methiothepin has been researched along with Decerebrate Posturing in 3 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with methiothepin and mesulergine, but not clozapine, inhibited (R)-8-OH-DPAT-induced monosynaptic reflex depression." | 1.31 | No involvement of 5-HT(7) or 5-HT(1D) receptors in the (R)-8-OH-DPAT-induced depression of the monosynaptic reflex in spinalized rats. ( Honda, M; Ono, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koshizaki, M | 1 |
| Kawamata, M | 1 |
| Shimada, SG | 1 |
| Saito, Y | 1 |
| Collins, JG | 1 |
| Centurión, D | 1 |
| Mehotra, S | 1 |
| Sánchez-López, A | 1 |
| Gupta, S | 1 |
| MaassenVanDenBrink, A | 1 |
| Villalón, CM | 1 |
| Honda, M | 1 |
| Ono, H | 1 |
3 other studies available for methiothepin and Decerebrate Posturing
| Article | Year |
|---|---|
5-HT3 receptors partially mediate halothane depression of spinal dorsal horn sensory neurons.
Topics: Anesthetics, Inhalation; Animals; Decerebrate State; Depression, Chemical; Halothane; Indoles; Ketan | 2003 |
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Rec | 2006 |
No involvement of 5-HT(7) or 5-HT(1D) receptors in the (R)-8-OH-DPAT-induced depression of the monosynaptic reflex in spinalized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Decerebrate State; Dose-Response Relatio | 2001 |