methiothepin has been researched along with Muscle Contraction in 31 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Strips from rabbits with colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) were subjected to electrical field stimulation." | 3.72 | Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation. ( Depoortere, I; Peeters, TL; Thielemans, L; Thijs, T, 2003) |
| " Long-term administration of lithium decreased the number of not only 5-HT2 receptors in the frontal cortex but also 5-HT1 and 5-HT2 receptors in the hippocampus in rats." | 1.27 | Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain. ( Hotta, I; Segawa, T; Yamawaki, S, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (35.48) | 18.7374 |
| 1990's | 19 (61.29) | 18.2507 |
| 2000's | 1 (3.23) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Depoortere, I | 1 |
| Thijs, T | 1 |
| Thielemans, L | 1 |
| Peeters, TL | 1 |
| MacLean, MR | 1 |
| Clayton, RA | 1 |
| Hillis, SW | 1 |
| McIntyre, PD | 1 |
| Peacock, AJ | 1 |
| Templeton, AG | 1 |
| Martín, MT | 1 |
| Fernández, E | 1 |
| Fernández, AG | 1 |
| Goñalons, E | 1 |
| Messori, E | 1 |
| Rizzi, CA | 2 |
| Candura, SM | 2 |
| Lucchelli, A | 1 |
| Balestra, B | 1 |
| Tonini, M | 2 |
| Bingham, S | 1 |
| King, BF | 1 |
| Rushant, B | 1 |
| Smith, MI | 1 |
| Gaster, L | 1 |
| Sanger, GJ | 1 |
| Mizuno, R | 1 |
| Ohhashi, T | 2 |
| Miyamoto, A | 2 |
| Sakota, T | 1 |
| Nishio, A | 2 |
| Obi, T | 1 |
| Kojima, S | 1 |
| Shimo, Y | 1 |
| Nishimura, Y | 1 |
| Sevcík, J | 1 |
| Ruzicka, V | 1 |
| Slánsky, J | 1 |
| Masek, K | 1 |
| Wang, JX | 1 |
| Ikomi, F | 1 |
| Bailey, SR | 1 |
| Elliott, J | 1 |
| Teng, GQ | 1 |
| Williams, J | 1 |
| Zhang, L | 1 |
| Purdy, R | 1 |
| Pearce, WJ | 1 |
| O'Dowd, A | 1 |
| Miller, DJ | 1 |
| Karlsson, C | 1 |
| Bodelsson, G | 1 |
| Bodelsson, M | 1 |
| Stjernquist, M | 1 |
| Coccini, T | 1 |
| Onori, L | 1 |
| Manzo, L | 1 |
| Bond, RA | 1 |
| Vanhoutte, PM | 5 |
| Parsons, AA | 1 |
| Motevalian, M | 1 |
| Whalley, ET | 1 |
| Terron, JA | 1 |
| Hong, E | 1 |
| Demolle, D | 1 |
| Van Coevorden, A | 1 |
| Boeynaems, JM | 1 |
| Humphrey, PP | 1 |
| Feniuk, W | 1 |
| Perren, MJ | 1 |
| Connor, HE | 1 |
| Oxford, AW | 1 |
| Coates, LH | 1 |
| Butina, D | 1 |
| Costall, B | 1 |
| Gunning, SJ | 1 |
| Naylor, RJ | 1 |
| Tattersall, FD | 1 |
| Van Nueten, JM | 1 |
| Janssens, WJ | 1 |
| Cohen, RA | 2 |
| Houston, DS | 2 |
| Shepherd, JT | 2 |
| Kilbinger, H | 1 |
| Pfeuffer-Friederich, I | 1 |
| Hotta, I | 1 |
| Yamawaki, S | 1 |
| Segawa, T | 1 |
| Zitnay, KM | 1 |
| Weisbrod, RM | 1 |
| Lorenz, RR | 1 |
1 review available for methiothepin and Muscle Contraction
| Article | Year |
|---|---|
Serotonin and vascular reactivity.
Topics: Animals; Blood Platelets; Calcium; Cold Temperature; Electric Stimulation; Hypoxia; Ketanserin; Lido | 1985 |
30 other studies available for methiothepin and Muscle Contraction
| Article | Year |
|---|---|
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; I | 2003 |
5-HT1-receptor-mediated vasoconstriction in bovine isolated pulmonary arteries: influences of vascular endothelium and tone.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cattle; Drug Interactions; Endothelium, Vascular; In | 1994 |
Mechanisms mediating the effects of cholecystokinin on avian small intestine longitudinal smooth muscle.
Topics: Acetylcholine; Amino Acid Sequence; Analysis of Variance; Animals; Chickens; Cholecystokinin; Dose-R | 1994 |
5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Amphetamines; Animals; Dose-Response Relationship, Drug; Elec | 1995 |
Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function.
Topics: 4-Aminobenzoic Acid; Animals; Atropine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Drug Inter | 1995 |
5-Hydroxytryptamine-induced NO-dependent relaxation in isolated strips of monkey popliteal lymph nodes.
Topics: Animals; Arginine; Aspirin; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Ketanseri | 1995 |
Characterization of 5-hydroxytryptamine receptors on the isolated pig basilar artery by functional and radioligand binding studies.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basilar Artery; Binding, Competitive; Dose-Response | 1994 |
The vasomotor effects of 5-hydroxytryptamine on equine basilar arteries in vitro.
Topics: Animals; Basilar Artery; Dose-Response Relationship, Drug; Horses; Ketanserin; Methiothepin; Muscle | 1996 |
Investigation into the 5-hydroxytryptamine-induced atropine-resistant neurogenic contraction of guinea-pig proximal colon.
Topics: 5-Methoxytryptamine; Animals; Atropine; Colon; Dipeptides; Dose-Response Relationship, Drug; Guinea | 1996 |
Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Basilar Artery; Dose-Response Relationship, Drug; In Vitro Techniques; Ketanserin; Male; Me | 1996 |
Which type of 5-hydroxytryptamine receptor mediates relaxation of the longitudinal muscle of guinea pig proximal colon in vitro?
Topics: Animals; Colon; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Indoles; Ketanse | 1996 |
5-Hydroxytryptamine-induced endothelium-dependent and -independent relaxations in isolated dog anterior spinal small arteries.
Topics: Animals; Arteries; Aspirin; Dogs; Endothelium, Vascular; Epoprostenol; Female; Fibrinolytic Agents; | 1997 |
Plasma 5-hydroxytryptamine constricts equine digital blood vessels in vitro: implications for pathogenesis of acute laminitis.
Topics: Animals; Arteries; Chromatography, High Pressure Liquid; Coronary Vessels; Dose-Response Relationshi | 1998 |
Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Carotid Artery, Common; Cerebral Arteries; F | 1998 |
Analysis of an H1 receptor-mediated, zinc-potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnosine; Cimetidine; Drug Interactions; Histamin | 1998 |
Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery.
Topics: Adolescent; Adult; Female; Humans; Ketanserin; Methiothepin; Muscle Contraction; Muscle, Smooth; Pre | 1999 |
The influence of neuronal 5-hydroxytryptamine receptor antagonists on non-cholinergic ganglionic transmission in the guinea-pig enteric excitatory reflex.
Topics: Animals; Benzamides; Benzimidazoles; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyc | 1992 |
Interaction of tertatolol at the "atypical" or beta 3-adrenoceptor in guinea-pig ileum.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Electric Stimulation; Ethanolamines; | 1992 |
Contractile effects of 8-hydroxy-2-(di-n-propylamino)tetralin and flesinoxan in human isolated basilar artery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Antihypertensive Agents; Basilar Artery; Humans; In Vitro Te | 1991 |
Effects of 2-(5-methoxy-3-indolyl)-3-aminopropanol (TR-3661) on the canine basilar artery.
Topics: Animals; Aorta, Thoracic; Basilar Artery; Dogs; In Vitro Techniques; Indoles; Methiothepin; Muscle C | 1991 |
Stimulation of aortic smooth muscle prostacyclin by serotonin: role of distinct receptors in contractile and synthetic states.
Topics: Animals; Aorta, Thoracic; Cattle; Cells, Cultured; Epoprostenol; Ketanserin; Methiothepin; Muscle Co | 1989 |
GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein.
Topics: Animals; Cats; Dogs; Female; In Vitro Techniques; Indoles; Male; Methiothepin; Muscle Contraction; M | 1988 |
Modification of electrical field stimulation-induced contractions in the guinea-pig ileum by metoclopramide and ICS 205-930 depends on the integrity of the mucosa.
Topics: Animals; Drug Interactions; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; | 1986 |
Adenine nucleotides and 5-hydroxytryptamine released by aggregating platelets inhibit adrenergic neurotransmission in canine coronary artery.
Topics: Adenosine Diphosphate; Animals; Arteries; Coronary Vessels; Dinoprost; Dogs; Electric Stimulation; M | 1986 |
Adenine nucleotides, serotonin, and endothelium-dependent relaxations to platelets.
Topics: Adenine Nucleotides; Animals; Apyrase; Blood Platelets; Coronary Vessels; Dogs; Endothelium; Female; | 1985 |
Two types of receptors for 5-hydroxytryptamine on the cholinergic nerves of the guinea-pig myenteric plexus.
Topics: Acetylcholine; Animals; Binding, Competitive; Cocaine; Electric Stimulation; Female; Guinea Pigs; Ke | 1985 |
Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Brain; Frontal Lobe; Head; Hippocampus; In Vitro Techniques; Ketanseri | 1986 |
Accumulation of 5-hydroxytryptamine leads to dysfunction of adrenergic nerves in canine coronary artery following intimal damage in vivo.
Topics: Acetylcholine; Animals; Catheterization; Coronary Disease; Coronary Vessels; Dogs; Electric Stimulat | 1987 |
Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides.
Topics: Adenine Nucleotides; Animals; Coronary Vessels; Dogs; Endothelium; Female; Humans; Imidazoles; In Vi | 1986 |
Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels.
Topics: Animals; Blood Platelets; Coronary Vessels; Dogs; Electric Stimulation; In Vitro Techniques; Methiot | 1985 |