methionine sulfoximine has been researched along with Disease Models, Animal in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.29) | 18.7374 |
| 1990's | 8 (22.86) | 18.2507 |
| 2000's | 3 (8.57) | 29.6817 |
| 2010's | 17 (48.57) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Acewicz, A; Albrecht, J; Czarnecka, AM; Czuczwar, SJ; Kołodziej, M; Obara-Michlewska, M; Pawlik, MJ; Popek, MP; Wierzba-Bobrowicz, T; Łuszczki, J | 1 |
| Coman, D; Dhaher, R; Eid, T; Huang, Y; Hyder, F; Munbodh, R; Wang, H; Zaveri, HP | 1 |
| Bame, M; Brusilow, WS; Grier, RE; Needleman, R | 1 |
| Damisah, EC; Dhaher, R; Eid, T; Gruenbaum, BF; Gruenbaum, SE; Ong, C; Wang, H; Zaveri, HP | 1 |
| Dhaher, R; Eid, T; Gruenbaum, SE; Lee, TS; Tu, N; Wang, H; Zaveri, HP | 1 |
| Dhaher, R; Eid, T; Gruenbaum, SE; Lee, TS; Tang, AB; Wang, H; Zaveri, HP | 1 |
| Bai, XY; Chen, XM; Deng, DP; Li, SC; Liu, YX; Pan, XH; Sun, HL; Wang, CH; Wang, CY; Zhang, XL; Zhu, W | 1 |
| Albright, B; Dhaher, R; Eid, T; Harb, R; Lee, TW; Wang, H; Zaveri, H | 1 |
| Brusilow, WS; Peters, TJ | 1 |
| Cloix, JF; Hévor, T | 1 |
| Eid, T; Lee, TS; Wang, Y; Zaveri, HP | 1 |
| Cloix, JF; Hévor, T; Martin, B; Tahi, Z | 1 |
| Bame, M; Brusilow, WS; Galloway, MP; Ghoddoussi, F; Jambekar, A; Needleman, R | 1 |
| Chiang, CY; Dostrovsky, JO; Hu, JW; Iwata, K; Sessle, BJ; Tsuboi, Y | 1 |
| Bernardi, P; Brusilow, WS; Chiara, F; Jambekar, AA; Needleman, R; Nicolosi, L; Palma, E; Petronilli, V; Rasola, A | 1 |
| Ishikawa, M; Izumi, Y; Yoshitomi, T; Zorumski, CF | 1 |
| Bergersen, LH; Chaudhry, FA; Eid, T; Kang, D; Lauritzen, F; Lee, TS; Ottersen, OP; Perez, EL; Wang, Y; Zaveri, HP | 1 |
| Bame, M; Brusilow, WS; Needleman, R; Pentiak, PA | 1 |
| Boissonnet, A; Cloix, JF; Hévor, T; Landemarre, L | 1 |
| Harth, G; Horwitz, MA | 1 |
| Li, Y; Trush, MA; Zhu, H | 1 |
| Fujihara, Y; Iguchi, S; Kaneo, Y; Ogawa, K; Tanaka, T | 1 |
| Adrian, TE; Bagchi, D; Hinder, RA; Kretchmar, DH; Perdikis, G; Redmond, EJ; Stinson, RG; Wetscher, GJ | 1 |
| Gandolfi, AJ; Hall, PM; Lind, RC | 1 |
| McQueen, JK; Woodbury, DM | 1 |
| Kitamoto, K; Nagasawa, T; Soejima, A; Suzuki, M; Waku, M | 1 |
| Broquist, HP | 1 |
| Lewellyn, AL; Parchment, RE; Pierce, GB | 1 |
| Fujii, K; Kitahara, S; Ohtsu, A | 1 |
| Brumback, RA; Lapham, LW | 1 |
| Deeg, HJ; Luk, K; Shulman, HM; Shuman, WB; Storb, R | 1 |
| Calvin, HI; Medvedovsky, C; Worgul, BV | 1 |
| De Robertis, E | 1 |
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
3 review(s) available for methionine sulfoximine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic effects of methionine sulfoximine in multiple diseases include and extend beyond inhibition of glutamine synthetase.
Topics: Amyotrophic Lateral Sclerosis; Animals; Brain Edema; Disease Models, Animal; Drug Design; Glutamate-Ammonia Ligase; Hepatic Encephalopathy; Humans; Methionine Sulfoximine; Molecular Targeted Therapy; Stroke | 2017 |
Epilepsy, regulation of brain energy metabolism and neurotransmission.
Topics: Animals; Brain; Disease Models, Animal; Energy Metabolism; Epilepsy; Glycogen; Humans; Methionine Sulfoximine; Synaptic Transmission | 2009 |
Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants.
Topics: Animals; Animals, Newborn; Antioxidants; Ascorbic Acid; Buthionine Sulfoximine; Disease Models, Animal; Glutathione; Methionine Sulfoximine; Rats | 1992 |
32 other study(ies) available for methionine sulfoximine and Disease Models, Animal
| Article | Year |
|---|---|
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Topics: Animals; Brain; Disease Models, Animal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Pilocarpine; Rats, Sprague-Dawley; Seizures | 2021 |
Network evolution in mesial temporal lobe epilepsy revealed by diffusion tensor imaging.
Topics: Animals; Brain; Diffusion Magnetic Resonance Imaging; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; Glutamate-Ammonia Ligase; Hippocampus; Image Enhancement; Image Interpretation, Computer-Assisted; Male; Methionine Sulfoximine; Nerve Net; Rats; Rats, Sprague-Dawley; Time Factors | 2017 |
Amino acids as biomarkers in the SOD1(G93A) mouse model of ALS.
Topics: Age Factors; Amino Acids; Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Disease Models, Animal; Female; Glutamate-Ammonia Ligase; Humans; Longevity; Male; Metabolome; Methionine Sulfoximine; Methylation; Mice; Mice, Transgenic; Mutation; Sex Factors; Superoxide Dismutase; Superoxide Dismutase-1 | 2014 |
5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy.
Topics: Amino Acids, Neutral; Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Seizures | 2014 |
Effects of site-specific infusions of methionine sulfoximine on the temporal progression of seizures in a rat model of mesial temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain; Disease Models, Animal; Disease Progression; Electrocorticography; Epilepsy, Temporal Lobe; Glutamate-Ammonia Ligase; Infusions, Intraventricular; Infusions, Parenteral; Male; Methionine Sulfoximine; Rats, Sprague-Dawley; Seizures; Video Recording | 2015 |
Inhibition of glutamine synthetase in the central nucleus of the amygdala induces anhedonic behavior and recurrent seizures in a rat model of mesial temporal lobe epilepsy.
Topics: Amygdala; Analysis of Variance; Anhedonia; Animals; Brain; Central Amygdaloid Nucleus; Comorbidity; Depressive Disorder; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy, Temporal Lobe; Glutamate-Ammonia Ligase; Hippocampus; Male; Methionine Sulfoximine; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2015 |
A sub-threshold dose of pilocarpine increases glutamine synthetase in reactive astrocytes and enhances the progression of amygdaloid-kindling epilepsy in rats.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Basolateral Nuclear Complex; Catheters, Indwelling; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Hippocampus; Kindling, Neurologic; Lithium Chloride; Male; Methionine Sulfoximine; Muscarinic Agonists; Pilocarpine; Rats, Sprague-Dawley; Temporal Lobe | 2016 |
Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition.
Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Glutamate-Ammonia Ligase; Hippocampus; Male; Methionine Sulfoximine; Muscarinic Agonists; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; Video Recording | 2017 |
The development of recurrent seizures after continuous intrahippocampal infusion of methionine sulfoximine in rats: a video-intracranial electroencephalographic study.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Injections; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Seizures; Stereotaxic Techniques; Terminology as Topic | 2009 |
Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures.
Topics: Animals; Cerebral Cortex; Convulsants; Crosses, Genetic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Female; Kainic Acid; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Pentylenetetrazole; Reaction Time; Seizures; Selection, Genetic | 2010 |
Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Glutathione; Humans; Kaplan-Meier Estimate; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Mice; Mice, Transgenic; Motor Cortex; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Treatment Outcome | 2010 |
Modulation of astroglial glutamine synthetase activity affects nociceptive behaviour and central sensitization of medullary dorsal horn nociceptive neurons in a rat model of chronic pulpitis.
Topics: Animals; Astrocytes; Behavior, Animal; Central Nervous System Sensitization; Disease Models, Animal; Glutamate-Ammonia Ligase; Male; Medulla Oblongata; Methionine Sulfoximine; Nociceptors; Pain Measurement; Posterior Horn Cells; Pulpitis; Rats; Rats, Sprague-Dawley; Reflex | 2011 |
A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure.
Topics: Animals; Apoptosis; Cells, Cultured; Cytokines; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Galactosamine; Glutamate-Ammonia Ligase; Inflammation Mediators; Interferon-gamma; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophages, Peritoneal; Male; Methionine Sulfoximine; Mice; STAT1 Transcription Factor; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Downregulation of glutamine synthetase via GLAST suppression induces retinal axonal swelling in a rat ex vivo hydrostatic pressure model.
Topics: Animals; Aspartic Acid; Axons; Blotting, Western; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 1; Fluorescent Antibody Technique, Indirect; Glutamate-Ammonia Ligase; Glutamic Acid; Hydrostatic Pressure; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain Waves; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Male; Methionine Sulfoximine; Microscopy, Immunoelectron; Rats; Rats, Sprague-Dawley | 2012 |
Effect of sex on lifespan, disease progression, and the response to methionine sulfoximine in the SOD1 G93A mouse model for ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Female; Glutamate-Ammonia Ligase; Kaplan-Meier Estimate; Longevity; Male; Methionine Sulfoximine; Mice; Mice, Transgenic; Muscle, Skeletal; Orchiectomy; Ovariectomy; Sex Factors; Superoxide Dismutase; Time Factors | 2012 |
Monoamines and glycogen levels in cerebral cortices of fast and slow methionine sulfoximine-inbred mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain; Disease Models, Animal; Glycogen; Hydroxyindoleacetic Acid; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Seizures; Serotonin; Thiophenes | 2013 |
Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo.
Topics: Animals; Anti-Bacterial Agents; Antitubercular Agents; Colony Count, Microbial; Disease Models, Animal; Drug Synergism; Glutamate-Ammonia Ligase; Guinea Pigs; Humans; Isoniazid; Lung; Methionine Sulfoximine; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Spleen; Tuberculosis, Pulmonary | 2003 |
Characterization of benzo[a]pyrene quinone-induced toxicity to primary cultured bone marrow stromal cells from DBA/2 mice: potential role of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Anemia, Aplastic; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Benzo(a)pyrene; Benzopyrenes; Bone Marrow; Bone Marrow Cells; Buthionine Sulfoximine; Cell Survival; Cells, Cultured; Dicumarol; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Leukemia, Experimental; Male; Methionine Sulfoximine; Mice; Mice, Inbred DBA; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Quinones; Stromal Cells; Superoxide Dismutase; Thiones; Thiophenes | 1995 |
A protective effect of glutathione-dextran macromolecular conjugates on acetaminophen-induced hepatotoxicity dependent on molecular size.
Topics: Acetaminophen; Animals; Antimetabolites; Aspartate Aminotransferases; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Chromatography, Gel; Chromatography, High Pressure Liquid; Cyanogen Bromide; Delayed-Action Preparations; Dextrans; Disease Models, Animal; Drug Delivery Systems; Glutathione; In Vitro Techniques; Injections, Intravenous; Liver; Liver Diseases; Male; Methionine Sulfoximine; Mice; Molecular Weight; Survival Rate | 1994 |
Esophagitis in Sprague-Dawley rats is mediated by free radicals.
Topics: Animals; Buthionine Sulfoximine; Disease Models, Animal; Drug Evaluation, Preclinical; Esophagitis, Peptic; Esophagus; Free Radical Scavengers; Free Radicals; Glutamate-Cysteine Ligase; Glutathione; Linear Models; Male; Methionine Sulfoximine; Mucous Membrane; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Superoxide Dismutase; Time Factors | 1995 |
A model for fatal halothane hepatitis in the guinea pig.
Topics: Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Glutathione; Guinea Pigs; Halothane; Liver; Male; Methionine Sulfoximine; Necrosis | 1994 |
Attempts to produce spike-and-wave complexes in the electrocorticogram of the rat.
Topics: Animals; Cerebral Cortex; Cobalt; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Estrogens, Conjugated (USP); Fluoroacetates; Male; Methionine Sulfoximine; Pentylenetetrazole; Picrotoxin; Rats; Seizures | 1975 |
[Alterations in phosphatidylcholine and phospholipase A2 of the renal tissue in gentamicin nephrotoxicity: comparative study with buthionine sulfoximine administered model].
Topics: Acute Kidney Injury; Animals; Buthionine Sulfoximine; Disease Models, Animal; Gentamicins; Glutathione; Kidney; Lipid Peroxidation; Male; Methionine Sulfoximine; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley | 1992 |
Hydrogen peroxide as a mediator of programmed cell death in the blastocyst.
Topics: Animals; Antimetabolites; Blastocyst; Buthionine Sulfoximine; Catalase; Cell Survival; Disease Models, Animal; Glutathione; Hydrogen Peroxide; In Vitro Techniques; Methionine Sulfoximine; Mice; Neoplasms, Germ Cell and Embryonal; Tumor Cells, Cultured | 1991 |
Anticataractogenic property of gamma-glutamylcysteine ethyl ester in an animal model of cataract.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cataract; Dipeptides; Disease Models, Animal; Glutathione; Kidney; Lens, Crystalline; Liver; Male; Methionine Sulfoximine; Organ Culture Techniques; Rats; Rats, Inbred Strains | 1991 |
DNA synthesis in Alzheimer type II astrocytosis. The question of astrocytic proliferation and mitosis in experimentally induced hepatic encephalopathy.
Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Cell Division; Disease Models, Animal; DNA Replication; Hepatic Encephalopathy; Intestine, Large; Male; Methionine Sulfoximine; Mitosis; Rats; Rats, Inbred Strains; Reference Values; Spleen | 1989 |
Induction of hepatic veno-occlusive disease in dogs.
Topics: Animals; Busulfan; Buthionine Sulfoximine; Cyclophosphamide; Disease Models, Animal; Dog Diseases; Dogs; Hepatic Veno-Occlusive Disease; Liver; Melphalan; Methionine Sulfoximine; Methotrexate; Monocrotaline; Pyrrolizidine Alkaloids; Radiation Injuries, Experimental; Radiography | 1987 |
Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice.
Topics: Age Factors; Animals; Buthionine Sulfoximine; Cataract; Disease Models, Animal; Glutathione; Humans; Kidney; Lens, Crystalline; Liver; Male; Methionine Sulfoximine; Mice; Testis | 1986 |
Studies on neurochemical changes in experimental epilepsy.
Topics: Allyl Compounds; Aminobutyrates; Animals; Biogenic Amines; Brain Chemistry; Carboxy-Lyases; Cerebral Cortex; Disease Models, Animal; Methionine Sulfoximine; Microscopy, Electron; Pentylenetetrazole; Rats; Seizures | 1971 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |