methiothepin has been researched along with Muscle Relaxation in 8 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mizuno, R | 1 |
| Ohhashi, T | 2 |
| Kojima, S | 1 |
| Ishizaki, R | 1 |
| Shimo, Y | 1 |
| Sevcík, J | 1 |
| Ruzicka, V | 1 |
| Slánsky, J | 1 |
| Masek, K | 1 |
| Wang, JX | 1 |
| Ikomi, F | 1 |
| O'Dowd, A | 1 |
| Miller, DJ | 1 |
| Park, SJ | 1 |
| Nakashima, M | 1 |
| Nagao, T | 1 |
| Vanhoutte, PM | 2 |
| Humphrey, PP | 1 |
| Feniuk, W | 1 |
| Perren, MJ | 1 |
| Connor, HE | 1 |
| Oxford, AW | 1 |
| Coates, LH | 1 |
| Butina, D | 1 |
| Houston, DS | 1 |
| Shepherd, JT | 1 |
8 other studies available for methiothepin and Muscle Relaxation
| Article | Year |
|---|---|
5-Hydroxytryptamine-induced NO-dependent relaxation in isolated strips of monkey popliteal lymph nodes.
Topics: Animals; Arginine; Aspirin; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Ketanseri | 1995 |
Investigation of nicotine-induced relaxation of circular smooth muscle of the guinea-pig gastric fundus.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Chymotrypsin; Drug Interactions; Gastric Fundus; Guin | 1993 |
Which type of 5-hydroxytryptamine receptor mediates relaxation of the longitudinal muscle of guinea pig proximal colon in vitro?
Topics: Animals; Colon; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Indoles; Ketanse | 1996 |
5-Hydroxytryptamine-induced endothelium-dependent and -independent relaxations in isolated dog anterior spinal small arteries.
Topics: Animals; Arteries; Aspirin; Dogs; Endothelium, Vascular; Epoprostenol; Female; Fibrinolytic Agents; | 1997 |
Analysis of an H1 receptor-mediated, zinc-potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnosine; Cimetidine; Drug Interactions; Histamin | 1998 |
Hyperpolarization caused by serotonin contributes to endothelium-dependent relaxations in the porcine coronary artery.
Topics: Animals; Coronary Vessels; Endothelium, Vascular; Male; Membrane Potentials; Methiothepin; Muscle Re | 1999 |
GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein.
Topics: Animals; Cats; Dogs; Female; In Vitro Techniques; Indoles; Male; Methiothepin; Muscle Contraction; M | 1988 |
Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides.
Topics: Adenine Nucleotides; Animals; Coronary Vessels; Dogs; Endothelium; Female; Humans; Imidazoles; In Vi | 1986 |