methocarbamol and Acute Pain studies

Methocarbamol: A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
methocarbamol : A racemate comprising equimolar amounts of (R)- and (S)-methocarbamol. A centrally acting skeletal muscle relaxant, it is used as an adjunct in the short-term symptomatic treatment of painful muscle spasm. The (R)-enantiomer is more active than the (S)-enantiomer.
2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate : A carbamate ester that is glycerol in which one of the primary alcohol groups has been converted to its 2-methoxyphenyl ether while the other has been converted to the corresponding carbamate ester.

Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.

Research Excerpts

Excerpt	Relevance	Reference
"Among ED patients with acute, nontraumatic, nonradicular low back pain, combining naproxen with either orphenadrine or methocarbamol did not improve functional outcomes compared with naproxen+placebo."	9.27	A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. ( Cisewski, D; Davitt, M; Friedman, BW; Gallagher, EJ; Irizarry, E; Nassery, A; Pearlman, S; Solorzano, C; White, D, 2018)
"Muscle relaxants are widely used to treat low back pain (LBP), one of the most frequent health problems in industrialized countries."	6.80	[Methocarbamol in acute low back pain. A randomized double-blind controlled study]. ( Emrich, OM; Milachowski, KA; Strohmeier, M, 2015)
"Among ED patients with acute, nontraumatic, nonradicular low back pain, combining naproxen with either orphenadrine or methocarbamol did not improve functional outcomes compared with naproxen+placebo."	5.27	A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. ( Cisewski, D; Davitt, M; Friedman, BW; Gallagher, EJ; Irizarry, E; Nassery, A; Pearlman, S; Solorzano, C; White, D, 2018)
"Muscle relaxants are widely used to treat low back pain (LBP), one of the most frequent health problems in industrialized countries."	2.80	[Methocarbamol in acute low back pain. A randomized double-blind controlled study]. ( Emrich, OM; Milachowski, KA; Strohmeier, M, 2015)

Research

Studies (4)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Cases of Moderate or Severe LBP

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (50.00)	24.3611
2020's	2 (50.00)	2.80

Authors	Studies
Abril, L	1
Zamora, C	1
Cordero, M	1
Williams, AR	1
Friedman, BW	2
Sharifi, M	1
Abdorazzaghnejad, A	1
Yazdchi, M	1
Bahreini, M	1
Cisewski, D	1
Irizarry, E	1
Davitt, M	1
Solorzano, C	1
Nassery, A	1
Pearlman, S	1
White, D	1
Gallagher, EJ	1
Emrich, OM	1
Milachowski, KA	1
Strohmeier, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Methocarbamol and Orphenadrine for Acute, Non-traumatic, Non-radicular Low Back Pain: A Randomized, Placebo Controlled, 3-armed Study[NCT02665286]	Phase 4	240 participants (Actual)	Interventional	2016-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Participants with moderate to severe low back pain after treatment as report on the following ordinal scale: severe, moderate, mild, or none (NCT02665286)
Timeframe: 1 week

Functional Impairment as Measured on the Roland Morris Disability Questionnaire

Intervention	Participants (Count of Participants)
Placebo	34
Orphenadrine	26
Methocarbamol	31

"Change in Roland Morris Disability Questionnaire between baseline and 1 week.~The low back pain functional disability scale is the RMDQ. The RMDQ is a 24-item low back pain functional scale recommended for use in low back pain research.Higher scores signify greater low back-related functional impairment.0= no functional impairment, 24= severe functional impairment." (NCT02665286)
Timeframe: 1 week

Medications--Patient Self Report of Medication Use

Intervention	units on a scale (Mean)
Placebo	10.9
Orphenadrine	9.4
Methocarbamol	8.1

Participants still using medication such as analgesics for LBP after treatment (NCT02665286)
Timeframe: 1 week

Patient Satisfaction With Treatment

Intervention	Participants (Count of Participants)
Placebo	42
Orphenadrine	40
Methocarbamol	50

The number of participants with affirmative response to the following question: Do you want the same medication combination during a subsequent episode of LBP. This is a patient-centered outcome that allows each individual to determine the desirability of the intervention. (NCT02665286)
Timeframe: 1 week

Article	Year
Methocarbamol versus diazepam in acute low back pain in the emergency department: a randomised double-blind clinical trial. Emergency medicine journal : EMJ, 2023, Volume: 40, Issue:7 Topics: Acute Pain; Diazepam; Double-Blind Method; Emergency Service, Hospital; Humans; Low Back Pain; Metho	2023
A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. Annals of emergency medicine, 2018, Volume: 71, Issue:3 Topics: Acute Pain; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Rela	2018
[Methocarbamol in acute low back pain. A randomized double-blind controlled study]. MMW Fortschritte der Medizin, 2015, Volume: 157 Suppl 5 Topics: Acute Pain; Administration, Oral; Adult; Double-Blind Method; Female; Humans; Low Back Pain; Male; M	2015

methocarbamol and Acute Pain