methiothepin has been researched along with Hypoxia in 2 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Drugs that produced a significant decrease in myoclonus compared with the control were studied in a dose-response study with six doses across a range from the original dose studied to 10% of that dose." | 1.30 | Animal model of posthypoxic myoclonus: effects of serotonergic antagonists. ( Carvey, PM; Goetz, CG; Leurgans, S; Ling, ZD; Pappert, EJ; Raman, R; Vu, TQ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pappert, EJ | 1 |
| Goetz, CG | 1 |
| Vu, TQ | 1 |
| Ling, ZD | 1 |
| Leurgans, S | 1 |
| Raman, R | 1 |
| Carvey, PM | 1 |
| Van Nueten, JM | 1 |
| Janssens, WJ | 1 |
| Vanhoutte, PM | 1 |
1 review available for methiothepin and Hypoxia
| Article | Year |
|---|---|
Serotonin and vascular reactivity.
Topics: Animals; Blood Platelets; Calcium; Cold Temperature; Electric Stimulation; Hypoxia; Ketanserin; Lido | 1985 |
1 other study available for methiothepin and Hypoxia
| Article | Year |
|---|---|
Animal model of posthypoxic myoclonus: effects of serotonergic antagonists.
Topics: Acoustic Stimulation; Animals; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, | 1999 |