methiothepin has been researched along with Myoclonic Jerk in 2 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In guinea pigs, myoclonus can be induced by 5-hydroxytryptamine (5-HT, serotonin) precursors and synthetic 5-HT receptor agonists, yet the receptor subtype specificity of this behavior is not fully delineated." | 1.30 | 5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes. ( Belden, M; Carvey, PM; Goetz, CG; Pappert, EJ; Stebbins, GT, 1998) |
| " Drugs that produced a significant decrease in myoclonus compared with the control were studied in a dose-response study with six doses across a range from the original dose studied to 10% of that dose." | 1.30 | Animal model of posthypoxic myoclonus: effects of serotonergic antagonists. ( Carvey, PM; Goetz, CG; Leurgans, S; Ling, ZD; Pappert, EJ; Raman, R; Vu, TQ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pappert, EJ | 2 |
| Goetz, CG | 2 |
| Stebbins, GT | 1 |
| Belden, M | 1 |
| Carvey, PM | 2 |
| Vu, TQ | 1 |
| Ling, ZD | 1 |
| Leurgans, S | 1 |
| Raman, R | 1 |
2 other studies available for methiothepin and Myoclonic Jerk
| Article | Year |
|---|---|
5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Ergolines; Guinea Pigs; Male; Methioth | 1998 |
Animal model of posthypoxic myoclonus: effects of serotonergic antagonists.
Topics: Acoustic Stimulation; Animals; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, | 1999 |