical and pediatric oncology, 1999, Volume: 32, Issue:6

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Child; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lung Neoplasms; Lymphoma, B-Cell; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

1999
10-Formyl-dihydrofolic acid is bioactive in human leukemia cells.
    The Journal of nutrition, 1999, Volume: 129, Issue:7

    Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Hematinics; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured

1999
Glioblastoma multiforme following prophylactic cranial irradiation and intrathecal methotrexate in a child with acute lymphoblastic leukaemia : a case report.
    Neurology India, 1999, Volume: 47, Issue:2

    Topics: Antimetabolites, Antineoplastic; Child; Glioblastoma; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy

1999
Rapid infusion of high-dose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphomas.
    Journal of neurosurgery, 1999, Volume: 91, Issue:2

    Topics: Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Brain Neoplasms; Chi-Square Distribution; Cranial Irradiation; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Karnofsky Performance Status; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Remission Induction; Survival Rate; Treatment Outcome

1999
Toxic epidermal necrolysis and graft vs. host disease: a clinical spectrum but a diagnostic dilemma.
    Clinical and experimental dermatology, 1999, Volume: 24, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Diagnosis, Differential; Diarrhea; Fatal Outcome; Fever; Graft vs Host Disease; Humans; Liver Failure; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Platelet Transfusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency; Stevens-Johnson Syndrome

1999
Intrathecal methotrexate-induced megaloblastic anemia in patients with acute leukemia.
    Archives of pathology & laboratory medicine, 1999, Volume: 123, Issue:9

    Topics: Adult; Anemia, Megaloblastic; Antimetabolites, Antineoplastic; Female; Folic Acid; Humans; Injections, Spinal; Leukemia, Myelomonocytic, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

1999
Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.
    Pediatric neurology, 1999, Volume: 21, Issue:2

    Topics: Antimetabolites, Antineoplastic; Cerebrospinal Fluid; Child, Preschool; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Paresis; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Nerve Roots

1999
Wilms' tumour gene (wt1) expression at diagnosis has no prognostic relevance in childhood acute lymphoblastic leukaemia treated by an intensive chemotherapy protocol.
    European journal of haematology, 1999, Volume: 63, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; DNA-Binding Proteins; Female; Gene Expression Regulation, Leukemic; Genes, Wilms Tumor; Humans; Life Tables; Male; Mercaptopurine; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Transcription Factors; Vincristine; WT1 Proteins

1999
Children with acute lymphoblastic leukemia who receive T-cell-depleted HLA mismatched marrow allografts from unrelated donors have an increased incidence of primary graft failure but a similar overall transplant outcome.
    Blood, 1999, Oct-01, Volume: 94, Issue:7

    Topics: Adolescent; Antibodies, Monoclonal; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Disease-Free Survival; Female; Histocompatibility Testing; HLA-C Antigens; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Infant; Living Donors; Lymphocyte Depletion; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors; Survival Analysis; T-Lymphocytes; Time Factors; Transplantation, Homologous; Treatment Failure; Treatment Outcome

1999
Defining the optimal dosage of methotrexate for childhood acute lymphoblastic leukemia. New insights from the lab and clinic.
    Advances in experimental medicine and biology, 1999, Volume: 457

    Topics: Antimetabolites, Antineoplastic; Child; Dose-Response Relationship, Drug; Humans; Methotrexate; Ploidies; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1999
Lack of cross-resistance between prednisolone and methotrexate in childhood acute lymphoblastic leukemia? A preliminary analysis.
    Advances in experimental medicine and biology, 1999, Volume: 457

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Child; Cryopreservation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Tumor Cells, Cultured

1999
Prediction of methotrexate elimination after high dose infusion in children with acute lymphoblastic leukaemia using a population pharmacokinetic approach.
    Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bayes Theorem; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Retrospective Studies; Time Factors

1999
Retinoblastoma with acute lymphoblastic leukemia, polyposis coli, and multiple hamartomas.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 1998, Volume: 2, Issue:6

    Topics: Adenomatous Polyposis Coli; Antimetabolites, Antineoplastic; Barium Sulfate; Child, Preschool; Enema; Glucocorticoids; Hamartoma Syndrome, Multiple; Humans; Male; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography; Retinal Neoplasms; Retinoblastoma

1998
Venipuncture versus central venous access: a comparison of methotrexate levels in pediatric leukemia patients.
    Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses, 1999, Volume: 16, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Catheterization, Central Venous; Child; Child, Preschool; Evaluation Studies as Topic; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Phlebotomy; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1999
[Acute leukemia in Jehovah's Witnesses].
    Sangre, 1999, Volume: 44, Issue:5

    Topics: Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blood Transfusion; Christianity; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Fatal Outcome; Female; Humans; Male; Mercaptopurine; Methotrexate; Personnel, Hospital; Physician-Patient Relations; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Refusal to Treat; Remission Induction; Right to Die; Treatment Refusal; Vincristine

1999
Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells.
    Biochemical pharmacology, 2000, Feb-15, Volume: 59, Issue:4

    Topics: Adenine; Antimetabolites, Antineoplastic; Child; Guanine; Humans; Inosine; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured

2000
A magnetic resonance abnormality correlating with permeability of the blood-brain barrier in a child with chemical meningitis during central nervous system prophylaxis for acute leukemia.
    Annals of hematology, 1999, Volume: 78, Issue:12

    Topics: Albumins; alpha-Macroglobulins; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Cell Membrane Permeability; Child, Preschool; Humans; Immunoglobulin G; Injections, Spinal; Magnetic Resonance Imaging; Male; Meningitis; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1999
Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia.
    Blood, 2000, Feb-01, Volume: 95, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Gene Rearrangement; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk; Time Factors; Treatment Outcome; Vincristine

2000
Cerebral glucose metabolism in survivors of childhood acute lymphoblastic leukemia.
    Cancer, 2000, Feb-01, Volume: 88, Issue:3

    Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Attention; Brain; Brain Diseases; Brain Neoplasms; Child; Cranial Irradiation; Female; Fluorodeoxyglucose F18; Glucose; Humans; Leukocyte Count; Male; Mental Processes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Radiation Injuries; Radiopharmaceuticals; Radiotherapy Dosage; Survivors; Tomography, Emission-Computed

2000
Individualized methotrexate dosing in children with relapsed acute lymphoblastic leukemia.
    Leukemia, 2000, Volume: 14, Issue:2

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2000
[The efficacy of BFM-90 program in the treatment of acute lymphoblastic leukemia in children in the studies of Polish pediatric leukemia/lymphoma group].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1998, Volume: 51 Suppl 4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Treatment Outcome; Vincristine

1998
[The analysis of failures in the treatment of children with non-B non-Hodgkin's lymphoma. Polish pediatric leukemia/lymphoma study group report].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1998, Volume: 51 Suppl 4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Follow-Up Studies; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Neoplasm Staging; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Treatment Failure; Vincristine

1998
Variability in methotrexate serum and cerebrospinal fluid pharmacokinetics in children with acute lymphocytic leukemia: relation to assay methodology and physiological variables.
    Leukemia research, 2000, Volume: 24, Issue:3

    Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychological Techniques

2000
Cutaneous side effects of medium dose methotrexate in children with acute lymphoblastic leukaemia.
    Medical and pediatric oncology, 2000, Volume: 34, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Drug Eruptions; Eosinophilia; Erythema; Exanthema; Female; Humans; Leg Dermatoses; Male; Methotrexate; Pigmentation Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2000
Intracranial meningioma following childhood irradiation for leukaemia.
    British journal of haematology, 2000, Volume: 108, Issue:4

    Topics: Adult; Antimetabolites, Antineoplastic; Child, Preschool; Cranial Irradiation; Female; Humans; Meningeal Neoplasms; Meningioma; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

2000
Academic career after treatment for acute lymphoblastic leukaemia.
    Archives of disease in childhood, 2000, Volume: 82, Issue:5

    Topics: Adolescent; Adult; Age of Onset; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cranial Irradiation; Education, Special; Educational Status; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Regression Analysis; Retrospective Studies; Risk Factors; Sex Factors; Survivors

2000
Intellectual, neuropsychological, and academic functioning in long-term survivors of leukemia.
    Journal of pediatric psychology, 2000, Volume: 25, Issue:2

    Topics: Achievement; Adolescent; Antineoplastic Agents; Asthma; Brain; Child; Chronic Disease; Cognition Disorders; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Injections, Spinal; Intelligence; Intelligence Tests; Long-Term Care; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Severity of Illness Index; Survivors

2000
Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia.
    British journal of haematology, 2000, Volume: 109, Issue:3

    Topics: B-Lymphocytes; Biological Transport; Cell Membrane; Drug Resistance, Neoplasm; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Neoplastic Stem Cells; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Thymidylate Synthase; Tumor Cells, Cultured

2000
Comparative analysis of methotrexate polyglutamates in lymphoblast preparations from bone marrow and blood, and the contribution of residual red blood cells.
    Journal of cancer research and clinical oncology, 2000, Volume: 126, Issue:7

    Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow; Child; Child, Preschool; Erythrocytes; Female; Humans; Leukemia, Myeloid, Acute; Lymphocytes; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

2000
Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole.
    International journal of dermatology, 2000, Volume: 39, Issue:8

    Topics: Adolescent; Anti-Infective Agents; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Fatal Outcome; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stevens-Johnson Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination

2000
[Carboxypeptidase-G2-rescue in a woman with methotrexate-induced renal failure].
    Medizinische Klinik (Munich, Germany : 1983), 2000, Aug-15, Volume: 95, Issue:8

    Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Creatinine; Female; gamma-Glutamyl Hydrolase; Humans; Infusions, Intravenous; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

2000
Methotrexate treatment protocols and the central nervous system: significant cure with significant neurotoxicity.
    Journal of child neurology, 2000, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Electroencephalography; Female; Humans; Leucovorin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, Emission-Computed, Single-Photon

2000
Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia.
    Blood, 2000, Oct-15, Volume: 96, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Daunorubicin; Etoposide; Female; Flow Cytometry; Humans; Hydrocortisone; Immunophenotyping; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Neoplastic Cells, Circulating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Remission Induction; Treatment Outcome; Vincristine

2000
White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings.
    Medical and pediatric oncology, 2000, Volume: 35, Issue:5

    Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Brain Injuries; Child; Child, Preschool; Cytarabine; Demyelinating Diseases; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiotherapy, Adjuvant; Statistics, Nonparametric

2000
High-dose methotrexate is lethal to rats. Why give it to children?
    Pediatric hematology and oncology, 2000, Volume: 17, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats

2000
Fasting hypoglycemia is common during maintenance therapy for childhood acute lymphoblastic leukemia.
    The Journal of pediatrics, 2001, Volume: 138, Issue:3

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Child; Child, Preschool; Fasting; Female; Finland; Humans; Hypoglycemia; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Statistics, Nonparametric

2001
Motor nervous pathway function is impaired after treatment of childhood acute lymphoblastic leukemia: a study with motor evoked potentials.
    Medical and pediatric oncology, 2001, Volume: 36, Issue:3

    Topics: Adolescent; Antineoplastic Agents; Case-Control Studies; Child; Child, Preschool; Evoked Potentials, Motor; Female; Humans; Male; Methotrexate; Motor Neuron Disease; Neurologic Examination; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2001
Hepatic dysfunction in children with acute lymphoblastic leukemia in remission: relation to hepatitis infection.
    Medical and pediatric oncology, 2001, Volume: 36, Issue:4

    Topics: Antimetabolites, Antineoplastic; Case-Control Studies; Chemical and Drug Induced Liver Injury; Child; Egypt; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Incidence; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Saudi Arabia

2001
Reversal of neurologic disturbances related to high-dose methotrexate by aminophylline.
    Medical and pediatric oncology, 2001, Volume: 36, Issue:6

    Topics: Aminophylline; Antimetabolites, Antineoplastic; Child; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency

2001
Preliminary experience with a new chemotherapy regimen for adults with acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2001, Volume: 41, Issue:3-4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Cyclophosphamide; Cytogenetic Analysis; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2001
The history of folic acid.
    British journal of haematology, 2001, Volume: 113, Issue:3

    Topics: Anemia; Brain Diseases; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; History, 20th Century; Humans; Hyperhomocysteinemia; Methotrexate; Neural Tube Defects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications, Hematologic; Vascular Diseases; Vitamin B 12 Deficiency

2001
Early onset Pneumocystis carinii pneumonia after allogeneic peripheral blood stem cell transplantation.
    American journal of hematology, 2001, Volume: 67, Issue:3

    Topics: Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cytarabine; Daunorubicin; Etoposide; Fatal Outcome; Hematopoietic Stem Cell Transplantation; Humans; Immune System; Immunocompromised Host; Male; Methotrexate; Middle Aged; Opportunistic Infections; Pneumonia, Pneumocystis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Respiratory Insufficiency; Transplantation Conditioning; Transplantation, Autologous; Trimethoprim, Sulfamethoxazole Drug Combination; Vincristine; Whole-Body Irradiation

2001
Long-term cerebral metabolite changes on proton magnetic resonance spectroscopy in patients cured of acute lymphoblastic leukemia with previous intrathecal methotrexate and cranial irradiation prophylaxis.
    International journal of radiation oncology, biology, physics, 2001, Jul-01, Volume: 50, Issue:3

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Aspartic Acid; Brain; Brain Infarction; Cerebrovascular Disorders; Child; Choline; Cranial Irradiation; Creatine; Female; Humans; Injections, Spinal; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Time Factors

2001
Magnetic resonance imaging detection of avascular necrosis of the bone in children receiving intensive prednisone therapy for acute lymphoblastic leukemia or non-Hodgkin lymphoma.
    Leukemia, 2001, Volume: 15, Issue:6

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Arthralgia; Arthroplasty, Replacement, Hip; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Female; Femur Head Necrosis; Humans; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Treatment Outcome; Vincristine

2001
High level resistance to glucocorticoids, associated with a dysfunctional glucocorticoid receptor, in childhood acute lymphoblastic leukemia cells selected for methotrexate resistance.
    Leukemia, 2001, Volume: 15, Issue:6

    Topics: Active Transport, Cell Nucleus; Alleles; Antineoplastic Agents; Child; Cytarabine; Dexamethasone; DNA Mutational Analysis; DNA, Neoplasm; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glucocorticoids; Humans; Leukemia, T-Cell; Methotrexate; Neoplasm Proteins; Neoplastic Stem Cells; Polymorphism, Restriction Fragment Length; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Receptors, Glucocorticoid; RNA, Messenger; RNA, Neoplasm; Selection, Genetic; Sequence Analysis, DNA; Tumor Cells, Cultured

2001
Delay of the diagnostic lumbar puncture and intrathecal chemotherapy in children with acute lymphoblastic leukemia who undergo routine corticosteroid testing: Tokyo Children's Cancer Study Group study L89-12.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Jul-01, Volume: 19, Issue:13

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Drug Screening Assays, Antitumor; Female; Follow-Up Studies; Glucocorticoids; Humans; Infant; Injections, Spinal; Japan; Life Tables; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Proportional Hazards Models; Risk; Sensitivity and Specificity; Spinal Puncture; Time Factors; Treatment Outcome

2001
The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
    Leukemia, 2001, Volume: 15, Issue:7

    Topics: Child; Child, Preschool; Core Binding Factor Alpha 2 Subunit; Female; Humans; Infant; Lymphocytes; Male; Methotrexate; Oncogene Proteins, Fusion; Ploidies; Polyglutamic Acid; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Translocation, Genetic

2001
Long-term effects on the intelligence of children treated for acute lymphoblastic leukemia.
    Cancer investigation, 2001, Volume: 19, Issue:6

    Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Follow-Up Studies; Humans; Intelligence; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Recurrence; Survivors; Time Factors; Wechsler Scales

2001
Repeated achilles tendinitis after high dose methotrexate.
    Medical and pediatric oncology, 2001, Volume: 37, Issue:2

    Topics: Achilles Tendon; Adolescent; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk Factors; Tendinopathy

2001
[Treatment of acute lymphoblastic leukemia in adults as an unsolved problem].
    Terapevticheskii arkhiv, 2001, Volume: 73, Issue:7

    Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Dexamethasone; Humans; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Time Factors; Vincristine

2001
Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnormalities after allogeneic bone marrow transplantation.
    International journal of hematology, 2001, Volume: 74, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Clone Cells; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; DNA Damage; Female; Follow-Up Studies; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Mercaptopurine; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Time Factors; Transplantation Conditioning; Transplantation, Homologous; Vincristine

2001
Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment.
    Archives of disease in childhood, 2001, Volume: 85, Issue:4

    Topics: Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Clinical Trials as Topic; Cytogenetic Analysis; Disease-Free Survival; Down Syndrome; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Infant; Male; Methotrexate; Patient Selection; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Survival Rate

2001
MR findings in Balint's syndrome, following intrathecal methotrexate and cytarabine therapy in adult acute lymphoblastic leukemia.
    European neurology, 2001, Volume: 46, Issue:3

    Topics: Adult; Brain; Cytarabine; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Neurologic Examination; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Disorders; Syndrome

2001
Prognostic impact of CD45 antigen expression in high-risk, childhood B-cell precursor acute lymphoblastic leukemia.
    Leukemia & lymphoma, 2001, Volume: 42, Issue:3

    Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Child; Disease-Free Survival; Doxorubicin; Humans; Immunophenotyping; Leukocyte Common Antigens; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Time Factors; Vincristine

2001
Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:11

    Topics: Amino Acid Substitution; B-Lymphocytes; Base Sequence; Biological Transport; Carrier Proteins; Child; DNA Mutational Analysis; DNA, Complementary; DNA, Neoplasm; Gene Frequency; Humans; K562 Cells; Membrane Transport Proteins; Methotrexate; Mutagenesis, Insertional; Plasmids; Point Mutation; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; RNA, Neoplasm; Stem Cells; Transfection

2001
Report of a patient with a high level of parathyroid hormone-related peptide associated with malignant lymphoma involving multiple bony lesions.
    Nephron, 2002, Volume: 90, Issue:1

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Hypercalcemia; Kidney; Methotrexate; Parathyroid Hormone-Related Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteins

2002
Ventral polyradiculopathy with pediatric acute lymphocytic leukemia.
    Muscle & nerve, 2002, Volume: 25, Issue:1

    Topics: Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cytarabine; Electromyography; Female; Humans; Hydrocortisone; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2002
Adult lymphoblastic lymphoma in Taiwan: an analysis of treatment results of 26 patients.
    Annals of hematology, 2001, Volume: 80, Issue:11

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Cyclophosphamide; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Mechlorethamine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Procarbazine; Prognosis; Recurrence; Retrospective Studies; Survival Analysis; Taiwan; Treatment Outcome; Vincristine

2001
Late effects of anticancer therapy on kidney function in children with acute lymphoblastic leukemia.
    Bratislavske lekarske listy, 2001, Volume: 102, Issue:8

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Kidney; Kidney Function Tests; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

2001
Thiopurine methyl transferase: activity and genotyping in patients with acute lymphoblastic leukemia.
    Advances in experimental medicine and biology, 2000, Volume: 486

    Topics: Alleles; Antimetabolites, Antineoplastic; Child; Female; Genetic Testing; Genotype; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2000
[Effective treatment with Lamivudine of patients with reactivation of hepatitis B following chemotherapy administration].
    Harefuah, 2001, Volume: 140, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Reverse Transcriptase Inhibitors; Vincristine; Virus Activation

2001
Toxic epidermal necrolysis in a girl with leukemia receiving methotrexate.
    Indian pediatrics, 2001, Volume: 38, Issue:4

    Topics: Child; Female; Follow-Up Studies; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Assessment; Severity of Illness Index; Stevens-Johnson Syndrome

2001
Effect of methotrexate polyglutamates on thioguanine nucleotide concentrations during continuation therapy of acute lymphoblastic leukemia with mercaptopurine.
    Leukemia, 2002, Volume: 16, Issue:2

    Topics: Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Child; Drug Administration Schedule; Erythrocytes; Humans; Hypoxanthine Phosphoribosyltransferase; Inactivation, Metabolic; Injections, Intravenous; Inosine Monophosphate; Mercaptopurine; Methotrexate; Methyltransferases; Neoplasm Proteins; Nucleotides; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Thioguanine; Thionucleotides; Xanthine Oxidase

2002
Massive haemolysis in a group A recipient of a group O peripheral blood stem cell allogeneic transplant.
    Transfusion medicine (Oxford, England), 2001, Volume: 11, Issue:6

    Topics: ABO Blood-Group System; Adult; B-Lymphocytes; Blood Cells; Blood Donors; Blood Group Incompatibility; Hematopoietic Stem Cell Transplantation; Hemolysis; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rh-Hr Blood-Group System; Transplantation Immunology; Transplantation, Homologous

2001
Childhood acute lymphoblastic leukemia: prognostic value of initial peripheral blast count in good responders to prednisone.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Child; Child, Preschool; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Infant; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Survival Rate; Treatment Outcome

2001
Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia.
    Pediatric hematology and oncology, 2002, Volume: 19, Issue:2

    Topics: Adolescent; Antimetabolites, Antineoplastic; Humans; Kidney Diseases; Leucovorin; Male; Methotrexate; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radioisotope Renography

2002
Chemotherapy related fatal neurotoxicity during induction in acute lymphoblastic leukemia.
    Indian journal of pediatrics, 2002, Volume: 69, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Dexamethasone; Fatal Outcome; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

2002
Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia.
    Lancet (London, England), 2002, Mar-23, Volume: 359, Issue:9311

    Topics: Child; Humans; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase; Treatment Outcome; Trinucleotide Repeats

2002
Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia.
    Leukemia, 2002, Volume: 16, Issue:4

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; DNA, Neoplasm; Drug Resistance; Genotype; Heterozygote; Homozygote; Humans; Infant; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2002
Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999.
    British journal of haematology, 2002, Volume: 117, Issue:2

    Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Central Nervous System Diseases; Chi-Square Distribution; Disease-Free Survival; Female; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Injections, Spinal; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Survival Rate; United Kingdom

2002
CNS late-effects after ALL therapy in childhood. Part III: neuropsychological performance in long-term survivors of childhood ALL: impairments of concentration, attention, and memory.
    Medical and pediatric oncology, 2002, Volume: 38, Issue:5

    Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Attention; Brain Neoplasms; Central Nervous System; Child; Child, Preschool; Cognition Disorders; Cranial Irradiation; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Intelligence Tests; Male; Memory Disorders; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

2002
Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistance.
    Leukemia, 2002, Volume: 16, Issue:5

    Topics: Antimetabolites, Antineoplastic; Blood Cells; Bone Marrow Cells; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Infant; Infant, Newborn; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2002
No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: a prospective longitudinal study.
    Journal of pediatric hematology/oncology, 2002, Volume: 24, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Attention; Child, Preschool; Cognition Disorders; Cyclophosphamide; Cytarabine; Dexamethasone; Female; Follow-Up Studies; Humans; Ifosfamide; Injections, Spinal; Learning Disabilities; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; Netherlands; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Survivors; Teniposide; Treatment Outcome; Vincristine

2002
Pediatric acute lymphoblastic leukemia: redefining outcomes.
    Journal of pediatric hematology/oncology, 2002, Volume: 24, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Attention; Child; Child, Preschool; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Dexamethasone; Drug Administration Routes; Humans; Hydrocortisone; Infant; Learning Disabilities; Memory Disorders; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survivors; Treatment Outcome

2002
Expression of P53 and bcl-2 proteins in T-cell lymphoblastic lymphoma: prognostic implications.
    Leukemia & lymphoma, 2002, Volume: 43, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Disease-Free Survival; Etoposide; Female; Humans; Ifosfamide; Immunohistochemistry; Logistic Models; Longitudinal Studies; Male; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proto-Oncogene Proteins c-bcl-2; Recurrence; Retrospective Studies; Survival Analysis; Tumor Suppressor Protein p53; Vincristine

2002
CD56 expression predicts occurrence of CNS disease in acute lymphoblastic leukemia.
    Leukemia research, 2002, Volume: 26, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Marrow Cells; CD56 Antigen; Cell Adhesion; Central Nervous System; Chemotaxis, Leukocyte; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Gene Expression; Humans; Incidence; Leukemic Infiltration; Life Tables; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm Proteins; Neoplastic Stem Cells; Neurons; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Risk; Survival Analysis; Treatment Outcome; Vincristine

2002
Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, May-15, Volume: 20, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Administration Schedule; Etoposide; Female; Humans; Immunophenotyping; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Treatment Outcome; Vincristine

2002
[High risk acute lymphoblastic leukaemia in children. Preliminary report after introducing a new version of New York (1997) protocol adjusted to the age of the patients. Report of the Polish Paediatric Leukaemia/Lymphoma Study Group].
    Medycyna wieku rozwojowego, 2000, Volume: 4, Issue:1 Suppl 2

    Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Multicenter Studies as Topic; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Retrospective Studies; Risk Factors; Thioguanine; Time Factors; Treatment Outcome; Vincristine

2000
Radiation myelitis in a 5-year-old girl.
    Journal of child neurology, 2002, Volume: 17, Issue:3

    Topics: Child, Preschool; Chronic Disease; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methotrexate; Muscle, Skeletal; Myelitis; Necrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Dosage; Radiation Injuries; Radiculopathy; Radiotherapy

2002
Urate-oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia, treated in the Société Française d'Oncologie Pédiatrique LMB89 protocol.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2002, Volume: 13, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; France; Humans; Hydrocortisone; Leucovorin; Lymphoma, B-Cell; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Survival Rate; Treatment Outcome; Tumor Lysis Syndrome; Urate Oxidase; Vincristine

2002
Complications of tumour overkill when associated with high dose methotrexate therapy.
    Clinical and experimental pharmacology & physiology. Supplement, 1979, Volume: 5

    Topics: Adolescent; Adult; Calcium; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Phosphates; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1979
Cytomegalovirus infection in children with blood diseases.
    Acta haematologica Polonica, 1992, Volume: 23, Issue:3

    Topics: Adolescent; Anemia, Aplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Cytomegalovirus Infections; Daunorubicin; Female; gamma-Globulins; Humans; Immune Tolerance; Immunization, Passive; Infant; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Thioguanine; Vincristine

1992
Bone marrow necrosis and human parvovirus associated infection preceding an Ph1+ acute lymphoblastic leukemia.
    Leukemia & lymphoma, 1992, Volume: 8, Issue:4-5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cyclophosphamide; Daunorubicin; Erythema Infectiosum; Female; Humans; Karyotyping; Methotrexate; Pancytopenia; Parvovirus B19, Human; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Steroids; Vincristine

1992
Analyses of salivary components in leukemia patients receiving chemotherapy.
    Oral surgery, oral medicine, and oral pathology, 1992, Volume: 73, Issue:1

    Topics: Adolescent; Adult; Aged; Amylases; Analysis of Variance; Antibiotics, Antineoplastic; Antineoplastic Agents; Child; Chlorhexidine; Cyclophosphamide; Female; Granulocytes; Humans; Immunoglobulin A, Secretory; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Methotrexate; Middle Aged; Peroxidases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Saliva; Salivary Proteins and Peptides; Secretory Rate; Thiocyanates; Vincristine

1992
Impairment of cerebral biogenic amine synthesis in a patient receiving high-dose methotrexate.
    The American journal of pediatric hematology/oncology, 1992, Volume: 14, Issue:3

    Topics: Adolescent; Biogenic Amines; Biopterins; Brain; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1992
Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia.
    Blood, 1992, Sep-01, Volume: 80, Issue:5

    Topics: Adolescent; Adult; Aged; Biological Transport; Child; Child, Preschool; Drug Resistance; Female; Humans; Infant; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Trimetrexate; Tumor Cells, Cultured

1992
Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study.
    Blood, 1992, Sep-01, Volume: 80, Issue:5

    Topics: Child; Child, Preschool; Chromosome Aberrations; Diploidy; Female; Humans; Infant; Lymphocytes; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S Phase

1992
[Treatment of elderly patients with hematological malignancies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:11

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Etoposide; Hodgkin Disease; Humans; Leucovorin; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Methotrexate; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Vincristine

1992
Etoposide, ifosfamide, and methotrexate combination chemotherapy for aggressive non-Hodgkin's lymphomas after failure of the LNH 84 regimen.
    Seminars in oncology, 1992, Volume: 19, Issue:1 Suppl 1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow; Cyclophosphamide; Doxorubicin; Etoposide; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Salvage Therapy; Vindesine

1992
Substitutive therapy in a case of methotrexate neurotoxicity.
    European journal of cancer (Oxford, England : 1990), 1992, Volume: 28A, Issue:11

    Topics: Brain Diseases; Child, Preschool; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1992
Transient neurologic disturbances in a child treated with moderate-dose methotrexate.
    British journal of haematology, 1992, Volume: 81, Issue:3

    Topics: Brain; Cerebrovascular Disorders; Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

1992
Relation of 5'-nucleotidase and phosphatase activities with immunophenotype, drug resistance and clinical prognosis in childhood leukemia.
    Leukemia research, 1992, Volume: 16, Issue:9

    Topics: 5'-Nucleotidase; Acid Phosphatase; Adolescent; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Daunorubicin; Drug Resistance; Female; Humans; Immunophenotyping; Infant; Leukemia, B-Cell; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Vincristine

1992
White matter changes in children treated for acute lymphoblastic leukemia.
    Cancer, 1992, Dec-01, Volume: 70, Issue:11

    Topics: Adolescent; Adult; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy

1992
Effect of high-dose methotrexate on plasma hypoxanthine and uridine levels in patients with acute leukemia or non-Hodgkin lymphoma in childhood.
    Leukemia, 1992, Volume: 6, Issue:11

    Topics: Adolescent; Child; Humans; Hypoxanthine; Hypoxanthines; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Uridine

1992
N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
    The Mount Sinai journal of medicine, New York, 1992, Volume: 59, Issue:5

    Topics: Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured

1992
[Burgdorf's reaction (painful acral erythema) in patients with acute lymphoblastic leukemia following medium-dose methotrexate therapy].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1992, Volume: 45, Issue:11-12

    Topics: Child, Preschool; Dose-Response Relationship, Drug; Erythema; Female; Hand Dermatoses; Humans; Infusions, Intravenous; Male; Methotrexate; Pain; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1992
Pattern of 6-mercaptopurine urinary excretion in children with acute lymphoblastic leukemia: urinary assays as a measure of drug compliance.
    Therapeutic drug monitoring, 1992, Volume: 14, Issue:5

    Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Circadian Rhythm; Drug Administration Schedule; Humans; Mercaptopurine; Methotrexate; Patient Compliance; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1992
A comparison of neuropsychological and psychosocial functioning after prophylactic treatment for childhood leukemia in monozygotic twins.
    The American journal of pediatric hematology/oncology, 1992, Volume: 14, Issue:4

    Topics: Affective Symptoms; Attention; Child; Female; Humans; Injections, Spinal; Language Tests; Leukemic Infiltration; Memory; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Twins, Monozygotic; Verbal Learning; Wechsler Scales

1992
The BFM-protocol for HIV-negative Burkitt's lymphomas and L3 ALL in adult patients: a high chance for cure.
    Annals of hematology, 1992, Volume: 65, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Diseases; Female; HIV Seropositivity; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction

1992
Chronopharmacology of methotrexate pharmacokinetics in childhood leukemia.
    Chronobiology international, 1992, Volume: 9, Issue:6

    Topics: Child; Child, Preschool; Circadian Rhythm; Drug Administration Schedule; Female; Humans; Kidney; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1992
Analysis of growth failure in children treated for acute lymphoblastic leukemia.
    International journal of hematology, 1992, Volume: 56, Issue:3

    Topics: Adolescent; Anthropometry; Antineoplastic Combined Chemotherapy Protocols; Body Height; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Growth Disorders; Humans; Incidence; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Puberty, Delayed; Radiation Injuries; Remission Induction; Risk Factors

1992
[Studies of methotrexate pharmacokinetics in children with neoplasms of the hematopoietic system after administration of different doses of the drug].
    Acta haematologica Polonica, 1992, Volume: 23, Issue:3

    Topics: Administration, Oral; Adolescent; Age Factors; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Half-Life; Humans; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

1992
[Cerebrospinal fluid methotrexate level in children treated with medium-high and high doses of the drug].
    Acta haematologica Polonica, 1992, Volume: 23, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

1992
Therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with acute lymphoblastic leukemia.
    Medical hypotheses, 1992, Volume: 39, Issue:4

    Topics: Brain Neoplasms; Child; Combined Modality Therapy; Humans; Intelligence; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Radiotherapy Dosage; Survival Analysis

1992
Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate.
    Cancer, 1992, Oct-01, Volume: 70, Issue:7

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Central Nervous System Neoplasms; Cerebral Cortex; Child; Child, Preschool; Female; Humans; Injections, Intravenous; Injections, Spinal; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies

1992
Management of children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols. An update of the Ontario experience.
    The American journal of pediatric hematology/oncology, 1992, Volume: 14, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cohort Studies; Cranial Irradiation; Cytarabine; Daunorubicin; Doxorubicin; Humans; Infant; Life Tables; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Risk; Survival Analysis; Survival Rate; Treatment Outcome; Vincristine

1992
[Analysis of lymphocyte surface markers in childhood acute lymphoblastic leukemia during maintenance chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:5

    Topics: Antigens, Surface; Antineoplastic Combined Chemotherapy Protocols; CD4-CD8 Ratio; Child; HLA-DR Antigens; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Interleukin-2; Remission Induction; T-Lymphocyte Subsets

1992
Comparison of a new high-performance liquid chromatography method with fluorescence polarization immunoassay for analysis of methotrexate.
    Therapeutic drug monitoring, 1992, Volume: 14, Issue:2

    Topics: Child; Chromatography, High Pressure Liquid; Fluorescence Polarization Immunoassay; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Spectrophotometry, Ultraviolet

1992
Rational use of methotrexate in maintenance therapy of childhood acute lymphoblastic leukemia.
    Chinese medical journal, 1992, Volume: 105, Issue:2

    Topics: Administration, Oral; Animals; Biological Availability; Child; Humans; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Rats, Inbred Strains

1992
Cerebrospinal fluid exchange after intrathecal methotrexate overdose. A report of two cases.
    Acta paediatrica (Oslo, Norway : 1992), 1992, Volume: 81, Issue:4

    Topics: Cerebrospinal Fluid; Child; Child, Preschool; Drug Overdose; Humans; Injections, Spinal; Male; Medication Errors; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sodium Chloride; Spinal Puncture

1992
Cranial computed tomographic findings in children with newly diagnosed acute lymphoblastic leukemia: a prospective follow-up study during treatment.
    Medical and pediatric oncology, 1992, Volume: 20, Issue:4

    Topics: Adolescent; Brain; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Tomography, X-Ray Computed

1992
An HIV positive haemophiliac with acute lymphoblastic leukaemia successfully treated with intensive chemotherapy and syngeneic bone marrow transplantation.
    Bone marrow transplantation, 1992, Volume: 9, Issue:5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Hemophilia A; HIV Seropositivity; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1992
[Late recurrence (11 years) in a case of ALL. Recurrence or a second disease?].
    Sangre, 1992, Volume: 37, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Diagnosis, Differential; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Time Factors; Vincristine

1992
Use of a synthetic protease inhibitor for the treatment of L-asparaginase-induced acute pancreatitis complicated by disseminated intravascular coagulation.
    Annals of hematology, 1992, Volume: 64, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamidines; Cyclophosphamide; Disseminated Intravascular Coagulation; Female; Gabexate; Guanidines; Humans; Male; Methotrexate; Pancreatitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Protease Inhibitors; Vincristine

1992
Serum methotrexate in childhood ALL.
    British journal of cancer, 1992, Volume: 66, Issue:1

    Topics: Child; Half-Life; Humans; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome

1992
Maintenance chemotherapy and cure of childhood acute lymphoblastic leukaemia.
    Lancet (London, England), 1991, Nov-23, Volume: 338, Issue:8778

    Topics: Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bone Marrow; Child; Humans; Long-Term Care; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis

1991
A human leukemia cell line made resistant to two folate analogues, trimetrexate and N10-propargyl-5,8-dideazafolic acid (CB3717).
    Journal of cancer research and clinical oncology, 1991, Volume: 117, Issue:6

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Cisplatin; Cross Reactions; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Fluorouracil; Folic Acid; Humans; Leucovorin; Membrane Glycoproteins; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; RNA, Messenger; Thymidylate Synthase; Trimetrexate; Vincristine

1991
Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis.
    Blood, 1990, Jul-01, Volume: 76, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Lymphocytes; Male; Methotrexate; Peptides; Pilot Projects; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

1990
Intensive chemotherapy for adult lymphoblastic lymphomas.
    Cancer chemotherapy and pharmacology, 1991, Volume: 29, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine

1991
Enhancement of etoposide and methotrexate sensitivity by indomethacin in vitro.
    Anti-cancer drug design, 1991, Volume: 6, Issue:5

    Topics: Animals; Bleomycin; Drug Synergism; Etoposide; Humans; Indomethacin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lipoxygenase Inhibitors; Lung Neoplasms; Lymphoma; Methotrexate; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostaglandins; Protein Kinase Inhibitors; Tumor Cells, Cultured

1991
Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia.
    Leukemia research, 1991, Volume: 15, Issue:12

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Resistance; Humans; Infant; Leukemia, Myeloid, Acute; Methotrexate; Middle Aged; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured

1991
Behavioral effects of corticosteroids in children with acute lymphoblastic leukemia.
    Medical and pediatric oncology, 1992, Volume: 20, Issue:1

    Topics: Age Factors; Analysis of Variance; Attention; Child; Child Behavior; Child, Preschool; Cytarabine; Depression; Doxorubicin; Drug Interactions; Emotions; Female; Humans; Infant; Interpersonal Relations; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Sex Factors; Sleep; Vincristine

1992
Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia.
    Journal of the National Cancer Institute, 1992, Feb-19, Volume: 84, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Etoposide; Female; Humans; Infant; Leucovorin; Male; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1992
Results of the LMT81 protocol, a modified LSA2L2 protocol with high dose methotrexate, on 84 children with non-B-cell (lymphoblastic) lymphoma.
    Medical and pediatric oncology, 1992, Volume: 20, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Drug Administration Schedule; Female; Humans; Infant; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Vincristine

1992
Isolated breast relapse after allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia.
    Medical and pediatric oncology, 1992, Volume: 20, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Child; Female; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

1992
[The analysis of leukemic relapse after allogeneic bone marrow transplantation].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1991, Volume: 32, Issue:11

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Cyclosporine; Female; Graft vs Host Disease; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Postoperative Complications; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Transplantation, Homologous

1991
[Clinical evaluation of severe toxicity in two patients with acute lymphoblastic leukemia receiving outpatient methotrexate therapy].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1991, Volume: 32, Issue:11

    Topics: Acute Kidney Injury; Bone Marrow; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1991
[Treatment of acute lymphoblastic leukemia in children according to the Berlin-Frankfurt-Münster Program].
    Pediatriia, 1991, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Humans; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Time Factors

1991
Aminoterminal propeptide of type III procollagen in cerebrospinal fluid. Variation with age and in childhood leukemia.
    Clinica chimica acta; international journal of clinical chemistry, 1991, Nov-09, Volume: 203, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Peptide Fragments; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Procollagen; Radioimmunoassay

1991
[Early neurotoxicity of high-dose of methotrexate and tetrahydrobiopterin deficiency].
    Archives francaises de pediatrie, 1991, Volume: 48, Issue:10

    Topics: Biopterins; Child; Humans; Male; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1991
Decrease in number of CD16(Leu 11)+CD45RA(2H4)+ cells and defective production of natural killer cytotoxic factor in childhood acute lymphoblastic leukemia.
    Leukemia research, 1991, Volume: 15, Issue:9

    Topics: Adult; Antigens, CD; Antigens, Differentiation; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; CD8 Antigens; Child; Cytotoxicity, Immunologic; Dexamethasone; Flow Cytometry; Histocompatibility Antigens; HLA-DR Antigens; Humans; Killer Cells, Natural; Killer Factors, Yeast; Leukocyte Common Antigens; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Protein Biosynthesis; Proteins; Receptors, Fc; Receptors, IgG; Vincristine

1991
Schedule-dependent synergism and antagonism between methotrexate and 6-mercaptopurine in a human acute lymphoblastic cell line.
    European journal of cancer (Oxford, England : 1990), 1991, Volume: 27, Issue:9

    Topics: Cell Division; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

1991
[The fate of children after discontinuation of treatment for acute lymphoblastic leukemia].
    Acta haematologica Polonica, 1991, Volume: 22, Issue:2

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Infant; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Sex Factors; Time Factors; Vincristine

1991
Skin manifestation of extramedullary relapse in adult with acute lymphoblastic leukaemia.
    Haematologia, 1991, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Immunotherapy; Leukemic Infiltration; Mercaptopurine; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiotherapy; Recurrence; Remission Induction; Skin; Vincristine

1991
Immunization response varies with intensity of acute lymphoblastic leukemia therapy.
    American journal of diseases of children (1960), 1991, Volume: 145, Issue:8

    Topics: Antibodies, Bacterial; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Capsules; Bacterial Vaccines; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Diphtheria Antitoxin; Diphtheria Toxoid; Diphtheria-Tetanus Vaccine; Drug Combinations; Female; Haemophilus influenzae; Haemophilus Vaccines; Humans; Immunization; Immunization, Secondary; Male; Methotrexate; Polysaccharides, Bacterial; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Tetanus Antitoxin; Tetanus Toxoid; Vincristine

1991
Carboxyterminal propeptide of type I procollagen in cerebrospinal fluid in childhood and in children with leukemia undergoing intrathecal treatment.
    Clinical chemistry, 1991, Volume: 37, Issue:8

    Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Peptides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Procollagen

1991
Priapism in a child with acute lymphoblastic leukemia.
    Acta paediatrica Scandinavica, 1991, Volume: 80, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Humans; Male; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Priapism; Remission Induction; Vincristine

1991
Treatment of adult acute lymphoblastic leukemia with allogeneic bone marrow transplantation. Multivariate analysis of factors affecting acute graft-versus-host disease, relapse, and relapse-free survival.
    Bone marrow transplantation, 1991, Volume: 7, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Bone Marrow Transplantation; Cyclosporins; Female; Graft vs Host Disease; Histocompatibility; HLA Antigens; Humans; Incidence; Male; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Homologous

1991
2,4-diamino-7-hydroxy-pteridines, a new class of catabolites of methotrexate.
    European journal of biochemistry, 1991, Aug-15, Volume: 200, Issue:1

    Topics: Adolescent; Adult; Animals; Biotransformation; Child; Child, Preschool; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hodgkin Disease; Humans; Liver; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pteridines; Rabbits; Rats

1991
The F-MACHOP regimen in advanced diffuse aggressive lymphomas: summary of ten years' experience at a single institution.
    Leukemia, 1991, Volume: 5 Suppl 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Fluorouracil; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

1991
Cognitive function in children with leukemia. Effect of radiation dose and time since irradiation.
    Cancer, 1991, Nov-01, Volume: 68, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Child; Child, Preschool; Cognition; Combined Modality Therapy; Cranial Irradiation; Educational Status; Female; Humans; Infant; Intelligence; Male; Methotrexate; Motor Skills; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Remission Induction; Time Factors

1991
Secondary acute non-lymphocytic leukemia with monosomy 7 arising 9 years after acute lymphoblastic leukemia in childhood.
    Cancer genetics and cytogenetics, 1991, Volume: 55, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Preschool; Chromosomes, Human, Pair 7; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Methotrexate; Monosomy; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy

1991
Raised plasma methotrexate concentrations following intrathecal administration in children with renal dysfunction.
    Leukemia, 1991, Volume: 5, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Female; Half-Life; Humans; Injections, Spinal; Kidney Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1991
Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.
    Cancer research, 1991, Feb-01, Volume: 51, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

1991
Hemiparesis and ischemic changes of the white matter after intrathecal therapy for children with acute lymphocytic leukemia.
    Cancer, 1991, Apr-15, Volume: 67, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Dysarthria; Female; Hemiplegia; Humans; Injections, Spinal; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

1991
Cranial nerve palsy in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
    Cancer, 1991, May-01, Volume: 67, Issue:9

    Topics: Child; Child, Preschool; Combined Modality Therapy; Cranial Nerve Diseases; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy Dosage; Sex Factors; Survival Analysis

1991
Effect of nitrous oxide and methotrexate on folate coenzyme pools of blast cells from leukemia patients.
    Leukemia research, 1991, Volume: 15, Issue:2-3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Methotrexate; Nitrous Oxide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Vitamin B 12

1991
[Abnormally high methotrexate levels in the cerebrospinal fluid after intravenous and intrathecal treatment for acute lymphoblastic leukemia].
    Archives francaises de pediatrie, 1991, Volume: 48, Issue:1

    Topics: Child; Child, Preschool; Humans; Infusions, Intravenous; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1991
[L-asparaginase-induced hyperlipidemia in a case of acute lymphoblastic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1991, Volume: 32, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Female; Humans; Hyperlipidemias; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

1991
[Serum monitoring of methotrexate (MTX) and 7-hydroxymethotrexate concentrations in patients treated with MTX using high-pressure liquid chromatography (HPLC) and comparison of serum MTX levels between HPLC method and fluorescence polarization immunoassay
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:7

    Topics: Adult; Aged; Child, Preschool; Chromatography, High Pressure Liquid; Female; Fluorescence Polarization Immunoassay; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1991
A longitudinal study of growth and growth hormone secretion in children during treatment for acute lymphoblastic leukemia.
    Medical and pediatric oncology, 1991, Volume: 19, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Body Height; Body Weight; Child; Child, Preschool; Combined Modality Therapy; Dexamethasone; Female; Glucocorticoids; Growth; Growth Hormone; Humans; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiotherapy Dosage; Vincristine

1991
[High-dose methotrexate and hyperphenylalaninemia].
    Archives francaises de pediatrie, 1991, Volume: 48, Issue:4

    Topics: Adolescent; Biopterins; Child; Child, Preschool; Humans; Hydroxylation; Lymphoma, Non-Hodgkin; Methotrexate; Phenylalanine; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1991
Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue.
    European journal of clinical pharmacology, 1990, Volume: 39, Issue:4

    Topics: Child; Child, Preschool; Chromatography, High Pressure Liquid; Half-Life; Humans; Leucovorin; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1990
Memory and learning sequelae in long-term survivors of acute lymphoblastic leukemia: association with attention deficits.
    The American journal of pediatric hematology/oncology, 1990,Summer, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Attention; Brain Diseases; Calcinosis; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Humans; Injections, Spinal; Learning Disabilities; Memory Disorders; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, High-Energy; Tomography, X-Ray Computed; Verbal Learning

1990
Methotrexate sensitivity in Down's syndrome: a hypothesis.
    Cancer chemotherapy and pharmacology, 1990, Volume: 25, Issue:5

    Topics: Down Syndrome; Drug Tolerance; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1990
[Preparation and cytotoxicity of McAb-HSA-MTX conjugates].
    Zhonghua yi xue za zhi, 1990, Volume: 70, Issue:10

    Topics: Albumins; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cytotoxicity Tests, Immunologic; Humans; Immunotoxins; Leukemia, Lymphoid; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

1990
Acute respiratory failure after intrathecal methotrexate administration.
    Pediatric hematology and oncology, 1990, Volume: 7, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infant; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Respiratory Insufficiency; Teniposide

1990
High dose cytosine arabinoside in the initial treatment of adults with acute lymphoblastic leukaemia.
    British journal of cancer, 1990, Volume: 62, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Humans; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine

1990
An animal model to study toxicity of central nervous system therapy for childhood acute lymphoblastic leukemia: effects on growth and craniofacial proportion.
    Cancer research, 1990, Oct-15, Volume: 50, Issue:20

    Topics: Animals; Cephalometry; Combined Modality Therapy; Female; Growth; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiotherapy; Rats; Rats, Inbred Strains; Skull

1990
An animal model to study toxicity of central nervous system therapy for childhood acute lymphoblastic leukemia: effects on behavior.
    Cancer research, 1990, Oct-15, Volume: 50, Issue:20

    Topics: Animals; Behavior, Animal; Brain; Cognition Disorders; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiotherapy; Rats; Rats, Inbred Strains; Sex Characteristics

1990
[Treatment of acute lymphoblastic leukemia in adults by the modified protocol of L-10M (Sloan-Kettering)].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1990, Volume: 31, Issue:6

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Vincristine

1990
[Effect of high-dose methotrexate on cerebral metabolic rate of glucose in rats and children with acute lymphoblastic leukemia].
    No to hattatsu = Brain and development, 1990, Volume: 22, Issue:5

    Topics: Adolescent; Age Factors; Animals; Brain; Child; Child, Preschool; Female; Glucose; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Rats, Inbred Strains

1990
Successful treatment of acute leukemia with t(4;11) in an infant with congenital hypothyroidism.
    The American journal of pediatric hematology/oncology, 1990,Fall, Volume: 12, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 4; Congenital Hypothyroidism; Cranial Irradiation; Cytarabine; Doxorubicin; Etoposide; Female; Humans; Hypothyroidism; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Translocation, Genetic; Vincristine

1990
[Transient dysfibrinogenemia and cerebral thrombosis following remission induction therapy for acute lymphoblastic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1990, Volume: 31, Issue:9

    Topics: Adult; Afibrinogenemia; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Female; Humans; Intracranial Embolism and Thrombosis; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine

1990
Multiagent chemotherapy in relapsed acute lymphoblastic leukemia in children.
    Cancer, 1990, Dec-15, Volume: 66, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Female; Humans; Hydrocortisone; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Teniposide; Vincristine

1990
7-Hydroxymethotrexate concentrations in serum and cerebrospinal fluid of children with acute lymphoblastic leukemia.
    Cancer chemotherapy and pharmacology, 1990, Volume: 27, Issue:2

    Topics: Aging; Antineoplastic Agents; Child; Child, Preschool; Folic Acid Antagonists; Humans; Infant; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

1990
[High methotrexate doses in the treatment program for acute lymphoblastic leukemia and lymphosarcoma in children].
    Voprosy onkologii, 1990, Volume: 36, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Evaluation; Drug Tolerance; Female; Humans; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Time Factors

1990
'MACHO' chemotherapy for stage IV B cell lymphoma and B cell acute lymphoblastic leukaemia of childhood. United Kingdom Children's Cancer Study Group (UKCCSG).
    British journal of haematology, 1990, Volume: 76, Issue:3

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Leucovorin; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Vincristine

1990
Maintenance chemotherapy for childhood acute lymphoblastic leukemia: should dosage be guided by white blood cell counts?
    The American journal of pediatric hematology/oncology, 1990,Winter, Volume: 12, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Risk Factors

1990
Cognitive functioning in long-term survivors of childhood leukemia: a prospective analysis.
    Journal of developmental and behavioral pediatrics : JDBP, 1990, Volume: 11, Issue:6

    Topics: Adolescent; Brain; Child; Combined Modality Therapy; Cranial Irradiation; Education, Special; Female; Follow-Up Studies; Humans; Injections, Spinal; Intelligence; Learning Disabilities; Longitudinal Studies; Male; Methotrexate; Neurocognitive Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiation Injuries; Radiotherapy Dosage; Substance-Related Disorders; Wechsler Scales

1990
Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group.
    Cancer research, 1990, Mar-15, Volume: 50, Issue:6

    Topics: Aminopterin; Animals; Biological Transport; Cell Division; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Humans; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Structure-Activity Relationship; Tumor Cells, Cultured

1990
Cryptosporidiosis and acute leukaemia.
    Archives of disease in childhood, 1990, Volume: 65, Issue:2

    Topics: Child; Child, Preschool; Cryptosporidiosis; Female; Humans; Immunosuppression Therapy; Infant; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spiramycin

1990
Biochemical evidence for synergistic combination treatment with methotrexate and 6-mercaptopurine in acute lymphoblastic leukemia.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Antineoplastic Combined Chemotherapy Protocols; DNA, Neoplasm; Drug Synergism; Humans; Lymphocytes; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thymidine; Tumor Cells, Cultured

1990
Pharmacokinetics of folinic acid in children with acute lymphoblastic leukemia.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1990
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Evaluation; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Spinal Cord Neoplasms; Testicular Neoplasms

1990
Sex differences in cognitive processing in children treated with CNS prophylaxis for acute lymphoblastic leukemia.
    Journal of pediatric psychology, 1990, Volume: 15, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Methotrexate; Neurocognitive Disorders; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Substance-Related Disorders

1990
Serum immunoreactive erythropoietin in children with acute leukaemia at various stages of disease--and the effects of treatment.
    European journal of haematology, 1990, Volume: 44, Issue:3

    Topics: Adolescent; Anemia; Child; Child, Preschool; Cytarabine; Dose-Response Relationship, Drug; Erythropoietin; Female; Hemoglobins; Humans; Infant; Leukemia, Myeloid, Acute; Longitudinal Studies; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1990
Comparative study on the pharmacokinetics of 7-hydroxy-methotrexate after administration of methotrexate in the dose range of 0.5-33.6 g/m2 to children with acute lymphoblastic leukemia.
    Medical and pediatric oncology, 1990, Volume: 18, Issue:3

    Topics: Adolescent; Age Factors; Child; Child, Preschool; Drug Administration Schedule; Female; Half-Life; Humans; Infant; Kinetics; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Sex Factors

1990
Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia.
    British journal of cancer, 1990, Volume: 61, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Liver Diseases; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Transaminases

1990
MTX clearance is more important for intermediate-risk ALL.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

1990
Pharmacokinetics of oral 6-mercaptopurine: relationship between plasma levels and urine excretion of parent drug.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Ascorbic Acid; Biological Availability; Child; Chromatography, High Pressure Liquid; Female; Glutathione; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

1990
Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children.
    The New England journal of medicine, 1990, Jul-05, Volume: 323, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Recurrence; Remission Induction; Risk Factors; Survival Analysis; Xanthine Oxidase

1990
Do visual evoked potentials detect neural damage in children treated for cancer?
    Developmental medicine and child neurology, 1990, Volume: 32, Issue:6

    Topics: Adolescent; Adult; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Evoked Potentials, Visual; Female; Follow-Up Studies; Humans; Male; Medulloblastoma; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiotherapy

1990
[Transverse leukonychia and anti-leukemia chemotherapy].
    Annales de pediatrie, 1990, Volume: 37, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child, Preschool; Cyclophosphamide; Cytarabine; Humans; Male; Methotrexate; Nail Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

1990
6-Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia.
    Cancer chemotherapy and pharmacology, 1990, Volume: 26, Issue:4

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Erythrocytes; Female; Guanine Nucleotides; Humans; Leukopenia; Male; Mercaptopurine; Methotrexate; Monitoring, Physiologic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides

1990
[Acral nevi following chemotherapy].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1990, Volume: 41, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Foot Diseases; Humans; Male; Mercaptopurine; Methotrexate; Nevus, Pigmented; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Neoplasms

1990
Contribution of mercaptopurine dose intensification to improved outcome in patients with lower-risk ALL.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

1990
CNS minimal disease therapy in childhood leukaemia: the place for irradiation.
    British journal of cancer, 1990, Volume: 62, Issue:1

    Topics: Brain Neoplasms; Child; Child, Preschool; Humans; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Spinal Cord Neoplasms

1990
Acute lymphoblastic leukemia; factors influencing relapse after allogeneic bone marrow transplantation.
    Bone marrow transplantation, 1990, Volume: 6 Suppl 1

    Topics: Adolescent; Bone Marrow Transplantation; Combined Modality Therapy; Female; Graft vs Host Disease; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

1990
Diurnal variation in the pharmacokinetics and myelotoxicity of mercaptopurine in children with acute lymphocytic leukemia.
    American journal of diseases of children (1960), 1990, Volume: 144, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Circadian Rhythm; Drug Administration Schedule; Female; Half-Life; Humans; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1990
In vitro methotrexate polyglutamate formation is elevated in acute lymphoid leukemia cells compared with acute myeloid leukemia and normal bone marrow cells.
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1988, Volume: 51, Issue:4

    Topics: Adult; Bone Marrow; Humans; In Vitro Techniques; Leukemia; Leukemia, Myeloid, Acute; Methotrexate; Peptides; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1988
Liquoral myelin basic protein in acute lymphoblastic leukemia.
    European journal of haematology, 1989, Volume: 42, Issue:4

    Topics: Adolescent; Adult; Female; Humans; Male; Methotrexate; Middle Aged; Myelin Basic Protein; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
Minimal neuropsychological sequelae following prophylactic treatment of the central nervous system in adult leukaemia and lymphoma.
    British journal of cancer, 1989, Volume: 60, Issue:5

    Topics: Adult; Aged; Brain; Brain Neoplasms; Combined Modality Therapy; Electroencephalography; Female; Humans; Intelligence Tests; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, High-Energy; Spinal Cord Neoplasms

1989
[Neurofibroma-associated left peroneal nerve palsy in a patient with acute lymphoblastic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1989, Volume: 30, Issue:6

    Topics: Child; Female; Humans; Lumbar Vertebrae; Methotrexate; Neoplasms, Multiple Primary; Neurofibroma; Paralysis; Peripheral Nervous System Diseases; Peroneal Nerve; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sacrum; Spinal Neoplasms; Vincristine

1989
Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:12

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Humans; Leukocyte Count; Mercaptopurine; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Analysis; Thioguanine

1989
Disposition of oral methotrexate in children with acute lymphoblastic leukemia and its relation to 6-mercaptopurine pharmacokinetics.
    Medical and pediatric oncology, 1989, Volume: 17, Issue:6

    Topics: Administration, Oral; Adolescent; Age Factors; Child; Child, Preschool; Female; Humans; Male; Mercaptopurine; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
Maintenance chemotherapy for childhood acute lymphoblastic leukemia: relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes.
    Cancer chemotherapy and pharmacology, 1989, Volume: 25, Issue:1

    Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Leukocyte Count; Liver; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Time Factors; Transaminases; Vincristine

1989
Intrathecal methotrexate toxicity.
    The Journal of the Association of Physicians of India, 1989, Volume: 37, Issue:5

    Topics: Adult; Female; Humans; Injections, Spinal; Methotrexate; Paraplegia; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
Low-dose methotrexate-induced changes in intestinal permeability determined by polyethylene glycol polymers.
    Journal of pediatric gastroenterology and nutrition, 1989, Volume: 9, Issue:3

    Topics: Adolescent; Animals; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
[Meningeal passage of folinic acid in treatment protocols using LAL with methotrexate in children].
    Bulletin du cancer, 1989, Volume: 76, Issue:8

    Topics: Child, Preschool; Humans; Injections, Jet; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
Sensitivity to purine analogues in childhood leukemia assessed by the automated MTT-assay.
    Advances in experimental medicine and biology, 1989, Volume: 253A

    Topics: Child; Coloring Agents; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thioguanine

1989
The basis for intrinsic drug resistance or sensitivity to methotrexate.
    Advances in enzyme regulation, 1989, Volume: 29

    Topics: Carcinoma, Squamous Cell; Drug Resistance; Head and Neck Neoplasms; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Soft Tissue Neoplasms; Tumor Cells, Cultured

1989
Skin rash after completion of therapy for leukemia in childhood.
    Pediatric hematology and oncology, 1989, Volume: 6, Issue:1

    Topics: Erythema; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
Reinduction therapy for advanced or refractory acute lymphoblastic leukemia of childhood.
    Cancer, 1989, Apr-15, Volume: 63, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Administration Schedule; Female; Humans; Infant; Male; Methotrexate; Mycoses; Platelet Count; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine

1989
Induction of partial synchronization of leukemia cells by continuous infusion of low-dose methotrexate followed by citrovorum factor.
    Journal of the National Cancer Institute, 1989, Oct-04, Volume: 81, Issue:19

    Topics: Bone Marrow; Child; Cytological Techniques; Humans; Infusions, Intravenous; Interphase; Leucovorin; Methotrexate; Myelodysplastic Syndromes; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
The significance of an isolated central nervous system relapse, occurring as first relapse in children with acute lymphoblastic leukemia.
    Cancer, 1989, May-15, Volume: 63, Issue:10

    Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Retrospective Studies; Time Factors

1989
Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance.
    Cancer research, 1989, May-01, Volume: 49, Issue:9

    Topics: Biological Transport; Carrier Proteins; Cell Division; Drug Resistance; Folate Receptors, GPI-Anchored; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Tumor Cells, Cultured

1989
Reversible treatment-related leukoencephalopathy.
    Journal of child neurology, 1989, Volume: 4, Issue:3

    Topics: Child; Child, Preschool; Cytarabine; Drug Synergism; Drug Therapy, Combination; Humans; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
Acute leukemia presenting as a unilateral exudative retinal detachment.
    Retina (Philadelphia, Pa.), 1989, Volume: 9, Issue:2

    Topics: Biopsy; Blood Cell Count; Bone Marrow Examination; Child; Cytarabine; Fluorescein Angiography; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retinal Detachment; Visual Acuity

1989
Cutaneous vasculitis after intermediate dose of methotrexate (IDMTX).
    British journal of haematology, 1989, Volume: 72, Issue:4

    Topics: Adult; Drug Hypersensitivity; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vasculitis, Leukocytoclastic, Cutaneous

1989
Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: a Pediatric Oncology Group study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Seizures

1989
Chronopharmacokinetics of oral methotrexate and 6-mercaptopurine: is there diurnal variation in the disposition of antileukemic therapy?
    The American journal of pediatric hematology/oncology, 1989,Fall, Volume: 11, Issue:3

    Topics: Administration, Oral; Child; Circadian Rhythm; Drug Administration Schedule; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
Evidence for CSF accumulation of 5-methyltetrahydrofolate during repeated courses of methotrexate plus folinic acid rescue.
    British journal of cancer, 1989, Volume: 59, Issue:4

    Topics: Child; Child, Preschool; Female; Humans; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolates

1989
Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1989, Oct-01, Volume: 141, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Boston; Child; Clinical Protocols; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Ontario; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Survival Rate; Vincristine

1989
Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.
    Cancer research, 1989, Nov-01, Volume: 49, Issue:21

    Topics: Adolescent; Adult; Burkitt Lymphoma; Child; Cysteine; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Methionine; Methotrexate; Models, Theoretical; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
Oral mucositis and salivary methotrexate concentration in intermediate-dose methotrexate therapy for children with acute lymphoblastic leukemia.
    Medical and pediatric oncology, 1989, Volume: 17, Issue:5

    Topics: Child; Child, Preschool; Female; Humans; Male; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Statistics as Topic; Time Factors

1989
Variability in the disposition of intraventricular methotrexate: a proposal for rational dosing.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1989, Volume: 7, Issue:11

    Topics: Adolescent; Burkitt Lymphoma; Child; Child, Preschool; Drug Implants; Humans; Injections, Intraventricular; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1989
[Isolated cerebral calcifications after prophylactic treatment of cerebromeningeal involvement of acute lymphoblastic leukemia: relation of psycho-intellectual sequelae].
    Pediatrie, 1989, Volume: 44, Issue:5

    Topics: Brain Diseases; Calcinosis; Child, Preschool; Female; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychotic Disorders; Radiotherapy; Tomography, X-Ray Computed

1989
The role of 5'nucleotidase in therapy-resistance of childhood leukemia.
    Medical hypotheses, 1988, Volume: 27, Issue:1

    Topics: 5'-Nucleotidase; Child, Preschool; Drug Resistance; Humans; Infant; Mercaptopurine; Methotrexate; Nucleotidases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleosides; Purine Nucleotides

1988
Behavioral side-effects of CNS prophylaxis.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1989, Volume: 28, Issue:2

    Topics: Adolescent; Brain; Humans; Intelligence; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography

1989
[Use of methotrexate in a child with trisomy 21. Value of blood levels].
    Annales de pediatrie, 1988, Volume: 35, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Down Syndrome; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1988
Cerebral glucose metabolic change after high-dose methotrexate treatment in patients with acute lymphocytic leukemia.
    Acta radiologica. Supplementum, 1986, Volume: 369

    Topics: Adolescent; Brain; Child; Child, Preschool; Female; Glucose; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, Emission-Computed

1986
[Intravenous immunoglobulin preparations in the adjuvant treatment of acute lymphoblastic leukemia in children].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1988, Aug-22, Volume: 43, Issue:34

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Humans; Immunization, Passive; Immunoglobulin G; Immunoglobulins, Intravenous; Infant; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Thioguanine; Vincristine

1988
Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia.
    Pediatric hematology and oncology, 1987, Volume: 4, Issue:1

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Body Height; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Female; Growth Disorders; Growth Hormone; Humans; Menarche; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Puberty; Vincristine

1987
High-dose methotrexate therapy (6-8 g/m2) in childhood malignancies: clinical tolerability and pharmacokinetics.
    Pediatric hematology and oncology, 1987, Volume: 4, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation; Half-Life; Humans; Infusions, Intravenous; Leucovorin; Lymphoma, Non-Hodgkin; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Stomatitis; Vincristine

1987
Convulsions and intracranial calcifications in a leukemic infant receiving only intrathecal methotrexate as central nervous system prophylaxis.
    Pediatric hematology and oncology, 1987, Volume: 4, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Diseases; Calcinosis; Cyclophosphamide; Doxorubicin; Humans; Infant; Injections, Spinal; Male; Meningeal Neoplasms; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Seizures; Vincristine

1987
Thyroid function in children after cytostatic treatment for acute leukemia.
    Pediatric hematology and oncology, 1988, Volume: 5, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thyroid Diseases

1988
Methotrexate concentration levels in the cerebrospinal fluid during high-dose methotrexate infusions: an unreliable prediction.
    Pediatric hematology and oncology, 1988, Volume: 5, Issue:2

    Topics: Adolescent; Blood-Brain Barrier; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1988
White cell count during maintenance chemotherapy for standard-risk childhood acute lymphoblastic leukemia: relation to relapse rate.
    Pediatric hematology and oncology, 1988, Volume: 5, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Leukocyte Count; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Remission Induction; Retrospective Studies; Risk Factors

1988
Prognosis after relapse in acute lymphoblastic leukemia in childhood.
    Pediatric hematology and oncology, 1986, Volume: 3, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cranial Irradiation; Doxorubicin; Humans; Life Tables; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Survival Rate; Sweden; Vincristine

1986
Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate after high-dose (33.6 g/m2) methotrexate therapy.
    Pediatric hematology and oncology, 1986, Volume: 3, Issue:2

    Topics: Child; Combined Modality Therapy; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Testicular Neoplasms

1986
Childhood non-Hodgkin's lymphoma and "leukemia-lymphoma syndrome": long-term results with the modified LSA2-L2 protocol.
    Pediatric hematology and oncology, 1986, Volume: 3, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Daunorubicin; Diagnosis, Differential; Evaluation Studies as Topic; Humans; Italy; Life Tables; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Rate; Syndrome; Vincristine

1986
Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia.
    Pediatric hematology and oncology, 1986, Volume: 3, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Contraindications; Drug Interactions; Drug Tolerance; Folic Acid; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis

1986
[Effects of the use of cranial radiotherapy. Findings obtained by computerized axial tomography and intellectual function tests].
    Anales espanoles de pediatria, 1988, Volume: 28, Issue:5

    Topics: Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Medulloblastoma; Mental Processes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed

1988
Leukoencephalopathy after prophylactic radiation for leukaemia in ataxia telangiectasia.
    Archives of disease in childhood, 1988, Volume: 63, Issue:9

    Topics: Ataxia Telangiectasia; Brain; Brain Diseases; Brain Neoplasms; Child, Preschool; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy

1988
Pulsatile growth hormone secretion in children with acute lymphoblastic leukemia after 1800 cGy cranial radiation.
    International journal of radiation oncology, biology, physics, 1988, Volume: 15, Issue:4

    Topics: Adolescent; Body Height; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Growth Hormone; Humans; Male; Meningeal Neoplasms; Methotrexate; Periodicity; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1988
Pharmacokinetics of subcutaneous methotrexate.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1988, Volume: 6, Issue:12

    Topics: Absorption; Administration, Oral; Adolescent; Adult; Animals; Child; Child, Preschool; Female; Humans; Injections, Subcutaneous; Macaca mulatta; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1988
[Combination of radio-chemotherapy for curing of childhood hematologic tumors: preventive approaches and problems on CNS involvement].
    Gan no rinsho. Japan journal of cancer clinics, 1988, Volume: 34, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Invasiveness; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis

1988
Neuropsychological effects of irradiation and chemotherapy treatments upon children with acute lymphoblastic leukemia: a case study of monozygotic twins.
    Neurotoxicology, 1988,Fall, Volume: 9, Issue:3

    Topics: Adolescent; Cognition; Combined Modality Therapy; Diseases in Twins; Female; Follow-Up Studies; Humans; Intelligence Tests; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Twins; Twins, Monozygotic

1988
[Long-term survival following acute lymphoblastic leukemia (ALL) in childhood].
    Archiv fur Geschwulstforschung, 1988, Volume: 58, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

1988
Aggressive treatment improves survival in adult acute lymphoblastic leukemia.
    European journal of haematology, 1988, Volume: 41, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blood Transfusion; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation; Humans; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Middle Aged; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine

1988
Short-term intensive treatment (V.A.A.P.) of adult acute lymphoblastic leukemia and lymphoblastic lymphoma.
    European journal of haematology, 1988, Volume: 41, Issue:5

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cytarabine; Doxorubicin; Drug Evaluation; Female; Humans; Lymphoma, Non-Hodgkin; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine

1988
[Meningeal involvement in ALL. Comparative study of 2 methods of protecting the CNS].
    Anales espanoles de pediatria, 1988, Volume: 29 Suppl 34

    Topics: Central Nervous System Diseases; Child, Preschool; Combined Modality Therapy; Female; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1988
Twelve years experience with methotrexate infusions in childhood ALL.
    Anales espanoles de pediatria, 1988, Volume: 29 Suppl 34

    Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Humans; Infant; Infusions, Intravenous; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1988
Treatment of high-risk acute lymphoblastic leukemia with protocols PETHEMA LAL 7/78 and LAL 17/84.
    Anales espanoles de pediatria, 1988, Volume: 29 Suppl 34

    Topics: Adolescent; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Clinical Protocols; Cytarabine; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine

1988
CNS relapse in children with acute lymphoblastic leukemia after cranial prophylaxis.
    Indian journal of cancer, 1988, Volume: 25, Issue:3

    Topics: Adolescent; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Spinal Cord Neoplasms

1988
[Serial spectral EEG analysis in children treated with intermediate-dose methotrexate (ID-MTX)].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1988, Volume: 29, Issue:11

    Topics: Brain; Child; Child, Preschool; Electroencephalography; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1988
[Interstitial nephritis developed during maintenance chemotherapy in a child with acute lymphocytic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1988, Volume: 29, Issue:11

    Topics: Child; Humans; Male; Methotrexate; Nephritis, Interstitial; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction

1988
[Epilepsy as a late sequela of therapy in acute lymphoblastic leukosis--case report].
    Medicinski pregled, 1988, Volume: 41, Issue:9-10

    Topics: Adolescent; Epilepsy; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors

1988
[Preliminary evaluation of the treatment of recurrences of acute lymphoblastic leukemia by the BFM (Henze) method].
    Pediatria polska, 1988, Volume: 63, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Thioguanine; Time Factors; Vincristine

1988
[Effect of prognostic factors on the course of acute lymphoblastic leukemia in children].
    Pediatria polska, 1988, Volume: 63, Issue:11

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infant; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Thioguanine; Time Factors; Vincristine

1988
[Pharmacokinetics of methotrexate in children with acute lymphoblastic leukemia].
    Boletin medico del Hospital Infantil de Mexico, 1988, Volume: 45, Issue:10

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Half-Life; Humans; Infant; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine

1988
[Monitoring of methotrexate treatment of children with proliferative diseases of the hematopoietic system].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1988, Aug-15, Volume: 43, Issue:33

    Topics: Adolescent; Child; Child, Preschool; Histiocytosis, Langerhans-Cell; Humans; Infusions, Intravenous; Injections, Intravenous; Lymphoma; Methotrexate; Monitoring, Physiologic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

1988
Plasma protein fractions and alpha 1-acidglycoprotein as tumor markers in acute lymphoblastic leukemia.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers, Tumor; Blood Proteins; Brain Neoplasms; Doxorubicin; Humans; Mercaptopurine; Methotrexate; Orosomucoid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine

1987