methotrexate has been researched along with Acute Lymphoid Leukemia in 1531 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 83 (5.42) | 18.7374 |
| 1990's | 468 (30.57) | 18.2507 |
| 2000's | 446 (29.13) | 29.6817 |
| 2010's | 400 (26.13) | 24.3611 |
| 2020's | 134 (8.75) | 2.80 |
| Authors | Studies |
|---|---|
| Devraj, R; Gangjee, A; Kisliuk, RL; McGuire, JJ | 1 |
| Araki, R; Fujiki, T; Ikawa, Y; Kuroda, R; Maeba, H; Mase, S; Nishimura, R; Noguchi, K; Wada, T; Yachie, A | 1 |
| Astorquizaga, L; Cheistwer, A; Font, D; Marin, F; Palmieri, F | 1 |
| Al-Salami, H; Goločorbin-Kon, S; Lazarević, S; Mikov, M; Mooranian, A; Rajšić, I; Vukmirović, S; Đanić, M | 1 |
| Duarte, FB; Lima, TT; Nóbrega, PR; Rodrigues, PGB | 1 |
| Blomgren, A; Hansson, K; Heldrup, J; Isaksson, A; Orrling, H; Pronk, CJ; Schliamser, G | 1 |
| Hasegawa, D; Hosoya, Y; Kuroko, Y; Manabe, A; Yoshihara, H | 1 |
| McNeer, JL; Schmiegelow, K | 1 |
| Hamada, S; Hokama, N; Hyakuna, N; Nakamura, K; Nakanishi, K; Shiohira, H | 1 |
| Aguilar Martínez, JC; Campos Gonzaga, L; García Martínez, A; Mateos Millán, D | 1 |
| Arunkumar, G; Kaur, H; Paul, SFD; Ramalingam, R; Scott, JX; Sneha, LM; Srinivasan, A | 1 |
| Advani, AS; Aldoss, I; Baer, MR; Bhave, RR; Erba, HP; Fang, M; Harvey, RC; Klisovic, RB; Litzow, MR; Moseley, A; O'Dwyer, KM; Othus, M; Park, JH; Sharon, E; Stock, W; Stone, RM; Wieduwilt, MJ; Willman, CL; Wood, BL | 1 |
| Akaihata, M; Hori, T; Miyata, K; Okumura, A; Shimomura, Y | 1 |
| Als-Nielsen, B; Anastasopoulou, S; Banerjee, J; Eriksson, MA; Harila-Saari, A; Helenius, M; Heyman, MM; Johannsdottir, IM; Jonsson, OG; MacGregor, S; Mateos, MK; Mayoh, C; Mikkel, S; Myrberg, IH; Nielsen, RL; Niinimäki, R; Ranta, S; Schmiegelow, K; Taskinen, M; Vaitkeviciene, G; Warnqvist, A; Wolthers, B | 1 |
| Kong, XY; Li, M; Wang, SM | 2 |
| Khera, S; Negi, V; Sharma, G; Shaw, SC | 1 |
| Fellah, S; Gandy, K; Hudson, MM; Jacola, LM; Krull, KR; Phillips, N; Pui, CH; Reddick, WE; Scoggins, MA; Sitaram, R; van der Plas, E | 1 |
| Kaczmarska, A; Lejman, M; Śliwa-Tytko, P; Zawitkowska, J | 1 |
| Chaudhry, QU; Ghafoor, T; Hussain, F; Mahmood, SK; Rehman, J | 1 |
| Lee, SHR; Schmiegelow, K; Toksvang, LN; Yang, JJ | 1 |
| Boufrikha, W; Boukhriss, S; Cheffaï, A; Laatiri, MA; Rakez, R | 1 |
| Jin, RM; Li, K; Shen, YQ; Wang, ZJ; Wu, XY; Xu, WF; Zhou, F | 1 |
| Faria, MJ; Fernanda, T; Rita, D; Rui, B | 1 |
| Bojalil-Álvarez, L; Cortés, JE; Fernández-Gutiérrez, JA; García-Villaseñor, E; Murrieta-Álvarez, I; Reyes-Cisneros, OA; Ruiz-Argüelles, GJ; Ruiz-Delgado, GJ; Sánchez-Bonilla, D | 1 |
| Boyunağa, Ö; Karamercan, S; Kaya, Z; Koçak, Ü; Topuz Türkcan, B; Uyar Göcün, P; Yazol, M | 1 |
| Borges, KS; Cruzeiro, GAV; Junior, HLR; Laranjeira, ABA; Moreno, DA; Ramalho, FS; Rego, EM; Salomão, KB; Scrideli, CA; Silva, CLA; Tone, LG; Yunes, JA | 1 |
| Ding, MM; Huang, ZZ; Jia, YP; Liu, J; Lu, AD; Qin, J; Wu, J; Zhang, LP; Zuo, YX | 1 |
| Alvarado, Y; Ferrajoli, A; Garcia-Manero, G; Garris, R; Huang, X; Jabbour, E; Jain, N; Kadia, TM; Kantarjian, H; Konopleva, M; Macaron, W; Patel, KP; Ravandi, F; Short, NJ; Thompson, PA; Yilmaz, M | 1 |
| Calvo, C; Delgado, EF; Ruggeri, RA | 1 |
| Fujisawa, H; Hao, A; Komaki, S; Matsumoto, H; Mitsui, Y; Narukawa, K; Shirasugi, Y; Takahashi, T | 1 |
| Dabaja, BS; Fang, PQ; Nasr, L; Short, NJ; Wu, SY | 1 |
| Antolinez, YV; Colunga-Pedraza, JE; Colunga-Pedraza, PR; Fierro-Saenz, S; González-Llano, O; Lopez-Reyna, IG; Montes-Tapia, FF | 1 |
| Cohen, IJ; Sadeh, M; Toledano, H | 1 |
| Bernhardt, MB; Brown, AL; Gramatges, MM; Harris, RD; Lupo, PJ; Rabin, KR; Schafer, ES; Scheurer, ME; Taylor, OA; Zobeck, MC | 1 |
| Al Sabahi, A; Albiroty, K | 1 |
| Chen, C; Li, X; Qi, J; Yongjing, W | 1 |
| Bernhardt, MB; Kamdar, KY; Lupo, PJ; Rabin, KR; Scheurer, ME; Zobeck, M | 1 |
| Chen, H; Deng, QM; Huang, S; Li, F; Liu, XX; Zhang, JM; Zhu, XX | 1 |
| Chen, YC; Hsiao, CC; Hsieh, HY; Huang, LT; Huang, YC; Lo, WS; Sheen, JM; Wang, SC | 1 |
| Fang, Q; Hao, Q; Huang, X; Mi, Y; Wang, J; Wang, Y; Wei, H; Zhang, P | 1 |
| Attarbaschi, A; Barbaric, D; Bodmer, N; Cario, G; Colombini, A; Conter, V; Dalla-Pozza, L; Elitzur, S; Heilmann, J; Izraeli, S; Mann, G; Möricke, A; Niggli, F; Rizzari, C; Schrappe, M; Silvestri, D; Stary, J; Valsecchi, MG; Vieth, S; Zapotocka, E; Zimmermann, M | 1 |
| Chan, A; Ciurea, SO; Doh, J; Griffin, SP; Jeyakumar, D; Kongtim, P; Lee, BJ; O'Brien, S | 1 |
| Li, L; Liu, WE; Ma, Y; Zhang, LF; Zhang, XC | 1 |
| Alvarado, Y; Dabaja, B; Garcia-Manero, G; Garris, R; Haddad, FG; Jabbour, E; Jacob, J; Jain, N; Jorgensen, J; Kadia, T; Kanagal-Shamanna, R; Kantarjian, H; Kebriaei, P; Khouri, I; Loghavi, S; O'Brien, S; Paul, S; Ravandi, F; Sasaki, K; Short, NJ; Yilmaz, M | 1 |
| Curra, M; Dalla Costa, T; de Araújo, BV; de Oliveira Henz, P; Gregianin, LJ; Martins, M; Pinhatti, AV | 1 |
| Howell, K; Romanick, M; Vasquez, MR | 1 |
| Chen, Y; Cheng, Y; Liu, M; Wang, M; Zhao, L; Zhao, M | 1 |
| Gebhard, A; Lilienthal, P; Metzler, M; Rauh, M; Sager, S; Schmiegelow, K; Toksvang, LN; Zierk, J | 1 |
| Ambrosino, N; Awoniyi, O; Bernhardt, MB; Board, SG; Castellino, SM; Chavana, A; DeGroote, NP; Joshi, V; Miller, TP; O'Brien, MM; Pommert, L; Poweleit, EA; Ramsey, LB; Schafer, ES; Taylor, ZL; Ugboh, N | 1 |
| Chen, S; Gong, J; Jia, Y; Jian, C; Jian, J; Li, Z; Wang, H; Wang, T; Wang, X; Wang, Z; Xiang, T; Zhang, Y; Zhou, Y | 1 |
| Cheng, Z; Wang, S; Xie, F; Yang, M; Yin, Q | 1 |
| Chen, X; Dai, Y; Li, X; Meng, M; Sun, H; Yang, Z; Zhou, S | 1 |
| Canevarolo, RR; Cury, NM; Yunes, JA | 1 |
| Watanabe, K | 1 |
| Benesch, M; Egger, M; Flaschberger, S; Gorkiewicz, G; Karastaneva, A; Kohlmaier, B; Lackner, H; Marterer, R; Seidel, M; Sperl, D; Strenger, V; Trobisch, A; Urban, C | 1 |
| Kok, NTM; Ligthart-Beukhof, AC; van de Wetering, MD | 1 |
| de Jonge, R; Fiocco, M; Heil, SG; Oosterom, N; Pieters, R; Smith, DEC; Tissing, WJE; van den Heuvel-Eibrink, MM; van Zelst, BD | 1 |
| Gaynon, PS | 1 |
| Bhojwani, D; Carroll, WL; E, S; Evans, WE; Goodings, C; Li, C; Seibel, NL; Xu, H; Yang, JJ; Yang, W; Zhang, H; Zhao, X | 1 |
| Chen, K; Li, H; Li, J; Wang, Y; Xu, Q | 1 |
| Alexandrov, LB; Brady, SW; Cai, J; Cheng, C; Ding, L; Dong, L; Downing, JR; Du, L; Easton, J; Edmonson, MN; Flasch, DA; Hagiwara, K; Li, B; Li, H; Li, Y; Lin, TN; Liu, Y; Ma, X; Mulder, HL; Myers, MA; Pui, CH; Raphael, BJ; Rusch, M; Shao, Y; Shen, S; Sioson, E; Sun, H; Sun, HY; Sun, L; Szlachta, K; Tang, J; Tian, L; Wang, N; Wang, T; Xu, K; Yang, F; Yang, JJ; Yang, L; Zhang, H; Zhang, J; Zhang, Y; Zhao, J; Zhou, BS; Zhou, X; Zhu, X | 1 |
| Climent, F; Ivan, I; Mercadal, S | 1 |
| Bah, M; Becerra, E; Berumen-Segura, L; Escobar-Cabrera, J; Garay, E; García-Alcocer, G; Hernández-Pérez, A; Mendoza-Santiago, A | 1 |
| Karppinen, S; Lohi, O; Vihola, M | 1 |
| Jabbour, EJ; Kadia, TM; Kantarjian, HM; Rausch, CR | 1 |
| Attarbaschi, A; Bader, P; Barisone, E; Basso, G; Biondi, A; Cario, G; Caterina Putti, M; Cazzaniga, G; Colombini, A; Conter, V; Flotho, C; Kuhlen, M; Lang, P; Lauten, M; Linderkamp, C; Lo Nigro, L; Locatelli, F; Mann, G; Möricke, A; Niggli, F; Panzer-Grümayer, R; Parasole, R; Peters, C; Rizzari, C; Schrappe, M; Suttorp, M; Valsecchi, MG; Zimmermann, M | 1 |
| Hogan, WJ; Litzow, M; Schram, S; Sierzchulski, AG; Truong, H | 1 |
| Ibrahim, HM; Jamari, H; James, RJ; Noorizhab, MNF; Razali, RH; Salleh, MZ; Teh, KH; Teh, LK | 1 |
| Bhojwani, D; Dabagh, S; David, H; Doan, A; Young, S | 1 |
| Ahmed, MU; Al-Mamun, MMA; Apu, MNH; Biswas, SK; Hasnat, A; Islam, MR; Islam, MS; Kabir, AL; Nahar, Z; Nahid, NA; Zahra, FT | 1 |
| Hidaka, Y; Kurata, T; Matsuoka, D; Morita, D; Morota, H; Nakazawa, Y; Natsume, T; Okura, E; Saito, S; Sakashita, K; Shigemura, T; Tanaka, M; Uchida, E; Watanabe, T | 1 |
| Fustino, NJ; Juhl, K; Leister, J | 1 |
| Cortez Neto, L; Leite, RA; Matas, CG; Matas, SLA; Odone Filho, V; Santos, NP; Vosgrau, JS | 1 |
| Campana, D; Cheng, C; Coustan-Smith, E; Lins, MM; Lucena-Silva, N; Pedrosa, A; Pedrosa, F; Pedrosa, M; Ramos, AML; Ribeiro, RC; Rivera, GK; Vinhas, E; Zhou, Y | 1 |
| Ma, Y; Yang, XY; Zhang, H; Zhang, WP; Zhang, YX | 1 |
| Alten, J; Behrens, YL; Bergmann, AK; Buchmann, S; Cario, G; Cazzaniga, G; Davenport, CF; Ebersold, J; Fazio, G; Göhring, G; Hagedorn, M; Hofmann, W; Lentes, J; Möricke, A; Schieck, M; Schlegelberger, B; Schrappe, M; Stanulla, M; Steinemann, D; Thomay, K | 1 |
| Abedi, M; Esmaeili, A; Rahgozar, S | 1 |
| Abboud, MR; Chahrour, M; El-Khoury, H; El-Solh, H; Ghanem, KM; Hamideh, D; Muwakkit, SA; Saab, R; Saifi, O; Tamim, H; Tarek, N | 1 |
| García-Hernández, MH; Godina-González, S; Medina-Rosales, MN | 1 |
| Dokmanovic, L; Gasic, V; Janic, D; Kotur, N; Krstovski, N; Lazic, J; Milosevic, G; Pavlovic, S; Ristivojevic, B; Stankovic, B; Zukic, B | 1 |
| Abrahamsson, J; Grell, K; Grosjean, M; Gupta, R; Hjalgrim, LL; Jiang, C; Jónsson, ÓG; Kanerva, J; Lund, B; Moriyama, T; Nersting, J; Nielsen, RL; Nielsen, SN; Overgaard, U; Pruunsild, K; Quist-Paulsen, P; Schmiegelow, K; Tulstrup, M; Vaitkeviciene, G; Wolthers, BO; Yang, JJ; Zhang, H | 1 |
| Burke, MJ; Egelund, TA; Katzenstein, HM; Liberio, N; Ng, JS; Pommert, L; Siver, MJ | 1 |
| Li, M; Sun, LL; Wang, SM; Wu, WS; Yan, D | 1 |
| Bafna, V; Bartakke, S; Pawar, A; Sajith, M | 2 |
| Clevers, H; de Jonge, R; Driehuis, E; Heil, SG; Jansen, G; Kolders, S; Lin, M; Muller, IB; Oosterom, N; Pieters, R; van den Heuvel-Eibrink, MM | 1 |
| Chae, H; Cho, B; Choi, SH; Chung, NG; Kim, M; Kim, SK; Kim, Y; Lee, JW | 1 |
| Kong, XY; Li, M; Sun, LL; Wang, SM; Yan, D | 1 |
| Ariffin, H; Lim, CH; Rajagopal, R; Ramli, N; Seow, P; Tan, LK | 1 |
| Assanasen, C; Gramatges, MM; Khalfe, Y; Lucari, B; Mullikin, D; Ranch, D; Schafer, ES; Scheurer, ME; Zobeck, MC | 1 |
| Berg, SL; Bernhardt, MB; Cheng, WS; Foster, JH; Mangum, R; Schafer, ES | 1 |
| Asano, T; Iguchi, A; Miyasho, T | 1 |
| Björgvinsdóttir, H; Bohnstedt, C; Degn, M; Grell, K; Hafsteinsdottir, S; Heyman, M; Hoogerbrugge, P; Schmiegelow, K; Taskinen, M; Zeller, B; Østergaard, A | 1 |
| Beaumont, AL; Suner, L | 1 |
| Díez-Martín, JL; Domingo-González, A; Landete, E; Monsalvo, S; Osorio, S | 1 |
| Bernar, B; Crazzolara, R; Griesmacher, A; Kapelari, K; Kropshofer, G; Müller, T; Scholl-Bürgi, S | 1 |
| Dhingra, H; Kalra, M; Mahajan, A | 1 |
| Curra, M; Evangelista, JMC; Ferreira, MBC; Gabriel, AF; Gregianin, L; Martins, MAT; Martins, MD; Roesler, R; Schmidt, TR; Valer, JB | 1 |
| Elloumi, M; Frikha, F; Frikha, R; Jemaa, MB; Kamoun, H; Keskes, L; Rebai, T; Turki, I | 1 |
| Brice, A; Chatelut, E; Faguer, S; Gallais, F; Lafont, T; Marsili, S; Oberic, L; Puisset, F; Tavitian, S | 1 |
| Choi, L; Ho, RH; Schulte, RR; Stein, CM; Utreja, N; Van Driest, SL | 1 |
| Gangopadhyay, D; Radhakrishnan, V | 1 |
| MacDonald, T; Price, V; Whiley, AC | 1 |
| Aladle, DA; El Marghany, AB; El Menshawy, N; Sarhan, MM | 1 |
| Christensen, M; De Pietri, S; Frandsen, TL; Grell, K; Müller, K; Rathe, M | 1 |
| Autry, RJ; Bonten, EJ; Cheng, C; Crews, KR; Diouf, B; Evans, WE; Lopez-Lopez, E; McCorkle, JR; Mullighan, CG; Panetta, JC; Paugh, SW; Pei, D; Pounds, S; Pui, CH; Relling, MV; Roberts, KG; Shi, L; Smart, B; Smith, C; Yang, W | 1 |
| Apak, H; Celkan, T; Koka, A; Özdemir, N; Sunamak, EÇ; Yantiri, L | 1 |
| Al-Sheikh, A; Alshamaseen, D; Farhad, R; Yousef, AM | 1 |
| Chen, RJ; Cui, X; He, J; Lian, LJ; Lin, B; Lin, XD; Sun, W; Wang, Z; Ye, WJ | 1 |
| Alsdorf, WH; Bokemeyer, C; Frenzel, C; Karagiannis, P; Langebrake, C | 1 |
| Banerjee, P; Cheung, YT; Glass, JO; Hudson, MM; Kesler, SR; Krull, KR; Liu, W; Ogg, RJ; Phillips, NS; Pui, CH; Reddick, WE; Robison, LL; Scoggins, MA; Srivastava, D | 1 |
| Candoni, A; Canichella, M; Cavalli, M; Chiaretti, S; Conter, V; D'Aloisio, M; De Propris, MS; Elia, L; Fazi, P; Foà, R; Guarini, A; Luppi, M; Martino, B; Messina, M; Moleti, ML; Piciocchi, A; Starza, ID; Testi, AM; Vignetti, M; Vitale, A | 1 |
| Chen, K; Wang, L; Xu, Q | 1 |
| Fujiwara, K; Ishida, H; Kanamitsu, K; Kanzaki, H; Kitamura, Y; Sendo, T; Shimada, A; Tatebe, Y; Tsukahara, H; Washio, K | 1 |
| Chen, MH; Chen, YY; Cheng, Y; Lin, BJ; Liu, MB; Qiu, HQ; Que, WC; Yang, L; Zhuang, Q | 1 |
| Abe, K; Aono, H; Fushimi, S; Kondo, R; Kume, M; Saito, M; Shibata, K; Takahashi, N; Takahashi, S; Teshima, K | 1 |
| Baran, J; Embry, L; Hardy, KK; Hullmann, SE; Jacola, LM; Kairalla, JA; Larsen, EC; Noll, RB; Willard, VW; Winick, N | 1 |
| Alvaro, F; Barbaric, D; Barbaro, PM; Catchpoole, D; Chenevix-Trench, G; Dalla-Pozza, L; George, C; Giles, JE; Kotecha, RS; Lawson, JA; MacGregor, S; Marshall, GM; Mateos, MK; Mayoh, C; Mechinaud, F; Quinn, MCJ; Revesz, T; Sutton, R; Trahair, TN | 1 |
| Phillips, B; Proudfoot, RH | 1 |
| Gaipov, A; Issakov, S; Jubaniyazov, B; Saparov, A; Sazonov, V; Tobylbayeva, Z | 1 |
| Audino, AN; Chung, C; Fernandez Faith, E; Guinipero, T; Ravi, M; Ridpath, A | 1 |
| Haque, AU; Jabbar, N; Mirza, S; Razi, W; Sadiq, H; Ullah, R | 1 |
| Hama, A; Matsumoto, K; Sakaguchi, H; Takeuchi, T; Yoshida, N | 1 |
| Chen, ZB; Ding, CC; Liu, S; Qu, Q; Wang, GQ; Wen, FQ; Zhan, M | 1 |
| Agrawal, S; Krawczyk, M; Makuch, S; Nowak, M; Pastuch-Gawołek, G; Szeja, W; Wiśniewski, J; Woźniak, M | 1 |
| Abrahamsson, J; Appell, ML; Grell, K; Hjalgrim, LL; Jónsson, ÓG; Kanerva, J; Lund, B; Nersting, J; Nielsen, SN; Pruunsild, K; Schmiegelow, K; Toksvang, LN; Vaitkeviciene, G | 1 |
| Billiet, T; D'Hooge, R; Deprez, S; Elens, I; Labarque, V; Lemiere, J; Sleurs, C; Uyttebroeck, A; Van Gool, S | 1 |
| Cho, HW; Choi, R; Chun, MR; Hyun, JK; Ju, HY; Kim, S; Koo, HH; Lee, JW; Lee, SY; Park, J; Won, H; Yi, ES | 1 |
| Elloumi, M; Frikha, R; Kamoun, H; Rebai, T | 1 |
| Athale, U; Bassal, M; Breakey, VR; Gibson, PJ; Gupta, S; Li, Q; Mittmann, N; Patel, S; Pechlivanoglou, P; Pole, JD; Silva, M; Sutradhar, R; Zabih, V | 1 |
| Abou Dalle, I; Bazarbachi, A; Bidikian, AH; El-Cheikh, J; Hourani, R | 1 |
| Abrahamsson, J; Andrés-Jensen, L; Frandsen, TL; Grell, K; Griškevičius, L; Harila-Saari, A; Joelsson, J; Jónsson, ÓG; Mogensen, SS; Nersting, J; Nielsen, SN; Niinimäki, R; Overgaard, UM; Quist-Paulsen, P; Rank, CU; Schmiegelow, K; Toft, N; Toksvang, LN; Vaitkevičienė, G | 1 |
| Aarnivala, H; Banerjee, J; Harila-Saari, A; Niinimäki, R; Pokka, T; Vepsäläinen, K | 1 |
| Caldito, EG; Elsebaie, M; Pescatore, JM | 1 |
| Bashari, MH; Idjradinata, P; Kaspers, GJL; Rakhmilla, LE; Raspati, H; Reniarti, L; Sari, NM; Supriyadi, E; Suryawan, N; Susanah, S; Zazuli, Z | 1 |
| Chen, F; Chen, J; Gong, Y; Li, X; Luo, L; Ma, Y; Shi, C; Sun, Y; Wang, L; Xu, Z | 1 |
| Bai, H; Liu, WH; Mao, DF; Ren, LW; Wang, ZH; Wu, T; Xue, F; Yu, LL | 1 |
| Algarra-Algarra, JL; Gómez-Catalán, I; Hernández-Fernández, F; Ibañez-García, Á; Marín-Sánchez, A; Martínez-Fernández, G; Montoya-Morcillo, MC; Romero-Macías, JR | 1 |
| Al Achkar, W; Aljapawe, A; As'sad, M; Liehr, T; Wafa, A | 1 |
| Huang, RS; Marable, M; Rudin, S | 1 |
| Albertsen, BK; De Pietri, S; Frandsen, TL; Grell, K; Lähteenmäki, PM; Nersting, J; Nielsen, SN; Nilsson, D; Nystad, TA; Rosthøj, S; Schmiegelow, K; Toksvang, LN; Wehner, PS | 1 |
| Al-Mahayri, ZN; Ali, BR; Patrinos, GP | 1 |
| Bekker-Mendez, C; Del Carmen Pinto-Escalante, D; Del Carmen Rodríguez-Zepeda, M; Flores-Lujano, J; Flores-Villegas, LV; Fragoso, JM; García-Escalante, MG; González-Montalvo, PM; Guerra-Castillo, FX; Gutiérrez-Juárez, EI; Hidalgo-Miranda, A; Jiménez-Hernández, E; Jiménez-Morales, S; Leal, YA; Mejía-Aranguré, JM; Núñez-Enríquez, JC; Núñez-Villegas, NN; Pantoja-Guillen, F; Peñaloza-Gonzalez, JG; Pérez-Saldivar, ML; Ramírez-Bello, J; Ramírez-Florencio, M; Ramos-Cervantes, MT; Torres-Escalante, JL | 1 |
| Chen, ZP; Cui, L; Gao, C; Li, WJ; Li, ZG; Liu, SG; Wang, JX; Wu, MY; Yue, ZX; Zhang, RD; Zhang, YY; Zhao, XX; Zheng, HY | 1 |
| Cario, G; Conter, V; Dagdan, E; Hinze, L; Junk, S; Kratz, CP; Möricke, A; Schrappe, M; Stanulla, M; Zimmermann, M | 1 |
| Bernhardt, MB | 1 |
| Chang, YH; Chao, YH; Chiou, YH; Hsu, MC; Peng, CT; Wu, HP; Wu, KH; Yu, MS | 1 |
| de Jonge, R; den Hoed, MAH; García-Orad, A; Gutierrez-Camino, A; Heil, SG; Lopez-Lopez, E; Martin-Guerrero, I; Oosterom, N; Pieters, R; Pluijm, SMF; Tissing, WJE; van den Heuvel-Eibrink, MM | 1 |
| Guo, HM; Li, F; Ma, JM; Meng, L; Yin, DD; Zhou, XL | 1 |
| de la Maya, MD; de Murillo, SG; Gervasini, G; Jiménez, M; Vagace, JM | 2 |
| Adams, G; Apperley, JF; Brannigan, E; Davies, F; Fernando, F; Innes, AJ; Marchesi, JR; Mullish, BH; Pavlů, J | 1 |
| Eckert, C; Izraeli, S | 1 |
| Forster, VJ; McDonnell, A; McKay, JA; Theobald, R | 1 |
| Mescher, C; Slungaard, A | 1 |
| Berger, A; Bernhardt, MB; Felix-Ukwu, F; Reichert, K; Schafer, ES | 1 |
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| Audemard, A; Bergot, E; Chantepie, S; de la Gastine, B; Gac, AC; Reman, O; Verger, H | 1 |
| Cachia, D; Chi, L; Cortes, JE; Daver, N; Kamiya-Matsuoka, C; Kantarjian, HM; Pinnix, CC; Woodman, K | 1 |
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| Frandsen, T; Nersting, J; Rosthøj, S; Schmiegelow, K; Vang, SI | 1 |
| Bhojwani, D; Bowman, WP; Campana, D; Cheng, C; Coustan-Smith, E; Downing, JR; Evans, WE; Gruber, TA; Inaba, H; Jeha, S; Leung, WH; Pei, D; Pui, CH; Relling, MV; Ribeiro, RC; Rubnitz, JE; Sandlund, JT | 1 |
| AbdElaal, AM; Elfaragy, MS; Elzamarany, EA; Hagag, AA; Hassan, SM | 1 |
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| Abrahamsson, J; Asberg, A; Birgens, H; Frandsen, T; Griškevičius, L; Hallböök, H; Helt, LR; Heyman, M; Jónsson, ÓG; Klausen, TW; Palk, K; Pruunsild, K; Quist-Paulsen, P; Schmiegelow, K; Toft, N; Vaitkeviciene, G; Vettenranta, K | 1 |
| Arellano-Galindo, J; Bekker-Méndez, VC; Dueñas-González, MT; García-Jiménez, X; Jaimes-Reyes, EZ; Jiménez-Hernández, E; Marín-Palomares, T; Martínez Villegas, O; Mejía-Aranguré, JM; Ortíz-Fernández, A; Ortíz-Torres, MG; Sánchez-Jara, B; Tiznado-García, HM | 1 |
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| Abla, O; Di Giuseppe, G; Gupta, S; Hitzler, J; Wilejto, M | 1 |
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| Huang, YK; Liu, M; Meng, Y; Xiong, JJ; Yao, Q; Zhang, J; Zhang, Y; Zhao, YL | 1 |
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| Burger, JA; Champlin, R; Cortes, JE; Estrov, Z; Faderl, S; Ferrajoli, A; Garcia-Manero, G; Garris, R; Huang, X; Jabbour, E; Kantarjian, HM; Kebriaei, P; McCue, DA; O'Brien, SM; Ravandi, F; Rytting, ME; Thomas, DM; Verstovsek, S; Wierda, WG | 1 |
| Basu, D; Dubashi, B; Kodidela, S; Pradhan, SC | 1 |
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| Burgett, SE; Fritch Lilla, SA; McGann, KA; Wechsler, DS | 1 |
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| Alz, H; Juergens, C; Kremeike, K; Reinhardt, D | 1 |
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| Assaraf, YG; Cloos, J; Jansen, G; Kaspers, GJ; Peters, GJ; Raz, S; Sonneveld, E; Stark, M; Wojtuszkiewicz, A | 1 |
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| Goulden, N; Hough, R; Mitchell, C; Moorman, A; Rowntree, C; Vora, A; Wade, R | 1 |
| Andreano, A; Biondi, A; Devidas, M; Escherich, G; Goulden, N; Horibe, K; Hunger, SP; Locatelli, F; Moericke, A; Pieters, R; Pui, CH; Schrappe, M; Silverman, LB; Taskinen, M; Valsecchi, MG; Vora, A | 1 |
| Carroll, WL; Devidas, M; Dupuis, LL; Hunger, SP; Kadan-Lottick, NS; Lu, X; Maloney, KW; Mattano, LA; Mitchell, HR; Sung, L; Winick, N | 1 |
| Cury, IJ; Kanda, PA; Kanda, RG; Mei, PA | 1 |
| Aricò, M; Attarbaschi, A; Barisone, E; Bartram, CR; Basso, G; Beier, R; Biondi, A; Caruso, R; Cazzaniga, G; Conter, V; Greiner, J; Harbott, J; Kremens, B; Kulozik, AE; Lo Nigro, L; Locatelli, F; Mann, G; Möricke, A; Niggli, F; Parasole, R; Ratei, R; Rössig, C; Schrappe, M; Silvestri, D; Stanulla, M; Valsecchi, MG; von Stackelberg, A; Zimmermann, M | 1 |
| Gao, J; Guo, J; Guo, X; Jia, CS; Li, Q; Zhou, CY; Zhu, YP | 1 |
| Assaraf, YG; Cloos, J; Escherich, G; Hoekstra, M; Jansen, G; Kaspers, GJ; Peters, GJ; Pieters, R; Sciarrillo, R; Sonneveld, E; Wojtuszkiewicz, A | 1 |
| Sauer, MG | 1 |
| Güntekin Ergun, S; Gürsel, T; Kaya, Z; Koçak, Ü; Perçin, F; Yazıcıoğlu, B; Yenicesu, İ | 1 |
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| Rosen, D; Sinno, MG; Wittler, R | 1 |
| Abdelaziz, DH; Attia, AS; El-Sayed, MH; Elhosseiny, NM; Khaleel, SA; Sabry, NA | 1 |
| Cortes, JE; Garcia-Manero, G; Garris, R; Issa, GC; Jabbour, E; Kantarjian, H; Luthra, R; O'Brien, SM; Patel, K; Ravandi, F; Sasaki, K; Short, NJ; Thomas, D | 1 |
| Das, B; Dolai, TK; Lath, C; Purkait, R | 1 |
| Brinkman, TM; Cheung, YT; Fellah, S; Hudson, MM; Kimberg, C; Krull, KR; Liu, W; Ogg, R; Pui, CH; Reddick, WE; Robison, LL; Srivastava, D | 1 |
| Akman, B; Bilgili, G; Gülen, H; Ovalı, GY; Özgüven, AA; Yıldırım, AT | 1 |
| Alamillo, I; Lopez, B; Medina-Sanson, A; Moreno-Galván, M; Moreno-Guerrero, S; Ramírez-Pacheco, A | 1 |
| Frandsen, TL; Grell, K; Hjalgrim, LL; Nersting, J; Nielsen, SN; Schmiegelow, K | 1 |
| Astigarraga, I; Garcia de Andoin, N; Garcia-Orad, A; Gutierrez-Camino, A; Iparraguirre, L; Martin-Guerrero, I; Navajas, A; Sastre, A; Umerez, M | 1 |
| Abate, F; Ambesi-Impiombato, A; Balbin, M; Basso, G; Carpenter, Z; da Silva-Almeida, AC; Devidas, M; Eckert, C; Ferrando, AA; Gastier-Foster, JM; Kato, M; Khiabanian, H; Kirschner-Schwabe, R; Koh, K; Loh, ML; Nicolas, C; Oshima, K; Paganin, M; Palomero, T; Penson, A; Perez-Garcia, A; Rabadan, R; Sanchez-Martin, M; Sulis, ML; Tzoneva, G | 1 |
| Bhojwani, D; Brinkman, TM; Cheung, YT; Glass, JO; Hudson, MM; Hwang, SN; Krull, KR; Liu, W; Pui, CH; Reddick, WE; Robison, LL; Sabin, ND; Srivastava, D | 1 |
| Abdelaziz, DH; Al-Ghobashy, MA; Attia, AS; El-Sayed, MH; Elhosseiny, NM; Hassan, SA; Sabry, NA | 1 |
| Attarbaschi, A; Dworzak, M; Haas, OA; König, M; Mann, G; Meister, B; Pichler, H; Pötschger, U; Reismüller, B; Schmitt, K; Steiner, M; Urban, C | 1 |
| Bernhardt, MB; Foster, JH; Schafer, ES; Smith, EO; Thompson, PA | 1 |
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| Blonquist, TM; Cole, PD; Finkelstein, Y; Neuberg, DS; Sallan, SE; Silverman, LB; Stevenson, KE; Vijayanathan, V; Vrooman, LM | 1 |
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| Huang, Z; Li, Y; Qian, JC; Ruan, JC; Tong, HF; Wang, JX; Wang, Z | 1 |
| Huang, JG; Suhaila, MI; Tambyah, PA; Yeoh, AE | 1 |
| Ebbesen, MS; Harila-Saari, A; Kristinsson, J; Nersting, J; Nygaard, U; Rosthøj, S; Schmiegelow, K; Sørensen, D; Vettenranta, K; Wesenberg, F | 1 |
| Derwich, K; Karmelita-Katulska, K; Pawlak, MA; Pilarczyk, J; Wachowiak, J; Zając-Spychała, O | 1 |
| Dujua, AC; Hernandez, FG | 1 |
| Kent, MW; McNamara, JM; McNerney, KO; Vasquez, JC | 1 |
| Drachtman, RA; Haines, C; Pan, WJ; Rogers, P | 1 |
| Ashford, JM; Cheng, C; Conklin, HM; Glass, JO; Jeha, S; Laningham, FH; Nassar, SL; Pui, CH; Reddick, WE; Zhou, Y | 1 |
| Campana, D; Pui, CH | 1 |
| Chao, YH; Tsao, TF | 1 |
| Brown, VI; Carroll, M; Chang, YJ; Fish, J; Grupp, SA; Hall, J; Norris, R; Reid, GS; Ryan, T; Seif, AE; Sheen, C; Teachey, DT | 1 |
| de la Fuente-Fernández, R; Martín-Vigo, AI; Pardo, J; Rabuñal-Martínez, MJ; Santos-García, D; Vázquez, F | 1 |
| Chen, JP; Lin, DX; Liu, JX; Tan, W | 1 |
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| Basso, G; Biondi, A; Fabbri, G; Locatelli, F; Paganin, M; Polato, K; Rizzari, C; Zecca, M | 1 |
| Ahmed, MA; Al-Tonbary, YA; El-Chennawi, FA; Mossad, YM | 1 |
| Abe, A; Hayasaka, K; Kawakami, K; Kawano, Y; Kumamoto, T; Nishikawa, T; Okamoto, Y; Tonooka, S | 1 |
| Al-Ahmari, A; Al-Yamani, A; Dupuis, L; Hitzler, J; Shah, N; Stephens, D | 1 |
| Brugnoletti, F; Inaba, H; Jeha, S; Laningham, FH; Morris, EB; Patay, Z; Pauley, JL; Pui, CH | 1 |
| Arai, T; Imataki, O; Ishida, T; Kitanaka, A; Kubota, Y; Ohnishi, H; Tanaka, T; Yamaoka, G | 1 |
| Diamantidis, MD; Girtovitis, F; Hatzitolios, A; Kaiafa, G; Kontoninas, Z; Ntaios, G; Papadopoulos, A; Saouli, Z; Savopoulos, C | 1 |
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| Guan, ZZ; Huang, HQ; Lin, H; Ling, JY; Liu, DG; Luo, WB; Sun, XF; Xia, Y; Xia, ZJ; Xiang, XJ; Zhen, L; Zhen, ZJ | 1 |
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| Becker, A; Bode, U; Jaehde, U; Schüsseler, P; Vezmar, S | 1 |
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| Goyal, RK | 1 |
| Cheng, C; Downing, JR; Evans, WE; French, D; Mullighan, CG; Pui, CH; Raimondi, SC; Relling, MV; Yang, W | 1 |
| Beckwith, KA; Cole, PD; Kamen, BA; Roychowdhury, S; Smith, AK; Vijayanathan, V | 1 |
| Seibel, NL | 1 |
| Hua, Y; Lu, W; Lu, XT; Yang, LH; Zhao, WH | 1 |
| Duan, J; He, W; Huang, YK; Li, HL; Liu, H; Lu, P; Yang, W; Zhang, Y | 1 |
| Aukema, EJ; Caan, MW; Grootenhuis, MA; Last, BF; Majoie, CB; Oudhuis, N; Reneman, L; Schouten-van Meeteren, AY; Vos, FM | 1 |
| Celik, M; Forta, H; Kandraloğlu, N; Kenangil, G; Necioğlu Orken, D; Yldrmak, Y | 1 |
| Björgvinsdóttir, H; Bohnstedt, C; Hafsteinsdottir, S; Schmiegelow, K; Taskinen, M; Zeller, B | 1 |
| Assaraf, YG; Avivi, I; Stark, M; Wichman, C | 1 |
| Campbell, M; De Lorenzo, P; Hann, I; Hovi, L; Janka-Schaub, G; Li, CK; Lönnerholm, G; Mann, G; Pieters, R; Schrappe, M; Stary, J; Valsecchi, MG | 1 |
| Chen, XJ; Liu, TF; Zhang, L | 1 |
| Borowitz, MJ; Bowman, WP; Camitta, BM; Campana, D; Cao, X; Carroll, WL; Cheng, C; Davies, SM; Devidas, M; Downing, JR; Evans, WE; Fan, Y; French, D; Hunger, SP; Neale, G; Pei, D; Pounds, SB; Pui, CH; Relling, MV; Treviño, LR; Willman, CL; Yang, JJ; Yang, W | 1 |
| Eden, T; Hill, F; Hussain, A; Mitchell, C; Richards, S; Simpson, J; Taylor, GM; Wade, R | 1 |
| Bagatini, MD; Battisti, V; Correa, MC; do Carmo Araújo, M; Maders, LD; Morsch, VM; Santos, KF; Schetinger, MR; Spanevello, RM | 1 |
| Behm, FG; Campana, D; Hijiya, N; Hudson, MM; Onciu, M; Pui, CH; Razzouk, BI; Ribeiro, RC; Sandlund, JT; Zhou, Y | 1 |
| Al-Modhwahi, I; Andersen, MK; Behrendtz, M; Forestier, E; Hasle, H; Heyman, M; Kristinsson, J; Nersting, J; Nygaard, R; Schmiegelow, K; Svendsen, AL; Vettenranta, K; Weinshilboum, R | 1 |
| Cheok, MH; Evans, WE; Kager, L | 1 |
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| Faderl, S; Garg, R; Kantarjian, H; Lovshe, D; O'Brien, S; Pierce, S; Ravandi, F; Thomas, D | 1 |
| Hall, CP; Harutyunyan, N; Kang, MH; Lock, RB; Papa, RA | 1 |
| Adamkiewicz-Drozynska, E; Balcerska, A; Bien, E; Dubaniewicz-Wybieralska, M; Krawczyk, M; Stachowicz-Stencel, T; Synakiewicz, A; Szalewska, M; Zielinski, P | 1 |
| Endo, K; Hamamoto, K; Higuchi, T; Kanazawa, T; Oriuchi, N | 1 |
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| Ansari, M; Gagné, V; Krajinovic, M; Labuda, M; Laverdière, C; Moghrabi, A; Sauty, G; Sinnett, D | 1 |
| de Boer, NK; van Asseldonk, DP; van Bodegraven, AA | 1 |
| Bayles, A; Bowman, WP; Boyett, JM; Campana, D; Cheng, C; Coustan-Smith, E; Downing, JR; Evans, WE; Handgretinger, R; Howard, SC; Jeha, S; Kaste, SC; Kun, LE; Leung, W; Metzger, ML; Onciu, M; Pei, D; Pui, CH; Raimondi, SC; Relling, MV; Ribeiro, RC; Rubnitz, JE; Sandlund, JT; Simmons, V | 1 |
| Ehninger, G; Gökbuget, N; Hamann, S; Hoff, H; Ramadanova, K; Reuner, U; Schaich, M | 1 |
| Bargetzi, M; Dudler, C; Gratwohl, A; Passweg, JR; Tichelli, A; Wernli, M | 1 |
| Bartoli, F; Decorti, G; Marino, S; Rabusin, M; Stocco, G; Tamaro, P; Verzegnassi, F | 1 |
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| Glass, JO; Johnson, DP; Laningham, FH; Pui, CH; Reddick, WE | 1 |
| Ambrosio, C; Caruso, A; Catozzi, L; De Mattei, M; Della Porta, MG; Di Raimondo, F; Gemmati, D; Masieri, FF; Ongaro, A; Pellati, A; Rigolin, G | 1 |
| Kamen, BA | 3 |
| Heyman, M; Kristinsson, J; Mogensen, UB; Rosthøj, S; Saarinen-Pihkala, U; Schmiegelow, K; Vettenranta, K; Wesenberg, F | 1 |
| Johnson, MD; Moots, PL; Weil, RJ; Zhuang, Z | 1 |
| Carroll, WL; Devidas, M; Downing, J; Evans, WE; French, D; Hunger, SP; Neale, G; Pui, CH; Raimondi, SC; Relling, MV; Treviño, LR; Willman, C; Yang, W | 1 |
| Hawks, RG; Meza, JL; Post-White, JE; Sacks, N; Seibel, NL; Smith, LM; Withycombe, JS | 1 |
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| Chapa-Rodríguez, A; Gómez-Almaguer, D; Gonzàlez-Llano, O; Jaime-Pérez, JC; Sandoval-González, A | 1 |
| Al-Shakfa, F; Ansari, M; Beaulieu, P; Brukner, I; Dulucq, S; Krajinovic, M; Kutok, JL; Laverdière, C; Milacic, I; Moghrabi, A; Neuberg, D; Sallan, SE; Silverman, LB; Sinnett, D | 1 |
| Bostrom, B; Breiger, D; Brouwers, P; Chen, L; Dziura, J; Kadan-Lottick, NS; Kaleita, T; Neglia, JP; Nicoletti, M; Northrup, V; Stork, L | 1 |
| Chan, D; Cheng, C; Evans, WE; Giacomini, KM; Panetta, JC; Pei, D; Pui, CH; Relling, MV; Shimasaki, N; Sparreboom, A; Treviño, LR; Yang, W | 1 |
| Abdulghaffar, EE; Abou El Asrar, M; Adly, AA; El-Bostany, EA; El-Ghouroury, EA; Tantawy, AA | 1 |
| Anderson, AW; Campbell, LK; Cannistraci, CJ; Compas, BE; Livesay, KL; Robinson, KE; Scaduto, M; Whitlock, JA | 1 |
| Dalhoff, K; Hedeland, RL; Hvidt, K; Lausen, B; Nersting, J; Rosthøj, S; Schmiegelow, K | 1 |
| Bertino, JR | 1 |
| Duan, MH; Han, B; Jiao, L; Li, J; Shen, T; Wang, Q; Wang, SJ; Xu, Y; Ye, M; Zhang, W; Zhao, YQ; Zhou, DB | 1 |
| Adam de Beaumais, T; Azougagh, S; Dervieux, T; Fakhoury, M; Jacqz-Aigrain, E; Medard, Y; Yakouben, K; Zhang, D | 1 |
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| Hockenberry, M; Jain, N; Kaemingk, K; Krull, KR; Miketova, P; Moore, IM; Stenzel, SL | 1 |
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| Dolzan, V; Faganel Kotnik, B; Grabnar, I; Jazbec, J | 1 |
| Alarcón-Romero, Ldel C; Gómez-Gómez, Y; Illades-Aguiar, B; Leyva-Vázquez, MA; Organista-Nava, J; Rivera-Ramírez, AB; Saavedra-Herrera, MV; Terán-Porcayo, MA | 1 |
| Aguiar, SS; Brandalise, SR; Brunetto, AL; Carvalho, EG; Cristofani, LM; Dobbin, JA; Lee, ML; Lopes, LF; Matsuda, EI; Melnikoff, KN; Morais, VL; Otubo, R; Pereira, WV; Pinheiro, VR; Pombo-de-Oliveira, MS; Scrideli, CA; Souza, MS; Tone, LG; Viana, MB; Yunes, JA | 1 |
| DeVore, KJ | 1 |
| Carlsen, N; Christensen, IJ; Dalhoff, K; Gregers, J; Lausen, B; Peterson, C; Rosthoej, S; Schmiegelow, K; Schroeder, H | 1 |
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| DeAngelo, DJ; Stone, RM | 1 |
| Altomare, M; Crescenzio, N; De Mattia, D; Del Vecchio, GC; Falanga, A; Giordano, P; Marchetti, M; Molinari, AC; Perutelli, P; Russo, G; Santoro, N; Saracco, P | 1 |
| Arya, LS; Bakshi, A; Gupta, VB; Kaur, S; Kulkarni, KP | 1 |
| Meeker, ND; Schiffman, JD; Yang, JJ | 1 |
| Ito, E; Kamio, T; Kudo, K; Sasaki, S; Takahashi, Y; Terui, K | 1 |
| Buffardi, S; Cianciulli, E; Mangione, A; Marchese, L; Menna, G; Misuraca, A; Nastro, A; Parasole, R; Petruzziello, F; Poggi, V | 1 |
| Barredo, JC; Devidas, M; Hunger, S; Leclerc, GJ; Sanderson, C | 1 |
| Fukaya, T; Isome, K; Iwata, A; Matsubara, K; Nigami, H; Taki, T; Taniwaki, M; Wada, T; Yura, K | 1 |
| Cortes, J; Faderl, S; Jabbour, E; Kantarjian, H; O'Brien, S; Pierce, S; Ravandi, F; Thomas, D | 1 |
| Fujita, K; Hidaka, Y; Hotta, N; Inada, H; Itonaga, N; Kawakami, K; Kawano, Y; Matsuzaki, A; Moritake, H; Nagatoshi, Y; Nakayama, H; Okamura, J; Suminoe, A; Ueda, K; Yamanaka, T; Yanai, F | 1 |
| Bansal, D; Kulkarni, KP; Marwaha, RK; Trehan, A | 1 |
| Diakos, C; Kager, L | 1 |
| Kesler, SR; Koovakkattu, D; Tanaka, H | 1 |
| Chuang, AY; Fang, L; Huang, CJ; Liu, CC; Tan, TD | 1 |
| Caceres-Marzal, C; Casado, MS; de Murillo, SG; Gervasini, G; Jimenez, M; Vagace, JM | 1 |
| Bastian, L; Einsiedel, HG; Henze, G; Seeger, K; Shalapour, S | 1 |
| Ancliff, P; Darbyshire, P; Goulden, N; Green, N; Hancock, J; Leighton, C; Love, S; Masurekar, A; Moorman, AV; Morgan, M; Parker, C; Révész, T; Saha, V; Sutton, R; Waters, R | 1 |
| Gill, D; Kennedy, G; Marlton, P; Mollee, P; Morris, K; Weston, H | 1 |
| Evans, WE; Panetta, JC; Pui, CH; Relling, MV; Sparreboom, A | 1 |
| Agarwal, A; Ouyang, T; Thamburaj, K; Vijay, K | 1 |
| Ding, Z; Liu, L; Wang, Z; Xu, W | 1 |
| Fukushima, T; Hanada, R; Hasegawa, D; Ishida, Y; Kikuchi, A; Kiyokawa, N; Koh, K; Manabe, A; Ohara, A; Saito, T; Tsuchida, M | 1 |
| Barredo, JC; Kuznetsov, JN; Leclerc, GJ; Leclerc, GM | 1 |
| Astwood, E; Vora, A | 1 |
| Akers, SM; Fortney, JE; Gibson, LF; Rellick, SL | 1 |
| Dabbagh, O; El-Bitar, MK; Muwakkit, SA | 1 |
| Balcerska, A; Balwierz, W; Chybicka, A; Derwich, K; Dobaczewski, G; Kowalczyk, JR; Kwiecińska, K; Matysiak, M; Moryl-Bujakowska, A; Pawelec, K; Płoszyńska, A; Sońta-Jakimczyk, D; Styczyński, J; Szczepański, T; Tomaszewska, R; Wachowiak, J; Wiśniewska-Slusarz, H; Wysocki, M | 1 |
| Balwierz, W; Cwiklińska, M; Stanuch, H | 1 |
| Blach, L; Borowitz, MJ; Bowman, WP; Camitta, BM; Carroll, AJ; Carroll, WL; Devidas, M; Hunger, SP; Larsen, EL; Linda, SB; Pullen, DJ; Shuster, J; Willman, CL; Winick, N | 1 |
| Greenberg, M; Grupp, S; Kennedy, DA; Koren, G | 1 |
| Bozonnat, MC; Bressolle, F; Daurès, JP; Hillaire-Buys, D; Margueritte, G; Martelli, N; Mathieu, O; Peyrière, H | 1 |
| Alsina, M; Anasetti, C; Ayala, E; Di Nicola, M; Fernandez, H; Field, T; Janssen, W; Kharfan-Dabaja, MA; Ochoa, L; Perez, L; Perkins, J; Pidala, J; Raychaudhuri, J; Santarone, S | 1 |
| Ballesteros, J; Garcia-Miguel, P; Garcia-Orad, A; Lopez-Lopez, E; Martin-Guerrero, I; Navajas, A; Piñan, MA | 1 |
| Baricordi, OR; Bellesi, S; Chiusolo, P; De Ritis, D; Giammarco, S; Leone, G; Marietti, S; Metafuni, E; Piccirillo, N; Rizzo, R; Sica, S; Stignani, M | 1 |
| Heldrup, J; Höglund, P; Jönsson, P; Schrøder, H; Skärby, T | 1 |
| Chukoskie, L; Kamen, BA | 1 |
| Cissoko, LN; Dembélé, AK; Diallo, DA; Diallo, YL; Ly, M; Touré, BA | 1 |
| Naik, S | 1 |
| Bowman, WP; Boyett, JM; Cheng, C; Evans, WE; Mikkelsen, TS; Panetta, JC; Pui, CH; Raimondi, SC; Relling, MV; Sandlund, JT; Sparreboom, A; Zhou, Y | 1 |
| Asselin, BL; Borowitz, MJ; Camitta, BM; Devidas, M; Hutchison, R; Lipshultz, SE; Pullen, J; Wang, C | 1 |
| Bohanec Grabar, P; Dolžan, V; Faganel Kotnik, B; Grabnar, I; Jazbec, J | 1 |
| Hattori, N; Nishioka, K; Sasaki-Ikesawa, K; Shimura, H; Tanaka, R; Tanaka, S | 1 |
| Cui, L; Gao, C; Li, WJ; Li, ZG; Liu, SG; Zhao, XX | 1 |
| Chen, YL; Cheng, HL; Chiou, SS; Liao, YM; Wu, SM | 1 |
| Angiolillo, A; Bostrom, BC; Buckley, PJ; Carroll, WL; Cole, C; Devidas, M; Gastier-Foster, JM; Gaynon, PS; Heerema, NA; Hunger, SP; La, M; Matloub, Y; Nachman, JB; Reaman, G; Sailer, S; Sather, H; Stork, LC; Thomson, B; Winick, N | 1 |
| Affinita, MC; Casale, F; Crisci, S; D'Angelo, V; Francese, M; Fusco, C; Iannotta, A; Indolfi, C; Indolfi, P; Napolitano, A; Oreste, M; Pecoraro, G; Ramaglia, M | 1 |
| Bouafia, F; Franchon, E; Gouraud, A; Pham, BN; Ranchon, F; Rioufol, C; Salles, G; Schwiertz, V; Vantard, N; Vial, T; You, B | 1 |
| Ansari, M; Gagné, V; Krajinovic, M; Labuda, M; Laverdière, C; Moghrabi, A; Rousseau, J; Sauty, G; Sinnett, D | 1 |
| Ebeid, EN; Eid, MA; El-Haggar, SM; El-Khodary, NM | 1 |
| Azuma, H; Hara, J; Isoyama, K; Ito, E; Kai, S; Kato, K; Kato, S; Kikuchi, A; Kobayashi, R; Nagamura-Inoue, T; Nagatoshi, Y; Oki, K; Takanashi, M; Yoshimi, A | 1 |
| de Jonge, R; den Boer, E; Lindemans, J; Luider, TM; Mathot, RA; Meesters, RJ; van Klaveren, RJ | 1 |
| Cakmakci, H; Gozmen, S; Hiz, S; Irken, G; Karapinar, TH; Oren, H; Tufekci, O; Yilmaz, S | 1 |
| Benesch, M; Lackner, H; Pansy, J; Urban, C | 1 |
| Altés, A; Badell, I; Baiget, M; del Río, E; Estella, J; Molina, J; Navajas, A; Rives, S; Salazar, J; Tasso, M; Torrent, M; Villa, M; Vivanco, JL | 1 |
| Green, DM; Huang, TT; Hudson, MM; Krull, KR; Morris, EB; Ness, KK; Pui, CH; Robison, LL | 1 |
| Bertino, JR; Bleyer, WA; Holcenberg, JS; Kamen, BA | 1 |
| Ballesteros, J; Garcia-Orad, A; Lopez-Lopez, E | 1 |
| Antonelli, A; Attinà, G; Barone, G; Chiaretti, A; Coccia, P; Iuvone, L; Maurizi, P; Pierri, F; Riccardi, R; Ruggiero, A | 1 |
| Adly, AA; Darwish, YW; El Aziz, AA; Hassanein, SM; Saeed, OM; Tantawy, AA | 1 |
| Abrahamsson, J; Andersen, EW; Behrentz, M; Castor, A; Frandsen, TL; Frost, BM; Heyman, M; Lausen, B; Schmiegelow, K; Vettenranta, K; Wehner, PS | 1 |
| Andersen, EW; Bohnstedt, C; Harila-Saari, A; Jonsson, OG; Kanerva, J; Levinsen, M; Lindblom, A; Lund, B; Schmiegelow, K; Shabaneh, D | 1 |
| Chi, ZF; Hao, LC; Li, S; Wang, H; Wang, XL | 1 |
| Balwierz, W; Bik-Multanowski, M; Galicka-Latala, D; Gozdzik, J; Pietrzyk, JJ; Strojny, W; Surmiak, M; Szymon, S | 1 |
| Greve, JM; Gualano, B; Muratt, MD; Perondi, MB; Pinto, AL; Roschel, H | 1 |
| Klapkova, E; Kotaska, K; Kukacka, J; Prusa, R; Suchanska, I; Urinovska, R | 1 |
| Biriukova, LS; Bogdanov, RF; Donskova, IA; Parovichnikova, EN; Pimenova, MA; Savchenko, VG; Shaforostova, II; Sokolov, AN; Ustinova, EN | 1 |
| Alvarez, A; Alvarez, CJ; Morales-Rojas, T; Morón-Medina, A; Viera, N | 1 |
| Csóka, M; Csordás, K; Eipel, O; Hegyi, M; Kovács, G; Pap, E | 1 |
| Buck, G; Gibson, B; Halsey, C; Hill, F; Richards, S; Vargha-Khadem, F | 1 |
| Ehrhardt, H; Jeremias, I; Maurer, M; Stahnke, K; Wachter, F | 1 |
| Bielecka-Kowalska, A; Bieniek, A; Cuchra, M; Dziki, L; Kowalski, M; Majsterek, I; Markiewicz, L; Mlynarski, W; Pastorczak, A; Sliwinski, T; Stanczyk, M; Szemraj, J; Trelinska, J | 1 |
| Debeljak, M; Dolžan, V; Erčulj, N; Jazbec, J; Kotnik, BF | 1 |
| Bruun, GH; Cheng, C; Corydon, TJ; Evans, WE; Fan, Y; Giacomini, KM; Mikkelsen, TS; Pui, CH; Ramsey, LB; Relling, MV; Rosner, GL; Scheet, P; Sparreboom, A; Treviño, LR; Vattathil, S; Yang, W | 1 |
| Jacobsen, JH; Nersting, J; Schmiegelow, K | 1 |
| Abd-El-Latif, LM; Abd-El-Latif, MM; Hassanein, SM; Hassanin, OM; Ramadan, NI | 1 |
| Mamoudou, AD; Nadaraja, S; Rosthoej, S; Schroeder, H; Thomassen, H; Wehner, PS | 1 |
| Abedin, S; Kapoor, G; Sinha, R | 1 |
| Duan, J; Hou, Z; Huang, Y; Li, H; Liu, H; Liu, M; Wu, KK; Yang, W; Zhang, Y | 1 |
| Chiabai, MA; Lins, TC; Pereira, RW; Pogue, R | 1 |
| Elsner, K; Haase, R; Körholz, D; Kramm, CM; Mauz-Körholz, C; Merkel, N; Stiefel, M | 1 |
| Hu, X; Xu, L; Yang, L | 1 |
| Gostic, WJ; Merryman, R; Neuberg, D; O'Brien, J; Sallan, SE; Silverman, LB; Stevenson, KE | 1 |
| de Beaumais, TA; Jacqz-Aigrain, E | 1 |
| Mathews, CK | 1 |
| Lewis, FM; Murdoch, BE; Perry, ML | 1 |
| Abish, S; Alos, N; Atkinson, S; Barr, R; Cabral, DA; Cairney, E; Couch, R; Cummings, EA; Dix, DB; Fernandez, CV; Grant, RM; Halton, J; Hay, J; Israels, S; Laverdière, C; Lentle, B; Lewis, V; Matzinger, M; Miettunen, PM; Ramsay, T; Rauch, F; Rodd, C; Shenouda, N; Siminoski, K; Stein, R; Stephure, D; Taback, S; Ward, LM; Williams, K; Wilson, B | 1 |
| Bloomfield, CD; DeAngelo, DJ; Johnson, JL; Kolitz, JE; Larson, RA; Marcucci, G; McDonnell, D; Mrózek, K; Powell, BL; Stock, W; Stone, RM; Vardiman, JW; Westervelt, P; Wetzler, M | 1 |
| Adams, DR; Jones, CR; Saddic, N; Yankura, J | 1 |
| Abella, E; Amigo, ML; Barrios, M; Bravo, P; Brunet, S; García, O; González-Campos, J; Hernández-Rivas, JM; Montesinos, P; Ribera, JM | 1 |
| Digumarti, R; Dorababu, P; Gundeti, S; Kutala, VK; Linga, VG; Nagesh, N; Naushad, SM; Reddanna, P | 1 |
| Carey, M; Hockenberry, MJ; Krull, KR; Miketova, P; Moore, IM | 1 |
| Devidas, M; Gaynon, PS; Hunger, SP; Mattano, LA; Nachman, JB; Sather, HN; Seibel, NL; Steinherz, PG | 1 |
| Cheng, C; Conklin, HM; Krull, KR; Pei, D; Pui, CH; Reddick, WE | 1 |
| Abali, EE; Banerjee, D; Bertino, JR; Felczak, K; Gounder, M; Johnson-Farley, N; Kerrigan, JE; Lin, H; Pankiewicz, KW; Roussel, B; Scotto, KW | 1 |
| Li, TY; Li, XL; Liao, QC; Liu, ST; Qiu, JC; Zhang, Y | 1 |
| Kondo, E | 1 |
| Harada, M; Kamimura, S; Kojima, H; Moritake, H; Nao-I, N; Nunoi, H; Shimonodan, H; Sugimoto, T | 1 |
| Apibal, S; Hongeng, S; Koomdee, N; Pakakasama, S | 1 |
| Becker, A; Drescher, A; Jaehde, U; Panetta, JC; Pui, CH; Relling, MV; Rühs, H | 1 |
| Bauters, T; Belin, P; Benoit, Y; de Moerloose, B; Lammens, T; Robays, H | 1 |
| Fan, CM; Foster, BK; Hui, SK; Xian, CJ | 1 |
| Ballesteros, J; Garcia-Orad, A; Lopez-Lopez, E; Martin-Guerrero, I | 1 |
| Chastagner, P; Contet, A; Mansuy, L; Parentelli, AS; Phulpin-Weibel, A; Trechot, P | 1 |
| Bertino, JR; Tedeschi, PM; Vazquez, A | 1 |
| Hu, WW; Nuriding, H; Yan, M | 1 |
| Bond, J; Goulden, N; Hough, R; Mitchell, C; Moppett, J; Vora, A | 1 |
| Braszko, J; Grabowska, A; Holownia, A; Krawczuk-Rybak, M; Muszynska-Roslan, K; Protas, PT | 1 |
| Ahmed, TM; Eissa, DS | 1 |
| Csordas, K; Eipel, OT; Erdelyi, DJ; Hegyi, M; Kovacs, GT; Muller, J | 1 |
| Buchanan, GR; Camitta, B; Devidas, M; Joyce, MJ; Pollock, BH | 1 |
| Ballesteros, J; Garcia de Andoin, N; Garcia-Miguel, P; Garcia-Orad, A; Lopez-Lopez, E; Navajas, A; Piñan, MA; Sanchez de Toledo, J | 1 |
| Cheng, C; Devidas, M; Evans, WE; Fan, Y; Hunger, SP; Loh, M; Martin, PL; Panetta, JC; Pui, CH; Ramsey, LB; Relling, MV; Smith, C; Winick, NJ; Yang, W | 1 |
| Fukano, R; Inada, H; Ishii, E; Itonaga, N; Kawakami, K; Kawano, Y; Kikuchi, M; Matsuzaki, A; Moritake, H; Nagatoshi, Y; Nakayama, H; Okamura, J; Suenobu, S; Suminoe, A; Yanai, F | 1 |
| Çankal, A; Gözmen, S; Irken, G; Ören, H; Tüfekçi, Ö; Vergin, C; Yüksel, F | 1 |
| Goulden, N; Hancock, J; Hough, R; Mitchell, C; Richards, S; Rowntree, C; Vora, A; Wade, R | 1 |
| Barraco, D; Candoni, A; Fanin, R; Pirracchio, A; Simeone, E | 1 |
| Hop, WC; Lequin, MH; MuinckKeizer-Schrama, SM; van der Shuis, IM; van Kuijk, C; Van Rijn, RR; van ven Huevel-Eibrink, MM | 1 |
| Evans, WE; Panetta, JC; Pui, CH; Relling, MV; Wall, A | 1 |
| Blazek, B; Gajdos, P; Hrstková, H; Jabali, Y; Kopecná, L; Mihál, V; Mydlil, J; Slavík, Z; Starý, J; Trka, J; Vávra, V; Zahálka, F | 1 |
| Aricò, M; Benigno, V; Locatelli, F; Orlando, MA; Russo, D; Ziino, O | 1 |
| Balogh, E; Jakab, Z; Kappelmayer, J; Karászi, E; Kiss, C; Oláh, E | 1 |
| Apak, H; Celkan, T; Kuruoglu, S; Ozkan, A; Yildiz, I; Yuksel, L | 1 |
| Boyett, JM; Brenner, TL; Dervieux, T; Evans, WE; Hancock, ML; Hon, YY; Pui, CH; Relling, MV; Ribeiro, RC; Rivera, GK; Sandlund, JT; Zhou, Y | 1 |
| Bringelsen, K; Hsi, ED; Trupiano, JK | 1 |
| Korinthenberg, R; Niemeyer, C; Schneider, A | 1 |
| Kulkarni, S; Mehta, J; Powles, R; Singhal, S; Sirohi, B; Tait, D; Treleaven, J | 1 |
| Nakaseko, C; Nishimura, M; Saito, Y; Uehara, T; Yokota, A | 1 |
| Bonetti, F; Conter, V; Fagioli, F; Favre, C; Giorgiani, G; Lanino, E; Locatelli, F; Messina, C; Pession, A; Porta, F; Rondelli, R; Sacchi, N; Uderzo, C; Zecca, M | 1 |
| Chiasson, S; Costea, I; Krajinovic, M; Laverdière, C; Moghrabi, A | 1 |
| Bucsky, P; Goepel, W; Gottschalk, S; Schultz, C; Strunk, T | 1 |
| Evans, WE; Panetta, JC; Pui, CH; Relling, MV; Ribeiro, R; Rivera, GK; Rubnitz, J; Sandlund, JT; Yanishevski, Y | 1 |
| Atabay, B; Cevik, N; Duman, M; Gülen, H; Irken, G; Oren, H; Uçar, C; Uysal, K; Yilmaz, S | 1 |
| Dudkin, SD; Dyshlevaia, ZM; Fechina, LG; Hartmann, R; Henze, H; Karachunskiĭ, AI; Lebedev, VV; Miakova, NV; Rudneva, AE; Rumiantsev, AG; Shamardina, AV; Timakov, AM; Timofeeva, VN; Trubina, NM; Varfolomeeva, SR | 1 |
| Aleĭnikova, OV; Dudkin, SD; Dyshlevaia, ZM; Fechina, LG; Hartmann, R; Henze, H; Karachunskiĭ, AI; Lebedev, VV; Miakova, NV; Rudneva, AE; Rumiantsev, AG; Shamardina, AV; Timakov, AM; Timofeeva, VN; Trubina, NM; Varfolomeeva, SIu | 1 |
| Clausen, N; Jonmundsson, GK; Madsen, HO; Nyvold, C; Ryder, LP; Schmiegelow, K; Seyfarth, J; Wesenberg, F | 1 |
| Ahonen, A; Harila-Saari, A; Jauhiainen, J; Lanning, M; Lehtinen, S; Pääkkö, E; Pyhtinen, J; Torniainen, P | 1 |
| Colosimo, C; Guzzetta, F; Iuvone, L; Mariotti, P; Riccardi, R; Ruggiero, A | 1 |
| Nachman, JB | 1 |
| Crocci, AJ; Lopes, LF; Minicucci, EM | 1 |
| Arcese, W; Bacigalupo, A; Bunjes, D; Frassoni, F; Gluckman, E; Koc, H; Labopin, M; Ringdén, O; Rocha, V; Schaefer, UW; Schattenberg, A; Willemze, R | 1 |
| Avrahami, G; Cohen, IJ; Kornreich, L; Shuper, A; Stark, B; Yaniv, I | 1 |
| Bürger, B; Kühl, J; Löning, L; Mann, G; Reiter, A; Riehm, H; Schrappe, M; Zimmermann, M | 1 |
| Bostrom, BC; Erdmann, GR; Gaynon, PS; Gold, S; Heerema, NA; Hutchinson, RJ; Johnston, K; La, MK; Provisor, AJ; Sather, HN; Sensel, MR; Trigg, ME | 1 |
| Amara, H; Ben Youssef, Y; el Omri, H; Ennabli, S; Kraiem, I; Skouri, H | 1 |
| Henderson, RD; Nicol, AJ; Rajah, T; Read, SJ | 1 |
| English, MW; Karandikar, SS; Sastry, J | 1 |
| Benkirane, N; Berraho, A; Charif, CM; Loughzail, K | 1 |
| Bostrom, BC; Erdmann, GR; Kamen, BA | 1 |
| Chan, GC; Cheung, AY; Chik, KW; Ha, SY; Lee, AC; Li, CK; Ling, SC; Luk, CW; Shing, MM; Yuen, HL | 1 |
| Bächli, EB; Fehr, T; Jacky, E | 1 |
| Hirschfeld, S; Ho, PT; Pazdur, R; Smith, M | 1 |
| Barikbin, B; Ehsani, A; Feizy, V; Namazi, MR | 1 |
| Inukai, T; Kinoshita, A; Kondoh, K; Kurosawa, Y; Manabe, A; Nakazawa, S; Sugita, K; Suzuki, T | 1 |
| Björk, O; Glomstein, A; Gustafsson, G; Keiding, N; Kristinsson, J; Mäkipernaa, A; Rosthøj, S; Schmiegelow, K; Szumlanski, C; Sørensen, TM; Weinshilboum, R | 1 |
| Corbacioglu, S; Eber, S; Gungor, T; Hummerjohann, J; Niggli, F | 1 |
| Cetin, M; Yetgin, S | 1 |
| Cheng, C; Cheok, MH; Downing, JR; Evans, WE; Naeve, CW; Pui, CH; Relling, MV; Yang, W | 1 |
| Ar, CM; Ferhanoglu, B; Forta, H; Necioglu, D; Ongören, S; Uzel, B | 1 |
| Clarke, M; Gaynon, P; Hann, I; Harrison, G; Masera, G; Peto, R; Richards, S | 1 |
| Behrentz, M; Björk, O; Forestier, E; Hjorth, L; Höglund, P; Jarfelt, M; Jönsson, P; Lönnerholm, G; Skärby, T | 1 |
| Brandwein, J; Gupta, V; Kamel-Reid, S; Lipton, JH; Messner, HA; Minden, MD | 1 |
| Lee, AC; Li, CH; Wong, YC | 1 |
| Boyett, J; Dervieux, T; Evans, WE; Hancock, ML; Pui, CH; Relling, MV; Ribeiro, RC; Rivera, GK; Sandlund, JT | 1 |
| Bogdanović, A; Colović, M; Janković, G; Kraguljac, N; Suvajdzić, N | 1 |
| Kaliszewski, J; Kitszel, A; Krawczuk-Rybak, M; Wołczyński, S | 1 |
| Kaliszewski, J; Kitszel, A; Krawczuk-Rybak, M | 1 |
| Becker, CM; Chitambar, CR; Drexler, HG; Efferth, T; Gebhart, E; Humeny, A; Miyachi, H; Sauerbrey, A; Steinbach, D; Zintl, F | 1 |
| Cheng, C; Cook, EH; Das, S; Griener, J; Hudson, M; Kishi, S; Pei, D; Pui, CH; Relling, MV; Rubnitz, J; Sandlund, JT | 1 |
| Chen, Y; Han, W; Hong, H; Huang, X; Lu, D | 1 |
| Bertino, JR; Gaynon, PS; Gorlick, R; La, M; Levy, AS; Moscow, JA; Sather, HN; Sowers, R; Steinherz, PG; Uckun, FM | 1 |
| Filippa, DA; Mora, J; Qin, J; Wollner, N | 1 |
| CARPENTER, CM; MEYERS, RL; MILLER, JN | 1 |
| BELMUSTO, L; HANANIAN, J; NIGOGOSYAN, G; OWENS, G; REGELSON, W | 1 |
| Blazek, B; Cerná, Z; Dembická, D; Gajdos, P; Hak, J; Hrstková, H; Hrusák, O; Jabali, Y; Kopecná, L; Mihál, V; Mydlil, J; Pospísilová, D; Procházková, D; Ptoszková, H; Slavík, Z; Starý, J; Timr, P; Trka, J; Vávra, V; Zahálka, F | 1 |
| Chiou, SS; Kou, HS; Kuo, CY; Wu, DC; Wu, HL; Wu, SM | 1 |
| Jayabose, S; Kutscher, M; Sandoval, C; Tenner, M | 1 |
| Corazza, F; Demulder, A; Ferster, A; Fondu, P; Hermans, C; Sariban, E | 1 |
| Bennett, JM; Cassileth, PA; Hoagland, HC; Leong, T; Oken, MM; Paietta, E; Wiernik, PH | 1 |
| Chan, YL; Chik, KW; Chu, WC; Howard, RG; Li, CK; Metreweli, C; Roebuck, DJ; Yeung, DK | 1 |
| Asgedom, G; Cario, G; Lauten, M; Schrappe, M; Welte, K | 1 |
| French, S; Gershman, G; Tang, W; Ziring, D | 1 |
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| Balcerska, A; Balwierz, W; Chybicka, A; Derwich, K; Dobaczewski, G; Juszczak, K; Kowalczyk, J; Krauze, A; Luszczyńska, A; Matysiak, M; Moryl-Bujakowska, A; Pawelec, K; Pawińska, K; Płoszyńska, A; Skoczeń, S; Sońta-Jakimczyk, D; Styczyńskii, J; Swiatkiewicz, V; Tomaszewska, R; Wachowiak, J; Wiśniewska-Slusarz, H; Wysocki, M | 1 |
| Balwierz, W; Cwliklińska, M; Nowak, J; Stanuch, H | 1 |
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| Geyer, LJ; Hawkins, DS; Taylor, JA; Winter, L | 1 |
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| Hijiya, N; Howard, SC; Hudson, MM; Jeha, S; Kyzer, EP; Panetta, JC; Pui, CH; Razzouk, BI; Relling, MV; Ribeiro, RC; Rubnitz, JE; Sandlund, JT; Zhou, Y | 1 |
| Greenberg, ML; Hitzler, JK; Kennedy, K; Maze, R; Nathan, PC; Spiegler, BJ; Weitzman, S | 1 |
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| Auclerc, MF; Baruchel, A; Couillault, G; Demeocq, F; Dufourg, MN; Gandemer, V; Landman-Parker, J; Leblanc, T; Leverger, G; Levy, P; Michel, G; Perel, Y; Schmitt, C; Tabone, MD; Vannier, JP | 1 |
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| Clarke, LE; Goldfeder, KL; James, WD; Katz, KA; Levin, JM; Loren, AW | 1 |
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| Benoit, Y; Campbell, M; Conter, V; Dibar, E; Gadner, H; Magyarosy, E; Masera, G; Reiter, A; Riehm, H; Schrappe, M; Silvestri, D; Stary, J; Valsecchi, MG; Zimmermann, M | 1 |
| Iijima, K; Iki, S; Kida, M; Nakasone, H; Taoka, K; Urabe, A; Usuki, K; Yoshimi, A | 1 |
| Boulad, F; Castro-Malaspina, H; Chiu, M; Heller, G; Hsu, K; Jakubowski, A; Kernan, NA; O'Reilly, RJ; Papadopoulos, EB; Perales, MA; Prockop, S; Small, TN; Wilton, A; Young, JW | 1 |
| Devidas, M; Ge, Y; Haska, CL; LaFiura, K; Linda, SB; Liu, M; Matherly, LH; Taub, JW; Thomas, R | 1 |
| Cheng, C; Cook, EH; Das, S; Evans, WE; French, D; Frudakis, T; Hijiya, N; Kishi, S; Pei, D; Pui, CH; Relling, MV; Rizzari, C; Rosner, GL | 1 |
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| Chayama, K; Endo, M; Hara, JI; Hasegawa, D; Hashii, Y; Hori, H; Horibe, K; Isogai, M; Matsumoto, K; Miyaji, R; Nishimura, S; Sato, A; Suzuki, N; Tanizawa, A; Uami, I; Umeda, K; Wakazono, Y; Yagi, K; Yoshida, M | 1 |
| Bell, BA; Camitta, B; Carroll, AJ; Chauvenet, AR; Devidas, M; Kurtzberg, J; Linda, SB; Martin, PL; Pettenati, MJ; Pullen, J; Shuster, JJ | 1 |
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| Bahlis, NJ; Balogh, A; Brown, CB; Chaudhry, MA; Geddes, M; Larratt, L; Quinlan, D; Russell, JA; Savoie, ML; Stewart, DA; Storek, J; Turner, AR | 1 |
| Aribi, A; Bueso-Ramos, C; Cortes, J; Estey, E; Estrov, Z; Faderl, S; Garcia-Manero, G; Giles, F; Kantarjian, H; Kebriaei, P; O'Brien, S; Pierce, S; Ravandi, F; Thomas, D | 1 |
| Daenen, S; de Wolf, JT; Kluin-Nelemans, HC; van den Berg-de Ruiter, E; van Imhoff, GW; Vellenga, E | 1 |
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| Cole, PD; Drachtman, RA; Drapala, DA; Glod, J; Kamen, BA; Lisi, S; Masterson, M; Smith, AK; Zebala, JA | 1 |
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| Coconi-Linares, LN; Garcés-Eisele, J; Reyes-Núñez, V; Ruiz-Argüelles, GJ | 1 |
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| de Jonge, R; Huang, L; Pieters, R; Tissing, WJ; van Zelst, BD | 1 |
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| Cheng, KK | 1 |
| Berdel, WE; Bieker, R; Mesters, RM; Müller-Tidow, C; Rudat, A; Schliemann, C; Schmidt, E; Thoennissen, NH; Zühlsdorf, M | 1 |
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| Chang, J; Crowther, D; Morgenstern, GR; Pettengell, R; Radford, JA; Rowlands, M; Scarffe, JH; Testa, NG; Woll, PJ; Young, R | 1 |
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| Barredo, JC; Evans, WE; Laver, J; Priest, DG; Pui, CH; Relling, MV; Synold, TW | 1 |
| Boyett, JM; Crist, WM; Evans, WE; Mahmoud, H; Pui, CH; Relling, MV; Rivera, GK; Sandlund, JT; Synold, TW | 1 |
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| Chelstrom, LM; Gunther, R; Myers, DE; Simon, J; Tuel-Ahlgren, L; Uckun, FM | 1 |
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| Bruchelt, G; Carmine, TC; Evans, P; Evans, R; Halliwell, B; Handgretinger, R; Niethammer, D | 1 |
| Dommann-Scherrer, C; Honegger, HP; Jacky, E; Jost, LM; Maurer, R; Sauter, C; Stahel, RA | 1 |
| Annino, L; Crescenzi, S; Ferrari, A; Mandelli, F; Romani, C | 1 |
| Behm, FG; Boyett, JM; Hancock, ML; Krance, RA; Mahmoud, HH; Pui, CH; Raimondi, SC; Relling, MV; Ribeiro, RC; Sandlund, JT | 1 |
| Groot-Loonen, JJ; Lippens, RJ; Otten, BJ; Stoelinga, GB; van t' Hof, MA | 1 |
| Arreguín, L; Benítez, H; Bernaldez, R; Díaz, S; Farfán, J; Gaona, A; Juan, L; Martínez, MC; Velásquez, L | 1 |
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| Baker, CJ; Camacho, M; Haber, M; Kavallaris, M; Madafiglio, J; Norris, MD; Stewart, BW; White, L | 1 |
| Bleyer, A | 1 |
| Aricò, M; Basso, G; Colella, R; Conter, V; Messina, C; Miniero, R; Mori, PG; Rizzari, C; Testi, AM; Valsecchi, MG | 1 |
| Atmore, K; Carpenter, PJ; Castro, R; Fairclough, D; Isquith, P; Lussier, F; Romero, I; Schiller, M; Tarbell, NJ; Waber, DP | 1 |
| Davies, HA; Didcock, E; Didi, M; Ogilvy Stuart, AL; Shalet, SM; Wales, JK | 1 |
| Bosco, I; Teh, A | 1 |
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| Asakawa, H; Higano, S; Imaizumi, M; Matsumoto, K; Sakamoto, K; Sato, A; Tada, K; Takahashi, S | 1 |
| Eviatar, L; Grossman, R; Karayalycin, G; Lanzkowsky, P; Maytal, J; Schaul, N; Shende, AC; Yusuf, FH | 1 |
| Bökkerink, JP; De Abreu, RA; Keuzenkamp-Jansen, CW; Trijbels, JM; vd Heijden, MA | 1 |
| Cortes, J; Freireich, EJ; Kantarjian, HM; Keating, MJ; O'Brien, SM; Pierce, S | 1 |
| Bartlett, NL; Horning, SJ; Kwak, LW | 1 |
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| Bertino, JR; Elisseyeff, Y; Göker, E; Lin, JT; Niedzwiecki, D; Schweitzer, BI; Steinherz, P; Tan, C; Tong, WP; Trippett, T | 1 |
| Eden, OB; Eynaud, P; Perry, P; Slavotinek, A; Steel, CM; Thomson, A | 1 |
| Greco, FA; Greer, JP; Hainsworth, JD; Waits, TM | 1 |
| Evans, WE; Liu, Q; McLeod, HL; Pui, CH; Relling, MV | 1 |
| Inoue, T; Ishihara, T; Ishii, E; Koga, H; Matsuzaki, A; Miyazaki, S; Nibu, K; Take, H; Ueda, K; Yanai, F | 1 |
| Burns, CP; Davey, FR; Dodge, RK; Duggan, D; Frankel, SR; Larson, RA; Lee, EJ; Schulman, P; Sobol, RE; Stone, RM | 1 |
| Camitta, BM; Civin, CJ; Ganick, DJ; Kamen, BA; Lauer, SJ; Leventhal, BG; Mahoney, DH; Shuster, JJ; Steuber, CP | 1 |
| Bertino, JR; Dennig, D; Elisseyeff, Y; Göker, E; Jagiello, C; Kheradpour, A; Lacerda, JF; O'Reilly, RJ | 1 |
| Hołowiecki, J; Kachel, L; Krawczyk, M; Krzemień, S; Rudzka, E; Wojnar, J | 1 |
| Bailey, CC; Duggal, MS; O'Sullivan, EA | 1 |
| Kadin, M; Kersey, JH; King, D; Krailo, MD; Meadows, AT; Morse, M; Rosenstock, J; Steinherz, PG; Tubergen, DG | 1 |
| Davies, HA; Lilleyman, JS | 1 |
| Benz-Bohm, G; Berthold, F; Jung, G; Lanfermann, H | 1 |
| Bernini, JC; Chappell, WB; Fort, DW; Griener, JC; Kamen, BA; Kane, BJ | 1 |
| Balla, G; Békési, A; Kovács, I; Oláh, VA; Tóth, A | 1 |
| Artaza, M; Burgos, R; Cavero, MA; Maicas, C; Oteo, JF; Pulpón, LA; Rubio, JA; Serrano-Fiz, S; Silva, L; Téllez, G | 1 |
| Chessells, JM | 1 |
| Buck, S; Gimotty, P; Matherly, LH; Proefke, SA; Ravindranath, Y; Rosowsky, A; Taub, JW; Wong, SC; Wright, JE | 1 |
| Bailey, C; Chessells, JM; Richards, SM | 1 |
| Cambier, N; Cony-Makhoul, P; Delmer, A; François, S; Harousseau, JL; Leprisé, PY; Ostronoff, M; Patte, C; Rigal-Huguet, F; Soussain, C | 1 |
| D'Incalci, M; Donelli, MG; Masera, G; Perlangeli, V; Robatto, A; Rossi, MR; Zucchetti, M | 1 |
| Crist, WM; Hancock, ML; Hudson, M; Kun, L; Mahmoud, H; Mulhern, RK; Pui, CH; Ribeiro, RC; Rivera, GK; Sandlund, JT | 1 |
| Gadner, H; Henze, G; Ludwig, WD; Müller-Weihrich, S; Parwaresch, R; Reiter, A; Riehm, H; Sauter, S; Schrappe, M; Sykora, KW | 1 |
| Cantor, NL; Kaleita, TA; MacLean, WE; Noll, RB; Novak, LJ; Ruymann, F; Schwartz, E; Stehbens, JA; Waskerwitz, M; Whitt, JK | 1 |
| Bartolucci, AA; Gordon, DS; Martelo, O; Omura, GA; Vogler, WR | 1 |
| Roman, DD; Sperduto, PW | 1 |
| Belz, S; Frickel, C; Henze, G; Nau, H; Wolfrom, C | 1 |
| den Ottolander, GJ; Falkenburg, JH; Fibbe, WE; Kluin-Nelemans, JC; Starrenburg, CW; van der Burgh, JF; Willemze, R; Zijlmans, JM | 1 |
| Büssing, A; Mertens, R; Rubbert, F | 1 |
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| Christensen, JK; Hasle, H; Helgestad, J; Jacobsen, BB; Kamper, J | 1 |
| Welborn, JL | 1 |
| Jenney, M | 1 |
| Brouwers, P; Ferronato, L; Huisman, J; Jankovic, M; Kamphuis, R; Kingma, A; Mor, W; Valsecchi, MG; Van Dongen-Melman, J; Van Veldhuizen, A | 1 |
| Mazingue, F; Mechinaud, F; Millot, F; Rubie, H; Thyss, A | 1 |
| Byrne, J; Fears, TR; Haupt, R; Meadows, AT; Mills, JL; Nicholson, HS; Robison, LL; Zeltzer, LK | 1 |
| Advani, IM; Gopal, R; Nadkarni, K; Pai, S; Pai, V; Parikh, P; Raje, N; Saikia, T; Vaidya, S | 1 |
| Arrighini, A; Carli, M; Cordero di Montezemolo, L; Fears, TR; Fossati Bellani, F; Garrè, ML; Guazzelli, C; Jankovic, M; Rosso, P; Terracini, B | 1 |
| Inoue, T; Ishii, E; Koga, H; Matsuzaki, A; Miyake, K; Miyazaki, S; Nibu, K; Take, H; Ueda, K; Yanai, F | 1 |
| Catovsky, D; Horton, C; Mehta, J; Milan, S; Powles, R; Tait, D; Treleaven, J | 1 |
| Schmiegelow, K; Schmiegelow, M; Schrøder, H | 1 |
| Fujimoto, T; Koizumi, S | 1 |
| Adair, S; Camitta, B; Civin, C; Lauer, SJ; Leventhal, B; Mahoney, D; Munoz, L; Shuster, JJ; Steuber, P; Strother, D | 1 |
| Kamen, BA; Weitman, SD; Winick, NJ | 1 |
| Kryzhanovskiĭ, OI; Lebedev, VV; Mazo, IB; Rumiantsev, AG; Sallakh, S; Tabet, S; Vladimirskaia, EB; Zamarraeva, NV | 1 |
| Ayers, D; Crom, WR; Evans, WE; Fairclough, D; Pui, CH; Relling, MV; Rodman, JH | 1 |
| Cheatham, BD; Henry, RJ | 1 |
| Aschan, J; Ringdén, O | 1 |
| Ito, H; Kimura, Y; Nakamura, H; Nomura, N; Otaka, M; Sakai, N; Shirota, T; Suzuki, A; Toyama, K; Uchida, H | 1 |
| Crist, WM; Harris, MB; Krance, RA; Land, VJ; Pinkel, D; Pullen, DJ; Ravindranath, Y; Shuster, JJ | 1 |
| Chan, LC; Chan, TK; Chiu, EK; Kwong, YL; Liang, R; Lie, A; Todd, D | 1 |
| Borgström, B; Dahllöf, G; Forsberg, CM; Rozell, B | 1 |
| Dhondt, JL; Farriaux, JP; Hayte, JM; Mazingue, F; Millot, F | 1 |
| Gerritsen, EJ; Haraldsson, A; van den Berg, H; Vossen, JM | 1 |
| Celakovská, J; Chládek, J; Chládková, J; Hak, J; Martínková, J; Parízková, E; Sispera, L; Slavík, Z | 1 |
| Fujimoto, T; Fukushima, T; Hata, T; Kawaguchi, Y; Kuriyama, K; Matsuo, Y; Saitoh, M; Tabata, S; Tsushima, H; Yakata, Y | 1 |
| Abe, A; Kato, H; Matsuoka, A; Matsushita, T; Tahara, T; Takeo, T; Towatari, M; Toyozumi, H; Yamamoto, K; Yamazaki, T | 1 |
| Gururangan, S; Horner, M; Marina, NM; Rodman, JH | 1 |
| Bertrand, Y; Etienne, MC; Milano, G; Rubie, H; Thyss, A | 1 |
| al Kawi, MZ; Bohlega, S; Clink, HM; Coates, R; Ernst, P; McLean, DR; Omer, S | 1 |
| Bessho, F; Hayashi, Y; Kamoshita, S; Kinumaki, H; Kobayashi, M; Yokota, S | 1 |
| Aricò, M; Egeler, RM; Favara, BE; Heitger, A; Neglia, JP; Nesbit, ME | 1 |
| Arlt, I; Bührer, C; Fengler, R; Hartmann, R; Henze, G; Loewke, M; Schober, S | 1 |
| Hutchinson, RM; Murphy, P; Parker, A | 1 |
| Blatt, J; Howrie, DL; Mirro, J; Phebus, C; Wollman, MR | 1 |
| Collis, CH; Gale, RF; Gandhi, L; Hamon, MD; Macdonald, ID; Prentice, HG; Skeggs, DB; Smith, OP | 1 |
| Durrant, IJ; Richards, SM | 1 |
| Haile, WH; Heitzman, KJ; McCloskey, DE; McGuire, JJ; Piper, JR; Russell, CA | 2 |
| Gibson, BE; Lennard, L; Lilleyman, JS; Nicole, T | 1 |
| Borsi, JD; Koós, R; Kovács, GT; Paál, C; Schuler, D; Somló, P | 1 |
| Beck, O; Björk, O; Hayder, S; Peterson, C; Skoglund, KA; Söderhäll, S; Wennberg, M | 1 |
| Fu, J; Hu, Y; Qin, H; Zhang, Y; Zhao, X | 1 |
| Akashi, K; Eto, T; Gondo, H; Harada, M; Hayashi, S; Nagafuji, K; Takamatsu, Y; Taniguchi, S; Teshima, T; Yamasaki, K | 1 |
| Beardsley, GP; Bunni, MA; Leffert, JJ; Pavlovic, M; Pizzorno, G; Priest, DG; Russello, O | 1 |
| Angeles, SM; Matherly, LH | 1 |
| Champagne, J; Dresse, MF; Infante-Rivard, C; Leclerc, JM; Rivard, GE | 1 |
| Hobbie, WL; Hollen, PJ | 1 |
| Azar, C; Benson, L; Dutcher, JP; Garl, S; Gucalp, R; Markus, S; Paietta, E; Weinberg, V; Wiernik, PH | 1 |
| Zittoun, J | 1 |
| Büchner, T; Freund, M; Heil, G; Hiddemann, W; Hoelzer, D; Löffler, H; Ludwig, WD; Maschmeyer, G; Thiel, E; Völkers, B | 1 |
| Andrea, M; Aranega, V; Brandalise, S; Odone, V; Pereira, W; Zanichelli, M | 1 |
| Bailey, CC; Curzon, ME; Duggal, MS; Hart, P; O'Sullivan, EA | 1 |
| Goldman, J; Morleda, J; Mughal, T | 1 |
| Armata, J; Bogusławska-Jaworska, J; Chybicka, A; Cyklis, R; Grześkowiak-Melanowska, J; Radwańska, U; Sońta-Jakimczyk, D; Swiatły, A; Wieczorek, M | 1 |
| de Muinck Keizer-Schrama, SM; Drop, SL; Hählen, K; Hokken-Koelega, AC; Stijnen, T; van Doorn, JW | 1 |
| Lai, KK | 1 |
| Falletta, JM; Hvizdala, E; Katz, JA; Murphy, SB; Schwenn, M; Shuster, J | 1 |
| Belanger, R; Boileau, J; Bonny, Y; Kassis, J; Lacombe, M; Lalonde, Y; Lavallee, R; Perreault, C; Roy, DC; von Bueltzingsloewen, A | 1 |
| Biggs, JC; Champlin, RE; Deeg, HJ; Dicke, K; Gale, RP; Horowitz, MM; Masaoka, T; Powles, RL; Ringdén, O; Sondel, P | 1 |
| Aurer, I; Bogdanić, V; Kovacević-Metelko, J; Labar, B; Maravić, N; Mrsić, M; Nemet, D; Radman, I; Zupancić-Salek, S | 1 |
| Hsieh, YL; Huang, JK; Liang, DC; Lin, JC; Lin, ST; Shih, SL; Shu, SG; Tsai, YM; Wong, LY; Yang, CP | 1 |
| Coccia, PF; Gilchrist, GS; Hammond, GD; O'Brien, RT; Sather, HN; Tubergen, DG; Waskerwitz, MJ | 2 |
| Cassuto-Viguier, E; Jambou, P; Milano, G; Renée, N; Soler, C; Thyss, A | 1 |
| Adair, S; Camitta, BM; Casper, JT; Civin, CI; Graham, M; Kiefer, G; Lauer, SJ; Leventhal, BG; Mahoney, DH; Shuster, JJ | 1 |
| Carotenuto, M; Fusilli, S; Ladogana, S; Modoni, S; Musto, P; Salcuni, G | 1 |
| Ikeda, K; Kubota, Y; Murata, M; Nagai, M; Ohnishi, H; Sasaki, K; Takahara, J; Tanaka, T; Taoka, T; Tasaka, T | 1 |
| Chan, H; Clarke, R; Pencharz, PB; Stallings, VA; Vaisman, N; Weitzman, SS | 1 |
| Brühmüller, S; Fengler, R; Hartmann, R; Henze, G; Ingwersen, A; Wolfrom, C | 1 |
| Asami, K; Fujimoto, T; Kaneko, Y; Kawai, S; Ninomiya, T; Nishikawa, K; Oka, T; Takaue, Y; Tsuchiya, T; Zha, Z | 1 |
| Berman, E; Gaynor, J; Gee, T; Kempin, S; Kritz, A; Little, C; Scheinberg, D; Sogoloff, H; Telford, P; Weiss, M | 1 |
| Clavell, LA; Cohen, HJ; Dalton, V; Donnelly, M; Gelber, RD; Sallan, SE; Tarbell, NJ; Tobia, F | 1 |
| Canal, P; Chatelut, E; Couderc, F; Nertz, M; Nouadje, G; Puig, P; Rubie, H | 1 |
| Evans, WE; Liu, Q; Masson, E; Pui, CH; Relling, MV; Sandlund, JT; Schuetz, JD; Synold, TW | 1 |
| Prendergast, M; Winter, E | 1 |
| Evans, WE; Masson, E; Pui, CH; Relling, MV; Sandlund, JT; Schuetz, JD; Synold, TW | 1 |
| Albertioni, F; Beck, O; Eksborg, S; Peterson, C; Pettersson, B; Poulsen, JH; Rask, C; Schroeder, H | 1 |
| Dunphy, CH; Kitchen, S; Saravia, O; Velasquez, WS | 1 |
| Adamson, PC; Johnson, CM; McManus, MJ; O'Marcaigh, AS; Patterson, MC; Smithson, WA; Widemann, BC | 1 |
| Beare, S; Steward, WP | 1 |
| Bocci, G; Danesi, R; Del Tacca, M; Di Paolo, A; Favre, C; Innocenti, F; Loru, B; Macchia, P; Nardi, M; Nardini, D | 1 |
| Mempel, K; Pfetsch, M; Reiter, A; Riehm, H; Schrappe, M; Schwab, G; Welte, K | 1 |
| Blatt, J; Lange, BJ; Meadows, AT; Sather, HN | 1 |
| Annino, L; Mandelli, F; Rotoli, B | 1 |
| De Vaan, GA; Hählen, K; Kamps, WA; Solbu, G; Suciu, S; Van der Does-Van der Berg, A; Van Leeuwen, EF; Van Wering, ER; Veerman, AJ | 1 |
| Gökbuget, N; Hoelzer, D | 1 |
| Bleyer, WA; Breneman, JC; Chappell, R; Cherlow, JM; Gaynon, PS; Grossman, NJ; Hammond, D; Johnstone, HS; Kersey, JH; Sather, HN; Steinherz, PG; Trigg, ME | 1 |
| Blakley, RL; Chunduru, SK; Pui, CH; Sleep, SE; Sorrentino, BP; Spencer, HT | 1 |
| Blom, HJ; Bökkerink, JP; De Abreu, RA; Keuzenkamp-Jansen, CW; Trijbels, JM | 1 |
| Behm, F; Berard, C; Bowman, WP; Carroll, A; Cook, B; Griffin, T; Head, D; Link, M; Murphy, S; Pullen, J; Shuster, JJ | 1 |
| Barbui, T; Bassan, R; Di Bona, E; Fabris, P; Lambertenghi-Deliliers, G; Lerede, T; Pogliani, E; Porcellini, A; Rambaldi, A; Rossi, G | 1 |
| Cleary, ML; Davis, RE; Kamel, OW; Soslow, RA; Warnke, RA | 1 |
| Bradstock, K; Brisco, J; Enno, A; Hughes, E; McCaul, K; Morley, AA; Neoh, SH; Sykes, PJ; Szer, J | 1 |
| Bartram, CR; Borkhardt, A; Harbott, J; Janka-Schaub, G; Janssen, JW; Kabisch, H; Lampert, F; Ludwig, WD; Ratei, R; Reinisch, I; Repp, R; Riehm, H; Ritterbach, J; Schlieben, S; Schrappe, M; Zimmermann, M | 1 |
| Bleyer, WA; Ingram, LC; Jardine, LF | 1 |
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| Benaim, E; Crist, WM; Hudson, MM; Liu, Q; Pui, CH; Ribeiro, RC; Rivera, GK | 1 |
| Haave, I; Moe, PJ; Nygaard, R; Seidel, H | 1 |
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| Altundağ, MK; Benekli, M; Firat, D; Güllü, IH; Kadayifçi, A; Savaş, MC; Tekuzman, G | 1 |
| Horton, C; Mehta, J; Powles, R; Singhal, S; Tait, D; Treleaven, J | 1 |
| Beck, JD; Haupt, K; Hertzberg, H; Meier, W; Uberall, MA; Wenzel, D | 1 |
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| Borowitz, M; Bowman, WP; Buchanan, GR; Farrow, A; Jacaruso, D; Kamen, BA; Shuster, JJ; Winick, N | 1 |
| Beck, JD; Hertzberg, H; Langer, T; Meier, W; Uberall, MA; Wenzel, D | 1 |
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| Beck, JD; Haupt, K; Hertzberg, H; Huk, WJ; Langer, T; Meier, W; Ueberall, MA; Wenzel, D | 1 |
| Albertioni, F; Beck, O; Eksborg, S; Palm, C; Peterson, C; Rask, C; Schroeder, H | 1 |
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| Buendia, MT; Lozano, JM; Terselich, G; Viscaino, MP | 1 |
| Boyett, JM; Brecher, ML; Freeman, AI; Glicksman, AS; Holland, JF; Leventhal, BG; Sinks, LF | 1 |
| Ahonen, AK; Harila-Saari, AH; Himanen, AS; Lanning, BM; Pääkkö, EL; Pyhtinen, J; Torniainen, PJ; Vainionpää, LK | 1 |
| Akatsuka, J; Fujisawa, K; Hoshi, Y; Hurusato, M; Kobayashi, H; Maekawa, K; Uchiyama, H; Urashima, M | 1 |
| Buchholz, B; Eisenbarth, J; Frei, E; Ludwig, R; Weigand, M | 1 |
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| Albertioni, F; Peterson, C; Rask, C; Schroeder, H | 1 |
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| Aumann, V; Dörffel, W; Kluba, U; Mittler, U; Mohnike, K; Timme, J; Vorwerk, P | 1 |
| Benoit, Y; Bertrand, Y; Boutard, P; Brock, P; Chantraine, JM; Ferster, A; Lutz, P; Marguerite, G; Mazingue, F; Mechinaud, F; Michel, G; Munzer, M; Norton, L; Otten, J; Philippe, N; Plantaz, D; Plouvier, E; Rialland, X; Robert, A; Solbu, G; Suciu, S; Thyss, A; Vilmer, E | 1 |
| Adamson, PC; Balis, FM; Montello, MJ; Murphy, RF; O'Brien, M; Sorensen, JM; Widemann, BC | 1 |
| Matherly, LH; Taub, JW | 2 |
| Fong, KW; Lee, AC; So, KT; Wong, KW | 1 |
| Behrendt, H; Langeveld, NE; van den Berg, H; Veenhof, CH | 1 |
| Balter, R; Degani, D; Franchini, M; Marradi, P; Meneghini, V; Perona, G; Ricetti, M; Tecchio, C; Todeschini, G; Zanotti, R | 1 |
| Bowman, WP; Buchanan, GR; Farrow, AC; Winick, NJ; Zwiener, RJ | 1 |
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| Bernáldez-Ríos, R; Espinoza-Hernández, L; Fajardo-Gutíerrez, A; Martínez-García, MC; Mejía-Arangure, JM; Rodríguez-Zepeda, MC | 1 |
| Jacobsen, G; Lindqvist, B; Moe, PJ; Nygaard, R; Seidel, H; Slørdal, L | 1 |
| Boyett, JM; Evans, WE; Pui, CH; Relling, MV | 1 |
| Fossen, A | 1 |
| Bertino, JR; Ercikan, E; Gorlick, R; Longo, GS; Tong, WP | 1 |
| Hale, G; Horton, C; Mehta, J; Powles, R; Shepherd, V; Singhal, S; Treleaven, J; Waldmann, H | 1 |
| Aricó, M; Basso, G; Conter, V; Dördelmann, M; Ludwig, WD; Masera, G; Reiter, A; Riehm, H; Rizzari, C; Schrappe, M; Valsecchi, MG; Zimmermann, M | 1 |
| Beck, JD; Berger-Jones, K; Hertzberg, H; Huk, WJ; Korinthenberg, R; Langer, T; Meier, W; Skirl, G; Strassburg, HM; Ueberall, MA; Wenzel, D | 1 |
| Bouabdallah, R; Broustet, A; Cahn, JY; Cazin, B; Cony-Makhoul, P; Cordonnier, C; Delannoy, A; Dreyfus, F; Fière, D; Gay, C; Michaux, JL; Sadoun, A; Sebban, C; Vernant, JP | 1 |
| Bagheri, H; Bénézet, S; Canal, P; Chatelut, E; Montastruc, JL; Nguyen, L; Pourrat, J; Rigal-Huguet, F; Robert, A | 1 |
| Evans, WE; Harrison, PL; Lascombes, F; Mahmoud, HH; Mondesir, JM; Pui, CH; Relling, MV; Ribeiro, RC; Rivera, GK; Sandlund, JT; Struxiano, A | 1 |
| Lennard, L; Lilleyman, JS; Welch, JC | 1 |
| Azuma, E; Higashigawa, M; Hirayama, M; Hori, H; Ido, M; Kawasaki, H; Sakurai, M | 1 |
| Gokcora, N; Gucuyener, K; Gursel, T; Karabacak, NI; Ozturk, G | 1 |
| Donnelly, MJ; Gelber, RD; Gilliland, DG; McLean, TW; Sallan, SE; Silverman, LB; Tarbell, NJ | 1 |
| Harila-Saari, AH; Kovala, TT; Lanning, BM; Tolonen, EU; Vainionpää, LK | 1 |
| Boyett, JM; Brecher, ML; Dubowy, R; Freeman, A; Glicksman, AS; Hill, JM; Holland, JC; Holland, JF; Jones, D; Kornblith, AB; Kung, F; Lenherr, B; Maurer, H | 1 |
| Camitta, B; Lauer, SJ; Mahoney, DH; Nitschke, R; Shuster, J; Steuber, CP; Winick, N | 1 |
| Bottiglieri, T; Griener, JC; Kamen, BA; Quinn, CT | 1 |
| Boyett, JM; Crom, WR; Evans, WE; Pui, CH; Relling, MV; Rodman, JH | 1 |
| Kelkar, P; Lövblad, K; Ozdoba, C; Ramelli, G; Remonda, L; Schroth, G | 1 |
| Kobayashi, H; Ohnuma, T; Takemura, Y | 1 |
| Cherlow, JM; Gaynon, PS; Lukens, JN; Nachman, J; Sather, HN; Sensel, MG; Trigg, ME; Wolff, L | 1 |
| Andersen, JB; Schmiegelow, K; Szumlanski, C; Weinshilboum, RM | 1 |
| Akabutu, JJ; Bernstein, ML; Bowen, T; Camitta, B; Cooley, L; Kamen, BA; Lauer, SJ; Look, AT; Mahoney, DH; Payment, C; Pullen, DJ; Shuster, JJ; Vuchich, MJ; Watson, MS; Whitehead, VM | 1 |
| April, F; Meneghini, V; Perona, G; Pizzolo, G; Ricetti, MM; Solero, P; Tecchio, C; Todeschini, G; Veneri, D; Zanotti, R | 1 |
| Chavez, CM; Holdsworth, MT; Raisch, DW; Winter, SS | 1 |
| Clelland, J; Hann, I; Surtees, R | 1 |
| Behm, FG; Boyett, JM; Caver, TE; Flynn, PM; Hudson, MM; Hurwitz, JL; Pui, CH; Slobod, KS; Tassie, TL; Turner, EV; Webster, RG | 1 |
| Amemiya, Y; Furukawa, Y; Hoshino, M; Imagawa, S; Izumi, T; Kawano, C; Kirito, K; Komatsu, N; Kuribara, R; Miura, Y; Miyazato, A; Muroi, K; Omine, K; Otsuki, T; Shimizu, R; Suzuki, T; Tabata, M; Takahashi, H; Takatoku, M; Terui, Y; Tomizuka, H; Toshima, M; Tsunoda, J; Uchida, M; Yoshida, M | 1 |
| Camitta, B; Lauer, SJ; Mahoney, DH; Nitschke, R; Shuster, JJ; Steuber, CP; Winick, N | 1 |
| Chan, GC; Chan, LC; Chiu, DC; Ha, SY; Lau, YL; Ma, SK | 1 |
| Holcenberg, JS; Kamen, BA; Winick, N | 1 |
| Agaoglu, L; Anak, S; Aytepe, Z; Devecioglu, O; Gedikoglu, G; Guven, Y; Ozerkan, AG; Sepet, E; Yalman, N | 1 |
| Behm, FG; Evans, WE; Hancock, ML; Head, DR; Kun, LE; Mahmoud, HH; Pui, CH; Relling, MV; Ribeiro, RC; Rivera, GK; Rubnitz, JE; Sandlund, JT | 1 |
| Bailey, C; Burrett, J; Chessells, J; Hann, I; Hill, F; Richards, S | 1 |
| Albertioni, F; Bentzen, SM; Peterson, C; Rask, C; Schroeder, H | 1 |
| Clelland, J; Heales, S; Surtees, R | 1 |
| Evans, WE; Harrison, PL; Pui, CH; Relling, MV; Ribeiro, RC; Rivera, GK; Rubnitz, JE; Sandlund, JT; Thompson, SJ | 1 |
| Eden, OB; Hann, IM; Hill, FG; Richards, SM | 1 |
| Cáp, J; Foltinová, A; Jamárik, M; Kaiserová, E; Mojzesová, A; Sejnová, D | 1 |
| Amemiya, Y; Hatake, K; Izumi, T; Kuribara, R; Miura, Y; Muroi, K; Suzuki, T; Yoshida, M | 1 |
| Hukku, B; Matherly, LH; Pullen, J; Ravindranath, Y; Taub, JW; Williamson, M; Wong, SC; Zhang, L | 1 |
| Donaldson, M; Gibson, B; Ralston, JM; Reilly, JJ; Ventham, JC | 1 |
| Bekkenk, MW; Jansen, G; Mauritz, R; Mini, E; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ | 1 |
| Ames, MM; Balis, FM; Bleyer, WA; Ge, J; Gilchrist, GS; Holcenberg, JS; Murphy, RF; Poplack, DG; Sather, HN; Tubergen, DG; Waskerwitz, MJ; Zimm, S | 1 |
| Hum, M; Kamen, BA; Smith, A; Winick, NJ | 1 |
| Borowitz, MJ; Camitta, B; Cheo, DL; Graham, ML; Harrison, MP; Kamen, BA; Land, VJ; Leventhal, BG; Pinkel, DP; Pullen, DJ; Shuster, JJ; Steuber, P; Whitehead, VM | 1 |
| Aricò, M; Basso, G; Biondi, A; Conter, V; De Rossi, G; Di Tullio, MT; Lo Nigro, L; Masera, G; Messina, C; Miniero, R; Mori, PG; Pession, A; Rizzari, C; Rondelli, R; Santoro, N; Silvestri, D; Tamaro, P; Testi, A; Valsecchi, MG | 1 |
| Frei, E | 1 |
| Schmiegelow, K | 1 |
| Benzel, EC; Ciesielski, KT; Hart, BL; Lesnik, PG; Sanders, JA | 1 |
| Anami, K; Asami, K; Chin, M; Fujimoto, T; Hatae, Y; Hirota, T; Horikoshi, Y; Ito, M; Iwai, A; Kaneko, Y; Katano, N; Kataoka, S; Kikuchi, M; Koizumi, S; Miyawaki, T; Mugisima, H; Nakayama, M; Nishikawa, K; Osima, K; Suzumiya, J; Taga, T; Tanaka, A; Tsurusawa, M; Watanabe, A; Yanase, T | 1 |
| Mauger, DC; Skeen, JE | 1 |
| Hołowiecki, J; Kopera, M; Krawczyk-Kuliś, M; Kruzel, T; Markiewicz, M; Wojciechowska, M; Wojnar, J | 1 |
| Jansen, G; Kaspers, GJ; Mauritz, R; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ | 1 |
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| Cheung, AY; Chik, KW; Lai, HD; Lam, TK; Li, CK; Ng, MH; Shing, MM; Yuen, PM | 1 |
| Adamson, PC; Balis, FM; Gillespie, AJ; Moser, AM; Poplack, DG | 1 |
| Belkov, VM; Evans, WE; Krynetski, EY; Masson, E; Mathew, S; Pui, CH; Raimondi, S; Relling, MV; Schuetz, JD; Yanishevski, Y | 1 |
| Creutzig, U; Hählen, K; Jansen, G; Kaspers, GJ; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ | 1 |
| Børsting, S; Glomstein, A; Hapnes, C; Hellebostad, M; Holen, A; Madsen, B; Moe, PJ; Nielsen, B; Nygaard, R; Steen-Johnsen, J; Stokland, T; Wefring, KW | 1 |
| Anami, K; Asami, K; Fujimoto, T; Furuyama, T; Gushiken, T; Hatae, Y; Hirota, T; Ijichi, O; Iwai, A; Kanegane, H; Katano, N; Kawano, Y; Kikuta, A; Koizumi, S; Mimaya, J; Miyake, M; Mugishima, H; Nishi, K; Nishikawa, K; Sekine, I; Takeda, T; Tsurusawa, M; Watanabe, A; Yamamoto, Y; Yatabe, M | 1 |
| Boyett, JM; Evans, WE; Hancock, ML; Pui, CH; Relling, MV | 1 |
| Glomstein, A; Gustafsson, G; Jonmundsson, G; Mellander, L; Nysom, K; Ringdén, O; Saarinen-Pihkala, UM; Schroeder, H | 1 |
| Kaleita, TA; MacLean, WE; Reaman, GH; Sather, HN; Whitt, JK | 1 |
| Perkkiö, M; Riikonen, P; Seuri, R; Vornanen, M | 1 |
| Baggott, JE; Johanning, GL | 1 |
| Advis, P; Becker, A; Beresi, V; Cabrera, ME; Campbell, M; Paez, E; Quintana, J; Rojas, J; Salgado, C; Tapia, S; Vargas, L; Zolezzi, P | 1 |
| Desai, K; Goel, A; Muzumdar, DP | 1 |
| Chrzanowska, M; Duczmal-Cichocka, B; Fiet, J; Kolecki, P | 1 |
| Aozasa, K; Arita, N; Hiraga, S; Kohmura, E; Ohnishi, T; Oku, Y; Sato, M; Taki, T; Yamamoto, K; Yoshimine, T | 1 |
| Conter, V; Jankovic, M; Milani, M; Riva, L; Rizzari, C; Sala, A | 1 |
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| Hanrahan, LR; Phillips, DL; Sallah, S | 1 |
| Chen, LS; Koh, S; Kovanlikaya, A; Nelson, MD | 1 |
| Abe, T; Aoki, I; Araki, K; Deura, K; Fukuda, H; Fukuhara, S; Hotta, T; Kobayashi, T; Konda, S; Kozuru, M; Matsumoto, M; Mikuni, C; Nagai, M; Niimi, M; Oyama, A; Sai, T; Shimoyama, M; Shirakawa, S; Tajima, K; Tobinai, K; Toki, H; Yamaguchi, N | 1 |
| Gadner, H; Gaiger, A; Haas, OA; Heinze, G; Linnerth, B; Lion, T; Mann, G; Schmid, D; Tisljar, K | 1 |
| Canterbury, A; Clarke, E; Cornish, JM; Goodman, S; Green, A; Hale, G; Hunt, L; Lankester, A; Marks, DI; Oakhill, A; Pamphilon, DH; Steward, CG; Waldmann, H | 1 |
| Cortes, J; Fayad, L; Kantarjian, H; Keating, M; O'Brien, S | 1 |
| Hegge, IR; Jansen, G; Kaspers, GJ; Pieters, R; Rots, MG; Veerman, AJ | 1 |
| Banerjee, D; Bertino, JR; Cole, P; Gorlick, R; Hochhauser, D; Li, WW; Longo, G | 1 |
| Aguayo, A; Cortes, J; Kantarjian, H; Keating, M; Pierce, S; Thomas, D | 1 |
| Autret-Leca, E; Breilh, D; Lamagnère, JP; Le Guellec, C; Odoul, F; Paintaud, G; Saux, MC | 1 |
| Aarbakke, J; Giverhaug, T; Loennechen, T | 1 |
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| Hongo, T; Horibe, K; Komada, Y; Matsuyama, T; Nishimura, Y; Sakurai, M; Takao, A | 1 |
| Byers, JF; Cash, M; Schafhauser, B | 1 |
| Filatov, LB; Konstantinova, TS; Shalaev, VA | 1 |
| Abramov, A; Attias, D; Ballin, A; Burstein, Y; Cividalli, G; Rechavi, G; Sharon, R; Stark, B; Sthoeger, D; Zaizov, R | 1 |
| Bueno, J; Julià, A; Villalba, T; Zuazu, J | 1 |
| Hibi, S; Hojo, M; Imashuku, S; Kajimoto, H; Naya, M | 1 |
| Gadner, H; Henze, G; Ludwig, WD; Parwaresch, R; Reiter, A; Riehm, H; Schellong, G; Schirg, E; Schrappe, M; Tiemann, M; Zimmermann, M | 1 |
| Ozbek, N; Tuncer, AM; Yetgin, S | 1 |
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| Fukushima, T; Hamano, K; Koike, K; Maki, T; Okada, Y; Sumazaki, R; Tsuchida, M | 1 |
| Fasching, K; Gadner, H; Panzer, S; Panzer-Grümayer, ER; Schneider, M | 1 |
| Aärimaa, T; Harila-Saari, A; Kähkönen, M; Korhonen, T; Metsähonkala, L; Minn, H; Norvasuo-Heilä, MK; Ruotsalainen, U; Salmi, TT; Solin, O; Suhonen-Polvi, H; Utriainen, T | 1 |
| Gajjar, A; Link, A; Mahmoud, H; Pui, CH; Relling, MV; Wall, AM | 1 |
| Camitta, B; Lauer, S; Mahoney, DH; Nitschke, R; Shuster, JJ; Steuber, CP | 1 |
| Eden, OB; Gibson, B; Hann, I; Hill, F; Kinsey, S; Lilleyman, J; Mitchell, C; Richards, S; Vora, A | 1 |
| Armata, J; Balcerska, A; Balwierz, W; Bogusławska-Jaworska, J; Bubała, H; Chybicka, A; Filiks-Litwin, B; Gorczyńska, E; Juszczak, K; Kowalczyk, J; Kołecki, P; Lukowska, K; Matysiak, M; Rokicka-Milewska, R; Rola-Kurc, E; Sońta-Jakimczyk, D; Stencel, D; Strojny, W; Wachowiak, J; Wieczorek, M; Wysocki, M; Zelenay, E | 1 |
| Armata, J; Bogusławska-Jaworska, J; Bubała, H; Dłuzniewska, A; Kazanowska, B; Kowalczyk, J; Kołecki, P; Matysiak, M; Rokicka-Milewska, R; Sońta-Jakimczyk, D; Sopyło, B; Stańczak, E; Stefaniak, MJ; Stefańska, K; Wróbel, G | 1 |
| Bessho, F; Hanada, R; Hoshi, Y; Hosoya, R; Ikuta, K; Ishimoto, K; Kaneko, T; Koike, Ki; Maeda, M; Manabe, A; Mori, T; Nakazawa, S; Ohara, A; Ohkawa, Y; Okimoto, Y; Saito, T; Sato, T; Shitara, T; Toyoda, Y; Tsuchida, M; Tsunematsu, Y | 1 |
| Auclerc, MF; Auvrignon, A; Baruchel, A; Bauduer, F; Berthou, C; Bordigoni, P; Demeocq, F; Lamagnere, JP; Landman-Parker, J; Leblanc, T; Legall, E; Leverger, G; Mathey, C; Michel, G; Pautard, B; Perel, Y; Schaison, G; Schneider, P | 1 |
| Andersen, A; Jacobsen, G; Kvaløy, JT; Lindqvist, B; Moe, PJ; Nygaard, R; Seidel, H; Slørdal, L | 1 |
| Bierings, MB; Bruin, MC; Rademaker, CM; Révész, T; van den Bos, C; van Haselen, CW | 1 |
| Choi, D; Seex, K | 1 |
| Kingma, A; Postma, A; Rammeloo, LA; Rekers-Mombarg, L; van Der Does-van den Berg, A | 1 |
| Chen, J; Jiang, S; Li, J | 1 |
| Holdaway, D; Lawrence, B; Raymond-Speden, E; Tripp, G | 1 |
| Henze, G; Janka-Schaub, GE; Jansen, G; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; Van Zantwijk, CH; Veerman, AJ | 1 |
| Frei, E; Graf, N; Weigand, M; Wiessler, M | 1 |
| Estlin, EJ; Hall, AG; Lowis, SP | 1 |
| Adachi, Y; Iki, S; Kazama, K; Urabe, A; Usuki, K | 1 |
| Chan, HL; Jaing, TH; Yang, CH; Yang, LJ | 1 |
| Dempke, W; Schmoll, HJ; von Poblozki, A | 1 |
| Aviner, S; Cohen, IJ; Goshen, Y; Kornreich, L; Shuper, A; Stark, B; Stein, J; Steinmetz, A; Yaniv, I | 1 |
| Behm, FG; Boyett, JM; Campana, D; Coustan-Smith, E; Hancock, ML; Pui, CH; Raimondi, SC; Ribeiro, RC; Rivera, GK; Rubnitz, JE; Sancho, J; Sandlund, JT | 1 |
| Jansen, G; Kaspers, GJ; Peters, GJ; Pieters, R; Rots, MG; Veerman, AJ | 1 |
| Harila-Saari, A; Himanen, S; Lanning, M; Pääkkö, E; Pyhtinen, J; Vanionpää, L | 1 |
| Cole, PD; Kamen, BA | 1 |
| Holen, A; Moe, PJ | 1 |
| Arnold, R; Bartram, CR; Böhme, A; Freund, M; Ganser, A; Gökbuget, N; Hoelzer, D; Kneba, M; Langer, W; Lipp, T; Ludwig, WD; Maschmeyer, G; Messerer, D; Rieder, H; Thiel, E; Weiss, A | 1 |
| Garcia-Manero, G; Kantarjian, HM | 1 |
| Clausen, N; Forestier, E; Glomstein, A; Gustafsson, G; Jonmundsson, G; Mäkipernaa, A; Mellander, L; Nygaard, R; Saarinen-Pihkala, UM; Schmiegelow, K | 1 |
| Chao, TY; Chen, YC; Dai, MS; Ho, CL; Kao, WY | 1 |
| Appelbaum, FR; Balcerzak, SP; Boldt, DH; Head, DR; Kopecky, KJ; Petersdorf, SH; Roy, V; Veith, RW; Wun, T | 1 |
| Halonen, P; Mäkipernaa, A; Salo, MK | 1 |
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| Bretton-Meyer, U; Schmiegelow, K | 1 |
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| Cortes, J | 1 |
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| Balawi, I; El Haddad, A; El Karaksy, H; Meir, H; Nayel, H | 1 |
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| Eden, O; Gibson, B; Hann, I; Harrison, C; Harrison, G; Hill, F; Richards, S; Vora, A | 1 |
| Cociglio, M; Hansel, S; Hillaire-Buys, D; Margueritte, G; Peyriere, H; Poiree, M | 1 |
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| Biagi, E; Conter, V; Lazzareschi, I; Milani, M; Riccardi, R; Ruggiero, A; Sparano, P | 1 |
| Auperin, A; Behrendt, H; Coze, C; Frappaz, D; Leverger, G; Lutz, P; Michon, J; Patte, C; Perel, Y; Raphaël, M; Terrier-Lacombe, MJ | 1 |
| Cataland, SR; Daugherty, CK; Larson, RA; Weseman, EC | 1 |
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| Chan, YL; Chik, KW; Lau, KY; Li, CK; Roebuck, DJ; Yeung, KW; Yuen, MP | 1 |
| Fletcher, BD; Harrison, PL; Kaste, SC; Kennedy, W; Neel, MD; Pui, CH; Razzouk, BI; Relling, MV; Ribeiro, RC; Rubnitz, JE; Sandlund, JT | 1 |
| Bernard, M; Casassus, P; Delain, M; Desablens, B; Guilhot, F; Hunault-Berger, M; Ifrah, N; Jouet, JP; Milpied, N; Sadoun, A | 1 |
| Catts, VS; Farnsworth, ML; Haber, M; Lock, RB; Lutze-Mann, LH; Norris, MD | 1 |
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| Boguslawska-Jaworska, J; Golebiowski, W; Gorczynska, E; Hurkacz, M; Orzechowska-Juzwenko, K; Wiela-Hojenska, A | 1 |
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| Bernstein, ML; Camitta, B; Cooley, L; Lauer, SJ; Look, AT; Mahoney, DH; Payment, C; Pullen, DJ; Shuster, JJ; Vuchich, MJ; Whitehead, VM | 1 |
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| Daniel, M; Demetriou, L; Göbel, U; Kolotas, C; Kurek, R; Martin, T; Schnabel, T; Tonus, C; Zamboglou, N | 1 |
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| Adachi, S; Akiyama, Y; Hamahata, K; Kubota, M; Lin, YW; Nakahata, T; Watanabe, K | 1 |
| Bailey, CC; Chessells, JM; Gibson, BE; Hann, IM; Harrison, G; Hill, FG; Richards, SM | 1 |
| Höllinger, P; Mattle, HP; Schroth, G; Zenhäusern, R | 1 |
| Barcos, M; Bloomfield, CD; Freter, CE; Frizzera, G; Johnson, JL; Lee, EJ; Peterson, BA; Petroni, GR; Schiffer, CA | 1 |
| Gu, L; Ye, H | 1 |
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| Ashihara, E; Fujita, N; Hatsuse, M; Inaba, T; Nakagawa, M; Noda, Y; Ochiai, N; Okano, A; Shimazaki, C; Takahashi, R | 1 |
| Flatley, RM; Gifford, AJ; Haber, M; Liu, XY; Matherly, LH; Norris, M; Ravindranath, Y; Taub, JW; Whetstine, JR; Witt, T | 1 |
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| Anderson, SC; Baquis, GD; Jackson, A; Kirkwood, JR; Monteleone, P | 1 |
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| Haran, M; Klepfish, A; Lurie, Y; Malnick, S; Shtalrid, M | 1 |
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| Dervieux, T; Evans, W; Hancock, M; Pui, CH; Relling, MV | 1 |
| Conn, JS; Fitzgerald, JM; Jackson, GH; Proctor, SJ; Tiplady, CW | 1 |
| Alfaro, EM; Felice, MS; Sackmann-Muriel, F; Zubizarreta, PA | 1 |
| Lewis, V; Piatkowski, J; Rydholm, N; Sauer, M; Steiner, M | 1 |
| Botsonis, A; Moschovi, M; Papadopoulou, AL; Tsangaris, GT; Tzortzatou-Stathopoulou, F | 1 |
| Estlin, EJ | 1 |
| Marwaha, RK; Ray, M; Trehan, A | 1 |
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| Döhner, H; Gabler, A; Haas, R; Hartmann, F; Hensel, M; Ho, AD; Jung, W; Schlenk, RF; Trümper, L; Weber-Nordt, R | 1 |
| Kaspers, GJ; Matherly, LH; Ravindranath, Y; Rots, MG; Taub, JW; Zantwijk, CH | 1 |
| Chessells, JM; Harrison, CJ; Richards, SM; Vora, AJ; Watson, SL | 1 |
| Beck, JD; Hertzberg, H; Langer, T; Martus, P; Meier, W; Ottensmeier, H | 1 |
| Glass, JO; Helton, KJ; Langston, JW; Reddick, WE | 1 |
| Beverloo, HB; Camitta, BM; Evans, WE; Noordhuis, P; Peters, GJ; Pieters, R; Pui, CH; Ramakers-van Woerden, NL; Relling, MV; Rots, MG; van Wering, ER; van Zantwijk, CH; Veerman, AJ | 1 |
| Deelman, BG; Kamps, WA; Kingma, A; Mooyaart, EL; Van Dommelen, RI; Wilmink, JT | 1 |
| Kadan-Lottick, N; Neglia, JP | 1 |
| Advani, SH; Banavali, SD; Bhatia, KG; Magrath, I; Naresh, KN; Soman, CS | 1 |
| Cortes, J; Estrov, Z; Faderl, S; Giles, FJ; Huh, YO; Kantarjian, HM; O'Brien, S; Pierce, S; Ravandi, F; Thomas, D | 1 |
| Damon, L; Linker, C; Navarro, W; Ries, C | 1 |
| Armata, J; Boguslawska-Jaworska, J; Derwich, K; Juszczak, K; Klus, K; Kolecki, P; Kowalczyk, J; Krauze, A; Matysiak, M; Pawelec, K; Pisarek, J; Rokicka-Milewska, R; Skoczen, S; Sońta-Jakimczyk, D; Styczyński, J; Tomaszewska, R; Wisniewska-Slusarz, H; Wysocki, M; Łuszczynska, A | 1 |
| Albertioni, F; Almer, S; Peterson, C; Pettersson, B; Söderhäll, S | 1 |
| Antunes, NL; Lis, E; Rosenblum, M; Souweidane, MM; Steinherz, PG; Wolden, S | 1 |
| Ansoborlo, S; Babin-Boilletot, A; Baruchel, A; Pacquement, H; Patte, C; Plouvier, E; Sakiroglu, C | 1 |
| Bell, R; Forbes, IK; Hurley, TH; Sullivan, JR | 1 |
| Jastrzebska, M; Lukowska, K; Pacholska, J; Paciorkiewicz, W; Rokicka-Milewska, R | 1 |
| Mead, GM; Sweetenham, JW; Whitehouse, JM | 1 |
| Bailly, F; Caillot, D; Carli, PM; Chavanet, P; Devilliers, E; Guy, H; Mugneret, F; Petrella, T; Solary, E; Waldner, A | 1 |
| Bradley, EL; Månsson-Rahemtulla, B; McMillan, TO; Rahemtulla, F; Techanitiswad, T; Wahlin, YB | 1 |
| Bauters, F; Dhondt, JL; Hayte, JM; Millot, F | 1 |
| Berman, E; Elisseyeff, Y; Goker, E; Rosowsky, A; Schlemmer, S; Steinherz, P; Tan, C; Trippett, T; Wachter, M; Wright, JE | 1 |
| Akabutu, J; Carroll, AJ; Esseltine, DW; Lauer, SJ; Look, AT; Mahoney, D; Payment, C; Shuster, JJ; Vuchich, MJ; Whitehead, VM | 1 |
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| Bergerat, JP; Damonte, JC; Dufour, P; Herbrecht, R; Liu, KL; Maloisel, F; Oberling, F; Ortiz, S | 1 |
| Chastagner, P; Dhondt, J; Millot, F; Sommelet, D | 1 |
| Balter, R; Battisti, L; Borgna-Pignatti, C; Caudana, R; Marradi, P | 1 |
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| Hählen, K; Huismans, DR; Loonen, AH; Peters, GJ; Pieters, R; van der Does-van den Berg, A; van Wering, ER; Veerman, AJ | 1 |
| Hann, IM | 1 |
| Cotterill, S; Eden, OB; Gerrard, M; Hann, I; Imeson, J; Pinkerton, CR | 1 |
| Laitinen, J; Lanning, M; Pääkkö, E; Pyhtinen, J; Vainionpää, L | 1 |
| Arya, LS; Choudhry, VP; Krishnamurthy, L; Pati, H; Rath, GK; Saraya, AK | 1 |
| Adachi, S; Akiyama, Y; Hashimoto, H; Kasai, Y; Kubota, M; Mikawa, H; Sano, H; Shimizu, T | 1 |
| Ohnuma, T; Takemura, Y | 1 |
| Balcar-Boroń, A; Kurylak, A; Nowaczyk-Michalak, A; Pilecki, O; Trybuś, L; Wysocki, M | 1 |
| Greeff, MC; Macdougall, LG; McElligott, SE; Poole, JE; Ross, E | 1 |
| Berry, DH; Caldwell, D; Spence, GT; Williams, J; Zolten, AJ | 1 |
| Graf, N; Pees, HW; Radtke, H; Schwamborn, J | 1 |
| Cheo, DL; Graham, ML; Harrison, MP; Kamen, BA; Leventhal, BG; Pullen, DJ; Shuster, JJ; Whitehead, VM | 1 |
| Ferrazzini, G; Giesbrecht, E; Johnson, D; Koren, G; Robieux, I; Sohl, H | 1 |
| Iwai, A; Komazawa, M; Maeda, H; Nagata, K; Ninomiya, T; Nishikawa, K; Ohmiya, A; Ohta, M; Sato, J; Tsuda, Y | 1 |
| Amadori, S; Guglielmi, C; Mandelli, F; Martelli, M; Papa, G | 2 |
| Balcar-Boroń, A; Krzyzanowski, M; Ozyński, T; Pilecki, O; Szadujkis-Szadurski, L; Wysocki, M | 1 |
| Balcar-Boroń, A; Krzyzanowski, M; Nowaczyk-Michalak, A; Ozyński, T; Szadujkis-Szadurski, L; Wysocki, M | 1 |
| Muller-Runkel, R; Vijayakumar, S | 1 |
| Crist, WM; Crom, WR; Evans, WE; Groom, S; McLeod, HL; Relling, MV; Rivera, GK; Rodman, JH; Silverstein, K | 1 |
| Fujieda, M; Hisakawa, H; Kubota, H; Kurashige, T; Matsumoto, K; Wakiguchi, H | 1 |
| Forio, I; Giralt, J; Olive, T; Ortega, JJ; Salvador, L; Verges, R | 1 |
| Asami, K; Sasazaki, Y; Utsumi, J | 1 |
| Akiyama, Y; Asato, R; Ito, M; Konishi, J; Kubota, M; Mikawa, H; Miki, Y; Okumura, R | 1 |
| Andrew, M; Barr, RD; Cairney, AE; DeVeber, LL; Halton, J; Pai, KM; Whitton, AC | 1 |
| Bartolucci, AA; Gordon, DS; Martelo, OJ; Omura, GA; Raney, M; Vogler, WR | 1 |
| Abromowitch, M; Bowman, WP; Dahl, GV; Dodge, RK; Evans, WE; Hancock, ML; Ochs, J; Pui, CH; Simone, JV; Williams, DL | 1 |
| Gelber, RD; Kahn, CM; Sallan, SE; Tarbell, NJ; Waber, DP | 1 |
| Bancillon, A; Baruchel, A; Bergeron, C; Leblanc, T; Lejars, O; Lepage, E; Leverger, G; Perel, Y; Schaison, G; Sommelet, D | 1 |
| Bailey, CC; Chessells, JM; Richards, S | 1 |
| Andersen, JW; Bennett, JM; Cassileth, PA; Hoagland, HC; Mazza, JJ; O'Connell, MC; Paietta, E; Wiernik, P | 1 |
| Alessandrino, EP; Bacigalupo, A; Bernasconi, C; Carella, AM; Ficarra, F; Lazzarino, M; Locatelli, F; Morra, E; Pagnucco, G; Resegotti, L | 1 |
| Grexa, E; Kajtár, P; Kardos, M | 1 |
| Eguchi, M; Furukawa, T; Kurosawa, H; Sakakibara, H; Sugita, K | 1 |
| Alfawaz, IM; Matar, KM; Najjar, TA | 1 |
| Essell, JH; Halvorson, RD; Harman, GS; Johnson, RA; Rubinsak, JR; Snyder, MJ; Thompson, JM | 1 |
| Wang, ZH; Yu, ZL | 1 |
| Henningsson, S; Jakobson, AM; Kreuger, A; Moe, PJ; Mortimer, O; Seidel, H | 1 |
| Laitinen, J; Lanning, M; Vainionpää, L | 1 |
| Armata, J; Balwierz, W; Bogusławska-Jaworska, J; Chybicka, A; Cyklis, R; Derulska, D; Duczmal, B; Jackowska, T; Jakowicka, M; Rokicka-Milewska, R | 1 |
| Bogdanić, V; Grgić-Markulin, L; Jakić-Razumović, J; Kalenić, S; Labar, B; Mrsić, M; Nemet, D; Presecki, V; Vrtar, M; Vujasinović, S | 1 |
| Langlands, K; Ludlam, CA; Parker, AC; Russell, L; Turner, ML; Watson, HG | 1 |
| Fairclough, D; Mulhern, RK; Ochs, J | 2 |
| García Zueco, JC; López Gómez, L; Martín Guerrero, Y; Torres Gómez, M | 1 |
| Harada, M; Murakawa, M; Niho, Y; Okamura, T; Otsuka, T; Shibuya, T | 1 |
| Cosolo, W; Siderov, J; Zalcberg, J | 1 |
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| Miyachi, H; Ohnuma, T; Sekiguchi, S; Takemura, Y | 1 |
| Beaulieu, D; Rosenblatt, DS; Shuster, JJ; Vuchich, MJ; Whitehead, VM; Witte, A | 1 |
| Chan, TK; Chiu, E; Ho, FC; Liang, R; Lie, A; Loke, SL; Todd, D | 1 |
| Maca, RD | 1 |
| Bertino, JR; Lin, JT; Niedzwiecki, D; Schweitzer, BI; Steinherz, P; Tan, C; Tao, Y; Tong, WP; Trippett, TM | 1 |
| Drigan, R; Gelber, RD; Spirito, A | 1 |
| Bowman, WP; Buchanan, GR; Jacaruso, D; Kamen, BA; Roach, ES; Rollins, N; Winick, NJ | 1 |
| Bayle, C; Brugières, L; Caillaud, JM; Flamant, F; Hartmann, O; Kalifa, C; Lemerle, J; Patte, C; Valteau-Couanet, D | 1 |
| Bratina, G; Conter, V; D'Angelo, P; Jankovic, M; Masera, G; Rovelli, A; Uderzo, C | 1 |
| Hidaka, S; Hiraoka, A; Kobayashi, M; Matsunashi, T; Nakamura, H; Tejima, H; Tominaga, N; Yoshida, H; Yoshida, S; Yoshimura, M | 1 |
| Hatae, Y; Hatayama, Y; Iizuka, S; Murakami, T; Nakadate, H; Nishi, M; Nobumoto, K; Takeda, T; Wada, I | 1 |
| Sommelet, D | 1 |
| Rumiantsev, AG; Samochatova, EV | 1 |
| Bancillon, A | 1 |
| Lanning, M; Myllylä, V; Risteli, J; Risteli, L; Vainionpää, L | 1 |
| Fujimoto, T; Koizumi, S; Mimaya, J; Ninomiya, T; Ohta, S; Sasaki, K; Takaue, Y; Takeda, T; Utsumi, J | 1 |
| Dhondt, JL; Netter, JC; Petrus, M; Rance, F | 1 |
| Blattner, SR; Clavell, LA; Cohen, HJ; Donahue, K; Donnelly, M; Gelber, RD; Niemeyer, CM; Sallan, SE; Tarbell, NJ | 1 |
| Bender-Götze, C; Dopfer, R; Ebell, W; Ehninger, G; Friedrich, W; Gadner, H; Henze, G; Klingebiel, T; Peters, C; Riehm, H | 1 |
| Borsi, JD; Moe, PJ; Stokland, T; Wesenberg, F | 1 |
| Komiyama, A; Yamada, S | 1 |
| Akutsu, M; Kano, Y; Kasahara, T; Sakamoto, S | 1 |
| Armata, J; Balwierz, W; Bogusławska-Jaworska, J; Chybicka, A; Cyklis, R; Darmal, B; Derulska, D; Jackowska, T; Jakowicka, M; Rokicka-Milewska, R | 1 |
| Holowiecki, J; Kachel, L; Lawniczek, T; Pajak, J; Rudzka, E | 1 |
| Hammond, GD; Kaleita, TA; MacLean, WE; Noll, RB; O'Brien, RT; Stehbens, JA; Waskerwitz, MJ | 1 |
| Amineddine, HA; Chessells, JM; Craft, AW; Long, DR; Mills, S; Pearson, AD; Yule, M | 1 |
| Deforest, A; Ridgway, D; Wolff, LJ | 1 |
| Lanning, M; Risteli, J; Risteli, L; Vainionpää, L | 1 |
| Ozbek, S; Ozşahin, H; Yildiz, I | 1 |
| Anasetti, C; Appelbaum, FR; Beatty, P; Bensinger, W; Buckner, CD; Doney, K; Fefer, A; Fisher, LD; Singer, J; Storb, R | 1 |
| Fengler, R; Hartmann, R; Henze, G; Janka-Schaub, G; Kornhuber, B; Niethammer, D; Riehm, H | 1 |
| Blais, JC; Dhondt, JL; Hayte, JM; Klein, R; Millot, F; Pfleiderer, W | 1 |
| Ablin, AR; Halberg, F; Kramer, JH; Moore, IM; Wara, W | 1 |
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| Crom, WR; Gregory, RE; Pui, CH | 1 |
| Balsom, WR; Blatt, J; Bleyer, WA; Hammond, GD; Heyn, RM; Meadows, AT; Robison, LL; Sather, HN; Sitarz, A | 1 |
| Behrendt, H; Dufillot, D; Gentet, JC; Lamagnère, JP; Otten, J; Patte, C; Pein, F; Philip, T; Rodary, C; Zucker, JM | 1 |
| Blattner, SR; Lynch, E; Schwenn, MR; Weinstein, HJ | 1 |
| Abromowitch, M; Harris, M; Kavanagh, R; Ochs, J; Rivera, GK; Rodman, J; Yalowich, J | 1 |
| Ch'ien, L; Fairclough, D; Mauer, A; Mulhern, R; Ochs, J; Parvey, L; Simone, J; Whitaker, J | 1 |
| Brecher, M; Crist, W; Harris, MB; Krance, RA; Land, VJ; Newman, EM; Pullen, J; Ravindranath, Y; Shuster, JJ; Wimmer, R | 1 |
| Refsum, H; Ueland, PM; Wesenberg, F | 1 |
| Mahoney, DH; Oshman, DG; Yim, YS | 1 |
| Carey, PJ; Hamilton, PJ; Proctor, SJ; Taylor, P | 1 |
| Mulhern, RK; Ochs, J; Williams, JM; Williams, KS | 1 |
| Jonsson, OG; Kamen, BA | 1 |
| Fairclough, DL; Furman, WL; Ingram, LC; Kun, LE; Pui, CH; Rivera, GK; Sandlund, JT | 1 |
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| Budman, DR; Cuttner, J; Davey, F; Henderson, ES; Lee, EJ; Mayer, RJ; Mick, R; Paciucci, PA; Sobol, R; Weiss, RB | 1 |
| Inoue, N; Kakishita, E; Kanemaru, A; Kohsaki, M; Konya, H; Miyazaki, E; Okamoto, T; Takemoto, Y; Tamura, S | 1 |
| Matsuhisa, T; Miyoshi, K; Moriwaki, S; Motoi, M; Naruse, R; Okabe, K; Sakamoto, S; Shimokawa, T; Toki, H; Urayama, H | 1 |
| Albertsson-Wikland, K; Lannering, B; Màrky, I; Mellander, L | 1 |
| Eden, OB; Lilleyman, JS; Peto, J; Richards, S; Shaw, MP | 1 |
| Dhondt, JL; Farriaux, JP; Hayte, JM; Mazingue, F; Millot, F; Taret, S | 1 |
| Breithaupt, H; Hartmann, R; Henze, G; Hepp, R; Wolfrom, C | 1 |
| Brouwers, P; Poplack, D | 1 |
| Christensen, B; Refsum, H; Ueland, PM | 1 |
| Behar, C; Benoit, Y; Deville, A; Dutour, C; Laureys, G; Milano, G; Otten, J; Robert, A; Serre Debeauvais, F; Thyss, A | 1 |
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| De Boben, M; Diedrich, H; Freund, M; Ganser, A; Heil, G; Henke, M; Heyll, A; Hiddemann, W; Knauf, U; Koch, P | 1 |
| Fengler, R; Henze, G; Reiter, A; Riehm, H; Ritter, J | 1 |
| Goebel, U; Graubner, U; Haas, RJ; Janka-Schaub, GE; Juergens, H; Spaar, HJ; Winkler, K | 1 |
| Dörffel, W; Malke, H; Reimann, M; Reuter, G; Zintl, F | 1 |
| Bührer, C; Henze, G; Hofmann, J; Reiter, A; Riehm, H; Schellong, G | 1 |
| Bode, U; Fengler, R; Hartmann, R; Henze, G; Janka, G; Jürgens, H; Riehm, H | 1 |
| Evans, WE; Kavanagh, RL; Ochs, J; Rivera, GK; Rodman, JH; Sunderland, M; Yalowich, J | 1 |
| Balter, R; Borgna-Pignatti, C; Caraballo, R; Colamaria, V; Dalla Bernardina, B; Marradi, P; Mazza, C; Procacci, C | 1 |
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| Howes, A; Mullenix, PJ; Schunior, A; Tarbell, NJ; Tassinari, MS; Zengel, AE | 1 |
| Howes, A; Kernan, WJ; Mullenix, PJ; Schunior, A; Tarbell, NJ; Tassinari, MS; Waber, DP | 1 |
| Atogami, S; Kuriyama, K; Maeda, T; Miyazaki, Y; Murata, K; Nagai, K; Nonaka, H; Satoh, T; Tokunaga, S; Yanagisako, T | 1 |
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| Bakker, MA; Bökkerink, JP; Damen, FJ; De Abreu, RA; Hulscher, MW | 1 |
| Borsi, JD; Moe, PJ; Romslo, I; Sagen, E | 2 |
| Atwood, J; Aur, RJ; Hanna, M; Sabbah, R; Sackey, K; Willoughby, S | 1 |
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| Evans, WE; Pui, CH; Schell, MJ | 1 |
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| Ferrazini, G; Giesbrecht, E; Greenberg, M; Kapelushnik, J; Klein, J; Koren, G; Langevin, AM; Soldin, S; Sulh, H | 1 |
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| Hermans, J; Zwaan, FE | 1 |
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| Charlesworth, M; Ede, GM; Gawler, J; Green, CR; Jamal, GA; Patel, P; Prior, PF; Stevenson, JF; Thakkar, CM; Tucker, J | 1 |
| Imashuku, S; Mizutani, A; Morimoto, A; Morioka, Y; Nakajima, T; Sakata, K; Shimizu, Y; Todo, S; Tsunamoto, K | 1 |
| Lennard, L; Lilleyman, JS | 1 |
| Greenberg, M; Klein, J; Koren, G; Soldin, SJ; Solh, H | 1 |
| Hejl, M; Pulczynska, MK; Schmiegelow, K; Schrøder, H | 1 |
| Kumar, L; Raghunath Rao, D; Rajkumar, T; Sagar, TG; Shanta, V; Usha Devi, CJ | 1 |
| Lifschitz, CH; Mahoney, DH | 1 |
| Deville, A; Etienne, MC; Manassero, J; Milano, G; Thyss, A | 1 |
| Huismans, DR; Leyva, A; Pieters, R; Veerman, AJ | 1 |
| Bertino, JR; Chang, YM; Li, WW; Lin, J; Pizzorno, G | 1 |
| Eden, OB; Shaw, NJ | 1 |
| Albo, VC; Hammond, GD; Leikin, SL; Miller, DR; Sather, H | 1 |
| Meyers, P; Redner, A; Steinherz, P; Tan, C; Wollner, N | 1 |
| Ochs, JJ | 1 |
| Acebedo Lerzundi, G; Javier Manchón, G; Montagut Dueso, JM; Olivé Oliveras, T; Ortega Aramburu, JJ; Torán Fuentes, N | 1 |
| Conter, V; D'Incalci, M; Erba, E; Masera, G; Perlangeli, MV; Rabbone, ML; Sen, S | 1 |
| Bleyer, WA; Coccia, PF; Hammond, GD; Lukens, JN; Miller, DR; Sather, HN; Siegel, SE | 1 |
| Steinherz, PG | 1 |
| Behrendt, H; Hermans, J; Schuwirth, C; van der Does-van den Berg, A; van Leeuwen, EF; van Wering, ER; Verkes, RJ | 1 |
| Jansen, G; Kathmann, I; Rademaker, BC; Rijksen, G; Schornagel, JH; Westerhof, GR | 1 |
| Bodensteiner, JB; Gay, CT; Nitschke, R; Sexauer, C; Wilson, D | 1 |
| Cohen, G; Gitter, KA; Stewart, MW | 1 |
| Fondevila Carlos, G; Milone Gustavo, A; Santiago, P | 1 |
| Adair, S; Camitta, B; Casper, J; Civin, C; Graham, M; Lauer, S; Leventhal, B; Mahoney, D; Munoz, L; Shuster, JJ | 1 |
| Arndt, CA; Balis, FM; Doherty, KM; Jeffries, SL; Lange, B; Luery, N; Murphy, RF; Poplack, DG | 1 |
| Etienne, MC; Grelier, P; Milano, G; Paquis, P; Roche, JL; Schneider, M; Thyss, A | 1 |
| Andrew, M; Barr, RD; Desai, SJ; deVeber, LL; Pai, MK | 1 |
| Allen, RH; Broxson, EH; Kolhouse, JF; Stabler, SP; Stork, LC | 1 |
| Higuchi, S; Honjo, T; Igarashi, H; Ishii, E; Kai, T; Kanemitsu, S; Ueda, K; Yamada, S | 1 |
| Glynn-Barnhart, A; Gregory, RE; Kovnar, E; Murphy, SB; Strother, DR | 1 |
| Bourbotte, M; Jean, R; Khatib, N; Margueritte, G; Rejou, F | 1 |
| Pieters, R; Veerman, AJ | 1 |
| Ablin, AR; Albo, VC; Bleyer, WA; Finklestein, JZ; Gaynon, PS; Grossman, NJ; Littman, PS; Novak, LT; Pyesmany, AF; Steinherz, PG | 1 |
| Berry, D; Crist, W; Doering, E; Fernbach, D; Pullen, J; Shuster, J; van Eys, J; Wharam, M | 1 |
| Cousens, P; Said, J; Stevens, M; Waters, BG | 1 |
| Chevallier, B; Dessemme, P; Flouvat, B; Lagardere, B | 1 |
| Inugami, A; Kanno, I; Komatsu, K; Murakami, M; Ogawa, T; Shishido, F; Uemura, K; Yamaguchi, T | 1 |
| Abromowitch, M; Evans, WE; Fairclough, D; Hustu, HO; Kalwinsky, D; Look, AT; Murphy, SB; Ochs, J; Pui, CH; Rivera, GK | 1 |
| Ashby, M; Atkinson, K; Biggs, JC; Concannon, A; Dodds, A; Downs, K | 1 |
| Arnet, B; Baumgartner, C; Beck, D; Berchtold, W; Bertrand, AM; Bleher, EA; Caflisch, U; Delaleu, B; Feldges, A; Stucki, F | 1 |
| Derulska, D; Rokicka-Milewska, R; Skwarska, E | 1 |
| Garwicz, S; Moëll, C; Westgren, U; Wiebe, T | 1 |
| Aarbakke, J; Kolmannskog, S; Moe, PJ; Prytz, PS; Slørdal, L | 2 |
| Di Bella, D; Lo Bianco, M; Rizzari, C; Russo, A; Schilirò, G | 1 |
| Bjerve, KS; Kolmannskog, S; Moe, PJ; Nygaard, R; Wesenberg, F | 1 |
| Lippens, RJ; Winograd, B | 1 |
| Pulczynska, MK; Schmiegelow, K; Seip, M | 1 |
| Amadori, S; Bagnulo, S; Carli, M; Dini, G; Guazzelli, C; Mandelli, F; Masera, G; Rossi, MR; Zanesco, L; Zurlo, MG | 1 |
| Gustafsson, G; Kreuger, A | 1 |
| Burnelli, R; Mancini, AF; Paolucci, G; Paolucci, P; Pession, A; Rosito, P; Serra, L; Vecchi, V; Vivarelli, F | 1 |
| Clausen, N; Ostergård, E; Pressler, T; Schrøder, H | 1 |
| Antuña García, MJ; Fernández, C; Gudín, G; López Sastre, J; Moro Bayón, C; Rodríguez, R | 1 |
| Eyre, JA; Gardner-Medwin, D; Summerfield, GP | 1 |
| Blatt, J; Finegold, D; Lee, P; Suttner, J | 1 |
| Balis, FM; Doherty, KM; Evans, WE; Jeffries, S; McCully, C; Mirro, J; Murphy, RF; Poplack, DG; Reaman, GH | 1 |
| Fujimoto, T | 1 |
| Berry, DH; Prince, MT; Souheaver, GT | 1 |
| Hellwig, C; Poller, C; Reddemann, H | 1 |
| Killander, A; Simonsson, B; Smedmyr, B; Sundström, C | 1 |
| Colly, LP; Peters, WG; Willemze, R | 1 |
| Castel, V; Esquembre, C; Ferris, J; Verdeguer, A | 1 |
| Kolmannskog, S; Moe, PJ; Seip, M; Wesenberg, F | 1 |
| Javier, G; Olivé, T; Ortega, JJ | 1 |
| Choudhary, AJ; Koppikar, SB; Kurkure, PA; Pai, SK; Pai, VR; Sanchetee, SC; Shetty, PA | 1 |
| Fujii, Y; Hongo, T; Igarashi, Y | 1 |
| Ikushima, S; Imashuku, S; Kawakatsu, H; Mizutani, A; Morioka, Y; Sakata, K; Todo, S; Yoshihara, T | 1 |
| Gebauer, E; Nikolić, I; Sterio, M; Vucićević, G; Zalisevskij, G | 1 |
| Ochocka, M; Zelenay, E | 1 |
| Derulska, D; Lewicki, Z; Rokicka-Milewska, R | 1 |
| Cravioto, J; Faisal, AG; Lares-Asseff, I; Paredes, R; Roldán, RM; Taboada, C; Velázquez, M | 1 |
| Bogusławska-Jaworska, J; Erbel-Badeńska, J; Orzechowska-Juzwenko, K; Pejcz, J; Szczepaniak, M; Wiela-Hojeńska, A | 1 |
| Abdalla, A; Badrawy, F; Hamza, R; Khalifa, A | 1 |
111 review(s) available for methotrexate and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
High-dose Methotrexate-induced Acral Erythema in Two Pediatric Patients With Acute Lymphoblastic Leukemia: A 17 Pediatric Case Series of Methotrexate-induced Acral Erythema.
Topics: Antimetabolites, Antineoplastic; Child; Erythema; Foot Dermatoses; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2021 |
Management of CNS Disease in Pediatric Acute Lymphoblastic Leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Central Nervous System Neoplasms; Child; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies | 2022 |
Neurotoxicity Associated with Treatment of Acute Lymphoblastic Leukemia Chemotherapy and Immunotherapy.
Topics: Asparaginase; Child; Drug-Related Side Effects and Adverse Reactions; Humans; Immunologic Factors; Immunotherapy, Adoptive; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations.
Topics: Humans; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Thioguanine | 2022 |
Optimum Methotrexate Exposure in Patients With Suspected or Confirmed CNS Invasive Hematological Malignancies: A Systematic Critical Review.
Topics: Adult; Central Nervous System Neoplasms; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2023 |
Central Nervous System Prophylaxis and Treatment in Acute Leukemias.
Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Cytarabine; Humans; Leukemia, Myeloid, Acute; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
A Comprehensive Review of Neuropsychologic Studies Supports the Concept That Adequate Folinic Acid Rescue Prevents Post Methotrexate Neurotoxicity.
Topics: Bone Neoplasms; Child; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Intrathecal methotrexate induced myelopathy, rare yet serious complication: A case report and review of the literature.
Topics: Adult; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases | 2021 |
The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Female; Humans; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2017 |
Pharmacogenomics in pediatric acute lymphoblastic leukemia: promises and limitations.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Methotrexate; Pharmacogenomic Testing; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2017 |
Pharmacogenomics in acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Asparaginase; Child; Clinical Trials as Topic; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Humans; Mercaptopurine; Methotrexate; Methyltransferases; Molecular Targeted Therapy; Pharmacogenetics; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrophosphatases; Signal Transduction; Vincristine | 2017 |
Glucarpidase treatment for methotrexate intoxication: a case report and review of the literature.
Topics: Acute Kidney Injury; Adult; Antimetabolites, Antineoplastic; gamma-Glutamyl Hydrolase; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins | 2018 |
The Use of Ommaya Reservoirs to Deliver Central Nervous System-Directed Chemotherapy in Childhood Acute Lymphoblastic Leukaemia.
Topics: Antineoplastic Agents; Catheters, Indwelling; Child, Preschool; Drug Delivery Systems; Humans; Infusions, Intraventricular; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2018 |
The role of genetic polymorphisms in the thymidylate synthase (TYMS) gene in methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.
Topics: Alleles; Child; Child, Preschool; Female; Gene Expression Regulation; Genetic Association Studies; Genotype; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Tandem Repeat Sequences; Thymidylate Synthase | 2018 |
Clinical Implications of Methotrexate Pharmacogenetics in Childhood Acute Lymphoblastic Leukaemia.
Topics: Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2019 |
Methotrexate Disposition in Pediatric Patients with Acute Lymphoblastic Leukemia: What Have We Learnt From the Genetic Variants of Drug Transporters.
Topics: Antimetabolites, Antineoplastic; ATP-Binding Cassette Transporters; Child; Humans; Methotrexate; Multidrug Resistance-Associated Protein 2; Organic Anion Transporters; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2019 |
The effect of leucovorin rescue therapy on methotrexate-induced oral mucositis in the treatment of paediatric ALL: A systematic review.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Humans; Infant; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Treatment Outcome; Young Adult | 2019 |
Pharmacogenomic approaches for tailored anti-leukemic therapy in children.
Topics: Alkaloids; Antineoplastic Agents; Benzamides; Child; Glucocorticoids; Hepatic Veno-Occlusive Disease; Humans; Imatinib Mesylate; Mercaptopurine; Methotrexate; Nucleotides; Pharmacogenetics; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thioguanine; Vincristine | 2013 |
How long can folinic acid rescue be delayed after high-dose methotrexate without toxicity?
Topics: Antineoplastic Agents; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B Complex | 2014 |
Pharmacogenetics of methotrexate in acute lymphoblastic leukaemia: why still at the bench level?
Topics: Antimetabolites, Antineoplastic; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Genetic; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Association between reduced folate carrier G80A polymorphism and methotrexate toxicity in childhood acute lymphoblastic leukemia: a meta-analysis.
Topics: Age Factors; Alleles; Antimetabolites, Antineoplastic; Child; Female; Genotype; Humans; Male; Methotrexate; Odds Ratio; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2014 |
[Acute lymphoblastic leukemia].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cyclophosphamide; Dasatinib; Daunorubicin; Doxorubicin; Enzyme Inhibitors; Humans; Imatinib Mesylate; Methotrexate; Middle Aged; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles; Young Adult | 2014 |
Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction.
Topics: Antimetabolites, Antineoplastic; Child; Drug Therapy, Combination; Humans; Maintenance Chemotherapy; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors.
Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Attention; Benzhydryl Compounds; Brain Neoplasms; Central Nervous System Stimulants; Child; Child, Preschool; Cognitive Dysfunction; Comorbidity; Cranial Irradiation; Donepezil; Early Intervention, Educational; Education, Special; Head and Neck Neoplasms; Human Growth Hormone; Humans; Indans; Infant; Injections, Spinal; Memory, Short-Term; Methotrexate; Methylphenidate; Modafinil; Neoplasms; Neurosurgical Procedures; Nootropic Agents; Patient Education as Topic; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Quality of Life; Radiotherapy Dosage; Risk Factors; Severity of Illness Index; Sex Factors; Survivors; Thinking; Wakefulness-Promoting Agents; Young Adult | 2014 |
Pharmacogenetics of childhood acute lymphoblastic leukemia.
Topics: Child; Child, Preschool; Epigenesis, Genetic; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2014 |
Improving treatment of children with acute lymphoblastic leukemia in developing countries through technology sharing, collaboration and partnerships.
Topics: Antimetabolites, Antineoplastic; Child; Developing Countries; Humans; Methotrexate; Neoplasm, Residual; Partnership Practice; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
[Current treatment of pediatric acute lymphoblastic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Child, Preschool; Clinical Trials as Topic; Cytarabine; Dexamethasone; Drug Discovery; Humans; Imatinib Mesylate; Induction Chemotherapy; Mercaptopurine; Methotrexate; Molecular Targeted Therapy; Neoplasm, Residual; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Pyrimidines | 2014 |
Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: A systematic review.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Clinical Protocols; Cognition; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors | 2015 |
Gene polymorphisms in the folate metabolism and their association with MTX-related adverse events in the treatment of ALL.
Topics: Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Liver-Specific Organic Anion Transporter 1; Metabolic Networks and Pathways; Methotrexate; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2015 |
Influence of Cranial Radiotherapy on Outcome in Children With Acute Lymphoblastic Leukemia Treated With Contemporary Therapy.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cranial Irradiation; Humans; Infant; Linear Models; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Retrospective Studies; Secondary Prevention; Treatment Outcome | 2016 |
[Influence of cranial radiotherapy on outcome in children with acute lymphoblastic leukemia treated with contemporary therapy].
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Neoplasms; Child; Child, Preschool; Cranial Irradiation; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome | 2016 |
Minimal residual disease-guided therapy in childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Cyclophosphamide; Daunorubicin; Humans; Induction Chemotherapy; Male; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine | 2017 |
Treatment of acute lymphoblastic leukemia in children and adolescents: peaks and pitfalls.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Diploidy; Disease-Free Survival; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Risk Assessment; Survival Rate; Treatment Outcome; Young Adult | 2008 |
Poor-risk high-grade gliomas in three survivors of childhood acute lymphoblastic leukaemia--an overview of causative factors and possible therapeutic options.
Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Child; Child, Preschool; Cranial Irradiation; Female; Glioma; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy, Adjuvant; Risk Factors; Supratentorial Neoplasms; Survivors; Treatment Outcome | 2009 |
Genomic strategies to improve outcome and individualize therapy in cancer: the paradigm of childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Child; Genetic Association Studies; Genome-Wide Association Study; Humans; Methotrexate; Pharmacogenetics; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Cancer research: from folate antagonism to molecular targets.
Topics: Aminopterin; Folic Acid Antagonists; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2009 |
Pharmacogenomics of pediatric acute lymphoblastic leukemia.
Topics: Child; Cytochrome P-450 CYP3A; Glucocorticoids; Humans; Methotrexate; Methyltransferases; Neoplasm, Residual; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2010 |
Impact of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on methotrexate-induced toxicities in acute lymphoblastic leukemia: a meta-analysis.
Topics: Alleles; Antimetabolites, Antineoplastic; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Intracellular disposition of methotrexate in acute lymphoblastic leukemia in children.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Child; Humans; Mercaptopurine; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
[Feasibility and safety of chemotherapy for acute lymphoblastic leukemia in adolescents and young adults: Interim analysis of JALSG ALL202-U].
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Asparaginase; Clinical Trials, Phase II as Topic; Feasibility Studies; Female; Humans; Maintenance Chemotherapy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Safety; Young Adult | 2012 |
A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia.
Topics: Child; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Drug Interactions; Humans; Leucovorin; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase | 2002 |
Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives.
Topics: Antineoplastic Agents; Azacitidine; Child; Child, Preschool; Drug Approval; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neuroblastoma; Osteosarcoma; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; United States; United States Food and Drug Administration; Vindesine | 2003 |
CNS-directed therapy for childhood acute lymphoblastic leukemia: Childhood ALL Collaborative Group overview of 43 randomized trials.
Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Injections, Spinal; Male; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recurrence; Treatment Outcome | 2003 |
[Results and suggestion from comparing between world excellent protocols of childhood acute lymphoblastic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Cyclophosphamide; Daunorubicin; Humans; Internationality; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Survival Rate; Treatment Outcome; Vincristine | 2003 |
[Resistance mechanisms to Methotrexate].
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2003 |
Defining the appropriate dosage of folinic acid after high-dose methotrexate for childhood acute lymphatic leukemia that will prevent neurotoxicity without rescuing malignant cells in the central nervous system.
Topics: Central Nervous System Neoplasms; Child; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
Pharmacogenetic determinants of outcome in acute lymphoblastic leukaemia.
Topics: Alkylating Agents; Child; Child, Preschool; Drug Resistance, Multiple; Genetic Variation; Glucocorticoids; Humans; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Pharmacogenetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine; Treatment Outcome | 2004 |
Prevalence of leukoencephalopathy in children treated for acute lymphoblastic leukemia with high-dose methotrexate.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Prospective Studies; Risk Factors | 2005 |
High-dose methotrexate in acute lymphoblastic leukemia: where is the evidence for its continued use?
Topics: Animals; Antimetabolites, Antineoplastic; Child; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid Antagonists; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Skeletal morbidity in childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Child; Child, Preschool; Female; Glucocorticoids; Homeostasis; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
[Acute encephalopathy during treatment of lymphoblastosis in children].
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Autopsy; Bone Marrow Examination; Cerebral Infarction; Child, Preschool; Fatal Outcome; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 1976 |
High-dose methotrexate and/or leucovorin rescue for the treatment of children with lymphoblastic malignancies: do we really know why, when and how?
Topics: Antimetabolites, Antineoplastic; Child; Dose-Response Relationship, Drug; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 2005 |
Treatment of acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Child; Combined Modality Therapy; Dexamethasone; Gene Expression Profiling; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Assessment; Stem Cell Transplantation; Survival Analysis | 2006 |
Down syndrome and acute lymphoblastic leukaemia.
Topics: Antineoplastic Agents; Child; Child, Preschool; Down Syndrome; Humans; Infant; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Translocation, Genetic; Treatment Outcome | 2006 |
Neurocognitive effects of treatment for childhood cancer.
Topics: Antineoplastic Agents; Brain Neoplasms; Child; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Developmental Disabilities; Humans; Injections, Spinal; Intellectual Disability; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2006 |
Granular acute lymphoblastic leukemia: a case report and literature review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Cytoplasmic Granules; Dexamethasone; Doxorubicin; Female; Humans; Immunophenotyping; Methotrexate; Middle Aged; Multiple Myeloma; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Treatment Outcome; Vincristine | 2007 |
[Optimal central nervous system directed therapy in childhood acute lymphoblastic leukemia.].
Topics: Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Hypergranular acute lymphoblastic leukemia (ALL). Report of a case and review of the literature.
Topics: Adult; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Bleomycin; Bone Marrow; Gene Rearrangement; Genes, Immunoglobulin; Humans; Immunoglobulin Heavy Chains; Male; Methotrexate; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Antigen, T-Cell, alpha-beta; Receptors, Antigen, T-Cell, gamma-delta; Restriction Mapping; Tegafur | 1993 |
Compliance with oral chemotherapy in childhood lymphoblastic leukaemia.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Attitude to Health; Biological Availability; Child; Humans; Mercaptopurine; Methotrexate; Patient Compliance; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone | 1995 |
[A heart transplant in a patient with doxorubicin-induced myocardiopathy as a complication of the treatment of a lymphoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cardiomyopathy, Dilated; Cyclophosphamide; Daunorubicin; Doxorubicin; Heart Transplantation; Humans; Male; Methotrexate; Myocardium; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Time Factors; Vincristine | 1994 |
Central nervous system directed therapy in acute lymphoblastic leukaemia.
Topics: Adrenal Cortex Hormones; Adult; Child; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Growth Disorders; Humans; Injections, Spinal; Leukemic Infiltration; Male; Meninges; Mental Disorders; Methotrexate; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Quality of Life; Radiation Injuries; Risk Factors; Survival Rate; Survivors; Treatment Outcome | 1994 |
Neuropsychological effects of cranial radiation: current knowledge and future directions.
Topics: Adult; Brain Neoplasms; Carcinoma, Small Cell; Child; Cranial Irradiation; Educational Measurement; Forecasting; Humans; Intelligence; Lung Neoplasms; Memory; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage | 1995 |
Adult acute leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Burkitt Lymphoma; Clinical Trials as Topic; Combined Modality Therapy; Cytarabine; Humans; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Survival Rate; Treatment Outcome | 1994 |
"Above all do no harm:" horizons in pediatric oncology.
Topics: Bone Marrow Transplantation; Child; Combined Modality Therapy; Growth Substances; Humans; Leukemia, Myeloid, Acute; Medical Oncology; Mercaptopurine; Methotrexate; Pediatrics; Phenotype; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life; Recurrence; Survival Rate | 1994 |
[Recent views on the use of methotrexate in the treatment of acute lymphoblastic leukemia in childhood].
Topics: Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1993 |
Acute myelofibrosis terminating in acute lymphoblastic leukemia: case report and review of the literature.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blast Crisis; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 5; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Progression; Flow Cytometry; Humans; Immunophenotyping; Male; Mercaptopurine; Methotrexate; Neoplastic Stem Cells; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Primary Myelofibrosis; Remission Induction; Vincristine | 1996 |
High-dose methotrexate in the treatment of adult acute lymphoblastic leukemia.
Topics: Adult; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
The role of anthracyclines in adult acute lymphoblastic leukaemia.
Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Disease-Free Survival; Doxorubicin; Humans; Idarubicin; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Translocation, Genetic | 1996 |
Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia.
Topics: Adult; Antimetabolites, Antineoplastic; Biological Transport; Biotransformation; Carrier Proteins; Child; Chromosomes, Human, Pair 21; Disease Susceptibility; Disease-Free Survival; Down Syndrome; Drug Resistance, Neoplasm; Folic Acid Antagonists; Half-Life; Humans; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Neoplasm Proteins; Neoplastic Stem Cells; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Reduced Folate Carrier Protein; Remission Induction; Tetrahydrofolate Dehydrogenase | 1996 |
Intrathecal methotrexate overdose.
Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Child, Preschool; Drug Overdose; Female; Humans; Injections, Spinal; Male; Medication Errors; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Time Factors | 1997 |
Does pharmacokinetic variability influence the efficacy of high-dose methotrexate for the treatment of children with acute lymphoblastic leukemia: what can we learn from small studies?
Topics: Antimetabolites, Antineoplastic; Child; Disease-Free Survival; Dose-Response Relationship, Drug; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Risk Assessment | 1997 |
Clinical presentation, hematologic features and treatment outcome of childhood acute lymphoblastic leukemia: a review of 73 cases in Hong Kong.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cranial Irradiation; Disease-Free Survival; Female; Hemorrhage; Hepatomegaly; Hong Kong; Humans; Immunophenotyping; Infant; Karyotyping; Life Tables; Male; Methotrexate; Pain; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Retrospective Studies; Splenomegaly; Survival Analysis; Treatment Outcome | 1997 |
Maintenance chemotherapy of acute lymphoblastic leukemia in children.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1998 |
Successful treatment of intrathecal methotrexate overdose with folinic acid rescue: a case report.
Topics: Antidotes; Antimetabolites, Antineoplastic; Child; Drug Overdose; Humans; Injections, Spinal; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
Mechanisms of methotrexate resistance in acute leukemia. Decreased transport and polyglutamylation.
Topics: Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; gamma-Glutamyl Hydrolase; Humans; Leukemia, Myeloid, Acute; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Disease Progression; Folic Acid; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Risk Factors | 1999 |
The interaction of 6-mercaptopurine (6-MP) and methotrexate (MTX).
Topics: Antimetabolites, Antineoplastic; Child; Drug Interactions; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
[Relapse of acute lymphoblastic leukemia as a retro-orbital mass].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Methotrexate; Orbital Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence | 1999 |
[Effects of chemotherapy on the changes of histology and function of the ovary].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Daunorubicin; Female; Fluorouracil; Humans; Methotrexate; Ovary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 1998 |
Optimizing antimetabolite-based chemotherapy for the treatment of childhood acute lymphoblastic leukaemia.
Topics: Antimetabolites, Antineoplastic; Child; Cytarabine; Drug Administration Schedule; Etoposide; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; Thioguanine | 2000 |
Classification of ex vivo methotrexate resistance in acute lymphoblastic and myeloid leukaemia.
Topics: Acute Disease; Animals; Child; Drug Administration Schedule; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Leukemia, B-Cell; Leukemia, Myeloid; Leukemia, T-Cell; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2000 |
High-dose methotrexate in childhood all.
Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Disease-Free Survival; Drug Administration Schedule; Humans; Infusions, Intravenous; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life; Time Factors | 2000 |
Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Central Nervous System Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Germany; Humans; Immunophenotyping; Injections, Spinal; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Models, Theoretical; Multicenter Studies as Topic; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Remission Induction; Risk; Survival Rate; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome | 2000 |
The hyper-CVAD regimen in adult acute lymphocytic leukemia.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Central Nervous System Neoplasms; Child; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Dexamethasone; Doxorubicin; Drug Administration Schedule; Granulocyte Colony-Stimulating Factor; Humans; Immunization, Passive; Immunophenotyping; Infusions, Intravenous; Injections, Spinal; Karyotyping; Mercaptopurine; Methotrexate; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk; Rituximab; Survival Analysis; Texas; Treatment Outcome; Vincristine | 2000 |
Improving outcome through two decades in childhood ALL in the Nordic countries: the impact of high-dose methotrexate in the reduction of CNS irradiation. Nordic Society of Pediatric Haematology and Oncology (NOPHO).
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2000 |
Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature.
Topics: Adult; Female; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Respiratory Distress Syndrome | 2000 |
Induction therapy of adult acute lymphocytic leukemia without the use of vincristine or prednisone.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Controlled Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Dactinomycin; Doxorubicin; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Multicenter Studies as Topic; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Randomized Controlled Trials as Topic; Recombinant Proteins; Remission Induction; Survival Analysis; Treatment Outcome; Vincristine | 2001 |
Central nervous system involvement in adult acute lymphocytic leukemia.
Topics: Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Child; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Humans; Injections, Spinal; Leukemic Infiltration; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Risk Factors; Salvage Therapy; Survival Analysis; Treatment Outcome | 2001 |
Long-term outcome of treatment with protocols AL841, AL851, and ALHR88 in children with acute lymphoblastic leukemia: results obtained by the Kyushu-Yamaguchi Children's Cancer Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Height; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Growth Disorders; Heart Failure; Hematopoietic Stem Cell Transplantation; Humans; Infant; Japan; Male; Methotrexate; Myelodysplastic Syndromes; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Retrospective Studies; Salvage Therapy; Survival Rate; Survivors; Treatment Outcome; Vincristine | 2001 |
Intrathecal chemotherapy with antineoplastic agents in children.
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Blood-Brain Barrier; Cerebellar Neoplasms; Cerebrospinal Fluid; Child; Cytarabine; Humans; Injections, Spinal; Lymphoma; Medulloblastoma; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thiotepa | 2001 |
Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Infections; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survival Analysis; Thrombocytopenia; Vincristine | 2001 |
[Advances in the study of acute lymphocytic leukemia treated by large dosage of methotrexate].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
Subcutaneous infection with Mycobacterium fortuitum after allogeneic bone marrow transplantation.
Topics: Adult; Bone Marrow Transplantation; Clarithromycin; Combined Modality Therapy; Cyclosporine; Debridement; Drug Therapy, Combination; Female; Graft vs Host Disease; Humans; Immunocompromised Host; Immunosuppressive Agents; Methotrexate; Minocycline; Mycobacterium fortuitum; Mycobacterium Infections, Nontuberculous; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Skin Ulcer; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous | 2001 |
Low relapse rate in children with acute lymphoblastic leukemia after risk-directed therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Bone Marrow Transplantation; Burkitt Lymphoma; Child; Child, Preschool; Combined Modality Therapy; Daunorubicin; Disease-Free Survival; Female; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Genes, Immunoglobulin; Humans; Immunoglobulin Heavy Chains; Infant; Leukemia-Lymphoma, Adult T-Cell; Life Tables; Male; Methotrexate; Neoplasm, Residual; Polymerase Chain Reaction; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Retrospective Studies; Risk; Survival Analysis; Survival Rate; Treatment Outcome; Vincristine | 2001 |
Continuing therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of methotrexate, 6-mercaptopurine and 6-thioguanine.
Topics: Antineoplastic Agents; Child; Humans; Mercaptopurine; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 2001 |
CNS-directed therapy in childhood acute lymphoblastic leukaemia.
Topics: Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy | 1992 |
Disposition of antineoplastic agents in the very young child.
Topics: Age Factors; Antineoplastic Agents; Blood Proteins; Child; Child, Preschool; Doxorubicin; Etoposide; Humans; Infant; Infant, Newborn; Liver; Mercaptopurine; Methotrexate; Neoplasms; Nervous System; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide | 1992 |
[Transient subacute encephalopathy induced by high-dose methotrexate treatment in children with acute lymphoblastic leukemia and malignant lymphoma].
Topics: Adolescent; Brain; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Leigh Disease; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1992 |
[Neurologic complications during chemotherapy of children with acute lymphoid leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Diseases; Child; Female; Hemiplegia; Humans; Intracranial Embolism and Thrombosis; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1992 |
[Recent advances in oncology. Acute lymphoblastic leukemia in children].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Child, Preschool; Chromosome Deletion; Cytogenetics; Humans; Methotrexate; Philadelphia Chromosome; Ploidies; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Translocation, Genetic | 1991 |
CNS prophylaxis of childhood leukemia: what are the long-term neurological, neuropsychological, and behavioral effects?
Topics: Brain; Brain Damage, Chronic; Brain Neoplasms; Child; Child Behavior Disorders; Cranial Irradiation; Follow-Up Studies; Humans; Injections, Spinal; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Wechsler Scales | 1991 |
Methotrexate and childhood leukemia.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 1991 |
Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Coma; Cytarabine; Female; Humans; Injections, Spinal; Methotrexate; Neoplasm Recurrence, Local; Paralysis; Paraplegia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases | 1991 |
Central nervous system relapse prevention in 1165 standard-risk children with acute lymphoblastic leukemia in five BFM trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; Germany, West; Humans; Injections, Spinal; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Spinal Cord Neoplasms | 1990 |
Transient focal leukoencephalopathy following intraventricular methotrexate and cytarabine. A complication of the Ommaya reservoir: case report and review of the literature.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Cytarabine; Humans; Infusions, Parenteral; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
Therapy for childhood non-Hodgkin's lymphomas, nonlymphoblastic type. Review of recent studies and current recommendations.
Topics: Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Brain Neoplasms; Cell Differentiation; Child; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Daunorubicin; Doxorubicin; France; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survival Rate; United States; Vincristine | 1990 |
Late anaplastic gliomas in children previously treated for acute lymphoblastic leukemia.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Glioma; Humans; Infant; Methotrexate; Neoplasms, Radiation-Induced; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy | 1989 |
Neurotoxicity due to central nervous system therapy for childhood leukemia.
Topics: Central Nervous System; Child; Cytarabine; Humans; Meningeal Neoplasms; Methotrexate; Neurosecretory Systems; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
[Intensification of the initial treatment in acute lymphoblastic leukemias of middle and high risk in children].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Cytarabine; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors | 1989 |
Radiotherapy vs intrathecal chemotherapy for CNS prophylaxis in childhood ALL.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Combined Modality Therapy; Humans; Injections, Spinal; Methotrexate; Nervous System Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
328 trial(s) available for methotrexate and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
SWOG 1318: A Phase II Trial of Blinatumomab Followed by POMP Maintenance in Older Patients With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia.
Topics: Aged; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Humans; Lymphoma, B-Cell; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Hyper-CVAD and sequential blinatumomab for newly diagnosed Philadelphia chromosome-negative B-cell acute lymphocytic leukaemia: a single-arm, single-centre, phase 2 trial.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2022 |
Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.
Topics: Adult; Antibodies, Bispecific; Cardiovascular Diseases; Humans; Inotuzumab Ozogamicin; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Salvage Therapy | 2023 |
Chemotherapy intravenously in children with cancer at home, the nurse practitioner makes it possible!
Topics: Administration, Intravenous; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cytarabine; Female; Home Care Services; Humans; Male; Methotrexate; Netherlands; Nurse Practitioners; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life | 2019 |
Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Time; Treatment Outcome; Vincristine | 2020 |
Association of
Topics: Genotype; Malaysia; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Adolescent and young adult acute lymphoblastic leukemia. Final results of the phase II pediatric-like GIMEMA LAL-1308 trial.
Topics: Adolescent; Adult; Allografts; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Italy; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome; Vincristine; Young Adult | 2021 |
Adaptive functioning and academic achievement in survivors of childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group.
Topics: Academic Success; Adaptation, Psychological; Adolescent; Antineoplastic Agents; Cancer Survivors; Child; Child, Preschool; Dexamethasone; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome | 2021 |
Maintenance therapy and risk of osteonecrosis in children and young adults with acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; DNA Adducts; Erythrocytes; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Middle Aged; Osteonecrosis; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Thioguanine; Young Adult | 2021 |
Hepatic sinusoidal obstruction syndrome during maintenance therapy of childhood acute lymphoblastic leukemia is associated with continuous asparaginase therapy and mercaptopurine metabolites.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Drug Interactions; Female; Hepatic Veno-Occlusive Disease; Humans; Infant; Kaplan-Meier Estimate; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models | 2017 |
Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation
Topics: Adolescent; Adult; Aged; Antilymphocyte Serum; Double-Blind Method; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; HLA Antigens; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Tacrolimus; Young Adult | 2017 |
Effectiveness of antibacterial prophylaxis during induction chemotherapy in children with acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacteremia; Child; Child, Preschool; Doxorubicin; Female; Follow-Up Studies; Humans; Induction Chemotherapy; Infant; Male; Methotrexate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Rate; Vincristine; Young Adult | 2018 |
Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Infant; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2018 |
High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Risk Factors; Transplantation, Homologous; Treatment Outcome; Vincristine | 2013 |
Treatment for hepatitis C virus-induced portal hypertension in leukemic children.
Topics: Administration, Oral; Amlodipine; Antineoplastic Combined Chemotherapy Protocols; Blood Pressure; Calcium Channel Blockers; Child; Cohort Studies; Heart Rate; Hepatitis C; Humans; Hypertension, Portal; Male; Mercaptopurine; Methotrexate; Portal Pressure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2013 |
Incorporation of 6-thioguanine nucleotides into DNA during maintenance therapy of childhood acute lymphoblastic leukemia-the influence of thiopurine methyltransferase genotypes.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; DNA; Female; Genotype; Guanine Nucleotides; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides | 2013 |
Caregiving demands and well-being in parents of children treated with outpatient or inpatient methotrexate infusion: a report from the children's oncology group.
Topics: Adult; Antimetabolites, Antineoplastic; Caregivers; Child; Child, Preschool; Cost of Illness; Female; Health Services Accessibility; Humans; Infusions, Intravenous; Inpatients; Male; Methotrexate; Outpatients; Parents; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Socioeconomic Factors | 2014 |
Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Child; Child, Preschool; Enzyme Inhibitors; Female; Humans; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins | 2013 |
[Molecular genetic detection of minimal residual disease (MRD) in children with acute lymphoblastic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Genetic Markers; Humans; Mercaptopurine; Methotrexate; Neoplasm, Residual; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Vincristine | 2013 |
Prediction of outcome by early response in childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biopsy; Bone Marrow; Cell Lineage; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Patient Outcome Assessment; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Remission Induction; Risk Assessment; Vincristine | 2013 |
Disseminated lymphoblastic lymphoma in children and adolescents: results of the COG A5971 trial: a report from the Children's Oncology Group.
Topics: Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Cyclophosphamide; Disease-Free Survival; Female; Humans; Injections, Spinal; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Extended duration of prehydration does not prevent nephrotoxicity or delayed drug elimination in high-dose methotrexate infusions: a prospectively randomized cross-over study.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Combined Modality Therapy; Cross-Over Studies; Female; Fluid Therapy; Follow-Up Studies; Humans; Infant; Infusions, Intravenous; Kidney Diseases; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Time Factors; Tissue Distribution; Young Adult | 2014 |
The circadian schedule for childhood acute lymphoblastic leukemia maintenance therapy does not influence event-free survival in the NOPHO ALL92 protocol.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Circadian Rhythm; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Survival Rate | 2014 |
The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial.
Topics: Adolescent; Child; Child, Preschool; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sirolimus; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous; Whole-Body Irradiation; Young Adult | 2014 |
Dose intensification of methotrexate and cytarabine during intensified continuation chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: POG 9406: a report from the Children's Oncology Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Factors; Survival Rate; Teniposide | 2014 |
Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukaemia (UKALL 2003): a randomised controlled trial.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Consolidation Chemotherapy; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Hypersensitivity; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Mucositis; Neoplasm, Residual; Pancreatitis; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Assessment; Stomatitis; Survival Rate; Vincristine | 2014 |
Safety and clinical activity of 5-aza-2'-deoxycytidine (decitabine) with or without Hyper-CVAD in relapsed/refractory acute lymphocytic leukaemia.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Decitabine; Dexamethasone; DNA Methylation; DNA, Neoplasm; Doxorubicin; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Hyperglycemia; Infusions, Intravenous; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Salvage Therapy; Vincristine; Young Adult | 2014 |
Long-term outcome of a pediatric-inspired regimen used for adults aged 18-50 years with newly diagnosed acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Doxorubicin; Drug Administration Schedule; Female; Humans; Karyotyping; Male; Methotrexate; Middle Aged; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Treatment Outcome; Vincristine | 2015 |
Postinduction minimal residual disease monitoring by polymerase chain reaction in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Italy; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; Remission Induction; Steroids; Treatment Outcome | 2014 |
Phase II study of methotrexate, vincristine, pegylated-asparaginase, and dexamethasone (MOpAD) in patients with relapsed/refractory acute lymphoblastic leukemia.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Bilirubin; Dexamethasone; Female; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Recurrence; Rituximab; Survival Analysis; T-Lymphocytes; Transaminases; Treatment Outcome; Vincristine | 2015 |
Long-term results of the AIEOP LNH-97 protocol for childhood lymphoblastic lymphoma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers, Tumor; Child; Cyclophosphamide; Disease Progression; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2015 |
Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Risk Factors; United States; Vincristine | 2015 |
Therapeutic value of black seed oil in methotrexate hepatotoxicity in Egyptian children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cuminum; Female; Humans; Infant; Leucovorin; Liver; Male; Methotrexate; Plant Oils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Seeds | 2015 |
Long-term follow-up of imatinib plus combination chemotherapy in patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Survival Analysis; Transplantation, Homologous; Vincristine | 2015 |
Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm, Residual; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Treatment Outcome; Vincristine; Young Adult | 2015 |
ω-3 fatty acids as an adjuvant therapy ameliorates methotrexate-induced hepatotoxicity in children and adolescents with acute lymphoblastic leukemia: A randomized placebo-controlled study.
Topics: Adolescent; Antioxidants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Double-Blind Method; Fatty Acids, Omega-3; Female; Glutathione Peroxidase; Humans; Liver; Male; Malondialdehyde; Methotrexate; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Superoxide Dismutase | 2016 |
Efficacy and toxicity of a paediatric protocol in teenagers and young adults with Philadelphia chromosome negative acute lymphoblastic leukaemia: results from UKALL 2003.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Daunorubicin; Dexamethasone; Female; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Assessment; Survival Analysis; Treatment Outcome; Vincristine; Young Adult | 2016 |
Anxiety, pain, and nausea during the treatment of standard-risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Anxiety; Asparaginase; Child; Child, Preschool; Consolidation Chemotherapy; Cyclophosphamide; Cytarabine; Dexamethasone; Female; Humans; Induction Chemotherapy; Longitudinal Studies; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Nausea; Pain; Parents; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Surveys and Questionnaires; Vincristine | 2016 |
Dexamethasone vs prednisone in induction treatment of pediatric ALL: results of the randomized trial AIEOP-BFM ALL 2000.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Dexamethasone; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Kaplan-Meier Estimate; Male; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Remission Induction; Treatment Outcome | 2016 |
Influence of Folate-Related Gene Polymorphisms on High-Dose Methotrexate-Related Toxicity and Prognosis in Turkish Children with Acute Lymphoblastic Leukemia.
Topics: Adolescent; Child; Child, Preschool; Disease-Free Survival; Female; Ferredoxin-NADP Reductase; Humans; Infant; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate | 2017 |
Mexican Childhood Acute Lymphoblastic Leukemia: A Pilot Study of the MDR1 and MTHFR Gene Polymorphisms and Their Associations with Clinical Outcomes.
Topics: Adolescent; ATP Binding Cassette Transporter, Subfamily B; Child; Child, Preschool; Female; Homozygote; Humans; Leukopenia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Mucositis; Pilot Projects; Polymorphism, Restriction Fragment Length; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 2016 |
High hyperdiploid acute lymphoblastic leukemia (ALL)-A 25-year population-based survey of the Austrian ALL-BFM (Berlin-Frankfurt-Münster) Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chromosomes, Human, Pair 17; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Male; Mercaptopurine; Methotrexate; Mosaicism; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Time Factors; Trisomy; Vincristine | 2017 |
A thymidylate synthase polymorphism is associated with increased risk for bone toxicity among children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Asparaginase; Child; Child, Preschool; Female; Fractures, Bone; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Osteonecrosis; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase | 2017 |
Neurocognitive outcomes among children who experienced seizures during treatment for acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cognition Disorders; Cytarabine; Dexamethasone; Female; Humans; Hydrocortisone; Incidence; Leukoencephalopathies; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Seizures; Vincristine | 2017 |
Minimal residual disease is an important predictive factor of outcome in children with relapsed 'high-risk' acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Infant; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Prognosis; Prospective Studies; Recurrence; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Survival Analysis; Treatment Outcome; Vincristine | 2008 |
Intensive chemotherapy improved treatment outcome for Chinese children and adolescents with lymphoblastic lymphoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Humans; Injections, Spinal; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2008 |
Relationship between oral mucositis and high-dose methotrexate therapy in pediatric acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Area Under Curve; Cell Survival; Cells, Cultured; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infant; Keratinocytes; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis | 2008 |
[Investigation on individualized adjustment of target range of high-dose methotrexate].
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
Pharmacokinetics of high-dose methotrexate in infants treated for acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2009 |
Treating childhood acute lymphoblastic leukemia without cranial irradiation.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Daunorubicin; Dexamethasone; Hematopoietic Stem Cell Transplantation; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Secondary Prevention; Survival Analysis; Treatment Outcome; Vincristine | 2009 |
DV-ICE, intensive induction and early transplantation for adult patients with acute lymphoblastic leukemia: a phase II study.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cytarabine; Dexamethasone; Disease-Free Survival; Early Termination of Clinical Trials; Etoposide; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Hydrocortisone; Idarubicin; Kaplan-Meier Estimate; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Treatment Failure; Vincristine; Young Adult | 2009 |
Response to glucocorticoids and toxicity in childhood acute lymphoblastic leukemia: role of polymorphisms of genes involved in glucocorticoid response.
Topics: Adolescent; Child; Child, Preschool; Dexamethasone; Female; Glucocorticoids; Glutathione Transferase; Humans; Infant; Infections; Male; Methotrexate; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone | 2009 |
Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.
Topics: Administration, Oral; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Survival Analysis; Treatment Outcome; Vincristine | 2009 |
A phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft versus host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL).
Topics: Adolescent; Child; Child, Preschool; Epidemiologic Methods; Female; Graft Survival; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Sirolimus; Tacrolimus; Treatment Outcome; Young Adult | 2009 |
Comparison of neurocognitive functioning in children previously randomly assigned to intrathecal methotrexate compared with triple intrathecal therapy for the treatment of childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Attention; Child; Child, Preschool; Cognition; Cross-Sectional Studies; Cytarabine; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Intelligence Tests; Linear Models; Male; Memory; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Time Factors; Treatment Outcome; United States | 2009 |
Population pharmacokinetic study of methotrexate in children with acute lymphoblastic leukemia.
Topics: Age Factors; Antimetabolites, Antineoplastic; Asian People; Bayes Theorem; Body Surface Area; Child; Child, Preschool; China; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Methotrexate; Models, Biological; Nonlinear Dynamics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors; Tissue Distribution | 2010 |
Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Hepatic Veno-Occlusive Disease; Humans; Hypertension, Portal; Infant; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 2010 |
Benefits of the intermittent use of 6-mercaptopurine and methotrexate in maintenance treatment for low-risk acute lymphoblastic leukemia in children: randomized trial from the Brazilian Childhood Cooperative Group--protocol ALL-99.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brazil; Child; Child, Preschool; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors; Survival Rate; Treatment Outcome | 2010 |
The association of reduced folate carrier 80G>A polymorphism to outcome in childhood acute lymphoblastic leukemia interacts with chromosome 21 copy number.
Topics: Adolescent; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Child; Child, Preschool; Chromosomes, Human, Pair 21; Female; Humans; Infant; Male; Membrane Transport Proteins; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Remission Induction; Retrospective Studies | 2010 |
Simultaneous detection of MDR1 and WT1 gene expression to predict the prognosis of adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers, Tumor; Bone Marrow; Cohort Studies; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Leukemic; Genes, Wilms Tumor; Humans; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; RNA, Messenger; RNA, Neoplasm; Vincristine; WT1 Proteins; Young Adult | 2010 |
Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Dexamethasone; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Assessment; Survival Analysis; Treatment Outcome; Vincristine | 2010 |
Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial.
Topics: Adolescent; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Etoposide; Female; Humans; Idarubicin; Infant; Kaplan-Meier Estimate; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk Assessment; Treatment Outcome; United Kingdom; Vidarabine; Vincristine | 2010 |
Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.
Topics: Cell Division; Cohort Studies; Computational Biology; Computer Simulation; Drug Resistance, Neoplasm; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Polyglutamic Acid; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
The utility of performing the initial lumbar puncture on day 8 in remission induction therapy for childhood acute lymphoblastic leukemia: TCCSG L99-15 study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Cytarabine; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Neoplasm Recurrence, Local; Netherlands; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prospective Studies; Remission Induction; Spinal Puncture; Survival Rate; Time Factors; Treatment Outcome | 2012 |
[Long-term observations of children with acute lymphoblastic leukemia and high leukocytosis treated according to modified "New York" protocols (1987-2003)].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Comorbidity; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Leukocytosis; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Thioguanine; Vincristine | 2010 |
[Clinical tolerance of high-dose methotrexate used in consolidation therapy in children with acute lymphoblastic leukemia].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Incidence; Infant; Infections; Male; Methotrexate; Nausea; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vomiting | 2010 |
Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: results of Children's Oncology Group trial P9906.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Thioguanine; Treatment Outcome; Vincristine | 2011 |
Fludarabine and pharmacokinetic-targeted busulfan before allografting for adults with acute lymphoid leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Disease-Free Survival; Female; Follow-Up Studies; Graft Survival; Graft vs Host Disease; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous; Vidarabine | 2011 |
The role of HLA--G 14-bp polymorphism in allo-HSCT after short-term course MTX for GvHD prophylaxis.
Topics: Adolescent; Adult; Child; Disease-Free Survival; Female; Follow-Up Studies; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; HLA-G Antigens; Humans; Immunosuppressive Agents; INDEL Mutation; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate; Time Factors; Transplantation, Homologous | 2012 |
High dose methotrexate treatment in children with acute lymphoblastic leukaemia may be optimised by a weight-based dose calculation.
Topics: Age Factors; Antimetabolites, Antineoplastic; Body Weight; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Models, Biological; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors | 2011 |
Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child, Preschool; Drug Administration Schedule; Humans; Infant; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines | 2011 |
Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404).
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Mucositis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Young Adult | 2011 |
Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Topics: Algorithms; Antineoplastic Agents; Child; Child, Preschool; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Infant; Injections, Intravenous; Male; Medical Oncology; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Societies, Medical | 2011 |
Study of the pharmacokinetic and pharmacogenetic contribution to the toxicity of high-dose methotrexate in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Feasibility Studies; Female; Fever; Humans; Infant; Male; Mercaptopurine; Methotrexate; Mucositis; Pancreatitis; Pilot Projects; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
Pneumocystis jiroveci pneumonia prophylaxis during maintenance therapy influences methotrexate/6-mercaptopurine dosing but not event-free survival for childhood acute lymphoblastic leukemia.
Topics: Administration, Oral; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Male; Mercaptopurine; Methotrexate; Pneumocystis carinii; Pneumonia, Pneumocystis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Trimethoprim, Sulfamethoxazole Drug Combination | 2012 |
[Efficacy, side effects and blood concentration monitoring of high-dose methotrexate in treatment of 180 children with acute lymphoblastic leukemia].
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
Proinflammatory cytokines during the initial phase of oral mucositis in patients with acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cytokines; Humans; Inflammation Mediators; Interleukin-1; Interleukin-6; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Stomatitis; Time Factors; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI.
Topics: Antineoplastic Agents; Central Nervous System Neoplasms; Child, Preschool; Female; Humans; Infant; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
Palonosetron for the prevention of nausea and vomiting in children with acute lymphoblastic leukemia treated with high dose methotrexate.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Denmark; Female; Humans; Isoquinolines; Male; Methotrexate; Nausea; Palonosetron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinuclidines; Serotonin Antagonists; Time Factors; Vomiting | 2012 |
Asparaginase-associated myelosuppression and effects on dosing of other chemotherapeutic agents in childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Female; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Dose intensification of daunorubicin and cytarabine during treatment of adult acute lymphoblastic leukemia: results of Cancer and Leukemia Group B Study 19802.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Male; Methotrexate; Middle Aged; Neoplasm Metastasis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Young Adult | 2013 |
Treatment of young patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia using increased dose of imatinib and deintensified chemotherapy before allogeneic stem cell transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Combined Modality Therapy; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Etoposide; Female; Humans; Imatinib Mesylate; Male; Mercaptopurine; Methotrexate; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pyrimidines; Stem Cell Transplantation; Transplantation, Homologous; Treatment Outcome; Vincristine; Young Adult | 2012 |
Effect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cohort Studies; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Incidence; Infant; Male; Methotrexate; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Sex Distribution; Sex Factors; Survival Rate; Treatment Outcome; Vincristine; Young Adult | 2012 |
Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Attention; Child; Child, Preschool; Cognition; Cranial Irradiation; Cytarabine; Dexamethasone; Drug Administration Schedule; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Intelligence; Intelligence Tests; Logistic Models; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Patient Selection; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Sex Factors; Time Factors; Treatment Outcome; Vincristine | 2012 |
Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Homocysteine; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Comparison of pharmacokinetics and toxicity after high-dose methotrexate treatments in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Area Under Curve; Cerebrospinal Fluid; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Infant; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Genome-wide study of methotrexate clearance replicates SLCO1B1.
Topics: Adolescent; Alleles; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Humans; Infant; Infusions, Intravenous; Leucovorin; Linear Models; Liver-Specific Organic Anion Transporter 1; Male; Metabolic Clearance Rate; Methotrexate; Multivariate Analysis; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Disease-Free Survival; Female; Humans; Infant; Ireland; Male; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk Factors; Treatment Outcome; United Kingdom; Vincristine | 2013 |
De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Leukemia-Lymphoma, Adult T-Cell; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines | 2002 |
Central nervous system prophylaxis with high-dose methotrexate does not give rise to significant electroencephalographic changes in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain; Central Nervous System Neoplasms; Child; Child, Preschool; Electroencephalography; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2002 |
A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia.
Topics: Aneuploidy; Antimetabolites, Antineoplastic; B-Lymphocytes; Bone Marrow; Burkitt Lymphoma; Carrier Proteins; Cell Lineage; Child; Female; gamma-Glutamyl Hydrolase; Humans; Infusions, Intravenous; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Models, Biological; Neoplasm Proteins; Neoplastic Stem Cells; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; T-Lymphocytes | 2002 |
Treatment outcome of adolescents with acute lymphoblastic leukemia.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Risk Factors; Survival Analysis; Survival Rate; Treatment Outcome | 2002 |
[Results of the treatment of childhood acute lymphoblastic leukemia according to the Berlin-Moscow-91 protocol in 1991-2000].
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Data Interpretation, Statistical; Daunorubicin; Dexamethasone; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Moscow; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Russia; Survival Analysis; Time Factors; Vincristine | 2002 |
[Treatment of acute lymphoblastic leukemia in children according to the ALL-BFM-90m protocol in the Russian Federation and the Republic of Belarus].
Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chi-Square Distribution; Child; Child, Preschool; Data Interpretation, Statistical; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Republic of Belarus; Risk Factors; Russia; Sex Factors; Survival Analysis; Time Factors | 2002 |
Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia: significance of low leukocyte counts with blasts or traumatic lumbar puncture.
Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cerebrospinal Fluid; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Female; Humans; Infant; Infant, Newborn; Injections, Spinal; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Risk Factors; Spinal Puncture; Treatment Outcome | 2003 |
Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Blood Cell Count; Child; Child, Preschool; Dexamethasone; Drug Administration Schedule; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Karyotyping; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone | 2003 |
Effects of sodium in hydration solution on plasma methotrexate concentrations following high-dose methotrexate in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Female; Fluid Therapy; Humans; Infusions, Intravenous; Liver; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sodium | 2003 |
Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Female; Humans; Infant; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Sex Factors; Thioguanine | 2003 |
The dose related effect of steroids on blast reduction rate and event free survival in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Male; Methotrexate; Methylprednisolone; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Retrospective Studies; Survival Analysis; Treatment Outcome; Vincristine | 2003 |
Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Bone Marrow Cells; Child; Chromatography, High Pressure Liquid; Humans; Hypoxanthine; Injections, Intravenous; Leukocyte Count; Mercaptopurine; Methotrexate; Nucleosides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine; Xanthines | 2003 |
Long-term survival in acute lymphoblastic leukaemia in adults treated according to the LALA 87 protocol.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cyclophosphamide; Daunorubicin; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Treatment Outcome; Vincristine | 2003 |
[The assessment of plasma levels of insulin-like growth factor (IGF-I) and binding protein (IGFBP-3) during the maintenance therapy and after remissionof acute lymphoblastic leukemia (ALL)].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Height; Body Mass Index; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Puberty; Radiotherapy, Adjuvant; Remission Induction; Vincristine | 2003 |
[Improved results in children with acute lymphoblastic leukemia treated with the ALL-BFM 90 protocol in the Czech Republic].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Vincristine | 2003 |
A randomized trial of induction therapy (daunorubicin, vincristine, prednisone versus daunorubicin, vincristine, prednisone, cytarabine and 6-thioguanine) in adult acute lymphoblastic leukemia with long-term follow-up: an Eastern Cooperative Oncology Grou
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Life Tables; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Remission Induction; Survival Analysis; Thioguanine; Treatment Outcome; Vincristine | 2003 |
Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172).
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Humans; Infant; Leukocyte Count; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2004 |
Does vitamin A prevent high-dose-methotrexate-induced D-xylose malabsorption in children with cancer?
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Lymphoma, Non-Hodgkin; Malabsorption Syndromes; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Protective Agents; Retinol-Binding Proteins; Vitamin A; Xylose | 2004 |
Correlation of cerebrospinal fluid beta-glucuronidase activity with plasma methotrexate concentrations in leukemic children receiving high-dose methotrexate.
Topics: Biomarkers; Child; Child, Preschool; Clinical Enzyme Tests; Female; Glucuronidase; Humans; Infant; Inflammation; Linear Models; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
Skeletal morbidity in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Bone Density; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Female; Follow-Up Studies; Fractures, Bone; Humans; Infant; Lumbar Vertebrae; Male; Methotrexate; Morbidity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors | 2004 |
High-dose methotrexate therapy of childhood acute lymphoblastic leukemia: lack of relation between serum methotrexate concentration and creatinine clearance.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Chile; Creatine; Disease-Free Survival; Drug Monitoring; Female; Hematologic Diseases; Humans; Infant; Leucovorin; Male; Metabolic Clearance Rate; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis | 2004 |
[Effects of different first dose calcium tetrahydro-folate on toxicity and side effects of large dose methotrexate treated standard risk group children with acute lymphoblastic leukemia].
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors; Tetrahydrofolates; Treatment Outcome | 2004 |
Toxicity and efficacy of intensive chemotherapy for children with acute lymphoblastic leukemia (ALL) after first bone marrow or extramedullary relapse.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacteremia; Bone Marrow Neoplasms; Child; Child, Preschool; Cytarabine; Dexamethasone; Etoposide; Female; Flow Cytometry; Humans; Idarubicin; Ifosfamide; Infant; Infusions, Intravenous; Leucovorin; Male; Mesna; Methotrexate; Mouth Mucosa; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Stomatitis; Thioguanine; Treatment Outcome; Vincristine | 2004 |
Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Antimetabolites, Antineoplastic; B-Lymphocytes; Child; Child, Preschool; Female; Follow-Up Studies; Hematopoietic Stem Cells; Humans; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Treatment Outcome | 2005 |
Value of intravenous 6-mercaptopurine during continuation treatment in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma: final results of a randomized phase III trial (58881) of the EORTC CLG.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Evaluation Studies as Topic; Female; Humans; Infant; Injections, Intravenous; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Patient Compliance; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Treatment Outcome | 2005 |
The effects of ondansetron and granisetron on electrocardiography in children receiving chemotherapy for acute leukemia.
Topics: Adolescent; Antiemetics; Antimetabolites, Antineoplastic; Child; Child, Preschool; Electrocardiography; Female; Granisetron; Heart Rate; Humans; Male; Methotrexate; Nausea; Ondansetron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serotonin Antagonists; Vomiting | 2005 |
Attention and information processing in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only.
Topics: Antineoplastic Agents; Attention; Central Nervous System Neoplasms; Child; Cognition Disorders; Contraindications; Female; Humans; Injections, Spinal; Male; Mental Processes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychological Tests; Radiotherapy; Survivors | 2005 |
Capacity buffer of the saliva in children and adolescents with cancer: Variations induced by the administration of metotrexate or cyclophosphamide.
Topics: Acid-Base Equilibrium; Adolescent; Antineoplastic Agents, Alkylating; Buffers; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Hydrogen-Ion Concentration; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva | 2005 |
Transplant-finalized salvage of adult acute lymphoblastic leukemia: results of a mitoxantrone- and methotrexate-based regimen in 36 patients.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Treatment Outcome; Vincristine | 2005 |
Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Factors; Salvage Therapy; Survival Rate; Thioguanine; Time Factors; Treatment Outcome | 2005 |
Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cyclophosphamide; Cytarabine; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Hydrocortisone; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Survival Rate; Vincristine | 2005 |
MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95.
Topics: Adolescent; Age Factors; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Homozygote; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Sex Factors; Treatment Outcome | 2006 |
Population pharmacokinetic study of methotrexate in patients with lymphoid malignancy.
Topics: Adult; Age Factors; Aged; Algorithms; Antimetabolites, Antineoplastic; Bayes Theorem; Burkitt Lymphoma; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Lymphoma, Large B-Cell, Diffuse; Male; Metabolic Clearance Rate; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 2006 |
Role of treatment intensification in infants with acute lymphoblastic leukemia: results of two consecutive AIEOP studies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Hematopoietic Stem Cell Transplantation; Humans; Infant, Newborn; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine | 2006 |
Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993.
Topics: Adolescent; Adult; Asparaginase; Central Nervous System Neoplasms; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate | 2006 |
Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemi
Topics: Age Factors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Female; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Retrospective Studies; Risk Factors; Sex Factors; T-Lymphocytes; Testicular Neoplasms; Time Factors | 2006 |
Brief report: effect of intravenous methotrexate dose and infusion rate on neuropsychological function one year after diagnosis of acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Longitudinal Studies; Male; Memory Disorders; Memory, Short-Term; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Verbal Learning; Vocabulary; Wechsler Scales | 2007 |
[Assessment of elimination and tolerance of high dose of methotrexate (3 g/m2) in children with standard-risk acute lymphoblastic leukemia].
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Infant; Kidney; Liver; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2006 |
Body mass index does not influence pharmacokinetics or outcome of treatment in children with acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Remission Induction; Retrospective Studies; Teniposide | 2006 |
Results of the PETHEMA ALL-96 trial in elderly patients with Philadelphia chromosome-negative acute lymphoblastic leukemia.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Comorbidity; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Middle Aged; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Severity of Illness Index; Survival Analysis; Teniposide; Treatment Outcome; Vincristine | 2007 |
Population pharmacokinetics of high-dose methotrexate in children with acute lymphoblastic leukaemia.
Topics: Adolescent; Age Factors; Alanine Transaminase; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotransferases; Bayes Theorem; Body Weight; Child; Child, Preschool; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Infant; Infusions, Intravenous; Leucovorin; Male; Metabolic Clearance Rate; Methotrexate; Models, Biological; Monte Carlo Method; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Vitamin B Complex | 2006 |
High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations.
Topics: Adolescent; Antimetabolites, Antineoplastic; Area Under Curve; Child; Dose-Response Relationship, Drug; Female; Gene Frequency; Germany; Half-Life; Haplotypes; Humans; Infusions, Intravenous; Male; Membrane Transport Proteins; Metabolic Clearance Rate; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Multivariate Analysis; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Sex Factors | 2006 |
Methotrexate pharmacokinetics in infants with acute lymphoblastic leukemia.
Topics: Age Factors; Drug Administration Schedule; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Very high-dose methotrexate (33.6 g/m(2)) as central nervous system preventive therapy for childhood acute lymphoblastic leukemia: results of National Cancer Institute/Children's Cancer Group trials CCG-191P, CCG-134P and CCG-144P.
Topics: Adolescent; Adult; Central Nervous System Neoplasms; Child; Child, Preschool; Cognition; Female; Humans; Infant; Male; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Treatment Outcome | 2006 |
Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.
Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Brain Diseases, Metabolic; Child; Child, Preschool; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Neurotoxins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Assessment | 2007 |
Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Encephalitis; Female; Humans; Injections, Spinal; Leukemic Infiltration; Liposomes; Male; Meninges; Meningitis; Methotrexate; Middle Aged; Papilledema; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Vincristine | 2007 |
Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial.
Topics: Adolescent; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dexamethasone; Disease-Free Survival; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2007 |
Intravenous busulfan and melphalan, tacrolimus, and short-course methotrexate followed by unmodified HLA-matched related or unrelated hematopoietic stem cell transplantation for the treatment of advanced hematologic malignancies.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; Child, Preschool; Female; Hematopoietic Stem Cell Transplantation; Histocompatibility Testing; Humans; Immunosuppressive Agents; Infant; Leukemia, Myeloid, Acute; Male; Melphalan; Methotrexate; Middle Aged; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Survival Analysis; Tacrolimus; Transplantation Conditioning | 2007 |
[Auditory evoked potentials in patients after acute children's lymphoblastic leukemia treatment].
Topics: Acoustic Stimulation; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Evoked Potentials, Auditory, Brain Stem; Female; Hearing Disorders; Hearing Tests; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Reaction Time; Thioguanine; Vincristine | 2006 |
[Peripheral blood stem cell transplantation for 53 patients with malignant hematologic diseases].
Topics: Adolescent; Adult; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclosporine; Disease-Free Survival; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation Conditioning; Transplantation, Homologous; Young Adult | 2007 |
Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Cell Lineage; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Infusions, Intravenous; Injections, Intramuscular; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine | 2007 |
[Modified BFM-90 regimen greatly improves treatment outcomes of chinese childhood and adolescent lymphoblastic lymphoma].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asian People; Asparaginase; Child; Child, Preschool; China; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine | 2007 |
Evaluation of renal function in Turkish children receiving BFM-95 therapy for acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Kidney Diseases; Kidney Function Tests; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Turkey; Vincristine | 2007 |
Phase II study of chemotherapy and stem cell transplantation for adult acute lymphoblastic leukemia or lymphoblastic lymphoma: Japan Clinical Oncology Group Study 9004.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Combined Modality Therapy; Cytarabine; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stem Cell Transplantation; Transplantation, Autologous | 2007 |
A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Follow-Up Studies; Humans; Infant; Infant, Newborn; Leukemia, Myeloid, Acute; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone | 2007 |
Phase 2B trial of aminopterin in multiagent therapy for children with newly diagnosed acute lymphoblastic leukemia.
Topics: Adolescent; Aminopterin; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Diseases; Child; Child, Preschool; Drug Overdose; Erythrocytes; Female; Fever; Folic Acid Antagonists; Gastrointestinal Diseases; Humans; Leucovorin; Male; Methotrexate; Neurotoxicity Syndromes; Pilot Projects; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome | 2008 |
[The results of a multicenter trial of acute lymphoblastic leukemia treatment on ALL-MB 91/ALL-BFM 90m in children: analysis of efficacy and toxicity].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome; Vincristine | 2007 |
Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01.
Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Central Nervous System Neoplasms; Child; Child, Preschool; Cranial Irradiation; Cytarabine; Female; Glucocorticoids; Humans; Hydrocortisone; Infant; Injections, Spinal; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Kaplan-Meier Estimate; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2008 |
Outcome after relapse among children with standard-risk acute lymphoblastic leukemia: Children's Oncology Group study CCG-1952.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Female; Humans; Hydrocortisone; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Stem Cell Transplantation; Survival Analysis; Thioguanine; Treatment Outcome | 2007 |
Long-term results of the AIEOP-ALL-95 Trial for Childhood Acute Lymphoblastic Leukemia: insight on the prognostic value of DNA index in the framework of Berlin-Frankfurt-Muenster based chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chi-Square Distribution; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; DNA, Neoplasm; Female; Humans; Infant; Italy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Survival Rate; Treatment Outcome; Vincristine | 2008 |
Results of the first randomized multicentre trial on childhood acute lymphoblastic leukaemia in Russia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Feasibility Studies; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Palliative Care; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Russia; Treatment Outcome; Vincristine | 2008 |
Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the Programa Español de Tratamiento en Hematología pediatric-based protocol ALL-96.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Hematologic Diseases; Humans; Hydrocortisone; Infant; Infections; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Treatment Outcome; Vincristine | 2008 |
Aggressive lymphomas with renal involvement: a study of 48 patients treated with the LNH-84 and LNH-87 regimens. Groupe d'Etude des Lymphomes de l'Adulte.
Topics: Actuarial Analysis; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chi-Square Distribution; Creatinine; Cyclophosphamide; Doxorubicin; Female; Humans; Kidney; Kidney Neoplasms; L-Lactate Dehydrogenase; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, Non-Hodgkin; Male; Methotrexate; Methylprednisolone; Middle Aged; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Proportional Hazards Models; Remission Induction; Survival Analysis; Survival Rate; Treatment Outcome; Vindesine | 1994 |
Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia.
Topics: Burkitt Lymphoma; Child; Hematopoietic Stem Cells; Humans; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Peptide Synthases; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1994 |
Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Ploidies; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1994 |
Changes of cerebral biopterin and biogenic amine metabolism in leukemic children receiving 5 g/m2 intravenous methotrexate.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biogenic Amines; Biopterins; Brain Chemistry; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cytarabine; Dihydropteridine Reductase; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Nerve Tissue Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 1995 |
Concomitant granulocyte colony-stimulating factor and induction chemoradiotherapy in adult acute lymphoblastic leukemia: a randomized phase III trial.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Disease-Free Survival; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Immunologic Factors; Infection Control; Male; Mercaptopurine; Methotrexate; Middle Aged; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Recombinant Proteins; Remission Induction; Survival Analysis; Treatment Outcome | 1995 |
Short-term weekly chemotherapy followed by high-dose therapy with autologous bone marrow transplantation for lymphoblastic and Burkitt's lymphomas in adult patients.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Transplantation; Burkitt Lymphoma; Carmustine; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Transplantation, Autologous; Vincristine | 1995 |
L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Synergism; Etoposide; Humans; Infant; Karyotyping; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone | 1995 |
Extended intrathecal methotrexate may replace cranial irradiation for prevention of CNS relapse in children with intermediate-risk acute lymphoblastic leukemia treated with Berlin-Frankfurt-Münster-based intensive chemotherapy. The Associazione Italiana d
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Regression Analysis; Remission Induction; Survival Analysis; Vincristine | 1995 |
Cognitive sequelae of treatment in childhood acute lymphoblastic leukemia: cranial radiation requires an accomplice.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Humans; Injections, Intravenous; Injections, Spinal; Intelligence; Intelligence Tests; Male; Memory Disorders; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Sex Factors | 1995 |
Outcome of treatment in adult acute lymphoblastic leukaemia in an Asian population: comparison with previous multicentre German study.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asia; Asparaginase; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Ethnicity; Female; Follow-Up Studies; Germany; Humans; Malaysia; Male; Methotrexate; Methylprednisolone; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Probability; Racial Groups; Survival Rate; Time Factors; Treatment Outcome; Vincristine | 1995 |
[Extramedullary relapse in childhood acute lymphoblastic leukemia: experience at the Kyushu Yamaguchi Children's Cancer Study Group].
Topics: Adolescent; Child; Child, Preschool; Cytarabine; Female; Humans; Infant; Male; Methotrexate; Ovarian Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Testicular Neoplasms | 1995 |
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Administration Schedule; Female; Humans; Immunophenotyping; Life Tables; Male; Mercaptopurine; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Risk Factors; Survival Analysis; Thioguanine; Treatment Outcome; Vincristine | 1995 |
Repetitive low dose oral methotrexate and intravenous mercaptopurine treatment for patients with lower risk B-lineage acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Central Nervous System Neoplasms; Child; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Injections, Intramuscular; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine | 1995 |
Comparison of treatment regimens for pediatric lymphoblastic non-Hodgkin's lymphoma: a Childrens Cancer Group study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cause of Death; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Thioguanine; Treatment Failure; Vincristine | 1995 |
Aminophylline for methotrexate-induced neurotoxicity.
Topics: Adenosine; Adolescent; Aminophylline; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infusions, Parenteral; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1995 |
Intensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X. Medical Research Council Working Party on Childhood Leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brain; Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Infant; Injections, Spinal; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Sex Factors; Survival Rate; Treatment Outcome; United Kingdom | 1995 |
Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Münster Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Clinical Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Etoposide; Follow-Up Studies; Humans; Ifosfamide; Infant; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Time Factors | 1995 |
Neuropsychological effects of cranial irradiation in young children with acute lymphoblastic leukemia 9 months after diagnosis. The Children's Cancer Group.
Topics: Adolescent; Brain; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance | 1995 |
Late intensification therapy in adult acute lymphoid leukemia: long-term follow-up of the Southeastern Cancer Study Group experience.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Life Tables; Male; Methotrexate; Middle Aged; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Remission Induction; Salvage Therapy; Survival Analysis; Treatment Outcome; United States; Vincristine | 1994 |
High-dose Ara-C for remission induction and consolidation of previously untreated adults with ALL or lymphoblastic lymphoma.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cytarabine; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Time Factors; Vincristine | 1995 |
Prolonged intrathecal chemotherapy replacing cranial irradiation in high-risk acute lymphatic leukaemia: long-term follow up with cerebral computed tomography scans and endocrinological studies.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Cranial Irradiation; Cytarabine; Disease-Free Survival; Female; Follow-Up Studies; Growth; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Pituitary Hormones, Anterior; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thyroid Hormones; Tomography, X-Ray Computed | 1995 |
Cerebrospinal fluid drug levels of leukemic children receiving intravenous 5 g/m2 methotrexate.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Child; Child, Preschool; Cytarabine; Female; Follow-Up Studies; Humans; Infant; Infusions, Intravenous; Leucovorin; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors | 1994 |
Adult acute lymphoblastic leukemia: results of an aggressive regimen in India.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Administration Schedule; Female; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine | 1994 |
[Clinical trial of protocol-AL851 for children with high-risk acute lymphoblastic leukemia. Kyushu Yamaguchi Children's Cancer Study Group (KYCCSG)].
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk; Survival Rate | 1994 |
Improvement in treatment of childhood acute lymphoblastic leukemia: a 10-year study by the Children's Cancer and Leukemia Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Japan; Life Tables; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate | 1994 |
Patient characteristics associated with high-risk methotrexate concentrations and toxicity.
Topics: Child; Child, Preschool; Female; Fluid Therapy; Humans; Hydrogen-Ion Concentration; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Urine; Vomiting | 1994 |
Comparison of two schedules of intermediate-dose methotrexate and cytarabine consolidation therapy for childhood B-precursor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Female; Humans; Infant; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; United States | 1994 |
[l-folinic acid versus racemic folinic acid in the treatment of leukemia in children with high dose of methotrexate].
Topics: Adolescent; Antidotes; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stereoisomerism | 1993 |
Importance of effective central nervous system therapy in isolated bone marrow relapse of childhood acute lymphoblastic leukemia. BFM (Berlin-Frankfurt-Münster) Relapse Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Rate | 1994 |
Results of Medical Research Council trial UKALL IX in acute lymphoblastic leukaemia in adults: report from the Medical Research Council Working Party on Adult Leukaemia.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Daunorubicin; Female; Follow-Up Studies; Humans; Leucovorin; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Sex Factors; Vincristine | 1993 |
Plasma and urine levels of methotrexate and 7-hydroxymethotrexate in children with ALL during maintenance therapy with weekly oral methotrexate.
Topics: Administration, Oral; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Humans; Lymphoma, Non-Hodgkin; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Regression Analysis; Remission Induction | 1994 |
Cyclosporine combined with methylprednisolone or methotrexate in prophylaxis of moderate to severe acute graft-versus-host disease.
Topics: Acute Disease; Adolescent; Adult; Bone Marrow Transplantation; Cyclosporine; Drug Therapy, Combination; Female; Graft vs Host Disease; Humans; Incidence; Japan; Leukemia, Myeloid; Male; Methotrexate; Methylprednisolone; Middle Aged; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Severity of Illness Index | 1993 |
Circadian time-dependent response of childhood lymphoblastic leukemia to chemotherapy: a long-term follow-up study of survival.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Circadian Rhythm; Drug Administration Schedule; Follow-Up Studies; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Recurrence; Regression Analysis; Survival Analysis; Time Factors; Vincristine | 1993 |
Follow-up of the first two successive German multicentre trials for adult ALL (01/81 and 02/84). German Adult ALL Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Administration Schedule; Follow-Up Studies; Humans; Mediastinum; Mercaptopurine; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Survival Analysis; Teniposide; Vincristine | 1993 |
Treatment results of three consecutive Brazilian cooperative childhood ALL protocols: GBTLI-80, GBTLI-82 and -85. ALL Brazilian Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Drug Administration Schedule; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Teniposide; Vincristine | 1993 |
Chemotherapy versus allogeneic bone marrow transplantation in adults with acute lymphoblastic leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Cyclosporine; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Analysis; Transplantation, Homologous; Whole-Body Irradiation | 1993 |
Prevention of CNS disease in intermediate-risk acute lymphoblastic leukemia: comparison of cranial radiation and intrathecal methotrexate and the importance of systemic therapy: a Childrens Cancer Group report.
Topics: Adolescent; Adult; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Injections, Spinal; Life Tables; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Survival Analysis | 1993 |
Improved outcome with delayed intensification for children with acute lymphoblastic leukemia and intermediate presenting features: a Childrens Cancer Group phase III trial.
Topics: Adolescent; Adult; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Drug Administration Schedule; Female; Humans; Infant; Injections, Spinal; Life Tables; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Survival Analysis; Treatment Outcome | 1993 |
Randomized comparison of 36-hour intermediate-dose versus 4-hour high-dose methotrexate infusions for remission induction in relapsed childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 1993 |
[Results of the CCLSG high risk ALL 874 protocol in childhood acute lymphoblastic leukemia. Children's Cancer and Leukemia Study Group].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Risk; Vincristine | 1993 |
Severe toxicity limits intensification of induction therapy for acute lymphoblastic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Idarubicin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Vincristine | 1993 |
Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Stomatitis | 1996 |
Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia.
Topics: Adolescent; Allopurinol; Analysis of Variance; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Humans; Infant; Linear Models; Lymphocytes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines | 1996 |
A randomized phase-III study of the efficacy of granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia. Berlin-Frankfurt-Münster Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Etoposide; Female; Fever; Filgrastim; Gastrointestinal Diseases; Germany; Granulocyte Colony-Stimulating Factor; Hematologic Diseases; Humans; Ifosfamide; Infant; Infection Control; Life Tables; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prospective Studies; Recombinant Proteins; Risk; Survival Analysis; Thioguanine; Vincristine; Vindesine | 1996 |
Randomized comparison of moderate-dose methotrexate infusions to oral methotrexate in children with intermediate risk acute lymphoblastic leukemia: a Childrens Cancer Group study.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Injections, Spinal; Leucovorin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Survival Analysis; Vincristine | 1996 |
The GIMEMA ALL 0183 trial: analysis of 10-year follow-up. GIMEMA Cooperative Group, Italy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Follow-Up Studies; Humans; Idarubicin; Male; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Analysis; Survival Rate | 1996 |
Cytoreduction and prognosis in acute lymphoblastic leukemia--the importance of early marrow response: report from the Childrens Cancer Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Combined Modality Therapy; Cyclophosphamide; Daunorubicin; Disease-Free Survival; Humans; Lymphocyte Count; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Vincristine | 1996 |
Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small noncleaved-cell lymphoma: a pediatric oncology group study.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infant; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Treatment Outcome; Vincristine | 1996 |
Relationship between minimal residual disease and outcome in adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Bone Marrow Transplantation; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Neoplasm; Etoposide; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Humans; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm, Residual; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Survival Analysis; Treatment Outcome; Vincristine | 1996 |
Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Base Sequence; Child; Child, Preschool; Chromosomes, Human, Pair 22; Chromosomes, Human, Pair 9; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Fusion Proteins, bcr-abl; Germany; Humans; Incidence; Infant; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mercaptopurine; Methotrexate; Molecular Sequence Data; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Transcription, Genetic; Translocation, Genetic; Vincristine | 1996 |
[Chemotherapy for B lymphoid malignancy in childhood--results in BLK88 protocol].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Doxorubicin; Female; Humans; Injections, Spinal; Lymphoma, B-Cell; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 1996 |
Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group.
Topics: Age of Onset; Analysis of Variance; Austria; Chi-Square Distribution; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Evoked Potentials, Visual; Female; Follow-Up Studies; Germany; Humans; Intelligence; Male; Methotrexate; Odds Ratio; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors | 1996 |
Low incidence of CNS relapse with cranial radiotherapy and intrathecal methotrexate in acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Disease-Free Survival; Female; Humans; Leukemic Infiltration; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Acute lymphoblastic leukemia in children: nonrandomized comparison of conventional vs. intensive chemotherapy at the National Cancer Institute of Colombia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Drug Administration Schedule; Feasibility Studies; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Treatment Outcome; Vincristine | 1997 |
Intermediate-dose methotrexate versus cranial irradiation in childhood acute lymphoblastic leukemia: a ten-year follow-up.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 1997 |
Monitoring of methotrexate and 7-hydroxymethotrexate in saliva from children with acute lymphoblastic leukemia receiving high-dose consolidation treatment: relation to oral mucositis.
Topics: Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Stomatitis; Time Factors | 1997 |
Eighty-one percent event-free survival in advanced Burkitt's lymphoma/leukemia: no differences in outcome between pediatric and adult patients treated with the same intensive pediatric protocol.
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Granulocyte Colony-Stimulating Factor; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Treatment Outcome; Vincristine | 1997 |
B-lineage acute lymphoblastic leukemia of childhood. An institutional experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Burkitt Lymphoma; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Female; Humans; Immunophenotyping; Infant; Life Tables; Male; Mercaptopurine; Methotrexate; Neprilysin; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Risk Factors; Survival Analysis; Teniposide; Treatment Outcome; Vincristine | 1997 |
Autologous transplantation with CD52 monoclonal antibody-purged marrow for acute lymphoblastic leukemia: long-term follow-up.
Topics: Adolescent; Adult; Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Bone Marrow Transplantation; CD52 Antigen; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Glycoproteins; Humans; Male; Melphalan; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Time Factors; Transplantation, Autologous; Whole-Body Irradiation | 1997 |
Age-adapted induction treatment of acute lymphoblastic leukemia in the elderly and assessment of maintenance with interferon combined with chemotherapy. A multicentric prospective study in forty patients. French Group for Treatment of Adult Acute Lymphobl
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Daunorubicin; Disease-Free Survival; Female; Humans; Interferons; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Steroids; Vincristine | 1997 |
Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies.
Topics: Allopurinol; Antimetabolites; Antineoplastic Agents; Child; Child, Preschool; Female; Humans; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Urate Oxidase; Uric Acid | 1997 |
Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Cytarabine; Dexamethasone; Erythrocytes; Etoposide; Female; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine; Vincristine | 1997 |
Intensified therapy for infants with acute lymphoblastic leukemia: results from the Dana-Farber Cancer Institute Consortium.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Core Binding Factor Alpha 2 Subunit; Cytarabine; Disease-Free Survival; DNA-Binding Proteins; DNA, Neoplasm; Female; Histone-Lysine N-Methyltransferase; Humans; Infant; Infant, Newborn; Male; Mercaptopurine; Methotrexate; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proto-Oncogenes; Remission Induction; Survival Rate; Transcription Factors; Treatment Outcome; Vincristine | 1997 |
A comparative study of the long term psychosocial functioning of childhood acute lymphoblastic leukemia survivors treated by intrathecal methotrexate with or without cranial radiation.
Topics: Achievement; Adolescent; Adult; Antimetabolites, Antineoplastic; Behavior; Body Image; Child; Clinical Trials, Phase III as Topic; Cranial Irradiation; Disease-Free Survival; Education; Employment; Female; Humans; Injections, Intravenous; Injections, Spinal; Interviews as Topic; Longitudinal Studies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Self Concept; Sexual Behavior; Social Adjustment; Social Behavior; Stress, Psychological; Survivors; Telephone | 1998 |
Intermediate-dose intravenous methotrexate with intravenous mercaptopurine is superior to repetitive low-dose oral methotrexate with intravenous mercaptopurine for children with lower-risk B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group
Topics: Administration, Oral; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child, Preschool; Female; Humans; Infusions, Intravenous; Leucovorin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Remission Induction; Sex Factors; Treatment Failure | 1998 |
Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Infant; Leukemia, B-Cell; Male; Metabolic Clearance Rate; Methotrexate; Patient Care Planning; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Prospective Studies; Remission Induction; Survival Analysis; Teniposide | 1998 |
Response of children with high-risk acute lymphoblastic leukemia treated with and without cranial irradiation: a report from the Children's Cancer Group.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Remission Induction; Survival Analysis | 1998 |
Estimated 6-year event-free survival of 55% in 60 consecutive adult acute lymphoblastic leukemia patients treated with an intensive phase II protocol based on high induction dose of daunorubicin.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Treatment Outcome; Vincristine | 1998 |
Demyelination and single-carbon transfer pathway metabolites during the treatment of acute lymphoblastic leukemia: CSF studies.
Topics: Antidotes; Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Demyelinating Diseases; Drug Interactions; Humans; Infant; Leucovorin; Methionine; Methotrexate; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Tetrahydrofolates | 1998 |
Profound abnormality of the B/T lymphocyte ratio during chemotherapy for pediatric acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; CD4 Lymphocyte Count; Child; Child, Preschool; Female; Flow Cytometry; Humans; Immunoglobulin G; Immunoglobulin M; Lymphocyte Subsets; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; T-Lymphocytes | 1998 |
Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy--a Pediatric Oncology Group study.
Topics: Acute Disease; Administration, Oral; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Injections, Spinal; Leucovorin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Tomography, X-Ray Computed | 1998 |
Oral versus intravenous methotrexate: another opinion.
Topics: Administration, Oral; Child; Drug Administration Schedule; Humans; Infusions, Intravenous; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1998 |
Improved survival with early intensification: combined results from the Medical Research Council childhood ALL randomised trials, UKALL X and UKALL XI. Medical Research Council Working Party on Childhood Leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Daunorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Thioguanine; Vincristine | 1998 |
Transient encephalopathy following high-dose methotrexate treatment in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Female; Humans; Incidence; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1998 |
Analysis of the immunophenotype of children treated on the Medical Research Council United Kingdom Acute Lymphoblastic Leukaemia Trial XI (MRC UKALLXI). Medical Research Council Childhood Leukaemia Working Party.
Topics: Adolescent; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers, Tumor; CD13 Antigens; Child; Child, Preschool; Daunorubicin; Disease-Free Survival; Female; Humans; Immunophenotyping; Infant; Leukocyte Count; Male; Methotrexate; Neprilysin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Sialic Acid Binding Ig-like Lectin 3; Vincristine | 1998 |
Is high dose methotrexate without irradiation of the brain sufficiently effective in prevention of CNS disease in children with acute lymphoblastic leukemia?
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk | 1998 |
Changes in red blood cell methotrexate pharmacology and their impact on outcome when cytarabine is infused with methotrexate in the treatment of acute lymphocytic leukemia in children: a pediatric oncology group study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Erythrocytes; Humans; Infant; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies | 1996 |
Intensive BFM chemotherapy for childhood ALL: interim analysis of the AIEOP-ALL 91 study. Associazione Italiana Ematologia Oncologia Pediatrica.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Chromosome Aberrations; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Humans; Infant; Italy; Leucovorin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Risk; Thioguanine; Treatment Outcome; Vincristine | 1998 |
[Studies of childhood non-Hodgkin's lymphoma--treatment results with the CCLSG NHL 960 protocol. Children's Cancer and Leukemia Study Group (CCLSG)].
Topics: Adolescent; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Etoposide; Female; Humans; Hydrocortisone; Infant; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine | 1998 |
Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation.
Topics: Carrier Proteins; Cell Lineage; Child; Child, Preschool; Chromosomes, Human, Pair 21; Humans; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Ploidies; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 1999 |
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; gamma-Glutamyl Hydrolase; Glutamic Acid; Humans; Infant; Male; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
Improvement in CNS protective treatment in non-high-risk childhood acute lymphoblastic leukemia: report from the Japanese Children's Cancer and Leukemia Study Group.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Infant; Injections, Spinal; Japan; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Treatment Outcome | 1999 |
Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Remission Induction; Survival Rate | 1999 |
Improved outcome for acute lymphoblastic leukemia in children of a developing country: results of the Chilean National Trial PINDA 87.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chile; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Developing Countries; Female; Humans; Immunophenotyping; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Survival Analysis; Vincristine | 1999 |
Metabolites of mercaptopurine in red blood cells: a relationship between 6-thioguanine nucleotides and 6-methylmercaptopurine metabolite concentrations in children with lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Female; Guanine Nucleotides; Humans; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 1999 |
Long-term follow-up results of adult patients with acute lymphocytic leukemia or lymphoblastic lymphoma treated with short-term, alternating non-cross-resistant chemotherapy: Japan Clinical Oncology Group Study 8702. Lymphoma Study Group.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Survival Analysis; Treatment Outcome; Vincristine | 1999 |
Persistence of peripheral blood and bone marrow blasts during remission induction in adult acute lymphoblastic leukemia confers a poor prognosis depending on treatment intensity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Humans; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Time Factors; Vincristine | 1999 |
Combination therapy with methotrexate, vincristine, polyethylene-glycol conjugated-asparaginase, and prednisone in the treatment of patients with refractory or recurrent acute lymphoblastic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Drug Administration Schedule; Enzymes, Immobilized; Female; Humans; L-Lactate Dehydrogenase; Male; Methotrexate; Middle Aged; Philadelphia Chromosome; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Treatment Outcome; Vincristine | 1999 |
A randomised dose-comparison trial of granisetron in preventing emesis in children with leukaemia receiving emetogenic chemotherapy.
Topics: Adolescent; Antiemetics; Antineoplastic Agents; Child; Child, Preschool; Cross-Over Studies; Cytarabine; Dose-Response Relationship, Drug; Female; Granisetron; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
[Prevention of neuroleukemia by intrathecal administration of cytosar and methotrexate in acute lymphoblastic leukemia in adults].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Drug Therapy, Combination; Female; Humans; Immunophenotyping; Injections, Spinal; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk Factors; Treatment Outcome | 1999 |
Effective preventive central nervous system therapy with extended triple intrathecal therapy and the modified ALL-BFM 86 chemotherapy program in an enlarged non-high risk group of children and adolescents with non-B-cell acute lymphoblastic leukemia: the
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Cytarabine; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Israel; Life Tables; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Risk; Treatment Outcome | 2000 |
Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cranial Irradiation; Disease-Free Survival; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Probability; Remission Induction; Time Factors | 2000 |
Effects of G-CSF and high-dose methylprednisolone on peripheral stem cells, serum IL-3 levels and hematological parameters in acute lymphoblastic leukemia patients with neutropenia: a pilot study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Etoposide; Glucocorticoids; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Interleukin-3; Methotrexate; Methylprednisolone; Neutropenia; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine | 2000 |
Intensification with intermediate-dose intravenous methotrexate is effective therapy for children with lower-risk B-precursor acute lymphoblastic leukemia: A Pediatric Oncology Group study.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Survival Analysis | 2000 |
Benefit of intensified treatment for all children with acute lymphoblastic leukaemia: results from MRC UKALL XI and MRC ALL97 randomised trials. UK Medical Research Council's Working Party on Childhood Leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; Humans; Infant; Infections; Male; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Proportional Hazards Models; Remission Induction; Risk; Survival Analysis; Thioguanine; Treatment Outcome; Vincristine | 2000 |
Six months of maintenance chemotherapy after intensified treatment for acute lymphoblastic leukemia of childhood.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk Factors; Treatment Outcome | 2000 |
Use of recombinant human granulocyte colony-stimulating factor to increase chemotherapy dose-intensity: a randomized trial in very high-risk childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dexamethasone; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Infant; Infant, Newborn; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recombinant Proteins; Thrombocytopenia; Treatment Outcome; Vincristine | 2000 |
[Treatment of adult acute lymphoblastic leukemia by KHALL-93--long-term outcome].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Treatment Outcome | 2000 |
Comparison of the L10M consolidation regimen to an alternative regimen including escalating methotrexate/L-asparaginase for adult acute lymphoblastic leukemia: a Southwest Oncology Group Study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Disease-Free Survival; Dose-Response Relationship, Drug; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Analysis | 2001 |
6-mercaptopurine dosage and pharmacokinetics influence the degree of bone marrow toxicity following high-dose methotrexate in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2001 |
Effects of high-dose methotrexate on the hemostatic system in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Blood Coagulation Disorders; Blood Coagulation Factor Inhibitors; Blood Coagulation Factors; Blood Coagulation Tests; Child; Child, Preschool; Female; Hemostasis; Humans; Male; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2001 |
Value of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of
Topics: Actuarial Analysis; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System; Child; Child, Preschool; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Synergism; Europe; Female; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Injections, Spinal; Leukemic Infiltration; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Regression Analysis; Risk; Vincristine | 2001 |
Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Female; Humans; Infant; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Risk Factors; Sex Factors; Thioguanine; United Kingdom; Vincristine | 2001 |
The Société Française d'Oncologie Pédiatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Humans; Hydrocortisone; Infant; Leucovorin; Lymphoma, B-Cell; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Remission Induction; Survival Rate; Vincristine | 2001 |
Daunorubicin continuous infusion induces more toxicity than bolus infusion in acute lymphoblastic leukemia induction regimen: a randomized study.
Topics: Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Carmustine; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Etoposide; Female; Gram-Negative Bacterial Infections; Humans; Immunocompromised Host; Infusions, Intravenous; Injections, Intravenous; Life Tables; Male; Methotrexate; Middle Aged; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Thrombocytopenia; Treatment Outcome; Vincristine | 2001 |
Risk-oriented postremission strategies in adult acute lymphoblastic leukemia: prospective confirmation of anthracycline activity in standard-risk class and role of hematopoietic stem cell transplants in high-risk groups.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Idarubicin; Male; Melphalan; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Transplantation, Homologous; Whole-Body Irradiation | 2001 |
Metabolic functions of the liver during chemotherapy in children with acute lymphoblastic leukemia.
Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antipyrine; Child; Child, Preschool; Half-Life; Humans; Liver; Liver Function Tests; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2001 |
Outcome of acute lymphoblastic leukemia in children with AL90 regimen: impact of response to treatment and sex difference on prognostic factors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Drug Administration Schedule; Etoposide; Female; Humans; Immunophenotyping; Infant; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Radiotherapy, Adjuvant; Remission Induction; Risk; Risk Factors; Severity of Illness Index; Sex Factors; Survival Analysis; Treatment Outcome; Vincristine | 2001 |
Brief-duration high-intensity chemotherapy for patients with small noncleaved-cell lymphoma or FAB L3 acute lymphocytic leukemia: results of cancer and leukemia group B study 9251.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Infections; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survival Analysis; Thrombocytopenia; Vincristine | 2001 |
Favorable outcome for children and adolescents with T-cell lymphoblastic lymphoma with an intensive ALL-type therapy without local radiotherapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Austria; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Female; Germany; Humans; Immunophenotyping; Infant; Life Tables; Lymphoma, T-Cell; Male; Mercaptopurine; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiotherapy, Adjuvant; Remission Induction; Thioguanine; Treatment Outcome; Vincristine | 2001 |
Less intense conditioning with fludarabine, cyclophosphamide, idarubicin and etoposide (FCIE) followed by allogeneic unselected peripheral blood stem cell transplantation in elderly patients with leukemia.
Topics: Adult; Aged; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Cyclosporine; Etoposide; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Idarubicin; Immunosuppressive Agents; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Chronic-Phase; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Transplantation Conditioning; Transplantation, Homologous; Vidarabine | 2002 |
Quantitative MRI assessment of leukoencephalopathy.
Topics: Adult; Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child; Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2002 |
Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
Topics: Adult; Age Factors; Antimetabolites, Antineoplastic; Azathioprine; Child; Drug Therapy, Combination; Erythrocytes; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methotrexate; Methyltransferases; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioinosine; Thionucleotides | 2002 |
Adult lymphoblastic lymphoma: high incidence of central nervous system relapse in patients treated with the Stanford University protocol.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Neoplasms; Cyclophosphamide; Doxorubicin; Humans; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Treatment Outcome | 1992 |
Treatment of acute lymphoblastic leukaemia (ALL).
Topics: Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infusions, Intravenous; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Analysis; Vincristine | 1992 |
Treatment of advanced stage T cell lymphoblastic lymphoma: results of the United Kingdom Children's Cancer Study Group (UKCCSG) protocol 8503.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Daunorubicin; Humans; Infant; Mercaptopurine; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination; Vincristine | 1992 |
Efficacy of intrathecal methotrexate with and without cranial radiotherapy in preventing central nervous system relapses in acute lymphocytic leukemia.
Topics: Adolescent; Brain; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Treatment Outcome | 1992 |
Red blood cell methotrexate and folate levels in children with acute lymphoblastic leukemia undergoing therapy: a Pediatric Oncology Group pilot study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Drug Monitoring; Erythrocytes; Folic Acid; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors | 1992 |
F-MACHOP in advanced aggressive lymphoma.
Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Fluorouracil; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 1992 |
IgG subclass imbalance in children with acute lymphoblastic leukemia receiving maintenance chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dysgammaglobulinemia; Female; Humans; IgG Deficiency; Immune Tolerance; Immunoglobulin Fragments; Immunoglobulin G; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 1992 |
Long-term neuropsychologic sequelae of childhood leukemia: comparison of two CNS prophylactic regimens.
Topics: Adolescent; Age Factors; Brain; Brain Neoplasms; Child; Cognition Disorders; Combined Modality Therapy; Cytarabine; Female; Humans; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 1992 |
Late intensification therapy in adult acute lymphoid leukemia. The Southeastern Cancer Study Group Experience.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Vincristine | 1992 |
Impact of three methods of treatment intensification on acute lymphoblastic leukemia in children: long-term results of St Jude total therapy study X.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Methotrexate; Outcome Assessment, Health Care; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction | 1992 |
The relationship of sex and treatment modality to neuropsychologic outcome in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Analysis of Variance; Child; Child, Preschool; Cognition; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Intelligence; Intelligence Tests; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors | 1992 |
Treatment of acute lymphoblastic leukemia French protocol Fralle 83-87.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Drug Administration Schedule; Female; France; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Risk Factors; Vincristine; Vindesine | 1992 |
MRC UKALL X. The UK protocol for childhood ALL: 1985-1990. The Medical Research Council Working Party on Childhood Leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Preschool; Clinical Protocols; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; United Kingdom | 1992 |
Adult acute lymphocytic leukemia: the Eastern Cooperative Oncology Group experience.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Administration Schedule; Humans; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Thioguanine; Vincristine | 1992 |
Early intensification followed by allo-BMT or auto-BMT or a second intensification in adult ALL: a randomized multicenter study.
Topics: Adolescent; Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Feasibility Studies; Humans; Italy; Methotrexate; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Transplantation, Autologous; Transplantation, Homologous; Vincristine | 1992 |
Marked increase in veno-occlusive disease of the liver associated with methotrexate use for graft-versus-host disease prophylaxis in patients receiving busulfan/cyclophosphamide.
Topics: Actuarial Analysis; Adult; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Female; Follow-Up Studies; Graft vs Host Disease; Hepatic Veno-Occlusive Disease; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Whole-Body Irradiation | 1992 |
[Second cessation of therapy in children with acute lymphoblastic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Infant; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Time Factors; Vincristine | 1992 |
Total body irradiation with or without lung shielding for allogeneic bone marrow transplantation.
Topics: Adult; Bone Marrow Transplantation; Cyclophosphamide; Dose-Response Relationship, Radiation; Female; Graft vs Host Disease; Humans; Incidence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lung; Lung Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiation Protection; Transplantation, Homologous; Whole-Body Irradiation | 1992 |
Deterioration of intellect among children surviving leukemia: IQ test changes modify estimates of treatment toxicity.
Topics: Age Factors; Child; Child, Preschool; Female; Humans; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Wechsler Scales | 1992 |
[Treatment of acute lymphoblastic leukemia in children. Results of the FRALLE 83 protocol].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Clinical Protocols; Cyclophosphamide; Daunorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Vincristine | 1991 |
Retrospective analysis of late intensification therapy with high-dose methotrexate for standard-risk acute lymphoblastic leukemia in childhood (CCLSG-S811 study). The Children's Cancer and Leukemia Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cranial Irradiation; Humans; Infant; Leucovorin; Life Tables; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Retrospective Studies; Survival Rate; Vincristine | 1991 |
Low-dose versus high-dose methotrexate during remission induction in childhood acute lymphoblastic leukemia (Protocol 81-01 update).
Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cytarabine; Dose-Response Relationship, Drug; Doxorubicin; Follow-Up Studies; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Time Factors; Treatment Outcome; Vincristine | 1991 |
Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission after intensive primary and relapse therapy according to the BFM- and CoALL-protocols: results of the German Cooperative Study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Cyclophosphamide; Cyclosporine; Daunorubicin; Etoposide; Follow-Up Studies; Graft vs Host Disease; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Time Factors; Transplantation, Homologous; Vincristine; Whole-Body Irradiation | 1991 |
How much is too much? Folinic acid rescue dose in children with acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Retrospective Studies; Risk Factors | 1991 |
The influence of serum methotrexate concentrations and drug dosage on outcome in childhood acute lymphoblastic leukaemia.
Topics: Administration, Oral; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Injections, Intramuscular; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Random Allocation | 1991 |
Six-year experience with a comprehensive approach to the treatment of recurrent childhood acute lymphoblastic leukemia (ALL-REZ BFM 85). A relapse study of the BFM group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Testicular Neoplasms | 1991 |
Intellectual function in long-term survivors of childhood acute lymphoblastic leukemia: protective effect of pre-irradiation methotrexate? A Childrens Cancer Study Group study.
Topics: Asparaginase; Brain; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Infant; Injections, Spinal; Intelligence; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiation-Protective Agents; Radiation, Ionizing; Radiography; Radiotherapy; Regression Analysis; Vincristine | 1991 |
High survival rate in advanced-stage B-cell lymphomas and leukemias without CNS involvement with a short intensive polychemotherapy: results from the French Pediatric Oncology Society of a randomized trial of 216 children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Female; Follow-Up Studies; Humans; Infant; Lymphoma, B-Cell; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Survival Rate; Vincristine | 1991 |
HiC-COM: a 2-month intensive chemotherapy regimen for children with stage III and IV Burkitt's lymphoma and B-cell acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Methotrexate; Neoplasm Staging; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Vincristine | 1991 |
A phase II study of combined methotrexate and teniposide infusions prior to reinduction therapy in relapsed childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Drug Evaluation; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Teniposide | 1991 |
Comparison of neuropsychologic functioning and clinical indicators of neurotoxicity in long-term survivors of childhood leukemia given cranial radiation or parenteral methotrexate: a prospective study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Electroencephalography; Female; Humans; Infusions, Parenteral; Intelligence Tests; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiation Injuries | 1991 |
A pilot study of intermediate-dose methotrexate and cytosine arabinoside, "spread-out" or "up-front," in continuation therapy for childhood non-T, non-B acute lymphoblastic leukemia. A Pediatric Oncology Group study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Female; Fever; Humans; Infant; Infections; Length of Stay; Leukocyte Count; Male; Methotrexate; Neutropenia; Pilot Projects; Platelet Count; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Survival Rate | 1991 |
Autologous bone marrow transplantation for high-grade lymphoid malignancy using melphalan/irradiation conditioning without marrow purging or cryopreservation. The Northern Regional Bone Marrow Transplant Group.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Cryopreservation; Female; Follow-Up Studies; Humans; Lymphoma, Non-Hodgkin; Male; Melphalan; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Transplantation, Autologous | 1991 |
Parental report of everyday cognitive abilities among children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Brain Neoplasms; Child; Cognition Disorders; Cranial Irradiation; Female; Humans; Injections, Spinal; Intelligence Tests; Learning Disabilities; Male; Methotrexate; Neuropsychological Tests; Parents; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
Monthly pulses of vincristine and prednisone prevent bone marrow and testicular relapse in low-risk childhood acute lymphoblastic leukemia: a report of the CCG-161 study by the Childrens Cancer Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Brain Neoplasms; Child, Preschool; Combined Modality Therapy; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Random Allocation; Recurrence; Remission Induction; Survival Rate; Testicular Neoplasms; Vincristine | 1991 |
Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Daunorubicin; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Methotrexate; Middle Aged; Mitoxantrone; Nervous System Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
Results of Medical Research Council Childhood Leukaemia Trial UKALL VIII (report to the Medical Research Council on behalf of the Working Party on Leukaemia in Childhood).
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Random Allocation; United Kingdom; Vincristine | 1991 |
A prospective comparison of neuropsychologic performance of children surviving leukemia who received 18-Gy, 24-Gy, or no cranial irradiation.
Topics: Adolescent; Age Factors; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Dose-Response Relationship, Radiation; Female; Humans; Infant; Intelligence; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Psychomotor Performance; Radiotherapy Dosage; Remission Induction; Time Factors; Verbal Behavior | 1991 |
CSF drug levels for children with acute lymphoblastic leukemia treated by 5 g/m2 methotrexate. A study from the EORTC Children's Leukemia Cooperative Group.
Topics: Adolescent; Age Factors; Analysis of Variance; Child; Child, Preschool; Europe; Female; Humans; Infant; Infusions, Intravenous; Male; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
Treatment of relapsed acute lymphocytic leukemia in adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Brain Neoplasms; Combined Modality Therapy; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Female; Germany, West; Humans; Ifosfamide; Leucovorin; Life Tables; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Spinal Cord Neoplasms; Teniposide; Testicular Neoplasms; Vindesine | 1990 |
Impact of early intensive reinduction therapy on event-free survival in children with low-risk acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Daunorubicin; Dexamethasone; Doxorubicin; Germany, West; Humans; Leucovorin; Life Tables; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Randomized Controlled Trials as Topic; Risk; Survival Rate; Thioguanine; Vincristine | 1990 |
Improved prognosis for childhood acute lymphocytic leukemia with very high white blood cell count (greater than 100/nl) with rotation of non-cross-resistant drug combinations.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Germany, West; Humans; Infant; Infant, Newborn; Leukocyte Count; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Randomized Controlled Trials as Topic; Risk; Survival Rate; Teniposide; Thioguanine; Vincristine | 1990 |
Prognosis of initial CNS involvement in acute lymphoblastic leukemia childhood.
Topics: Brain Neoplasms; Child; Combined Modality Therapy; Germany, East; Germany, West; Gold Radioisotopes; Humans; Life Tables; Meningeal Neoplasms; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiography; Remission Induction; Risk; Spinal Cord Neoplasms; Survival Rate | 1990 |
Central nervous system relapse prevention in 1165 standard-risk children with acute lymphoblastic leukemia in five BFM trials.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Combined Modality Therapy; Germany, West; Humans; Injections, Spinal; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Spinal Cord Neoplasms | 1990 |
Risk of CNS relapse after systemic relapse of childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Female; Germany, West; Humans; Infusions, Intravenous; Injections, Spinal; Life Tables; Male; Methotrexate; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Spinal Cord Neoplasms | 1990 |
Pharmacokinetics of continuous infusion of methotrexate and teniposide in pediatric cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials as Topic; Drug Administration Schedule; Humans; Infusions, Intravenous; Leucovorin; Metabolic Clearance Rate; Methotrexate; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide | 1990 |
Teniposide (VM-26) and continuous infusion cytosine arabinoside for initial induction failure in childhood acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Hydrocortisone; Infant; Infusions, Intravenous; Male; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Teniposide; United States | 1990 |
Interaction between trimethoprim-sulfamethoxazole and methotrexate in children with leukemia.
Topics: Bone Marrow; Child; Child, Preschool; Drug Interactions; Female; Half-Life; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Trimethoprim, Sulfamethoxazole Drug Combination | 1990 |
Biochemical interactions between methotrexate and 1-beta-D-arabinofuranosylcytosine in hematopoietic cells of children: a Pediatric Oncology Group study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cells, Cultured; Child; Cytarabine; DNA, Neoplasm; Drug Evaluation; Drug Synergism; Hematopoietic Stem Cells; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 1990 |
Influence of age, sex, and concurrent intrathecal methotrexate therapy on intellectual function after cranial irradiation during childhood: a report from the Children's Cancer Study Group.
Topics: Age Factors; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Injections, Spinal; Intelligence; Male; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors | 1990 |
The prognostic value of testicular biopsy in childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biopsy; Child; Combined Modality Therapy; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Radiotherapy Dosage; Remission Induction; Testicular Neoplasms; Testis; Time Factors; Vincristine | 1990 |
Neurotoxicity in lymphoblastic leukaemia: comparison of oral and intramuscular methotrexate and two doses of radiation.
Topics: Administration, Oral; Brain; Brain Diseases; Calcinosis; Child; Child, Preschool; Combined Modality Therapy; Humans; Infant; Injections, Intramuscular; Injections, Spinal; Intelligence Tests; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Random Allocation; Tomography, X-Ray Computed | 1990 |
Effect of methotrexate on relapse after bone-marrow transplantation for acute lymphoblastic leukaemia. International Bone Marrow Transplant Registry.
Topics: Actuarial Analysis; Adolescent; Adult; Bone Marrow Transplantation; Child; Cyclosporins; Drug Evaluation; Graft vs Host Disease; Humans; Methotrexate; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 1989 |
Three versus five years of maintenance therapy are equivalent in childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biopsy; Child; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Radiotherapy Dosage; Random Allocation; Remission Induction; Sex Factors; Testis; Time Factors; Vincristine | 1989 |
Treatment of childhood acute lymphoblastic leukemia with protocol TCL821: a report of Taiwan Children's Cancer Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Dexamethasone; Doxorubicin; Evaluation Studies as Topic; Female; Follow-Up Studies; Humans; Hydrocortisone; Infant; Male; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Taiwan; Vincristine | 1989 |
[Treatment of childhood acute lymphoblastic leukemia: randomized trials of protocols CCLSG-L 841 and I 841. (Phase III study). Children's Cancer and Leukemia Study Group].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Combined Modality Therapy; Doxorubicin; Female; Humans; Infant; Japan; Male; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Randomized Controlled Trials as Topic; Remission Induction; Risk Factors; Vincristine | 1989 |
Early response to induction therapy as a predictor of disease-free survival and late recurrence of childhood acute lymphoblastic leukemia: a report from the Childrens Cancer Study Group.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Humans; Methotrexate; Multicenter Studies as Topic; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Analysis; Vincristine | 1989 |
Intensive therapy for children with acute lymphoblastic leukaemia and unfavourable presenting features. Early conclusions of study CCG-106 by the Childrens Cancer Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Combinations; Female; Humans; Infant; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy Dosage; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1988 |
A comparison of two regimens for high-risk acute lymphocytic leukemia in childhood. A Pediatric Oncology Group Study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Humans; Hydrocortisone; Infant; Infant, Newborn; Infections; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prospective Studies; Random Allocation; Remission Induction; Vincristine | 1989 |
High-dose methotrexate improves clinical outcome in children with acute lymphoblastic leukemia: St. Jude Total Therapy Study X.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Random Allocation; Teniposide | 1988 |
A prospective randomised trial of cyclosporin versus methotrexate after HLA-identical sibling marrow transplantation for patients with acute leukemia in first remission: analysis 2.5 years after last patient entry.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Clinical Trials as Topic; Cyclosporins; Female; Graft Survival; Graft vs Host Disease; Histocompatibility Testing; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Random Allocation; Remission Induction | 1988 |
Isolated central nervous system relapse in acute lymphocytic leukemia (ALL) in children. Experiences of the Swiss Pediatric Oncology Group (SPOG/SAKK) 1976-1986.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Female; Humans; Hydrocortisone; Infant; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Switzerland | 1988 |
Randomized multicentric Italian study on two treatment regimens for marrow relapse in childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Combinations; Humans; Italy; Life Tables; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Thioguanine; Vincristine | 1986 |
1094 other study(ies) available for methotrexate and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Lacticaseibacillus casei; Leucovorin; Methotrexate; Molecular Structure; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recombinant Proteins; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
[Methotrexate-induced stroke-like syndrome: A pediatric case report].
Topics: Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke | 2021 |
Plasma Distribution of Methotrexate and Its Polyglutamates in Pediatric Acute Lymphoblastic Leukemia: Preliminary Insights.
Topics: Antimetabolites, Antineoplastic; Child; Chromatography, Liquid; Humans; Male; Methotrexate; Plasma; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 2022 |
Myelopathy associated with intrathecal methotrexate.
Topics: Adult; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Subacute Combined Degeneration; Young Adult | 2022 |
Simultaneous determination of folate and methotrexate metabolites in serum by LC-MS/MS during high-dose methotrexate therapy.
Topics: Antineoplastic Agents; Chromatography, Liquid; Dose-Response Relationship, Drug; Folic Acid; Humans; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tandem Mass Spectrometry | 2021 |
Intrathecal therapy in acute lymphoblastic leukemia case with spinal deformity.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
High-dose methotrexate therapy for a child with B-cell precursor acute lymphoblastic leukemia and congenital solitary kidney.
Topics: Burkitt Lymphoma; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solitary Kidney | 2022 |
Upper gastrointestinal bleeding secondary to toxicity by anthracyclines, cytarabine and methotrexate in a patient with acute lymphoblastic leukemia.
Topics: Acute Disease; Anthracyclines; Cytarabine; Gastrointestinal Hemorrhage; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ulcer | 2022 |
Evaluation of cytogenetic and molecular markers with MTX-mediated toxicity in pediatric acute lymphoblastic leukemia patients.
Topics: Adolescent; Child; Child, Preschool; Cytogenetic Analysis; Drug-Related Side Effects and Adverse Reactions; Genotype; Humans; Infant; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Hypersensitivity reaction to high-dose methotrexate and methotrexate-induced acral erythema in a child with acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Erythema; Humans; Hypersensitivity; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia: phenotypes, risk factors and genotypes.
Topics: Antineoplastic Combined Chemotherapy Protocols; Australia; Central Nervous System; Genome-Wide Association Study; Genotype; Humans; Methotrexate; Phenotype; Posterior Leukoencephalopathy Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Seizures | 2022 |
Analysis of the frequency distribution of five single-nucleotide polymorphisms of the MTRRgene in a Chinese pediatric population with acute lymphoblastic leukemia.
Topics: Child; Ferredoxin-NADP Reductase; Gene Frequency; Genotype; Humans; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies | 2022 |
Hypoalbuminemia and not undernutrition predicts high-dose methotrexate-induced nephrotoxicity in children with acute lymphoblastic leukemia in resource-constrained centers.
Topics: Child; Humans; Hypoalbuminemia; Kidney; Leucovorin; Malnutrition; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2022 |
Sex-Based Differences in Functional Brain Activity During Working Memory in Survivors of Pediatric Acute Lymphoblastic Leukemia.
Topics: Adolescent; Child; Female; Humans; Male; Memory, Short-Term; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prefrontal Cortex; Survivors | 2022 |
Methotrexate-induced Leukoencephalopathy: A Rare but Life-threatening Toxicity.
Topics: Acute Disease; Female; Humans; Leukoencephalopathies; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
High-dose methotrexate-related pneumonitis in a child with acute lymphoblastic leukemia.
Topics: Adolescent; Adrenal Cortex Hormones; Child; Female; Humans; Methotrexate; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed | 2023 |
Dose-individualization Efficiently Maintains Sufficient Exposure to Methotrexate without Additional Toxicity in High-dose Methotrexate Regimens for Pediatric Acute Lymphoblastic Leukemia.
Topics: Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2022 |
Long-term results of the treatment of adolescents and adults with acute lymphoblastic leukemia with a pediatric-inspired regimen delivered on an outpatient basis: A single institution experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Etoposide; Humans; Mercaptopurine; Methotrexate; Outpatients; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 2022 |
Methotrexate-Mediated Arachnoiditis in a Child with Acute Lymphoblastic Leukemia
Topics: Arachnoiditis; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Panobinostat (LBH589) increase survival in adult xenografic model of acute lymphoblastic leukemia with t(4;11) but promotes antagonistic effects in combination with MTX and 6MP.
Topics: Adult; Animals; Humans; Mercaptopurine; Methotrexate; Mice; Mice, Inbred NOD; Panobinostat; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
[Clinical characteristics and prognosis of seizures in 75 children with acute lymphoblastic leukemia].
Topics: Adolescent; Brain Diseases; Cerebral Hemorrhage; Child; Electroencephalography; Epilepsy; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies | 2022 |
Subacute methotrexate neurotoxicity in patients with oncohematological disease. A report of 3 cases.
Topics: Antimetabolites, Antineoplastic; Humans; Lymphoma; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Effects of splicing-regulatory polymorphisms in ABCC2, ABCG2, and ABCB1 on methotrexate exposure in Chinese children with acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Child; East Asian People; Genotype; Humans; Methotrexate; Multidrug Resistance-Associated Protein 2; Neoplasm Proteins; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Methotrexate-induced Subacute Encephalopathy That Showed No Abnormalities on Magnetic Resonance Imaging Soon after Symptom Appearance.
Topics: Adult; Brain Diseases; Diffusion Magnetic Resonance Imaging; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2023 |
Escalated doses of methotrexate and L-asparaginase in critically ill children with a concurrent diagnosis of acute lymphoblastic leukemia and appendicitis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Appendicitis; Asparaginase; Child; Critical Illness; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Ethnic-specific predictors of neurotoxicity among patients with pediatric acute lymphoblastic leukemia after high-dose methotrexate.
Topics: Antimetabolites, Antineoplastic; Child; Creatinine; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2023 |
Severe Recurrent Nocturnal Hypoglycemia During Chemotherapy With 6-mercaptopurine in 2 Children With Acute Lymphoblastic Leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Child; Female; Humans; Hypoglycemia; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Acute kidney injury and delayed methotrexate clearance in an adult patient with Philadelphia chromosome-positive acute lymphoblastic leukaemia treated with imatinib.
Topics: Acute Kidney Injury; Adult; Female; Humans; Imatinib Mesylate; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Novel and replicated clinical and genetic risk factors for toxicity from high-dose methotrexate in pediatric acute lymphoblastic leukemia.
Topics: Bayes Theorem; Child; Creatinine; Humans; Liver-Specific Organic Anion Transporter 1; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk Factors | 2023 |
[Applicability of Seven Glomerular Filtration Rate Evaluation Formulas in Dose Adjustment of High Concentration of Methotrexate Chemotherapy in Children with ALL].
Topics: Adolescent; Child; Child, Preschool; Creatinine; Glomerular Filtration Rate; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency, Chronic | 2023 |
Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling.
Topics: Animals; Chemical and Drug Induced Liver Injury; Melatonin; Methotrexate; Phosphatidylinositol 3-Kinases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Rats; TOR Serine-Threonine Kinases | 2023 |
Correlation between methylation level of the
Topics: Adult; Antimetabolites, Antineoplastic; Humans; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein; Retrospective Studies | 2023 |
Effect of two additional doses of intrathecal methotrexate during induction therapy on serious infectious toxicity in pediatric patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Humans; Induction Chemotherapy; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Impact of triple intrathecal prophylaxis in acute lymphoblastic leukemia adults receiving HyperCVAD: A COVID-19 practice change.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; COVID-19; Cyclophosphamide; Humans; Methotrexate; Pandemics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Vincristine | 2023 |
[Correlation between
Topics: Child; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Frequency; Genotype; Humans; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transcription Factors | 2023 |
Population Pharmacokinetic Model of Methotrexate in Brazilian Pediatric Patients with Acute Lymphoblastic Leukemia.
Topics: Antimetabolites, Antineoplastic; Brazil; Child; Humans; Kinetics; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Management of methotrexate and low-dose acetylsalicylic acid interaction in a child with acute lymphoblastic leukemia and moyamoya disease: A case report.
Topics: Aspirin; Child; Humans; Methotrexate; Moyamoya Disease; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Metabolomic profiling reveals the mechanisms underlying the nephrotoxicity of methotrexate in children with acute lymphoblastic leukemia.
Topics: Acute Kidney Injury; Child; Humans; Metabolomics; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Pharmacokinetic-pharmacodynamic modeling of maintenance therapy for childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Humans; Leukocyte Count; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Young Adult | 2023 |
Predicting delayed methotrexate elimination in pediatric acute lymphoblastic leukemia patients: an innovative web-based machine learning tool developed through a multicenter, retrospective analysis.
Topics: Child; Creatinine; Humans; Internet; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2023 |
A semimechanistic pharmacokinetic/pharmacodynamic model for alanine aminotransferase-based hepatotoxicity of methotrexate in paediatric patients with acute lymphoid leukaemia.
Topics: Alanine Transaminase; Chemical and Drug Induced Liver Injury; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2023 |
MicroRNA-411-3p motivates methotrexate's cellular uptake and cytotoxicity via targeting Yin-yang 1 in leukemia cells.
Topics: Biological Transport; Humans; Methotrexate; MicroRNAs; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Yin-Yang | 2023 |
The Expression and Activation of the NF-κB Pathway Correlate with Methotrexate Resistance and Cell Proliferation in Acute Lymphoblastic Leukemia.
Topics: Cell Proliferation; Child; Humans; Immunosuppressive Agents; Methotrexate; NF-kappa B; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Necrosis Factor-alpha | 2023 |
[Characteristics and management of leukoencephalopathy in leukemia treatment].
Topics: Administration, Intravenous; Central Nervous System; Humans; Leukoencephalopathies; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Invasive mucormycosis during treatment for acute lymphoblastic leukaemia-successful management of two life-threatening diseases.
Topics: Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Invasive Fungal Infections; Lung Diseases, Fungal; Male; Mercaptopurine; Methotrexate; Mucorales; Mucormycosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Triazoles; Vincristine | 2020 |
Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antidotes; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Infant; Leucovorin; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Vitamin B 12 | 2019 |
Methotrexate and asparaginase: not so simple.
Topics: Asparaginase; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2019 |
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Child; Child, Preschool; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Transcription Factors; Treatment Outcome; Tumor Cells, Cultured | 2020 |
Serum neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for predicting high dose methotrexate associated acute kidney injury in children with acute lymphoblastic leukemia.
Topics: Acute Kidney Injury; Adolescent; Antimetabolites, Antineoplastic; Biomarkers; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Infant; Lipocalin-2; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; ROC Curve | 2020 |
Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia.
Topics: 5'-Nucleotidase; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Child; DNA Mutational Analysis; Female; Follow-Up Studies; Genomics; High-Throughput Nucleotide Sequencing; Humans; Male; Methotrexate; Mutagenesis; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Receptors, Glucocorticoid; Survival Rate; Tumor Suppressor Protein p53 | 2020 |
Diffuse large B cell lymphoma associated with methotrexate in a patient with acute lymphoblastic leukemia.
Topics: Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Line, Tumor; Glutamic Acid; Humans; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2019 |
Prediction of leukocyte counts during paediatric acute lymphoblastic leukaemia maintenance therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bayes Theorem; Child; Child, Preschool; Datasets as Topic; Drug Dosage Calculations; Female; Humans; Infant; Leukocyte Count; Leukocytes; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Models, Biological; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stochastic Processes | 2019 |
Optimizing the use of the hyperCVAD regimen: Clinical vignettes and practical management.
Topics: Age Factors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Constipation; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Monitoring; Fusion Proteins, bcr-abl; Genetic Predisposition to Disease; Humans; Injections, Spinal; Intercellular Signaling Peptides and Proteins; Kidney; Methotrexate; Ophthalmic Solutions; Peripheral Nervous System Diseases; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Protein-Tyrosine Kinases; Vincristine | 2020 |
Systemic methotrexate absorption in a patient receiving intrathecal chemotherapy for acute lymphoblastic leukemia.
Topics: Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Severe, Fatal Methotrexate-related Neurotoxicity in 2 Adolescent Patients With ALL.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Fatal Outcome; Female; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Severity of Illness Index; Young Adult | 2020 |
Pharmacogenetic Variants in MTHFR Gene are Significant Predictors of Methotrexate Toxicities in Bangladeshi Patients With Acute Lymphoblastic Leukemia.
Topics: Adolescent; Adult; Bangladesh; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenomic Variants; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2020 |
Delayed methotrexate clearance and acute kidney injury after high-dose methotrexate chemotherapy concurrent with dasatinib in a patient with relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia: A case report.
Topics: Acute Kidney Injury; Dasatinib; Humans; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors | 2020 |
Dextromethorphan Administration on Day 0 and Day 7 for Secondary Prevention of Methotrexate-induced Neurotoxicity in Childhood Acute Lymphoblastic Leukemia: A Retrospective Case Series.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Secondary Prevention; Young Adult | 2021 |
Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate.
Topics: Auditory Pathways; Auditory Threshold; Brain Stem; Child; Child, Preschool; Evoked Potentials, Auditory, Brain Stem; Humans; Methotrexate; Otoacoustic Emissions, Spontaneous; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Reduced-dose intensity therapy for pediatric lymphoblastic leukemia: long-term results of the Recife RELLA05 pilot study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Rate; Vincristine | 2020 |
Genetic polymorphism in
Topics: Antimetabolites, Antineoplastic; Asian People; ATP Binding Cassette Transporter, Subfamily B; Child; China; Female; Gene Frequency; Genotype; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Implementation of RNA sequencing and array CGH in the diagnostic workflow of the AIEOP-BFM ALL 2017 trial on acute lymphoblastic leukemia.
Topics: Abnormal Karyotype; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Comparative Genomic Hybridization; Cyclophosphamide; Cytarabine; Daunorubicin; Genes, Neoplasm; Humans; Ikaros Transcription Factor; In Situ Hybridization, Fluorescence; Mercaptopurine; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Risk Factors; RNA, Messenger; RNA, Neoplasm; Sequence Analysis, RNA; Transcriptome; Vincristine; Workflow | 2020 |
Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicity.
Topics: Acetylcysteine; Bone Marrow; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Deferasirox; Drug Resistance, Neoplasm; Female; Ferric Compounds; Free Radical Scavengers; Humans; Infant; Inhibitory Concentration 50; Iron; Iron Chelating Agents; Male; Methotrexate; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-bcl-2; Quaternary Ammonium Compounds; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Transcriptome; Up-Regulation | 2020 |
Isolated Central Nervous System Relapse Following Treatment Reduction in Low-risk Acute Lymphoblastic Leukemia at the Children's Cancer Center of Lebanon.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Central Nervous System Neoplasms; Child; Child, Preschool; Dexamethasone; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Incidence; Infant; Lebanon; Male; Methotrexate; Neoplasm Recurrence, Local; Non-Randomized Controlled Trials as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Survival Rate | 2020 |
T Regulatory Cell Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Etoposide; Female; Humans; Hydrocortisone; Maintenance Chemotherapy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; T-Lymphocytes, Regulatory; Vincristine | 2020 |
Pharmacogenomic Markers of Methotrexate Response in the Consolidation Phase of Pediatric Acute Lymphoblastic Leukemia Treatment.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Gene Expression Regulation, Neoplastic; Genotype; Humans; Infant; Male; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Effects of germline DHFR and FPGS variants on methotrexate metabolism and relapse of leukemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Genome-Wide Association Study; Humans; Infant; Infant, Newborn; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Peptide Synthases; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Tetrahydrofolate Dehydrogenase; Young Adult | 2020 |
Concurrent Imatinib Dosing With High-dose Methotrexate Leads to Acute Kidney Injury and Delayed Methotrexate Clearance in Pediatric Patients With Philadelphia Chromosome-positive B-Cell Acute Lymphoblastic Leukemia.
Topics: Acute Kidney Injury; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Imatinib Mesylate; Leukemia, B-Cell; Male; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Young Adult | 2021 |
Methylation analysis of the SLC19A1 promoter region in Chinese children with acute lymphoblastic leukaemia.
Topics: Antimetabolites, Antineoplastic; Asian People; Child; Female; Humans; Male; Methotrexate; Methylation; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein | 2020 |
High-dose methotrexate-induced fulminant hepatic failure and pancytopenia in an acute lymphoblastic leukaemia paediatric patient.
Topics: Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child, Preschool; Dose-Response Relationship, Drug; Fatal Outcome; Heart Arrest; Humans; Liver Failure, Acute; Male; Methotrexate; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Child; Humans; In Vitro Techniques; Leucovorin; Methotrexate; Mouth Mucosa; Organ Culture Techniques; Organoids; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis | 2020 |
Influence of plasma methotrexate level and MTHFR genotype in Korean paediatric patients with acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Republic of Korea | 2020 |
Association of GGH Promoter Methylation Levels with Methotrexate Concentrations in Chinese Children with Acute Lymphoblastic Leukemia.
Topics: Antimetabolites, Antineoplastic; Asian People; Child; Child, Preschool; China; DNA Methylation; Female; gamma-Glutamyl Hydrolase; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Assessing changes in microstructural integrity of white matter tracts in children with leukaemia following exposure to chemotherapy.
Topics: Anisotropy; Antimetabolites, Antineoplastic; Brain Mapping; Child; Child, Preschool; Diffusion Tensor Imaging; Female; Humans; Image Interpretation, Computer-Assisted; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; White Matter | 2020 |
Hispanic ethnicity is associated with prolonged clearance of high dose methotrexate and severe nephrotoxicity in children and adolescents with acute lymphoblastic leukemia.
Topics: Adolescent; Child; Ethnicity; Hispanic or Latino; Humans; Infant; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency | 2020 |
Do intravenous fluid substitutions influence methotrexate clearance? An unanticipated impact of an intravenous sodium bicarbonate drug shortage.
Topics: Administration, Intravenous; Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Sodium; Sodium Bicarbonate | 2020 |
Interleukin-6-Mediated Inflammation May Cause Methotrexate-Induced Leukoencephalopathy.
Topics: Antimetabolites, Antineoplastic; Child; Humans; Hypertension; Inflammation; Interleukin-6; Leukoencephalopathies; Methotrexate; Posterior Leukoencephalopathy Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Child; Child, Preschool; Down Syndrome; Female; Follow-Up Studies; Humans; Infant; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Rate | 2021 |
Drug-induced aseptic meningitis in a Ph+ ALL patient with meningeal involvement.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Meningitis, Aseptic; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
A second administration of glucarpidase in a different cycle of high-dose methotrexate: Is it safe and effective in adults?
Topics: Acute Kidney Injury; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; gamma-Glutamyl Hydrolase; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Treatment Outcome | 2021 |
SARS-CoV-2 infection in a 7-year-old girl with pancytopenia during acute lymphocytic leukemia maintenance therapy.
Topics: Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antiviral Agents; Austria; Child; COVID-19; COVID-19 Drug Treatment; Female; Humans; Mercaptopurine; Methotrexate; Pancytopenia; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; SARS-CoV-2; Treatment Outcome | 2020 |
Safe administration of high-dose methotrexate with minimal drug level monitoring: Experience from a center in north India.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Female; Follow-Up Studies; Humans; India; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Survival Rate | 2020 |
Oral mucositis in childhood cancer patients receiving high-dose methotrexate: Prevalence, relationship with other toxicities and methotrexate elimination.
Topics: Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Stomatitis | 2021 |
Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia.
Topics: Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Body Surface Area Dosing of High-Dose Methotrexate Should Be Reconsidered, Particularly in Overweight, Adult Patients.
Topics: Acute Kidney Injury; Adult; Antimetabolites, Antineoplastic; Body Surface Area; Humans; Methotrexate; Overweight; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
Effect of SLCO1B1 Polymorphisms on High-Dose Methotrexate Clearance in Children and Young Adults With Leukemia and Lymphoblastic Lymphoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Leukemia, Lymphoid; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Models, Biological; Pharmacogenomic Testing; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2021 |
Repeat-positive SARS-CoV-2 in a child with cancer.
Topics: Antimetabolites, Antineoplastic; Asymptomatic Diseases; Child, Preschool; COVID-19; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; SARS-CoV-2 | 2021 |
An exploration of mercaptopurine/methotrexate tolerance during maintenance therapy in children with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2021 |
Cyclin D1 G870A Polymorphism: Relation to the Risk of ALL Development, Prognosis Impact, and Methotrexate Cytotoxicity.
Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Cyclin D1; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Infant; Liver Function Tests; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Rate | 2020 |
Citrulline as a biomarker of bacteraemia during induction treatment for childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Bacteria; Biomarkers; Child; Child, Preschool; Citrulline; Doxorubicin; Female; Follow-Up Studies; Humans; Induction Chemotherapy; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Retrospective Studies; Vincristine | 2021 |
Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo.
Topics: Adolescent; Cell Line, Tumor; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Neoplasm Proteins; Pharmacogenomic Testing; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Comparison of outcomes of children with acute lymphoblastic leukemia treated with BMF protocol across 2 decades.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tegafur; Time Factors; Treatment Outcome | 2021 |
Effects of thymidylate synthase polymorphisms on toxicities associated with high-dose methotrexate in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Genotype; Humans; Male; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Retrospective Studies; Thymidylate Synthase | 2021 |
Development and Validation of UHPLC-MS/MS Assay for Therapeutic Drug Monitoring of High-dose Methotrexate in Children with Acute Lymphoblastic Leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Calibration; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Methotrexate; Molecular Structure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality Assurance, Health Care; Tandem Mass Spectrometry | 2020 |
Standardized Supportive Care Documentation Improves Safety of High-Dose Methotrexate Treatment.
Topics: Bone Neoplasms; Documentation; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2021 |
Connectivity of the Cerebello-Thalamo-Cortical Pathway in Survivors of Childhood Leukemia Treated With Chemotherapy Only.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cancer Survivors; Case-Control Studies; Cerebellum; Cerebral Cortex; Chemotherapy-Related Cognitive Impairment; Child; Dexamethasone; Executive Function; Female; Functional Neuroimaging; Glucocorticoids; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Methotrexate; Neural Pathways; Neuropsychological Tests; Organ Size; Parietal Lobe; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prefrontal Cortex; Sex Factors; Thalamus; Young Adult | 2020 |
The Application of
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Child; Child, Preschool; China; Female; Glomerular Filtration Rate; Humans; Induction Chemotherapy; Kidney Function Tests; Logistic Models; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; ROC Curve; Technetium Tc 99m Pentetate | 2020 |
Delayed Methotrexate Elimination after Administration of a Medium Dose of Methotrexate in a Patient with Genetic Variants Associated with Methotrexate Clearance.
Topics: Antimetabolites, Antineoplastic; Child; Humans; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Genetic factors involved in delayed methotrexate elimination in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2021 |
Methotrexate-induced Transient Encephalopathy in an Adolescent and Young Adult Patient with Acute Lymphoblastic Leukemia.
Topics: Adolescent; Brain Diseases; Diffusion Magnetic Resonance Imaging; Female; Humans; Methotrexate; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2021 |
Methotrexate-related central neurotoxicity: clinical characteristics, risk factors and genome-wide association study in children treated for acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Australia; Child; Genome-Wide Association Study; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 2022 |
UK paediatric oncology
Topics: Adolescent; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antimetabolites, Antineoplastic; Child; Child, Preschool; Humans; Incidence; Infant; Ireland; Methotrexate; Neoplasms; Pneumocystis carinii; Pneumonia, Pneumocystis; Population Surveillance; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Trimethoprim, Sulfamethoxazole Drug Combination; United Kingdom | 2021 |
New Therapeutic Approach to Reduce Methotrexate Toxicity after High-Dose Chemotherapy in a Child with Acute Lymphocytic Leukemia: Efficacy and Safety of Hemoadsorption with HA-230 Adsorber.
Topics: Antimetabolites, Antineoplastic; Child; Hemoperfusion; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
High-dose methotrexate-induced epidermal necrosis in two pediatric patients.
Topics: Child; Child, Preschool; Female; Humans; Leucovorin; Male; Methotrexate; Necrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Diseases | 2021 |
Safety and Efficacy of Aminophylline in Intrathecal Methotrexate-related Neurological Toxicity in Large Pediatric Oncology Centre.
Topics: Aminophylline; Child; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2021 |
Acute myelopathy during chemotherapy for childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases | 2021 |
Machine learning to predict high-dose methotrexate-related neutropenia and fever in children with B-cell acute lymphoblastic leukemia.
Topics: Artificial Intelligence; B-Lymphocytes; Child; Humans; Machine Learning; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
The Effect of a New Glucose-Methotrexate Conjugate on Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma Cell Lines.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Glucose; Glucose Transport Proteins, Facilitative; Humans; Immunoconjugates; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; DNA; Female; Genotype; Humans; Infant; Male; Mercaptopurine; Methotrexate; Methyltransferases; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2021 |
Methylene tetrahydrofolate reductase A1298C polymorphisms influence the adult sequelae of chemotherapy in childhood-leukemia survivors.
Topics: Adolescent; Adult; Brain; Cancer Survivors; Child; Child, Preschool; Cognition; Diffusion Magnetic Resonance Imaging; Disease Progression; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid Antagonists; Genotype; Humans; Intelligence Tests; Magnetic Resonance Imaging; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rest; Retrospective Studies; tau Proteins; Young Adult | 2021 |
Methotrexate polyglutamate quantification for clinical application in patients with pediatric acute lymphoblastic leukemia in association with genetic polymorphisms.
Topics: Child; Humans; Methotrexate; Polyglutamic Acid; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2021 |
MTHFR 677T-1298C haplotype in acute lymphoblastic leukemia: Impact on methotrexate therapy.
Topics: Genotype; Haplotypes; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Phase-specific risks of outpatient visits, emergency visits, and hospitalizations during Children's Oncology Group-based treatment for childhood acute lymphoblastic leukemia: A population-based study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Dexamethasone; Emergency Service, Hospital; Hospitalization; Humans; Methotrexate; Ontario; Outpatients; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone | 2021 |
Reduced dose folinic acid rescue after rapid high-dose methotrexate clearance is not associated with increased toxicity in a pediatric cohort.
Topics: Acute Disease; Child; Cohort Studies; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2022 |
Severe multiorgan toxicity after first dose of Capizzi methotrexate in a young adult patient with acute lymphocytic leukaemia.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2021 |
Monitoring Of High-Dose Methotrexate (Mtx)-Related Toxicity and Mtx Levels in Children with Acute Lymphoblastic Leukemia: A Pilot-Study in Indonesia.
Topics: Antimetabolites, Antineoplastic; Child; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Indonesia; Infusions, Intravenous; Male; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 2021 |
Association of MTHFR and ABCB1 polymorphisms with MTX-induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma-A retrospective cohort study.
Topics: Adolescent; Asian People; ATP Binding Cassette Transporter, Subfamily B; Child; Child, Preschool; China; Female; Genotype; Humans; Infant; Lymphoma; Lymphoproliferative Disorders; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Osteosarcoma; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2021 |
[A case of acute lymphoblastic leukemia of MTHFR C677T gene positive with methotrexate hypersensitivity was successfully rescued by hemodialysis].
Topics: Antimetabolites, Antineoplastic; Genetic Predisposition to Disease; Genotype; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Dialysis | 2021 |
Efficacy of chemotherapy protocols for hematological malignancies: H-CVAD versus GELA/BURKIMAB/PETHEMA LAL.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Burkitt Lymphoma; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Hematologic Neoplasms; Humans; Lymphoma, Mantle-Cell; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Treatment Outcome; Vincristine; Young Adult | 2021 |
Childhood pre-B cell acute lymphoblastic leukemia with translocation t(1;19)(q21.1;p13.3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report.
Topics: Adolescent; Antimetabolites, Antineoplastic; Chromosome Aberrations; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 16; Doxorubicin; Fatal Outcome; Health Services Accessibility; Humans; Immunophenotyping; Male; Methotrexate; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Syria; Translocation, Genetic; Vincristine | 2017 |
Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients.
Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Female; Gene Frequency; Genotype; Heterozygote; Homozygote; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Mexico; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia.
Topics: Female; Genotype; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2017 |
Prognostic impact of IKZF1 deletions in association with vincristine-dexamethasone pulses during maintenance treatment of childhood acute lymphoblastic leukemia on trial ALL-BFM 95.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Gene Deletion; Humans; Ikaros Transcription Factor; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome; Vincristine | 2017 |
Nausea and vomiting: Therapeutic orphans of pediatric oncology.
Topics: Antiemetics; Child; Child, Preschool; Granisetron; Humans; Methotrexate; Nausea; Ondansetron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serotonin 5-HT3 Receptor Antagonists; Vomiting | 2017 |
Effectiveness of Parenteral Glutamine on Methotrexate-induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Glutamine; Humans; Male; Methotrexate; Parenteral Nutrition; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Stomatitis | 2017 |
The miR-1206 microRNA variant is associated with methotrexate-induced oral mucositis in pediatric acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Gene Frequency; Genetic Association Studies; Humans; Infant; Male; Methotrexate; MicroRNAs; Nucleic Acid Conformation; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Stomatitis | 2017 |
[Effect of GSTP1 and MTHFR Gene Polymorphism on Side Effects of HD-MTX in ALL Children].
Topics: Antimetabolites, Antineoplastic; Child; Gene Frequency; Glutathione S-Transferase pi; Homocystinuria; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2017 |
Effect of polymorphisms in transporter genes on dosing, efficacy and toxicity of maintenance therapy in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; ATP-Binding Cassette Transporters; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Multidrug Resistance-Associated Protein 2; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2017 |
Faecal microbiota transplant: a novel biological approach to extensively drug-resistant organism-related non-relapse mortality.
Topics: Allografts; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacteria; Daunorubicin; Drug Resistance, Bacterial; Fatal Outcome; Fecal Microbiota Transplantation; Feces; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine | 2017 |
Dihydrofolate Reductase Genetic Polymorphisms Affect Methotrexate Dose Requirements in Pediatric Patients With Acute Lymphoblastic Leukemia on Maintenance Therapy.
Topics: Alleles; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Genotype; Haplotypes; Humans; Infant; Infant, Newborn; Maintenance Chemotherapy; Male; Methotrexate; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Tetrahydrofolate Dehydrogenase | 2017 |
Targeted therapy of CNS leukemia?
Topics: Central Nervous System Neoplasms; Combined Modality Therapy; Humans; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2017 |
Effect of methotrexate/vitamin B
Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Methylation; Humans; Long Interspersed Nucleotide Elements; Methotrexate; Neurons; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tacrolimus Binding Proteins; Vitamin B 12 | 2017 |
Posterior reversible encephalopathy syndrome in a postpartum woman with acute lymphoblastic leukaemia after intrathecal methotrexate.
Topics: Antimetabolites, Antineoplastic; Diagnosis, Differential; Female; Humans; Induction Chemotherapy; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Posterior Leukoencephalopathy Syndrome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications, Neoplastic; Young Adult | 2017 |
Evaluation of aprepitant for acute chemotherapy-induced nausea and vomiting in children and adolescents with acute lymphoblastic leukemia receiving high-dose methotrexate.
Topics: Adolescent; Antiemetics; Aprepitant; Child; Female; Humans; Male; Methotrexate; Morpholines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Vomiting | 2018 |
Neurocognitive Functioning in the AALL0232 Protocol.
Topics: Adrenal Cortex Hormones; Child; Cognition Disorders; Humans; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2017 |
[Acute methotrexate-related neurotoxicity and pseudo-stroke syndrome].
Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Child; Diagnosis, Differential; Female; Humans; Leukoencephalopathies; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; Syndrome | 2017 |
DNA variants in DHFR gene and response to treatment in children with childhood B ALL: revisited in AIEOP-BFM protocol.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers, Tumor; Child; Daunorubicin; Disease-Free Survival; DNA; Female; Haplotypes; Humans; Male; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Promoter Regions, Genetic; Tetrahydrofolate Dehydrogenase; Treatment Outcome; Vincristine | 2018 |
A Not Uncommon Cause of Stroke Mimicker in Children.
Topics: Adolescent; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke | 2018 |
Changes in cognition and dendritic complexity following intrathecal methotrexate and cytarabine treatment in a juvenile murine model.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cognition; Cytarabine; Dendrites; Hippocampus; Injections, Spinal; Leukocytes; Male; Methotrexate; Mice, Inbred C57BL; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spatial Memory | 2018 |
Flow cytometric analysis of cerebrospinal fluid in adult patients with acute lymphoblastic leukemia during follow-up.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cytarabine; Dexamethasone; Female; Flow Cytometry; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Analysis; Transplantation, Homologous; Whole-Body Irradiation | 2018 |
Risk factors for impaired pulmonary function and cardiorespiratory fitness in very long-term adult survivors of childhood acute lymphoblastic leukemia after treatment with chemotherapy only
Topics: Adolescent; Adult; Anthracyclines; Antineoplastic Agents; Cardiorespiratory Fitness; Child; Child, Preschool; Cross-Sectional Studies; Cyclophosphamide; Echocardiography; Exercise Test; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Respiratory Function Tests; Respiratory Physiological Phenomena; Risk Factors; Survivors; Vincristine; Young Adult | 2018 |
Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia.
Topics: 3' Untranslated Regions; Adolescent; Alleles; Antimetabolites, Antineoplastic; Asian People; Binding Sites; Child; Child, Preschool; China; Female; Fluorescence Polarization Immunoassay; Humans; Male; Methotrexate; MicroRNAs; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Serum Albumin, Human | 2018 |
Acute and sub-acute neurological toxicity in children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Female; Humans; Infant; Leukoencephalopathies; Male; Methotrexate; Neurotoxicity Syndromes; Polyneuropathies; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Sinus Thrombosis, Intracranial; Treatment Outcome; Vincristine; Vocal Cord Paralysis | 2018 |
MiR-595 Suppresses the Cellular Uptake and Cytotoxic Effects of Methotrexate by Targeting SLC19A1 in CEM/C1 Cells.
Topics: 3' Untranslated Regions; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; MicroRNAs; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2018 |
Anti-leukemic treatment-induced neurotoxicity in long-term survivors of childhood acute lymphoblastic leukemia: impact of reduced central nervous system radiotherapy and intermediate- to high-dose methotrexate.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Brain; Cancer Survivors; Case-Control Studies; Chemoradiotherapy; Child; Cognition Disorders; Cranial Irradiation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Humans; Intelligence Tests; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Organ Size; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Treatment Outcome; Young Adult | 2018 |
Genotype and allele frequencies of TYMS rs2790 A > G polymorphism in a Chinese paediatric population with acute lymphoblastic leukaemia.
Topics: Asian People; Child; Female; Gene Frequency; Genotype; Humans; Male; Methotrexate; MicroRNAs; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase | 2018 |
T-cell-replete haploidentical stem cell transplantation using low-dose antithymocyte globulin in children with relapsed or refractory acute leukemia.
Topics: Adolescent; Antilymphocyte Serum; Child; Child, Preschool; Female; Follow-Up Studies; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Retrospective Studies; Survival Rate; Tacrolimus; Transplantation Conditioning; Treatment Outcome; Young Adult | 2018 |
Evidence of cognitive flexibility deficits and impaired emotion regulation in childhood survivors of acute lymphoblastic leukaemia: Findings from task switching study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cancer Survivors; Case-Control Studies; Child; Cognition; Cognitive Dysfunction; Cytarabine; Emotions; Female; Humans; Hydrocortisone; Infusions, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Self-Control; Task Performance and Analysis | 2018 |
Severe immunodeficiency associated with acute lymphoblastic leukemia and its treatment.
Topics: Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 4; Exanthema; Female; Humans; Immunoglobulins, Intravenous; Immunologic Deficiency Syndromes; Infant, Newborn; Methotrexate; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Translocation, Genetic; Treatment Outcome | 2018 |
Pharmacoepigenetics in childhood acute lymphoblastic leukemia: involvement of miRNA polymorphisms in hepatotoxicity.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genetic Association Studies; Humans; Infant; Liver; Male; Methotrexate; MicroRNAs; Nucleic Acid Conformation; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2018 |
Stevens-Johnson Syndrome associated with methotrexate treatment for acute lymphoblastic leukemia: a case report.
Topics: Antimetabolites, Antineoplastic; Child; Gastrointestinal Hemorrhage; Heart Failure; Humans; Immunoglobulins, Intravenous; Male; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stevens-Johnson Syndrome | 2018 |
ALL relapse with multiple cranial nerve palsies and toxic leukoencephalopathy: treatment failure with treatment toxicity.
Topics: Adult; Cranial Nerve Diseases; Female; Humans; Immunosuppressive Agents; Leukoencephalopathies; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Failure | 2018 |
Neurocognitive Sequelae in Adult Childhood Leukemia Survivors Related to Levels of Phosphorylated Tau.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Biomarkers; Case-Control Studies; Cognition Disorders; Cross-Sectional Studies; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neuropsychological Tests; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Survival Rate; Survivors; tau Proteins; Young Adult | 2017 |
Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; DNA Methylation; Female; Humans; Immunophenotyping; Infant; Long Interspersed Nucleotide Elements; Male; Metabolic Networks and Pathways; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylmethionine; Stomatitis | 2018 |
Outcome of adult T-lymphoblastic lymphoma depends on ALL-type chemotherapy, prognostic factors, and performance of allogeneic hematopoietic stem cell transplantation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Survival Rate; Vincristine; Young Adult | 2018 |
Oral mucositis in paediatric acute lymphoblastic leukemia patients receiving methotrexate-based chemotherapy: case series.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis | 2018 |
Paraneoplastic Demyelinating Sensorimotor Neuropathy Delaying the Diagnosis of an Underlying Acute Lymphoblastic Leukemia in a Child.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain; Child; Daunorubicin; Demyelinating Diseases; Humans; Immunoglobulins, Intravenous; Magnetic Resonance Imaging; Male; Methotrexate; Paraneoplastic Syndromes, Nervous System; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Spine; Tomography, X-Ray Computed; Vincristine | 2018 |
[Spinal subacute combined degeneration after intrathecal chemotherapy. Report of two cases].
Topics: Adolescent; Antimetabolites, Antineoplastic; Cytarabine; Fatal Outcome; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Subacute Combined Degeneration | 2018 |
Intravitreal Methotrexate for Iris and Ciliary Body Relapse in Acute Lymphoblastic Leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Ciliary Body; Female; Humans; Intravitreal Injections; Iris; Leukemic Infiltration; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Slit Lamp Microscopy | 2018 |
Outcomes of Low-Intensity Treatment of Acute Lymphoblastic Leukemia at Butaro Cancer Center of Excellence in Rwanda.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cancer Care Facilities; Child; Cyclophosphamide; Developing Countries; Dexamethasone; Female; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Rwanda; Treatment Outcome; Vincristine | 2018 |
Comparison between Hyper-CVAD and PETHEMA ALL-93 in Adult Acute Lymphoblastic Leukemia: A Single-Center Study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Cyclophosphamide; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Fever; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Treatment Outcome; Vincristine; Young Adult | 2018 |
Methotrexate polyglutamate levels and co-distributions in childhood acute lymphoblastic leukemia maintenance therapy.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Erythrocytes; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2019 |
A mathematical model of white blood cell dynamics during maintenance therapy of childhood acute lymphoblastic leukemia.
Topics: Algorithms; Antimetabolites, Antineoplastic; Child; Drug Therapy, Combination; Humans; Leukocytes; Mercaptopurine; Methotrexate; Models, Theoretical; Outcome Assessment, Health Care; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Secondary Prevention | 2019 |
Renal Function and Plasma Methotrexate Concentrations Predict Toxicities in Adults Receiving High-Dose Methotrexate.
Topics: Adult; Asian People; China; Female; Humans; Kidney; Kidney Function Tests; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency; Retrospective Studies | 2018 |
A Cross-sectional Study of Two Chemotherapy Protocols on Long Term Neurocognitive Functions in Egyptian Children Surviving Acute Lymphoblastic Leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cancer Survivors; Child; Child, Preschool; Cognition; Cross-Sectional Studies; Egypt; Female; Humans; Intelligence Tests; Male; Methotrexate; Neurocognitive Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychometrics; Treatment Outcome | 2018 |
Methotrexate induces astrocyte apoptosis by disrupting folate metabolism in the mouse juvenile central nervous system.
Topics: Animals; Apoptosis; Astrocytes; Caspase 3; Cell Line, Tumor; Central Nervous System; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Methotrexate; Mice; Mice, Inbred C57BL; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Tetrahydrofolate Dehydrogenase | 2019 |
Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease.
Topics: Adult; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Cytarabine; Humans; Hydrocortisone; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2019 |
Methotrexate-induced Acute Myelopathy in a Teenager With High-risk Acute Lymphoblastic Leukemia.
Topics: Adolescent; Ataxia; Female; Humans; Hypesthesia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Population Pharmacokinetic Study and Individual Dose Adjustments of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia or Osteosarcoma.
Topics: Adolescent; Antimetabolites, Antineoplastic; Asian People; Bone Neoplasms; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Young Adult | 2019 |
Modified enzyme multiplied immunoassay technique of methotrexate assay to improve sensitivity and reduce cost.
Topics: Antimetabolites, Antineoplastic; Child; Chromatography, Liquid; Costs and Cost Analysis; Enzyme Multiplied Immunoassay Technique; Humans; Limit of Detection; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Tandem Mass Spectrometry | 2019 |
Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dasatinib; Female; Follow-Up Studies; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Tissue Distribution; Young Adult | 2019 |
Folate pathway genetic polymorphisms modulate methotrexate-induced toxicity in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cross-Sectional Studies; Female; Folic Acid; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Retrospective Studies; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 2019 |
Neurotoxicity more likely in Hispanic children treated for acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Hispanic or Latino; Humans; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2019 |
The Population Pharmacokinetics of High-Dose Methotrexate in Infants with Acute Lymphoblastic Leukemia Highlight the Need for Bedside Individualized Dose Adjustment: A Report from the Children's Oncology Group.
Topics: Antimetabolites, Antineoplastic; Female; Humans; Infant; Male; Methotrexate; Models, Biological; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2019 |
Ex vivo resistance in childhood acute lymphoblastic leukemia: Correlations between BCRP, MRP1, MRP4 and MRP5 ABC transporter expression and intracellular methotrexate polyglutamate accumulation.
Topics: Adolescent; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Child; Child, Preschool; Cytoplasm; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Leukemic; Humans; Infant; Infant, Newborn; Male; Methotrexate; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pilot Projects; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Cell Culture; Tumor Cells, Cultured | 2019 |
Intrathecal dose intensification by CNS status at diagnosis in the treatment of children with acute lymphoblastic leukemia.
Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate | 2019 |
Visualization of Vertebral Body Deformities in Childhood by MRI in a Boy with ALL.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Density; Bone Marrow; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Fractures, Compression; Humans; Image Enhancement; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Spinal Fractures; Spine; Vincristine | 2019 |
Case report on hypersensitivity to methotrexate infusion in a pediatric acute lymphoblastic leukaemia patient.
Topics: Antimetabolites, Antineoplastic; Child; Drug Hypersensitivity; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2020 |
Development and Validation of a Sensitive UHPLC-MS/MS-Based Method for the Analysis of Folylpolyglutamate Synthetase Enzymatic Activity in Peripheral Blood Mononuclear Cells: Application in Rheumatoid Arthritis and Leukemia Patients.
Topics: Arthritis, Rheumatoid; Cell Line, Tumor; Chromatography, High Pressure Liquid; Humans; Leukocytes, Mononuclear; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2019 |
Childhood acute lymphoblastic leukaemia relapse with atypical localised presentation mimicking ankle trauma in a 28-year-old man.
Topics: Adult; Ankle; Diagnosis, Differential; Humans; Leucovorin; Male; Methotrexate; Neoplasm Recurrence, Local; Pain; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed; Vincristine | 2019 |
The effect of asparaginase therapy on methotrexate toxicity and efficacy in children with acute lymphoblastic leukemia.
Topics: Age Factors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2019 |
British OsteoNEcrosis Study (BONES) protocol: a prospective cohort study to examine the natural history of osteonecrosis in older children, teenagers and young adults with acute lymphoblastic leukaemia and lymphoblastic lymphoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Cohort Studies; Dexamethasone; Female; Glucocorticoids; Humans; Lower Extremity; Magnetic Resonance Imaging; Male; Methotrexate; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; United Kingdom; Vincristine; Young Adult | 2019 |
Spinal Cord Toxicity from Intrathecal Chemotherapy: A Case with Clinicopathologic Correlation.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dendritic Cells; Electrodiagnosis; Evoked Potentials, Somatosensory; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Spinal Cord Neoplasms; Treatment Outcome | 2019 |
Influence of genetic factors on long-term treatment related neurocognitive complications, and on anxiety and depression in survivors of childhood acute lymphoblastic leukemia: The Petale study.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Antimetabolites, Antineoplastic; Anxiety; Calcium Channels, L-Type; Child; Child, Preschool; Cohort Studies; Depression; Female; Humans; Infant; Liver-Specific Organic Anion Transporter 1; Long-Term Care; Male; Methotrexate; Neurocognitive Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors; Young Adult | 2019 |
Inotuzumab ozogamicin, a nonchemotherapy option for relapsed acute lymphoblastic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Bispecific; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Cyclophosphamide; Cytarabine; Dexamethasone; Humans; Inotuzumab Ozogamicin; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Salvage Therapy; Vascular Diseases | 2019 |
Ginger extract has anti-leukemia and anti-drug resistant effects on malignant cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cinnamomum zeylanicum; Combined Modality Therapy; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Male; Methotrexate; Phytotherapy; Plant Extracts; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tea; Tumor Cells, Cultured; Young Adult; Zingiber officinale | 2019 |
Impact of Childhood Leukemia Treatment on Attention Measured by the Continuous Performance Test Factor Structure.
Topics: Adolescent; Arizona; Attention; Child; Female; Humans; Longitudinal Studies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Survivors; Texas | 2019 |
Population pharmacokinetic study of delayed methotrexate excretion in children with acute lymphoblastic leukemia
.
Topics: Alanine Transaminase; Alkaline Phosphatase; Antimetabolites, Antineoplastic; Aspartate Aminotransferases; Bilirubin; Child; Creatinine; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2019 |
Methotrexate Polyglutamate Values in Children and Adolescents With Acute Lymphoblastic Leukemia During Maintenance Therapy.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Maintenance Chemotherapy; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Young Adult | 2019 |
Simultaneous Inhibition of Protein Kinase CK2 and Dihydrofolate Reductase Results in Synergistic Effect on Acute Lymphoblastic Leukemia Cells.
Topics: Antineoplastic Agents; Apoptosis; Casein Kinase II; Cell Line, Tumor; Drug Synergism; Folic Acid Antagonists; Humans; Methotrexate; Naphthyridines; Phenazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Tetrahydrofolate Dehydrogenase | 2019 |
Increased methotrexate intolerance in juvenile idiopathic arthritis compared to acute lymphoblastic leukaemia in children.
Topics: Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Parents; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2019 |
Long-term outcomes of modified BFM-95 regimen in adults with newly diagnosed standard-risk acute lymphoblastic leukemia: a retrospective single-center study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asian People; Asparaginase; Cohort Studies; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Retrospective Studies; Risk; Time Factors; Treatment Outcome; Vincristine | 2019 |
Improved Outcome of a Pediatric-Inspired Protocol for High-Risk Adolescent and Young Adult Acute Lymphoblastic Leukemia Patients Using Peg-Asparaginase and Escalating Dose of Methotrexate: Tolerability and Outcome.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Disease-Free Survival; Dose-Response Relationship, Drug; Febrile Neutropenia; Female; Humans; Hyperbilirubinemia; Male; Methotrexate; Outcome Assessment, Health Care; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors; Young Adult | 2019 |
Nasolacrimal system obstruction, ptosis and esotropia due to chemotherapy in acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blepharoptosis; Child; Daunorubicin; Esotropia; Female; Humans; Lacrimal Duct Obstruction; Methotrexate; Nasolacrimal Duct; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine | 2013 |
Risk group assignment differs for children and adults 1-45 yr with acute lymphoblastic leukemia treated by the NOPHO ALL-2008 protocol.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytogenetic Analysis; Dexamethasone; Doxorubicin; Drug Administration Schedule; Female; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Infant; Male; Medication Adherence; Methotrexate; Middle Aged; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Registries; Treatment Outcome; Vincristine; Young Adult | 2013 |
[Kaposiform haemangioendothelioma associated with B-cell acute lymphoblastic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Biopsy; Combined Modality Therapy; Cord Blood Stem Cell Transplantation; Cyclophosphamide; Cytarabine; Diagnostic Errors; Hemangioendothelioma; Hemangioma; Humans; Infant, Newborn; Kasabach-Merritt Syndrome; Leukemia, B-Cell; Male; Mercaptopurine; Methotrexate; Neoplasms, Multiple Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Skin Neoplasms; Transplantation, Homologous | 2013 |
Outcome of patients with acute lymphoblastic leukemia (ALL) following induction therapy with a modified (pulsed dexamethasone rather than continuous prednisone) UKALL XII/ECOG E2993 protocol at Tawam Hospital, United Arab Emirates (UAE).
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cancer Care Facilities; Daunorubicin; Dexamethasone; Female; Humans; Induction Chemotherapy; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Pulse Therapy, Drug; Retrospective Studies; Treatment Outcome; United Arab Emirates; Vincristine; Young Adult | 2013 |
[Relationship between the methylenetetrahydrofolate reductase gene polymorphism and adverse reactions of high-dose methotrexate in children with acute lymphocytic leukemia].
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction | 2013 |
Acral erythema worsened by intravenous infusions of cyclosporin.
Topics: Adult; Antineoplastic Agents; Cyclosporine; Cytarabine; Drug Eruptions; Erythema; Graft vs Host Disease; Humans; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Effects of early chemotherapeutic treatment on learning in adolescent mice: implications for cognitive impairment and remediation in childhood cancer survivors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cognitive Dysfunction; Cytarabine; Female; Humans; Learning; Male; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Survivors | 2013 |
[Re-induction therapy of relapsed Ph(+) acute lymphoblastic leukemia with T315I mutation by HA regimen in combination with HD-MTX regimen].
Topics: Antineoplastic Combined Chemotherapy Protocols; Humans; Male; Methotrexate; Middle Aged; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
The management of hyperleukocytosis in an adult patient with acute lymphoblastic leukemia and ataxia-telangiectasia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Ataxia Telangiectasia; Doxorubicin; Flow Cytometry; Humans; Leucovorin; Leukapheresis; Leukocytosis; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Steroids; Vincristine | 2013 |
Methotrexate-induced myelopathy mimicking subacute combined degeneration of the spinal cord.
Topics: Adult; Antimetabolites, Antineoplastic; Diagnosis, Differential; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Subacute Combined Degeneration | 2013 |
Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Child; Child, Preschool; Cohort Studies; Female; Follow-Up Studies; Germ-Line Mutation; Humans; Infant; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Staging; Neoplasm, Residual; Organic Anion Transporters; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Stomatitis; Survival Rate; Thymidylate Synthase; Tissue Distribution; Treatment Outcome | 2013 |
Can SLC19A1 80G>A polymorphisms predict risk of extremely delayed MTX excretion after high dose of methotrexate?
Topics: Child; Genotype; Humans; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2013 |
Key treatment questions in childhood acute lymphoblastic leukemia: results in 5 consecutive trials performed by the ALL-BFM study group from 1981 to 2000.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Europe; Germany; History, 20th Century; History, 21st Century; Humans; Medical Oncology; Mercaptopurine; Methotrexate; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Randomized Controlled Trials as Topic; Vincristine | 2013 |
ALL-REZ BFM--the consecutive trials for children with relapsed acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Europe; Hematopoietic Stem Cell Transplantation; Humans; Mercaptopurine; Methotrexate; Multicenter Studies as Topic; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Randomized Controlled Trials as Topic; Recurrence; Remission Induction; Retreatment; Survival Rate; Vincristine | 2013 |
Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cyclin B; Cyclin E; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gene Knockdown Techniques; HCT116 Cells; Humans; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2013 |
Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments.
Topics: Algorithms; Antidotes; Antimetabolites; Dose-Response Relationship, Drug; Drug Delivery Systems; Fluorescence Polarization Immunoassay; Gastrointestinal Diseases; Humans; Injections, Spinal; Leucovorin; Methotrexate; Models, Biological; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Temporal lobe epilepsy with hippocampal sclerosis in acute lymphoblastic leukemia.
Topics: Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Diagnosis, Differential; Drug Administration Schedule; Electroencephalography; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; Female; Follow-Up Studies; Hippocampus; Humans; Image Interpretation, Computer-Assisted; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sclerosis | 2013 |
Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Female; Flow Cytometry; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoglobulin Heavy Chains; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Pyrimidines; Real-Time Polymerase Chain Reaction; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Thiazoles; Vincristine; Young Adult | 2013 |
[Experimental study of remaxol as a drug for supportive therapy in traditional and high-dose treatment of tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Etoposide; Gemcitabine; Methotrexate; Mice; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Succinates | 2013 |
F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers; Child; Child, Preschool; Dose-Response Relationship, Drug; F2-Isoprostanes; Female; Humans; Male; Methotrexate; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
A validated LC-MS/MS method for rapid determination of methotrexate in human saliva and its application to an excretion evaluation study.
Topics: Adult; Antimetabolites, Antineoplastic; Chromatography, Liquid; Drug Stability; Female; Humans; Limit of Detection; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Saliva; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cytidine; DNA Modification Methylases; Drug Antagonism; Drug Resistance, Neoplasm; Drug Synergism; Humans; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Aryl Hydrocarbon; Vincristine | 2014 |
An importance of identification of double variant methylenetetrahydrofolate reductase gene C677T and A1298C in cis configuration for pharmacogenetic studies.
Topics: Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2013 |
Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity.
Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Homocysteine; Humans; Liver Function Tests; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S-Adenosylhomocysteine | 2014 |
Serum creatinine and creatinine clearance for predicting plasma methotrexate concentrations after high-dose methotrexate chemotherapy for the treatment for childhood lymphoblastic malignancies.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Creatinine; Female; Humans; Lymphoma, Non-Hodgkin; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Herpes simplex virus reactivation and disease during treatment for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Encephalitis, Herpes Simplex; Fatal Outcome; Female; Hematopoietic Stem Cell Transplantation; Herpes Simplex; Humans; Induction Chemotherapy; Infant; Male; Mercaptopurine; Methotrexate; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Simplexvirus; Stomatitis, Herpetic; Vincristine; Virus Activation | 2014 |
Creatinine clearance rate and serum creatinine concentration are related to delayed methotrexate elimination in children with lymphoblastic malignancies.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Creatinine; Female; Humans; Lymphoma, Non-Hodgkin; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic leukemia and its interaction with MTHFR C677T and A1298C polymorphisms.
Topics: Alleles; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Epistasis, Genetic; Female; Gene Frequency; Genetic Predisposition to Disease; Greece; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2014 |
Influence of pre-hydration and pharmacogenetics on plasma methotrexate concentration and renal dysfunction following high-dose methotrexate therapy.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Kidney; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multidrug Resistance-Associated Protein 2; Odds Ratio; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2013 |
Low-level laser in prevention and treatment of oral mucositis in pediatric patients with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Humans; Infant; Low-Level Light Therapy; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Treatment Outcome | 2013 |
Dexamethasone, methotrexate, ifosfamide, L-asparaginase and etoposide (SMILE) chemotherapy for relapsed or refractory adult lymphoblastic lymphoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Etoposide; Humans; Ifosfamide; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2014 |
Comparison of long-term outcome between white and Vietnamese children treated for acute lymphoblastic leukemia according to the FRALLE 2000 protocol.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asian People; Belgium; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Treatment Outcome; Vietnam; White People; Young Adult | 2014 |
Neurocognitive and neuroradiologic central nervous system late effects in children treated on Pediatric Oncology Group (POG) P9605 (standard risk) and P9201 (lesser risk) acute lymphoblastic leukemia protocols (ACCL0131): a methotrexate consequence? A rep
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cognition Disorders; Female; Humans; Infant; Intelligence Tests; Leukoencephalopathies; Magnetic Resonance Imaging; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Risk Factors; Treatment Outcome | 2014 |
50 years ago in the Journal of Pediatrics: central nervous system complications of children with acute leukemia: an evaluation of treatment methods.
Topics: Central Nervous System Diseases; Child; Evaluation Studies as Topic; History, 20th Century; Humans; Injections, Spinal; Methotrexate; Periodicals as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; United States | 2014 |
Use of allopurinol in children with acute lymphoblastic leukemia to reduce skewed thiopurine metabolism.
Topics: Adolescent; Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Evaluation; Female; Guanine Nucleotides; Humans; Hyperbilirubinemia; Hypoxanthine Phosphoribosyltransferase; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Xanthine Oxidase | 2014 |
Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: influence on cure rates and risk of second cancer.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cohort Studies; Cytogenetic Analysis; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Genotype; Humans; Infant; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Pharmacogenetics; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Risk Factors | 2014 |
Association of ABCC2 -24C>T polymorphism with high-dose methotrexate plasma concentrations and toxicities in childhood acute lymphoblastic leukemia.
Topics: Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Infant; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
High relapse rate of T cell acute lymphoblastic leukemia in adults treated with Hyper-CVAD chemotherapy in Sweden.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Betamethasone; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Survival Analysis; Sweden; Transplantation, Homologous; Vincristine | 2014 |
[Single institution experience of HLA-haploidentical hematopoietic stem cell transplantation for children: current problems and perspective].
Topics: Adolescent; Child; Child, Preschool; Female; Graft vs Host Disease; Haploidy; Hematopoietic Stem Cell Transplantation; Histocompatibility; HLA Antigens; Humans; Immunosuppressive Agents; Infant; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Survival Rate; Tacrolimus; Transplantation Conditioning | 2014 |
Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Germ-Line Mutation; Humans; Leucovorin; Leukoencephalopathies; Logistic Models; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors | 2014 |
Association of -24CT, 1249GA, and 3972CT ABCC2 gene polymorphisms with methotrexate serum levels and toxic side effects in children with acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Female; Genotype; Humans; Infant; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Inadequate folinic acid rescue after methotrexate causing neurocognitive and neuroradiological central nervous system late effects in children with acute lymphatic leukemia.
Topics: Cognition Disorders; Female; Humans; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
In reply.
Topics: Cognition Disorders; Female; Humans; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 1: methotrexate.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Computer Simulation; Humans; Infant; Infant, Newborn; Methotrexate; Models, Biological; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Values; Tissue Distribution; Young Adult | 2014 |
Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children. Part 2: 6-mercaptopurine and its interaction with methotrexate.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Computer Simulation; Drug Interactions; Humans; Infant; Infant, Newborn; Mercaptopurine; Methotrexate; Models, Biological; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tissue Distribution; Young Adult | 2014 |
Associations of novel genetic variations in the folate-related and ARID5B genes with the pharmacokinetics and toxicity of high-dose methotrexate in paediatric acute lymphoblastic leukaemia.
Topics: Adolescent; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; DNA-Binding Proteins; Female; Folic Acid; Gene Frequency; Genetic Variation; Genotype; Humans; Infant; Male; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transcription Factors | 2014 |
High-dose methotrexate in Egyptian pediatric acute lymphoblastic leukemia: the impact of ABCG2 C421A genetic polymorphism on plasma levels, what is next?
Topics: Adolescent; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Child; Child, Preschool; Egypt; Female; Genetic Association Studies; Humans; Infant; Male; Methotrexate; Neoplasm Proteins; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tissue Distribution | 2014 |
Methotrexate pharmacology in leukaemia cells -letter to the editor.
Topics: Child; Drug Resistance, Neoplasm; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 2013 |
[Correlation analysis of FPGS rs10760502G>a polymorphism with prognosis and MTX-related toxicity in pediatric B-cell acute lymphoblastic leukemia].
Topics: Adolescent; Child; Child, Preschool; Female; Genotype; Humans; Infant; Leukemia, B-Cell; Male; Methotrexate; Peptide Synthases; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2014 |
Viral-associated trichodysplasia secondary to antineoplastic treatment in a patient with lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Hair Diseases; Humans; Ichthyosis; Immunocompromised Host; Male; Mercaptopurine; Methotrexate; Polyomavirus Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.
Topics: Adolescent; Asian People; Child; Child, Preschool; DNA; Female; Follow-Up Studies; gamma-Glutamyl Hydrolase; Humans; Immunoenzyme Techniques; Infant; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Peptide Synthases; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2014 |
Effects of a microRNA binding site polymorphism in SLC19A1 on methotrexate concentrations in Chinese children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Asian People; Binding Sites; Child; Child, Preschool; Female; Gene Frequency; Humans; Infant; Male; Methotrexate; MicroRNAs; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2014 |
[Methotrexate toxicity during acute leukemia lymphoblastic].
Topics: Antimetabolites, Antineoplastic; Cheilitis; Female; Humans; Methotrexate; Oral Ulcer; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2014 |
Prescriptions for a toxic combination: use of methotrexate plus trimethoprim-sulfamethoxazole in the United States.
Topics: Adult; Aged; Ambulatory Care; Anti-Infective Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Health Care Surveys; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Pancytopenia; Practice Patterns, Physicians'; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prescriptions; Risk Assessment; Risk Factors; Trimethoprim, Sulfamethoxazole Drug Combination; United States | 2014 |
Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Child, Preschool; Female; Genotype; Humans; Infant; Lebanon; Liver-Specific Organic Anion Transporter 1; Male; Mercaptopurine; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Retrospective Studies; Treatment Outcome | 2014 |
Epidural blood patch in leukemia patient: a case report.
Topics: Antimetabolites, Antineoplastic; Blood Patch, Epidural; Flow Cytometry; Humans; Injections, Spinal; Male; Methotrexate; Middle Aged; Post-Dural Puncture Headache; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Augmented Berlin-Frankfurt-Münster therapy in adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL).
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cohort Studies; Consolidation Chemotherapy; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Female; Humans; Induction Chemotherapy; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Thioguanine; Treatment Outcome; Vincristine; Young Adult | 2014 |
Cure rates of childhood acute lymphoblastic leukemia in Lithuania and the benefit of joining international treatment protocol.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Incidence; Lithuania; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome; Young Adult | 2014 |
Impact of SLCO1B1 521T > C variant on leucovorin rescue and risk of relapse in childhood acute lymphoblastic leukemia treated with high-dose methotrexate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Genotype; Humans; Leucovorin; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Organic Anion Transporters; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Risk Factors | 2014 |
Prognostic factors in adolescent and adult patients with acute lymphoblastic leukemia with two protocols of chemotherapy: a cross-sectional study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Consolidation Chemotherapy; Cross-Sectional Studies; Cyclophosphamide; Cytarabine; Female; Humans; Induction Chemotherapy; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Retrospective Studies; Treatment Outcome; Vincristine; Young Adult | 2015 |
Assessment of renal function during high-dose methotrexate treatment in children with acute lymphoblastic leukemia.
Topics: Acute-Phase Proteins; Adolescent; Antimetabolites, Antineoplastic; beta 2-Microglobulin; Biomarkers; Child; Child, Preschool; Creatinine; Cystatin C; Dose-Response Relationship, Drug; Feasibility Studies; Female; Follow-Up Studies; Humans; Kidney Function Tests; Lipocalin-2; Lipocalins; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Proto-Oncogene Proteins | 2014 |
Medication errors on oral chemotherapy in children with acute lymphoblastic leukemia in a developing country.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cross-Sectional Studies; Developing Countries; Dexamethasone; Drug Prescriptions; Female; Follow-Up Studies; Humans; Infant; Male; Medication Errors; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies | 2014 |
SLC19A1 hot spot for MTX plasma concentration.
Topics: Female; Humans; Male; Methotrexate; MicroRNAs; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2014 |
Idiopathic Hyperammonemia That Developed During Initial Treatment With Steroid in a Patient With Newly Diagnosed Leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Hydrocortisone; Hyperammonemia; Lactulose; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis | 2015 |
Are concerns about folic acid supplementation in children with acute lymphoblastic leukemia justified?
Topics: Antineoplastic Agents; Drug Interactions; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2014 |
Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Asian People; Female; Genotype; Hematologic Neoplasms; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Young Adult | 2014 |
[Adolescent and young adult Philadelphia negative B cell acute lymphoblastic leukemia: results of the Chilean protocol LLA 15-30].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cohort Studies; Dexamethasone; Female; Humans; Male; Methotrexate; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Treatment Outcome; Vincristine; Young Adult | 2014 |
Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heterozygote; Humans; Leukopenia; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Myelopoiesis; Nucleic Acid Synthesis Inhibitors; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk; Scandinavian and Nordic Countries; Survival Analysis | 2015 |
Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Erythrocytes; Female; Folic Acid; Genotype; Humans; Infant; Male; Methotrexate; Mucositis; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 2015 |
Severe neurotoxicity following intrathecal methotrexate with nitrous oxide sedation in a child with acute lymphoblastic leukemia.
Topics: Analgesics, Non-Narcotic; Child; Female; Humans; Immunosuppressive Agents; Injections, Spinal; Intracranial Hemorrhages; Methotrexate; Neurotoxicity Syndromes; Nitrous Oxide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography | 2015 |
Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS).
Topics: Animals; Antimetabolites, Antineoplastic; Astrocytes; Blood Proteins; c-Mer Tyrosine Kinase; Case-Control Studies; Cell Survival; Central Nervous System; Child; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Coculture Techniques; Female; Galectin 3; Galectins; Gene Expression Regulation, Leukemic; Glioma; Humans; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Cell Culture; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Receptor Protein-Tyrosine Kinases; RNA, Small Interfering; Signal Transduction; Translocation, Genetic; Tumor Cells, Cultured | 2015 |
A simple but very important missing point about intrathecal chemotherapy.
Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.
Topics: Animals; Antineoplastic Agents; Biopsy; Clone Cells; Cytarabine; Deoxycytidine Kinase; Dexamethasone; Disease Progression; DNA, Neoplasm; Drug Resistance, Neoplasm; Female; Gene Dosage; Heterografts; Humans; Male; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Neoplasm Proteins; Neoplasm Transplantation; Neoplastic Stem Cells; Peptide Synthases; Polymorphism, Single Nucleotide; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Radiation Chimera; Sequence Analysis, DNA; Vincristine | 2015 |
Superior outcome using cyclosporin A alone versus cyclosporin A plus methotrexate for post-transplant immunosuppression in children with acute leukemia undergoing sibling hematopoietic stem cell transplantation.
Topics: Adolescent; Child; Child, Preschool; Cyclosporine; Disease-Free Survival; Female; Germany; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Infant; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Prevention; Retrospective Studies; Severity of Illness Index; Siblings; Treatment Outcome; Young Adult | 2015 |
Acute encephalomyelitis complicated with severe neurological sequelae after intrathecal administration of methotrexate in a patient with acute lymphoblastic leukemia.
Topics: Acute Disease; Brain; Child, Preschool; Diffusion Magnetic Resonance Imaging; Encephalomyelitis; Female; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Severity of Illness Index; Spinal Cord | 2014 |
[SLCO1B1c. 521T>C gene polymorphisms are associated with high-dose methotrexate pharmacokinetics and clinical outcome of pediatric acute lymphoblastic leukemia].
Topics: Alleles; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Daunorubicin; Disease-Free Survival; Genotype; Humans; Leucovorin; Liver-Specific Organic Anion Transporter 1; Methotrexate; Organic Anion Transporters; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Treatment Outcome; Vincristine | 2014 |
A novel mechanism of toxic injury to the Papez circuit from chemotherapy.
Topics: Adolescent; Brain; Cytarabine; Drug Delivery Systems; Humans; Magnetic Resonance Imaging; Memory Disorders; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2015 |
Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia.
Topics: Acute Disease; Adolescent; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Denmark; Genotype; Haplotypes; Humans; Infant; Male; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Recurrence; Risk Assessment; Treatment Outcome | 2015 |
Mycophenolate-based graft versus host disease prophylaxis is not inferior to methotrexate in myeloablative-related donor stem cell transplantation.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Cyclosporine; Cytomegalovirus; Cytomegalovirus Infections; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Myeloablative Agonists; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Survival Analysis; Tissue Donors; Transplantation Conditioning; Transplantation, Homologous | 2015 |
[Influence of thymidylate synthase gene polymorphisms on high-dose methotrexate-related toxicities in childhood acute lymphoblastic leukemia].
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Infant; Male; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase | 2015 |
[Dasatinib-related pneumonia? An example of pharmacovigilance survey].
Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Middle Aged; Pharmacovigilance; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recombinant Proteins; Thiazoles; Tomography, X-Ray Computed; Vincristine | 2015 |
Myelopathy following intrathecal chemotherapy in adults: a single institution experience.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Cytarabine; Female; Humans; Injections, Spinal; Leukemia, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Myelin Basic Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord; Spinal Cord Diseases | 2015 |
Mercaptopurine metabolite levels are predictors of bone marrow toxicity following high-dose methotrexate therapy of childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythrocytes; Female; Guanine Nucleotides; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Thrombocytopenia | 2015 |
Toxicity profile and treatment delays in NOPHO ALL2008-comparing adults and children with Philadelphia chromosome-negative acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Male; Methotrexate; Middle Aged; Osteonecrosis; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Thrombosis; Treatment Outcome; Vincristine | 2016 |
Survival of Mexican Children with Acute Lymphoblastic Leukaemia under Treatment with the Protocol from the Dana-Farber Cancer Institute 00-01.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Mexico; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Treatment Outcome; United States; Vincristine | 2015 |
Clinical Course of Cerebral Venous Thrombosis in Adult Acute Lymphoblastic Leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cerebrovascular Disorders; Clinical Trials, Phase II as Topic; Drug Administration Schedule; Female; Headache; Humans; Injections, Spinal; Male; Methotrexate; Middle Aged; Netherlands; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Retrospective Studies; Risk Factors; Seizures; Spinal Puncture; Time Factors; Venous Thromboembolism; Venous Thrombosis; Young Adult | 2015 |
Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Child; Drug Resistance, Neoplasm; Female; Humans; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2015 |
Treatment of young children with CNS-positive acute lymphoblastic leukemia without cranial radiotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child, Preschool; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate | 2015 |
Does genetic susceptibility increase risk for neurocognitive decline among patients with acute lymphoblastic leukemia?
Topics: Economics, Pharmaceutical; Genetic Predisposition to Disease; Humans; Methotrexate; Neurocognitive Disorders; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 2015 |
Evaluating Intestinal Permeability by Measuring Plasma Endotoxin and Diamine Oxidase in Children with Acute Lymphoblastic Leukemia Treated with High-dose Methotrexate.
Topics: Amine Oxidase (Copper-Containing); Antimetabolites, Antineoplastic; Child; Endotoxins; Humans; Infant; Intestinal Mucosa; Limulus Test; Methotrexate; Permeability; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spectrophotometry; Survival Rate | 2016 |
Evaluation of serum and urine fetuin-A levels in children with acute lymphoblastic leukemia during and after high-dose methotrexate therapy: Relation to toxicity.
Topics: Adolescent; alpha-2-HS-Glycoprotein; Child; Child, Preschool; Female; Humans; Infant; Kidney Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
Is a New Protocol for Acute Lymphoblastic Leukemia Research or Standard Therapy?
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Clinical Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Evidence-Based Medicine; Humans; Leucovorin; Mercaptopurine; Methotrexate; Netherlands; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Assessment; Therapeutic Human Experimentation; United States; Vincristine | 2015 |
Influence of dihydrofolate reductase gene polymorphisms rs408626 (-317A>G) and rs442767 (-680C>A) on the outcome of methotrexate-based maintenance therapy in South Indian patients with acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genotype; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Treatment Outcome; White People; Young Adult | 2015 |
Association of ABCB1, ABCC5 and xanthine oxidase genetic polymorphisms with methotrexate adverse reactions in Mexican pediatric patients with ALL.
Topics: Adolescent; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Cancer Care Facilities; Child; Child, Preschool; Female; Genetic Association Studies; Humans; Maintenance Chemotherapy; Male; Methotrexate; Mexico; Multidrug Resistance-Associated Proteins; Myelopoiesis; Pharmacovigilance; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Xanthine Oxidase | 2015 |
Persistent and Prolonged Parvovirus B19 Viremia in a Pediatric Patient With Acute Lymphoblastic Leukemia.
Topics: Antineoplastic Agents; Asymptomatic Infections; Child; Humans; Immunocompromised Host; Immunoglobulins, Intravenous; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Parvoviridae Infections; Parvovirus B19, Human; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Viremia | 2015 |
TPMT gene expression is increased during maintenance therapy in childhood acute lymphoblastic leukemia patients in a TPMT gene promoter variable number of tandem repeat-dependent manner.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow; Child; Child, Preschool; Female; Gene Expression Regulation, Neoplastic; Humans; Infant; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Minisatellite Repeats; Monocytes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic | 2015 |
Impact of therapy in a cohort of unselected children with Down Syndrome-associated Acute Lymphoblastic Leukaemia.
Topics: Anthracyclines; Child; Child, Preschool; Cohort Studies; Down Syndrome; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Treatment Outcome | 2016 |
Patients' Adherence in the Maintenance Therapy of Children and Adolescents with Acute Lymphoblastic Leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Female; Food-Drug Interactions; Humans; Infant; Maintenance Chemotherapy; Male; Medication Adherence; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Surveys and Questionnaires | 2015 |
Functional variants of gene encoding folate metabolizing enzyme and methotrexate-related toxicity in children with acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Gene Frequency; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2015 |
Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.
Topics: Adult; Alternative Splicing; Antineoplastic Agents; Blotting, Western; Child; Drug Resistance, Neoplasm; Female; Flow Cytometry; Humans; Male; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2016 |
Serum Creatinine Versus Plasma Methotrexate Levels to Predict Toxicities in Children Receiving High-dose Methotrexate.
Topics: Adolescent; Child; Child, Preschool; Creatinine; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2015 |
CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia.
Topics: Alleles; Amino Acid Substitution; Child; Child, Preschool; Cyclin D1; Drug Resistance, Neoplasm; Female; Genotype; Humans; Liver; Male; Methotrexate; Mutation; Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2015 |
Extreme Spindles and Leukoencephalopathy after Acute Lymphoblastic Leukemia Treatment: An Undescribed Association.
Topics: Child, Preschool; Diagnosis, Differential; Electroencephalography; Humans; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2015 |
[Clinical and Prognostic analysis of 43 Children with Mature B-cell Non-Hodgkin's Lymphoma/Acute Lymphoblastic Leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Cyclophosphamide; Cytarabine; Disease-Free Survival; Doxorubicin; Etoposide; Female; Humans; Hydrocortisone; Leucovorin; Logistic Models; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Multivariate Analysis; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Retrospective Studies; Survival Rate; Vincristine | 2016 |
The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Male; Methotrexate; Neoplasm Proteins; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA Splicing; Survival Rate | 2016 |
Alternating hemiparesis and orolingual apraxia as manifestations of methotrexate neurotoxicity in a paediatric case of acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Apraxias; Brain; Female; Humans; Injections, Spinal; Methotrexate; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
Concomitant Presentation of Hemophagocytic Lymphohistiocytosis and Posttransplant Lymphoproliferative Disease-Like Lymphoma in a Mildly Immunosuppressed Leukemia Patient: An Unusual Association.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cyclosporine; Dexamethasone; Epstein-Barr Virus Infections; Etoposide; Female; Humans; Immunocompromised Host; Infant; Lymphohistiocytosis, Hemophagocytic; Male; Mercaptopurine; Methotrexate; Multiple Organ Failure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rituximab; Treatment Failure; Vincristine; Viral Load | 2016 |
Association Between Combined Presence of Hepatitis C Virus and Polymorphisms in Different Genes With Toxicities of Methotrexate and 6-Mercaptopurine in Children With Acute Lymphoblastic Leukemia.
Topics: Child; Child, Preschool; Female; Genotype; Hepacivirus; Humans; Liver; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
Impact of complete molecular response on survival in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Female; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Infant; Male; Methotrexate; Neoplasm, Residual; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Vincristine | 2016 |
Intracranial Hemorrhage Following Intrathecal Methotrexate Therapy for Acute Lymphoblastic Leukaemia.
Topics: Antineoplastic Agents; Brain; Child, Preschool; Female; Humans; Injections, Spinal; Intracranial Hemorrhages; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
Chemotherapy Pharmacodynamics and Neuroimaging and Neurocognitive Outcomes in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia.
Topics: Adolescent; Child; Executive Function; Female; Frontal Lobe; Humans; Intelligence; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Male; Methotrexate; Neuroimaging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prefrontal Cortex; Treatment Outcome | 2016 |
Wernicke's encephalopathy in a child with Down syndrome, undergoing treatment for acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Brain; Child; Down Syndrome; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Wernicke Encephalopathy | 2016 |
Measures of 6-mercaptopurine and methotrexate maintenance therapy intensity in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Aging; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Child; Child, Preschool; Female; Genotype; Humans; Leukocyte Count; Leukopenia; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; PTEN Phosphohydrolase; Risk Assessment | 2016 |
MiR-pharmacogenetics of methotrexate in childhood B-cell acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Male; Methotrexate; MicroRNAs; Organic Anion Transporters; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein; Retrospective Studies; Spain; White People | 2016 |
Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.
Topics: Base Sequence; Cell Line, Tumor; Clonal Evolution; Drug Resistance, Neoplasm; Genes, ras; Humans; Methotrexate; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2016 |
Leukoencephalopathy and long-term neurobehavioural, neurocognitive, and brain imaging outcomes in survivors of childhood acute lymphoblastic leukaemia treated with chemotherapy: a longitudinal analysis.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Behavior Rating Scale; Child; Child Behavior Disorders; Cognition Disorders; Cranial Irradiation; Dexamethasone; Diffusion Tensor Imaging; Female; Humans; Injections, Spinal; Intelligence Tests; Leukoencephalopathies; Longitudinal Studies; Magnetic Resonance Imaging; Male; Memory, Short-Term; Methotrexate; Neuropsychological Tests; Observational Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Survivors; Treatment Outcome; White Matter | 2016 |
Development and validation of LC-MS/MS assay for the simultaneous determination of methotrexate, 6-mercaptopurine and its active metabolite 6-thioguanine in plasma of children with acute lymphoblastic leukemia: Correlation with genetic polymorphism.
Topics: Antimetabolites, Antineoplastic; Child; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Mercaptopurine; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Solid Phase Extraction; Tandem Mass Spectrometry; Thioguanine | 2016 |
Using a Bedside Algorithm to Individually Dose High-dose Methotrexate for Patients at Risk for Toxicity.
Topics: Acute Kidney Injury; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Fluid Therapy; Humans; Infusions, Intravenous; Methotrexate; Mucositis; Nervous System Diseases; Point-of-Care Systems; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2017 |
Drug-resistant epilepsy after treatment for childhood acute lymphocytic leukaemia: from focal epilepsy to Lennox-Gastaut syndrome.
Topics: Antimetabolites, Antineoplastic; Cranial Irradiation; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Humans; Lennox Gastaut Syndrome; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2016 |
Exploratory research for optimal GvHD prophylaxis after single unit CBT in adults: short-term methotrexate reduced the incidence of severe GvHD more than mycophenolate mofetil.
Topics: Adolescent; Adult; Cord Blood Stem Cell Transplantation; Cyclosporine; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Incidence; Japan; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Registries; Survival Rate; Tacrolimus | 2017 |
Graft-Versus-Host Disease in Adolescents and Young Adults (15-24 Years Old) After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Leukemia in First Complete Remission.
Topics: Acute Disease; Adolescent; Adult; Child; Chronic Disease; Cyclosporine; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Incidence; Intestinal Diseases; Leukemia, Myeloid, Acute; Methotrexate; Mortality; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Quality of Life; Remission Induction; Severity of Illness Index; Skin Diseases; Survival Rate; Transplantation, Homologous; Young Adult | 2017 |
Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia.
Topics: Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Gene Frequency; Humans; Male; Methotrexate; Peptide Synthases; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2016 |
The Conundrum in the Diagnosis and Management of Atypical Fulminant Measles in a Leukemia Survivor on Maintenance Chemotherapy.
Topics: Adrenal Cortex Hormones; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Cryptogenic Organizing Pneumonia; Diagnostic Errors; Extracorporeal Membrane Oxygenation; Fatal Outcome; Humans; Lymphohistiocytosis, Hemophagocytic; Maintenance Chemotherapy; Male; Measles; Mercaptopurine; Methotrexate; Multiple Organ Failure; Pancytopenia; Picornaviridae Infections; Plasma Exchange; Pneumonia, Viral; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rhinovirus; Sepsis; Survivors | 2017 |
Hepatotoxicity During Maintenance Therapy and Prognosis in Children With Acute Lymphoblastic Leukemia.
Topics: Adolescent; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Infant; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 2017 |
Long-term brain structural magnetic resonance imaging and cognitive functioning in children treated for acute lymphoblastic leukemia with high-dose methotrexate chemotherapy alone or combined with CNS radiotherapy at reduced total dose to 12 Gy.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Treatment Outcome; Young Adult | 2017 |
Survival Outcome of Filipino Children With Acute Lymphoblastic Leukemia Treated With Modified Berlin-Frankfurt-Muenster/Hong Kong Acute Lymphoblastic Leukemia (BFM95/HKALL97) Protocol in a Tertiary General Hospital From January 2005 to December 2009: A Re
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cohort Studies; Consolidation Chemotherapy; Daunorubicin; Disease-Free Survival; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Philippines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Tertiary Care Centers; Treatment Outcome; Vincristine | 2017 |
Sinusoidal Obstruction Syndrome During Maintenance Therapy for Acute Lymphoblastic Leukemia With 6-Mercaptopurine and Methotrexate: A Pediatric Case Report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Biopsy; Child; Drug Interactions; Hepatic Veno-Occlusive Disease; Humans; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Multimodal Imaging; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2017 |
A Stroke Mimic: Methotrexate-induced Neurotoxicity in the Emergency Department.
Topics: Adolescent; Antimetabolites, Antineoplastic; Combined Modality Therapy; Dextromethorphan; Emergency Service, Hospital; Excitatory Amino Acid Antagonists; Facial Paralysis; Female; Humans; Lower Extremity; Methotrexate; Muscle Hypotonia; Muscle Weakness; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; Upper Extremity | 2017 |
Repeated Episodes of Leukoencephalopathy after High-dose Methotrexate in a Child with Acute Lymphoblastic Leukemia.
Topics: Adolescent; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Female; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2017 |
mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cyclin D; Cyclins; Drug Resistance, Neoplasm; Drug Synergism; Humans; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein Kinases; Tetrahydrofolate Dehydrogenase; TOR Serine-Threonine Kinases; Transplantation, Heterologous | 2008 |
Pure motor lumbosacral radiculopathy after intrathecal chemotherapy.
Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Dexamethasone; Humans; Hydrocortisone; Injections, Spinal; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Middle Aged; Paraparesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiculopathy; Sacrum; Spinal Nerve Roots; Vincristine | 2008 |
[Association between mthfr gene polymorphisms and toxicity of HDMTX chemotherapy in acute lymphocytic leukemia].
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2008 |
Prophylaxis of central nervous system leukemia: a case of chronic myeloid leukemia with lymphoid blast crisis treated with imatinib mesylate.
Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blast Crisis; Blood Cell Count; Central Nervous System Neoplasms; Chemoprevention; Child; Clinical Protocols; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Imatinib Mesylate; Injections, Spinal; Methotrexate; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction | 2008 |
Treatment of pediatric acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Blast Crisis; Child; Child, Preschool; Humans; Injections, Spinal; Meningeal Neoplasms; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Risk Factors | 2008 |
Influence of methylene tetrahydrofolate reductase polymorphisms and coadministration of antimetabolites on toxicity after high dose methotrexate.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Cytarabine; Female; Humans; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neutropenia; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Thrombocytopenia | 2008 |
Immune reconstitution during maintenance therapy in children with acute lymphoblastic leukemia, relation to co-existing infection.
Topics: Adolescent; Adrenal Cortex Hormones; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Case-Control Studies; CD4-CD8 Ratio; Child; Child, Preschool; Female; Humans; Immunoglobulins; Infections; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2008 |
Severe neurotoxicities in a case of Charcot-Marie-Tooth disease type 2 caused by vincristine for acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Charcot-Marie-Tooth Disease; Contraindications; Cytarabine; Daunorubicin; Etoposide; Gait Disorders, Neurologic; Humans; Male; Mercaptopurine; Methotrexate; Muscle Weakness; Neural Conduction; Peripheral Nervous System Diseases; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine | 2008 |
Outcome and toxicity of chemotherapy for acute lymphoblastic leukemia in children with Down syndrome.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Dose-Response Relationship, Drug; Down Syndrome; Humans; Matched-Pair Analysis; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Survival Analysis; Treatment Outcome | 2009 |
Recurrent intrathecal methotrexate induced neurotoxicity in an adolescent with acute lymphoblastic leukemia: Serial clinical and radiologic findings.
Topics: Adolescent; Diffusion; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Speech Disorders | 2009 |
Marked increase of normal blast morphologically mimicking leukemic clone in acute lymphoblastic leukemia patient following G-CSF therapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Granulocyte Colony-Stimulating Factor; Humans; Lymphocyte Activation; Lymphocytes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recovery of Function; Remission Induction; Time Factors | 2008 |
Veno-occlusive disease of the liver during induction therapy for acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Daunorubicin; Female; Fibrinolytic Agents; Hepatic Veno-Occlusive Disease; Humans; Liver; Marfan Syndrome; Methotrexate; Middle Aged; Polydeoxyribonucleotides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine | 2008 |
Practice of central nervous system prophylaxis and treatment in acute leukemias in Spain. Prospective registry study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Injections, Spinal; Leukemia, Myeloid, Acute; Liposomes; Longitudinal Studies; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Registries; Spain | 2008 |
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity.
Topics: Adolescent; Cerebrospinal Fluid; Child; Child, Preschool; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Intractable epilepsy in patients treated for childhood acute lymphocytic leukemia.
Topics: Adult; Antirheumatic Agents; Brain; Cranial Irradiation; Epilepsy; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
MTHFR 677 C>T genotype and adverse outcomes in treatment of childhood ALL: is the jury in?
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Antineoplastic Agents; Child; Cytosine; Genotype; Humans; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2009 |
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia.
Topics: Biomarkers, Tumor; Cation Transport Proteins; Cell Line, Transformed; Cells, Cultured; Child; Child, Preschool; Female; Formins; Gene Dosage; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Genetic Predisposition to Disease; Genetic Variation; Genome, Human; Humans; Infant; Malate Dehydrogenase; Male; Methotrexate; Microfilament Proteins; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Phenotype; Phosphoric Monoester Hydrolases; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Smad2 Protein; Smad4 Protein; Tumor Suppressor Proteins | 2009 |
Folate homeostasis in cerebrospinal fluid during therapy for acute lymphoblastic leukemia.
Topics: Administration, Oral; Adolescent; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Dementia, Vascular; Folic Acid; Folic Acid Antagonists; Homeostasis; Homocysteine; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; tau Proteins; Young Adult | 2009 |
[Effects of high-dose methotrexate therapy on intestinal bacterial flora in children with acute lymphoblastic leukemia].
Topics: Antimetabolites, Antineoplastic; Bacillus; Case-Control Studies; Child; Child, Preschool; DNA, Bacterial; Escherichia coli; Feces; Female; Humans; Intestines; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors.
Topics: Adolescent; Analysis of Variance; Anisotropy; Antimetabolites, Antineoplastic; Brain Neoplasms; Case-Control Studies; Child; Corpus Callosum; Diffusion Magnetic Resonance Imaging; Humans; Intelligence; Internal Capsule; Medulloblastoma; Mental Processes; Methotrexate; Motor Activity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Statistics, Nonparametric; Survivors | 2009 |
Intrathecal methotrexate-induced acute chorea.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Child; Chorea; Female; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2009 |
Poor treatment compliance in children with down syndrome and acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Down Syndrome; Female; Guideline Adherence; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Patient Compliance; Physician's Role; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Survival Rate; Treatment Outcome | 2009 |
Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
Topics: Adult; Alternative Splicing; Blotting, Northern; Cell Proliferation; Drug Resistance, Neoplasm; Exons; Folic Acid; Folic Acid Antagonists; Humans; Immunoenzyme Techniques; Introns; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Distribution | 2009 |
[A retrospective analysis of clinical outcomes in 225 childhood with acute lymphoblastic leukemia].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome | 2008 |
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Etoposide; Female; Flow Cytometry; Follow-Up Studies; Genotype; Germ-Line Mutation; Humans; Infant; Linear Models; Linkage Disequilibrium; Male; Methotrexate; Neoplasm, Residual; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Retrospective Studies; Risk Assessment; Risk Factors | 2009 |
Relationship between HLA-DP supertype and survival in childhood acute lymphoblastic leukaemia: evidence for selective loss of immunological control of residual disease?
Topics: Adolescent; Biomarkers, Tumor; Chi-Square Distribution; Child; Child, Preschool; Disease-Free Survival; Female; Genetic Predisposition to Disease; Genotype; HLA-DP Antigens; HLA-DP beta-Chains; Humans; Immunosuppressive Agents; Infant; Kaplan-Meier Estimate; Male; Methotrexate; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Randomized Controlled Trials as Topic; Statistics, Nonparametric; Treatment Outcome | 2009 |
Changes in acetylcholinesterase (AchE) activity in lymphocytes and whole blood in acute lymphoblastic leukemia patients.
Topics: Acetylcholinesterase; Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cytarabine; Female; Humans; Lymphocytes; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2009 |
Effective treatment of advanced-stage childhood lymphoblastic lymphoma without prophylactic cranial irradiation: results of St Jude NHL13 study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Etoposide; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; T-Lymphocytes; Treatment Outcome; Vincristine | 2009 |
Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Humans; Immunoenzyme Techniques; Infant; Karyotyping; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Factors; Stem Cell Transplantation; Survival Rate; Treatment Outcome | 2009 |
High-dose methotrexate: the rationale...
Topics: Antimetabolites, Antineoplastic; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Additional chromosomal abnormalities and their prognostic significance in adult Philadelphia-positive acute lymphoblastic leukemia: with or without imatinib in chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamides; Chromosome Aberrations; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Etoposide; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Pyrimidines; Salvage Therapy; Vincristine; Vindesine; Young Adult | 2009 |
Adults with acute lymphoblastic leukemia and translocation (1;19) abnormality have a favorable outcome with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and high-dose cytarabine chemotherapy
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Humans; Methotrexate; Middle Aged; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Translocation, Genetic; Treatment Outcome; Vincristine | 2009 |
Methotrexate and aminopterin exhibit similar in vitro and in vivo preclinical activity against acute lymphoblastic leukaemia and lymphoma.
Topics: Aminopterin; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Humans; Inhibitory Concentration 50; Lymphoma; Methotrexate; Mice; Mice, SCID; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Regression Analysis; Xenograft Model Antitumor Assays | 2009 |
Mesial temporal sclerosis associated with methotrexate-induced leukoencephalopathy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child, Preschool; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Methotrexate; Positron-Emission Tomography; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sclerosis; Temporal Lobe | 2009 |
Posterior reversible encephalopathy syndrome associated with methotrexate neurotoxicity: conventional magnetic resonance and diffusion-weighted imaging findings.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Diseases; Diffusion Magnetic Resonance Imaging; Female; Follow-Up Studies; Humans; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Phlebography; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Status Epilepticus; Syndrome | 2009 |
False-photosensitivity and transient hemiparesis following high-dose intravenous and intrathecal methotrexate for treatment of acute lymphoblastic leukemia.
Topics: Adolescent; Dysarthria; False Positive Reactions; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Nucleic Acid Synthesis Inhibitors; Paresis; Photosensitivity Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 2009 |
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity.
Topics: Adolescent; Brain Infarction; Child; Child, Preschool; Demyelinating Diseases; Facial Paralysis; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Successful treatment of human metapneumovirus pneumonia using combination therapy with intravenous ribavirin and immune globulin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Asparaginase; Child, Preschool; Combined Modality Therapy; Daunorubicin; Female; Humans; Immunocompromised Host; Immunoglobulins, Intravenous; Metapneumovirus; Methotrexate; Paramyxoviridae Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Ribavirin; Vincristine | 2009 |
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Topics: Adolescent; Alleles; Anemia; Antimetabolites, Antineoplastic; Bone Marrow; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Gene Frequency; Genotype; Humans; Kidney; Liver; Lymphoma, Non-Hodgkin; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytopenia; Time Factors | 2009 |
Intracranial pressure in pediatric patients with acute lymphoblastic leukemia.
Topics: Child; Humans; Intracranial Pressure; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Child; Drug Resistance, Neoplasm; Folic Acid; Gene Expression Profiling; Humans; Methotrexate; Nucleotides; Oligonucleotide Array Sequence Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes | 2009 |
Oxidative stress and executive function in children receiving chemotherapy for acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Emotions; Female; Humans; Male; Memory; Methotrexate; Oxidative Stress; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Verbal Behavior | 2009 |
Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Alleles; Amino Acid Substitution; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Gene Frequency; Genotype; Humans; Male; Mercaptopurine; Methotrexate; Multidrug Resistance-Associated Proteins; Mutation, Missense; Pilot Projects; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Retrospective Studies; Survival Rate | 2009 |
On the malignant potential of thiopurine therapy.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cranial Irradiation; Humans; Hypoxanthine Phosphoribosyltransferase; Immunoenzyme Techniques; Karyotyping; Mercaptopurine; Methotrexate; Methyltransferases; Mutation; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Risk Factors; Stem Cell Transplantation; Survival Rate; Treatment Outcome | 2009 |
Toxic non-resorptive internal hydrocephalus as a result of haemorrhagic ventriculitis during induction chemotherapy of Bcr-Abl positive acute lymphoblastic leukaemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain; Cerebral Ventricles; Cyclophosphamide; Female; Fusion Proteins, bcr-abl; Humans; Hydrocephalus; Magnetic Resonance Imaging; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2010 |
[Prophylaxis and treatment of modified BFM-90 regimen for lymphoblastic lymphoma in children and adolescents accompanied with infection].
Topics: Adolescent; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Cephalosporins; Child; Child, Preschool; Cross Infection; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Progression; Female; Humans; Itraconazole; Male; Mercaptopurine; Methotrexate; Mouth Diseases; Mycoses; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Respiratory Tract Infections; Vincristine | 2009 |
Voxel-based analysis of T2 hyperintensities in white matter during treatment of childhood leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Cerebral Ventricles; Child; Child, Preschool; Female; Frontal Lobe; Humans; Infant; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Nerve Fibers, Myelinated; Parietal Lobe; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Factors | 2009 |
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Female; Folic Acid; Follow-Up Studies; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Tetrahydrofolate Dehydrogenase; Young Adult | 2009 |
Serendipity-methotrexate and 6-mercaptopurine for continuation therapy for patients with acute lymphoblastic leukemia: the leukemic stem cell and beyond?
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Molecular genetic analysis of a primitive neuroectodermal tumor arising after intracranial radiation and chemotherapy for leukemia.
Topics: Adult; Bone Marrow Transplantation; Brain; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 17; Cranial Irradiation; Humans; Loss of Heterozygosity; Magnetic Resonance Imaging; Male; Methotrexate; Neuroectodermal Tumors, Primitive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-ret; PTEN Phosphohydrolase; Tumor Suppressor Protein p53; Whole-Body Irradiation | 2009 |
Germline genomic variants associated with childhood acute lymphoblastic leukemia.
Topics: Alleles; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 7; Cohort Studies; DNA-Binding Proteins; Dopa Decarboxylase; Gene Dosage; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Germ Cells; Germ-Line Mutation; Haplotypes; Humans; Ikaros Transcription Factor; Linkage Disequilibrium; Methotrexate; Odds Ratio; Oncogene Proteins, Fusion; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Probability; Reproducibility of Results; Risk Factors; Trans-Activators; Transcription Factors; White People | 2009 |
Weight patterns in children with higher risk ALL: A report from the Children's Oncology Group (COG) for CCG 1961.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Mass Index; Child; Child, Preschool; Cranial Irradiation; Cytarabine; Daunorubicin; Ethnicity; Female; Gastrointestinal Diseases; Glucose Intolerance; Humans; Incidence; Male; Methotrexate; Obesity; Pancreatitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Randomized Controlled Trials as Topic; Retrospective Studies; Risk; Vincristine; Weight Gain; Weight Loss; Young Adult | 2009 |
Acute methotrexate neurotoxicity with choreiform movements and focal neurological deficits: a case report.
Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Ataxia; Brain; Chorea; Confusion; Headache; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Nausea; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reflex, Abnormal | 2009 |
Evaluation of the late effects of CNS prophylactic treatment in childhood acute lymphoblastic leukemia (ALL) using magnetic resonance spectroscopy.
Topics: Adolescent; Aspartic Acid; Brain Injuries; Case-Control Studies; Child; Child, Preschool; Choline; Cranial Irradiation; Creatine; Drug Administration Routes; Drug Therapy; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tissue Distribution | 2010 |
Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia.
Topics: Allopurinol; Child; Child, Preschool; Female; Humans; Hyperuricemia; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Urate Oxidase; Uric Acid | 2010 |
Random serum methotrexate determinations for assessing compliance with maintenance therapy for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Immunoassay; Interviews as Topic; Male; Methotrexate; Monitoring, Physiologic; Outcome Assessment, Health Care; Patient Compliance; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
DNA variants in region for noncoding interfering transcript of dihydrofolate reductase gene and outcome in childhood acute lymphoblastic leukemia.
Topics: Adult; Case-Control Studies; Child; Cohort Studies; DNA; Female; Genetic Variation; Haplotypes; Humans; Male; Methotrexate; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Tetrahydrofolate Dehydrogenase | 2009 |
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Gastrointestinal Diseases; Genetic Predisposition to Disease; Genome-Wide Association Study; Germ-Line Mutation; Humans; Infant; Linear Models; Linkage Disequilibrium; Liver-Specific Organic Anion Transporter 1; Logistic Models; Male; Methotrexate; Organic Anion Transporters; Phenotype; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Risk Assessment; Risk Factors; Treatment Outcome | 2009 |
Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia.
Topics: Alleles; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Egypt; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasm Proteins; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Stomatitis; Vincristine | 2010 |
Working memory in survivors of childhood acute lymphocytic leukemia: functional neuroimaging analyses.
Topics: Adolescent; Age of Onset; Antineoplastic Agents; Brain; Brain Mapping; Child; Child, Preschool; Cytarabine; Female; Humans; Intelligence Tests; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Short-Term; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors | 2010 |
DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytosol; DNA; Drug Monitoring; Erythrocytes; Female; Guanine Nucleotides; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thionucleotides | 2010 |
[Blood concentration monitoring during high-dose methotrexate treatment].
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Drug Monitoring; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2009 |
The impact of high-dose methotrexate on intracellular 6-mercaptopurine disposition during interval therapy of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biotransformation; Child; Child, Preschool; Drug Interactions; Erythrocytes; Female; Humans; Inactivation, Metabolic; Injections, Intravenous; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thioguanine | 2010 |
Prospective bone ultrasound patterns during childhood acute lymphoblastic leukemia treatment.
Topics: Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Bone Density; Chi-Square Distribution; Child; Child, Preschool; Cyclophosphamide; Cytosine; Female; Fractures, Bone; Humans; Male; Mercaptopurine; Methotrexate; Osteonecrosis; Osteoporosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Time Factors; Ultrasonography; Vincristine | 2010 |
Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; CCAAT-Binding Factor; Cell Line, Tumor; Exons; Gene Expression Regulation, Enzymologic; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Methotrexate; Peptide Synthases; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sp1 Transcription Factor; Vorinostat | 2010 |
Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy.
Topics: Adaptation, Psychological; Adolescent; Antineoplastic Agents; Brain; Child; Child Behavior; Child, Preschool; Female; Humans; Male; Methotrexate; Oxidation-Reduction; Oxidative Stress; Phosphatidylcholines; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
Relationship of the reduced folate carrier gene polymorphism G80A to methotrexate plasma concentration, toxicity, and disease outcome in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genetic Predisposition to Disease; Humans; Male; Membrane Transport Proteins; Methotrexate; Osmolar Concentration; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Reduced Folate Carrier Protein; Treatment Outcome; Young Adult | 2010 |
Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico.
Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Female; gamma-Glutamyl Hydrolase; Gene Frequency; Genotype; Humans; Infant; Male; Methotrexate; Mexico; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk; Treatment Outcome | 2010 |
Solar burn reactivation induced by methotrexate.
Topics: Acute Disease; Acute Kidney Injury; Adolescent; Antineoplastic Agents, Phytogenic; Blood Urea Nitrogen; Creatinine; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sunburn; Treatment Outcome; Ultraviolet Rays; Vincristine | 2010 |
Hyperperfusion on magnetic resonance imaging in acute chemotherapy-related leukoencephalopathy.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Diagnosis, Differential; Humans; Leukoencephalopathies; Magnetic Resonance Imaging; Male; Methotrexate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; Vincristine | 2010 |
Methotrexate-induced side effects are not due to differences in pharmacokinetics in children with Down syndrome and acute lymphoblastic leukemia.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Dose-Response Relationship, Drug; Down Syndrome; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2010 |
New agents for the treatment of patients with acute lymphoblastic leukemia.
Topics: Age Factors; Antibodies, Monoclonal; Asparaginase; Disease-Free Survival; Enzyme Inhibitors; HSP90 Heat-Shock Proteins; Humans; Liposomes; Methotrexate; Nucleosides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Notch; Recurrence | 2008 |
Prospective study of hemostatic alterations in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Antithrombins; Asparaginase; Case-Control Studies; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Fibrin Fibrinogen Degradation Products; Humans; Infant; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; P-Selectin; Plasminogen Activator Inhibitor 1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Risk Factors; Thrombin; Thrombophilia; Venous Thromboembolism; Vincristine; von Willebrand Factor | 2010 |
Pontomedullary hemorrhage due to vascular malformation of basilar artery after treatment for acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Arteries; Child, Preschool; Combined Modality Therapy; Humans; Injections, Spinal; Intracranial Arterial Diseases; Intracranial Hemorrhages; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography; Radiotherapy Dosage | 2010 |
Guillain-Barré syndrome mimicking acute methotrexate-associated encephalopathy in an adolescent patient with lymphoblastic lymphoma.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Diseases; Diagnosis, Differential; Female; Guillain-Barre Syndrome; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2010 |
Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Electroencephalography; Female; Humans; Infant; Leukemic Infiltration; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Tomography, X-Ray Computed; Vincristine | 2010 |
Folylpolyglutamate synthetase gene transcription is regulated by a multiprotein complex that binds the TEL-AML1 fusion in acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Leukemic; Histone Deacetylase 1; Methotrexate; Multiprotein Complexes; Oncogene Proteins, Fusion; Peptide Synthases; Pre-B-Cell Leukemia Transcription Factor 1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Proto-Oncogene Proteins; Retinoblastoma Protein; Transcription, Genetic | 2010 |
Spinal cord compression by epidural involvement over 21 vertebral levels in acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Epidural Neoplasms; Humans; Lumbar Vertebrae; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Sacrococcygeal Region; Spinal Cord Compression; Thoracic Vertebrae; Vincristine | 2011 |
Anthracycline dose intensification in adult acute lymphoblastic leukemia: lack of benefit in the context of the fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone regimen.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Doxorubicin; Drug Administration Schedule; Humans; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Salvage Therapy; Treatment Outcome; Vincristine | 2010 |
Overt testicular disease at diagnosis in childhood acute lymphoblastic leukemia: prognostic significance and role of testicular irradiation.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Male; Methotrexate; Multivariate Analysis; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Analysis; Testicular Neoplasms | 2010 |
Old drug--new insights--better treatment?
Topics: Antimetabolites, Antineoplastic; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Leukemic; Histone Deacetylase 1; Methotrexate; Multiprotein Complexes; Oncogene Proteins, Fusion; Peptide Synthases; Pre-B-Cell Leukemia Transcription Factor 1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Proto-Oncogene Proteins; Retinoblastoma Protein; Transcription, Genetic | 2010 |
Cognitive reserve and brain volumes in pediatric acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Child; Child, Preschool; Cognition; Cognitive Reserve; Female; Humans; Image Processing, Computer-Assisted; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survivors; Treatment Outcome; Young Adult | 2010 |
Chemotherapy-related delayed bilateral spontaneous pneumothorax and lung fibrosis: methotrexate or cyclophosphamide, or both?
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Humans; Male; Methotrexate; Pneumothorax; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Fibrosis; Radiography | 2010 |
Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis.
Topics: Antimetabolites, Antineoplastic; Child, Preschool; Female; Folic Acid; Humans; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
The sequence of application of methotrexate and histone deacetylase inhibitors determines either a synergistic or an antagonistic response in childhood acute lymphoblastic leukemia cells.
Topics: Cell Line, Tumor; Child; Drug Antagonism; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
Outcome of treatment of adult acute lymphoblastic leukemia with hyperfractionated cyclophosphamide, doxorubicin, vincristine, dexamethasone/methotrexate, cytarabine: results from an Australian population.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Australia; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Treatment Outcome; Vincristine; Young Adult | 2011 |
Transient leukoencephalopathy after intrathecal methotrexate mimicking stroke.
Topics: Adolescent; Antimetabolites, Antineoplastic; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging; Female; Humans; Injections, Spinal; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke | 2011 |
The effect of cerebral spinal fluid replacement on acute myelopathy induced by intrathecal therapy of leukemia.
Topics: Acute Disease; Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cerebrospinal Fluid; Cytarabine; Dexamethasone; Female; Fluid Therapy; Humans; Injections, Spinal; Methotrexate; Paraplegia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases; Treatment Outcome | 2011 |
AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Apoptosis; Carbon; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Endoplasmic Reticulum; Humans; Methotrexate; Molecular Targeted Therapy; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Ribonucleotides; Signal Transduction | 2011 |
Erythroblastic islands.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Combined Modality Therapy; Dexamethasone; Erythroblasts; Erythropoiesis; Female; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2011 |
Cellular elements of the subarachnoid space promote ALL survival during chemotherapy.
Topics: Antineoplastic Agents; Astrocytes; Cell Communication; Cell Line, Tumor; Cell Survival; Cells, Cultured; Choroid Plexus; Coculture Techniques; Cytarabine; Dexamethasone; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Meninges; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Subarachnoid Space; Time Factors | 2011 |
Severe hypoglycemic seizures in a child receiving 6-mercaptopurine.
Topics: Anti-Infective Agents; Antimetabolites, Antineoplastic; Child, Preschool; Humans; Hypoglycemia; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Trimethoprim, Sulfamethoxazole Drug Combination | 2011 |
Folate fortification and survival of children with acute lymphoblastic leukemia.
Topics: Child; Child, Preschool; Databases, Factual; Folic Acid; Folic Acid Antagonists; Food, Fortified; Humans; Infant; Infant, Newborn; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Analysis; Treatment Failure; World Health Organization | 2011 |
Methotrexate pharmacokinetics in childhood acute lymphoblastic leukaemia: a prognostic value?
Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Area Under Curve; Bayes Theorem; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Models, Biological; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Time Factors | 2011 |
Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Infant; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Organic Anion Transporters; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2011 |
Autism Speaks: meeting on folate metabolism and Autism spectrum disorders, March 19-20, 2009, Washington, DC.
Topics: Autistic Disorder; Biological Transport; Brain; Cognition Disorders; District of Columbia; Folic Acid; Genomic Instability; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, N-Methyl-D-Aspartate; Vitamin B 12 | 2011 |
[A case of the association of acute lymphoblastic lymphoma with active tuberculosis in the child: a Malian case].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Child, Preschool; Cytarabine; Humans; Injections, Intramuscular; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Tuberculosis, Pulmonary; Vincristine | 2010 |
Towards personalized medicine - the role of methotrexate.
Topics: Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Precision Medicine; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child, Preschool; Female; Folic Acid; Genotype; Humans; Lymphoma; Male; Metabolic Networks and Pathways; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mucositis; Nonlinear Dynamics; Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Retrospective Studies; Thrombocytopenia | 2011 |
Methotrexate leukoencephalopathy mimics acute progressive stroke.
Topics: Adolescent; Antimetabolites, Antineoplastic; Diagnosis, Differential; Humans; Leukoencephalopathies; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke | 2011 |
Effects of methylenetetrahydrofolate reductase gene polymorphisms on toxicities during consolidation therapy in pediatric acute lymphoblastic leukemia in a Chinese population.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asian People; Child; Child, Preschool; China; Drug-Related Side Effects and Adverse Reactions; Female; Gene Frequency; Genotype; Haplotypes; Humans; Infant; Linkage Disequilibrium; Logistic Models; Male; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neutropenia; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Skin Diseases; Thrombocytopenia | 2011 |
Genotyping of single nucleotide polymorphism in γ-glutamyl hydrolase gene by capillary electrophoresis.
Topics: Antimetabolites, Antineoplastic; Electrophoresis, Capillary; gamma-Glutamyl Hydrolase; Genotype; Humans; Hypromellose Derivatives; Methotrexate; Methylcellulose; Polymorphism, Single Nucleotide; Polymorphism, Single-Stranded Conformational; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Temperature | 2011 |
Methotrexate toxicity and efficacy during the consolidation phase in paediatric acute lymphoblastic leukaemia and MTHFR polymorphisms as pharmacogenetic determinants.
Topics: Child; Child, Preschool; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymerase Chain Reaction; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
Suspicion of drug-drug interaction between high-dose methotrexate and proton pump inhibitors: a case report - should the practice be changed?
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acyclovir; Antimetabolites, Antineoplastic; Antiviral Agents; Drug Interactions; Female; Fluoxetine; Humans; Methotrexate; Middle Aged; Pantoprazole; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proton Pump Inhibitors; Renal Insufficiency; Valacyclovir; Valine | 2011 |
Polymorphism in multidrug resistance-associated protein gene 3 is associated with outcomes in childhood acute lymphoblastic leukemia.
Topics: Alleles; Biomarkers, Pharmacological; Disease-Free Survival; Genetic Association Studies; Genotype; Haplotypes; Humans; Methotrexate; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2012 |
Cord blood transplantation from unrelated donors for children with acute lymphoblastic leukemia in Japan: the impact of methotrexate on clinical outcomes.
Topics: Blood Platelets; Child; Child, Preschool; Cord Blood Stem Cell Transplantation; Female; Graft vs Host Disease; Humans; Infant, Newborn; Japan; Male; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk Factors; Survival Rate; Transplantation Conditioning; Treatment Outcome; Unrelated Donors; Whole-Body Irradiation | 2011 |
Ultrafast selective quantification of methotrexate in human plasma by high-throughput MALDI-isotope dilution mass spectrometry.
Topics: Deuterium; Drug Stability; Fluorescence Polarization Immunoassay; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry | 2011 |
A rare complication of intrathecal methotrexate in a child with acute lymphoblastic leukemia.
Topics: Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Child; Dexamethasone; Female; Humans; Injections, Spinal; Leucovorin; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography; Time Factors; Vitamin B Complex | 2011 |
Numb chin syndrome in acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Child; Chin; Cytarabine; Female; Humans; Hypesthesia; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Skull | 2011 |
Methotrexate consolidation treatment according to pharmacogenetics of MTHFR ameliorates event-free survival in childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Genotype; Humans; Infant, Newborn; Kaplan-Meier Estimate; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Neoplasm Staging; Neuromuscular Junction Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Rate; Survivors; Vincristine; Young Adult | 2012 |
Are we getting closer to using methotrexate in an optimal manner?
Topics: Antimetabolites, Antineoplastic; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
MTHFR 677TT genotype and toxicity of methotrexate: controversial results.
Topics: Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2011 |
Expression of liquoral neuroprotection markers in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Blotting, Western; Brain Injuries; Child; Child, Preschool; Doublecortin Domain Proteins; Doublecortin Protein; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Methotrexate; Microtubule-Associated Proteins; Nerve Growth Factors; Neuropeptides; Neuroprotective Agents; Phosphopyruvate Hydratase; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Up-Regulation | 2011 |
Somatosensory evoked potential for detection of subclinical neuropathy in Egyptian children with acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Computer Simulation; Egypt; Electrodes; Electrophysiology; Evoked Potentials, Somatosensory; Female; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk | 2010 |
Homozygosity for the rs9939609T allele of the FTO gene may have protective effect on becoming overweight in survivors of childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Genetic Association Studies; Homozygote; Humans; Male; Methotrexate; Obesity; Odds Ratio; Overweight; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proteins; Radiotherapy; Risk Factors; Survivors; Thioguanine; Vincristine; Young Adult | 2011 |
Strength capacity in young patients who are receiving maintenance therapy for acute lymphoblastic leukemia: a case-control study.
Topics: Adolescent; Age Factors; Antineoplastic Agents; Case-Control Studies; Child; Dexamethasone; Female; Humans; Male; Mercaptopurine; Methotrexate; Muscle Strength; Muscle Stretching Exercises; Muscle Weakness; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Sex Factors; Time Factors; Vincristine | 2011 |
The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biotransformation; Bone Neoplasms; Child; Chromatography, High Pressure Liquid; Drug Monitoring; Fluorescence Polarization Immunoassay; Humans; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Young Adult | 2011 |
[An extremely high serum methotrexate concentration associated with acute renal failure in a patient with acute lymphoblastic leukemia after conduction of high dose consolidation].
Topics: Acute Kidney Injury; Adult; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Humans; Kidney Function Tests; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 2011 |
[Pharmacokinetic analysis of high-dose methotrexate treatments in children with hematologic malignancies].
Topics: Adolescent; Antimetabolites, Antineoplastic; Blood Proteins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Creatinine; Drug Administration Schedule; Female; Humans; Kidney; Liver; Liver Failure; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency; Stomatitis; Time Factors; Treatment Outcome | 2011 |
Important role of caspase-8 for chemosensitivity of ALL cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 8; Cell Line, Tumor; Cell Survival; Child; Cytarabine; Dexamethasone; Doxorubicin; Enzyme Activation; Humans; Jurkat Cells; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA Interference; Thioguanine; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2011 |
Role of base-excision repair in the treatment of childhood acute lymphoblastic leukaemia with 6-mercaptopurine and high doses of methotrexate.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Child; Child, Preschool; Comet Assay; DNA Damage; DNA Repair; Humans; Hydrogen Peroxide; Lymphocytes; Male; Mercaptopurine; Methotrexate; Oxidation-Reduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Uracil; Young Adult | 2012 |
Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Female; Folic Acid; Genotype; Humans; Infant; Infant, Newborn; Male; Metabolic Networks and Pathways; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis; Thymidylate Synthase | 2012 |
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Clinical Trials as Topic; Cohort Studies; Exons; Female; Haplotypes; Humans; Infant; Liver-Specific Organic Anion Transporter 1; Male; Methotrexate; Neoplasm Proteins; Organic Anion Transporters; Pharmacogenetics; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Liquid chromatography-tandem mass spectrometry quantification of 6-thioguanine in DNA using endogenous guanine as internal standard.
Topics: Calibration; Child; Chromatography, Liquid; DNA; DNA, Neoplasm; Guanine; Humans; Jurkat Cells; Leukocytes; Limit of Detection; Linear Models; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Thioguanine | 2012 |
Cryptosporidium gastroenteritis in Egyptian children with acute lymphoblastic leukemia: magnitude of the problem.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Cryptosporidiosis; Cryptosporidium parvum; Diarrhea; Egypt; Entamoeba histolytica; Feces; Female; Gastroenteritis; Giardia lamblia; Gram-Negative Bacteria; Humans; Immunocompromised Host; Immunosuppressive Agents; Infant; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 2012 |
Experience with high dose methotrexate therapy in childhood acute lymphoblastic leukemia in a tertiary care cancer centre of a developing country.
Topics: Antimetabolites, Antineoplastic; Cancer Care Facilities; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Leucovorin; Male; Methotrexate; Mucositis; Neutropenia; Patient Readmission; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2012 |
Effect of high-dose methotrexate chemotherapy on intestinal Bifidobacteria, Lactobacillus and Escherichia coli in children with acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Bifidobacterium; Child; DNA, Bacterial; Escherichia coli; Female; Humans; Intestinal Mucosa; Lactobacillus; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction | 2012 |
Population analysis of pharmacogenetic polymorphisms related to acute lymphoblastic leukemia drug treatment.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biotransformation; Brazil; Gene Frequency; Genetic Loci; Genetic Markers; Genotype; Glucocorticoids; HapMap Project; Humans; Mercaptopurine; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Racial Groups; Regression Analysis | 2012 |
High dose methotrexate treatment in childhood ALL: pilot study on the impact of the MTHFR 677C>T and 1298A>C polymorphisms on MTX-related toxicity.
Topics: Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genetic Carrier Screening; Genotype; Homozygote; Humans; Leukopenia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Pilot Projects; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Treatment Outcome | 2012 |
DNA synthesis as a therapeutic target: the first 65 years.
Topics: Aminopterin; Antimetabolites, Antineoplastic; DNA Replication; Fluorouracil; Folic Acid; Folic Acid Antagonists; History, 20th Century; Humans; Hydroxyurea; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase | 2012 |
Longitudinal language outcomes following intrathecal chemotherapy for acute lymphoblastic leukaemia.
Topics: Antineoplastic Agents; Case-Control Studies; Child; Child, Preschool; Cognition; Drug Therapy; Female; Follow-Up Studies; Humans; Injections, Spinal; Language; Language Tests; Longitudinal Studies; Male; Methotrexate; Outcome Assessment, Health Care; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 2013 |
High incidence of vertebral fractures in children with acute lymphoblastic leukemia 12 months after the initiation of therapy.
Topics: Adolescent; Bone Density; Child; Child, Preschool; Female; Glucocorticoids; Humans; Incidence; Infant; Logistic Models; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Spinal Fractures; Time Factors | 2012 |
Methotrexate sodium-associated UV reactivation in a patient with acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Humans; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sunscreening Agents; Ultraviolet Rays | 2012 |
Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL.
Topics: Adolescent; Biomarkers, Pharmacological; Child; Child, Preschool; Female; Folic Acid; Genetic Association Studies; Glutamate Carboxypeptidase II; Haplotypes; Humans; Male; Mercaptopurine; Metabolic Networks and Pathways; Methotrexate; Methyltransferases; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrophosphatases | 2012 |
Chemotherapy-related changes in central nervous system phospholipids and neurocognitive function in childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Central Nervous System; Child; Child, Preschool; Chromatography, High Pressure Liquid; Cognition; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Multivariate Analysis; Neuropsychological Tests; Outcome Assessment, Health Care; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sphingomyelins; Time Factors | 2013 |
A second target of benzamide riboside: dihydrofolate reductase.
Topics: Adenine Nucleotides; Benzamides; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Humans; IMP Dehydrogenase; Methotrexate; Molecular Targeted Therapy; NADP; Nucleosides; Phosphotransferases (Alcohol Group Acceptor); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase | 2012 |
[Association between the methylenetetrahydrofolate reductase gene polymorphisms and haplotype with toxicity response of high dose methotrexate chemotherapy].
Topics: Adolescent; Alleles; Child; Child, Preschool; Dose-Response Relationship, Drug; Genotype; Haplotypes; Humans; Infant; Linkage Disequilibrium; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2012 |
Cytomegalovirus retinitis as an adverse immunological effect of pulses of vincristine and dexamethasone in maintenance therapy for childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cytomegalovirus Retinitis; Dexamethasone; Female; Humans; Maintenance Chemotherapy; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2013 |
Association between polymorphisms of dihydrofolate reductase and gamma glutamyl hydrolase genes and toxicity of high dose methotrexate in children with acute lymphoblastic leukemia.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Female; gamma-Glutamyl Hydrolase; Gene Frequency; Genotype; Humans; Infant; Leukopenia; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Thrombocytopenia | 2012 |
Delayed elimination of methotrexate by cola beverages in a pediatric acute lymphoblastic leukemia population.
Topics: Age Factors; Beverages; Child; Cola; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 2013 |
Prevention of bone growth defects, increased bone resorption and marrow adiposity with folinic acid in rats receiving long-term methotrexate.
Topics: Adiposity; Animals; Antimetabolites, Antineoplastic; Apoptosis; Bone Marrow; Bone Resorption; Child; Chondrocytes; Cytokines; Femur; Gene Expression; Humans; Leucovorin; Male; Methotrexate; Osteoblasts; Osteoclasts; Osteogenesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RANK Ligand; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Vitamin B Complex; X-Ray Microtomography | 2012 |
Drug-drug interaction between methotrexate and levetiracetam in a child treated for acute lymphoblastic leukemia.
Topics: Adolescent; Anticonvulsants; Antineoplastic Agents; Drug Interactions; Drug Therapy, Combination; Humans; Levetiracetam; Male; Methotrexate; Piracetam; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures | 2013 |
Overexpression of the mitochondrial folate and glycine-serine pathway: a new determinant of methotrexate selectivity in tumors.
Topics: Biological Transport; Folic Acid; Folic Acid Antagonists; Glycine; Humans; Methotrexate; Mitochondria; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Serine; Transcriptome | 2013 |
[Adverse effects of methotrexate in the treatment of acute lymphoblastic leukemia in Uyghur and Han children].
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; China; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
'Stroke-like syndrome' caused by intrathecal methotrexate in patients treated during the UKALL 2003 trial.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Female; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stroke; United Kingdom | 2013 |
Intellectual functioning of childhood leukemia survivors--relation to Tau protein--a marker of white matter injury.
Topics: Adolescent; Antineoplastic Agents; Biomarkers; Brain Injuries; Child; Child, Preschool; Cognition Disorders; Female; Humans; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; tau Proteins | 2012 |
C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: effect on methotrexate-related toxicity in adult acute lymphoblastic leukaemia.
Topics: Adult; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Real-Time Polymerase Chain Reaction | 2013 |
Chemotherapy for initial induction failures in childhood acute lymphoblastic leukemia: a Children's Oncology Group Study (POG 8764).
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Hydrocortisone; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Teniposide; Treatment Outcome; Young Adult | 2013 |
Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Biomarkers, Tumor; Child; Female; Haplotypes; Humans; Male; Methotrexate; Multidrug Resistance-Associated Protein 2; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies | 2013 |
[Treatment outcome of non-Hodgkin lymphoma in childhood: KYCCSG NHL-89, 96].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2012 |
The evaluation of protein Z levels of children with acute lymphoblastic leukaemia during induction therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blood Proteins; Case-Control Studies; Child; Child, Preschool; Daunorubicin; Female; Hemorrhage; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Thrombosis; Time Factors; Vincristine | 2013 |
Hypopyon as the first sign of relapse in acute lymphoblastic leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Cyclophosphamide; Cytarabine; Doxorubicin; Eye Neoplasms; Fatal Outcome; Female; Humans; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Vincristine | 2013 |
Bone mineral assessment with tibial ultrasonometry and dual-energy X-ray absorptiometry in long-term survivors of acute lymphoblastic leukemia in childhood.
Topics: Absorptiometry, Photon; Adolescent; Adrenal Cortex Hormones; Adult; Antimetabolites, Antineoplastic; Bone Density; Bone Diseases; Child; Cross-Sectional Studies; Disease-Free Survival; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tibia; Ultrasonography | 2002 |
Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity.
Topics: Antimetabolites, Antineoplastic; Child; Female; gamma-Glutamyl Hydrolase; Humans; Infusions, Intravenous; Male; Methotrexate; Models, Theoretical; Neoplasm Proteins; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2002 |
Treatment of Czech children with acute lymphoblastic leukemia: a report of the Czech Working Group for Pediatric Hematology.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Czech Republic; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Immunophenotyping; Infant; Male; Methotrexate; Ploidies; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2002 |
Symptomatic hypoglycemia in children receiving oral purine analogues for treatment of childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blood Glucose; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Hypoglycemia; Italy; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Purines; Retrospective Studies; Time Factors; Vincristine | 2002 |
Variant translocations of 11q23 in infant acute lymphoblastic leukemia (ALL): do outcomes differ from t(4;11)?
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 4; Cyclophosphamide; Cytarabine; Cytogenetic Analysis; Daunorubicin; DNA Primers; Female; Humans; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Translocation, Genetic; Vincristine | 2002 |
Increased factor VIII activity and dural sinus thrombosis.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Factor VIII; Humans; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiography; Risk Factors; Sagittal Sinus Thrombosis; Vincristine | 2002 |
Primary cutaneous lymphoblastic lymphoma presenting in an 8-week old infant.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Humans; Immunohistochemistry; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Neoplasms; Vincristine | 2002 |
The role of posttransplantation maintenance chemotherapy in improving the outcome of autotransplantation in adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Disease-Free Survival; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Secondary Prevention; Survival Analysis; Transplantation, Autologous; Vincristine | 2002 |
A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Azathioprine; Bone Marrow Transplantation; Cyclophosphamide; Daunorubicin; Drug Therapy, Combination; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Living Donors; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Tacrolimus; Transplantation Conditioning; Transplantation, Homologous; Vincristine | 2002 |
Improvement over time in outcome for children with acute lymphoblastic leukemia in second remission given hematopoietic stem cell transplantation from unrelated donors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; DNA, Neoplasm; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; HLA-A Antigens; HLA-B Antigens; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Infant; Living Donors; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Registries; Remission Induction; Survival Rate; Time Factors; Transplantation, Homologous; Treatment Outcome; Vincristine | 2002 |
Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Carrier Proteins; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Folate Receptors, GPI-Anchored; Genotype; Humans; Infant; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Treatment Outcome | 2002 |
Subacute leukencephalopathy after low-dose intrathecal methotrexate in an adolescent heterozygous for the MTHFR C677T polymorphism.
Topics: Adolescent; Antimetabolites, Antineoplastic; Heterozygote; Humans; Injections, Spinal; Leukoencephalitis, Acute Hemorrhagic; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2003 |
Post-induction residual disease in translocation t(12;21)-positive childhood ALL.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 21; Core Binding Factor Alpha 2 Subunit; DNA Primers; Doxorubicin; Female; Humans; Immunophenotyping; Infant; Male; Methotrexate; Neoplasm, Residual; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Translocation, Genetic; Vincristine | 2003 |
Perfusion MRI and SPECT of brain after treatment for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Child; Child, Preschool; Cytarabine; Female; Humans; Iatrogenic Disease; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon; Vincristine | 2003 |
Long-term cognitive outcome, brain computed tomography scan, and magnetic resonance imaging in children cured for acute lymphoblastic leukemia.
Topics: Antibiotic Prophylaxis; Antimetabolites, Antineoplastic; Atrophy; Brain; Brain Neoplasms; Child; Child, Preschool; Cognition Disorders; Female; Follow-Up Studies; Humans; Infant; Infusions, Intravenous; Intelligence Tests; Magnetic Resonance Imaging; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Radiotherapy, Adjuvant; Survival Rate; Tomography, X-Ray Computed | 2002 |
Treatment: the most important prognostic variable.
Topics: Antineoplastic Agents; Diploidy; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Treatment Outcome | 2002 |
Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dental Enamel Hypoplasia; Dexamethasone; Doxorubicin; Etoposide; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Odontogenesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Teniposide; Tooth Abnormalities; Tooth Diseases; Tooth Eruption; Tooth Root; Vincristine | 2003 |
Transplantation of peripheral blood stem cells as compared with bone marrow from HLA-identical siblings in adult patients with acute myeloid leukemia and acute lymphoblastic leukemia.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Bone Marrow Transplantation; Chronic Disease; Disease-Free Survival; Female; Graft vs Host Disease; HLA Antigens; Humans; Immunosuppressive Agents; Leukemia, Myelomonocytic, Acute; Male; Methotrexate; Multivariate Analysis; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2002 |
[Primary renal non-Hodgkin lymphoma].
Topics: Abdominal Pain; Acute Kidney Injury; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Bone Marrow Examination; Cyclophosphamide; Female; Humans; Hydrocortisone; Kidney Neoplasms; Methotrexate; Methylprednisolone; Nausea; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Renal Dialysis; Treatment Outcome; Vincristine; Vomiting | 2002 |
Posterior leukoencephalopathy following intrathecal chemotherapy with MRA-documented vasospasm.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Blindness; Brain Diseases; Cerebral Arteries; Cerebral Infarction; Cytarabine; Disease Progression; Female; Humans; Injections, Spinal; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Methotrexate; Middle Aged; Ocular Motility Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recovery of Function; Syndrome; Tachycardia; Vasospasm, Intracranial | 2003 |
Benign intracranial hypertension in association with acute lymphoblastic leukemia.
Topics: Acetazolamide; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Chlorthalidone; Cyclophosphamide; Cytarabine; Daunorubicin; Diagnosis, Differential; Headache; Humans; Intracranial Hypertension; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Sinus Thrombosis, Intracranial; Vincristine; Vomiting | 2003 |
[Ocular relapse of acute lymphoblastic leukemia].
Topics: Administration, Topical; Adrenal Cortex Hormones; Anterior Chamber; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cyclophosphamide; Cytarabine; Dexamethasone; Eye Neoplasms; Fatal Outcome; Humans; Methotrexate; Neoplasm Recurrence, Local; Paracentesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Vincristine | 2002 |
Systemic methotrexate exposure is greater after intrathecal than after oral administration.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Child, Preschool; Confidence Intervals; Erythrocytes; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2003 |
Treatment of acute lymphoblastic leukemia in Hong Kong children: HKALL 93 study.
Topics: Adolescent; Age Factors; Central Nervous System Neoplasms; Child; Child, Preschool; Disease-Free Survival; Female; Hong Kong; Humans; Immunophenotyping; Infant; Logistic Models; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Regression Analysis; Salvage Therapy; Time Factors | 2003 |
Successful reintroduction of methotrexate after acute pneumonitis in a patient with acute lymphoblastic leukemia.
Topics: Acute Disease; Female; Humans; Mercaptopurine; Methotrexate; Middle Aged; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Tomography, X-Ray Computed | 2003 |
Methotrexate-induced acral erythema with bullous reaction.
Topics: Adolescent; Erythema; Humans; Male; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin; Skin Diseases, Vesiculobullous | 2003 |
Induction of long-term remission of a relapsed childhood B-acute lymphoblastic leukemia with rituximab chimeric anti-CD20 monoclonal antibody and autologous stem cell transplantation.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Burkitt Lymphoma; Child; Combined Modality Therapy; Cytarabine; Dexamethasone; Etoposide; Humans; Immunotherapy; Leukemic Infiltration; Male; Meninges; Methotrexate; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Rituximab; Salvage Therapy; Testis; Topotecan; Transplantation, Autologous; Vindesine | 2003 |
Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Gene Expression; Gene Expression Profiling; Humans; Mercaptopurine; Methotrexate; Oligonucleotide Array Sequence Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 2003 |
Intrathecal methotrexate-induced acute cerebellar syndrome.
Topics: Acute Disease; Adult; Antimetabolites, Antineoplastic; Cerebellar Diseases; Critical Care; Female; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2003 |
High-dose methotrexate: on the relationship of methotrexate elimination time vs renal function and serum methotrexate levels in 1164 courses in 264 Swedish children with acute lymphoblastic leukaemia (ALL).
Topics: Adolescent; Child; Child, Preschool; Creatinine; Female; Humans; Infant; Kidney; Kidney Function Tests; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Urinalysis | 2003 |
Imatinib Mesylate (Gleevec) is a useful agent in the salvage treatment of adults with relapsed/refractory Philadelphia positive acute leukemias.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamides; Cytarabine; Daunorubicin; Doxorubicin; Enzyme Inhibitors; Female; Fusion Proteins, bcr-abl; Hepatitis B; Humans; Imatinib Mesylate; Immunosuppressive Agents; Lamivudine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Peripheral Blood Stem Cell Transplantation; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pyrimidines; Remission Induction; Salvage Therapy; Vincristine | 2003 |
Transient encephalopathy following high-dose methotrexate.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain Diseases; Drug Administration Schedule; Female; Humans; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2003 |
[The influence of age, gender and modifications of therapeutic protocols on physical development of children and adolescents after completion of therapy for acute lymphoblastic leukemia].
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Mass Index; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Female; Growth; Humans; Longitudinal Studies; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Retrospective Studies; Risk Factors; Sex Factors; Thioguanine; Vincristine | 2003 |
Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Case-Control Studies; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Genes, MDR; Humans; Hydroxyurea; Male; Mercaptopurine; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured; Vincristine | 2003 |
Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia.
Topics: Carrier Proteins; Child; Homocysteine; Humans; Hyperhomocysteinemia; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2003 |
[Human leukocyte antigen mismatched hemopietic stem cell transplants for the treatment of leukemia].
Topics: Bone Marrow Transplantation; Cyclophosphamide; Cyclosporine; Graft vs Host Disease; Granulocyte Colony-Stimulating Factor; Histocompatibility Antigens Class II; HLA Antigens; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Methotrexate; Mycophenolic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stem Cell Transplantation; Transplantation Conditioning; Transplantation, Homologous | 2003 |
Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Carrier Proteins; Child; Child, Preschool; Disease-Free Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Folate Receptors, GPI-Anchored; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Infant; Male; Methotrexate; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proliferating Cell Nuclear Antigen; Receptors, Cell Surface; Tetrahydrofolate Dehydrogenase | 2003 |
Lymphoblastic lymphoma of childhood and the LSA2-L2 protocol: the 30-year experience at Memorial-Sloan-Kettering Cancer Center.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Disease-Free Survival; Female; Follow-Up Studies; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Radiotherapy Dosage; Survival Rate; Treatment Outcome; Vincristine | 2003 |
SERUM COMPLEMENT LEVELS IN CHILDREN WITH ACUTE LYMPHOCYTIC LEUKEMIA.
Topics: Adolescent; Antineoplastic Agents; Blood; Child; Complement System Proteins; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Serologic Tests; Spectrophotometry; Thioguanine | 1964 |
INTRACRANIAL EXTRACEREBRAL HEMORRHAGES IN ACUTE LYMPHOCYTIC LEUKEMIA. A PROBLEM RESULTING FROM THE CHEMOTHERAPEUTIC MODIFICATIONS OF ACUTE LEUKEMIA.
Topics: Adolescent; Child; Hematoma; Hematoma, Epidural, Cranial; Hematoma, Subdural; Humans; Hydrocephalus; Leucovorin; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Meninges; Mercaptopurine; Methotrexate; Pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiography; Subarachnoid Hemorrhage; Vinblastine | 1964 |
Simultaneous determination of methotrexate and its eight metabolites in human whole blood by capillary zone electrophoresis.
Topics: Antimetabolites, Antineoplastic; Electrophoresis, Capillary; Folic Acid Antagonists; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Neurotoxicity of intrathecal methotrexate: MR imaging findings.
Topics: Acute Disease; Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Edema; Diffusion Magnetic Resonance Imaging; Female; Humans; Injections, Spinal; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2003 |
Bone marrow stroma damage induced by chemotherapy for acute lymphoblastic leukemia in children.
Topics: Antibodies; Antigens, CD34; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Child; Chronic Disease; Coculture Techniques; Cytokines; Erythroid Precursor Cells; Humans; Macrophage Inflammatory Proteins; Mercaptopurine; Methotrexate; Myeloid Progenitor Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stromal Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
White matter and cerebral metabolite changes in children undergoing treatment for acute lymphoblastic leukemia: longitudinal study with MR imaging and 1H MR spectroscopy.
Topics: Adolescent; Brain; Brain Chemistry; Child; Child, Preschool; Female; Humans; Infant; Longitudinal Studies; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 2003 |
Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Case-Control Studies; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Leukemic; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Protein Isoforms; Receptors, Glucocorticoid; Treatment Outcome; Vincristine | 2003 |
Role of macrophages and stellate cells in the pathogenesis of veno-occlusive disease: an electron microscopic case study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Female; Hepatic Veno-Occlusive Disease; Humans; Liver; Macrophages; Mercaptopurine; Methotrexate; Microscopy, Electron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 2003 |
Pegylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukaemia in first remission: a pilot study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Asparagine; Blood Coagulation; Drug Administration Schedule; Female; Humans; Liver; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 2003 |
Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge.
Topics: Adolescent; Anaphylaxis; Anti-Allergic Agents; Antimetabolites, Antineoplastic; Antipruritics; Diphenhydramine; Dose-Response Relationship, Drug; Drug Eruptions; Drug Therapy, Combination; Histamine H2 Antagonists; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pruritus; Ranitidine; Skin Tests; Urticaria | 2003 |
Impact of CNS treatment on mood in adult survivors of childhood leukemia: a report from the Children's Cancer Group.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Behavior; Brain Diseases; Case-Control Studies; Child; Cranial Irradiation; Female; Humans; Male; Methotrexate; Mood Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stress, Psychological; Surveys and Questionnaires; Survivors; Treatment Outcome | 2003 |
Outcome of children with high-risk acute lymphoblastic leukemia (HR-ALL): Nordic results on an intensive regimen with restricted central nervous system irradiation.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Child; Child, Preschool; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Stem Cell Transplantation; Transplantation, Homologous; Treatment Outcome | 2004 |
CNS-directed therapy in young children with T-lineage acute lymphoblastic leukemia: High-dose methotrexate versus cranial irradiation.
Topics: Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child, Preschool; Cohort Studies; Cranial Irradiation; Female; Humans; Infant; Leukemia, T-Cell; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Survival Rate | 2004 |
Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies.
Topics: Adolescent; Animals; Antineoplastic Agents; Child; Child, Preschool; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Gene Rearrangement, T-Lymphocyte; Genes, Immunoglobulin; Humans; Immunophenotyping; Male; Methotrexate; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Heterologous; Treatment Outcome; Vincristine | 2004 |
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Blotting, Northern; Carrier Proteins; Child; DNA Mutational Analysis; Drug Resistance, Neoplasm; Humans; Membrane Transport Proteins; Methotrexate; Osteosarcoma; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Tumor Cells, Cultured | 2004 |
Neurotoxicity marker profiles in the CSF are not age-dependent but show variation in children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Chi-Square Distribution; Child; Child, Preschool; Female; Humans; Infant; Linear Models; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Statistics, Nonparametric; tau Proteins | 2004 |
Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Hyperglycemia; Infections; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Time Factors; Vincristine | 2004 |
Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity.
Topics: Alanine Transaminase; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Activation; Female; Humans; Liver; Liver Function Tests; Male; Maximum Tolerated Dose; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Probability; Risk Assessment; Severity of Illness Index | 2004 |
Isolated central nervous system relapse in lymphoid blast crisis chronic myeloid leukemia and acute lymphoblastic leukemia in patients on imatinib therapy.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Benzamides; Blast Crisis; Bone Marrow; Central Nervous System Neoplasms; Cytarabine; Female; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methotrexate; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recurrence; Remission Induction | 2004 |
Late-onset delayed excretion of methotrexate.
Topics: Adolescent; Antimetabolites, Antineoplastic; Ascites; Humans; Male; Methotrexate; Pleural Effusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency | 2004 |
Methotrexate-induced leukoencephalopathy reversed by aminophylline and high-dose folinic acid.
Topics: Adult; Aminophylline; Brain Diseases; Female; Humans; Leucovorin; Magnetic Resonance Imaging; Methotrexate; Neurotoxicity Syndromes; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2004 |
Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.
Topics: Adult; Antimetabolites, Antineoplastic; Encephalomyelitis; Fatal Outcome; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
High-dose methotrexate and asparaginase for the treatment of children with acute lymphoblastic leukemia: why and how?
Topics: Antineoplastic Agents; Asparaginase; Child; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia: an unusual case marked by delayed perforation of the descending colon.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Colostomy; Enterocolitis, Neutropenic; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Intestinal Perforation; Laparotomy; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Vincristine | 2004 |
Prolonged fever of unknown origin and hemophagocytosis evolving into acute lymphoblastic leukemia.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Cytarabine; Disease Progression; Doxorubicin; Fever of Unknown Origin; Histiocytosis, Non-Langerhans-Cell; Humans; Karyotyping; Male; Methotrexate; Middle Aged; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Rituximab; Splenomegaly; Vincristine | 2004 |
A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells.
Topics: Catalysis; Cloning, Molecular; Diploidy; gamma-Glutamyl Hydrolase; Humans; Kinetics; Methotrexate; Mutagenesis, Site-Directed; Polyglutamic Acid; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Substrate Specificity | 2004 |
Primary acute lymphoblastic leukemia cells use a novel promoter and 5'noncoding exon for the human reduced folate carrier that encodes a modified carrier translated from an upstream translational start.
Topics: 5' Untranslated Regions; Base Sequence; Blotting, Northern; Blotting, Western; Cell Line, Tumor; DNA, Complementary; Exons; Gene Deletion; Genes, Reporter; Genotype; Humans; Jurkat Cells; K562 Cells; Kinetics; Luciferases; Membrane Transport Proteins; Methotrexate; Microscopy, Confocal; Models, Genetic; Molecular Sequence Data; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Protein Biosynthesis; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA Processing, Post-Transcriptional; RNA, Messenger; Time Factors; Transcription, Genetic | 2004 |
Methotrexate inhibits the glyoxalase system in vivo in children with acute lymphoid leukaemia.
Topics: Antimetabolites, Antineoplastic; Child; Enzyme Inhibitors; Female; Humans; Lactoylglutathione Lyase; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
Pleomorphic adenoma of the lacrimal gland in a child after treatment of acute lymphoblastic leukemia.
Topics: Adenoma, Pleomorphic; Adolescent; Antibiotics, Antineoplastic; Cyclophosphamide; Doxorubicin; Eye Neoplasms; Female; Humans; Immunosuppressive Agents; Lacrimal Apparatus; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
Unexpected response of hormone-refractory prostate cancer to treatment with an antileukemic chemotherapy regimen.
Topics: Adenocarcinoma; Anilides; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Fatal Outcome; Goserelin; Humans; Immunocompromised Host; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Neoplasms, Second Primary; Neutropenia; Nitriles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostate-Specific Antigen; Prostatic Neoplasms; Recurrence; Sepsis; Tosyl Compounds; Vincristine | 2004 |
Treatment of accidental intrathecal methotrexate overdose with intrathecal carboxypeptidase G2.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Clinical Trials as Topic; Drainage; Drug Overdose; Female; gamma-Glutamyl Hydrolase; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Male; Medication Errors; Methotrexate; Middle Aged; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins | 2004 |
[Methotrexate-induced interstitial pneumonitis in a child with acute lymphoblastic leukemia].
Topics: Antimetabolites, Antineoplastic; Child, Preschool; Humans; Lung Diseases, Interstitial; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
[Mismatched hematopoietic stem cell transplantation using GIAC protocol: report of 100 cases].
Topics: Adolescent; Adult; Antilymphocyte Serum; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Female; Graft vs Host Disease; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Histocompatibility Testing; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Mycophenolic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Homologous | 2004 |
Improving the segmentation of therapy-induced leukoencephalopathy in children with acute lymphoblastic leukemia using a priori information and a gradient magnitude threshold.
Topics: Adolescent; Algorithms; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2004 |
The analysis of correlations between drug resistance and clinical/laboratory measures found in a group of children with all treated by ALL-BFM 90 protocol.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Coloring Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Resistance, Neoplasm; Female; Humans; In Vitro Techniques; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Remission Induction; Sex Factors; Tetrazolium Salts; Thiazoles; Vincristine | 2004 |
[Primary study of relationship between serum level of VEGF and non-Hodgkin's lymphoma in children and adolescent patients].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vascular Endothelial Growth Factor A; Vincristine | 2004 |
Oxidative changes in cerebral spinal fluid phosphatidylcholine during treatment for acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Injections, Spinal; Lipid Peroxidation; Male; Methotrexate; Oxidative Stress; Phosphatidylcholines; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
[Efficacy of modified BFM-90 regimen on children and adolescents with T cell lymphoblastic lymphoma: a report of 20 cases].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Follow-Up Studies; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Stem Cell Transplantation; Survival Rate; Treatment Outcome; Vincristine | 2004 |
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.
Topics: Cluster Analysis; DNA; Folic Acid; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Leukocyte Count; Lymphocytes; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Messenger; Thymidylate Synthase | 2005 |
[Immunologic monitoring in children with acute lymphoblastic leukemia during maintenance treatment with regard to co-existing infections].
Topics: Adolescent; Antigens; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Flow Cytometry; Humans; Immunoglobulins; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Monitoring, Immunologic; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Statistics, Nonparametric; Thioguanine; Time Factors; Vincristine | 2004 |
Images in haematology. Combined central retinal artery and vein occlusions as the presenting signs of ocular relapse in acute lymphoblastic leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Leukemic Infiltration; Methotrexate; Middle Aged; Ophthalmoscopy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retinal Artery Occlusion; Retinal Vein Occlusion | 2005 |
[Treatment results in children with standard-risk acute lymphoblastic leukemia. Report of the Polish Pediatric Leukemia/Lymphoma Study Group].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Bone Neoplasms; Central Nervous System Neoplasms; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Infant, Newborn; Male; Mercaptopurine; Methotrexate; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Retrospective Studies; Risk Factors; Secondary Prevention; Survival Analysis; Testicular Neoplasms; Time Factors; Treatment Outcome; Vincristine | 2004 |
Interference of 7-hydroxymethotrexate with the determination of methotrexate in plasma samples from children with acute lymphoblastic leukemia employing routine clinical assays.
Topics: Child; Chromatography, High Pressure Liquid; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sensitivity and Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 2005 |
Second induction in pediatric patients with recurrent acute lymphoid leukemia using DFCI-ALL protocols.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Doxorubicin; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Retrospective Studies; Stem Cell Transplantation; Survival Analysis; Transplantation, Homologous; Treatment Outcome; Vincristine | 2005 |
Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects.
Topics: Child; Child, Preschool; Female; Folic Acid Antagonists; Genotype; Humans; Male; Methotrexate; Methyltransferases; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Trimethoprim | 2005 |
Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia.
Topics: Alleles; Antimetabolites, Antineoplastic; Case-Control Studies; Child, Preschool; Female; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Cognitive changes in children treated for acute lymphoblastic leukemia with chemotherapy only according to the Pediatric Oncology Group 9605 protocol.
Topics: Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Cognition Disorders; Cohort Studies; Cytarabine; Female; Hematinics; Humans; Hydrocortisone; Leucovorin; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Wechsler Scales | 2005 |
Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Drug Resistance, Neoplasm; Ferredoxin-NADP Reductase; Folic Acid; Genetic Variation; Glycine Hydroxymethyltransferase; Humans; In Vitro Techniques; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Effects and interaction of 7-hydroxy methotrexate and methotrexate in leukaemic cells ex vivo measured by the thymidylate synthase inhibition assay.
Topics: Antimetabolites, Antineoplastic; Drug Interactions; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase; Tumor Cells, Cultured | 2005 |
Kernohan notch lesion after spinal tap.
Topics: Adult; Causality; Cerebral Veins; Disease Progression; Efferent Pathways; Female; Headache; Hematoma, Subdural, Intracranial; Hemiplegia; Humans; Injections, Spinal; Intracranial Hypotension; Magnetic Resonance Imaging; Mesencephalon; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Puncture; Thrombocytopenia | 2005 |
Myelopathy due to intrathecal chemotherapy: report of six cases.
Topics: Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Folic Acid Antagonists; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases | 2005 |
[Leucovorin rescue after continuing infusion of high dose methotrexate].
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Transient encephalopathy after intrathekal methotrexate chemotherapy: diffusion-weighted MRI.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child; Diffusion Magnetic Resonance Imaging; Humans; Injections, Spinal; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Treatment Outcome | 2005 |
[Study on elimination delay in high dose methotrexate therapy in childhood acute lymphoblastic leukemia].
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Nausea; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Treatment Outcome; Vomiting; Young Adult | 2005 |
Nuclear winter.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Child, Preschool; Humans; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate.
Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases, Metabolic; Child; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Pharmacodynamic properties of methotrexate and Aminotrexate during weekly therapy.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Folic Acid Antagonists; Humans; Infant; Male; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tissue Distribution | 2006 |
Central nervous system chemoprophylaxis in non-Hodgkin lymphoma: current practice in the UK.
Topics: Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Neoplasms; Chemoprevention; Humans; Lymphoma, Non-Hodgkin; Methotrexate; Patient Selection; Practice Patterns, Physicians'; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Surveys and Questionnaires; United Kingdom | 2005 |
A quantitative MR imaging assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation.
Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child; Child, Preschool; Humans; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Brain white matter changes during treatment of a child for acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia.
Topics: AC133 Antigen; Amphotericin B; Antifungal Agents; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Caspofungin; Child; Combined Modality Therapy; Contraindications; Dexamethasone; Drug Therapy, Combination; Echinocandins; Glycoproteins; Humans; Immunomagnetic Separation; Lipopeptides; Male; Mercaptopurine; Methotrexate; Peptides; Peptides, Cyclic; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recurrence; Remission Induction; Salvage Therapy; Transplantation, Autologous; Transplantation, Homologous; Triazoles; Vincristine; Voriconazole; Zygomycosis | 2007 |
Whole brain magnetization transfer histogram analysis of pediatric acute lymphoblastic leukemia patients receiving intrathecal methotrexate therapy.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child; Child, Preschool; Feasibility Studies; Humans; Infant; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 2006 |
Acute pseudobulbar palsy due to methotrexate with rapid response to intravenous immunoglobulin.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Humans; Immunoglobulins, Intravenous; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pseudobulbar Palsy; Radiography | 2005 |
p16 inactivation associated with aggressive clinical course and fatal outcome in TEL/AML1-positive acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Chromosomes, Human, Pair 9; Combined Modality Therapy; Core Binding Factor Alpha 2 Subunit; Cyclin-Dependent Kinase Inhibitor p16; Cyclophosphamide; Cytarabine; Daunorubicin; Fatal Outcome; Gene Deletion; Genes, p16; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Proteins; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Vincristine | 2005 |
Reversible acute methotrexate leukoencephalopathy: atypical brain MR imaging features.
Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Child; Child, Preschool; Contrast Media; Female; Humans; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2006 |
Erythrocyte concentrations of metabolites or cumulative doses of 6-mercaptopurine and methotrexate do not predict liver changes in children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Monitoring; Erythrocytes; Female; Humans; Liver Cirrhosis; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Statistics, Nonparametric | 2006 |
Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Etoposide; Female; Humans; Male; Mercaptopurine; Methotrexate; Patient Selection; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Randomized Controlled Trials as Topic; Remission Induction; Research Design; Survival Analysis; Thioguanine; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome; Vincristine | 2007 |
The old grey mare, she ain't what she used to be. Is she?: (commentary on Kaspers et al., page 539).
Topics: Child; Clinical Trials, Phase II as Topic; Drug Resistance, Neoplasm; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recurrence; Treatment Failure; Treatment Outcome | 2006 |
Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vitamin B 12; Vitamin B Complex | 2006 |
Polyuria associated with high-dose methotrexate in two patients with acute lymphoblastic leukaemia.
Topics: Adenosine; Adolescent; Antimetabolites, Antineoplastic; Child; Diabetes Insipidus, Nephrogenic; Female; Fluid Therapy; Humans; Injections, Intravenous; Male; Methotrexate; Polyuria; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2005 |
Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma.
Topics: Adolescent; Alleles; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genetic Variation; Hematologic Diseases; Humans; Infant; Japan; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Stomatitis | 2006 |
bcr-abl-positive T-cell acute lymphoblastic leukemia associated with parvovirus B19 infection.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Cerebral Hemorrhage; Combined Modality Therapy; Disseminated Intravascular Coagulation; Fatal Outcome; Fusion Proteins, bcr-abl; Genes, abl; Hematopoietic Stem Cell Transplantation; Humans; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Multiple Organ Failure; Neoplasm Proteins; Pancytopenia; Parvoviridae Infections; Parvovirus B19, Human; Philadelphia Chromosome; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Preleukemia; Shock, Septic; Staphylococcal Infections; Vincristine | 2006 |
Roles of protein C, protein S, and antithrombin III in acute leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antithrombin III; Asparaginase; Cyclophosphamide; Cytarabine; Disseminated Intravascular Coagulation; Female; Humans; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Myocardial Infarction; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Protein C; Protein S; Thrombosis; Vincristine | 2006 |
Outcome of treatment in adults with Philadelphia chromosome-positive and/or BCR-ABL--positive acute lymphoblastic leukemia-retrospective analysis of Polish Adult Leukemia Group (PALG).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Disease-Free Survival; Female; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mercaptopurine; Methotrexate; Middle Aged; Philadelphia Chromosome; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Treatment Outcome | 2006 |
MR imaging of the brain in patients cured of acute lymphoblastic leukemia--the value of gradient echo imaging.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Brain; Child; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 2006 |
5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism.
Topics: Aminoimidazole Carboxamide; Biological Transport; Cell Line, Tumor; Child; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid Antagonists; Humans; Kinetics; Leukemia, T-Cell; Membrane Transport Proteins; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Ribonucleotides; Subcellular Fractions; Temperature; Thymidylate Synthase; Tritium | 2006 |
Occurrence and impact of unanticipated variation in intravenous methotrexate dosing.
Topics: Antimetabolites, Antineoplastic; Child; Humans; Infusions, Intravenous; Medication Errors; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 2006 |
Central nervous system recurrence in adult patients with acute lymphoblastic leukemia: frequency and prognosis in 467 patients without cranial irradiation for prophylaxis.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Female; Humans; Hydrocortisone; Incidence; Lactate Dehydrogenases; Male; Methotrexate; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Factors; Survival Analysis | 2006 |
[Neurological complications during and after the treatment of acute lymphocytic leukemia].
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Cerebrovascular Disorders; Child; Child, Preschool; Cytarabine; Dementia, Vascular; Epilepsy; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Thiamine Deficiency; Wernicke Encephalopathy | 2006 |
Solid-phase extraction and large-volume sample stacking with an electroosmotic flow pump in capillary electrophoresis for determination of methotrexate and its metabolites in human plasma.
Topics: Antimetabolites, Antineoplastic; Buffers; Electrophoresis, Capillary; Humans; Infusion Pumps; Methotrexate; Monitoring, Physiologic; Phosphates; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2006 |
Acute lymphoblastic leukemia in adolescents between 10 and 19 years of age in Denmark--secondary publication.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Cyclophosphamide; Daunorubicin; Doxorubicin; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Retrospective Studies; Stem Cell Transplantation; Treatment Outcome; Vincristine | 2006 |
[Acute lymphoblastic leukaemia in Danish children and young people 10 to 19 years of age. Should young adults with acute lymphoblastic leukaemia be treated in the same way as children?].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Daunorubicin; Doxorubicin; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Radiotherapy, Adjuvant; Retrospective Studies; Stem Cell Transplantation; Treatment Outcome; Vincristine | 2006 |
Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate.
Topics: Adolescent; Algorithms; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Diagnosis, Computer-Assisted; Diagnosis, Differential; Female; Humans; Image Processing, Computer-Assisted; Infant; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2006 |
Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells.
Topics: Adolescent; Adult; Child; Child, Preschool; DNA Methylation; Enzyme Activation; Epigenesis, Genetic; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 2006 |
Reduction in bioavailability of 6-mercaptopurine on simultaneous administration with cow's milk.
Topics: Animals; Antineoplastic Agents; Biological Availability; Child, Preschool; Humans; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Milk; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2006 |
Folate cycle gene variants and chemotherapy toxicity in pediatric patients with acute lymphoblastic leukemia.
Topics: Child; Disease-Free Survival; Folic Acid; Folic Acid Antagonists; Hematologic Diseases; Humans; Liver; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2006 |
[Treatment results in children with the standard risk acute lymphoblastic leukemia treated with high dose of methotrexate (5.0 g/m2). 11 years of the Polish Pediatric Leukemia/Lymphoma Study Group experience].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cohort Studies; Disease-Free Survival; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Methotrexate; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Treatment Outcome | 2006 |
[Acute lymphoblastic leukemia in children with initial leucocytosis above 50,000/mm3: summary of treatment results of Polish Pediatric Leukemia/Lymphoma Study Group].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Infant; Leukocyte Count; Leukocytosis; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Thioguanine; Treatment Outcome; Vincristine | 2006 |
Physical activity during treatment in children with leukemia: a pilot study.
Topics: Antineoplastic Agents; Child; Child, Preschool; Exercise; Female; Humans; Male; Mercaptopurine; Methotrexate; Motor Activity; Oxygen Consumption; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 2006 |
Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Dexamethasone; Humans; Infant; Medication Errors; Mercaptopurine; Methotrexate; Outpatients; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Thioguanine | 2006 |
Prevention of oral lesions in children with acute lymphoblastic leukemia.
Topics: Adolescent; Anti-Infective Agents; Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Chlorhexidine; Female; Humans; Male; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis | 2006 |
Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Attention; Brain Neoplasms; Child, Preschool; Cognition; Cohort Studies; Cranial Irradiation; Dose Fractionation, Radiation; Educational Status; Female; Humans; Infant; Infusions, Intravenous; Intelligence Tests; Male; Memory; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2006 |
[Twenty years of treating childhood acute lymphoblastic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Etoposide; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Prognosis; Recurrence; Risk Factors; Survival Rate; Time Factors; Vincristine | 2006 |
High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Case-Control Studies; Child; Child, Preschool; Disease-Free Survival; Drug Interactions; Female; Humans; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Registries; Risk Factors; Secondary Prevention; Vitamin B Complex | 2006 |
Therapeutic responses in childhood acute lymphoblastic leukemia (ALL) and haplotypes of gamma glutamyl hydrolase (GGH) gene.
Topics: gamma-Glutamyl Hydrolase; Haplotypes; Humans; Methotrexate; Polyglutamic Acid; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Disseminated necrotizing leukoencephalopathy following chemoradiation therapy for acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Brain; Brain Diseases; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Magnetic Resonance Imaging; Methotrexate; Necrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed | 2006 |
DHFR and MSH3 co-amplification in childhood acute lymphoblastic leukaemia, in vitro and in vivo.
Topics: Cell Line, Transformed; Cell Line, Tumor; Child; DNA-Binding Proteins; Gene Amplification; Gene Dosage; Humans; Methotrexate; MutS Homolog 3 Protein; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase | 2007 |
Is mega dose of methotrexate beneficial to patients with acute lymphoblastic leukemia?
Topics: Central Nervous System; Central Nervous System Neoplasms; Child; Clinical Trials as Topic; Humans; Leucovorin; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recurrence; Risk | 2006 |
Dermal dendrocyte ballooning.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Dendritic Cells; Drug Eruptions; Humans; Keratinocytes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin | 2006 |
Reduced elimination of Methotrexate in an adult with trisomy 21 and acute lymphoblastic leukaemia.
Topics: Adult; Antimetabolites, Antineoplastic; Down Syndrome; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genotype; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Infant; Liver Diseases; Lymphoma; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 2007 |
Ultraviolet recall reaction after total body irradiation, etoposide, and methotrexate therapy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Etoposide; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Skin; Sunburn; Ultraviolet Rays; Whole-Body Irradiation | 2007 |
A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia.
Topics: Adolescent; Bayes Theorem; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Models, Theoretical; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sampling Studies | 2007 |
Myelopathy due to intrathecal chemotherapy: magnetic resonance imaging findings.
Topics: Adult; Antimetabolites, Antineoplastic; Cytarabine; Female; Humans; Injections, Spinal; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord; Spinal Cord Diseases | 2007 |
[Superior sagittal sinus thrombosis during remission induction therapy for acute lymphoblastic leukemia].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Cyclophosphamide; Cytarabine; Doxorubicin; Facial Paralysis; Humans; Injections, Spinal; Male; Methotrexate; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Risk Factors; Sagittal Sinus Thrombosis; Vincristine | 2006 |
Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biological Transport; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Female; Gene Expression Regulation, Neoplastic; Humans; Infant; Male; Membrane Transport Proteins; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Ancestry and pharmacogenetics of antileukemic drug toxicity.
Topics: Antineoplastic Agents; Child; Drug-Related Side Effects and Adverse Reactions; Genotype; Humans; Methotrexate; Models, Biological; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Racial Groups; Remission Induction | 2007 |
[Reults of treatment with protocols BFM 90 and BFM 95].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Survival Rate; Vincristine | 2006 |
Transverse myelopathy following intrathecal administration of chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fatal Outcome; Hodgkin Disease; Humans; Injections, Spinal; Leukemic Infiltration; Male; Methotrexate; Myelitis, Transverse; Peripheral Blood Stem Cell Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Comparison of long-term neurocognitive outcomes in young children with acute lymphatic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate.
Topics: Child; Child, Preschool; Cognition; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Incidence; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Risk Assessment; Time Factors | 2007 |
Genetic polymorphisms of folate metabolic enzymes and toxicities of high dose methotrexate in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Folic Acid; Folic Acid Antagonists; Humans; Infant; Male; Methotrexate; Methyltransferases; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia.
Topics: Adolescent; B-Lymphocytes; Blast Crisis; CD11b Antigen; Cell Cycle; Cell Proliferation; Child; Child, Preschool; Female; Gene Expression Profiling; Humans; Infant; Interferon gamma Receptor; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Receptors, Interferon | 2007 |
[The clinical features of B cell lymphoblastic lymphoma and outcomes after BFM-90 regimen therapy].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Lymphoma, B-Cell; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2006 |
[High dose methotrexate induced acute renal insufficiency in a patient with acute lymphoblastic leukemia].
Topics: Acute Kidney Injury; Child; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia.
Topics: Adult; Child; Child, Preschool; Drug Resistance, Neoplasm; Ethnicity; Female; Genetic Predisposition to Disease; Humans; Indonesia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Netherlands; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Tandem Repeat Sequences; Thymidylate Synthase | 2008 |
Obesity in survivors of childhood acute lymphoblastic leukemia and lymphoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Body Mass Index; Child; Child, Preschool; Cranial Irradiation; Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Male; Methotrexate; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2007 |
[Complications in the central nervous system during chemotherapy for childhood acute lymphoblastic leukemia: JACLS ALL-02 study].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Diseases; Child; Child, Preschool; Female; Humans; Infant; Japan; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors | 2007 |
Triple intrathecal therapy without cranial irradiation for central nervous system preventive therapy in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System; Child; Child, Preschool; Cranial Irradiation; Cyclophosphamide; Cytarabine; Dexamethasone; Disease-Free Survival; Epirubicin; Female; Follow-Up Studies; Humans; Hydrocortisone; Infant; Injections, Spinal; Leukemic Infiltration; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Retrospective Studies; Risk; Survival Analysis; Vincristine | 2008 |
What is the best salvage therapy for treatment of isolated CNS relapse in elderly patients with imatinib-responsive Ph(+) ALL?
Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bone Marrow; Cytarabine; Humans; Hydrocortisone; Imatinib Mesylate; Injections, Spinal; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Radiotherapy; Salvage Therapy | 2007 |
Allogeneic bone marrow transplantation with total body irradiation-based conditioning in acute lymphoblastic leukemia patient with Cochlear implant.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow Transplantation; Cochlear Implantation; Cyclosporine; Follow-Up Studies; Graft vs Host Disease; Humans; Immunosuppressive Agents; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Time Factors; Transplantation, Homologous; Treatment Outcome; Whole-Body Irradiation | 2006 |
MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients.
Topics: Adolescent; Adult; Aged; Child; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Rate; Treatment Outcome | 2007 |
Motor and perceptual timing deficits among survivors of childhood leukemia.
Topics: Adult; Antimetabolites, Antineoplastic; Cerebellum; Child; Female; Frontal Lobe; Humans; Judgment; Male; Methotrexate; Motor Skills Disorders; Perceptual Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reaction Time; Survivors | 2007 |
Allogeneic transplantation for adult acute leukemia in first and second remission with a novel regimen incorporating daily intravenous busulfan, fludarabine, 400 CGY total-body irradiation, and thymoglobulin.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Antilymphocyte Serum; Antineoplastic Agents; Busulfan; Cyclosporine; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Infusions, Intravenous; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Myeloablative Agonists; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Stem Cell Transplantation; Survival Rate; Transplantation Conditioning; Transplantation, Homologous; Vidarabine; Whole-Body Irradiation | 2007 |
Biphenotypic acute leukaemia: a case series.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Humans; Immunophenotyping; Leukemia; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Vincristine | 2007 |
A 'pre-induction course' with non-cross-reacting cytostatic drugs for rapid tumour load reduction improves outcome in adult acute lymphoblastic leukaemia.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Cytarabine; Drug Therapy, Combination; Etoposide; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome; Tumor Burden | 2007 |
Vincristine-induced acute neurotoxicity versus Guillain-Barré syndrome: a diagnostic dilemma.
Topics: Action Potentials; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Dexamethasone; Diagnosis, Differential; Erectile Dysfunction; Fatal Outcome; Guillain-Barre Syndrome; Humans; Hydrocortisone; Male; Methotrexate; Paraparesis; Paresthesia; Polyradiculoneuropathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Urination Disorders; Vincristine | 2007 |
Induction of acute lymphocytic leukemia differentiation by maintenance therapy.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Clone Cells; Cytotoxins; Hematopoietic Stem Cells; Humans; Immunophenotyping; In Vitro Techniques; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Tretinoin | 2007 |
Disseminated intravascular coagulation in acute leukemia at presentation and during induction therapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Disseminated Intravascular Coagulation; Female; Humans; Incidence; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Partial Thromboplastin Time; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Vincristine | 2007 |
A paediatric case of Candida pericarditis and eosophagus stricture during treatment for acute lymphatic leukaemia.
Topics: Antineoplastic Agents; Candida albicans; Candidiasis; Child, Preschool; Doxorubicin; Esophageal Stenosis; Female; Humans; Immunosuppression Therapy; Methotrexate; Pericarditis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Risk Factors; Vincristine | 2007 |
A step forward in therapy for ALL in infants.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Infant; Infant, Newborn; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Randomized Controlled Trials as Topic | 2007 |
Methotrexate concentrations in cerebrospinal fluid and serum, and the risk of central nervous system relapse in children with acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Central Nervous System Neoplasms; Child; Child, Preschool; Female; Humans; Infant; Logistic Models; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk | 2007 |
Re: Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Encephalitis; Female; Humans; Injections, Spinal; Leukemic Infiltration; Liposomes; Male; Meninges; Meningitis; Methotrexate; Middle Aged; Papilledema; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures | 2007 |
L'asparaginase and methotrexate combinations: clashes of empiric success and laboratory models?
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Drug Synergism; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico.
Topics: Adolescent; Adult; Alleles; Antimetabolites, Antineoplastic; Child; Child, Preschool; Diet; Female; Folic Acid; Humans; Infant; Infant, Newborn; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Mucositis; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 2007 |
pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Clinical Protocols; Humans; Hydrogen-Ion Concentration; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Sodium Bicarbonate | 2007 |
Lipomembranous panniculitis in a patient with acute leukemia induced by chemotherapy.
Topics: Adipose Tissue; Adult; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Etoposide; Fat Necrosis; Female; Humans; Methotrexate; Panniculitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
Retrospective study on elimination delay of methotrexate in high-dose therapy of childhood acute lymphoblastic leukemia in China.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Interactions; Female; Fluid Therapy; Humans; Infant; Infusions, Intravenous; Liver; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2007 |
Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer.
Topics: Acute Disease; Adolescent; Aminophylline; Antimetabolites, Antineoplastic; Bone Neoplasms; Brain; Child; Diffusion Magnetic Resonance Imaging; Female; Histiocytoma, Malignant Fibrous; Humans; Injections, Intravenous; Injections, Spinal; Leukemia; Male; Metabolic Clearance Rate; Methotrexate; Neurotoxicity Syndromes; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 2008 |
Anterior lumbosacral polyradiculopathy after intrathecal administration of methotrexate.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Interactions; Fatal Outcome; Humans; Hydrocortisone; Injections, Spinal; Leg; Lumbosacral Plexus; Male; Methotrexate; Motor Neurons; Muscle, Skeletal; Neural Conduction; Paralysis; Paraparesis; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Respiratory Tract Infections; Sepsis; Spinal Nerve Roots; Urinary Bladder, Neurogenic | 2008 |
Neurochemical markers of brain damage in cerebrospinal fluid during induction treatment of acute lymphoblastic leukemia in children.
Topics: Adolescent; Antimetabolites, Antineoplastic; Biomarkers; Brain; Brain Damage, Chronic; Brain Injuries; Child; Child, Preschool; Dehydroascorbic Acid; Female; Glial Fibrillary Acidic Protein; Humans; Infant; Male; Methotrexate; Neurofilament Proteins; Phosphopyruvate Hydratase; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radioimmunoassay | 2008 |
Cytarabine induced noncardiogenic pulmonary edema in a case of acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Female; Glucocorticoids; Granulocyte Colony-Stimulating Factor; Humans; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Edema; Radiography; Vincristine | 2007 |
[Pharmacogenomics of acute lymphoblastic leukemia].
Topics: Antineoplastic Agents; Humans; Mercaptopurine; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
High-performance liquid chromatography separation of aminopterin-polyglutamates within red blood cells of children treated for acute lymphoblastic leukemia.
Topics: Administration, Oral; Adolescent; Adult; Aminopterin; Antineoplastic Agents; Child; Child, Preschool; Chromatography, High Pressure Liquid; Erythrocytes; Folic Acid Antagonists; Humans; Infant; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Standards; Tissue Distribution | 2007 |
Genetic and epigenetic alterations of the reduced folate carrier in untreated diffuse large B-cell lymphoma.
Topics: Adolescent; Adult; Biopsy; Child; Child, Preschool; Codon, Nonsense; DNA Methylation; DNA Mutational Analysis; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Membrane Transport Proteins; Methotrexate; Middle Aged; Mutation; Mutation, Missense; Point Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein | 2008 |
Atypical acute graft-versus-host disease.
Topics: Acute Disease; Adult; Bone Marrow Transplantation; Cyclosporine; Erythema; Graft vs Host Disease; Humans; Immunosuppressive Agents; Male; Methotrexate; Necrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Diseases; Treatment Outcome | 2007 |
Successful high-dose methotrexate chemotherapy in a patient with acute lymphocytic leukemia who developed acute renal failure during the initial treatment.
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Female; Humans; Infant; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2007 |
Bronchial asthma and acute lymphoblastic leukemia in childhood.
Topics: Acute Disease; Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Asthma; Drug Administration Schedule; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL.
Topics: Alleles; Antimetabolites, Antineoplastic; Cyclin D; Cyclins; Disease-Free Survival; DNA, Neoplasm; Female; Folic Acid; Haplotypes; Humans; Male; Methotrexate; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Survival Rate; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Transcription, Genetic | 2008 |
Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors.
Topics: Adult; Antimetabolites, Antineoplastic; Attention Deficit Disorder with Hyperactivity; Child; Female; Folic Acid Antagonists; Genetic Predisposition to Disease; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NAD+); Parents; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Surveys and Questionnaires; Survivors | 2008 |
Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity.
Topics: Adult; Brain Diseases; Diffusion Magnetic Resonance Imaging; Humans; Immunosuppressive Agents; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
[Accretion of bone mass in patients treated for childhood acute lymphoblastic leukemia].
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Case-Control Studies; Child; Child, Preschool; Cranial Irradiation; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2007 |
[Population pharmacokinetics of high-dose methotrexate administered in 329 children with acute lymphoblastic leukemia].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Male; Methotrexate; Models, Biological; Nonlinear Dynamics; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
Polymorphisms in folate-related genes: association with side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia.
Topics: Child; DNA Mutational Analysis; Folic Acid; Gene Frequency; Genotype; Humans; Metabolic Networks and Pathways; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
Interaction between methotrexate and omeprazole in an adolescent with leukemia: a case report.
Topics: Adolescent; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Humans; Male; Methotrexate; Omeprazole; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Ranitidine; Stomach Ulcer | 2008 |
Methotrexate-induced alterations in beta-oxidation correlate with cognitive abilities in children with acute lymphoblastic leukemia.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Child; Chromatography, Gas; Cognition Disorders; Female; Humans; Intelligence Tests; Male; Methotrexate; NAD; Oxidation-Reduction; Palmitic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Risk Factors; Statistics, Nonparametric; Stearic Acids | 2008 |
In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cohort Studies; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Infant; Kaplan-Meier Estimate; Male; Methotrexate; Neoplastic Cells, Circulating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2008 |
Association of plasma methotrexate, neutropenia, hepatic dysfunction, nausea/vomiting and oral mucositis in children with cancer.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Neoplasms; Chemical and Drug Induced Liver Injury; Child; Epidemiologic Methods; Female; Humans; Male; Methotrexate; Nausea; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stomatitis; Vomiting | 2008 |
Use of palifermin for the prevention of high-dose methotrexate-induced oral mucositis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fibroblast Growth Factor 7; Follow-Up Studies; Humans; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Pain Measurement; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Values; Retrospective Studies; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Stomatitis; Treatment Outcome | 2008 |
Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma.
Topics: Adolescent; Antineoplastic Agents; Carbon-Nitrogen Ligases; Child; Child, Preschool; Genotype; Humans; Mercaptopurine; Methotrexate; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 2008 |
Intravenous immunoglobulin in the treatment of severe methotrexate-induced acral erythema.
Topics: Adolescent; Antimetabolites, Antineoplastic; Diagnosis, Differential; Erythema; Foot Diseases; Hand Dermatoses; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2008 |
Treatment of high-risk acute lymphoblastic leukemia in children using the AL851 and ALHR88 protocols: a report from the Kyushu-Yamaguchi Children's Cancer Study Group in Japan.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Disease-Free Survival; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Vincristine | 1996 |
Peripheral blood progenitor cell transplantation in lymphoma and leukemia using a single apheresis.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Colony-Forming Units Assay; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Length of Stay; Leukapheresis; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Vincristine | 1993 |
[Pulmonary mucormycosis in leukemic patients. Apropos of 2 cases].
Topics: Adult; Aged; Amphotericin B; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Fatal Outcome; Granulocyte Colony-Stimulating Factor; Humans; Immunologic Factors; Itraconazole; Leukemia, Promyelocytic, Acute; Lung Diseases, Fungal; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Mucormycosis; Neutropenia; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1994 |
Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Erythrocytes; Female; Follow-Up Studies; Guanine Nucleotides; Humans; Infant; Male; Mercaptopurine; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Regression Analysis; Remission Induction; Risk; Thionucleotides; Time Factors | 1995 |
Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; Blood-Brain Barrier; Bone Marrow; Cell Movement; Central Nervous System; DNA, Neoplasm; Drug Evaluation, Preclinical; Immunotoxins; Injections, Intraperitoneal; Injections, Intravenous; Injections, Spinal; Leukemic Infiltration; Meninges; Methotrexate; Mice; Mice, SCID; N-Glycosyl Hydrolases; Neoplasm Transplantation; Neoplastic Cells, Circulating; Plant Proteins; Polymerase Chain Reaction; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ribosome Inactivating Proteins, Type 1; Specific Pathogen-Free Organisms; Transplantation, Heterologous | 1995 |
Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: implications for therapeutic management.
Topics: Adolescent; Bleomycin; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Iron; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies | 1995 |
Acute lymphoblastic leukemia in the elderly: results of two different treatment approaches in 49 patients during a 25-year period.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Daunorubicin; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Retrospective Studies; Treatment Outcome; Vincristine | 1995 |
Chemotherapy plays a major role in the inhibition of catch-up growth during maintenance therapy for childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Growth; Growth Disorders; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1995 |
[Electrolytic changes in children with acute lymphoblastic leukemia during remission induction].
Topics: Adolescent; Allopurinol; Anions; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Blood Urea Nitrogen; Cations; Child; Child, Preschool; Cohort Studies; Creatinine; Epirubicin; Female; Humans; Hydrocortisone; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Serum Albumin; Uric Acid; Vincristine; Water-Electrolyte Imbalance | 1995 |
Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission: factors predictive of survival, relapse and graft-versus-host disease.
Topics: Actuarial Analysis; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cause of Death; Child; Child, Preschool; Combined Modality Therapy; Cyclosporine; Cytarabine; Disease-Free Survival; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Male; Melphalan; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Survival Analysis; Treatment Outcome; Whole-Body Irradiation | 1995 |
An assay for the determination of reduced methotrexate accumulation in cells displaying limited viability in vitro.
Topics: Animals; Cryopreservation; Freezing; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidine; Tumor Cells, Cultured | 1995 |
CNS chemoradiotherapy of childhood leukemia: the plot thickens but the ending bodes well.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy; Recurrence; Sex Factors | 1995 |
Pubertal growth in young adult survivors of childhood leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Height; Brain Neoplasms; Child; Combined Modality Therapy; Cranial Irradiation; Daunorubicin; Female; Follow-Up Studies; Growth; Humans; Male; Menarche; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Puberty; Radiotherapy; Retrospective Studies; Sex Factors; Vincristine | 1995 |
Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; DNA Mutational Analysis; DNA, Neoplasm; Drug Resistance; Female; Gene Amplification; Gene Expression Regulation, Leukemic; Genes, p53; Humans; Infant; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Middle Aged; Neoplasm Proteins; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1995 |
Leukoencephalopathy detectable by magnetic resonance imaging: much ado about nothing? Regarding Matsumoto et al. IJROBP 32:913-918; 1995.
Topics: Brain; Child, Preschool; Drug Administration Schedule; Humans; Magnetic Resonance Imaging; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy | 1995 |
Leukoencephalopathy in childhood hematopoietic neoplasm caused by moderate-dose methotrexate and prophylactic cranial radiotherapy--an MR analysis.
Topics: Adolescent; Brain; Brain Damage, Chronic; Child; Child, Preschool; Cranial Irradiation; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis | 1995 |
Prognosis and treatment of seizures in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Daunorubicin; Epilepsy; Female; Humans; Incidence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Retrospective Studies; Seizures; Vincristine | 1995 |
Intracellular pharmacology and biochemistry of methotrexate and 6-mercaptopurine in childhood acute lymphoblastic leukemia.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Humans; Infusions, Intravenous; Leucovorin; Leukocytes, Mononuclear; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Pyrimidines | 1994 |
The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Cytarabine; Dexamethasone; Disease-Free Survival; Doxorubicin; Drug Administration Schedule; Humans; Infusions, Intravenous; Injections, Spinal; Life Tables; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Risk Factors; Survival Rate; Vincristine | 1995 |
MACOP-B +/- radiation therapy for diffuse large cell lymphoma. Analysis of the Stanford results according to prognostic indices.
Topics: Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Risk Factors; Survival Rate; Vincristine | 1993 |
Granulocyte colony-stimulating factor (G-CSF) as an adjunct to induction chemotherapy of adult acute lymphoblastic leukemia (ALL).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Cells; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fever; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Humans; Male; Methotrexate; Middle Aged; Neutropenia; Platelet Count; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tegafur; Time Factors | 1993 |
Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease.
Topics: Adult; Age Factors; Child; Drug Resistance; Humans; In Vitro Techniques; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1993 |
The frequency of micronuclei in bone-marrow erythroblasts during the treatment of childhood acute lymphoblastic leukaemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Daunorubicin; Erythroblasts; Female; Humans; Infant; Male; Methotrexate; Micronucleus Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Vincristine | 1993 |
Treatment of poor prognosis non-Hodgkin's lymphoma with intensive, inpatient combination chemotherapy of brief duration: long-term followup.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Prognosis; Survival Analysis; Vincristine | 1993 |
Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia.
Topics: Adolescent; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Marrow; Child; Child, Preschool; Cytarabine; Erythrocytes; Female; Humans; Lymphocytes; Male; Mercaptopurine; Methotrexate; Methyltransferases; Neoplasm Proteins; Neoplastic Stem Cells; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Teniposide; Treatment Failure | 1995 |
Selective treatment of SCID mice bearing methotrexate-transport-resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Drug Resistance; Humans; Leucovorin; Methotrexate; Mice; Mice, SCID; Neoplasm Transplantation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Heterologous; Trimetrexate | 1995 |
[Central nervous system relapses in acute lymphoblastic leukemia and different methods of prophylaxis].
Topics: Adolescent; Adult; Central Nervous System Neoplasms; Combined Modality Therapy; Cytarabine; Female; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Risk Factors; Survival Analysis | 1995 |
Changes in the oral health of children during treatment for acute lymphoblastic leukaemia.
Topics: Adolescent; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chlorhexidine; Daunorubicin; Dental Plaque Index; DMF Index; Female; Gingivitis; Humans; Infant; Longitudinal Studies; Male; Methotrexate; Oral Hygiene Index; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Statistics, Nonparametric; Vincristine | 1994 |
[Long-term follow up of therapy-conditioned cerebral changes in acute lymphatic leukemia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Combined Modality Therapy; Dementia; Follow-Up Studies; Humans; Infant; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quadriplegia; Radiotherapy Dosage; Remission Induction; Time Factors; Tomography, X-Ray Computed | 1995 |
Urinary N-acetyl-beta-D-glucosaminidase activity in leukaemic children during high-dose methotrexate therapy.
Topics: Acetylglucosaminidase; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Burkitt Lymphoma; Child; Creatinine; Diuresis; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Kidney Tubules, Proximal; Leucovorin; Leukemia; Lymphoma, Non-Hodgkin; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1995 |
Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Biological Transport; Child; Child, Preschool; Drug Resistance; Female; Humans; Infant; Leukemia, Erythroblastic, Acute; Leukocyte Count; Life Tables; Lymphocytes; Male; Methotrexate; Neoplasm Proteins; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Tetrahydrofolate Dehydrogenase; Time Factors; Tumor Cells, Cultured | 1995 |
Small noncleaved cell lymphoma and leukemia in adults. A retrospective study of 65 adults treated with the LMB pediatric protocols.
Topics: Adolescent; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Cyclophosphamide; Cytarabine; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome | 1995 |
Pharmacokinetics of HD-MTX in infants, children, and adolescents with non-B acute lymphoblastic leukemia.
Topics: Adolescent; Age Factors; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Retrospective Studies | 1995 |
An intensive re-treatment protocol for children with an isolated CNS relapse of acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Central Nervous System Neoplasms; Child; Child, Preschool; Clinical Protocols; Combined Modality Therapy; Critical Care; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Recurrence; Remission Induction; Time Factors | 1995 |
High-performance liquid chromatographic determination of methotrexate, 7-hydroxymethotrexate, 5-methyltetrahydrofolic acid and folinic acid in serum and cerebrospinal fluid.
Topics: Calibration; Child; Chromatography, High Pressure Liquid; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Specimen Handling; Tetrahydrofolates | 1994 |
Childhood acute lymphoblastic leukemia (ALL): sister chromatid exchange (SCE) frequency and lymphocyte subpopulations during therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chromosomes, Human; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Immunophenotyping; Infant; Lymphocyte Count; Lymphocyte Subsets; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Sister Chromatid Exchange; Time Factors; Vincristine | 1995 |
Impact of reinduction regimens for relapsed and refractory acute lymphoblastic leukemia in adults.
Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Aspartate-Ammonia Ligase; Clinical Trials as Topic; Cytarabine; Dose-Response Relationship, Drug; Humans; Idarubicin; Incidence; Methotrexate; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Salvage Therapy | 1994 |
Limitation of therapy in the treatment of childhood cancer: toxicity versus cure.
Topics: Child; Cranial Irradiation; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Assessment; Survival Rate | 1994 |
Association of 1800 cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukaemia. ISPACC. International Study Group on Psychosocial Aspects of Childhood Cancer.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Cranial Irradiation; Female; Humans; Injections, Spinal; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Retrospective Studies; Wechsler Scales | 1994 |
Educational attainment in long-term survivors of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Age of Onset; Cohort Studies; Combined Modality Therapy; Cranial Irradiation; Education, Special; Educational Status; Female; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Risk; Survivors | 1994 |
Second malignant tumors after elective end of therapy for a first cancer in childhood: a multicenter study in Italy.
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Central Nervous System Neoplasms; Child; Cranial Irradiation; Cross-Sectional Studies; Female; Follow-Up Studies; Hodgkin Disease; Humans; Incidence; Injections, Spinal; Italy; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Methotrexate; Neoplasms, Second Primary; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Registries; Risk Factors; Wilms Tumor | 1994 |
Bone marrow transplantation for primary refractory acute leukaemia.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Graft Rejection; Graft vs Host Disease; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Remission Induction; Survival Rate | 1994 |
Methotrexate and 6-mercaptopurine maintenance therapy for childhood acute lymphoblastic leukemia: dose adjustments by white cell counts or by pharmacokinetic parameters?
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Humans; Infant; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Platelet Count; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1994 |
Intensive intravenous methotrexate and mercaptopurine treatment of higher-risk non-T, non-B acute lymphocytic leukemia: A Pediatric Oncology Group study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Child; Child, Preschool; Female; Humans; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Analysis; Treatment Outcome | 1994 |
[The effect of polychemotherapy on hemopoiesis in acute lymphoblastic leukemia in children].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Female; Hematopoiesis; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Time Factors; Vincristine | 1993 |
A dental complication involving Pseudomonas during chemotherapy for acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cytarabine; Dental Care for Chronically Ill; Female; Humans; Immunocompromised Host; Methotrexate; Periapical Abscess; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Pseudomonas aeruginosa; Pseudomonas Infections; Remission Induction; Vincristine | 1994 |
Prognostic factors for long-term survival in leukemic marrow recipients with special emphasis on age and prophylaxis for graft-versus-host disease.
Topics: Adolescent; Adult; Age Factors; Aged; Bone Marrow Transplantation; Cause of Death; Child; Child, Preschool; Cyclosporine; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Infant; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Retrospective Studies; Risk Factors; Survival Rate | 1994 |
Successful bone marrow transplant for a patient with T-lymphoblastic lymphoma in second remission preconditioned by total-body irradiation plus melphalan and etoposide.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cyclosporine; Etoposide; Graft vs Host Disease; Humans; Male; Melphalan; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Whole-Body Irradiation | 1994 |
Poor outcome of intensive chemotherapy for adult acute lymphoblastic leukemia: a possible dose effect.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Leucovorin; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Recurrence; Remission Induction; Retrospective Studies; Survival Rate; Teniposide; Vincristine | 1994 |
Histologic changes in dental morphology induced by high dose chemotherapy and total body irradiation.
Topics: Abnormalities, Radiation-Induced; Amelogenesis; Antineoplastic Agents; Asparaginase; Bone Marrow Transplantation; Child, Preschool; Cyclophosphamide; Cytarabine; Dental Arch; Dental Enamel Hypoplasia; Dentinogenesis; Doxorubicin; Female; Humans; Immunosuppressive Agents; Maxillofacial Development; Mercaptopurine; Methotrexate; Odontogenesis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Tooth Eruption; Tooth Root; Vincristine; Whole-Body Irradiation | 1994 |
2,4-diamino-7-hydroxy-pteridines in biological fluids of patients on high-dose methotrexate.
Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pteridines | 1993 |
Changes in cell and protein content of cerebrospinal fluid in children with acute lymphoblastic leukaemia after allogeneic bone marrow transplantation.
Topics: Adolescent; Arachnoiditis; Bone Marrow Transplantation; Brain Injuries; Brain Neoplasms; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Transplantation, Homologous | 1993 |
[Treatment of acute lymphoblastic leukemia in adults by the modified protocol of L-10M (Sloan-Kettering): long-term outcome].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubicin; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Treatment Outcome | 1994 |
[Relapse of acute leukemia after allogeneic bone marrow transplantation].
Topics: Adolescent; Adult; Bone Marrow Transplantation; Female; Graft vs Host Disease; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Survival Rate | 1994 |
Successful treatment of acute lymphoblastic leukemia in a child with cystic fibrosis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Cystic Fibrosis; Cytarabine; Daunorubicin; Female; Humans; Mercaptopurine; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Teniposide; Vincristine | 1994 |
Myelopathy after intrathecal chemotherapy. A case report with unique magnetic resonance imaging changes.
Topics: Adolescent; Antineoplastic Agents; Contrast Media; Cytarabine; Drug Combinations; Female; Gadolinium DTPA; Humans; Injections, Spinal; Magnetic Resonance Imaging; Meglumine; Methotrexate; Organometallic Compounds; Paraplegia; Pentetic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Cord Diseases | 1994 |
Liver function studies in children with acute lymphocytic leukemia after cessation of therapy.
Topics: Adolescent; Adult; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bile Acids and Salts; Chemical and Drug Induced Liver Injury; Child; Daunorubicin; Follow-Up Studies; Humans; Liver; Mercaptopurine; Methotrexate; Nervous System Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine | 1994 |
Acute leukemia in association with Langerhans cell histiocytosis.
Topics: Adolescent; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Etoposide; Female; Histiocytosis, Langerhans-Cell; Humans; Infant; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Registries; Retrospective Studies; Surveys and Questionnaires; Vinblastine; Vincristine | 1994 |
High grade pyrexia following bone marrow transplantation as a neurotoxic complication of high-dose chemotherapy and radiotherapy in the UKALL XII Trial.
Topics: Adult; Bone Marrow Transplantation; Clinical Trials as Topic; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Fever; Humans; Male; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; United Kingdom; Whole-Body Irradiation | 1994 |
Toxicity following concurrent intrathecal and moderate-dose intravenous methotrexate.
Topics: Adolescent; Body Surface Area; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Injections, Spinal; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Trimethoprim, Sulfamethoxazole Drug Combination | 1993 |
Incidence of cataracts after single fraction total body irradiation: the role of steroids and graft versus host disease.
Topics: Adolescent; Adult; Bone Marrow Purging; Bone Marrow Transplantation; Cataract; Cataract Extraction; Child; Child, Preschool; Cohort Studies; Graft vs Host Disease; Humans; Incidence; Life Tables; Lymphocyte Depletion; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiation Injuries; Risk; Whole-Body Irradiation | 1993 |
Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Division; Drug Resistance; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1993 |
Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.
Topics: Bone Marrow; Child; Child, Preschool; Female; Guanine Nucleotides; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reference Values; Thionucleotides; Vincristine | 1993 |
Proteinuria due to suboptimal hydration with high-dose methotrexate therapy.
Topics: Adolescent; Bone Neoplasms; Burkitt Lymphoma; Child; Female; Fluid Therapy; Glomerular Filtration Rate; Glucose; Humans; Male; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteinuria; Sodium Bicarbonate | 1993 |
Intelligence function in children with acute lymphoblastic leukemia after treatment.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Injections, Spinal; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Wechsler Scales | 1993 |
Studies on the cross resistance of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Clone Cells; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Floxuridine; Folic Acid Antagonists; Humans; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1993 |
Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).
Topics: Binding Sites; Biological Transport; Carrier Proteins; Cell Line; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Tetrahydrofolates; Tumor Cells, Cultured | 1993 |
Determinants of the disparate antitumor effects of (6R)5,10-dideaza-5,6,7,8- tetrahydrofolate and methotrexate toward methotrexate resistant CCRF-CEM cells, characterized by severely impaired antifolate membrane transport.
Topics: Antineoplastic Agents; Carrier Proteins; Cell Line; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; Humans; Kinetics; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Tetrahydrofolates; Tumor Cells, Cultured | 1993 |
Risk taking and decision making of adolescent long-term survivors of cancer.
Topics: Adolescent; Adult; Alcohol Drinking; Attitude to Health; Combined Modality Therapy; Cranial Irradiation; Decision Making; Educational Status; Female; Humans; Injections, Spinal; Male; Marijuana Smoking; Methotrexate; Nursing Methodology Research; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prevalence; Psychology, Adolescent; Risk-Taking; Smoking; Surveys and Questionnaires; Time Factors | 1993 |
Long-term follow-up of treatment and potential cure of adult acute lymphocytic leukemia with MOAD: a non-anthracycline containing regimen.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Vincristine | 1993 |
Pharmacokinetics and in vitro studies of l-leucovorin. Comparison with the d and d,l-leucovorin.
Topics: Drug Synergism; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Pediococcus; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stereoisomerism; Tumor Cells, Cultured | 1993 |
Changes in the oral microflora during cytotoxic chemotherapy in children being treated for acute leukemia.
Topics: Adolescent; Analysis of Variance; Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Candida albicans; Candidiasis, Oral; Chi-Square Distribution; Child; Child, Preschool; Chlorhexidine; Colony Count, Microbial; Cytarabine; Daunorubicin; Etoposide; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Infant; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Mouth; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Streptococcus mutans; Thioguanine; Trimethoprim, Sulfamethoxazole Drug Combination; Vincristine | 1993 |
Late relapse after allogeneic bone marrow transplantation for Philadelphia-positive acute lymphoblastic leukaemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Combined Modality Therapy; Daunorubicin; Humans; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Recurrence; Remission Induction; Time Factors; Transplantation, Homologous; Vincristine | 1993 |
[Acute lymphoblastic leukemia in infants--results of treatment according to infant leukemia protocol--POG 8493].
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cortisone; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Drug Administration Schedule; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Rate; Vincristine | 1993 |
Long-term effects of treatment for acute lymphoblastic leukemia with and without cranial irradiation on growth and puberty: a comparative study.
Topics: Adolescent; Body Height; Brain; Child; Child, Preschool; Combined Modality Therapy; Female; Growth; Growth Disorders; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Puberty | 1993 |
A cancer patient with central venous catheter-related sepsis caused by Tsukamurella paurometabolum (Gordona aurantiaca)
Topics: Actinomycetales Infections; Aged; Catheterization, Central Venous; Female; Humans; Immunocompromised Host; Methotrexate; Microbial Sensitivity Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rhodococcus | 1993 |
Ten years' experience with LSA2-L2 therapy for childhood advanced lymphoblastic lymphoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 1993 |
Acute graft-versus-host disease prophylaxis with methotrexate and cyclosporine after busulfan and cyclophosphamide in patients with hematologic malignancies.
Topics: Adult; Busulfan; Chronic Disease; Combined Modality Therapy; Cyclophosphamide; Cyclosporine; Female; Follow-Up Studies; Graft vs Host Disease; Humans; Incidence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1993 |
Methotrexate, cyclosporine, or both to prevent graft-versus-host disease after HLA-identical sibling bone marrow transplants for early leukemia?
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Female; Graft vs Host Disease; Histocompatibility; Humans; Infant; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1993 |
Cranial computed tomography in children with acute lymphoblastic leukemia after prophylactic treatment with cranial radiation therapy and intrathecal methotrexate.
Topics: Brain; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Infant; Injections, Spinal; Intelligence; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Tomography, X-Ray Computed | 1993 |
Severe interaction between methotrexate and a macrolide-like antibiotic.
Topics: Adolescent; Anti-Bacterial Agents; Drug Interactions; Humans; Macrolides; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Virginiamycin | 1993 |
Intensive alternating drug pairs for treatment of high-risk childhood acute lymphoblastic leukemia. A Pediatric Oncology Group pilot study.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cytarabine; Daunorubicin; Drug Administration Schedule; Female; Humans; Hydrocortisone; Infant; Injections, Intramuscular; Injections, Intravenous; Injections, Spinal; Leukemia-Lymphoma, Adult T-Cell; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide; Treatment Failure | 1993 |
Increased risk of neurological relapse in acute lymphoblastic leukemias with high levels of cerebrospinal fluid thymidine kinase at diagnosis.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Humans; Injections, Spinal; Leukemic Infiltration; Leukocyte Count; Male; Meninges; Methotrexate; Middle Aged; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prognosis; Remission Induction; Risk Factors; Thymidine Kinase; Time Factors | 1993 |
[Treatment of adult acute lymphoblastic leukemia with DCVP-l-asp protocol].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Survival Rate; Vincristine | 1993 |
Effect of chemotherapy on the energy and protein metabolism of children near the end of treatment for acute lymphoblastic leukemia.
Topics: Adolescent; Child; Energy Metabolism; Female; Humans; Male; Mercaptopurine; Methotrexate; Models, Theoretical; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteins; Remission Induction | 1993 |
Central nervous system treatment in childhood acute lymphoblastic leukemia. Long-term follow-up of patients diagnosed between 1973 and 1985.
Topics: Brain Neoplasms; Child; Child, Preschool; Cranial Irradiation; Humans; Infant; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Survival Rate | 1993 |
Child cerebrospinal fluid analysis by capillary electrophoresis and laser-induced fluorescence detection.
Topics: Adolescent; Amines; Amino Acids; Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Electrophoresis, Capillary; Female; Humans; Lasers; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spectrometry, Fluorescence | 1995 |
Cured of acute lymphoblastic leukaemia but lost for words.
Topics: Adolescent; Anomia; Antimetabolites, Antineoplastic; Cranial Irradiation; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Status Epilepticus | 1995 |
Evaluation of clinical assays for measuring high-dose methotrexate in plasma.
Topics: Child; Child, Preschool; Chromatography, High Pressure Liquid; Cross Reactions; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Fluorescence Polarization Immunoassay; Humans; Immunoenzyme Techniques; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results | 1996 |
Successful treatment of intrathecal methotrexate overdose by using ventriculolumbar perfusion and intrathecal instillation of carboxypeptidase G2.
Topics: Antimetabolites, Antineoplastic; Child; Drug Overdose; gamma-Glutamyl Hydrolase; Humans; Injections, Spinal; Lumbosacral Region; Male; Methotrexate; Perfusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Plasma free iron and chemotherapy toxicity.
Topics: Antineoplastic Agents; Doxorubicin; Free Radicals; Humans; Iron; Iron Chelating Agents; Methotrexate; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transferrin | 1996 |
Clinical and experimental pharmacokinetic interaction between 6-mercaptopurine and methotrexate.
Topics: Adolescent; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Biotransformation; Child; Child, Preschool; Drug Interactions; Female; HL-60 Cells; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Rats, Wistar; Time Factors | 1996 |
High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia. Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Female; Humans; Infant; Leukocyte Count; Male; Methotrexate; Netherlands; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Treatment Outcome | 1996 |
Mutations in the gene for human dihydrofolate reductase: an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate.
Topics: Adolescent; Animals; Antimetabolites, Antineoplastic; Base Sequence; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Genes; Genetic Vectors; Humans; Infant; Male; Methotrexate; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retroviridae; Tetrahydrofolate Dehydrogenase | 1996 |
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Homocysteine; Humans; Mercaptopurine; Methionine; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
True histiocytic lymphoma following therapy for lymphoblastic neoplasms.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Neoplasms; Child; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Etoposide; Fatal Outcome; Humans; Ifosfamide; Lymphoma, Large B-Cell, Diffuse; Male; Mediastinal Neoplasms; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasms, Second Primary; Neoplastic Stem Cells; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Remission Induction; Scapula; Spinal Neoplasms; Vincristine | 1996 |
Intrathecal leucovorin after intrathecal methotrexate overdose.
Topics: Catheterization, Central Venous; Child; Cytarabine; Drug Overdose; Humans; Hydrocortisone; Injections, Spinal; Leucovorin; Male; Medication Errors; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Childhood acute lymphoblastic leukemia relapse in the uterine cervix.
Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Neoplasms; Child; Cyclophosphamide; Daunorubicin; Female; Follow-Up Studies; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Ultrasonography; Uterine Cervical Neoplasms; Vaginal Smears; Vincristine | 1996 |
[Separation of methotrexate-polyglutamates by capillary electrophoresis and its application to the measurement of gamma-glutamyl hydrolase activity in human leukemia cells in culture].
Topics: Down-Regulation; Electrophoresis, Capillary; gamma-Glutamyl Hydrolase; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Tumor Cells, Cultured | 1996 |
Induction toxicity of a modified Memorial Sloan-Kettering-New York II Protocol in children with relapsed acute lymphoblastic leukemia: a single institution study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Daunorubicin; Female; Humans; Male; Methotrexate; Neutropenia; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Remission Induction; Vincristine | 1996 |
Effectiveness of intensified rotational combination chemotherapy for late hematologic relapse of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Disease-Free Survival; Drug Administration Schedule; Female; Growth Disorders; Humans; Hydrocortisone; Leukemic Infiltration; Life Tables; Male; Meninges; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Prospective Studies; Remission Induction; Salvage Therapy; Survival Analysis; Survival Rate; Teniposide; Testis; Time Factors; Treatment Outcome; Vincristine | 1996 |
Magnetic resonance imaging and neurological evaluation after treatment with high-dose methotrexate for acute lymphocytic leukaemia in young children.
Topics: Age Factors; Antimetabolites, Antineoplastic; Brain Diseases; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Neurologic Examination; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 1996 |
[Radiological case of the month. Leukoencephalopathy caused by methotrexate in a child treated for acute lymphoblastic leukemia].
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Demyelinating Diseases; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed | 1996 |
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD).
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Female; Humans; Male; Methotrexate; Middle Aged; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 1996 |
Acute tumor lysis syndrome following intrathecal methotrexate.
Topics: Adolescent; Antimetabolites, Antineoplastic; Humans; Injections, Spinal; Male; Meninges; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Lysis Syndrome | 1996 |
Melphalan-total body irradiation and autologous bone marrow transplantation for adult acute leukemia beyond first remission.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Bone Marrow Transplantation; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Leukemia; Leukemia, Myeloid; Male; Melphalan; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Salvage Therapy; Survival Analysis; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; Whole-Body Irradiation | 1996 |
P300 abnormalities in long-time survivors of acute lymphoblastic leukemia in childhood--side effects of CNS prophylaxis?
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Brain; Brain Mapping; Cerebral Cortex; Child; Combined Modality Therapy; Cranial Irradiation; Event-Related Potentials, P300; Female; Follow-Up Studies; Humans; Leukemic Infiltration; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage | 1996 |
Lenńox-Gastaut syndrome associated with leukoencephalopathy.
Topics: Adolescent; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Damage, Chronic; Calcinosis; Cranial Irradiation; Cytarabine; Dementia; Doxorubicin; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Humans; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Movement Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiation Injuries; Syndrome; Vincristine | 1996 |
Intensive oral methotrexate protects against lymphoid marrow relapse in childhood B-precursor acute lymphoblastic leukemia.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 1996 |
Acute lymphoblastic leukemia in Ehlers-Danlos syndrome.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Cytarabine; Disease-Free Survival; Doxorubicin; Ehlers-Danlos Syndrome; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine | 1996 |
[Toxicity of high dose methotrexate repeated infusions in children treated for acute lymphoblastic leukemia and osteosarcoma].
Topics: Antineoplastic Agents; Bone Neoplasms; Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Kidney; Liver; Methotrexate; Neutropenia; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytopenia | 1996 |
[Obesity as the first manifestation of central nervous system involvement in acute lymphoblastic leukemia].
Topics: Antineoplastic Agents; Body Mass Index; Child; Combined Modality Therapy; Cytarabine; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Methotrexate; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Dosage; Recurrence | 1996 |
Chemotherapy for acute lymphoblastic leukemia may cause subtle changes of the spinal cord detectable by somatosensory evoked potentials.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Evoked Potentials, Somatosensory; Female; Humans; Infant; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Neural Conduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reaction Time; Remission Induction; Spinal Cord | 1997 |
Quantitative EEG in long-term survivors of acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Cerebral Cortex; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Drug; Electroencephalography; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Signal Processing, Computer-Assisted | 1996 |
Methotrexate plasma pharmacokinetics: importance of assay method.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Brain perfusion after treatment of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Brain; Child; Child, Preschool; Cranial Irradiation; Cysteine; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Neurologic Examination; Organotechnetium Compounds; Oximes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 1997 |
Testicular morphological changes in children with acute lymphoblastic leukemia following chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Child; Child, Preschool; Cyclophosphamide; Doxorubicin; Etoposide; Humans; Hydrocortisone; Leydig Cells; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Sertoli Cells; Spermatogonia; Testis | 1996 |
Time course of methotrexate polyglutamate formation and degradation in the pre-B-leukaemia cell line Nalm6 and in lymphoblasts from children with leukaemia.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Resistance, Neoplasm; Humans; Kinetics; Lymphocytes; Male; Methotrexate; Polyglutamic Acid; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1996 |
Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression.
Topics: Adolescent; Adult; Aged; Biological Transport; Blast Crisis; Carrier Proteins; Child; Child, Preschool; Drug Resistance; Fluoresceins; Folic Acid; Humans; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein | 1997 |
Toxicity of CNS prophylaxis for childhood leukemia.
Topics: Antimetabolites, Antineoplastic; Central Nervous System Diseases; Child; Cognition; Cranial Irradiation; Female; Growth; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1997 |
Development of the anterior cingulate syndrome in a child due to delayed necrotising methotrexate leukoencephalopathy.
Topics: Akinetic Mutism; Brain Diseases; Child; Cranial Irradiation; Demyelinating Diseases; Fatal Outcome; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed | 1997 |
In vitro drug sensitivity testing can predict induction failure and early relapse of childhood acute lymphoblastic leukemia.
Topics: Aclarubicin; Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bleomycin; Bone Marrow; Cell Survival; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Etoposide; Follow-Up Studies; Humans; Infant; Infant, Newborn; Life Tables; Melphalan; Methotrexate; Mitomycin; Mitoxantrone; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Recurrence; Remission Induction; Tumor Cells, Cultured; Vincristine | 1997 |
Final height and puberty in 40 patients after antileukaemic treatment during childhood.
Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Combined Modality Therapy; Cranial Irradiation; Dose-Response Relationship, Radiation; Female; Growth; Growth Disorders; Humans; Longitudinal Studies; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Puberty | 1997 |
Systemic effect of intrathecal methotrexate during the initial phase of treatment of childhood acute lymphoblastic leukemia. The European Organization for Research and Treatment of Cancer Children's Leukemia Cooperative Group.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Blast Crisis; Cell Count; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Retrospective Studies | 1997 |
Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
Topics: Adolescent; Adult; Antidotes; Antimetabolites, Antineoplastic; Carboxypeptidases; Child; Child, Preschool; Female; Humans; Infant; Kidney; Kidney Diseases; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Thymidine | 1997 |
Treatment of isolated testicular recurrence of acute lymphoblastic leukemia without radiotherapy. Report from the Dutch Late Effects Study Group.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Child; Child, Preschool; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Testicular Neoplasms | 1997 |
Serum aminotransferase elevation during and following treatment of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Liver Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transaminases; Treatment Outcome | 1997 |
Nutritional state alterations in children with acute lymphoblastic leukemia during induction and consolidation of chemotherapy.
Topics: Adolescent; Anthropometry; Antineoplastic Combined Chemotherapy Protocols; Arm; Asparaginase; Body Constitution; Child; Child, Preschool; Cohort Studies; Cytarabine; Drug Administration Schedule; Energy Metabolism; Epirubicin; Female; Gastrointestinal Diseases; Hospitals, General; Hospitals, Pediatric; Humans; Infant; Male; Mercaptopurine; Methotrexate; Nutrition Disorders; Nutritional Status; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk; Skinfold Thickness; Vincristine | 1997 |
On the prognostic value of systemic methotrexate clearance in childhood acute lymphocytic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Female; Follow-Up Studies; Humans; Infant; Male; Metabolic Clearance Rate; Methotrexate; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Probability; Prognosis; Recurrence; Reproducibility of Results; Risk Assessment | 1997 |
[Psychological functions in children treated for acute lymphatic leukemia. A 5-year follow-up of three different age groups of children].
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child Behavior; Cognition; Female; Follow-Up Studies; Humans; Intelligence Tests; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychological Tests; Social Adjustment | 1997 |
Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells.
Topics: Acute Disease; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid Antagonists; HL-60 Cells; Humans; Indoles; Isoindoles; Kinetics; Leukemia, Myeloid; Methotrexate; Neoplasm Proteins; Organ Specificity; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1997 |
Role of cranial radiotherapy for childhood T-cell acute lymphoblastic leukemia with high WBC count and good response to prednisone. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster groups.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cranial Irradiation; Daunorubicin; Female; Humans; Infant; Injections, Spinal; Leukemia-Lymphoma, Adult T-Cell; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Survival Rate; Vincristine | 1997 |
Neurophysiological findings in long-term survivors of acute lymphoblastic leukaemia in childhood treated with the BFM protocol 81 SR-A/B.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cerebral Cortex; Child; Child, Preschool; Daunorubicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Evoked Potentials, Visual; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Reaction Time; Vincristine | 1997 |
[Inefficacy of exchange-transfusion in case of a methotrexate poisoning].
Topics: Acute Kidney Injury; Adult; Antidotes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Diuretics; Drug Overdose; Exchange Transfusion, Whole Blood; Furosemide; Humans; Leucovorin; Male; Methotrexate; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Failure | 1997 |
Salvage therapy for relapsed or refractory childhood acute lymphocytic leukemia by alternative administration a lymphoid- and myeloid-directed chemotherapeutic regimen consisting of dual modulation of ara-C, hydroxyurea, and etoposide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Dexamethasone; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Fever; Gastrointestinal Diseases; Humans; Hydrocortisone; Hydroxyurea; Leucovorin; Male; Methotrexate; Mitoxantrone; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Salvage Therapy; Treatment Outcome | 1997 |
Assessment of brain perfusion by 99mTc-HMPAO SPECT in akinetic mutism due to high-dose intravenous methotrexate therapy.
Topics: Akinetic Mutism; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Dominance, Cerebral; Dose-Response Relationship, Drug; Female; Frontal Lobe; Humans; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regional Blood Flow; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 1997 |
Nerve lesions after therapy for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Axons; Brachial Plexus; Case-Control Studies; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Demyelinating Diseases; Evoked Potentials, Somatosensory; Female; Humans; Male; Median Nerve; Methotrexate; Motor Skills; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Disorders; Reflex, Stretch; Risk Factors; Spinal Cord; Spinal Cord Diseases; Tibial Nerve; Vincristine | 1998 |
Methotrexate, homocysteine, and seizures.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cysteine; Epilepsy, Tonic-Clonic; Homocysteine; Humans; Infant; Male; Methotrexate; Neurotransmitter Agents; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1998 |
Pure methotrexate encephalopathy presenting with seizures: CT and MRI features.
Topics: Antineoplastic Agents; Brain; Brain Diseases; Calcinosis; Child, Preschool; Female; Humans; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Seizures; Tomography, X-Ray Computed | 1998 |
Variable expression of RFC1 in human leukemia cell lines resistant to antifolates.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Phenotype; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Tetrahydrofolate Dehydrogenase; Thiophenes; Tumor Cells, Cultured | 1998 |
Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Follow-Up Studies; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1998 |
Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromosomes, Human, Pair 12; DNA-Binding Proteins; ETS Translocation Variant 6 Protein; Female; Humans; Infant; Male; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-ets; Repressor Proteins; Transcription Factors; Translocation, Genetic | 1998 |
Assessment of the emetogenic potential of intrathecal chemotherapy and response to prophylactic treatment with ondansetron.
Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Female; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Nausea; Ondansetron; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 1998 |
[Retrospective analysis of elderly patients > or = 60 years of age with acute leukemia].
Topics: Aclarubicin; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Daunorubicin; DNA; Female; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Retrospective Studies; Vincristine | 1998 |
Acute lymphoblastic leukemia: dental health of children in maintenance therapy.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Case-Control Studies; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Dental Care for Chronically Ill; Dental Caries; DMF Index; Female; Humans; Male; Mercaptopurine; Methotrexate; Oral Hygiene; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine | 1998 |
Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Child; Child, Preschool; Cytarabine; Humans; Hydrocortisone; Injections, Spinal; Leukemic Infiltration; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence | 1998 |
Clinical and pharmacokinetic risk factors for high-dose methotrexate-induced toxicity in children with acute lymphoblastic leukemia--a logistic regression analysis.
Topics: Bone Marrow; Child; Child, Preschool; Female; Humans; Liver; Male; Methotrexate; Mouth; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 1998 |
Cerebrospinal fluid concentrations of nitrate plus nitrite during the treatment of acute lymphoblastic leukaemia in childhood.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Infant; Methotrexate; Nitrates; Nitrites; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1998 |
[Peripheral blood stem cell transplantation in adult acute lymphoblastic leukemia as postremission therapy].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Hematopoietic Stem Cell Transplantation; Humans; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Transplantation Conditioning; Vincristine | 1998 |
Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy.
Topics: Adolescent; Amino Acid Sequence; Antimetabolites, Antineoplastic; Carrier Proteins; Child; Child, Preschool; Female; Gene Expression; Humans; Immunophenotyping; Infant; K562 Cells; Leukemia, T-Cell; Male; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Molecular Sequence Data; Ploidies; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; Tritium; Tumor Cells, Cultured | 1998 |
Reduced energy expenditure in preobese children treated for acute lymphoblastic leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Body Mass Index; Child; Energy Metabolism; Female; Humans; Male; Mercaptopurine; Methotrexate; Obesity; Physical Exertion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Reference Values; Survivors; Vincristine; Weight Gain | 1998 |
Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
Topics: Antimetabolites, Antineoplastic; Child; Drug Resistance, Neoplasm; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase; Tumor Cells, Cultured | 1998 |
Pharmacokinetics and pharmacodynamics of oral methotrexate and mercaptopurine in children with lower risk acute lymphoblastic leukemia: a joint children's cancer group and pediatric oncology branch study.
Topics: Administration, Oral; Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Asparaginase; Biological Availability; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; DNA Adducts; Erythrocytes; Female; Guanosine Triphosphate; Humans; Infant; Injections, Spinal; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Recurrence; Thionucleotides; Treatment Outcome; Vincristine | 1998 |
A case for the use of aminopterin in treatment of patients with leukemia based on metabolic studies of blasts in vitro.
Topics: Aminopterin; Cells, Cultured; Child; Folic Acid Antagonists; Humans; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1996 |
Therapeutic innovation: the up-front window.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Child; Clinical Trials as Topic; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Topotecan | 1998 |
Evidence for cerebellar-frontal subsystem changes in children treated with intrathecal chemotherapy for leukemia: enhanced data analysis using an effect size model.
Topics: Adolescent; Anthropometry; Antimetabolites, Antineoplastic; Cerebellum; Child; Cognition; Female; Follow-Up Studies; Frontal Lobe; Humans; Injections, Spinal; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1998 |
Childhood acute lymphoblastic leukaemia: outcomes of 54 consecutive patients treated in Auckland 1985-1991.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Humans; Infant; Mercaptopurine; Methotrexate; New Zealand; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Proportional Hazards Models; Prospective Studies; Radiotherapy, Adjuvant; Survival Analysis; Treatment Outcome; Vincristine | 1998 |
Allogeneic and autologous bone marrow transplantation in single centre experience.
Topics: Adult; Bone Marrow Transplantation; Cyclosporine; Graft vs Host Disease; Hodgkin Disease; Humans; Immunosuppressive Agents; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Registries; Transplantation, Autologous; Transplantation, Homologous | 1998 |
Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Coloring Agents; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; HL-60 Cells; Humans; Infant; Infant, Newborn; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Neoplasm Proteins; Neoplastic Stem Cells; Polyglutamic Acid; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sensitivity and Specificity; Staining and Labeling; Tetrazolium Salts; Thiazoles; Thymidylate Synthase; U937 Cells | 1999 |
Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity.
Topics: Amino Acids; Animals; Asparagine; Cell Count; Dose-Response Relationship, Drug; Fluorouracil; Glutamine; Humans; Leukemia; Leukemia P388; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1998 |
Outcomes and prognostic factors of Chinese children with acute lymphoblastic leukemia in Hong Kong: preliminary results.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asian People; Asparaginase; Child; Child, Preschool; Daunorubicin; Female; Follow-Up Studies; Hong Kong; Humans; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Survival Rate; Treatment Outcome; Vincristine | 1999 |
Intraventricular concentration times time (C x T) methotrexate and cytarabine for patients with recurrent meningeal leukemia and lymphoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cytarabine; Female; Humans; Injections, Intraventricular; Male; Meningeal Neoplasms; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Treatment Outcome | 1999 |
[Adults treated as children for acute lymphocytic leukemia--methotrexate, late effects and quality of life].
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Female; Follow-Up Studies; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quality of Life; Regional Medical Programs; Socioeconomic Factors; Surveys and Questionnaires; Survivors; Treatment Outcome | 1999 |
Allogeneic bone marrow transplantation in second remission of childhood acute lymphoblastic leukemia: a population-based case control study from the Nordic countries.
Topics: Adolescent; Bone Marrow Transplantation; Case-Control Studies; Child; Child, Preschool; Cyclosporine; Female; Finland; Graft vs Host Disease; Humans; Iceland; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Scandinavian and Nordic Countries; Time Factors; Treatment Outcome | 1999 |
Neurodevelopmental outcome of infants with acute lymphoblastic leukemia: a Children's Cancer Group report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Damage, Chronic; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Daunorubicin; Developmental Disabilities; Female; Follow-Up Studies; Humans; Infant; Injections, Spinal; Leucovorin; Leukemic Infiltration; Male; Mercaptopurine; Methotrexate; Movement Disorders; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Psychomotor Performance; Remission Induction; Risk; Socioeconomic Factors; Survivors; Vincristine | 1999 |
Successful treatment of monoclonal, aggressive Epstein-Barr virus-associated B-cell lymphoproliferative disorder in a child with acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Child; Herpesvirus 4, Human; Humans; Immunosuppressive Agents; Lung Neoplasms; Lymphoma, B-Cell; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 1999 |
10-Formyl-dihydrofolic acid is bioactive in human leukemia cells.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Hematinics; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1999 |
Glioblastoma multiforme following prophylactic cranial irradiation and intrathecal methotrexate in a child with acute lymphoblastic leukaemia : a case report.
Topics: Antimetabolites, Antineoplastic; Child; Glioblastoma; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy | 1999 |
Rapid infusion of high-dose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphomas.
Topics: Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Brain Neoplasms; Chi-Square Distribution; Cranial Irradiation; Disease-Free Survival; Dose Fractionation, Radiation; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Karnofsky Performance Status; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, Adjuvant; Remission Induction; Survival Rate; Treatment Outcome | 1999 |
Toxic epidermal necrolysis and graft vs. host disease: a clinical spectrum but a diagnostic dilemma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Diagnosis, Differential; Diarrhea; Fatal Outcome; Fever; Graft vs Host Disease; Humans; Liver Failure; Lymphoma, B-Cell; Male; Methotrexate; Middle Aged; Platelet Transfusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency; Stevens-Johnson Syndrome | 1999 |
Intrathecal methotrexate-induced megaloblastic anemia in patients with acute leukemia.
Topics: Adult; Anemia, Megaloblastic; Antimetabolites, Antineoplastic; Female; Folic Acid; Humans; Injections, Spinal; Leukemia, Myelomonocytic, Acute; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 1999 |
Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.
Topics: Antimetabolites, Antineoplastic; Cerebrospinal Fluid; Child, Preschool; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Paresis; Peripheral Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spinal Nerve Roots | 1999 |
Wilms' tumour gene (wt1) expression at diagnosis has no prognostic relevance in childhood acute lymphoblastic leukaemia treated by an intensive chemotherapy protocol.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; DNA-Binding Proteins; Female; Gene Expression Regulation, Leukemic; Genes, Wilms Tumor; Humans; Life Tables; Male; Mercaptopurine; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Transcription Factors; Vincristine; WT1 Proteins | 1999 |
Children with acute lymphoblastic leukemia who receive T-cell-depleted HLA mismatched marrow allografts from unrelated donors have an increased incidence of primary graft failure but a similar overall transplant outcome.
Topics: Adolescent; Antibodies, Monoclonal; Bone Marrow Transplantation; Child; Child, Preschool; Cyclosporine; Disease-Free Survival; Female; Histocompatibility Testing; HLA-C Antigens; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Infant; Living Donors; Lymphocyte Depletion; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sex Factors; Survival Analysis; T-Lymphocytes; Time Factors; Transplantation, Homologous; Treatment Failure; Treatment Outcome | 1999 |
Defining the optimal dosage of methotrexate for childhood acute lymphoblastic leukemia. New insights from the lab and clinic.
Topics: Antimetabolites, Antineoplastic; Child; Dose-Response Relationship, Drug; Humans; Methotrexate; Ploidies; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
Lack of cross-resistance between prednisolone and methotrexate in childhood acute lymphoblastic leukemia? A preliminary analysis.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Child; Cryopreservation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Tumor Cells, Cultured | 1999 |
Prediction of methotrexate elimination after high dose infusion in children with acute lymphoblastic leukaemia using a population pharmacokinetic approach.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bayes Theorem; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Retrospective Studies; Time Factors | 1999 |
Retinoblastoma with acute lymphoblastic leukemia, polyposis coli, and multiple hamartomas.
Topics: Adenomatous Polyposis Coli; Antimetabolites, Antineoplastic; Barium Sulfate; Child, Preschool; Enema; Glucocorticoids; Hamartoma Syndrome, Multiple; Humans; Male; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography; Retinal Neoplasms; Retinoblastoma | 1998 |
Venipuncture versus central venous access: a comparison of methotrexate levels in pediatric leukemia patients.
Topics: Adolescent; Antimetabolites, Antineoplastic; Catheterization, Central Venous; Child; Child, Preschool; Evaluation Studies as Topic; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Phlebotomy; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
[Acute leukemia in Jehovah's Witnesses].
Topics: Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blood Transfusion; Christianity; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Fatal Outcome; Female; Humans; Male; Mercaptopurine; Methotrexate; Personnel, Hospital; Physician-Patient Relations; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Refusal to Treat; Remission Induction; Right to Die; Treatment Refusal; Vincristine | 1999 |
Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Child; Guanine; Humans; Inosine; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
A magnetic resonance abnormality correlating with permeability of the blood-brain barrier in a child with chemical meningitis during central nervous system prophylaxis for acute leukemia.
Topics: Albumins; alpha-Macroglobulins; Antimetabolites, Antineoplastic; Blood-Brain Barrier; Cell Membrane Permeability; Child, Preschool; Humans; Immunoglobulin G; Injections, Spinal; Magnetic Resonance Imaging; Male; Meningitis; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
Rapid molecular response during early induction chemotherapy predicts a good outcome in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Gene Rearrangement; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Neoplastic Stem Cells; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk; Time Factors; Treatment Outcome; Vincristine | 2000 |
Cerebral glucose metabolism in survivors of childhood acute lymphoblastic leukemia.
Topics: Adolescent; Age Factors; Antimetabolites, Antineoplastic; Attention; Brain; Brain Diseases; Brain Neoplasms; Child; Cranial Irradiation; Female; Fluorodeoxyglucose F18; Glucose; Humans; Leukocyte Count; Male; Mental Processes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Radiation Injuries; Radiopharmaceuticals; Radiotherapy Dosage; Survivors; Tomography, Emission-Computed | 2000 |
Individualized methotrexate dosing in children with relapsed acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2000 |
[The efficacy of BFM-90 program in the treatment of acute lymphoblastic leukemia in children in the studies of Polish pediatric leukemia/lymphoma group].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Treatment Outcome; Vincristine | 1998 |
[The analysis of failures in the treatment of children with non-B non-Hodgkin's lymphoma. Polish pediatric leukemia/lymphoma study group report].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Follow-Up Studies; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Neoplasm Staging; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Survival Rate; Treatment Failure; Vincristine | 1998 |
Variability in methotrexate serum and cerebrospinal fluid pharmacokinetics in children with acute lymphocytic leukemia: relation to assay methodology and physiological variables.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychological Techniques | 2000 |
Cutaneous side effects of medium dose methotrexate in children with acute lymphoblastic leukaemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Drug Eruptions; Eosinophilia; Erythema; Exanthema; Female; Humans; Leg Dermatoses; Male; Methotrexate; Pigmentation Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2000 |
Intracranial meningioma following childhood irradiation for leukaemia.
Topics: Adult; Antimetabolites, Antineoplastic; Child, Preschool; Cranial Irradiation; Female; Humans; Meningeal Neoplasms; Meningioma; Methotrexate; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed | 2000 |
Academic career after treatment for acute lymphoblastic leukaemia.
Topics: Adolescent; Adult; Age of Onset; Antimetabolites, Antineoplastic; Child; Child, Preschool; Cranial Irradiation; Education, Special; Educational Status; Female; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Regression Analysis; Retrospective Studies; Risk Factors; Sex Factors; Survivors | 2000 |
Intellectual, neuropsychological, and academic functioning in long-term survivors of leukemia.
Topics: Achievement; Adolescent; Antineoplastic Agents; Asthma; Brain; Child; Chronic Disease; Cognition Disorders; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Injections, Spinal; Intelligence; Intelligence Tests; Long-Term Care; Male; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Severity of Illness Index; Survivors | 2000 |
Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia.
Topics: B-Lymphocytes; Biological Transport; Cell Membrane; Drug Resistance, Neoplasm; gamma-Glutamyl Hydrolase; Humans; Methotrexate; Neoplastic Stem Cells; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Thymidylate Synthase; Tumor Cells, Cultured | 2000 |
Comparative analysis of methotrexate polyglutamates in lymphoblast preparations from bone marrow and blood, and the contribution of residual red blood cells.
Topics: Adolescent; Antimetabolites, Antineoplastic; Bone Marrow; Child; Child, Preschool; Erythrocytes; Female; Humans; Leukemia, Myeloid, Acute; Lymphocytes; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 2000 |
Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole.
Topics: Adolescent; Anti-Infective Agents; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Fatal Outcome; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Stevens-Johnson Syndrome; Trimethoprim, Sulfamethoxazole Drug Combination | 2000 |
[Carboxypeptidase-G2-rescue in a woman with methotrexate-induced renal failure].
Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Creatinine; Female; gamma-Glutamyl Hydrolase; Humans; Infusions, Intravenous; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 2000 |
Methotrexate treatment protocols and the central nervous system: significant cure with significant neurotoxicity.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Central Nervous System; Central Nervous System Diseases; Child; Child, Preschool; Electroencephalography; Female; Humans; Leucovorin; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, Emission-Computed, Single-Photon | 2000 |
Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Daunorubicin; Etoposide; Female; Flow Cytometry; Humans; Hydrocortisone; Immunophenotyping; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm, Residual; Neoplastic Cells, Circulating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Prospective Studies; Remission Induction; Treatment Outcome; Vincristine | 2000 |
White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings.
Topics: Adolescent; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Brain Injuries; Child; Child, Preschool; Cytarabine; Demyelinating Diseases; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiotherapy, Adjuvant; Statistics, Nonparametric | 2000 |
High-dose methotrexate is lethal to rats. Why give it to children?
Topics: Animals; Antimetabolites, Antineoplastic; Child; Humans; Methotrexate; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats | 2000 |
Fasting hypoglycemia is common during maintenance therapy for childhood acute lymphoblastic leukemia.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Child; Child, Preschool; Fasting; Female; Finland; Humans; Hypoglycemia; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Statistics, Nonparametric | 2001 |
Motor nervous pathway function is impaired after treatment of childhood acute lymphoblastic leukemia: a study with motor evoked potentials.
Topics: Adolescent; Antineoplastic Agents; Case-Control Studies; Child; Child, Preschool; Evoked Potentials, Motor; Female; Humans; Male; Methotrexate; Motor Neuron Disease; Neurologic Examination; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2001 |
Hepatic dysfunction in children with acute lymphoblastic leukemia in remission: relation to hepatitis infection.
Topics: Antimetabolites, Antineoplastic; Case-Control Studies; Chemical and Drug Induced Liver Injury; Child; Egypt; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Incidence; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Saudi Arabia | 2001 |
Reversal of neurologic disturbances related to high-dose methotrexate by aminophylline.
Topics: Aminophylline; Antimetabolites, Antineoplastic; Child; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Renal Insufficiency | 2001 |
Preliminary experience with a new chemotherapy regimen for adults with acute lymphoblastic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Cyclophosphamide; Cytogenetic Analysis; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2001 |
The history of folic acid.
Topics: Anemia; Brain Diseases; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; History, 20th Century; Humans; Hyperhomocysteinemia; Methotrexate; Neural Tube Defects; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications, Hematologic; Vascular Diseases; Vitamin B 12 Deficiency | 2001 |
Early onset Pneumocystis carinii pneumonia after allogeneic peripheral blood stem cell transplantation.
Topics: Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modality Therapy; Cytarabine; Daunorubicin; Etoposide; Fatal Outcome; Hematopoietic Stem Cell Transplantation; Humans; Immune System; Immunocompromised Host; Male; Methotrexate; Middle Aged; Opportunistic Infections; Pneumonia, Pneumocystis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Respiratory Insufficiency; Transplantation Conditioning; Transplantation, Autologous; Trimethoprim, Sulfamethoxazole Drug Combination; Vincristine; Whole-Body Irradiation | 2001 |
Long-term cerebral metabolite changes on proton magnetic resonance spectroscopy in patients cured of acute lymphoblastic leukemia with previous intrathecal methotrexate and cranial irradiation prophylaxis.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Aspartic Acid; Brain; Brain Infarction; Cerebrovascular Disorders; Child; Choline; Cranial Irradiation; Creatine; Female; Humans; Injections, Spinal; Magnetic Resonance Spectroscopy; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Time Factors | 2001 |
Magnetic resonance imaging detection of avascular necrosis of the bone in children receiving intensive prednisone therapy for acute lymphoblastic leukemia or non-Hodgkin lymphoma.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Arthralgia; Arthroplasty, Replacement, Hip; Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Female; Femur Head Necrosis; Humans; Lymphoma, Non-Hodgkin; Magnetic Resonance Imaging; Male; Mercaptopurine; Methotrexate; Mitoxantrone; Osteonecrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Risk Factors; Treatment Outcome; Vincristine | 2001 |
High level resistance to glucocorticoids, associated with a dysfunctional glucocorticoid receptor, in childhood acute lymphoblastic leukemia cells selected for methotrexate resistance.
Topics: Active Transport, Cell Nucleus; Alleles; Antineoplastic Agents; Child; Cytarabine; Dexamethasone; DNA Mutational Analysis; DNA, Neoplasm; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glucocorticoids; Humans; Leukemia, T-Cell; Methotrexate; Neoplasm Proteins; Neoplastic Stem Cells; Polymorphism, Restriction Fragment Length; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Receptors, Glucocorticoid; RNA, Messenger; RNA, Neoplasm; Selection, Genetic; Sequence Analysis, DNA; Tumor Cells, Cultured | 2001 |
Delay of the diagnostic lumbar puncture and intrathecal chemotherapy in children with acute lymphoblastic leukemia who undergo routine corticosteroid testing: Tokyo Children's Cancer Study Group study L89-12.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Disease-Free Survival; Drug Screening Assays, Antitumor; Female; Follow-Up Studies; Glucocorticoids; Humans; Infant; Injections, Spinal; Japan; Life Tables; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Proportional Hazards Models; Risk; Sensitivity and Specificity; Spinal Puncture; Time Factors; Treatment Outcome | 2001 |
The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Child; Child, Preschool; Core Binding Factor Alpha 2 Subunit; Female; Humans; Infant; Lymphocytes; Male; Methotrexate; Oncogene Proteins, Fusion; Ploidies; Polyglutamic Acid; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Translocation, Genetic | 2001 |
Long-term effects on the intelligence of children treated for acute lymphoblastic leukemia.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Follow-Up Studies; Humans; Intelligence; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Recurrence; Survivors; Time Factors; Wechsler Scales | 2001 |
Repeated achilles tendinitis after high dose methotrexate.
Topics: Achilles Tendon; Adolescent; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Risk Factors; Tendinopathy | 2001 |
[Treatment of acute lymphoblastic leukemia in adults as an unsolved problem].
Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Dexamethasone; Humans; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Time Factors; Vincristine | 2001 |
Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnormalities after allogeneic bone marrow transplantation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Clone Cells; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; DNA Damage; Female; Follow-Up Studies; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Mercaptopurine; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Time Factors; Transplantation Conditioning; Transplantation, Homologous; Vincristine | 2001 |
Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment.
Topics: Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Clinical Trials as Topic; Cytogenetic Analysis; Disease-Free Survival; Down Syndrome; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Infant; Male; Methotrexate; Patient Selection; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Survival Rate | 2001 |
MR findings in Balint's syndrome, following intrathecal methotrexate and cytarabine therapy in adult acute lymphoblastic leukemia.
Topics: Adult; Brain; Cytarabine; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Neurologic Examination; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Disorders; Syndrome | 2001 |
Prognostic impact of CD45 antigen expression in high-risk, childhood B-cell precursor acute lymphoblastic leukemia.
Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; B-Lymphocytes; Child; Disease-Free Survival; Doxorubicin; Humans; Immunophenotyping; Leukocyte Common Antigens; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Time Factors; Vincristine | 2001 |
Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers.
Topics: Amino Acid Substitution; B-Lymphocytes; Base Sequence; Biological Transport; Carrier Proteins; Child; DNA Mutational Analysis; DNA, Complementary; DNA, Neoplasm; Gene Frequency; Humans; K562 Cells; Membrane Transport Proteins; Methotrexate; Mutagenesis, Insertional; Plasmids; Point Mutation; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; RNA, Neoplasm; Stem Cells; Transfection | 2001 |
Report of a patient with a high level of parathyroid hormone-related peptide associated with malignant lymphoma involving multiple bony lesions.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Hypercalcemia; Kidney; Methotrexate; Parathyroid Hormone-Related Protein; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteins | 2002 |
Ventral polyradiculopathy with pediatric acute lymphocytic leukemia.
Topics: Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cytarabine; Electromyography; Female; Humans; Hydrocortisone; Injections, Spinal; Magnetic Resonance Imaging; Methotrexate; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2002 |
Adult lymphoblastic lymphoma in Taiwan: an analysis of treatment results of 26 patients.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Cyclophosphamide; Doxorubicin; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Mechlorethamine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Procarbazine; Prognosis; Recurrence; Retrospective Studies; Survival Analysis; Taiwan; Treatment Outcome; Vincristine | 2001 |
Late effects of anticancer therapy on kidney function in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Kidney; Kidney Function Tests; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 2001 |
Thiopurine methyl transferase: activity and genotyping in patients with acute lymphoblastic leukemia.
Topics: Alleles; Antimetabolites, Antineoplastic; Child; Female; Genetic Testing; Genotype; Humans; Male; Mercaptopurine; Methotrexate; Methyltransferases; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2000 |
[Effective treatment with Lamivudine of patients with reactivation of hepatitis B following chemotherapy administration].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Reverse Transcriptase Inhibitors; Vincristine; Virus Activation | 2001 |
Toxic epidermal necrolysis in a girl with leukemia receiving methotrexate.
Topics: Child; Female; Follow-Up Studies; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Assessment; Severity of Illness Index; Stevens-Johnson Syndrome | 2001 |
Effect of methotrexate polyglutamates on thioguanine nucleotide concentrations during continuation therapy of acute lymphoblastic leukemia with mercaptopurine.
Topics: Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Child; Drug Administration Schedule; Erythrocytes; Humans; Hypoxanthine Phosphoribosyltransferase; Inactivation, Metabolic; Injections, Intravenous; Inosine Monophosphate; Mercaptopurine; Methotrexate; Methyltransferases; Neoplasm Proteins; Nucleotides; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Thioguanine; Thionucleotides; Xanthine Oxidase | 2002 |
Massive haemolysis in a group A recipient of a group O peripheral blood stem cell allogeneic transplant.
Topics: ABO Blood-Group System; Adult; B-Lymphocytes; Blood Cells; Blood Donors; Blood Group Incompatibility; Hematopoietic Stem Cell Transplantation; Hemolysis; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rh-Hr Blood-Group System; Transplantation Immunology; Transplantation, Homologous | 2001 |
Childhood acute lymphoblastic leukemia: prognostic value of initial peripheral blast count in good responders to prednisone.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Child; Child, Preschool; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Infant; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Survival Rate; Treatment Outcome | 2001 |
Nephrotoxicity due to intermediate-dose methotrexate without rescue in an obese adolescent with acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Humans; Kidney Diseases; Leucovorin; Male; Methotrexate; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radioisotope Renography | 2002 |
Chemotherapy related fatal neurotoxicity during induction in acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Dexamethasone; Fatal Outcome; Humans; Male; Methotrexate; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 2002 |
Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia.
Topics: Child; Humans; Methotrexate; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase; Treatment Outcome; Trinucleotide Repeats | 2002 |
Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; DNA, Neoplasm; Drug Resistance; Genotype; Heterozygote; Homozygote; Humans; Infant; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2002 |
Treatment of infants with lymphoblastic leukaemia: results of the UK Infant Protocols 1987-1999.
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Central Nervous System Diseases; Chi-Square Distribution; Disease-Free Survival; Female; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Injections, Spinal; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Survival Rate; United Kingdom | 2002 |
CNS late-effects after ALL therapy in childhood. Part III: neuropsychological performance in long-term survivors of childhood ALL: impairments of concentration, attention, and memory.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Attention; Brain Neoplasms; Central Nervous System; Child; Child, Preschool; Cognition Disorders; Cranial Irradiation; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Intelligence Tests; Male; Memory Disorders; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 2002 |
Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistance.
Topics: Antimetabolites, Antineoplastic; Blood Cells; Bone Marrow Cells; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Infant; Infant, Newborn; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2002 |
No major cognitive impairment in young children with acute lymphoblastic leukemia using chemotherapy only: a prospective longitudinal study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Attention; Child, Preschool; Cognition Disorders; Cyclophosphamide; Cytarabine; Dexamethasone; Female; Follow-Up Studies; Humans; Ifosfamide; Injections, Spinal; Learning Disabilities; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; Netherlands; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Survivors; Teniposide; Treatment Outcome; Vincristine | 2002 |
Pediatric acute lymphoblastic leukemia: redefining outcomes.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Attention; Child; Child, Preschool; Cognition Disorders; Combined Modality Therapy; Cranial Irradiation; Cytarabine; Dexamethasone; Drug Administration Routes; Humans; Hydrocortisone; Infant; Learning Disabilities; Memory Disorders; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Survivors; Treatment Outcome | 2002 |
Expression of P53 and bcl-2 proteins in T-cell lymphoblastic lymphoma: prognostic implications.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Disease-Free Survival; Etoposide; Female; Humans; Ifosfamide; Immunohistochemistry; Logistic Models; Longitudinal Studies; Male; Methotrexate; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proto-Oncogene Proteins c-bcl-2; Recurrence; Retrospective Studies; Survival Analysis; Tumor Suppressor Protein p53; Vincristine | 2002 |
CD56 expression predicts occurrence of CNS disease in acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Marrow Cells; CD56 Antigen; Cell Adhesion; Central Nervous System; Chemotaxis, Leukocyte; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Gene Expression; Humans; Incidence; Leukemic Infiltration; Life Tables; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm Proteins; Neoplastic Stem Cells; Neurons; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Risk; Survival Analysis; Treatment Outcome; Vincristine | 2002 |
Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Administration Schedule; Etoposide; Female; Humans; Immunophenotyping; Male; Mercaptopurine; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Treatment Outcome; Vincristine | 2002 |
[High risk acute lymphoblastic leukaemia in children. Preliminary report after introducing a new version of New York (1997) protocol adjusted to the age of the patients. Report of the Polish Paediatric Leukaemia/Lymphoma Study Group].
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Infant; Infant, Newborn; Male; Methotrexate; Multicenter Studies as Topic; Poland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Retrospective Studies; Risk Factors; Thioguanine; Time Factors; Treatment Outcome; Vincristine | 2000 |
Radiation myelitis in a 5-year-old girl.
Topics: Child, Preschool; Chronic Disease; Female; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Methotrexate; Muscle, Skeletal; Myelitis; Necrosis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Dosage; Radiation Injuries; Radiculopathy; Radiotherapy | 2002 |
Urate-oxidase in the prevention and treatment of metabolic complications in patients with B-cell lymphoma and leukemia, treated in the Société Française d'Oncologie Pédiatrique LMB89 protocol.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; France; Humans; Hydrocortisone; Leucovorin; Lymphoma, B-Cell; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retrospective Studies; Risk Assessment; Sensitivity and Specificity; Survival Rate; Treatment Outcome; Tumor Lysis Syndrome; Urate Oxidase; Vincristine | 2002 |
Complications of tumour overkill when associated with high dose methotrexate therapy.
Topics: Adolescent; Adult; Calcium; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Phosphates; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1979 |
Cytomegalovirus infection in children with blood diseases.
Topics: Adolescent; Anemia, Aplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Cytomegalovirus Infections; Daunorubicin; Female; gamma-Globulins; Humans; Immune Tolerance; Immunization, Passive; Infant; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Thioguanine; Vincristine | 1992 |
Bone marrow necrosis and human parvovirus associated infection preceding an Ph1+ acute lymphoblastic leukemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cyclophosphamide; Daunorubicin; Erythema Infectiosum; Female; Humans; Karyotyping; Methotrexate; Pancytopenia; Parvovirus B19, Human; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Steroids; Vincristine | 1992 |
Analyses of salivary components in leukemia patients receiving chemotherapy.
Topics: Adolescent; Adult; Aged; Amylases; Analysis of Variance; Antibiotics, Antineoplastic; Antineoplastic Agents; Child; Chlorhexidine; Cyclophosphamide; Female; Granulocytes; Humans; Immunoglobulin A, Secretory; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Methotrexate; Middle Aged; Peroxidases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Saliva; Salivary Proteins and Peptides; Secretory Rate; Thiocyanates; Vincristine | 1992 |
Impairment of cerebral biogenic amine synthesis in a patient receiving high-dose methotrexate.
Topics: Adolescent; Biogenic Amines; Biopterins; Brain; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1992 |
Defective transport as a mechanism of acquired resistance to methotrexate in patients with acute lymphocytic leukemia.
Topics: Adolescent; Adult; Aged; Biological Transport; Child; Child, Preschool; Drug Resistance; Female; Humans; Infant; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Trimetrexate; Tumor Cells, Cultured | 1992 |
Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Child; Child, Preschool; Chromosome Aberrations; Diploidy; Female; Humans; Infant; Lymphocytes; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S Phase | 1992 |
[Treatment of elderly patients with hematological malignancies].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Etoposide; Hodgkin Disease; Humans; Leucovorin; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Methotrexate; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prednisone; Vincristine | 1992 |
Etoposide, ifosfamide, and methotrexate combination chemotherapy for aggressive non-Hodgkin's lymphomas after failure of the LNH 84 regimen.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow; Cyclophosphamide; Doxorubicin; Etoposide; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Salvage Therapy; Vindesine | 1992 |
Substitutive therapy in a case of methotrexate neurotoxicity.
Topics: Brain Diseases; Child, Preschool; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1992 |
Transient neurologic disturbances in a child treated with moderate-dose methotrexate.
Topics: Brain; Cerebrovascular Disorders; Child; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Magnetic Resonance Imaging; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed | 1992 |
Relation of 5'-nucleotidase and phosphatase activities with immunophenotype, drug resistance and clinical prognosis in childhood leukemia.
Topics: 5'-Nucleotidase; Acid Phosphatase; Adolescent; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Daunorubicin; Drug Resistance; Female; Humans; Immunophenotyping; Infant; Leukemia, B-Cell; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Vincristine | 1992 |
White matter changes in children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Injections, Spinal; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy | 1992 |
Effect of high-dose methotrexate on plasma hypoxanthine and uridine levels in patients with acute leukemia or non-Hodgkin lymphoma in childhood.
Topics: Adolescent; Child; Humans; Hypoxanthine; Hypoxanthines; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Uridine | 1992 |
N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
Topics: Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; Thymidylate Synthase; Trimetrexate; Tumor Cells, Cultured | 1992 |
[Burgdorf's reaction (painful acral erythema) in patients with acute lymphoblastic leukemia following medium-dose methotrexate therapy].
Topics: Child, Preschool; Dose-Response Relationship, Drug; Erythema; Female; Hand Dermatoses; Humans; Infusions, Intravenous; Male; Methotrexate; Pain; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1992 |
Pattern of 6-mercaptopurine urinary excretion in children with acute lymphoblastic leukemia: urinary assays as a measure of drug compliance.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Circadian Rhythm; Drug Administration Schedule; Humans; Mercaptopurine; Methotrexate; Patient Compliance; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1992 |
A comparison of neuropsychological and psychosocial functioning after prophylactic treatment for childhood leukemia in monozygotic twins.
Topics: Affective Symptoms; Attention; Child; Female; Humans; Injections, Spinal; Language Tests; Leukemic Infiltration; Memory; Methotrexate; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Twins, Monozygotic; Verbal Learning; Wechsler Scales | 1992 |
The BFM-protocol for HIV-negative Burkitt's lymphomas and L3 ALL in adult patients: a high chance for cure.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Central Nervous System Diseases; Female; HIV Seropositivity; Humans; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 1992 |
Chronopharmacology of methotrexate pharmacokinetics in childhood leukemia.
Topics: Child; Child, Preschool; Circadian Rhythm; Drug Administration Schedule; Female; Humans; Kidney; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1992 |
Analysis of growth failure in children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Anthropometry; Antineoplastic Combined Chemotherapy Protocols; Body Height; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Growth Disorders; Humans; Incidence; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Puberty, Delayed; Radiation Injuries; Remission Induction; Risk Factors | 1992 |
[Studies of methotrexate pharmacokinetics in children with neoplasms of the hematopoietic system after administration of different doses of the drug].
Topics: Administration, Oral; Adolescent; Age Factors; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Half-Life; Humans; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1992 |
[Cerebrospinal fluid methotrexate level in children treated with medium-high and high doses of the drug].
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1992 |
Therapeutic gain with hyperfractionation in prophylactic cranial irradiation of children with acute lymphoblastic leukemia.
Topics: Brain Neoplasms; Child; Combined Modality Therapy; Humans; Intelligence; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Radiotherapy Dosage; Survival Analysis | 1992 |
Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Central Nervous System Neoplasms; Cerebral Cortex; Child; Child, Preschool; Female; Humans; Injections, Intravenous; Injections, Spinal; Lymphoma; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies | 1992 |
Management of children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols. An update of the Ontario experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cohort Studies; Cranial Irradiation; Cytarabine; Daunorubicin; Doxorubicin; Humans; Infant; Life Tables; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Remission Induction; Risk; Survival Analysis; Survival Rate; Treatment Outcome; Vincristine | 1992 |
[Analysis of lymphocyte surface markers in childhood acute lymphoblastic leukemia during maintenance chemotherapy].
Topics: Antigens, Surface; Antineoplastic Combined Chemotherapy Protocols; CD4-CD8 Ratio; Child; HLA-DR Antigens; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Interleukin-2; Remission Induction; T-Lymphocyte Subsets | 1992 |
Comparison of a new high-performance liquid chromatography method with fluorescence polarization immunoassay for analysis of methotrexate.
Topics: Child; Chromatography, High Pressure Liquid; Fluorescence Polarization Immunoassay; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Spectrophotometry, Ultraviolet | 1992 |
Rational use of methotrexate in maintenance therapy of childhood acute lymphoblastic leukemia.
Topics: Administration, Oral; Animals; Biological Availability; Child; Humans; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Rats, Inbred Strains | 1992 |
Cerebrospinal fluid exchange after intrathecal methotrexate overdose. A report of two cases.
Topics: Cerebrospinal Fluid; Child; Child, Preschool; Drug Overdose; Humans; Injections, Spinal; Male; Medication Errors; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sodium Chloride; Spinal Puncture | 1992 |
Cranial computed tomographic findings in children with newly diagnosed acute lymphoblastic leukemia: a prospective follow-up study during treatment.
Topics: Adolescent; Brain; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Female; Follow-Up Studies; Humans; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Tomography, X-Ray Computed | 1992 |
An HIV positive haemophiliac with acute lymphoblastic leukaemia successfully treated with intensive chemotherapy and syngeneic bone marrow transplantation.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Hemophilia A; HIV Seropositivity; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1992 |
[Late recurrence (11 years) in a case of ALL. Recurrence or a second disease?].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Central Nervous System Neoplasms; Diagnosis, Differential; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Time Factors; Vincristine | 1992 |
Use of a synthetic protease inhibitor for the treatment of L-asparaginase-induced acute pancreatitis complicated by disseminated intravascular coagulation.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamidines; Cyclophosphamide; Disseminated Intravascular Coagulation; Female; Gabexate; Guanidines; Humans; Male; Methotrexate; Pancreatitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Protease Inhibitors; Vincristine | 1992 |
Serum methotrexate in childhood ALL.
Topics: Child; Half-Life; Humans; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Treatment Outcome | 1992 |
Maintenance chemotherapy and cure of childhood acute lymphoblastic leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bone Marrow; Child; Humans; Long-Term Care; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Analysis | 1991 |
A human leukemia cell line made resistant to two folate analogues, trimetrexate and N10-propargyl-5,8-dideazafolic acid (CB3717).
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Cisplatin; Cross Reactions; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etoposide; Fluorouracil; Folic Acid; Humans; Leucovorin; Membrane Glycoproteins; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinazolines; RNA, Messenger; Thymidylate Synthase; Trimetrexate; Vincristine | 1991 |
Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Lymphocytes; Male; Methotrexate; Peptides; Pilot Projects; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 1990 |
Intensive chemotherapy for adult lymphoblastic lymphomas.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Dexamethasone; Doxorubicin; Female; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine | 1991 |
Enhancement of etoposide and methotrexate sensitivity by indomethacin in vitro.
Topics: Animals; Bleomycin; Drug Synergism; Etoposide; Humans; Indomethacin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lipoxygenase Inhibitors; Lung Neoplasms; Lymphoma; Methotrexate; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostaglandins; Protein Kinase Inhibitors; Tumor Cells, Cultured | 1991 |
Basis for natural resistance to methotrexate in human acute non-lymphocytic leukemia.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Resistance; Humans; Infant; Leukemia, Myeloid, Acute; Methotrexate; Middle Aged; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1991 |
Behavioral effects of corticosteroids in children with acute lymphoblastic leukemia.
Topics: Age Factors; Analysis of Variance; Attention; Child; Child Behavior; Child, Preschool; Cytarabine; Depression; Doxorubicin; Drug Interactions; Emotions; Female; Humans; Infant; Interpersonal Relations; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prospective Studies; Sex Factors; Sleep; Vincristine | 1992 |
Unexpected acute neurologic toxicity in the treatment of children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Etoposide; Female; Humans; Infant; Leucovorin; Male; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1992 |
Results of the LMT81 protocol, a modified LSA2L2 protocol with high dose methotrexate, on 84 children with non-B-cell (lymphoblastic) lymphoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Drug Administration Schedule; Female; Humans; Infant; Male; Methotrexate; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Survival Analysis; Vincristine | 1992 |
Isolated breast relapse after allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Child; Female; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 1992 |
[The analysis of leukemic relapse after allogeneic bone marrow transplantation].
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Cyclosporine; Female; Graft vs Host Disease; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Methotrexate; Postoperative Complications; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Transplantation, Homologous | 1991 |
[Clinical evaluation of severe toxicity in two patients with acute lymphoblastic leukemia receiving outpatient methotrexate therapy].
Topics: Acute Kidney Injury; Bone Marrow; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
[Treatment of acute lymphoblastic leukemia in children according to the Berlin-Frankfurt-Münster Program].
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Humans; Methotrexate; Multicenter Studies as Topic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Risk Factors; Time Factors | 1991 |
Aminoterminal propeptide of type III procollagen in cerebrospinal fluid. Variation with age and in childhood leukemia.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Peptide Fragments; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Procollagen; Radioimmunoassay | 1991 |
[Early neurotoxicity of high-dose of methotrexate and tetrahydrobiopterin deficiency].
Topics: Biopterins; Child; Humans; Male; Methotrexate; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
Decrease in number of CD16(Leu 11)+CD45RA(2H4)+ cells and defective production of natural killer cytotoxic factor in childhood acute lymphoblastic leukemia.
Topics: Adult; Antigens, CD; Antigens, Differentiation; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; CD8 Antigens; Child; Cytotoxicity, Immunologic; Dexamethasone; Flow Cytometry; Histocompatibility Antigens; HLA-DR Antigens; Humans; Killer Cells, Natural; Killer Factors, Yeast; Leukocyte Common Antigens; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Protein Biosynthesis; Proteins; Receptors, Fc; Receptors, IgG; Vincristine | 1991 |
Schedule-dependent synergism and antagonism between methotrexate and 6-mercaptopurine in a human acute lymphoblastic cell line.
Topics: Cell Division; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1991 |
[The fate of children after discontinuation of treatment for acute lymphoblastic leukemia].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Female; Humans; Infant; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Sex Factors; Time Factors; Vincristine | 1991 |
Skin manifestation of extramedullary relapse in adult with acute lymphoblastic leukaemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Immunotherapy; Leukemic Infiltration; Mercaptopurine; Methotrexate; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Radiotherapy; Recurrence; Remission Induction; Skin; Vincristine | 1991 |
Immunization response varies with intensity of acute lymphoblastic leukemia therapy.
Topics: Antibodies, Bacterial; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Capsules; Bacterial Vaccines; Child; Child, Preschool; Cyclophosphamide; Daunorubicin; Diphtheria Antitoxin; Diphtheria Toxoid; Diphtheria-Tetanus Vaccine; Drug Combinations; Female; Haemophilus influenzae; Haemophilus Vaccines; Humans; Immunization; Immunization, Secondary; Male; Methotrexate; Polysaccharides, Bacterial; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Tetanus Antitoxin; Tetanus Toxoid; Vincristine | 1991 |
Carboxyterminal propeptide of type I procollagen in cerebrospinal fluid in childhood and in children with leukemia undergoing intrathecal treatment.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Injections, Spinal; Male; Methotrexate; Peptides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Procollagen | 1991 |
Priapism in a child with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Humans; Male; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Priapism; Remission Induction; Vincristine | 1991 |
Treatment of adult acute lymphoblastic leukemia with allogeneic bone marrow transplantation. Multivariate analysis of factors affecting acute graft-versus-host disease, relapse, and relapse-free survival.
Topics: Acute Disease; Adolescent; Adult; Bone Marrow Transplantation; Cyclosporins; Female; Graft vs Host Disease; Histocompatibility; HLA Antigens; Humans; Incidence; Male; Methotrexate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Homologous | 1991 |
2,4-diamino-7-hydroxy-pteridines, a new class of catabolites of methotrexate.
Topics: Adolescent; Adult; Animals; Biotransformation; Child; Child, Preschool; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hodgkin Disease; Humans; Liver; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pteridines; Rabbits; Rats | 1991 |
The F-MACHOP regimen in advanced diffuse aggressive lymphomas: summary of ten years' experience at a single institution.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Fluorouracil; Humans; Leucovorin; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 1991 |
Cognitive function in children with leukemia. Effect of radiation dose and time since irradiation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Central Nervous System Neoplasms; Child; Child, Preschool; Cognition; Combined Modality Therapy; Cranial Irradiation; Educational Status; Female; Humans; Infant; Intelligence; Male; Methotrexate; Motor Skills; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy Dosage; Remission Induction; Time Factors | 1991 |
Secondary acute non-lymphocytic leukemia with monosomy 7 arising 9 years after acute lymphoblastic leukemia in childhood.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child, Preschool; Chromosomes, Human, Pair 7; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Methotrexate; Monosomy; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy | 1991 |
Raised plasma methotrexate concentrations following intrathecal administration in children with renal dysfunction.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Female; Half-Life; Humans; Injections, Spinal; Kidney Diseases; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
Plasma homocysteine in children with acute lymphoblastic leukemia: changes during a chemotherapeutic regimen including methotrexate.
Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Infant; Male; Methionine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1991 |
Hemiparesis and ischemic changes of the white matter after intrathecal therapy for children with acute lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Child, Preschool; Dysarthria; Female; Hemiplegia; Humans; Injections, Spinal; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed | 1991 |
Cranial nerve palsy in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
Topics: Child; Child, Preschool; Combined Modality Therapy; Cranial Nerve Diseases; Female; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Radiotherapy Dosage; Sex Factors; Survival Analysis | 1991 |
Effect of nitrous oxide and methotrexate on folate coenzyme pools of blast cells from leukemia patients.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Myeloid, Acute; Methotrexate; Nitrous Oxide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Vitamin B 12 | 1991 |
[Abnormally high methotrexate levels in the cerebrospinal fluid after intravenous and intrathecal treatment for acute lymphoblastic leukemia].
Topics: Child; Child, Preschool; Humans; Infusions, Intravenous; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
[L-asparaginase-induced hyperlipidemia in a case of acute lymphoblastic leukemia].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Dexamethasone; Female; Humans; Hyperlipidemias; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 1991 |
[Serum monitoring of methotrexate (MTX) and 7-hydroxymethotrexate concentrations in patients treated with MTX using high-pressure liquid chromatography (HPLC) and comparison of serum MTX levels between HPLC method and fluorescence polarization immunoassay
Topics: Adult; Aged; Child, Preschool; Chromatography, High Pressure Liquid; Female; Fluorescence Polarization Immunoassay; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
A longitudinal study of growth and growth hormone secretion in children during treatment for acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Body Height; Body Weight; Child; Child, Preschool; Combined Modality Therapy; Dexamethasone; Female; Glucocorticoids; Growth; Growth Hormone; Humans; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiotherapy Dosage; Vincristine | 1991 |
[High-dose methotrexate and hyperphenylalaninemia].
Topics: Adolescent; Biopterins; Child; Child, Preschool; Humans; Hydroxylation; Lymphoma, Non-Hodgkin; Methotrexate; Phenylalanine; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
Pharmacokinetic study of methotrexate, folinic acid and their serum metabolites in children treated with high-dose methotrexate and leucovorin rescue.
Topics: Child; Child, Preschool; Chromatography, High Pressure Liquid; Half-Life; Humans; Leucovorin; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
Memory and learning sequelae in long-term survivors of acute lymphoblastic leukemia: association with attention deficits.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Attention; Brain Diseases; Calcinosis; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Humans; Injections, Spinal; Learning Disabilities; Memory Disorders; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, High-Energy; Tomography, X-Ray Computed; Verbal Learning | 1990 |
Methotrexate sensitivity in Down's syndrome: a hypothesis.
Topics: Down Syndrome; Drug Tolerance; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
[Preparation and cytotoxicity of McAb-HSA-MTX conjugates].
Topics: Albumins; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cytotoxicity Tests, Immunologic; Humans; Immunotoxins; Leukemia, Lymphoid; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1990 |
Acute respiratory failure after intrathecal methotrexate administration.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infant; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Respiratory Insufficiency; Teniposide | 1990 |
High dose cytosine arabinoside in the initial treatment of adults with acute lymphoblastic leukaemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Humans; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine | 1990 |
An animal model to study toxicity of central nervous system therapy for childhood acute lymphoblastic leukemia: effects on growth and craniofacial proportion.
Topics: Animals; Cephalometry; Combined Modality Therapy; Female; Growth; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiotherapy; Rats; Rats, Inbred Strains; Skull | 1990 |
An animal model to study toxicity of central nervous system therapy for childhood acute lymphoblastic leukemia: effects on behavior.
Topics: Animals; Behavior, Animal; Brain; Cognition Disorders; Combined Modality Therapy; Female; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Radiotherapy; Rats; Rats, Inbred Strains; Sex Characteristics | 1990 |
[Treatment of acute lymphoblastic leukemia in adults by the modified protocol of L-10M (Sloan-Kettering)].
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Humans; Male; Methotrexate; Methylprednisolone; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Survival Rate; Vincristine | 1990 |
[Effect of high-dose methotrexate on cerebral metabolic rate of glucose in rats and children with acute lymphoblastic leukemia].
Topics: Adolescent; Age Factors; Animals; Brain; Child; Child, Preschool; Female; Glucose; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Rats, Inbred Strains | 1990 |
Successful treatment of acute leukemia with t(4;11) in an infant with congenital hypothyroidism.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 4; Congenital Hypothyroidism; Cranial Irradiation; Cytarabine; Doxorubicin; Etoposide; Female; Humans; Hypothyroidism; Infant; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Translocation, Genetic; Vincristine | 1990 |
[Transient dysfibrinogenemia and cerebral thrombosis following remission induction therapy for acute lymphoblastic leukemia].
Topics: Adult; Afibrinogenemia; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Female; Humans; Intracranial Embolism and Thrombosis; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine | 1990 |
Multiagent chemotherapy in relapsed acute lymphoblastic leukemia in children.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cytarabine; Daunorubicin; Female; Humans; Hydrocortisone; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Recurrence; Remission Induction; Teniposide; Vincristine | 1990 |
7-Hydroxymethotrexate concentrations in serum and cerebrospinal fluid of children with acute lymphoblastic leukemia.
Topics: Aging; Antineoplastic Agents; Child; Child, Preschool; Folic Acid Antagonists; Humans; Infant; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 1990 |
[High methotrexate doses in the treatment program for acute lymphoblastic leukemia and lymphosarcoma in children].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Evaluation; Drug Tolerance; Female; Humans; Infant; Leucovorin; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Time Factors | 1990 |
'MACHO' chemotherapy for stage IV B cell lymphoma and B cell acute lymphoblastic leukaemia of childhood. United Kingdom Children's Cancer Study Group (UKCCSG).
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Leucovorin; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Vincristine | 1990 |
Maintenance chemotherapy for childhood acute lymphoblastic leukemia: should dosage be guided by white blood cell counts?
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Retrospective Studies; Risk Factors | 1990 |
Cognitive functioning in long-term survivors of childhood leukemia: a prospective analysis.
Topics: Adolescent; Brain; Child; Combined Modality Therapy; Cranial Irradiation; Education, Special; Female; Follow-Up Studies; Humans; Injections, Spinal; Intelligence; Learning Disabilities; Longitudinal Studies; Male; Methotrexate; Neurocognitive Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiation Injuries; Radiotherapy Dosage; Substance-Related Disorders; Wechsler Scales | 1990 |
Biochemical and growth inhibition studies of methotrexate and aminopterin analogues containing a tetrazole ring in place of the gamma-carboxyl group.
Topics: Aminopterin; Animals; Biological Transport; Cell Division; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Humans; Leucovorin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Liver; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
Cryptosporidiosis and acute leukaemia.
Topics: Child; Child, Preschool; Cryptosporidiosis; Female; Humans; Immunosuppression Therapy; Infant; Male; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spiramycin | 1990 |
Biochemical evidence for synergistic combination treatment with methotrexate and 6-mercaptopurine in acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; DNA, Neoplasm; Drug Synergism; Humans; Lymphocytes; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thymidine; Tumor Cells, Cultured | 1990 |
Pharmacokinetics of folinic acid in children with acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Brain Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Evaluation; Female; Humans; Hydrocortisone; Infant; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Spinal Cord Neoplasms; Testicular Neoplasms | 1990 |
Sex differences in cognitive processing in children treated with CNS prophylaxis for acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain; Child; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Methotrexate; Neurocognitive Disorders; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Substance-Related Disorders | 1990 |
Serum immunoreactive erythropoietin in children with acute leukaemia at various stages of disease--and the effects of treatment.
Topics: Adolescent; Anemia; Child; Child, Preschool; Cytarabine; Dose-Response Relationship, Drug; Erythropoietin; Female; Hemoglobins; Humans; Infant; Leukemia, Myeloid, Acute; Longitudinal Studies; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
Comparative study on the pharmacokinetics of 7-hydroxy-methotrexate after administration of methotrexate in the dose range of 0.5-33.6 g/m2 to children with acute lymphoblastic leukemia.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Drug Administration Schedule; Female; Half-Life; Humans; Infant; Kinetics; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Sex Factors | 1990 |
Prognostic significance of hepatotoxicity during maintenance chemotherapy for childhood acute lymphoblastic leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Female; Humans; Liver Diseases; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Transaminases | 1990 |
MTX clearance is more important for intermediate-risk ALL.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 1990 |
Pharmacokinetics of oral 6-mercaptopurine: relationship between plasma levels and urine excretion of parent drug.
Topics: Administration, Oral; Adolescent; Adult; Ascorbic Acid; Biological Availability; Child; Chromatography, High Pressure Liquid; Female; Glutathione; Humans; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1990 |
Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Prospective Studies; Recurrence; Remission Induction; Risk Factors; Survival Analysis; Xanthine Oxidase | 1990 |
Do visual evoked potentials detect neural damage in children treated for cancer?
Topics: Adolescent; Adult; Brain Diseases; Brain Neoplasms; Child; Child, Preschool; Evoked Potentials, Visual; Female; Follow-Up Studies; Humans; Male; Medulloblastoma; Methotrexate; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Radiotherapy | 1990 |
[Transverse leukonychia and anti-leukemia chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Child, Preschool; Cyclophosphamide; Cytarabine; Humans; Male; Methotrexate; Nail Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 1990 |
6-Thioguanine nucleotide accumulation in red blood cells during maintenance chemotherapy for childhood acute lymphoblastic leukemia, and its relation to leukopenia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dose-Response Relationship, Drug; Erythrocytes; Female; Guanine Nucleotides; Humans; Leukopenia; Male; Mercaptopurine; Methotrexate; Monitoring, Physiologic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides | 1990 |
[Acral nevi following chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Foot Diseases; Humans; Male; Mercaptopurine; Methotrexate; Nevus, Pigmented; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Skin Neoplasms | 1990 |
Contribution of mercaptopurine dose intensification to improved outcome in patients with lower-risk ALL.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors | 1990 |
CNS minimal disease therapy in childhood leukaemia: the place for irradiation.
Topics: Brain Neoplasms; Child; Child, Preschool; Humans; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy; Spinal Cord Neoplasms | 1990 |
Acute lymphoblastic leukemia; factors influencing relapse after allogeneic bone marrow transplantation.
Topics: Adolescent; Bone Marrow Transplantation; Combined Modality Therapy; Female; Graft vs Host Disease; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 1990 |
Diurnal variation in the pharmacokinetics and myelotoxicity of mercaptopurine in children with acute lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Circadian Rhythm; Drug Administration Schedule; Female; Half-Life; Humans; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Neutropenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
In vitro methotrexate polyglutamate formation is elevated in acute lymphoid leukemia cells compared with acute myeloid leukemia and normal bone marrow cells.
Topics: Adult; Bone Marrow; Humans; In Vitro Techniques; Leukemia; Leukemia, Myeloid, Acute; Methotrexate; Peptides; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
Liquoral myelin basic protein in acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Female; Humans; Male; Methotrexate; Middle Aged; Myelin Basic Protein; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Minimal neuropsychological sequelae following prophylactic treatment of the central nervous system in adult leukaemia and lymphoma.
Topics: Adult; Aged; Brain; Brain Neoplasms; Combined Modality Therapy; Electroencephalography; Female; Humans; Intelligence Tests; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Neuropsychological Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy, High-Energy; Spinal Cord Neoplasms | 1989 |
[Neurofibroma-associated left peroneal nerve palsy in a patient with acute lymphoblastic leukemia].
Topics: Child; Female; Humans; Lumbar Vertebrae; Methotrexate; Neoplasms, Multiple Primary; Neurofibroma; Paralysis; Peripheral Nervous System Diseases; Peroneal Nerve; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sacrum; Spinal Neoplasms; Vincristine | 1989 |
Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Erythrocytes; Humans; Leukocyte Count; Mercaptopurine; Methotrexate; Neutrophils; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Survival Analysis; Thioguanine | 1989 |
Disposition of oral methotrexate in children with acute lymphoblastic leukemia and its relation to 6-mercaptopurine pharmacokinetics.
Topics: Administration, Oral; Adolescent; Age Factors; Child; Child, Preschool; Female; Humans; Male; Mercaptopurine; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Maintenance chemotherapy for childhood acute lymphoblastic leukemia: relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Child; Child, Preschool; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Leukocyte Count; Liver; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Time Factors; Transaminases; Vincristine | 1989 |
Intrathecal methotrexate toxicity.
Topics: Adult; Female; Humans; Injections, Spinal; Methotrexate; Paraplegia; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Low-dose methotrexate-induced changes in intestinal permeability determined by polyethylene glycol polymers.
Topics: Adolescent; Animals; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Polyethylene Glycols; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
[Meningeal passage of folinic acid in treatment protocols using LAL with methotrexate in children].
Topics: Child, Preschool; Humans; Injections, Jet; Leucovorin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Sensitivity to purine analogues in childhood leukemia assessed by the automated MTT-assay.
Topics: Child; Coloring Agents; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thioguanine | 1989 |
The basis for intrinsic drug resistance or sensitivity to methotrexate.
Topics: Carcinoma, Squamous Cell; Drug Resistance; Head and Neck Neoplasms; Humans; Leukemia, Myeloid, Acute; Methotrexate; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Soft Tissue Neoplasms; Tumor Cells, Cultured | 1989 |
Skin rash after completion of therapy for leukemia in childhood.
Topics: Erythema; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Reinduction therapy for advanced or refractory acute lymphoblastic leukemia of childhood.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Combined Modality Therapy; Cytarabine; Drug Administration Schedule; Female; Humans; Infant; Male; Methotrexate; Mycoses; Platelet Count; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine | 1989 |
Induction of partial synchronization of leukemia cells by continuous infusion of low-dose methotrexate followed by citrovorum factor.
Topics: Bone Marrow; Child; Cytological Techniques; Humans; Infusions, Intravenous; Interphase; Leucovorin; Methotrexate; Myelodysplastic Syndromes; Pilot Projects; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
The significance of an isolated central nervous system relapse, occurring as first relapse in children with acute lymphoblastic leukemia.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Retrospective Studies; Time Factors | 1989 |
Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance.
Topics: Biological Transport; Carrier Proteins; Cell Division; Drug Resistance; Folate Receptors, GPI-Anchored; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Cell Surface; Tumor Cells, Cultured | 1989 |
Reversible treatment-related leukoencephalopathy.
Topics: Child; Child, Preschool; Cytarabine; Drug Synergism; Drug Therapy, Combination; Humans; Leukoencephalopathy, Progressive Multifocal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Acute leukemia presenting as a unilateral exudative retinal detachment.
Topics: Biopsy; Blood Cell Count; Bone Marrow Examination; Child; Cytarabine; Fluorescein Angiography; Humans; Hydrocortisone; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retinal Detachment; Visual Acuity | 1989 |
Cutaneous vasculitis after intermediate dose of methotrexate (IDMTX).
Topics: Adult; Drug Hypersensitivity; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vasculitis, Leukocytoclastic, Cutaneous | 1989 |
Intermediate-dose intravenous methotrexate and mercaptopurine therapy for non-T, non-B acute lymphocytic leukemia of childhood: a Pediatric Oncology Group study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Infusions, Intravenous; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Seizures | 1989 |
Chronopharmacokinetics of oral methotrexate and 6-mercaptopurine: is there diurnal variation in the disposition of antileukemic therapy?
Topics: Administration, Oral; Child; Circadian Rhythm; Drug Administration Schedule; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Evidence for CSF accumulation of 5-methyltetrahydrofolate during repeated courses of methotrexate plus folinic acid rescue.
Topics: Child; Child, Preschool; Female; Humans; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolates | 1989 |
Management of Ontario children with acute lymphoblastic leukemia by the Dana-Farber Cancer Institute protocols.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Boston; Child; Clinical Protocols; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Neoplasm Recurrence, Local; Ontario; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Survival Rate; Vincristine | 1989 |
Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions.
Topics: Adolescent; Adult; Burkitt Lymphoma; Child; Cysteine; Homocysteine; Humans; Infusions, Intravenous; Kinetics; Methionine; Methotrexate; Models, Theoretical; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
Oral mucositis and salivary methotrexate concentration in intermediate-dose methotrexate therapy for children with acute lymphoblastic leukemia.
Topics: Child; Child, Preschool; Female; Humans; Male; Methotrexate; Mouth Mucosa; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Saliva; Statistics as Topic; Time Factors | 1989 |
Variability in the disposition of intraventricular methotrexate: a proposal for rational dosing.
Topics: Adolescent; Burkitt Lymphoma; Child; Child, Preschool; Drug Implants; Humans; Injections, Intraventricular; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1989 |
[Isolated cerebral calcifications after prophylactic treatment of cerebromeningeal involvement of acute lymphoblastic leukemia: relation of psycho-intellectual sequelae].
Topics: Brain Diseases; Calcinosis; Child, Preschool; Female; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychotic Disorders; Radiotherapy; Tomography, X-Ray Computed | 1989 |
The role of 5'nucleotidase in therapy-resistance of childhood leukemia.
Topics: 5'-Nucleotidase; Child, Preschool; Drug Resistance; Humans; Infant; Mercaptopurine; Methotrexate; Nucleotidases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleosides; Purine Nucleotides | 1988 |
Behavioral side-effects of CNS prophylaxis.
Topics: Adolescent; Brain; Humans; Intelligence; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiography | 1989 |
[Use of methotrexate in a child with trisomy 21. Value of blood levels].
Topics: Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Down Syndrome; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
Cerebral glucose metabolic change after high-dose methotrexate treatment in patients with acute lymphocytic leukemia.
Topics: Adolescent; Brain; Child; Child, Preschool; Female; Glucose; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, Emission-Computed | 1986 |
[Intravenous immunoglobulin preparations in the adjuvant treatment of acute lymphoblastic leukemia in children].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Humans; Immunization, Passive; Immunoglobulin G; Immunoglobulins, Intravenous; Infant; Infusions, Intravenous; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Thioguanine; Vincristine | 1988 |
Disturbed pubertal growth in girls treated for acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Body Height; Child; Child, Preschool; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Female; Growth Disorders; Growth Hormone; Humans; Menarche; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Puberty; Vincristine | 1987 |
High-dose methotrexate therapy (6-8 g/m2) in childhood malignancies: clinical tolerability and pharmacokinetics.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation; Half-Life; Humans; Infusions, Intravenous; Leucovorin; Lymphoma, Non-Hodgkin; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Stomatitis; Vincristine | 1987 |
Convulsions and intracranial calcifications in a leukemic infant receiving only intrathecal methotrexate as central nervous system prophylaxis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Brain Diseases; Calcinosis; Cyclophosphamide; Doxorubicin; Humans; Infant; Injections, Spinal; Male; Meningeal Neoplasms; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Seizures; Vincristine | 1987 |
Thyroid function in children after cytostatic treatment for acute leukemia.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thyroid Diseases | 1988 |
Methotrexate concentration levels in the cerebrospinal fluid during high-dose methotrexate infusions: an unreliable prediction.
Topics: Adolescent; Blood-Brain Barrier; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
White cell count during maintenance chemotherapy for standard-risk childhood acute lymphoblastic leukemia: relation to relapse rate.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Humans; Leukocyte Count; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Recurrence; Remission Induction; Retrospective Studies; Risk Factors | 1988 |
Prognosis after relapse in acute lymphoblastic leukemia in childhood.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cranial Irradiation; Doxorubicin; Humans; Life Tables; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Survival Rate; Sweden; Vincristine | 1986 |
Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate after high-dose (33.6 g/m2) methotrexate therapy.
Topics: Child; Combined Modality Therapy; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Testicular Neoplasms | 1986 |
Childhood non-Hodgkin's lymphoma and "leukemia-lymphoma syndrome": long-term results with the modified LSA2-L2 protocol.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Daunorubicin; Diagnosis, Differential; Evaluation Studies as Topic; Humans; Italy; Life Tables; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Survival Rate; Syndrome; Vincristine | 1986 |
Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Contraindications; Drug Interactions; Drug Tolerance; Folic Acid; Humans; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis | 1986 |
[Effects of the use of cranial radiotherapy. Findings obtained by computerized axial tomography and intellectual function tests].
Topics: Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Female; Glioma; Humans; Infant; Lymphoma, Non-Hodgkin; Male; Medulloblastoma; Mental Processes; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tomography, X-Ray Computed | 1988 |
Leukoencephalopathy after prophylactic radiation for leukaemia in ataxia telangiectasia.
Topics: Ataxia Telangiectasia; Brain; Brain Diseases; Brain Neoplasms; Child, Preschool; Humans; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiotherapy | 1988 |
Pulsatile growth hormone secretion in children with acute lymphoblastic leukemia after 1800 cGy cranial radiation.
Topics: Adolescent; Body Height; Central Nervous System; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Growth Hormone; Humans; Male; Meningeal Neoplasms; Methotrexate; Periodicity; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
Pharmacokinetics of subcutaneous methotrexate.
Topics: Absorption; Administration, Oral; Adolescent; Adult; Animals; Child; Child, Preschool; Female; Humans; Injections, Subcutaneous; Macaca mulatta; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
[Combination of radio-chemotherapy for curing of childhood hematologic tumors: preventive approaches and problems on CNS involvement].
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Male; Meningeal Neoplasms; Methotrexate; Neoplasm Invasiveness; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis | 1988 |
Neuropsychological effects of irradiation and chemotherapy treatments upon children with acute lymphoblastic leukemia: a case study of monozygotic twins.
Topics: Adolescent; Cognition; Combined Modality Therapy; Diseases in Twins; Female; Follow-Up Studies; Humans; Intelligence Tests; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Twins; Twins, Monozygotic | 1988 |
[Long-term survival following acute lymphoblastic leukemia (ALL) in childhood].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 1988 |
Aggressive treatment improves survival in adult acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Blood Transfusion; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation; Humans; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Middle Aged; Nervous System Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Vincristine | 1988 |
Short-term intensive treatment (V.A.A.P.) of adult acute lymphoblastic leukemia and lymphoblastic lymphoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cytarabine; Doxorubicin; Drug Evaluation; Female; Humans; Lymphoma, Non-Hodgkin; Male; Meningeal Neoplasms; Methotrexate; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Vincristine | 1988 |
[Meningeal involvement in ALL. Comparative study of 2 methods of protecting the CNS].
Topics: Central Nervous System Diseases; Child, Preschool; Combined Modality Therapy; Female; Humans; Injections, Intravenous; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
Twelve years experience with methotrexate infusions in childhood ALL.
Topics: Adolescent; Central Nervous System Diseases; Child; Child, Preschool; Humans; Infant; Infusions, Intravenous; Injections, Spinal; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
Treatment of high-risk acute lymphoblastic leukemia with protocols PETHEMA LAL 7/78 and LAL 17/84.
Topics: Adolescent; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Clinical Protocols; Cytarabine; Daunorubicin; Female; Humans; Infant; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine | 1988 |
CNS relapse in children with acute lymphoblastic leukemia after cranial prophylaxis.
Topics: Adolescent; Brain; Brain Neoplasms; Child; Child, Preschool; Female; Humans; Injections, Spinal; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Retrospective Studies; Spinal Cord Neoplasms | 1988 |
[Serial spectral EEG analysis in children treated with intermediate-dose methotrexate (ID-MTX)].
Topics: Brain; Child; Child, Preschool; Electroencephalography; Female; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
[Interstitial nephritis developed during maintenance chemotherapy in a child with acute lymphocytic leukemia].
Topics: Child; Humans; Male; Methotrexate; Nephritis, Interstitial; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction | 1988 |
[Epilepsy as a late sequela of therapy in acute lymphoblastic leukosis--case report].
Topics: Adolescent; Epilepsy; Female; Humans; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors | 1988 |
[Preliminary evaluation of the treatment of recurrences of acute lymphoblastic leukemia by the BFM (Henze) method].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Male; Methotrexate; Neoplasm Recurrence, Local; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Thioguanine; Time Factors; Vincristine | 1988 |
[Effect of prognostic factors on the course of acute lymphoblastic leukemia in children].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Doxorubicin; Female; Humans; Infant; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Thioguanine; Time Factors; Vincristine | 1988 |
[Pharmacokinetics of methotrexate in children with acute lymphoblastic leukemia].
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Female; Half-Life; Humans; Infant; Infusions, Intravenous; Leucovorin; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Vincristine | 1988 |
[Monitoring of methotrexate treatment of children with proliferative diseases of the hematopoietic system].
Topics: Adolescent; Child; Child, Preschool; Histiocytosis, Langerhans-Cell; Humans; Infusions, Intravenous; Injections, Intravenous; Lymphoma; Methotrexate; Monitoring, Physiologic; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1988 |
Plasma protein fractions and alpha 1-acidglycoprotein as tumor markers in acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Biomarkers, Tumor; Blood Proteins; Brain Neoplasms; Doxorubicin; Humans; Mercaptopurine; Methotrexate; Orosomucoid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Vincristine | 1987 |