methiothepin has been researched along with Aging in 8 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petrascheck, M | 1 |
| Ye, X | 1 |
| Buck, LB | 1 |
| Birthelmer, A | 1 |
| Stemmelin, J | 1 |
| Jackisch, R | 1 |
| Cassel, JC | 1 |
| Docherty, JR | 1 |
| Teng, GQ | 1 |
| Williams, J | 1 |
| Zhang, L | 1 |
| Purdy, R | 1 |
| Pearce, WJ | 1 |
| Bourgoin, S | 1 |
| Artaud, F | 1 |
| Enjalbert, A | 1 |
| Héry, F | 1 |
| Glowinski, J | 1 |
| Hamon, M | 1 |
| Urbá-Holmgren, R | 1 |
| Holmgren, B | 1 |
| Leon, BA | 1 |
| Ugarte, A | 1 |
| Schlicker, E | 1 |
| Betz, R | 1 |
| Göthert, M | 1 |
| Lucot, JB | 1 |
| Seiden, LS | 1 |
8 other studies available for methiothepin and Aging
| Article | Year |
|---|---|
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevit | 2007 |
Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; | 2003 |
Aging and vasoconstrictor responses mediated by alpha 2-adrenoceptors and 5-HT1 and 5-HT2 receptors.
Topics: Adult; Aged; Aging; Animals; Female; Humans; In Vitro Techniques; Ketanserin; Male; Methiothepin; Mi | 1994 |
Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Carotid Artery, Common; Cerebral Arteries; F | 1998 |
Acute changes in central serotonin metabolism induced by the blockade or stimulation of serotoninergic receptors during ontogenesis in the rat.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Brain; Female; Hydroxyindoleacetic Acid; In Vit | 1977 |
Age-dependent changes in serotonergic modulation of yawning in the rat.
Topics: Aging; Animals; Citalopram; Male; Methiothepin; Physostigmine; Rats; Rats, Sprague-Dawley; Ritanseri | 1992 |
Investigation into the age-dependence of release of serotonin and noradrenaline in the rat brain cortex and of autoreceptor-mediated modulation of release.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Cerebral Cortex; Electric S | 1989 |
Effects of serotonergic agonists and antagonists on the locomotor activity of neonatal rats.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Cinanserin; Female; Methiothepin; Methysergid | 1986 |