methiothepin has been researched along with Pain, Postoperative in 1 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paw skin incision is a well-established postoperative pain model that causes behavioral nociceptive responses and enhanced excitability of spinal dorsal horn neurons." | 1.36 | Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats. ( Del Bel, EA; Dias, QM; Prado, WA; Silveira, JW, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Silveira, JW | 1 |
| Dias, QM | 1 |
| Del Bel, EA | 1 |
| Prado, WA | 1 |
1 other study available for methiothepin and Pain, Postoperative
| Article | Year |
|---|---|
Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats.
Topics: Animals; Atropine; Cholinergic Antagonists; Immunohistochemistry; Ketanserin; Male; Methiothepin; Me | 2010 |