methotrexate has been researched along with Abnormalities, Autosome in 162 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 102 (62.96) | 18.7374 |
| 1990's | 35 (21.60) | 18.2507 |
| 2000's | 16 (9.88) | 29.6817 |
| 2010's | 7 (4.32) | 24.3611 |
| 2020's | 2 (1.23) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, X; Fu, S; Ji, G; Liu, P; Liu, Y; Ma, J; Meng, X; Qu, Y; Song, T; Sun, W; Wang, X; Xing, R; Xing, S; Zhang, H; Zhou, J; Zhu, J | 1 |
| Alzoubi, KH; Hussein, SA; Khabour, OF; Rababa'h, AM | 1 |
| Al Achkar, W; Aljapawe, A; As'sad, M; Liehr, T; Wafa, A | 1 |
| Cai, M; Chen, F; Cui, X; Fu, S; Gao, W; Guan, R; Han, Y; Hou, L; Li, C; Lv, Y; Ma, J; Meng, X; Song, Y; Wang, P; Wang, X; Zhang, H | 1 |
| Dabrowska, M; Rode, W; Skoneczny, M; Uram, L | 1 |
| Li, Y; Mi, Y; Qiu, L; Wang, J; Zhao, Y; Zou, D | 1 |
| Charalampidou, S; Chatzimeletiou, K; Goulis, DG; Kantartzi, P; Oikonomou, L; Panidis, D; Papadimas, I; Sioga, A; Tarlatzis, BC; Zournatzi, V | 1 |
| Abd El-Rahim, AH; Alam, SS; Hafiz, NA | 1 |
| Amano, K; Itoyama, S; Kameda, H; Kizaki, M; Mori, S; Nagasawa, H; Nemoto, T; Sagawa, M; Takeuchi, T; Tamaru, J; Tokuhira, M; Tomikawa, T; Watanabe, R | 1 |
| Hajifathali, A; Movafagh, A; Zamani, M | 1 |
| Carrara, HH; Silva, LM; Takahashi, CS | 1 |
| Dent, P; Fisher, PB; Gopalkrishnan, RV; Narayan, G; Su, ZZ | 1 |
| MITANI, M; REISMAN, LE; ZUELZER, WW | 1 |
| RODRIGUEZDEAGNESE, LR; YANZON, NA | 1 |
| CHITHAM, RG; MCIVER, EJ | 1 |
| BRANDKAMP, WW; MOORE, JG; VANCAMPENHOUT, JL | 1 |
| FREI, E; FREIREICH, EJ | 1 |
| REISMAN, LE; THOMPSON, RI; ZUELZER, WW | 1 |
| MARSDEN, HB; STEWARD, JK | 1 |
| Canale Cama, G; Cella, L; d'Alesio, V; Durante, M; Gialanella, G; Grossi, G; Pacelli, R; Pugliese, M; Punzo, G; Salvatore, M; Sardi, I; Scampoli, P; Solla, R | 1 |
| Deng, XY; Dong, S; Fu, SB; Guo, LQ; Li, P; Yan, YD; Zeng, L; Zhang, GY; Zhang, Y | 1 |
| Benini, S; Castellani, GC; Hattinger, CM; Manara, MC; Pasello, M; Picci, P; Remondini, D; Reverter-Branchat, G; Scotlandi, K; Serra, M | 1 |
| Goldschmidt, N; Gural, A; Kornberg, A; Paltiel, O; Shopen, A; Spectre, G | 1 |
| Azma, RZ; Cheong, SK; Leong, CF; Salwati, S; Sharifah, NA | 1 |
| Deng, X; Dong, S; Fu, S; Xu, Z; Yan, Y; Zhang, L; Zhang, Y | 1 |
| Jensen, MK | 1 |
| Fennell, SJ; Gorst, DW; Harrison, PV; Higgins, GS | 1 |
| Haren, JM; Kaneko, Y; Larson, RA; Rowley, JD; Variakojis, D | 1 |
| Kałuzewski, B | 1 |
| Beckman, DA; Brent, RL | 1 |
| Barclay, BJ; Haynes, RH; Kunz, BA; Little, JG | 1 |
| Barbi, G; Steinbach, P; Vogel, W | 1 |
| Bostock, CJ; Tyler-Smith, C | 2 |
| Beverley, SM; Brown, PC; Schimke, RT | 1 |
| Cassileth, PA | 1 |
| Kubota, K; Mizoguchi, H; Nomura, Y; Okada, M | 1 |
| Inhorn, SL; Meisner, LF; Sargent, LM; Wiley, JE | 1 |
| Korhonen, T; Lahtinen, R; Puolakka, K | 1 |
| Gallo, JH; Misawa, S; Testa, JR | 1 |
| Delinassios, JG; Talieri, MJ | 2 |
| Märki, U; Osterhoff, DR | 1 |
| Gács, G; Kardos, G; Koós, R; Polcz, A; Révész, T; Schuler, D | 1 |
| Giorgi, R; Mondello, C; Nuzzo, F | 1 |
| Chessells, JM | 1 |
| Bostock, CJ; Clark, EM | 1 |
| Bogáthy, B; Koós, R; Schuler, D; Szakmáry, E; Szollár, J | 1 |
| Cowell, JK | 1 |
| Attardi, G; Gay, H; Keeley, B; Masters, J | 1 |
| Yunis, JJ | 2 |
| Donaldson, CH; Gates, AH; Levy, MD | 1 |
| Brown, PC; Kaufman, RJ; Schimke, RT | 1 |
| Natarajan, AT; Slijepcevic, P | 1 |
| Leonard, NJ; Martin, RH; Rademaker, AW | 1 |
| Bhattacharjee, SB; Bhattacharyya, NP; Dey, SK; Ghosh, R; Roy, M; Sengupta, S | 1 |
| Hahn, PJ | 1 |
| Labella, T; Larizza, L; Orlando, S; Riva, P | 1 |
| Amylon, MD; Chao, NJ; Long, GD; Nademanee, AP; Negrin, RS; O'Donnell, MR; Parker, PM; Smith, EP; Snyder, DS; Stein, AS | 1 |
| Daubner, D; Lõrincz, I; Pályi, I; Péter, I; Vincze, B | 1 |
| Beck, WT; Danks, MK; Hill, AB; Thompson, FH; Trent, JM | 1 |
| Antonopoulou, E; Lyberatou, E; Polymilis, C; Velissariou, V | 1 |
| Littlefield, LG; Peterson, PT; Richardson, VB; Sayer, AM | 1 |
| Harrod, MJ; Menter, MA; Morris, LF; Silverman, AK | 1 |
| Friberg, LG; Granberg, S; Islam, MQ; Köpf, I; Levan, A; Levan, G | 1 |
| Akatsuka, J; Furukawa, T; Nakazawa, S; Nishimura, K; Ohira, M; Okawa, Y; Sugita, K; Tsuchida, M | 1 |
| Kavallaris, M; Pittman, SM; Stewart, BW | 1 |
| Fahrig, R; Steinkamp-Zucht, A | 1 |
| Bhargava, MK; Udayakumar, AM | 1 |
| Dursun, N; Erenmemişoğlu, A; Ozkul, Y; Saatçi, C; Süer, C | 1 |
| Jeevanram, RK; Paul, SF; Venkatachalam, P | 1 |
| Amylon, M; Buck, S; Camitta, B; Ekizian, R; Matherly, LH; Pullen, J; Ravindranath, Y; Simpson, PM; Taub, JW; Williamson, M; Wong, SC | 1 |
| Keshava, C; Keshava, N; Nath, J; Ong, TM; Whong, WZ | 1 |
| Armstrong, MJ; Bradt, CI; Galloway, SM; Greenwood, SK; Hill, RB; Hilliard, CA; Johnson, TE | 1 |
| Hahn, PJ; Rizwana, R | 1 |
| Foureman, P; Hahn, PJ; Winfield, JA | 1 |
| Aricò, M; Basso, G; Biondi, A; Conter, V; De Rossi, G; Di Tullio, MT; Lo Nigro, L; Masera, G; Messina, C; Miniero, R; Mori, PG; Pession, A; Rizzari, C; Rondelli, R; Santoro, N; Silvestri, D; Tamaro, P; Testi, A; Valsecchi, MG | 1 |
| Blom, J; Kaplan, SS; Rybka, WB; Shekhter-Levin, S | 1 |
| Friedman, CL; Hamlin, JL; Mesner, LD; Singer, MJ; Trask, BJ | 1 |
| Duesberg, P; Hehlmann, R; Stindl, R | 1 |
| Eden, O; Gibson, B; Hann, I; Harrison, C; Harrison, G; Hill, F; Richards, S; Vora, A | 1 |
| Aboul-Ella, AA; Gabr, HM; Ismail, MM; Moustafa, HA; Saleh, AM; Shahin, AA | 1 |
| Adachi, S; Akiyama, Y; Hamahata, K; Kubota, M; Lin, YW; Nakahata, T; Watanabe, K | 1 |
| Bailey, CC; Chessells, JM; Gibson, BE; Hann, IM; Harrison, G; Hill, FG; Richards, SM | 1 |
| Agbalika, F; Boulanger, E; Daniel, MT; Grollet, L; Maarek, O; Molina, JM; Oksenhendler, E; Sigaux, F | 1 |
| Sutherland, GR | 1 |
| Maier, P; Schmid, W | 1 |
| Colyer, SP; Dufrain, RJ; Littlefield, LG; Sayer, AM | 1 |
| Finley, WH | 1 |
| Tanneberger, S | 1 |
| Bostock, CJ; Clark, EM; Harding, NG; Mounts, PM; Tyler-Smith, C; van Heyningen, V; Walker, PM | 1 |
| Jensen, MK; Nyfors, A | 1 |
| Ajdarić, B; Garzicić, B; Korać, D; Stojimirović, E | 1 |
| Albrecht, AM; Biedler, JL; Spengler, BA | 1 |
| Biedler, JL; Spengler, BA | 1 |
| Choi, GH; Hole, H; Spahlinger, B | 1 |
| Iakovleva, TK; Moiseenko, VM; Monakhov, AS | 1 |
| Hirabayashi, K; Kasahara, Y; Makita, T; Miura, D; Nakai, Y; Yagi, K | 1 |
| Akabutu, J; Carroll, AJ; Esseltine, DW; Lauer, SJ; Look, AT; Mahoney, D; Payment, C; Shuster, JJ; Vuchich, MJ; Whitehead, VM | 1 |
| Abella, E; Alvarado, CS; Chauvenet, A; Dubowy, R; Harris, M; Inoue, S; Krischer, JP; Ravindranath, Y; Ritchey, AK; Wiley, J | 1 |
| Abe, T; Furukawa, T; Kishi, K; Maekawa, T; Nagura, E; Narita, M; Saito, H; Shibata, A | 1 |
| Hahn, PJ; Longo, JA; Nevaldine, B | 1 |
| Horie, H; Kinugawa, N; Kudoh, F; Miyamoto, S; Okimoto, Y; Oto, S | 1 |
| Bonetti, F; Borgato, L; Capelli, P; Chilosi, M; Fiore-Donati, L; Hirohashi, S; Menestrina, F; Pizzolo, G; Scarpa, A; Zamboni, G | 1 |
| Badía, L; Beneyto, M; Martínez-Castellano, F; Montero, MR; Palau, F; Prieto, F | 1 |
| Capizzi, RL | 1 |
| Fujimoto, S; Fujinaga, K; Fujino, T; Kato, H; Sakai, K; Wake, N; Yasuda, T | 1 |
| Hustinx, TW; Scheres, JM; Smeets, DF | 1 |
| Hansen, HH; Hansen, M; Osterlind, K; Pedersen, AG; Pedersen-Bjergaard, J; Philip, P | 1 |
| Li, GR | 1 |
| Caporossi, D; Dallapiccola, B; Nicoletti, B; Porfirio, B; Tedeschi, B; Vernole, P | 1 |
| Barbi, G; Djalali, M; Steinbach, P | 1 |
| Schimke, RT; Schumacher, RI; Sherwood, SW | 1 |
| Vítek, JA | 1 |
| Secker-Walker, LM; Stewart, EL | 1 |
| Koziorowska, J; Pieńkowska, K | 1 |
| Schimke, RT | 1 |
| Hahn, P; Kapp, LN; Morgan, WF; Painter, RB | 1 |
| Barnes, IC; Maltby, EL | 1 |
| Sakai, K | 1 |
| Holland, JF; Kamen, BA; Lo, RJ; Ohnoshi, T; Ohnuma, T; Scanlon, KJ; Wolman, SR | 1 |
| Ayusawa, D; Hori, T; Koyama, H; Seno, T; Shimizu, K; Takeishi, K | 1 |
| Hill, A; Johnston, RN; Schimke, RT | 1 |
| Hill, AB; Schimke, RT | 1 |
| Cohen, MA; Gerbie, AB; Nadler, HL | 1 |
| Bäumer, A; Diekmann, L; Pfeiffer, RA; Rickers, H | 1 |
| Andreesu, M; Matefsu, C; Mogos, I; Mudric, V | 1 |
| Korsak, E | 1 |
| Frei, E; Freireich, EJ; Oppenheim, JJ; Tjio, JH; Whang-Peng, J | 1 |
| Andreassi, L; Ottolenghi, F | 1 |
| Chiarenza, A; Lazzaro, C; Randazzo, SD | 1 |
| Bennett, JM; Carbone, PP; Foley, HT | 1 |
| Büttner, HH; Junge, WD; Kyank, H; Pelz, L | 1 |
| Hutchison, DJ | 1 |
| Craddock, CG; Crandall, BF; Hinkes, E; Weber, F | 1 |
| Catovsky, D; Costello, C; Galton, DA; Goldman, JM; Spiers, AD | 1 |
| Hoffbrand, AV; Tripp, E | 1 |
| Blatt, PM; Cathey, WJ; Miller, HL; Rothstein, G | 1 |
| Hansmann, I; Röhrborn, G; Vogel, F | 1 |
| Michalowski, A; Steffen, J | 1 |
| Jasińska, JK; Steffen, JA; Swierkowska, KM | 1 |
| Hansmann, I | 2 |
| Hansmann, I; Röhrborn, G | 1 |
| Albrecht, AM; Biedler, JL; Hutchison, DJ; Spengler, BA | 1 |
| Arroyo Nombela, JJ; Rodriguez Murcia, C | 1 |
| Duffy, DM; Melnyk, J; Sparkes, RS | 1 |
| Kwaan, HC; Long, DL; Pierre, RV | 1 |
| Burgess, MA; Gibson, OM; Stanley, LG | 1 |
| Bauke, J; Cremer, HJ; Heimpel, H | 1 |
| Pochedly, C | 1 |
| Tessmann, K | 1 |
| De Luca, M; Rossi, A; Ventruto, V | 1 |
| Beurey, J; Gilgenkrantz, S; Grandidier, M; Weber, M | 1 |
| Kawasaki, M; Sugahara, T | 1 |
| Hutchison, DJ; Kurita, S; Sirotnak, FM | 1 |
| Kaung, DT; Swartzendruber, AA | 1 |
| Chakrabarti, SG; Harrell, ER; Janzen, MK; Voorhees, JJ | 1 |
| Boddington, MM; Ryan, TJ; Spriggs, AI | 1 |
| Zuelzer, WW | 1 |
13 review(s) available for methotrexate and Abnormalities, Autosome
| Article | Year |
|---|---|
Mechanisms of teratogenesis.
Topics: Aminopterin; Androgens; Animals; Antithyroid Agents; Chromosome Aberrations; Coumarins; Diethylstilbestrol; Embryo, Mammalian; Ethanol; Female; Fetus; Humans; Methotrexate; Methylmercury Compounds; Mutagens; Nucleic Acids; Oxazoles; Phenytoin; Polychlorinated Biphenyls; Pregnancy; Progestins; Teratogens; Tetracycline; Thalidomide; Thyroid Hormones | 1984 |
Adult acute nonlymphocytic leukemia.
Topics: Acute Disease; Adult; Aged; Antigens, Neoplasm; Antigens, Surface; Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Cytarabine; Daunorubicin; Humans; Leukemia; Meningeal Neoplasms; Methotrexate; Middle Aged; Thioguanine | 1984 |
Acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Asparaginase; B-Lymphocytes; Bacterial Infections; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Infant; Leukemia; Leukemia, Lymphoid; Leukocyte Count; Male; Meningeal Neoplasms; Mercaptopurine; Methotrexate; Prednisolone; T-Lymphocytes; Testicular Neoplasms; Vincristine | 1982 |
Molecular biology of double-minute chromosomes.
Topics: Animals; Cell Cycle; CHO Cells; Chromatin; Chromosome Aberrations; Chromosomes; Cricetinae; DNA Damage; DNA, Circular; DNA, Neoplasm; Drug Resistance; Extrachromosomal Inheritance; Gene Amplification; Humans; Methotrexate; Models, Genetic; Neoplasms; Staining and Labeling; Tetrahydrofolate Dehydrogenase | 1993 |
Methotrexate and reproduction in men: case report and recommendations.
Topics: Adult; Arthritis; Chromosome Aberrations; Chromosome Disorders; Genetic Counseling; Humans; Male; Methotrexate; Mutation; Psoriasis; Spermatogenesis | 1993 |
A clinical, molecular and cytogenetic study of 12 cases of human herpesvirus 8 associated primary effusion lymphoma in HIV-infected patients.
Topics: Adult; Anti-HIV Agents; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bleomycin; Chromosome Aberrations; Cidofovir; Cyclophosphamide; Cytosine; Doxorubicin; Drug Therapy, Combination; Etoposide; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Immunophenotyping; Interferon-alpha; Karyotyping; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Lymphoma, Large-Cell, Immunoblastic; Male; Methotrexate; Middle Aged; Organophosphonates; Organophosphorus Compounds; Polymerase Chain Reaction; Prednisone; Prognosis; Remission Induction; Survival Analysis; Vincristine; Vindesine; Viral Load | 2001 |
Individual cell biology: basis and prospects for a rational cancer chemotherapy.
Topics: Adenocarcinoma; Brain Neoplasms; Breast Neoplasms; Cell Cycle; Chromosome Aberrations; Cyclophosphamide; Dactinomycin; DNA, Neoplasm; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Fructose-Bisphosphate Aldolase; Humans; Isoenzymes; Kinetics; Male; Methotrexate; Neoplasm Staging; Neoplasms; Prognosis | 1977 |
[Importance of cytogenetics in the study of acute non-lymphoblastic leukemias].
Topics: Bone Marrow Examination; Chromosome Aberrations; Chromosome Deletion; Chromosome Inversion; Chromosomes, Human; Humans; Leukemia, Myeloid, Acute; Methotrexate; Myelodysplastic Syndromes; Neoplasms, Multiple Primary; Proto-Oncogenes; Translocation, Genetic | 1991 |
Leukemia: experimental and preclinical studies.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Cell Line; Chromosome Aberrations; Cytarabine; Drug Resistance; Humans; Leukemia; Methotrexate; Prognosis | 1990 |
Methotrexate resistance and gene amplification. Mechanisms and implications.
Topics: Animals; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosome Fragility; DNA Replication; Drug Resistance; Gene Amplification; Humans; Methotrexate; Neoplasms; Tetrahydrofolate Dehydrogenase | 1986 |
Thymineless death and genetic events in mammalian cells.
Topics: Animals; Cell Survival; Centrifugation, Density Gradient; Chromosome Aberrations; Cycloheximide; Dactinomycin; DNA; DNA Replication; Humans; Interphase; Methotrexate; Methyltransferases; Mice; Mitosis; Mutation; Recombination, Genetic; Sister Chromatid Exchange; Thymidine; Thymidine Monophosphate; Thymidylate Synthase; Ultrafiltration | 1985 |
Antifolate resistance and the genetic control of dihydrofolate reductase activity.
Topics: Animals; Chromosome Aberrations; DNA Replication; DNA, Bacterial; Drug Resistance; Drug Resistance, Microbial; Enterococcus faecalis; Leukemia L1210; Methotrexate; Mice; Microbial Sensitivity Tests; Mutation; Nucleic Acid Hybridization; Phenotype; Protein Binding; Radiation Effects; Streptococcus pneumoniae; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1971 |
[Mutagenicity testing of chemical compounds].
Topics: Abortion, Spontaneous; Animals; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Drug Evaluation; Female; Germ Cells; Humans; Hydrazines; Infant, Newborn; Isoniazid; Lymphocytes; Male; Methods; Methotrexate; Mice; Mutagens; Mutation; Nitrosamines; Pregnancy; Rats; Spermatogenesis; Teratogens; Triaziquone | 1974 |
3 trial(s) available for methotrexate and Abnormalities, Autosome
| Article | Year |
|---|---|
Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Cause of Death; Child; Chromosome Aberrations; Chromosome Disorders; Cyclosporine; Cytogenetics; Drug Therapy, Combination; Etoposide; Female; Graft vs Host Disease; Humans; Immunosuppression Therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Methylprednisolone; Middle Aged; Recurrence; Survival Rate; Whole-Body Irradiation | 1994 |
Intensive BFM chemotherapy for childhood ALL: interim analysis of the AIEOP-ALL 91 study. Associazione Italiana Ematologia Oncologia Pediatrica.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Child, Preschool; Chromosome Aberrations; Combined Modality Therapy; Cranial Irradiation; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Disease-Free Survival; Doxorubicin; Female; Humans; Infant; Italy; Leucovorin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Remission Induction; Risk; Thioguanine; Treatment Outcome; Vincristine | 1998 |
Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocol.
Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Etoposide; Female; Humans; Infant; Leukocyte Count; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Risk Factors; Sex Factors; Thioguanine; United Kingdom; Vincristine | 2001 |
146 other study(ies) available for methotrexate and Abnormalities, Autosome
| Article | Year |
|---|---|
Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate‑resistant human colorectal cancer cells.
Topics: Chromosome Aberrations; Colorectal Neoplasms; DNA; DNA Repair; DNA-Binding Proteins; Humans; Methotrexate; MutS Homolog 3 Protein | 2023 |
The Protective Effect of Cilostazol in Genotoxicity Induced by Methotrexate in Human Cultured Lymphocytes.
Topics: Adolescent; Adult; Cell Death; Cells, Cultured; Chromosome Aberrations; Cilostazol; Humans; Kinetics; Lymphocytes; Male; Methotrexate; Mutagens; Protective Agents; Sister Chromatid Exchange; Young Adult | 2020 |
Childhood pre-B cell acute lymphoblastic leukemia with translocation t(1;19)(q21.1;p13.3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report.
Topics: Adolescent; Antimetabolites, Antineoplastic; Chromosome Aberrations; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 16; Doxorubicin; Fatal Outcome; Health Services Accessibility; Humans; Immunophenotyping; Male; Methotrexate; Oncogene Proteins, Fusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Syria; Translocation, Genetic; Vincristine | 2017 |
Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate-resistant colon cancer cells.
Topics: Cell Cycle; Cell Line, Tumor; Cell Nucleus; Chromosome Aberrations; Chromosomes; Colonic Neoplasms; DNA Breaks, Double-Stranded; Drug Resistance, Neoplasm; Gene Amplification; Homologous Recombination; HT29 Cells; Humans; Methotrexate | 2019 |
Methotrexate-induced senescence of human colon cancer cells depends on p53 acetylation, but not genomic aberrations.
Topics: Acetylation; Antimetabolites, Antineoplastic; Cellular Senescence; Chromosome Aberrations; Colonic Neoplasms; Genomics; Humans; Methotrexate; Signal Transduction; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2019 |
Additional chromosomal abnormalities and their prognostic significance in adult Philadelphia-positive acute lymphoblastic leukemia: with or without imatinib in chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamides; Chromosome Aberrations; Cyclophosphamide; Cytarabine; Daunorubicin; Disease-Free Survival; Etoposide; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Kaplan-Meier Estimate; Male; Mercaptopurine; Methotrexate; Middle Aged; Mitoxantrone; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Pyrimidines; Salvage Therapy; Vincristine; Vindesine; Young Adult | 2009 |
Semen analysis by electron and fluorescence microscopy in a case of partial hydatidiform mole reveals a high incidence of abnormal morphology, diploidy, and tetraploidy.
Topics: Abortifacient Agents, Nonsteroidal; Abortion, Induced; Adult; Chromosome Aberrations; DNA Fragmentation; Female; Genetic Predisposition to Disease; Humans; Hydatidiform Mole; In Situ Hybridization, Fluorescence; In Situ Nick-End Labeling; Male; Methotrexate; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Ploidies; Pregnancy; Semen Analysis; Sperm Count; Sperm Motility; Spermatozoa; Ultrasonography; Uterine Neoplasms | 2011 |
Protective role of taurine against genotoxic damage in mice treated with methotrexate and tamoxfine.
Topics: Androgens; Animals; Antimetabolites, Antineoplastic; Antimutagenic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Bone Marrow Cells; Chromosome Aberrations; DNA Damage; DNA Fragmentation; Electrophoresis, Agar Gel; Germ Cells; Glutathione; Liver; Male; Methotrexate; Mice; Sperm Motility; Spermatocytes; Sulfhydryl Compounds; Tamoxifen; Taurine | 2011 |
Clinicopathological analyses in patients with other iatrogenic immunodeficiency-associated lymphoproliferative diseases and rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD20; Antirheumatic Agents; Arthritis, Rheumatoid; Chromosome Aberrations; Epstein-Barr Virus Infections; Female; Flow Cytometry; Humans; Immunocompromised Host; Immunohistochemistry; Karyotype; Ki-1 Antigen; Lymphoproliferative Disorders; Male; Methotrexate; Middle Aged; Prognosis; Survival Analysis | 2012 |
Secondary chromosomal abnormalities of de novo acute myeloid leukemia--a first report from the Middle East.
Topics: Bone Marrow Cells; Cell Cycle; Chromosome Aberrations; Chromosome Banding; Female; Humans; Iran; Karyotyping; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle East; Tumor Cells, Cultured | 2011 |
Study of chromosome damage in patients with breast cancer treated by two antineoplastic treatments.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Cell Division; Chromosome Aberrations; Chromosomes, Human; Cyclophosphamide; DNA Damage; Drug Administration Schedule; Epirubicin; Female; Fluorouracil; Humans; Methotrexate; Middle Aged; Mitotic Index; Sister Chromatid Exchange | 2002 |
Progression elevated gene-3, PEG-3, induces genomic instability in rodent and human tumor cells.
Topics: Animals; Antigens, Differentiation; Antimetabolites, Antineoplastic; Carcinoma; Cell Cycle Proteins; Cell Division; Cells, Cultured; Chromosome Aberrations; Drug Resistance, Neoplasm; Embryo, Mammalian; Female; Fibroblasts; Gene Amplification; Genome; Humans; Male; Methotrexate; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms; Prostatic Neoplasms; Protein Phosphatase 1; Proto-Oncogene Proteins; Rats; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Uterine Cervical Neoplasms | 2002 |
CHROMOSOME STUDIES IN LEUKEMIA. I. EVIDENCE FOR THE ORIGIN OF LEUKEMIC STEM LINES FROM ANEUPLOID MUTANTS.
Topics: Aneuploidy; Bone Marrow Examination; Child; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Microscopy, Electron, Scanning Transmission; Neoplasms; Pathology; Prednisone | 1964 |
[COMMENTARIES ABOUT 107 CONGENITAL MALFORMATIONS].
Topics: Abnormalities, Drug-Induced; Aminopterin; Chromosome Aberrations; Chromosome Disorders; Congenital Abnormalities; Cortisone; Fetal Death; Hypoglycemic Agents; Infant, Newborn; Methotrexate; Thalidomide; Toxicology | 1963 |
CHROMOSOME ABNORMALITY WITH LYMPHOID LEUKAEMIA.
Topics: Abnormalities, Drug-Induced; Busulfan; Child; Chromosome Aberrations; Chromosome Disorders; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Prednisolone; Toxicology | 1964 |
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; Chromosomes, Human; Endometriosis; Female; Fluorouracil; Geriatrics; Humans; Leukocytes; Melanoma; Methotrexate; Neoplasms; Nitrogen Mustard Compounds; Ovarian Neoplasms; Sarcoma; Thiotepa; Uterine Cervical Neoplasms; Uterine Neoplasms; Vinblastine | 1964 |
LEUKEMIA.
Topics: Antineoplastic Agents; Blood Transfusion; Bone Marrow Transplantation; Child; Chromosome Aberrations; Humans; Infections; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Methotrexate; Mortality; Neoplasms; Oncogenic Viruses; Research | 1964 |
FURTHER OBSERVATION ON THE ROLE OF ANEUPLOIDY IN ACUTE LEUKEMIA.
Topics: Adolescent; Aneuploidy; Antineoplastic Agents; Bone Marrow Cells; Child; Chromosome Aberrations; Chromosome Disorders; Cyclophosphamide; Genetics, Medical; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Research; Vincristine | 1964 |
LEUKAEMIA IN CHILDREN.
Topics: Adolescent; Black People; Bone Marrow Examination; Busulfan; Child; Chromosome Aberrations; Cyclophosphamide; Drug Therapy; Genetics, Medical; Humans; Infant; Leukemia; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Mortality; Pathology; Psychotherapy; Social Conditions; Statistics as Topic; Steroids; United Kingdom; Vincristine; Virus Diseases; White People | 1965 |
Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Chromosome Aberrations; Cisplatin; Female; Fluorouracil; Humans; Lymph Node Excision; Lymph Nodes; Lymphocytes; Mastectomy, Segmental; Methotrexate | 2003 |
[Application of atomic force microscopy in the study of morphology of double minute chromosomes].
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Chromosome Aberrations; Chromosomes; Chromosomes, Mammalian; Dose-Response Relationship, Drug; Methotrexate; Mice; Microscopy, Atomic Force | 2003 |
Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques.
Topics: Antineoplastic Agents; Bone Neoplasms; Chromosome Aberrations; Chromosomes, Human; Drug Resistance, Neoplasm; Humans; Karyotyping; Membrane Transport Proteins; Methotrexate; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Osteosarcoma; Ploidies; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 2003 |
Prolonged fever of unknown origin and hemophagocytosis evolving into acute lymphoblastic leukemia.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Cytarabine; Disease Progression; Doxorubicin; Fever of Unknown Origin; Histiocytosis, Non-Langerhans-Cell; Humans; Karyotyping; Male; Methotrexate; Middle Aged; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Rituximab; Splenomegaly; Vincristine | 2004 |
Complex karyotypic abnormalities in a case of acute myeloid leukaemia--M4Eo.
Topics: Adult; Antimetabolites, Antineoplastic; China; Chromosome Aberrations; Cytarabine; Fatal Outcome; Humans; Injections, Spinal; Karyotyping; Leukemia, Myelomonocytic, Acute; Male; Methotrexate | 2005 |
Double minute chromosomes in mouse methotrexate-resistant cells studied by atomic force microscopy.
Topics: Animals; Chromosome Aberrations; Drug Resistance; Gene Amplification; Humans; Methotrexate; Mice; Microscopy, Atomic Force; Tumor Cells, Cultured | 2006 |
Chromosome studies in patients treated with azathioprine and amethopterin.
Topics: Adult; Autoimmune Diseases; Azathioprine; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosome Disorders; Female; Humans; Lymphocytes; Male; Methotrexate; Middle Aged | 1967 |
Methotrexate, psoriasis, and malignancy.
Topics: Adult; Aged; Bone Marrow; Chromosome Aberrations; Female; Humans; Leukemia; Male; Methotrexate; Middle Aged; Psoriasis | 1984 |
Nonrandom chromosome abnormalities in angioimmunoblastic lymphadenopathy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chromosome Aberrations; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Therapy, Combination; Female; Herpes Zoster; Humans; Immunoblastic Lymphadenopathy; Karyotyping; Leucovorin; Lymph Nodes; Lymphoma; Male; Methotrexate; Middle Aged; Prednisone; Procarbazine; Vinblastine; Vincristine | 1982 |
BrdU-Hoechst-Giemsa analysis of DNA replication in synchronized lymphocyte cultures. Study of human X and Y chromosomes.
Topics: Bromodeoxyuridine; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosome Banding; DNA Replication; Female; Humans; Kinetics; Lymphocyte Activation; Lymphocytes; Male; Methotrexate; Mitotic Index; Sex Chromosomes; Sister Chromatid Exchange; Staining and Labeling; X Chromosome; Y Chromosome | 1982 |
Genetic and biochemical consequences of thymidylate stress.
Topics: Chromosome Aberrations; DNA Repair; DNA, Fungal; DNA, Mitochondrial; Ethyl Methanesulfonate; Floxuridine; Methotrexate; Methylnitronitrosoguanidine; Models, Biological; Mutation; Recombination, Genetic; Saccharomyces cerevisiae; Sister Chromatid Exchange; Sulfanilamides; Thymidine Monophosphate; Thymine Nucleotides | 1982 |
Nonrandom distribution of methotrexate-induced aberrations on human chromosomes. Detection of further folic acid sensitive fragile sites.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Floxuridine; Folic Acid Deficiency; Humans; Karyotyping; Lymphocytes; Methotrexate | 1984 |
Gene amplification in methotrexate-resistant mouse cells. II. Rearrangement and amplification of non-dihydrofolate reductase gene sequences accompany chromosomal changes.
Topics: Animals; Cell Line; Chromosome Aberrations; DNA; DNA Restriction Enzymes; Drug Resistance; Gene Amplification; Karyotyping; Lymphoma; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; T-Lymphocytes | 1981 |
Gene amplification in methotrexate-resistant mouse cells. III. Interrelationships between chromosome changes and DNA sequence amplification or loss.
Topics: Animals; Cell Line; Chromosome Aberrations; DNA; DNA Restriction Enzymes; Drug Resistance; Gene Amplification; Leukemia, Experimental; Lymphoma; Methotrexate; Mice; T-Lymphocytes; Tetrahydrofolate Dehydrogenase | 1981 |
Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.
Topics: Animals; Cell Line; Chromosome Aberrations; Deoxyribonuclease EcoRI; DNA Restriction Enzymes; Drug Resistance; Extrachromosomal Inheritance; Fibroblasts; Flow Cytometry; Gene Amplification; Karyotyping; Methotrexate; Mice; Mice, Inbred Strains; Tetrahydrofolate Dehydrogenase | 1981 |
Quantitative analysis of chromosomal G-bands in human hematopoietic disorders by methotrexate synchronization technique.
Topics: Anemia; Bone Marrow; Cell Cycle; Chromosome Aberrations; Chromosome Banding; Chromosome Disorders; Cytarabine; Hematologic Diseases; Humans; Karyotyping; Kinetics; Leukemia; Metaphase; Methotrexate | 1984 |
Comparison of prometaphase chromosome techniques with emphasis on the role of colcemid.
Topics: Chromosome Aberrations; Chromosome Banding; Dactinomycin; Demecolcine; Ethidium; Female; Humans; Male; Methotrexate; Mitotic Index; Prophase | 1984 |
Diabetes insipidus in preleukaemic phase of acute myeloid leukaemia in 2 patients with empty sella turcica. A report of 2 cases.
Topics: Anemia, Aplastic; Chromosome Aberrations; Diabetes Insipidus; Empty Sella Syndrome; Female; Humans; Injections, Spinal; Leukemia, Myeloid, Acute; Male; Methotrexate; Middle Aged; Pituitary Gland; Preleukemia; Sella Turcica; Tomography, X-Ray Computed | 1984 |
Centromere spreading in acute nonlymphocytic leukemia.
Topics: Aged; Bone Marrow; Cells, Cultured; Centromere; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Humans; Karyotyping; Leukemia, Myeloid, Acute; Male; Methotrexate | 1984 |
Increased dihydrofolate reductase, double minutes and increased nucleolar activation in methotrexate-resistant HeLa cells.
Topics: Chromosome Aberrations; Drug Resistance; Gene Amplification; HeLa Cells; Humans; Methotrexate; Nucleolus Organizer Region; Tetrahydrofolate Dehydrogenase | 1983 |
Horse lymphocyte cell synchronization: improved technique for chromosome analysis.
Topics: Animals; Cell Cycle; Chromosome Aberrations; Chromosome Banding; DNA Replication; Horses; Karyotyping; Lymphocytes; Methotrexate | 1983 |
Late effects of therapy in children previously treated for leukaemia or malignant tumour.
Topics: Adolescent; Brain; Child; Child, Preschool; Chromosome Aberrations; Female; Humans; Infant; Infertility; Injections, Spinal; Intelligence Tests; Leukemia; Male; Methotrexate; Neoplasms, Multiple Primary; Pituitary Hormones; Radiotherapy | 1983 |
Chromosomal effects of methotrexate on cultured human lymphocytes.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug; Female; Humans; Lymphocytes; Methotrexate; Mitosis | 1984 |
Gene amplification in methotrexate-resistant mouse cells. V. Intact amplified units can be transferred to and amplified in methotrexate-sensitive mouse L cells.
Topics: Adenine Phosphoribosyltransferase; Animals; Chromosome Aberrations; Chromosome Disorders; DNA; Drug Resistance; Gene Amplification; L Cells; Methotrexate; Mice; Mutation; Nucleic Acid Hybridization; Thymidine Kinase; Transfection | 1983 |
The investigation of late cytogenetic effects in children with acute leukaemia in long remission and off all chemotherapy.
Topics: Child; Child, Preschool; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human; Crossing Over, Genetic; Female; Follow-Up Studies; Humans; Infant; Karyotyping; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Methotrexate; Sister Chromatid Exchange | 1981 |
Appearance of double minute chromosomes in somatic cell hybridisation experiments involving the HAT selection system.
Topics: Aminopterin; Animals; Cell Fusion; Cell Separation; Chromosome Aberrations; Gene Amplification; Humans; Hybrid Cells; Karyotyping; Methotrexate; Mice; Selection, Genetic; Tetrahydrofolate Dehydrogenase | 1982 |
Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines.
Topics: Chromosome Aberrations; Clone Cells; Drug Resistance; Gene Amplification; Genes; HeLa Cells; Humans; Karyotyping; Methotrexate; Phenotype; Selection, Genetic; Tetrahydrofolate Dehydrogenase | 1982 |
New chromosome techniques in the study of human neoplasia.
Topics: Adolescent; Adult; Agar; Bone Marrow; Bone Marrow Cells; Cell Line; Chromosome Aberrations; Chromosome Banding; Female; Humans; Leukemia; Lymph Nodes; Lymphocytes; Male; Metaphase; Methotrexate; Neoplasms; Tissue Extracts | 1981 |
Oocyte aneuploidy screening using superovulating prepubertal mice: effect of methotrexate.
Topics: Aneuploidy; Animals; Chromosome Aberrations; Female; Genetic Testing; Methotrexate; Mice; Oocytes; Ovulation; Ovum; Superovulation | 1981 |
Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines.
Topics: Animals; Cell Line; Chromosome Aberrations; Clone Cells; DNA; Drug Resistance; Extrachromosomal Inheritance; Flow Cytometry; Gene Amplification; Methotrexate; Mice; Nucleic Acid Hybridization; Sarcoma 180; Tetrahydrofolate Dehydrogenase | 1981 |
Fragile site at Xq21 in Chinese hamster and its implications for the in vitro chromosomal aberration test.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Line; CHO Cells; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mapping; Cricetinae; Cricetulus; Fibroblasts; Folic Acid Antagonists; Methotrexate; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; X Chromosome | 1995 |
Analysis of chromosomal abnormalities in human sperm after chemotherapy by karyotyping and fluorescence in situ hybridization (FISH).
Topics: Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chromosome Aberrations; Cyclophosphamide; Doxorubicin; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Leucovorin; Lymphoma; Male; Methotrexate; Prednisone; Spermatozoa; Vincristine | 1995 |
Characterisation of methotrexate-resistant clones.
Topics: Animals; Cell Division; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Drug Resistance; Male; Methotrexate; Mutation; Sister Chromatid Exchange; Tetrahydrofolate Dehydrogenase; Transfection | 1993 |
Satellite DNA sequences flank amplified DHFR domains in marker chromosomes of mouse fibrosarcoma cells.
Topics: Animals; Chromosome Aberrations; DNA, Neoplasm; DNA, Satellite; Drug Resistance; Fibrosarcoma; Fluorescent Antibody Technique; Gene Amplification; Genes; In Situ Hybridization; In Situ Hybridization, Fluorescence; Methotrexate; Mice; Neoplasm Proteins; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1994 |
Establishment, characterization and drug sensitivity of a new anaplastic thyroid carcinoma cell line (BHT-101).
Topics: Animals; Carcinoma; Cell Division; Cell Line; Chromosome Aberrations; Doxorubicin; Epithelium; Female; Fibroblasts; Humans; Immunohistochemistry; Karyotyping; Lymphatic Metastasis; Methotrexate; Mice; Mice, Inbred CBA; Middle Aged; Neoplasm Transplantation; Ploidies; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thyroid Neoplasms; Tumor Cells, Cultured | 1993 |
Loss of tumorigenicity in a methotrexate-resistant human leukemia cell line.
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Drug Resistance; Folic Acid; Genes; Humans; Karyotyping; Leukemia, T-Cell; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Tetrahydrofolate Dehydrogenase; Translocation, Genetic; Tumor Cells, Cultured | 1993 |
Chromosome breakage in individuals with single-cell structural aberrations and habitual abortions.
Topics: Abortion, Habitual; Analysis of Variance; Cells, Cultured; Chromosome Aberrations; DNA; DNA Damage; Female; Humans; Lymphocytes; Male; Methotrexate; Pregnancy | 1993 |
Cell-cycle-stage specificity of the methotrexate block as resolved by X-ray-induced chromosome damage.
Topics: Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosomes; Humans; Lymphocytes; Methotrexate | 1994 |
Cytogenetic findings in 111 ovarian cancer patients: therapy-related chromosome aberrations and heterochromatic variants.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Chromosome Aberrations; Chromosome Deletion; Chromosome Inversion; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 9; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Follow-Up Studies; Heterochromatin; Humans; Karyotyping; Melphalan; Methotrexate; Middle Aged; Mitomycins; Neoplasms, Second Primary; Ovarian Neoplasms; Radiotherapy; Translocation, Genetic; Vincristine | 1993 |
High frequency of etoposide (VP-16)-related secondary leukemia in children with non-Hodgkin's lymphoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparagine; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human, Pair 11; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Follow-Up Studies; Humans; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Life Tables; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Neoplasms, Second Primary; Risk; Vincristine | 1993 |
Karyotypic analysis of CCRF-CEM and drug-resistant cell lines with stable and unstable ploidy.
Topics: Chromosome Aberrations; Chromosomes, Human, Pair 8; Drug Resistance; Gene Deletion; Humans; Karyotyping; Leukemia, T-Cell; Methotrexate; Ploidies; Polyploidy; Tumor Cells, Cultured; Vincristine | 1993 |
Monitoring of induced chromosomal aberrations in S. cerevisiae in agarose gels by pulsed field gel electrophoresis.
Topics: 4-Nitroquinoline-1-oxide; Chromosome Aberrations; DNA, Fungal; Electrophoresis, Gel, Pulsed-Field; Methotrexate; Mutagens; Saccharomyces cerevisiae; Thioguanine | 1995 |
Persistence of chromosomal aberrations in blood lymphocytes 11 years after cessation of CMF therapy in a breast cancer patient.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromosome Aberrations; Cisplatin; Female; Fluorouracil; Humans; Karyotyping; Lymphocytes; Methotrexate; Middle Aged; Time Factors | 1996 |
Effect of zinc deficiency on chromosomal abnormalities in mice.
Topics: Animals; Body Weight; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosome Disorders; Diet; Diploidy; Feeding Behavior; Female; Male; Methotrexate; Mice; Mitotic Index; Zinc | 1996 |
A comparative study of synchronised and conventional culture methods on the micronucleus dose-response curve.
Topics: Cell Culture Techniques; Chromosome Aberrations; Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Humans; Methotrexate; Micronucleus Tests; Mitotic Index; Mutagens | 1997 |
Increased frequency of expression of elevated dihydrofolate reductase in T-cell versus B-precursor acute lymphoblastic leukemia in children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blast Crisis; Burkitt Lymphoma; Carrier Proteins; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Leukocyte Count; Male; Methotrexate; Neoplasm Proteins; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Tetrahydrofolate Dehydrogenase | 1997 |
Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells.
Topics: Animals; Antimutagenic Agents; Cell Line; Chromosome Aberrations; Cricetinae; Leucovorin; Male; Methotrexate; Mitotic Index; Mutagens; Rats; Rats, Sprague-Dawley | 1998 |
Fewer chromosome aberrations and earlier apoptosis induced by DNA synthesis inhibitors, a topoisomerase II inhibitor or alkylating agents in human cells with normal compared with mutant p53.
Topics: Alkylating Agents; Antineoplastic Agents; Aphidicolin; Apoptosis; B-Lymphocytes; Cell Division; Cell Line; Chromosome Aberrations; Cytarabine; DNA Replication; Etoposide; Humans; Hydroxyurea; Methotrexate; Mutagenesis; Nucleic Acid Synthesis Inhibitors; Radiation, Ionizing; Topoisomerase II Inhibitors; Tumor Suppressor Protein p53 | 1998 |
CpG islands and double-minute chromosomes.
Topics: Animals; Cell Line; Chromosome Aberrations; CpG Islands; DNA Methylation; Gene Amplification; Methotrexate; Mice; MutS Homolog 3 Protein; Promoter Regions, Genetic; Proteins; Restriction Mapping; Tetrahydrofolate Dehydrogenase | 1998 |
Chromosome breakpoints near CpG islands in double minutes.
Topics: Animals; Cell Line; Chromosome Aberrations; CpG Islands; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Probes; Drug Resistance; Gene Amplification; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1998 |
Tetraploidy in acute myeloid leukemia secondary to large cell lymphoma.
Topics: Acute Disease; Aged; Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Chromosome Aberrations; Combined Modality Therapy; Cyclophosphamide; Fatal Outcome; Humans; Immunophenotyping; Karyotyping; Leukemia, Myeloid; Leukemia, Radiation-Induced; Lymphoma, Large B-Cell, Diffuse; Male; Mercaptopurine; Methotrexate; Neoplasms, Second Primary; Neoplastic Stem Cells; Palliative Care; Polyploidy; Prednisone; Procarbazine; Recurrence; Vincristine | 1998 |
Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks.
Topics: Chromosome Aberrations; Chromosome Deletion; Chromosome Painting; Chromosomes, Human; Chromosomes, Human, Pair 5; DNA Damage; Drug Resistance; Gene Amplification; HeLa Cells; Humans; In Situ Hybridization, Fluorescence; Methotrexate; Tetrahydrofolate Dehydrogenase | 2000 |
Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy.
Topics: Aneuploidy; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Cell Size; CHO Cells; Chromosome Aberrations; Cricetinae; Cytarabine; Demecolcine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Male; Methotrexate; Mice; Mutation; Puromycin; Tumor Cells, Cultured | 2000 |
Protective effect of folinic acid on low-dose methotrexate genotoxicity.
Topics: Adult; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Chromosome Aberrations; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Injections, Intramuscular; Injections, Intraperitoneal; Leucovorin; Male; Methotrexate; Micronucleus Tests; Middle Aged; Rats; Rats, Wistar | 2001 |
Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnormalities after allogeneic bone marrow transplantation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Clone Cells; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Daunorubicin; DNA Damage; Female; Follow-Up Studies; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Mercaptopurine; Methotrexate; Methylprednisolone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Remission Induction; Time Factors; Transplantation Conditioning; Transplantation, Homologous; Vincristine | 2001 |
Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment.
Topics: Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Clinical Trials as Topic; Cytogenetic Analysis; Disease-Free Survival; Down Syndrome; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Infant; Male; Methotrexate; Patient Selection; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Survival Rate | 2001 |
Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Culture Media; Dose-Response Relationship, Drug; Folic Acid; Humans; Hydrogen-Ion Concentration; Lymphocytes; Methotrexate; Phenotype; Thymidine; Time Factors | 1979 |
Ten model mutagens evaluated by the micronucleus test.
Topics: Animals; Bleomycin; Bone Marrow; Bone Marrow Cells; Cell Line; Cell Nucleus; Chromosome Aberrations; Cyclophosphamide; Cytarabine; Demecolcine; Dose-Response Relationship, Drug; Doxorubicin; Erythroblasts; Fluorouracil; Genetic Techniques; Mercaptopurine; Methotrexate; Mice; Mutagens; Thiotepa; Vincristine | 1976 |
Sister-chromatid exchanges in human lymphocytes exposed during Go to four classes of DNA-damaging chemicals.
Topics: Bleomycin; Cell Cycle; Chlorambucil; Chromatids; Chromosome Aberrations; Cytarabine; DNA; Humans; Lymphocytes; Methotrexate; Mitomycins; Mutagens; Thiotepa | 1979 |
Effect of drugs on chromosome structure.
Topics: Carcinogens; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Contraceptives, Oral; DNA; Down Syndrome; Female; Humans; Karyotyping; Leukocytes; Lysergic Acid Diethylamide; Methotrexate; Mitosis; Mutagens; Nutrition Disorders; Polyploidy; RNA; Teratogens; Trisomy | 1975 |
The development of resistance to methotrexate in a mouse melanoma cell line. I. Characterisation of the dihydrofolate reductases and chromosomes in sensitive and resistant cells.
Topics: Animals; Cell Line; Chromosome Aberrations; DNA, Neoplasm; Drug Resistance; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; Tetrahydrofolate Dehydrogenase | 1979 |
Cytogenetic effects of methotrexate on human cells in vivo: comparison between results obtained by chromosome studies on bone-marrow cells and blood lymphocytes and by the micronucleus test.
Topics: Bone Marrow; Cell Nucleus; Chromosome Aberrations; Chromosomes; Humans; Lymphocytes; Methotrexate; Mutagens; Myositis; Psoriasis | 1979 |
[Chemotherapy and mutagenesis. A study of chromosome aberrations as a test for mutagenesis after the use of cyclophosphamide, methotrexate and cytosine arabinoside].
Topics: Child; Chromosome Aberrations; Cyclophosphamide; Cytarabine; Humans; Lymphocytes; Methotrexate; Mutagenicity Tests | 1979 |
Biochemical and karyological properties of cells resistant to the quinazoline antifolate, methasquin.
Topics: Aspartic Acid; Cell Line; Cell Survival; Chromosome Aberrations; Drug Resistance; Glycine Hydroxymethyltransferase; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Tetrahydrofolate Dehydrogenase | 1978 |
Metaphase chromosome anomaly: association with drug resistance and cell-specific products.
Topics: Aspartic Acid; Cell Line; Chromosome Aberrations; Chromosomes; DNA Replication; Drug Resistance; Methotrexate; Neuroblastoma; Tetrahydrofolate Dehydrogenase | 1976 |
[Effects of Methotrexat on the chromosomes of a human fetus in vivo (author's transl)].
Topics: Abortion, Therapeutic; Blood Cells; Brain; Chromatids; Chromosome Aberrations; Chromosomes; Cytogenetics; Female; Fetus; Hodgkin Disease; Humans; Lung; Methotrexate; Mitosis; Polyploidy; Pregnancy; Pregnancy Complications; Skin | 1975 |
High resolution of human chromosomes.
Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes; Chromosomes, Human, 4-5; Demecolcine; Humans; Karyotyping; Lymphocytes; Methotrexate; Mitosis | 1976 |
[Chromosomal restructurings and the distribution of chromosome fragile sites in the peripheral blood lymphocytes in a breast cancer patient after cytostatic therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Combined Modality Therapy; Female; Fluorouracil; Humans; Lymphocytes; Methotrexate; Middle Aged; Ring Chromosomes; Tamoxifen; Time Factors | 1992 |
Mechanism of induction of micronuclei and chromosome aberrations in mouse bone marrow by multiple treatments of methotrexate.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromatography, High Pressure Liquid; Chromosome Aberrations; Folic Acid Antagonists; Kinetics; Male; Methotrexate; Mice; Micronucleus Tests; Mutagens; Tetrahydrofolate Dehydrogenase | 1992 |
Accumulation of high levels of methotrexate polyglutamates in lymphoblasts from children with hyperdiploid (greater than 50 chromosomes) B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group study.
Topics: Child; Child, Preschool; Chromosome Aberrations; Diploidy; Female; Humans; Infant; Lymphocytes; Male; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; S Phase | 1992 |
Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498.
Topics: Acute Disease; Adolescent; Adult; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Azacitidine; Child; Chromosome Aberrations; Chromosome Disorders; Cytarabine; Daunorubicin; Down Syndrome; Etoposide; Female; Follow-Up Studies; Humans; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Prednisone; Remission Induction; Thioguanine; Vincristine | 1992 |
A new myeloblastic leukemia cell line with double minute chromosomes. Induction of methotrexate resistance and dihydrofolate reductase gene amplification.
Topics: Chromosome Aberrations; Cloning, Molecular; Drug Resistance; Gene Amplification; Genes, myc; Humans; Leukemia, Myeloid, Acute; Male; Methotrexate; Nucleic Acid Hybridization; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1992 |
Molecular structure and evolution of double-minute chromosomes in methotrexate-resistant cultured mouse cells.
Topics: Adaptation, Biological; Animals; Biological Evolution; Cells, Cultured; Chromosome Aberrations; Chromosomes; Deoxyribonucleases, Type II Site-Specific; Drug Resistance; Gene Amplification; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase | 1992 |
Treatment for B-cell-type lymphoma in a girl associated with Bloom's syndrome.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bloom Syndrome; Child; Chromosome Aberrations; Cyclophosphamide; Doxorubicin; Etoposide; Female; Genetic Predisposition to Disease; Humans; Hydrocortisone; Lymphoma, B-Cell; Methotrexate; Pharyngeal Neoplasms; Prednisolone; Prognosis; Remission Induction | 1992 |
Evidence of c-myc gene abnormalities in mediastinal large B-cell lymphoma of young adult age.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chromosome Aberrations; Chromosome Disorders; Combined Modality Therapy; Cyclophosphamide; DNA Probes; DNA, Neoplasm; Doxorubicin; Female; Gene Rearrangement; Genes, myc; Humans; Leucovorin; Lymphoma, B-Cell; Male; Mediastinal Neoplasms; Methotrexate; Nucleic Acid Hybridization; Prednisone; Proto-Oncogenes; Restriction Mapping; Vincristine | 1991 |
Methotrexate-resistant mechanisms in human choriocarcinoma cells.
Topics: Blotting, Southern; Choriocarcinoma; Chromosome Aberrations; Drug Resistance; Female; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured; Uterine Neoplasms | 1989 |
The most common fragile site in man is 3p14.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, 1-3; Female; Floxuridine; Humans; Infant; Karyotyping; Male; Methotrexate; Middle Aged; Pedigree | 1986 |
Acute nonlymphocytic leukemia, preleukemia, and solid tumors following intensive chemotherapy of small cell carcinoma of the lung.
Topics: Acute Disease; Carcinoma, Small Cell; Chromosome Aberrations; Chromosome Disorders; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Etoposide; Female; Humans; Leukemia; Lomustine; Lung Neoplasms; Male; Methotrexate; Preleukemia; Risk; Vincristine | 1985 |
[Chromosomal studies in patients with trophoblastic diseases before and after chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Chromosomes, Human, 1-3; Female; Fluorouracil; Humans; Methotrexate; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms | 1986 |
Common fragile sites: their prevalence in subjects with constitutional and acquired chromosomal instability.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aphidicolin; Cells, Cultured; Chromosome Aberrations; Chromosome Disorders; Chromosome Fragile Sites; Chromosome Fragility; Diterpenes; Fanconi Anemia; Female; Heterozygote; Humans; Italy; Lymphocytes; Male; Methotrexate; Middle Aged; Ovarian Neoplasms | 1987 |
Folic acid sensitive fragile sites are not limited to the human karyotype. Demonstration of nonrandom gaps and breaks in the Persian vole Ellobius lutescens Th. inducible by methotrexate, fluorodeoxyuridine, and aphidicolin.
Topics: Animals; Aphidicolin; Arvicolinae; Chromosome Aberrations; Chromosome Fragile Sites; Chromosome Fragility; Diterpenes; Female; Floxuridine; Folic Acid; Humans; Karyotyping; Male; Methotrexate; Species Specificity | 1985 |
Effect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Cycloheximide; DNA Replication; Drug Resistance; Female; Hydroxyurea; Methotrexate; Ovary | 1988 |
Similarity in dynamics of single or double minute chromosomes incidence and number of chromosomal aberrations during long-term treatment of a human cell line with methotrexate.
Topics: Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosomes; Drug Resistance; Gene Amplification; Humans; Melanoma; Methotrexate | 1987 |
Detection of the chromosomally abnormal clone in acute lymphoblastic leukemia.
Topics: Bone Marrow; Child; Child, Preschool; Chromosome Aberrations; Clone Cells; Humans; Karyotyping; Leukemia, Lymphoid; Lymphocytes; Methotrexate; Ploidies | 1986 |
[Effect of folinic acid (leucovorin) on cytotoxic and cytogenetic effects of methotrexate].
Topics: Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; Erythrocytes; Hematopoietic Stem Cells; Leucovorin; Methotrexate; Mice; Mutagens | 1986 |
Chromosomal aberrations in early stages of development of methotrexate resistance in HeLa cells.
Topics: Chromosome Aberrations; Drug Resistance; HeLa Cells; Humans; Methotrexate | 1987 |
Chromosomal changes without DNA overproduction in hydroxyurea-treated mammalian cells: implications for gene amplification.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Chromosome Aberrations; Chromosomes; Colchicine; Cricetinae; Cricetulus; DNA Replication; Gene Amplification; Hydroxyurea; Methotrexate | 1986 |
Prometaphase chromosome analysis as a routine diagnostic technique.
Topics: Chromosome Aberrations; Chromosome Banding; Humans; Metaphase; Methotrexate | 1986 |
[Mechanisms of development of resistance to methotrexate in choriocarcinoma cells].
Topics: Cells, Cultured; Choriocarcinoma; Chromosome Aberrations; Drug Resistance; Female; Gene Amplification; Humans; Methotrexate; Pregnancy; Tetrahydrofolate Dehydrogenase; Uterine Neoplasms | 1986 |
Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro.
Topics: Cell Line; Cell Survival; Chromosome Aberrations; Drug Resistance; Humans; Leukemia, Lymphoid; Methotrexate; Tetrahydrofolate Dehydrogenase | 1985 |
Fifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneity.
Topics: Animals; Cells, Cultured; Chromosome Aberrations; DNA; DNA Replication; Drug Resistance; Gene Amplification; Humans; Hydroxyurea; Methotrexate; Mice; Neoplasms; Tetrahydrofolate Dehydrogenase | 1985 |
Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations.
Topics: Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; DNA; DNA Replication; Drug Resistance; Flow Cytometry; Gene Amplification; Hydroxyurea; Lymphoma; Methotrexate; Mice; Sister Chromatid Exchange; Tetrahydrofolate Dehydrogenase | 1985 |
Chromosomal investigation in pregnancies following chemotherapy for choriocarcinoma.
Topics: Choriocarcinoma; Chromosome Aberrations; Chromosomes; Dactinomycin; Female; Humans; Methotrexate; Pregnancy; Uterine Neoplasms | 1971 |
[Morphologic, immunocytologic and cytogenetic studies on a child with erythroleukemia].
Topics: Blood Cell Count; Bone Marrow Examination; Child, Preschool; Chromosome Aberrations; Coombs Test; Cytoplasmic Granules; DNA; Enzymes; gamma-Globulins; Hepatomegaly; Humans; Karyotyping; Leukemia, Erythroblastic, Acute; Leukocytes; Male; Methotrexate; Mosaicism; Neutrophils; Osmotic Fragility; Phagocytosis; Splenomegaly | 1969 |
[Chromosomal studies in correlation with other biologic constants in neoplasms treated by chemotherapy].
Topics: Adult; Antibody Formation; Bone Marrow; Cell Division; Chromosome Aberrations; Female; Fluorouracil; Humans; Immunity, Cellular; Male; Melphalan; Methotrexate; Middle Aged; Mitosis; Neoplasms; Thiotepa | 1974 |
[In vitro effects of vinblastine sulfate, methotrexate and alkeran on human chromosomes].
Topics: Chromosome Aberrations; Chromosomes; Humans; Melphalan; Methotrexate; Mutation; Sulfates; Time Factors; Vinblastine | 1974 |
Cytogenetic studies in 45 patients with acute lymphocytic leukemia.
Topics: Adolescent; Adult; Aneuploidy; Blood Cells; Bone Marrow Cells; Bone Marrow Examination; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Down Syndrome; Female; Humans; Infant; Karyotyping; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine | 1969 |
[Limitations and risks of therapy of psoriasis with amethopterin and hydroxyurea].
Topics: Adult; Aged; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chromosome Aberrations; Chromosome Disorders; Drug Eruptions; Female; Gastrointestinal Diseases; Hematopoietic System; Humans; Hydroxyurea; Male; Methotrexate; Middle Aged; Psoriasis; Pyelonephritis | 1971 |
[Damage due to treatment of psoriasis with folic acid antagonists].
Topics: Anemia, Hypochromic; Chemical and Drug Induced Liver Injury; Chromosome Aberrations; Chromosome Disorders; Drug Eruptions; Folic Acid Antagonists; Headache; Humans; Leucovorin; Methotrexate; Mouth Diseases; Mouth Mucosa; Nausea; Psoriasis; Vertigo | 1972 |
Combination chemotherapy in accelerated phase of chronic granulocytic leukemia.
Topics: Adolescent; Adult; Aged; Anemia; Blood Platelets; Blood Transfusion; Blood Urea Nitrogen; Bone Marrow Cells; Bone Marrow Examination; Chromosome Aberrations; Cytomegalovirus; Female; Fever; Hemorrhage; Humans; Jaundice; Leukemia, Myeloid; Leukocyte Count; Leukocytes; Leukopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Nocardia Infections; Pneumonia; Prednisone; Proteus Infections; Pseudomonas Infections; Sepsis; Thrombocytopenia; Vincristine | 1969 |
[Pregnancies following methotrexate treatmnet. Chromosome analysis in mother and child].
Topics: Chromosome Aberrations; Female; Humans; Infant; Karyotyping; Maternal-Fetal Exchange; Methotrexate; Pregnancy; Pregnancy Complications; Trophoblastic Neoplasms | 1973 |
Acute leukemia with C-G chromosome translocation.
Topics: Adult; Bone Marrow Examination; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Chromosomes, Human, 6-12 and X; Humans; Injections, Spinal; Karyotyping; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Pedigree; Prednisone; Quinacrine; Skin; Vincristine | 1973 |
Chronic granulocytic leukaemia: multiple-drug chemotherapy for acute transformation.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Asparaginase; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia, Myeloid; Male; Methotrexate; Middle Aged; Prednisolone; Thioguanine; Vincristine | 1974 |
Unbalanced deoxyribonucleotide synthesis caused by methotrexate.
Topics: Adenosine Triphosphate; Chromosome Aberrations; Chromosome Disorders; Deoxyadenosines; Deoxyribonucleotides; DNA; Erythrocytes; Folic Acid Deficiency; Humans; Ligases; Lymphocyte Activation; Lymphocytes; Methotrexate; Polynucleotides; Ribonucleotides; Thymine Nucleotides | 1972 |
Löffler's endomyocardial fibrosis with eosinophilia in association with acute lymphoblastic leukemia.
Topics: Bone Marrow Examination; Child; Chromosome Aberrations; Drug Therapy, Combination; Endomyocardial Fibrosis; Eosinophilia; Heart Murmurs; Humans; Hydrocortisone; Leukemia, Lymphoid; Liver; Lymph Nodes; Male; Mercaptopurine; Methotrexate; Myocardium; Organ Size; Pneumonia, Pneumocystis; Prednisone; Recurrence; Tachycardia; Vincristine | 1974 |
Heterogeneous chromosomal radiosensitivity of phytohaemagglutinin-stimulated human blood lymphocytes in culture.
Topics: Cells, Cultured; Chromosome Aberrations; DNA Replication; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Mitosis; Radiation Genetics | 1973 |
5-Ethyl-2'-deoxyuridine: evidence for incorporation into DNA and evaluation of biological properties in lymphocyte cultures grown under conditions of amethopterine-imposed thymidine deficiency.
Topics: Autoradiography; Bromodeoxyuridine; Carbon Radioisotopes; Cells, Cultured; Chromosome Aberrations; Culture Media; Deoxyuridine; DNA; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lymphocytes; Methotrexate; Mitosis; Thymidine; Time Factors | 1973 |
Induced chromosomal aberrations in pronuclei, 2-cell stages and morulae of mice.
Topics: Aneuploidy; Animals; Cell Division; Chromosome Aberrations; Chromosomes; Embryo, Mammalian; Female; Fertilization; Genes, Dominant; Genes, Lethal; Karyometry; Male; Methotrexate; Mice; Mice, Inbred C3H; Mitosis; Mutation; Pregnancy; Time Factors | 1973 |
Chromosome aberrations in metaphase II-oocytes. Stage sensitivity in the mouse oogenesis to amethopterin and cyclophosphamide.
Topics: Aneuploidy; Animals; Chromatin; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Genes, Dominant; Genes, Lethal; Humans; Maternal Age; Meiosis; Methotrexate; Mice; Mice, Inbred C3H; Ovulation; Ovum; Pregnancy; Time Factors | 1974 |
Induced chromosome aberrations in unfertilized oocytes of mice.
Topics: Animals; Cell Nucleolus; Chromatin; Chromosome Aberrations; Cyclophosphamide; Female; Histological Techniques; Methods; Methotrexate; Mice; Mice, Inbred Strains; Ovulation; Ovum; Quinones; Statistics as Topic | 1971 |
Drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant Chinese hamster cells in vitro.
Topics: Animals; Aspartic Acid; Benzoates; Cell Line; Chromosome Aberrations; Cricetinae; Drug Resistance; Folic Acid Antagonists; In Vitro Techniques; Karyotyping; Methotrexate; Pharmacogenetics; Quinazolines; Tetrahydrofolate Dehydrogenase | 1972 |
Cytological aberrations produced by methotrexate in mouse ascites tumours.
Topics: Animals; Cell Line; Chromatids; Chromosome Aberrations; Methotrexate; Mice; Mice, Inbred Strains; Mitosis; Neoplasms, Experimental; Polyploidy; Time Factors | 1972 |
Human mitotic and meiotic chromosome damage following in vivo exposure to methotrexate.
Topics: Adult; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; Fibroblasts; Humans; Lymphocytes; Male; Meiosis; Methotrexate; Microscopy, Polarization; Mitosis; Psoriasis; Testis | 1971 |
Meningeal involvement as first manifestation of acute myeloblastic transformation in chronic granulocytic leukemia.
Topics: Cerebrospinal Fluid; Chromosome Aberrations; Karyotyping; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Neurologic Manifestations; Prednisone; Vincristine | 1969 |
Cytogenetic remission in acute transformation of chronic granulocytic leukaemia.
Topics: Acute Disease; Aged; Aneuploidy; Bone Marrow Diseases; Busulfan; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Disorders; Chronic Disease; Female; Humans; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Prednisolone; Vincristine | 1969 |
[Congenital myelo-monocytic leukemia with aneuploid stemline].
Topics: Antibiotics, Antineoplastic; Blood Cells; Blood Transfusion; Bone Marrow Cells; Bone Marrow Examination; Chromosome Aberrations; Culture Techniques; Female; Humans; Infant; Karyotyping; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Prednisone | 1970 |
Unusual manifestations of chronic granulocytic leukemia in a child.
Topics: Busulfan; Child; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Deafness; Ear Diseases; Eye Manifestations; Female; Hemorrhagic Disorders; Humans; Leukemia, Myeloid; Methotrexate; Retina; Skin Diseases; Vestibule, Labyrinth | 1969 |
[Methotrexate treatment of psoriasis].
Topics: Chromosome Aberrations; Chromosome Disorders; Folic Acid Antagonists; Humans; Methotrexate; Psoriasis | 1969 |
[Chromosome study in patients with psoriasis treated with methotrexate].
Topics: Chromosome Aberrations; Chromosome Disorders; Chromosome Mapping; Chromosomes; Humans; Methotrexate; Psoriasis | 1970 |
[Immunosuppressive agents and cytogenetics].
Topics: Azathioprine; Chromosome Aberrations; Cytogenetics; Female; Humans; Immunosuppressive Agents; Leukemia, Radiation-Induced; Male; Meiosis; Methotrexate; Psoriasis | 1970 |
[Chromosome aberrations in peripheral leukocytes induced by antitumor agents--especially methotrexate and COPP].
Topics: Antineoplastic Agents; Chromosome Aberrations; Cobalt; Female; Humans; Leukocytes; Methotrexate; Mitomycins; Porphyrins | 1967 |
On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia.
Topics: Animals; Biological Transport, Active; Chromosome Aberrations; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Temperature; Tritium | 1968 |
Effect of chemotherapeutic agents on chromosomes of patients with lung cancer.
Topics: Adult; Antineoplastic Agents; Carcinoma, Bronchogenic; Chromosome Aberrations; Chromosomes; Cyclophosphamide; Humans; Hydroxyurea; Lung Neoplasms; Methotrexate; Streptonigrin | 1969 |
Methotrexate and psoriasis.
Topics: Chemical and Drug Induced Liver Injury; Chromosome Aberrations; Humans; Liver Function Tests; Methotrexate; Psoriasis | 1969 |
Cytogenetic evaluation of methotrexate-treated psoriatic patients.
Topics: Adolescent; Adult; Chromatids; Chromosome Aberrations; Chromosomes; Culture Techniques; Female; Humans; Leukocytes; Male; Methotrexate; Middle Aged; Psoriasis | 1969 |
Chromosomal abnormalities produced by folic acid antagonists.
Topics: Aminopterin; Chromosome Aberrations; Chromosome Disorders; Culture Techniques; Humans; Karyotyping; Lymphocytes; Methotrexate; Psoriasis | 1965 |
Conference on obstacles to the control of acute leukemia. Formal discussion: long-term survivors.
Topics: Antimetabolites; Blood Cell Count; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Cyclophosphamide; Humans; Leukemia; Mercaptopurine; Methotrexate; Mutation; Prognosis; Steroids | 1965 |