methiothepin has been researched along with Pregnancy in 7 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Placental choriocarcinoma is a malignant trophoblastic tumor associated with placentation." | 5.56 | Tumor-suppressive function of methiothepin in human placental choriocarcinoma cells. ( Lee, JY; Lim, W; Song, G, 2020) |
| "Placental choriocarcinoma is a malignant trophoblastic tumor associated with placentation." | 1.56 | Tumor-suppressive function of methiothepin in human placental choriocarcinoma cells. ( Lee, JY; Lim, W; Song, G, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, JY | 1 |
| Lim, W | 1 |
| Song, G | 1 |
| Karlsson, C | 1 |
| Bodelsson, G | 1 |
| Bodelsson, M | 1 |
| Stjernquist, M | 1 |
| Yan, QS | 1 |
| Trentini, GP | 1 |
| Mess, B | 1 |
| De Gaetani, CF | 1 |
| Ruzsás, C | 1 |
| Jahn, GA | 1 |
| Deis, RP | 1 |
| Dumuis, A | 1 |
| Bouhelal, R | 1 |
| Sebben, M | 1 |
| Bockaert, J | 1 |
| Lucot, JB | 1 |
| Seiden, LS | 1 |
7 other studies available for methiothepin and Pregnancy
| Article | Year |
|---|---|
Tumor-suppressive function of methiothepin in human placental choriocarcinoma cells.
Topics: Apoptosis; Cell Movement; Cell Proliferation; Choriocarcinoma; Female; Humans; MAP Kinase Signaling | 2020 |
Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery.
Topics: Adolescent; Adult; Female; Humans; Ketanserin; Methiothepin; Muscle Contraction; Muscle, Smooth; Pre | 1999 |
Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.
Topics: Animals; Animals, Newborn; Citalopram; Cocaine; Cocaine-Related Disorders; Electric Stimulation; Fem | 2002 |
Effect of melatonin on induction of ovulation in the light- induced constant estrous-anovulatory syndrome and possible role of the brain serotoninergic system.
Topics: Animals; Anovulation; Estrus; Female; Light; Melatonin; Methiothepin; Ovulation; Pineal Gland; Pregn | 1978 |
A possible dual regulation of prolactin release by the serotoninergic system in rats at pro-oestrus and during late pregnancy: role of ovarian hormones.
Topics: Animals; Estradiol; Estrus; Female; Fenclonine; Humans; Methiothepin; Ovariectomy; Pregnancy; Pregna | 1987 |
A 5-HT receptor in the central nervous system, positively coupled with adenylate cyclase, is antagonized by ICS 205 930.
Topics: Adenylyl Cyclases; Animals; Brain; Female; Indoles; Ketanserin; Male; Methiothepin; Mice; Pregnancy; | 1988 |
Effects of serotonergic agonists and antagonists on the locomotor activity of neonatal rats.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Cinanserin; Female; Methiothepin; Methysergid | 1986 |