methiothepin has been researched along with Neuralgia in 1 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tactile allodynia in neuropathic rats was assessed with von Frey filaments." | 1.42 | Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats. ( Avila-Rojas, SH; Barragán-Iglesias, P; Granados-Soto, V; Pineda-Farias, JB; Salinas-Abarca, AB; Velázquez-Lagunas, I, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avila-Rojas, SH | 1 |
| Velázquez-Lagunas, I | 1 |
| Salinas-Abarca, AB | 1 |
| Barragán-Iglesias, P | 1 |
| Pineda-Farias, JB | 1 |
| Granados-Soto, V | 1 |
1 other study available for methiothepin and Neuralgia
| Article | Year |
|---|---|
Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; Ganglia, Spinal; Hyperalgesia; Lumbar | 2015 |