Page last updated: 2024-08-25

methotrexate and Abnormalities, Drug-Induced

methotrexate has been researched along with Abnormalities, Drug-Induced in 89 studies

Research

Studies (89)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (40.45)	18.7374
1990's	13 (14.61)	18.2507
2000's	22 (24.72)	29.6817
2010's	16 (17.98)	24.3611
2020's	2 (2.25)	2.80

Authors

Authors	Studies
Brennan, A; Bryant, JR; Goldrich, A; Mantilla-Rivas, E; Oh, AK; Rogers, GF	1
Hammad, I; Porter, TF	1
de Bruin-Weller, MS; Fidder, HH; Garritsen, FM; Spuls, PI; van den Broek, MPH; van Zuilen, AD	1
de Haan, E; Lindhout, D; van Haelst, MM; van Tintelen, JP; Verberne, EA	1
Beau-Salinas, F; Bejan-Angoulvant, T; Cissoko, H; Jonville-Béra, AP; Lengellé, C	1
Funakubo Asanuma, Y	1
Bernard, N; Bourneau-Martin, D; Carlier, P; Drablier, G; Lagarce, L; Lainé-Cessac, P; Perault-Pochat, MC; Phelipot-Lates, S	1
Beck, E; Berber, E; Gøtestam Skorpen, C; Hoeltzenbein, M; Rajwanshi, R; Schaefer, C; Østensen, M	1
Bijlsma, JW; Bombardier, C; Boumpas, DT; Canhao, H; Carmona, L; Dougados, M; Edwards, CJ; Hamuryudan, V; Katchamart, W; Kvien, TK; Leeb, BF; Loza, E; Martín-Mola, EM; Martinez-Lopez, JA; Mielants, H; Müller-Ladner, U; Murphy, G; Pereira, IA; Ramos-Remus, C; Salliot, C; Trudeau, J; Valentini, G; van der Heijde, D; Visser, K; Zochling, J; Østergaard, M	1
Salgo, R; Thaçi, D	1
DeCampli, W; Piggott, KD; Riddle, E; Sorbello, A	1
Jayranganath, M; Manjunath, CN; Subramanian, A	1
Kozma, C; Ramasethu, J	1
Einarson, A; Erebara, A; Finkelstein, Y; Johnson, D; Koren, G; Lavigne, SV; Moretti, ME; Nurmohamed, L; Schechter, T	1
Engeland, A; Furu, K; Viktil, KK	1
Hyoun, SC; Običan, SG; Scialli, AR	1
Guan, T; Guan, Z; Niu, B; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhao, J	1
Chaoui, R; Huch, A; Krähenmann, F; Stallmach, T; ØStensen, M	1
O'Meara, P; Stanford, M; Wheeler, M	1
Bacci, G; Longhi, A; Macchiagodena, M; Vitali, G	1
Ferrero, S; Ragni, N	1
Abramowicz, JS; Chapa, JB; Hibbard, JU; Verp, MS; Weber, EM	1
Buzzard, BO; Fort, DJ; McLaughlin, DL; Myers, NK; Noll, AM; Rogers, RL; Song, MO; Thomas, JH	1
Jones, KL; Kahole, NC; Vaux, KK	1
RODRIGUEZDEAGNESE, LR; YANZON, NA	1
CHITHAM, RG; MCIVER, EJ	1
Ferrero, S; Pretta, S; Ragni, N	1
Addar, MH	1
Carlier, P; Descotes, J; Elefant, E; Lewden, B; Nelva, A; Vial, T	1
Carr, M; Hall, G; Hughes, R; Lloyd, M; McElhatton, P	1
Abdulbasit, OB; Abdullah, MA; Abomelha, AM; Al Dohami, H; Babiker, M; Seidahmed, MZ; Shaheed, MM	1
Badgwell, C; Rosen, T	1
Gui, YH; Jiang, Q; Song, HY; Sun, SN; Wang, YX; Zhong, T	1
Affleck, JG; Walker, VK	1
Abu-Musa, AA; Nassar, AH; Usta, IM; Yunis, KA	1
Wolfgang, WJ	1
Arnold, HL; Bennett, JH; Maibach, HI; Rees, RB	1
Christophidis, N	1
Schmid, BP	1
Perry, WH	1
DePaola, DP; Mandella, RD	1
Donnenfeld, AE; Koren, G; Noah, JS; Pastuszak, A; Rose, NC; Schick, B	1
Tariq, S; Tariq, SM	1
Carey, JC; Feldkamp, M	1
Niebyl, JR; Yankowitz, J	1
Bermas, BL; Hill, JA	1
Johnson, EM	1
Buckley, LM; Bullaboy, CA; Leichtman, L; Marquez, M	1
Bawle, EV; Conard, JV; Weiss, L	1
Bennett, FC; Del Campo, M; Jones, KL; Kosaki, K	1
Feldman, SR; Fleischer, AB; Hotard, RS	1
Hartmann, H; Ostensen, M; Salvesen, K	1
Harada, M	1
Ross, GT	1
Bagshawe, KD; Walden, PA	1
Siddall, RA	1
Hoar, RM; McClain, RM; Woo, DC	1
Warkany, J	1
Becker, MH; Converse, JM; Cox, RP; Genieser, NB; McCarthy, JG; Reich, EW	1
Brock, R; Corradini, HB; Diniz, EM; Ramos, JL	1
Jaffe, N	1
Jordan, RL; Schumacher, HJ; Wilson, JG	1
DeSesso, JM; Jordan, RL	1
Khera, KS	1
Holm, O	1
Elmazar, MM; Nau, H	1
Snodgrass, SR	1
Bantle, JA; Bush, SJ; DeYoung, DJ; Fort, DJ; Rayburn, JR	1
DeSesso, JM; Goeringer, GC	1
Guillet, G; Plantin, P; Saraux, A	1
Darab, DJ; Minkoff, R; Sciote, J; Sulik, KK	1
Weinblatt, ME	1
Blessinger, GM	1
Miller, RW	1
Shepard, TH	1
Gastol-Lewińska, L	1
Panchalingam, S	1
Gold, MP; Skalko, RG	1
Baker, H	1
Kutsch Lojenga, JC	1
Curless, RG	1
Ekert, H; Powell, HR	1
Berry, CL	1
Gaynor, MF; Graef, JW; Milunsky, A	1

Reviews

23 review(s) available for methotrexate and Abnormalities, Drug-Induced

Article	Year
An Update on Biologic Agents During Pregnancy. Clinics in perinatology, 2020, Volume: 47, Issue:4 Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Autoimmune Diseases; Azathioprine; Biological Products; Cyclophosphamide; Cyclosporine; Female; Fetal Growth Retardation; Glucocorticoids; Humans; Hydroxychloroquine; Immunosuppressive Agents; Leflunomide; Methotrexate; Mycophenolic Acid; Pregnancy; Pregnancy Complications; Premature Birth; Rituximab; Sulfasalazine; Tumor Necrosis Factor Inhibitors	2020
Pregnancy and fetal outcomes after paternal exposure to azathioprine, methotrexate or mycophenolic acid: a critically appraised topic. The British journal of dermatology, 2017, Volume: 176, Issue:4 Topics: Abnormalities, Drug-Induced; Antibiotics, Antineoplastic; Azathioprine; Female; Humans; Immunosuppressive Agents; Infant, Low Birth Weight; Male; Methotrexate; Mycophenolic Acid; Paternal Exposure; Pregnancy; Pregnancy Complications; Pregnancy Outcome	2017
Fetal methotrexate syndrome: A systematic review of case reports. Reproductive toxicology (Elmsford, N.Y.), 2019, Volume: 87 Topics: Abnormalities, Drug-Induced; Antirheumatic Agents; Fetus; Humans; Methotrexate; Syndrome; Teratogens	2019
[Management of rheumatoid arthritis medications and pregnancy]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2015, Volume: 38, Issue:1 Topics: Abatacept; Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Contraindications; Etanercept; Female; Fertility; Humans; Infliximab; Methotrexate; Milk, Human; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Risk; Time Factors; Tumor Necrosis Factor-alpha; Young Adult	2015
Treatment of moderate-to-severe plaque psoriasis. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2009, Volume: 144, Issue:6 Topics: Abnormalities, Drug-Induced; Alefacept; Antibodies, Monoclonal; Clinical Trials as Topic; Contraindications; Cyclosporine; Etanercept; Female; Fumarates; Hematologic Diseases; Humans; Hypertension; Immunoglobulin G; Immunosuppressive Agents; Kidney Diseases; Male; Methotrexate; Photochemotherapy; Pregnancy; Pregnancy Complications; Psoriasis; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Retinoids; Severity of Illness Index; Tumor Necrosis Factor-alpha	2009
Teratogen update: methotrexate. Birth defects research. Part A, Clinical and molecular teratology, 2012, Volume: 94, Issue:4 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aminopterin; Animals; Female; Fetal Diseases; Folic Acid Antagonists; Humans; Methotrexate; Mice; Mice, Inbred C57BL; Pregnancy; Pregnancy Complications; Pregnancy, Ectopic; Rabbits; Rats; Rats, Sprague-Dawley; Teratogens; Tetrahydrofolate Dehydrogenase	2012
Inflammatory bowel disease: management issues during pregnancy. Archives of gynecology and obstetrics, 2004, Volume: 270, Issue:2 Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminosalicylic Acids; Anti-Bacterial Agents; Azathioprine; Breast Feeding; Contraindications; Cyclosporine; Female; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Maternal Nutritional Physiological Phenomena; MEDLINE; Mercaptopurine; Methotrexate; Pregnancy; Pregnancy Complications; Pregnancy Outcome	2004
Multiple sclerosis: management issues during pregnancy. European journal of obstetrics, gynecology, and reproductive biology, 2004, Jul-15, Volume: 115, Issue:1 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Breast Feeding; Cyclophosphamide; Delivery, Obstetric; Female; Humans; Labor, Obstetric; Methotrexate; Multiple Sclerosis; Postpartum Period; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prognosis; Recurrence	2004
Cutaneous sarcoidosis therapy updated. Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:1 Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antigen Presentation; Antimalarials; Chlorambucil; Contraindications; Cyclosporine; Cytokines; Dermatologic Agents; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Infliximab; Isoxazoles; Laser Therapy; Leflunomide; Male; Melatonin; Methotrexate; Models, Immunological; Pentoxifylline; Pregnancy; Pregnancy Complications; Sarcoidosis; Skin Diseases; Tetracyclines; Th1 Cells; Thalidomide	2007
Methotrexate embryopathy after therapy for misdiagnosed ectopic pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2007, Volume: 99, Issue:3 Topics: Abnormalities, Drug-Induced; Abortifacient Agents, Nonsteroidal; Adult; Congenital Abnormalities; Diagnostic Errors; Female; Fetal Diseases; Humans; Infant, Newborn; Methotrexate; Ovulation Induction; Pregnancy; Pregnancy, Ectopic	2007
Methotrexate in rheumatoid arthritis: can current knowledge and experience justify its use as a first-line disease-modifying agent? Postgraduate medical journal, 1993, Volume: 69, Issue:816 Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Adult; Aged; Arthritis, Rheumatoid; Bone Marrow; Digestive System; Female; Humans; Liver; Lung; Male; Methotrexate; Pregnancy	1993
Clinical teratology counseling and consultation case report: low dose methotrexate exposure in the early weeks of pregnancy. Teratology, 1993, Volume: 47, Issue:6 Topics: Abnormalities, Drug-Induced; Adult; Counseling; Female; Fetus; Gestational Age; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Methotrexate; Pregnancy; Teratogens	1993
Effects of immunosuppressive drugs during pregnancy. Arthritis and rheumatism, 1995, Volume: 38, Issue:12 Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animals; Azathioprine; Chlorambucil; Cyclophosphamide; Cyclosporine; Female; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Infertility, Female; Mercaptopurine; Methotrexate; Mice; Pregnancy; Pregnancy Complications; Rheumatic Diseases	1995
Developmental delay in fetal aminopterin/methotrexate syndrome. Teratology, 1999, Volume: 60, Issue:1 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Aminopterin; Child, Preschool; Developmental Disabilities; Face; Female; Folic Acid Antagonists; Growth Disorders; Humans; Intellectual Disability; Limb Deformities, Congenital; Male; Methotrexate; Pregnancy; Syndrome	1999
Low dose weekly methotrexate in early pregnancy. A case series and review of the literature. The Journal of rheumatology, 2000, Volume: 27, Issue:8 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Gestational Age; Humans; Maternal-Fetal Exchange; Methotrexate; Pregnancy; Pregnancy Outcome	2000
[Fetal aminopterin syndrome]. Ryoikibetsu shokogun shirizu, 2000, Issue:30 Pt 5 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aminopterin; Female; Fetal Diseases; Fetus; Folic Acid Antagonists; Humans; Infant, Newborn; Methotrexate; Pregnancy; Prenatal Exposure Delayed Effects; Prognosis; Syndrome	2000
Late side effects of treatment: skeletal, genetic, central nervous system, and oncogenic. Pediatric clinics of North America, 1976, Volume: 23, Issue:1 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antineoplastic Agents; Busulfan; Carcinogens; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Child; Female; Heart Diseases; Humans; Lung Diseases; Male; Menstruation Disturbances; Mercaptopurine; Methotrexate; Neoplasms; Neoplasms, Radiation-Induced; Pregnancy; Radiotherapy; Urinary Bladder Diseases	1976
Vitamin neurotoxicity. Molecular neurobiology, 1992,Spring, Volume: 6, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Avitaminosis; Blood-Brain Barrier; Carrier Proteins; Coenzymes; Drug Interactions; Folic Acid; Humans; Injections, Spinal; Liver; Methotrexate; Nervous System Diseases; Oxidation-Reduction; Pseudotumor Cerebri; Pyridoxine; Self Medication; Vitamin A; Vitamins	1992
[Methotrexate in dermatology: current aspects]. Annales de dermatologie et de venereologie, 1989, Volume: 116, Issue:2 Topics: Abnormalities, Drug-Induced; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Lung Diseases; Male; Methotrexate; Pregnancy; Skin Diseases	1989
Toxicity of low dose methotrexate in rheumatoid arthritis. The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12 Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infertility, Female; Infertility, Male; Kidney Diseases; Lung Diseases; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Random Allocation; Risk; Skin Diseases	1985
Methotrexate in the treatment of psoriasis. The Medical letter on drugs and therapeutics, 1972, Jun-09, Volume: 14, Issue:12 Topics: Abnormalities, Drug-Induced; Bone Marrow; Chemical and Drug Induced Liver Injury; Female; Hematologic Diseases; Humans; Kidney Diseases; Leucovorin; Liver; Methotrexate; Pregnancy; Psoriasis; Skin	1972
Some hazards of methotrexate treatment of psoriasis. Transactions of the St. John's Hospital Dermatological Society, 1970, Volume: 56, Issue:2 Topics: Abnormalities, Drug-Induced; Acute Kidney Injury; Brain; Child; Female; Humans; Immunosuppressive Agents; Kidney; Liver; Male; Methotrexate; Pregnancy; Psoriasis	1970
[Immunosuppressive agents]. Pharmaceutisch weekblad, 1971, Nov-05, Volume: 106, Issue:45 Topics: Abnormalities, Drug-Induced; Animals; Antigens; Antineoplastic Agents; Azathioprine; Chemical Phenomena; Chemistry; DNA; Drug Interactions; Female; Humans; Immunosuppressive Agents; Lethal Dose 50; Lymphocytes; Mercaptopurine; Methotrexate; Mice; Pregnancy; Rabbits; Rats; Transplantation Immunology	1971

Trials

1 trial(s) available for methotrexate and Abnormalities, Drug-Induced

Article	Year
Toxicity of low dose methotrexate in rheumatoid arthritis. The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12 Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infertility, Female; Infertility, Male; Kidney Diseases; Lung Diseases; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Random Allocation; Risk; Skin Diseases	1985

Article

Year

Toxicity of low dose methotrexate in rheumatoid arthritis.

The Journal of rheumatology. Supplement, 1985, Volume: 12 Suppl 12

Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infertility, Female; Infertility, Male; Kidney Diseases; Lung Diseases; Male; Methotrexate; Middle Aged; Neoplasms; Psoriasis; Random Allocation; Risk; Skin Diseases

1985

Other Studies

66 other study(ies) available for methotrexate and Abnormalities, Drug-Induced

Article	Year
Extremity Findings of Methotrexate Embryopathy. Hand (New York, N.Y.), 2020, Volume: 15, Issue:1 Topics: Abnormalities, Drug-Induced; Female; Fetal Diseases; Humans; Infant, Newborn; Maternal Exposure; Methotrexate; Pregnancy; Retrospective Studies; Upper Extremity; Upper Extremity Deformities, Congenital	2020
[Drugs news]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2015, Volume: 22, Issue:2 Topics: Abnormalities, Drug-Induced; Anti-Retroviral Agents; Azathioprine; Female; Humans; Infant, Newborn; Isotretinoin; Methotrexate; Pregnancy; Sumatriptan	2015
Weekly methotrexate: harmful to exposed embryos. Prescrire international, 2015, Volume: 24, Issue:159 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Antineoplastic Agents; Drug Administration Schedule; Embryo, Mammalian; Female; Folic Acid Antagonists; Gestational Age; Humans; Immunosuppressive Agents; Methotrexate; Patient Safety; Pregnancy; Risk Assessment; Risk Factors	2015
[Pregnancy outcome after preconceptional exposure to methotrexate for ectopic pregnancy]. Therapie, 2016, Volume: 71, Issue:4 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Female; Folic Acid Antagonists; Follow-Up Studies; Humans; Methotrexate; Off-Label Use; Polyglutamic Acid; Pregnancy; Pregnancy Outcome; Pregnancy, Ectopic; Prospective Studies; Young Adult	2016
Tocilizumab use in pregnancy: Analysis of a global safety database including data from clinical trials and post-marketing data. Seminars in arthritis and rheumatism, 2016, Volume: 46, Issue:2 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Databases, Factual; Drug Therapy, Combination; Female; Humans; Maternal Exposure; Methotrexate; Middle Aged; Pregnancy; Pregnancy Outcome; Product Surveillance, Postmarketing; Risk Assessment; Young Adult	2016
Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Annals of the rheumatic diseases, 2009, Volume: 68, Issue:7 Topics: Abnormalities, Drug-Induced; Administration, Oral; Antirheumatic Agents; Drug Therapy, Combination; Evidence-Based Medicine; Female; Folic Acid; Humans; Long-Term Care; Male; Methotrexate; Preconception Care; Rheumatic Diseases; Risk Factors	2009
High-dose methotrexate during pregnancy: risk of malformations. Prescrire international, 2010, Volume: 19, Issue:109 Topics: Abnormalities, Drug-Induced; Female; Folic Acid Antagonists; Humans; Methotrexate; Pregnancy; Pregnancy, Ectopic; Risk; Treatment Failure	2010
Methotrexate during the first trimester of pregnancy. Prescrire international, 2010, Volume: 19, Issue:109 Topics: Abnormalities, Drug-Induced; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Humans; Methotrexate; Pregnancy	2010
Congenital cardiac defects: a possible association of aminopterin syndrome and in utero methotrexate exposure? Pediatric cardiology, 2011, Volume: 32, Issue:4 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Angiography; Cardiac Surgical Procedures; Craniofacial Abnormalities; Diagnosis, Differential; Echocardiography; Female; Follow-Up Studies; Heart Defects, Congenital; Humans; Infant; Intellectual Disability; Lupus Erythematosus, Systemic; Male; Methotrexate; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects	2011
Congenitally corrected transposition of the great arteries in a patient with cor triatriatum: a rare combination. Pediatric cardiology, 2011, Volume: 32, Issue:4 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Angiography; Cardiac Catheterization; Cardiac Surgical Procedures; Cor Triatriatum; Craniofacial Abnormalities; Diagnosis, Differential; Echocardiography; Female; Humans; Immunosuppressive Agents; Infant; Intellectual Disability; Male; Methotrexate; Pregnancy; Prenatal Exposure Delayed Effects; Transposition of Great Vessels	2011
Methotrexate and misoprostol teratogenicity: further expansion of the clinical manifestations. American journal of medical genetics. Part A, 2011, Volume: 155A, Issue:7 Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Fatal Outcome; Humans; Infant; Infant, Newborn; Male; Methotrexate; Misoprostol; Phenotype; Teratogens	2011
Outcome following high-dose methotrexate in pregnancies misdiagnosed as ectopic. American journal of obstetrics and gynecology, 2011, Volume: 205, Issue:6 Topics: Abnormalities, Drug-Induced; Abortifacient Agents, Nonsteroidal; Abortion, Spontaneous; Adult; Diagnostic Errors; Dose-Response Relationship, Drug; Female; Humans; Methotrexate; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First; Pregnancy, Ectopic; Teratogens; Treatment Outcome	2011
Outcomes after anti-rheumatic drug use before and during pregnancy: a cohort study among 150,000 pregnant women and expectant fathers. Scandinavian journal of rheumatology, 2012, Volume: 41, Issue:3 Topics: Abnormalities, Drug-Induced; Adalimumab; Adolescent; Adult; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Cohort Studies; Databases, Factual; Drug Utilization Review; Etanercept; Fathers; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Mothers; Norway; Pregnancy; Pregnancy Outcome; Receptors, Tumor Necrosis Factor; Registries; Risk Factors; Young Adult	2012
Influence of the antifolate drug Methotrexate on the development of murine neural tube defects and genomic instability. Journal of applied toxicology : JAT, 2013, Volume: 33, Issue:9 Topics: Abnormalities, Drug-Induced; Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Diet; DNA Copy Number Variations; Dose-Response Relationship, Drug; Embryonic Development; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Genomic Instability; Male; Methotrexate; Mice; Mice, Inbred C57BL; Neural Tube; Neural Tube Defects; Pregnancy; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase	2013
In utero first trimester exposure to low-dose methotrexate with increased fetal nuchal translucency and associated malformations. Prenatal diagnosis, 2002, Volume: 22, Issue:6 Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Female; Folic Acid; Gestational Age; Heart Septal Defects; Hernia, Diaphragmatic; Humans; Methotrexate; Neck; Pregnancy; Pregnancy Complications; Ultrasonography, Prenatal	2002
Fetal methotrexate and misoprostol exposure: the past revisited. Teratology, 2002, Volume: 66, Issue:2 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortifacient Agents, Nonsteroidal; Abortion, Incomplete; Abortion, Induced; Adult; Female; Growth Disorders; Humans; Infant; Methotrexate; Misoprostol; Pregnancy	2002
Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma. Journal of pediatric hematology/oncology, 2003, Volume: 25, Issue:4 Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Follow-Up Studies; Humans; Ifosfamide; Incidence; Infant, Newborn; Italy; Male; Methotrexate; Middle Aged; Neoadjuvant Therapy; Oligospermia; Osteosarcoma; Puberty; Semen Preservation; Sperm Count; Surveys and Questionnaires	2003
Prenatal diagnosis of methotrexate embryopathy. Obstetrics and gynecology, 2003, Volume: 101, Issue:5 Pt 2 Topics: Abnormalities, Drug-Induced; Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Female; Humans; Methotrexate; Pregnancy; Treatment Failure; Ultrasonography, Prenatal	2003
Evaluation of Xenopus tropicalis as an alternative test organism for frog embryo teratogenesis assay--Xenopus (FETAX). Drug and chemical toxicology, 2003, Volume: 26, Issue:3 Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Embryo, Nonmammalian; Isoniazid; Methotrexate; Teratogens; Toxicity Tests; Xenopus; Xenopus laevis	2003
Cyclophosphamide, methotrexate, and cytarabine embropathy: is apoptosis the common pathway? Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:6 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Apoptosis; Cyclophosphamide; Cytarabine; Fatal Outcome; Female; Humans; Immunosuppressive Agents; Infant, Newborn; Methotrexate; Pregnancy; Pregnancy Trimester, First	2003
[COMMENTARIES ABOUT 107 CONGENITAL MALFORMATIONS]. La Semana medica, 1963, Oct-21, Volume: 123 Topics: Abnormalities, Drug-Induced; Aminopterin; Chromosome Aberrations; Chromosome Disorders; Congenital Abnormalities; Cortisone; Fetal Death; Hypoglycemic Agents; Infant, Newborn; Methotrexate; Thalidomide; Toxicology	1963
CHROMOSOME ABNORMALITY WITH LYMPHOID LEUKAEMIA. Lancet (London, England), 1964, May-09, Volume: 1, Issue:7341 Topics: Abnormalities, Drug-Induced; Busulfan; Child; Chromosome Aberrations; Chromosome Disorders; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Prednisolone; Toxicology	1964
Methotrexate embryopathy in a surviving intrauterine fetus after presumed diagnosis of ectopic pregnancy: case report. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2004, Volume: 26, Issue:11 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortifacient Agents, Nonsteroidal; Adult; Bone and Bones; Female; Genitalia, Male; Humans; Infant, Newborn; Male; Methotrexate; Pregnancy; Pregnancy Outcome; Pregnancy, Ectopic; Teratogens	2004
Low dose methotrexate in the first trimester of pregnancy: results of a French collaborative study. The Journal of rheumatology, 2004, Volume: 31, Issue:12 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Maternal-Fetal Exchange; Methotrexate; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Pregnancy Trimester, First; Prenatal Exposure Delayed Effects; Prospective Studies; Registries; Risk Assessment	2004
Methotrexate in pregnancy. Rheumatology (Oxford, England), 2005, Volume: 44, Issue:5 Topics: Abnormalities, Drug-Induced; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Infant, Newborn; Methotrexate; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects	2005
A case of methotrexate embryopathy with holoprosencephaly, expanding the phenotype. Birth defects research. Part A, Clinical and molecular teratology, 2006, Volume: 76, Issue:2 Topics: Abnormalities, Drug-Induced; Female; Holoprosencephaly; Humans; Infant; Methotrexate; Phenotype	2006
[Folic acid antagonist methotrexate causes the development malformation of heart and down-regulates the BMP2b and HAS2 expressions in zebrafish]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2007, Volume: 9, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Down-Regulation; Folic Acid Antagonists; Gene Expression Regulation; Glucuronosyltransferase; Heart Defects, Congenital; Hyaluronan Synthases; Methotrexate; Polymerase Chain Reaction; Zebrafish; Zebrafish Proteins	2007
Transgenic rescue of methotrexate-induced teratogenicity in Drosophila melanogaster. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 99, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Animals, Genetically Modified; Drosophila melanogaster; Female; Methotrexate; Tetrahydrofolate Dehydrogenase; Transgenes	2007
Exploring protection from methotrexate-induced teratogenicity in flies. Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 99, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Drosophila; Methotrexate; Tetrahydrofolate Dehydrogenase	2007
Methotrexate for psoriasis. Archives of dermatology, 1967, Volume: 95, Issue:1 Topics: Abnormalities, Drug-Induced; Chemical and Drug Induced Liver Injury; Female; Humans; Leukemia; Methotrexate; Peptic Ulcer; Pregnancy; Pregnancy Complications; Psoriasis	1967
Methotrexate. Clinics in rheumatic diseases, 1984, Volume: 10, Issue:2 Topics: Abnormalities, Drug-Induced; Arthritis; Arthritis, Rheumatoid; Drug Interactions; Humans; Infant, Newborn; Methotrexate; Myositis; Neoplasms; Psoriasis; Rheumatic Diseases	1984
Monitoring of organ formation in rat embryos after in vitro exposure to azathioprine, mercaptopurine, methotrexate or cyclosporin A. Toxicology, 1984, May-01, Volume: 31, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Azathioprine; Brain; Cyclosporins; Dose-Response Relationship, Drug; Female; Male; Mercaptopurine; Methotrexate; Organ Culture Techniques; Pregnancy; Rats; Rats, Inbred Strains	1984
Methotrexate and teratogenesis. Archives of dermatology, 1983, Volume: 119, Issue:11 Topics: Abnormalities, Drug-Induced; Female; Humans; Male; Methotrexate; Pregnancy; Spermatozoa	1983
Folate deficiency and in vitro palatogenesis I: effects of a folate-deficient culture on rabbit palate fusion and folate pools. Journal of craniofacial genetics and developmental biology, 1981, Volume: 1, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; DNA; Female; Folic Acid; Folic Acid Deficiency; In Vitro Techniques; Methotrexate; Palate; Pregnancy; Rabbits	1981
Methotrexate exposure prior to and during pregnancy. Teratology, 1994, Volume: 49, Issue:2 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Arthritis, Rheumatoid; Data Collection; Female; Fertilization; Folic Acid Antagonists; Humans; Infant, Newborn; Methotrexate; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Complications, Neoplastic; Pregnancy Outcome; Prospective Studies; Time Factors	1994
Methotrexate and misoprostol to terminate early pregnancy. The New England journal of medicine, 1996, Feb-08, Volume: 334, Issue:6 Topics: Abnormalities, Drug-Induced; Abortifacient Agents, Nonsteroidal; Abortion, Induced; Female; Humans; Methotrexate; Misoprostol; Pregnancy	1996
A risk assessment of topical tretinoin as a potential human developmental toxin based on animal and comparative human data. Journal of the American Academy of Dermatology, 1997, Volume: 36, Issue:3 Pt 2 Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Female; Humans; Isotretinoin; Keratolytic Agents; Methotrexate; Pregnancy; Risk Assessment; Teratogens; Thalidomide; Tretinoin; Valproic Acid	1997
Multiple congenital anomalies associated with weekly low-dose methotrexate treatment of the mother. Arthritis and rheumatism, 1997, Volume: 40, Issue:5 Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Juvenile; Bone and Bones; Female; Fetal Growth Retardation; Heart Murmurs; Humans; Maternal-Fetal Exchange; Methotrexate; Pregnancy	1997
Adult and two children with fetal methotrexate syndrome. Teratology, 1998, Volume: 57, Issue:2 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortifacient Agents; Adult; Aminopterin; Breast Neoplasms; Child; Child, Preschool; Craniofacial Abnormalities; Female; Fetal Diseases; Humans; Hypertelorism; Limb Deformities, Congenital; Male; Methotrexate; Pregnancy; Pregnancy Complications, Neoplastic; Syndrome; Teratogens	1998
Sex-specific differences in the treatment of severe psoriasis. Journal of the American Academy of Dermatology, 2000, Volume: 42, Issue:4 Topics: Abnormalities, Drug-Induced; Administration, Topical; Anti-Inflammatory Agents; Dermatologic Agents; Drug Utilization; Etretinate; Female; Glucocorticoids; Humans; Isotretinoin; Male; Methotrexate; Middle Aged; Psoriasis; PUVA Therapy; Sex Factors	2000
Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms. Cancer, 1976, Volume: 37, Issue:2 Suppl Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Chlorambucil; Drug Therapy, Combination; Female; Humans; Mechlorethamine; Methotrexate; Placenta Accreta; Pregnancy; Pregnancy Complications; Trophoblastic Neoplasms; Uterine Neoplasms; Vinblastine	1976
Reproductive performance of women successfully treated for gestational trophoblastic tumors. American journal of obstetrics and gynecology, 1976, Aug-15, Volume: 125, Issue:8 Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Azauridine; Child; Child, Preschool; Dactinomycin; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydatidiform Mole; Infant; Infant, Newborn; Leucovorin; Male; Mercaptopurine; Methotrexate; Pregnancy; Pregnancy Complications; Trophoblastic Neoplasms; Uterine Neoplasms	1976
The use of marmosets (Callithrix jacchus) in teratological and toxicological research. Primates in medicine, 1978, Volume: 10 Topics: Abnormalities, Drug-Induced; Animals; Callitrichinae; Disease Models, Animal; Female; Fetus; Haplorhini; Maternal-Fetal Exchange; Methotrexate; Pregnancy; Pregnancy, Animal; Research; Toxicology; Uterus	1978
Potentiation of methotrexate embryolethality by aspirin in rats. Teratology, 1978, Volume: 17, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Body Weight; Drug Synergism; Embryo, Mammalian; Female; Fetal Death; Methotrexate; Pregnancy; Rats; Tissue Distribution	1978
Aminopterin and methotrexate: folic acid deficiency. Teratology, 1978, Volume: 17, Issue:3 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortifacient Agents; Aminopterin; Female; Folic Acid Deficiency; Gestational Age; Humans; Methotrexate; Pregnancy	1978
Recognition in adult patients of malformations induced by folic-acid antagonists. Birth defects original article series, 1978, Volume: 14, Issue:6B Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Aminopterin; Female; Growth Disorders; Humans; Male; Methotrexate; Orofaciodigital Syndromes; Phenotype; Syndrome	1978
[Effect, on the fetus, of methotrexate (amethopterin) administered to the mother. Presentation of a case]. Revista do Hospital das Clinicas, 1978, Volume: 33, Issue:6 Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Maternal-Fetal Exchange; Methotrexate; Pregnancy	1978
Embryotoxicity of the folate antagonist methotrexate in rats and rabbits. Teratology, 1977, Volume: 15, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Fetal Resorption; Injections, Intraperitoneal; Injections, Intravenous; Methotrexate; Pregnancy; Rabbits; Rats; Species Specificity	1977
Drug-induced limb dysplasias in fetal rabbits. Teratology, 1977, Volume: 15, Issue:2 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Acetazolamide; Animals; Ectoderm; Extremities; Female; Hydroxyurea; Limb Deformities, Congenital; Litter Size; Maternal-Fetal Exchange; Mesoderm; Methotrexate; Pregnancy; Rabbits	1977
Teratogenicity studies with methotrexate, aminopterin, and acetylsalicylic acid in domestic cats. Teratology, 1976, Volume: 14, Issue:1 Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Aspirin; Cats; Female; Methotrexate; Teratogens; Time Factors	1976
[Immunologic tissue damage and immunosuppression]. Lakartidningen, 1976, Apr-21, Volume: 73, Issue:17 Topics: Abnormalities, Drug-Induced; Azathioprine; Cortisone; Cyclophosphamide; Female; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Infections; Infertility; Male; Mercaptopurine; Methotrexate; Neoplasms; T-Lymphocytes	1976
Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice. Teratogenesis, carcinogenesis, and mutagenesis, 1992, Volume: 12, Issue:5 Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Encephalocele; Female; Folic Acid; Methotrexate; Mice; Neural Tube Defects; Pregnancy; Valproic Acid	1992
Further validation of FETAX: evaluation of the developmental toxicity of five known mammalian teratogens and non-teratogens. Drug and chemical toxicology, 1990, Volume: 13, Issue:4 Topics: Abnormalities, Drug-Induced; Amaranth Dye; Animals; Aspartame; Azacitidine; Blastocyst; Drug Evaluation; Embryo, Nonmammalian; Ephedrine; Methotrexate; Teratogens; Xenopus laevis	1990
Amelioration by leucovorin of methotrexate developmental toxicity in rabbits. Teratology, 1991, Volume: 43, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Drug Interactions; Embryonic and Fetal Development; Endothelium, Vascular; Extracellular Space; Female; Leucovorin; Limb Deformities, Congenital; Mesoderm; Methotrexate; Pregnancy; Rabbits	1991
Pathogenesis of median facial clefts in mice treated with methotrexate. Teratology, 1987, Volume: 36, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Face; Female; Gestational Age; Methotrexate; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Pregnancy; Teratogens; Water-Electrolyte Balance	1987
Syndrome of multiple osseous deformities. Lancet (London, England), 1970, Nov-07, Volume: 2, Issue:7680 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Aminopterin; Bone and Bones; Female; Folic Acid Antagonists; Humans; Maternal-Fetal Exchange; Methotrexate; Pregnancy	1970
Transplacental chemical carcinogenesis in man. Journal of the National Cancer Institute, 1971, Volume: 47, Issue:6 Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Chloramphenicol; Diethylstilbestrol; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Maternal-Fetal Exchange; Methotrexate; Mice; Neoplasms; Neoplasms, Muscle Tissue; Phenytoin; Pregnancy; Uterine Cervical Neoplasms; Vaginal Neoplasms	1971
Teratogenicity from drugs--an increasing problem. Disease-a-month : DM, 1974 Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Amniocentesis; Animals; Anti-Bacterial Agents; Azathioprine; Azauridine; Busulfan; Chlorambucil; Colchicine; Contraceptives, Oral; Cyclophosphamide; Diethylstilbestrol; Ethanol; Female; Fetus; Genotype; Humans; Iodine Radioisotopes; Mercaptopurine; Methotrexate; Mice; Nitrogen Mustard Compounds; Phenotype; Pregnancy; Pregnancy, Animal; Prenatal Diagnosis; Radiation Genetics; Rats; Species Specificity; Thalidomide; Tranquilizing Agents	1974
Evaluation of the toxicity and teratogenecity of drugs. Polish journal of pharmacology and pharmacy, 1973, Volume: 25, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Barbiturates; Chick Embryo; Gestational Age; Insulin; Methotrexate; Phenobarbital; Tolbutamide; Toxicology	1973
Post-methotrexate babies. The Ceylon medical journal, 1973, Volume: 18, Issue:2 Topics: Abnormalities, Drug-Induced; Adult; Female; Gestational Age; Humans; Hydatidiform Mole; Maternal-Fetal Exchange; Methotrexate; Pregnancy; Time Factors	1973
Teratogenicity of methotrexate in mice. Teratology, 1974, Volume: 9, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetus; Gestational Age; Intestines; Maternal-Fetal Exchange; Methotrexate; Mice; Mice, Inbred ICR; Neomycin; Pregnancy; Species Specificity	1974
Teratologists united. Nature, 1971, May-14, Volume: 231, Issue:5298 Topics: Abnormalities, Drug-Induced; Animals; Central Nervous System; Congenital Abnormalities; Genetics, Medical; Haplorhini; Humans; Methotrexate; Rats; Societies, Scientific; Thalidomide; Wales; Water Supply	1971
Methotrexate in young women with psoriasis. The New England journal of medicine, 1971, Jul-29, Volume: 285, Issue:5 Topics: Abnormalities, Drug-Induced; Adult; Female; Fetus; Humans; Infant, Newborn; Methotrexate; Pregnancy; Psoriasis	1971
Methotrexate-induced congenital malformations. The Medical journal of Australia, 1971, Nov-20, Volume: 2, Issue:21 Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Methotrexate; Pregnancy; Pregnancy Complications, Infectious; Psoriasis; Skull	1971
Transient inhibition of DNA synthesis by methotrexate, in the rat embryo and foetus. Journal of embryology and experimental morphology, 1971, Volume: 26, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; DNA; Embryo, Mammalian; Female; Fetus; Gestational Age; Leucovorin; Methotrexate; Pregnancy; Rats; Time Factors	1971
Methotrexate-induced congenital malformations. The Journal of pediatrics, 1968, Volume: 72, Issue:6 Topics: Abnormalities, Drug-Induced; Abortion, Criminal; Adult; Aminopterin; Child, Preschool; Female; Humans; Infant, Newborn; Methotrexate; Pregnancy; Skull	1968