methiothepin has been researched along with Seizures in 2 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Kainic acid induces seizures and neurotoxicity in rats, produces changes in brain serotonin (5-HT), dopamine and noradrenaline metabolites among other changes in neurotransmitters." | 3.72 | Changes in brain serotonin turnover, body and head shakes in kainic acid-treated rats. ( Mancera-Flores, M; Osorio-Rico, L; Ríos, C, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Freitas, RL | 1 |
| Ferreira, CM | 1 |
| Urbina, MA | 1 |
| Mariño, AU | 1 |
| Carvalho, AD | 1 |
| Butera, G | 1 |
| de Oliveira, AM | 1 |
| Coimbra, NC | 1 |
| Osorio-Rico, L | 1 |
| Mancera-Flores, M | 1 |
| Ríos, C | 1 |
2 other studies available for methiothepin and Seizures
| Article | Year |
|---|---|
5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: role of dorsal raphe nucleus.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; GABA Antagonists; | 2009 |
Changes in brain serotonin turnover, body and head shakes in kainic acid-treated rats.
Topics: Amygdala; Animals; Behavior, Animal; Brain; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid | 2003 |