methiothepin has been researched along with Alzheimer Disease in 1 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wichur, T | 1 |
| Godyń, J | 1 |
| Góral, I | 1 |
| Latacz, G | 1 |
| Bucki, A | 1 |
| Siwek, A | 1 |
| Głuch-Lutwin, M | 1 |
| Mordyl, B | 1 |
| Śniecikowska, J | 1 |
| Walczak, M | 1 |
| Knez, D | 1 |
| Jukič, M | 1 |
| Sałat, K | 1 |
| Gobec, S | 1 |
| Kołaczkowski, M | 1 |
| Malawska, B | 1 |
| Brazzolotto, X | 1 |
| Więckowska, A | 1 |
1 other study available for methiothepin and Alzheimer Disease
| Article | Year |
|---|---|
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cell Survival; Cholinester | 2021 |