Page last updated: 2024-08-17

methionine and Liver Steatosis

methionine has been researched along with Liver Steatosis in 340 studies

Research

Studies (340)

TimeframeStudies, this research(%)All Research%
pre-199088 (25.88)18.7374
1990's10 (2.94)18.2507
2000's93 (27.35)29.6817
2010's135 (39.71)24.3611
2020's14 (4.12)2.80

Authors

AuthorsStudies
Ballentine, SJ; Brunt, EM; Davidson, NO; Molitor, EA; Newberry, EP; Soleymanjahi, S; Xie, Y1
Chen, C; Chen, J; Clayton, YD; Ding, WX; Du, Y; Friedman, JE; Gu, L; Gunewardena, S; Hasan, MN; Li, T; Lu, SC; Matye, D; Wang, H; Wang, Y1
Arshad, U; Husnain, A; Perdomo, MC; Poindexter, MB; Santos, JEP; Zimpel, R1
Kuttner, CS; Lammert, F; Mancina, R; Stokes, CS; Wagenpfeil, G1
Claudel, T; Fuchs, CD; Krivanec, S; Marschall, HU; Mlitz, V; Scharnagl, H; Stahlman, M; Steinacher, D; Stojakovic, T; Trauner, M; Wahlström, A1
da Silva, RP; Eudy, BJ; Fernandez, G; Lai, J; Mathews, CE; McDermott, CE1
Andreola, F; Argemi, J; Bataller, R; Caballeria, J; Cowart, LA; De Chiara, F; Fondevila, C; Fox, T; Frenguelli, L; Kester, M; Levi, A; Longato, L; Luong, TV; Massey, V; Mazza, G; Montefusco, D; Omenetti, S; Pinzani, M; Rombouts, K; Shanmugavelandy, SS; Zanieri, F1
Balint-Lahat, N; Ben-Ari, Z; Brzezinski, RY; Finchelman, JM; Grossman, E; Hoffer, O; Leor, J; Levin-Kotler, L; Lewis, N; Naftali-Shani, N; Ovadia-Blechman, Z; Rabin, N; Safran, M; Sternfeld, A; Tepper-Shaihov, O; Unis, R; Zimmer, Y1
Andriamihaja, M; Blachier, F; Blais, A1
Abe, A; Miyajima, K; Nakae, D; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M1
Chen, Y; Liu, Y; Qian, K; Xiong, Y; Xu, W; Zhai, T1
Ceacero-Heras, D; Córdova, S; de Medina, FS; Gámez-Belmonte, R; Hernández-Chirlaque, C; Martínez-Augustin, O; Tena-Garitaonaindia, M1
Chen, Y; Cheng, Y; Ding, W; Fan, J; Jiang, D; Lin, S; Pan, J; Zhang, J1
Baek, J; Basavarajappa, L; Hoyt, K; Parker, KJ; Poul, SS; Reddy, S; Tai, H1
Berardo, C; Cagna, M; Croce, AC; Di Pasqua, LG; Ferrigno, A; Mannucci, B; Milanesi, G; Vairetti, M1
Abe, M; Akiba, J; Hisamoto, T; Ikezono, Y; Iwamoto, H; Koga, H; Matsui, T; Nakamura, K; Nakamura, T; Torimura, T; Wada, F; Yamagishi, SI; Yoshida, T1
Cohen, DE; Hornick, JL; Nicholls, HT1
Chen, Y; Cho, GJ; Chung, HT; Joe, Y; Kim, HJ; Kim, J; Kim, SK; Kim, UH; Park, J; Park, SU; Ryter, SW; Ryu, J; Surh, YJ1
Baron, JL; Duwaerts, CC; Goodsell, A; Maher, JJ; Mattis, AN; Pierce, AA; Siao, K1
Bekpınar, S; Çevik, A; Genc, S; Gürdöl, F; Küskü-Kiraz, Z; Olgaç, V; Ünlücerci, Y; Uysal, M1
Adam, AC; Bock, C; Dahl, JA; Espe, M; Fernandes, JMO; Jakt, LM; Klughammer, J; Skjærven, KH1
Hasegawa, K; Itoh, H; Kanda, T; Kawabe, H; Kitahama, R; Komatsu, M; Kurokochi, A; Ono, T; Shigaki, S; Tokuyama, H; Urai, H; Wakino, S; Yukioka, H1
Bao, L; Chen, Z; Ding, G; Guo, M; Guo, W; Liu, F; Zhan, Y; Zhang, M; Zhao, Y; Zheng, N1
Hamaguchi, T; Horibe, S; Kawauchi, S; Mizuno, S; Rikitake, Y; Sasaki, N; Tanahashi, T1
Bader, BL; Dahlhoff, C; Daniel, H; Desmarchelier, C; Fürst, RW; Geisel, J; Haag, A; Hummel, B; Obeid, R; Sailer, M; Ulbrich, SE1
He, J; Hu, B; Huang, M; Kelley, EE; Lu, P; Shi, X; Weidert, ER; Xie, W; Xu, M1
Berneman, Z; Boeykens, N; De Greef, K; Ponsaerts, P; Van der Linden, A; Ysebaert, D1
Ables, GP; Caliendo, NS; Malloy, VL; Mattocks, DA; Orentreich, DS; Orentreich, N; Perrone, CE1
Choi, MK; Han, JM; Kim, HG; Lee, HW; Lee, JS; Park, HJ; Son, CG1
Baghdasaryan, A; Claudel, T; Das, SK; Halilbasic, E; Hoefler, G; Jha, P; Lass, A; Mueller, M; Trauner, M; Zechner, R; Zimmermann, R1
Obeid, R1
Chen, J; Chen, W; Deng, T; Lin, J; Qiu, L; Shi, D; Yang, J; Yang, JY; Ying, M1
Asahara, T; Asano, T; Chonan, O; Fujishiro, M; Fukushima, T; Iwashita, M; Kamata, H; Kushiyama, A; Matsunaga, Y; Nakatsu, Y; Nishimura, F; Okubo, H; Sakoda, H; Yoshida, Y1
Cheng, L; Dai, RW; Luo, ZL; Ren, JD; Tang, LJ; Tian, FZ; Wang, T; Xiang, K1
Fujino, M; Kawai, K; Li, XK; Luo, XY; Nakae, S; Sugiyama, T; Takahara, T; Tsukada, K; Tsuneyama, K; Zhong, L1
Aibara, D; Gonzalez, FJ; Matsuo, K; Matsusue, K; Takiguchi, S; Yamano, S1
Chan, CC; Hsieh, YC; Huang, YH; Lee, KC; Lin, HC; Yang, YY1
Ezaki, T; Itagaki, H; Morikawa, S; Ogawa, K; Shimizu, K1
de Luka, S; Ethuričić, I; Jorgačević, B; Mladenović, D; Ninković, M; Radosavljević, TS; Sobajić, S; Stanković, MN; Vukicevic, RJ1
Hatano, E; Koyama, Y; Nakamura, K; Seo, S; Takemoto, K; Tanabe, K; Taura, K; Toriguchi, K; Uemoto, S1
Rezazadeh, A; Yazdanparast, R1
Canet, MJ; Cherrington, NJ; Clarke, JD; Dzierlenga, AL; Hardwick, RN; Lake, AD1
Burrington, CM; Chowdhry, S; Davenport, SK; Greene, MW; Horsman, MJ; Johnson, AK; Lynch, DT; Sparks, JD; Tirrell, PC; Zhang, J1
Aleksić, V; Duričić, I; Ješić-Vukićević, R; Jorgačević, B; Mladenović, DR; Radosavljević, TS; Šobajić, SS; Stanković, MN; Timić, J; Vučević, DB1
Claudel, T; Hoefler, G; Jha, P; Knopf, A; Koefeler, H; Lackner, C; Mueller, M; Trauner, M1
Albano, E; Bena, S; Bozzola, C; Bugianesi, E; Jindal, A; Kusters, D; Locatelli, I; McArthur, S; Parola, M; Paternostro, C; Perretti, M; Reutelingsperger, C; Sutti, S; Vacchiano, M1
Baud, V; Billot, K; Collin de l'Hortet, A; Fauveau, V; Gilgenkrantz, H; Guidotti, JE; Helmy, N; Prip-Buus, C; Vons, C; Zerrad-Saadi, A; Ziol, M1
Chen, S; Gu, J; Ji, L; Liu, X; Peng, X; Shen, X; Wu, W; Xue, R; Zhang, S1
Berk, M; Dixon, L; Feldstein, AE; Inzaugarat, ME; Papouchado, BG; Povero, D; Thapaliya, S; Wree, A1
Choi, YK; Jang, BK; Jung, GS; Jung, YA; Kim, HS; Kim, JG; Kim, MK; Lee, IK; Park, KG; Seo, HY1
Azuma, T; Hoshi, N; Kawano, Y; Minami, A; Nishiumi, S; Terashima, Y; Yoshida, M1
Cho, EJ; Jang, ES; Kim, CY; Kim, YJ; Kwak, MS; Lee, HS; Lee, JH; Yoon, JH; Yu, SJ1
Kim, YS; Koo, BA; Lee, HS; Ryu, JE; Son, WC1
Toohey, JI1
Guo, H; Jiang, X; Ling, W; Shen, T; Sun, X; Tang, X; Xia, M1
Chang, CJ; Liou, SS; Liu, IM; Tzeng, TF1
Kobayashi, Y; Nohara, K; Okamura, K; Sano, T; Takumi, S; Yanagisawa, H1
Akimoto, T; Alam, MM; Goto, M; Haseba, T; Kitamura, H; Motohashi, H; Ota, N; Shimizu, A; Takano-Yamamoto, T; Yamamoto, M1
Aube, C; Bazeries, P; Boursier, J; Chaigneau, J; Ducluzeau, PH; Fizanne, L; Flamment, M; Leiber, LM; Michalak, S; Moal, V; Roullier, V; Roux, J1
Bala, S; Catalano, D; Csak, T; Iracheta-Vellve, A; Kodys, K; Lippai, D; Szabo, G1
Aldámiz-Echevarría, L; Andrade, F; Aspichueta, P; Barbier-Torres, L; Beraza, N; Falcon-Perez, JM; Fernandez, ML; Fernández-Ramos, D; Fernandez-Tussy, P; García-Monzón, C; García-Rodríguez, JL; Juan, VG; Lage-Medina, S; Lopitz-Otsoa, F; Lu, SC; Luka, Z; Martínez-Chantar, ML; Martínez-Lopez, N; Martínez-Uña, M; Mato, JM; Varela-Rey, M; Wagner, C; Woodhoo, A; Zubiete-Franco, I1
Bertone, V; Boncompagni, E; Ferrigno, A; Freitas, I; Gruppi, C; Milanesi, G; Tarantola, E; Tira, ME; Vaccarone, R; Vairetti, M1
Chmiel, KJ; Halsted, CH; Kharbanda, KK; Kim, K; Medici, V; Olson, K; Rutledge, JC; Shibata, NM; Su, RJ; Syed, R; Yokoyama, A1
Ai, D; He, J; Jiang, C; Liu, W; Liu, Y; Peng, L; Wang, C; Yao, L; Zhang, X; Zhu, Y1
Harimoto, N; Ikegami, T; Itoh, S; Kimura, K; Maehara, Y; Okano, S; Shirabe, K; Takeishi, K; Uchiyama, H; Yoshizumi, T1
Berardo, C; Croce, AC; Di Pasqua, LG; Ferrigno, A; Richelmi, P; Rizzo, V; Vairetti, M1
Cai, D; Hu, Y; Idriss, AA; Jia, Y; Liu, J; Omer, NA; Sun, Q; Zhao, R1
Hennig, B; Hoffman, JB; Perkins, JT; Petriello, MC; Stromberg, AJ; Wahlang, B1
Harada, S; Kim, KI; Kim, SK; Kim, SR; Miyagi, K; Morimoto, Y; Nakamoto, K; Obata, T; Tokuyama, S1
Bian, Y; Fang, M; Li, L; Shao, J; Xu, H; Xu, Y; Yang, L1
Bell-Anderson, KS; Farrell, GC; Larter, CZ; Williams, J; Yeh, MM1
Akahori, H; Ando, H; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa-Nagata, N; Misu, H; Nabemoto, S; Nakanuma, Y; Ota, T; Takamura, T; Uno, M; Zen, Y1
Baéza, E; Bauchart, D; Davail, S; Durand, D; Gruffat, D; Saez, G2
Akao, M; Hibi, T; Irie, R; Miyashita, K; Mizutani, A; Noguchi, M; Ohkura, T; Oike, Y; Sumimoto, H; Suzuki, T; Tabata, M; Taguchi, T; Takayanagi, A; Tamiya, G; Teratani, T; Tomita, K; Yokoyama, H1
Larter, CZ; Yeh, MM1
Dolganiuc, A; Ellis, M; Kodys, K; Mandrekar, P; Petrasek, J; Szabo, G; Velayudham, A1
Berk, M; Feldstein, AE; Li, ZZ; McIntyre, TM1
Aeed, H; Avni, Y; Ilan, Y; Shahmurov, M; Shalev, T; Shirin, H; Sorin, V; Stavinski, S1
Abarca-Quinones, J; Brichard, S; Da Silva Morais, A; Guigas, B; Hue, L; Lebrun, V; Leclercq, IA; Viollet, B1
Blair, IA; Gong, W; Huang, Y; Lorent, K; Mañoral-Mobias, R; Matthews, RP; Murray, IV; Pack, M1
Brooling, J; dela Pena, A; Farrell, GC; Francisco, R; Hou, JY; Larter, CZ; Osvath, SR; Sedger, LM; Teoh, N; Williams, J; Yeh, MM; Zhang, RH1
Beysen, C; Grenert, JP; Maher, JJ; Ng, RK; Ogata, H; Pickens, MK; Turner, SM; Yan, JS1
Kalhan, SC1
Kanayama, M; Kawai, K; Kudo, H; Mann, DA; Morita, S; Nakayama, Y; Oya, T; Sasahara, M; Sugiyama, T; Takahara, T; Yata, Y1
Bagnyukova, TV; Beland, FA; Latendresse, JR; Melnyk, S; Montgomery, B; Pogribny, IP; Ross, SA; Rusyn, I; Tryndyak, VP1
Harnish, DC; Liu, Q; Wang, J; Zhang, S1
Akin, H; Atug, O; Avsar, E; Celikel, C; Eren, F; Imeryuz, N; Ozdogan, O; Ozguner, F; Tahan, G; Tahan, V; Tarcin, O; Tozun, N; Uzun, H1
Miyazaki, H; Takitani, K; Tamai, H; Yoden, A1
Catalano, D; Dolganiuc, A; Kodys, K; Mandrekar, P; Petrasek, J; Szabo, G; Velayudham, A1
Abdelmalek, M; Choi, SS; Conde-Vancells, J; Diehl, AM; Fearing, CM; Guy, CD; Jung, Y; Karaca, GF; Omenetti, A; Pereira, TA; Syn, WK; Teaberry, V; Wang, J; Witek, RP; Yang, L1
Amini, R; Molaei, M; Nosrati, N; Yazdanparast, R1
Agboola, KM; Charlton, P; Choi, SS; Diehl, AM; Guy, CD; Jung, Y; Karaca, FG; Omenetti, A; Pereira, TA; Pollard, J; Stone, WC; Syn, WK; Teaberry, V; Witek, RP1
Elias, MS; Green, RM; Henkel, AS1
Ahsan, MK; Hoshino, Y; Masutani, H; Nakamura, H; Oka, S; Okuyama, H; Yodoi, J1
Chan, HL; Chu, ES; Farrell, GC; Sung, JJ; Wang, R; Wang, S; Wong, VW; Wu, CW; Yu, J1
Arena, U; Caligiuri, A; Delogu, W; Galastri, S; Laffi, G; Marra, F; Milani, S; Novo, E; Parola, M; Pinzani, M; Provenzano, A; Vizzutti, F; Zamara, E1
Ashford, ML; Chowdhry, S; Dillon, JF; Dinkova-Kostova, AT; Hayes, JD; Meakin, PJ; Nazmy, MH; Tsujita, T; Walsh, SV1
Hyodo, I; Ishige, K; Ishii, T; Nakahara, A; Okada, K; Shoda, J; Sugimoto, H; Taguchi, K; Ueda, T; Warabi, E; Yamamoto, M; Yanagawa, T1
Carpentier, S; Danjoux, M; Garcia, V; Levade, T; Mas, E; Ségui, B2
Kawada, N; Mu, YP; Ogawa, T1
Guo, GL; Luyendyk, JP; Sullivan, BP; Wang, R1
Apte, U; Behari, J; Cieply, B; Evans, R; Hauth, B; Krauland, L; Monga, SP; Otruba, W; Wu, T; Yeh, TH1
Du, ZY; El-Mowafi, A; Espe, M; Liaset, B; Rathore, RM1
Gentile, CL; Nivala, AM; Pagliassotti, MJ; Pfaffenbach, KT; Wang, D; Wei, Y1
Chen, XR; Kwada, N; Mu, YP; Ogawa, T; Xi, XH1
Chang, SI; Chen, TC; Hsiao, IT; Lin, KJ; Yeh, TS; Yen, TC1
Chen, XR; Mu, YP; Xi, XH1
Klaassen, CD; Tanaka, Y; Yeager, RL; Zhang, YK1
Fujii, H; Itoh, Y; Niimi, T; Nishimura, T; Okanoue, T; Yamaguchi, K; Yokomizo, C; Yoshikawa, T1
Cheng, AS; Chu, ES; Lam, CN; Lee, CW; Sung, JJ; Wong, VW; Wu, CW; Yu, J1
Caballeria, J; Caballero, F; Elena, M; Fernández, A; Fernández-Checa, JC; Fucho, R; García-Ruiz, C; Martínez, L; Matías, N; Morales, A1
Galle, PR; Schattenberg, JM1
Adegboyega, P; Allman, M; Brady, K; Gaskin, L; Pang, J; Pruitt, K; Rivera, CA1
Adams, DH; Choi, SS; Diehl, AM; Fearing, CM; Guy, CD; Jung, Y; Karaca, GF; Omenetti, A; Oo, YH; Pereira, FE; Pereira, TA; Syn, WK; Teaberry, V; Witek, RP1
Grenert, JP; Maher, JJ; Ogata, H; Pickens, MK; Soon, RK1
Bammler, TK; Beyer, RP; Botta, D; Campbell, JS; Fausto, N; Haque, JA; Kavanagh, TJ; McMahan, RS; Montine, TJ; Shimizu-Albergine, M; Wilson, AM; Yeh, MM1
Anstee, QM; Charlton, P; Concas, D; Goldin, RD; Kudo, H; Levene, A; Pollard, J; Thomas, HC; Thursz, MR1
Grenert, JP; Maher, JJ; Soon, RK; Yan, JS1
Guo, GL; Kassel, KM; Luyendyk, JP; Tawfik, O1
Harada, T; Imada, K; Kajikawa, S; Kawashima, A; Mizuguchi, K; Shimizu, Y; Takeuchi, T1
Fu, MM; Sun, R; Tian, ZG; Wei, HM1
Abdelmalek, MF; Adams, DH; Agboola, KM; Bhattacharya, SD; Chen, Y; Choi, SS; Diehl, AM; Guy, CD; Jung, Y; Karaca, GF; Kuo, PC; Liaskou, E; Malladi, P; Mi, Z; Michelotti, GA; Moylan, C; Omenetti, A; Oo, YH; Pereira, TA; Syn, WK; Teaberry, V; Whitington, PF; Zdanowicz, M1
Han, F; Kong, LB; Nan, YM; Wang, RQ; Wu, WJ; Yu, J; Zhao, SX1
Fu, N; Han, F; Kong, L; Nan, Y; Wang, R; Wu, WJ; Yu, J; Zhao, S1
CHAIKOFF, IL; ENTENMAN, C; MONTGOMERY, ML1
Aghazadeh, S; Amini, R; Ghaffari, SH; Yazdanparast, R1
Andrew, R; Aucott, RL; Iredale, JP; Livingstone, DE; Macfarlane, DP; Morton, NM; Nyirenda, MJ; Walker, BR; Zou, X1
Horiguchi, N; Kakizaki, S; Mori, M; Takizawa, D; Tojima, H; Yamazaki, Y1
Catalano, D; Csak, T; Dolganiuc, A; Hritz, I; Kurt-Jones, E; Levin, I; Lippai, D; Mandrekar, P; Petrasek, J; Szabo, G; Velayudham, A1
Heger, M; Kloek, JJ; Marsman, HA; Nederveen, AJ; Nienhuis, SL; Stoker, J; Ten Kate, FJ; van Gulik, TM; van Werven, JR1
Lu, SC; Mato, JM1
Bachmair, EM; Boekschoten, MV; Brennan, L; Coort, SL; Daniel, H; Evelo, C; Gibney, MJ; Keijer, J; Kleemann, R; McLoughlin, GA; Muller, M; Roos, Bd; Rubio-Aliaga, I; Sailer, M; van Erk, M; van Schothorst, EM1
Han, F; Kong, L; Kong, LB; Nan, YM; Wang, RQ; Wu, WJ; Yu, J; Zhao, SX1
Fujii, H; Itoh, Y; Niimi, T; Nishimura, T; Okanoue, T; Umemura, A; Yamaguchi, K; Yokomizo, C; Yoshikawa, T1
Bala, S; Csak, T; Dolganiuc, A; Kodys, K; Lippai, D; Nath, B; Petrasek, J; Szabo, G1
Bennett, C; Dasarathy, S; Duenas, C; Edmison, J; Gruca, LL; Kalhan, SC; Lopez, R; Marczewski, S1
Csak, T; Dolganiuc, A; Ganz, M; Kodys, K; Pespisa, J; Szabo, G1
Clarke, CN; Edwards, MJ; Lentsch, AB; Schuster, R; Tevar, AD; Wang, J1
Elias, M; Gardikiotes, K; Gottstein, J; Green, RM; Rinella, ME; Siddiqui, MS1
Banasch, M; Ellrichmann, M; Goetze, O; Schmidt, WE; Tannapfel, A1
Heger, M; Kloek, JJ; Marsman, HA; Nienhuis, SL; ten Kate, FJ; van Gulik, TM1
Dilger, RN; Garrow, TA; Gupta, S; Kruger, WD; Li, L; Strakova, J; Tryon, K1
Katsuya, T; Kiomy Osako, M; Koriyama, H; Kyutoku, M; Minobe, N; Miyake, T; Morishita, R; Moritani, T; Nakagami, F; Nakagami, H; Shimamura, M; Shimizu, H; Shimosato, T1
Miyahara, T; Miyata, Y; Moriyasu, F1
Cho, MS; Jang, JE; Jeon, BH; Koh, EH; Lee, KU; Leem, J; Park, HS; Park, IS; Woo, SH1
Bonora-Centelles, A; Castell, JV; José Gómez-Lechón, M; López, S; Negro, A; Pareja, E; Teresa Donato, M; Tolosa, L1
Cho, WK; Choi, HS; Hahm, JS; Jang, KS; Jeon, HJ; Jun, DW; Jun, JH; Kim, HJ; Kwon, HJ; Lee, HL; Lee, KN; Lee, MH; Lee, OY; Yoon, BC1
Brückner, S; Christ, B; Pelz, S; Stock, P1
Canet, MJ; Cherrington, NJ; Fisher, CD; Hardwick, RN; Street, SM1
Bauer, S; Buechler, C; Eisinger, K; Hellerbrand, C; Higuchi, A; Schäffler, A; Walsh, K; Walter, R; Wanninger, J; Weiss, TS1
Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY1
Bucchieri, F; Bugianesi, E; Galvano, F; Li Volti, G; Mangiameli, A; Marino Gammazza, A; Marino, A; Parola, M; Paternostro, C; Salamone, F; Tibullo, D1
Gonzalez, FJ; Krausz, KW; Matsubara, T; Patterson, AD; Tanaka, N1
Camporez, JP; Eisenbarth, SC; Elinav, E; Flavell, RA; Gordon, JI; Hao, L; Henao-Mejia, J; Hoffman, HM; Jin, C; Jurczak, MJ; Kau, AL; Mehal, WZ; Shulman, GI; Strowig, T; Thaiss, CA1
Cha, BS; Chae, MK; Kang, ES; Lee, BW; Lee, HC; Park, SG; Song, SO1
Catalán, V; Frühbeck, G; Gómez-Ambrosi, J; Oliver, J; Roca, P; Rodríguez, A; Rotellar, F; Salvador, J; Silva, C; Valentí, V; Valle, A1
Harada, N; Hashimoto, E; Horie, M; Ishii, T; Itoh, K; Okada, K; Shoda, J; Sugimoto, H; Taguchi, K; Tokushige, K; Ueda, T; Utsunomiya, H; Warabi, E; Yamamoto, M1
Molaei, M; Rezazadeh, A; Yazdanparast, R1
Berk, M; Dixon, LJ; Feldstein, AE; Papouchado, BG; Thapaliya, S1
Kwada, N; Mu, YP; Ogawa, T1
Anderson, KA; Dewey, AM; Green, RM; Henkel, AS; Olivares, S1
Barbagallo, I; Cappello, F; Galvano, F; Li Volti, G; Mangiameli, A; Salamone, F1
Ebinuma, H; Hatsuse, K; Hibi, T; Hokari, R; Irie, R; Kanai, T; Kurihara, C; Mataki, N; Minamino, T; Miura, S; Nishiyama, K; Okada, Y; Oshikawa, T; Saito, H; Shimamura, K; Shimizu, I; Sugiyama, K; Suzuki, T; Teratani, T; Tomita, K; Yamamoto, J; Yokoyama, H; Yoshida, Y1
Conde de la Rosa, L; Fernandez, A; Fernandez-Checa, JC; Fucho, R; Garcia-Ruiz, C; Kaplowitz, N; Machida, K; Mansouri, A; Martinez-Chantar, ML; Matias, N; Mato, JM; Murphy, MP; Tsukamoto, H; von Montfort, C1
Canet, MJ; Cherrington, NJ; Gandolfi, AJ; Hardwick, RN; Klimecki, WT; Kopplin, MJ; Lake, AD; Scheffer, GL1
Hou, MC; Huang, YT; Lee, FY; Lee, SD; Lin, HC; Tsai, TH; Yang, YY1
Battle, M; Doddapattar, P; Hoefler, G; Kratky, D; Levak-Frank, S; Obrowsky, S; Patankar, JV1
Barakat, HA; Hamza, AH1
González-Gallego, J; Marcolin, E; Marroni, N; San-Miguel, B; Tieppo, J; Tuñón, MJ; Vallejo, D1
Bigaud, E; Corrales, FJ; He, B; O'Malley, BW; Prieto, J; Sánchez-Quiles, V; Santamaría, E; Segura, V1
Hahn, YS; Landes, SG; Nguyen, V; Novobrantseva, TI; Tosello-Trampont, AC1
Davaatseren, M; Hur, HJ; Hwang, JT; Kim, HJ; Kim, MJ; Kim, MS; Kwon, DY; Park, JH; Sung, MJ; Yang, HJ1
Carmeliet, P; Casteleyn, C; Colle, I; Coulon, S; Geerts, A; Heindryckx, F; Jonckx, B; Leclercq, I; Legry, V; Libbrecht, L; Olievier, K; Stassen, JM; Van Steenkiste, C; Van Vlierberghe, H1
Hada, N; Ito, T; Katsume, A; Matsumoto, M; Sakamaki, Y; Shiga, T; Sudoh, M; Tanaka, C; Uno, A1
Bassani, VL; Borghetti, GS; Forgiarini, LF; Marcolin, E; Marroni, NP; Picada, JN; Rodrigues, G; Tieppo, J1
Farrell, GC; Hall, P; Ip, E; Kirsch, R; Leclercq, I; Robertson, G1
SHILS, ME; STEWART, WB1
VENTURI, VM1
JANSEN, L1
BECCARI, E; GARESIO, T1
MENGHINI, G1
CORNATZER, WE; SNYDER, F1
FARBER, E; SIDRANSKY, H1
BEST, CH; LUCAS, CC; WILGRAM, GF1
KRIKELIS, J; MARGARONIS, K; TSAMBOULAS, N1
CORNATZER, WE; SNYDER, F; SYNDER, C1
METAIS, P; SACREZ, A; SCHIRARDIN, H; WARTER, J1
METAIS, P; SACREZ, A; WARTER, J; WERYHA, A1
SRIRAMACHARI, S1
SKALKA, M1
JASIK, AD; WILLIAMS, JN1
HUTTERER, F1
SOKOLOVSKAIA, IaI1
FINKELSTEIN, JD; IRREVERRE, F; LASTER, L; MUDD, SH1
NOMURA, T2
REVELLI, M1
KENNEDY, JS; PATRICK, RS1
FARBER, E; LOMBARDI, B; SHULL, KH; THOMAS, M; VILLA-TREVINO, S1
SUEYOSHI, Y; TOKUDA, R1
COOK, CR; LYMAN, RL; THENEN, S1
Hurlebaus, AJ; Williams, JN1
CARSON, NA; DENT, CE; FIELD, CM; GAULL, GE1
KOWALEWSKI, K1
INOUE, K1
RADOMSKI, MW; WOOD, JD1
GEER, BW; VOVIS, GF1
DE GIOVANNI, R; SHILS, ME; STEWART, WB1
KAWAKAMI, T; TOKUDA, R1
Clarkson, V; Hall, Pde L; Jaffer, MA; Kirsch, R; Kirsch, RE; Marais, DA; Shephard, EG; Woodburne, VE1
Farrell, G; George, J; Leclercq, I; Pera, N; Phung, N; Yun Hou, J1
Green, RM; Rinella, ME1
Kashireddy, PR; Rao, MS1
BENARD, H; GAJDOS, A1
Green, RM; Malladi, P; Melin-Aldana, H; Sahai, A; Whitington, PF1
Green, RM; Malladi, P; Melin-Aldana, H; Pan, X; Paul, R; Sahai, A; Whitington, PF1
Farrell, GC; Ito, Y; McCuskey, MK; McCuskey, RS; Perry, M; Robertson, GR1
HARTMANN, F; LEUSCHNER, F1
Green, RM; Koppe, SW; Malladi, P; Sahai, A; Whitington, PF1
dela Peña, A; Farrell, GC; Horsmans, Y; Leclercq, IA; Sempoux, C1
Czaja, MJ; Rigoli, RM; Schattenberg, JM; Singh, R; Wang, Y1
Green, RM; Sundaram, SS; Whitington, PF1
Barak, AJ; Beckenhauer, HC; Kharbanda, KK; Mailliard, ME; Rogers, DD; Siford, GL; Sorrell, MF; Tuma, DJ1
Ando, S; Chiyo, T; Han, JY; Hibi, T; Horie, Y; Ishii, H; Kaneko, T; Kato, S; Kitamura, N; Kumagai, N; Makino, S; Mizutani, A; Nagata, H; Ohkura, T; Ohsumi, K; Oike, Y; Saito, H; Shimoda, M; Tamiya, G; Toda, K; Tomita, K; Tomizawa, M1
Brown, JL; Hirose, R; Jackman, M; Liu, T; Maher, JJ; Niemann, CU; Roberts, JP; Serkova, NJ1
Dela Peña, A; Farrell, G; Field, J; George, J; Jones, B; Leclercq, I1
Czaja, MJ; Lefkowitch, JH; Rigoli, RM; Schattenberg, JM; Scherer, PE; Singh, R; Wang, Y1
Green, RM; Igolnikov, AC1
Kohli, R; Malladi, P; Pan, X; Paul, R; Sahai, A; Whitington, PF1
Chen, TS; de Villiers, WJ; Im, HJ; McClain, CJ; Oz, HS1
Dela Peña, A; Farrell, GC; Hall, P; Hou, JY; Ip, E; Kirsch, R; Leclercq, I; Pera, N; Sesha, J; Yu, J1
Inada, Y; Kuroda, J; Maruyama, K; Nagasawa, T; Nakano, S; Shibata, N; Takahashi, T; Tamura, T; Yamazaki, Y1
Banerjee, R; Bauman, Z; Braun, A; Lu, SC; Prudova, A; Vitvitsky, V1
Clarkson, V; de la M Hall, P; Kirsch, R; Marais, AD; Ryffel, B; Shephard, EG; Verdonk, RC1
Horiguchi, N; Kakizaki, S; Mori, M; Negishi, M; Sato, K; Sohara, N; Takagi, H; Yamazaki, Y1
Green, RM; Igolnikov, A; Lammert, F; Rangnekar, AS1
Hall, Pde L; Kirsch, R; Marais, AD; Sijtsema, HP; Tlali, M1
dela Peña, A; Farrell, GC; Leclercq, IA; Williams, J1
Akahori, H; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa, N; Misu, H; Nakanuma, Y; Ota, T; Sakurai, M; Takamura, T; Uno, M; Zen, Y1
Li, Z; Vance, DE1
Barve, S; Cave, M; Deaciuc, I; Joshi-Barve, S; McClain, C; Mendez, C; Song, Z1
Alves, VA; Barbeiro, HV; Caldwell, SH; Carrilho, FJ; de Lima, VM; de Mello, ES; de Oliveira, CP; Sawada, LY; Soriano, FG1
Chan, HL; Cheung, KF; Chu, ES; Farrell, GC; Hui, AY; Leung, WK; Sung, JJ; Yu, J1
Akisawa, N; Dong, H; Hirose, A; Iwasaki, S; Li, C; Nozaki, Y; Onishi, S; Ono, M; Saibara, T; Takahashi, M; Wang, J1
Bessems, M; Doorschodt, BM; Kolkert, JL; van Gulik, TM; van Marle, J; van Vliet, AK; Vetelainen, RL; Vreeling, H1
Bahcecioglu, IH; Duzgun, S; Gulcu, F; Koca, S; Ozercan, IH; Sahin, K; Ustundag, B1
Friedman, JE; Janssen, RC; Jiang, H; Maclean, KN; Qadri, I; Rahman, SM; Schroeder-Gloeckler, JM1
Bhanot, S; Diehl, AM; Huang, J; Li, YX; McCall, S; Monia, BP; Pandey, SK; Yamaguchi, K; Yang, L; Yu, XX1
Akisawa, N; Hirose, A; Iwasaki, S; Masuda, K; Nozaki, Y; Oben, JA; Onishi, S; Ono, M; Saibara, T; Takahashi, M; Yoshioka, A1
Kakar, S; Lee, GS; Maher, JJ; Ng, RK; Yan, JS1
Ikejima, K; Kon, K; Okumura, K; Sato, N; Takei, Y1
Adegboyega, P; Allman, M; Rivera, CA; Tagalicud, A; van Rooijen, N; Wallace, M1
Bader, M; Clavien, PA; Dahm, F; Georgiev, P; Jang, JH; Jochum, W; Nocito, A; Renner, EL1
Aeed, H; Avni, Y; Birkenfeld, S; Bruck, R; Matas, Z; Shahmurov, M; Shirin, H1
Chen, TS; Neuman, M; Oz, HS1
Larter, CZ1
van Gulik, TM; van Vliet, A; Veteläinen, R1
Augustine, LM; Cherrington, NJ; Fisher, CD; Lickteig, AJ1
Devaraj, S; Esfandiari, F; French, SW; Halsted, CH; Villanueva, JA; White, ME1
Bell-Anderson, KS; Brown, S; Cheng, J; dela Pena, A; Farrell, GC; Larter, CZ; Williams, J; Yeh, MM1
Ichikawa, T; Kakizaki, S; Mori, M; Sato, K; Takagi, H; Takizawa, D; Yamazaki, Y1
Birkner, E; Birkner, K; Grucka-Mamczar, E; Kasperczyk, A; Kasperczyk, S; Stawiarska-Pieta, B; Zalejska-Fiolka, J1
Anan, A; Baskin-Bey, ES; Bronk, SF; Gores, GJ; Isomoto, H1
Belouze, M; Dautresme, M; Duchamp, C; Favier, R; Letexier, D; Mourier, A; Ollivier, I; Piquet, MA; Rey, B; Rigoulet, M; Romestaing, C; Rouleau, V; Servais, S; Sibille, B1
Damjanov, I; French, S; Gyamfi, MA; Wan, YJ1
Avsar, E; Celikel, C; Imeryuz, N; Tahan, V; Tozun, N1
Bahcecioglu, IH; Koca, SS; Ozercan, IH; Poyrazoglu, OK; Sahin, K; Ustundag, B1
Chan, HL; Chu, ES; Lin, G; Shen, B; Sung, JJ; Wang, S; Wong, VW; Yu, J; Zhou, X1
Borensztajn, J; Elias, MS; Fu, T; Green, RM; Rinella, ME; Smolak, RR1
Copple, BL; Gyamfi, M; He, L; Wan, YJ; Wortham, M1
Aransay, AM; Ariz, U; Calvisi, DF; Capdevila, A; Esteller, M; Fraga, M; Lu, SC; Luka, Z; Martínez, N; Martínez-Chantar, ML; Mato, JM; Matthiesen, R; Rodríguez, J; Varela, M; Vázquez-Chantada, M; Wagner, C; Yang, H1
Kumagai, N; Morinaga, S; Sugino, H; Takeuchi, O; Toda, K; Tsuchimoto, K; Tsunematsu, S; Watanabe, S1
Chan, C; Ji, C; Kaplowitz, N; Ookhtens, M; Shinohara, M; Than, TA; Vance, D1
Ando, H; Ishikura, K; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa-Nagata, N; Misu, H; Nabemoto, S; Nakanuma, Y; Ota, T; Takamura, T; Uno, M; Zen, Y1
Alexander, NM; Klatskin, G; Scheig, R1
Cardi, E; Ehrich, WE; Goldblatt, H; György, P; Hirooka, M; Langer, BW1
Egan, RF; Sidransky, H; Verney, E1
Cardi, E; György, P; Hirooka, M; Langer, BW; Rose, CS1
Noda, K; Okita, T1
Kato, T; Matsuo, T; Seri, K1
Bowers, JL; Clouse, ME; Endo, M; Hara, J; Iwai, T; Kruskal, JB; Teramoto, K1
Bowers, JL; Clouse, ME; Khettry, U; Palombo, JD; Teramoto, K1
Denda, A; Endoh, T; Horiguchi, K; Kobayashi, E; Konishi, Y; Nakae, D; Noguchi, O; Ogasawara, H; Sugimura, M; Tamura, K; Tang, Q; Tsujiuchi, T1
Baek, Y; Barama, A; Boudjema, K; Jaeck, D; Kitamura, N; Kumada, K; Nagasaki, H; Nakano, H; Suzuki, T; Tatsuno, M; Yamaguchi, M1
Fujiwara, Y; Kaneshiro, Y; Kigawa, G; Kitamura, N; Kumada, K; Kuzume, M; Matsumoto, F; Nagasaki, H; Nakano, H; Sasaki, J; Takeuchi, S; Yamaguchi, M; Yoshida, K1
Fujiwara, Y; Kigawa, G; Kitamura, N; Kumada, K; Kuzume, M; Nagasaki, H; Nakano, H; Sasaki, J; Shimura, H; Takeuchi, S; Yamaguchi, M; Yoshida, K1
Farrell, GC; Weltman, M; Zhang, BH1
Bertics, SJ; Grummer, RR1
Bell, DR; Farrell, GC; Field, J; Gonzalez, FJ; Leclercq, IA; Robertson, GR1
Aoyama, Y; Inaba, T; Yoshida, A1
Horsmans, Y; Lambotte, L; Picard, C; Saliez, A; Sempoux, C; Starkel, P; Van den Berge, V1
Aizawa, Y; Negishi, I1
Knoke, M; Lubs, H; Peters, WH; Zschiesche, M1
Andreana, A; Galletti, P; Porcelli, M; Ruggiero, G; Zappia, V1
Roberson, RH; Trujillo, T1
Leclerc, J1
Henning, SM; McKee, RW; Swendseid, ME1
Boyd, JN; Graham, ES; Graham, TC; Sherman, WK; Tennant, BC1
Hathcock, JN1
Aoyama, Y; Ashida, K; Yasui, H1
Newberne, PM; Rogers, AE1
Bannister, DW; Blair, R; Evans, AJ; Whitehead, CC2
Carbonneau, R; Demers, JM1
Gottlieb, LS; Hegsted, DM; Iseri, OA; Vitale, JJ1
Aoyama, Y; Ashida, K; Nakanishi, M1
Hosotani, T; Yoshida, A1
Gilchrist, P; Hemsley, LA; Payne, CG; Pearson, JA1
Murphy, D; Wolford, JH1
Aoyama, Y; Ashida, K1
Dragstedt, LR; Vadhanasindhu, P2
Hayes, KC; Hegsted, DM; Said, AK1
Lieber, CS; Rubin, E1
Farber, E1
Szabb, L1
Dunn, MA; Quinn, TC; Terwedow, HA1
Gasbarrini, G; Labò, G; Miglio, F1
Noda, K1
Blum, JC; Leclercq, B; Monachon, G1
Nagasaka, Y; Osumi, Y; Shimamoto, K1
Hartroft, WS; Porta, EA; Sugioka, G1
Applegarth, DA; Cder, RJ; Cockcroft, DM; Hardwick, DF; Ross, PM1
Derevenco, V; Fekete, T; Frăţilă, I; Gligore, V; Holan, T; Scurtu, A; Tecuceanu, R1
Mahlum, DD1
Lombardi, B; Longnecker, DS; Schlunk, FF1
Barnes, RH; Krook, L; Pond, WG; Reid, IM1
Bailey, C; Newberne, PM; Rogers, AE; Young, VR1
Thomas, H1
Isozaki, M; Sano, M; Yamamoto, A1
Wheatley, DN1
Sidransky, H; Verney, E1
MacDonald, G; Mookerjea, S; Thompson, W1
Bianchi, FB; Nigro, F; Pisi, E1
Fallon, HJ; Klatskin, G; Pesch, LA1
Remy, CN; Wells, IC1
Chahl, JS; Kratzing, CC1
DeCarli, LM; Lieber, CS1

Reviews

11 review(s) available for methionine and Liver Steatosis

ArticleYear
Sulfur-Containing Amino Acids and Lipid Metabolism.
    The Journal of nutrition, 2020, 10-01, Volume: 150, Issue:Suppl 1

    Topics: Amino Acids, Sulfur; Animals; Atherosclerosis; Betaine; Cholesterol; Cysteine; Dietary Proteins; Dietary Supplements; Fatty Liver; Glutathione; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Lipid Metabolism; Methionine; Nutritional Requirements; Nutritional Status; Phosphatidylcholines; Sulfur; Sulfur Compounds; Taurine

2020
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
    Nutrients, 2013, Sep-09, Volume: 5, Issue:9

    Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Models, Animal; DNA Methylation; Fasting; Fatty Liver; Folic Acid; Homocysteine; Humans; Liver; Metabolic Networks and Pathways; Methionine; Muscular Diseases; S-Adenosylmethionine

2013
Sulfur amino acids in diet-induced fatty liver: a new perspective based on recent findings.
    Molecules (Basel, Switzerland), 2014, Jun-19, Volume: 19, Issue:6

    Topics: Amino Acids, Sulfur; Animals; Fatty Liver; Humans; Methionine; Sulfur

2014
Animal models of NASH: getting both pathology and metabolic context right.
    Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:11

    Topics: Animals; Choline Deficiency; Diet, Atherogenic; Dietary Fats; Disease Models, Animal; Disease Progression; Fatty Liver; Genetic Predisposition to Disease; Hyperphagia; Intubation, Gastrointestinal; Liver; Methionine; Overnutrition; Phenotype; Reproducibility of Results

2008
Animal models of non-alcoholic steatohepatitis: of mice and man.
    Digestive diseases (Basel, Switzerland), 2010, Volume: 28, Issue:1

    Topics: Animals; Choline Deficiency; Dietary Fats; Disease Models, Animal; Fatty Liver; Humans; Liver; Methionine; Mice

2010
The hepatocarcinogenic effect of methionine and choline deficient diets: an adaptation to the Warburg effect?
    Alcoholism, clinical and experimental research, 2011, Volume: 35, Issue:5

    Topics: Adaptation, Physiological; Animals; Carcinoma, Hepatocellular; Choline Deficiency; Fatty Liver; Humans; Liver Neoplasms; Methionine

2011
BIOCHEMICAL PATHOLOGY OF ACUTE HEPATIC ADENOSINETRIPHOSPHATE DEFICIENCY.
    Nature, 1964, Jul-04, Volume: 203

    Topics: Adenosine Triphosphate; Ethionine; Fatty Liver; Methionine; Research; Toxicology

1964
Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition.
    The Journal of nutritional biochemistry, 2007, Volume: 18, Issue:3

    Topics: Betaine; Cytokines; Dietary Supplements; Environmental Exposure; Fatty Liver; Female; Humans; Insulin Resistance; Life Style; Liver; Liver Cirrhosis; Metabolic Syndrome; Methionine; Middle Aged; Mitochondrial Diseases; Oxidative Stress; S-Adenosylmethionine; United States; Vitamin E; Xenobiotics; Zinc

2007
Nutrient and non-nutrient effects on drug metabolism.
    Drug-nutrient interactions, 1985, Volume: 4, Issue:1-2

    Topics: Acetaminophen; Aged; Antioxidants; Biological Transport; Biotransformation; Carbohydrate Metabolism; Drug Interactions; Enzyme Induction; Ethanol; Fatty Liver; Humans; Kidney; Lipid Metabolism; Methionine; Minerals; Mixed Function Oxygenases; Pharmaceutical Preparations; Proteins; Research; Starvation; Vitamins

1985
Alcoholic fatty liver.
    The New England journal of medicine, 1969, Mar-27, Volume: 280, Issue:13

    Topics: Adult; Alcoholism; Animals; Child; Choline; Diet; Dietary Fats; Dietary Proteins; Drug Synergism; Ethanol; Fatty Liver; Hepatitis; Humans; Lipid Metabolism; Lipoproteins; Liver; Liver Cirrhosis; Methionine; Microsomes; Protein Deficiency; Rats; Triglycerides

1969
Biochemical pathology.
    Annual review of pharmacology, 1971, Volume: 11

    Topics: Adenosine Triphosphate; Basidiomycota; Carbon Tetrachloride Poisoning; Cell Division; Cell Nucleus; Cycloheximide; Dactinomycin; Deficiency Diseases; Drug Antagonism; Ethionine; Fatty Liver; Fructose; Liver; Lymphoid Tissue; Methionine; Mitochondria; Mycotoxins; Nucleic Acids; Oxidative Phosphorylation; Oxygen Consumption; Peptides; Protein Biosynthesis; Ribosomes; Toxins, Biological

1971

Trials

1 trial(s) available for methionine and Liver Steatosis

ArticleYear
Four-Week Omega-3 Supplementation in Carriers of the Prosteatotic PNPLA3 p.I148M Genetic Variant: An Open-Label Study.
    Lifestyle genomics, 2019, Volume: 12, Issue:1-6

    Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Dietary Supplements; Elasticity Imaging Techniques; Fatty Acids, Omega-3; Fatty Liver; Female; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Isoleucine; Lipase; Loss of Function Mutation; Male; Membrane Proteins; Methionine; Middle Aged; Non-alcoholic Fatty Liver Disease; Polymorphism, Single Nucleotide; Proteostasis; Time Factors; Young Adult

2019

Other Studies

328 other study(ies) available for methionine and Liver Steatosis

ArticleYear
Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis.
    Journal of lipid research, 2021, Volume: 62

    Topics: Animals; Choline Deficiency; Chylomicrons; Diet; Fatty Liver; Female; Fibrosis; Inflammation; Intestines; Male; Methionine; Mice; Mice, Knockout; Mice, Transgenic; Non-alcoholic Fatty Liver Disease

2021
TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis.
    Nature communications, 2022, 09-28, Volume: 13, Issue:1

    Topics: Amino Acids, Sulfur; Animals; Antioxidants; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Coenzyme A; Cysteine; Cystine; Dietary Proteins; Fatty Liver; Glutathione; Homeostasis; Lipids; Liver; Methionine; Methionine Adenosyltransferase; Mice; Oxidation-Reduction

2022
Effect of source and amount of rumen-protected choline on hepatic metabolism during induction of fatty liver in dairy cows.
    Journal of dairy science, 2023, Volume: 106, Issue:10

    Topics: Animals; Cattle; Cattle Diseases; Cholesterol; Choline; Diet; Dietary Supplements; Fatty Acids; Fatty Liver; Female; Glucose; Glycogen; Haptoglobins; Inflammation; Lactation; Liver; Methionine; Milk; Pregnancy; RNA, Messenger; Rumen; Triglycerides

2023
Absence of Bsep/Abcb11 attenuates MCD diet-induced hepatic steatosis but aggravates inflammation in mice.
    Liver international : official journal of the International Association for the Study of the Liver, 2020, Volume: 40, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Choline; Diet; Fatty Acid-Binding Proteins; Fatty Liver; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout

2020
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
    The Journal of nutritional biochemistry, 2020, Volume: 81

    Topics: Adenosine; Animals; Carbon; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Flavins; Guanidine; Inflammation; Liver; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Nucleotides; Purinergic P1 Receptor Antagonists; Thymidine

2020
Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH.
    Cells, 2020, 05-16, Volume: 9, Issue:5

    Topics: Adenylate Kinase; Animals; Antioxidants; Apoptosis; Cell Proliferation; Ceramides; Choline; Diet; Diglycerides; Energy Metabolism; Fatty Liver; Feeding Behavior; Hematopoietic Stem Cells; Homeostasis; Humans; Lipidomics; Liposomes; Male; Methionine; Mice, Inbred BALB C; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Phosphatidylcholines; Phosphorylation; Protein Subunits; Signal Transduction

2020
Automated thermal imaging for the detection of fatty liver disease.
    Scientific reports, 2020, 09-23, Volume: 10, Issue:1

    Topics: Algorithms; Animals; Automation; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Female; Humans; Image Processing, Computer-Assisted; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Thermography; Ultrasonography

2020
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.
    Lipids in health and disease, 2020, Dec-14, Volume: 19, Issue:1

    Topics: Amino Acids; Animal Feed; Animals; Apoptosis; Body Weight; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Humans; Inflammation; Insulin-Like Growth Factor I; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Organ Size; Phosphorylation; RNA; Soybean Oil; Sulfotransferases; Trans Fatty Acids

2020
Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Animals; Biphenyl Compounds; CASP8 and FADD-Like Apoptosis Regulating Protein; Fatty Liver; Food, Formulated; Lignans; Liver; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Methionine; Mice; Oxidative Stress

2020
Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet.
    International journal of molecular sciences, 2020, Dec-23, Volume: 22, Issue:1

    Topics: Alkaline Phosphatase; Alleles; Animals; Choline; Choline Deficiency; Diet; Diet, High-Fat; Disease Models, Animal; Enzyme Activation; Fatty Liver; Methionine; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; PPAR alpha; Proto-Oncogene Proteins c-akt; Signal Transduction

2020
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
    Life sciences, 2021, Apr-01, Volume: 270

    Topics: Animals; Choline; Choline Deficiency; Cytokines; Diet; Fatty Liver; Hep G2 Cells; Humans; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Prolyl Oligopeptidases; Signal Transduction

2021
Clusters of Ultrasound Scattering Parameters for the Classification of Steatotic and Normal Livers.
    Ultrasound in medicine & biology, 2021, Volume: 47, Issue:10

    Topics: Animals; Disease Models, Animal; Fatty Liver; Liver; Methionine; Rats; Ultrasonography

2021
Long-term cold storage preservation does not affect fatty livers from rats fed with a methionine and choline deficient diet.
    Lipids in health and disease, 2021, Jul-28, Volume: 20, Issue:1

    Topics: Animals; Choline; Choline Deficiency; Diet; Fatty Liver; Liver; Male; Methionine; Rats; Rats, Wistar; Tissue Preservation

2021
Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice.
    Digestive diseases and sciences, 2017, Volume: 62, Issue:6

    Topics: Adenoviridae; Adipose Tissue; Alanine Transaminase; Animals; Choline Deficiency; Collagen Type I; Collagen Type III; Diet; Disease Models, Animal; Down-Regulation; Eye Proteins; Fatty Liver; Injections, Intramuscular; Interleukin-1beta; Interleukin-6; Kupffer Cells; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nerve Growth Factors; Oxidative Stress; PPAR gamma; Protease Inhibitors; RNA, Messenger; Serpins; Tumor Necrosis Factor-alpha; Up-Regulation

2017
Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis.
    American journal of physiology. Gastrointestinal and liver physiology, 2017, Jul-01, Volume: 313, Issue:1

    Topics: Animal Feed; Animals; Choline; Diet; Fatty Liver; Gene Expression Regulation; Lipids; Liver; Methionine; Mice; Mice, Knockout; Phospholipid Transfer Proteins; Thiolester Hydrolases

2017
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
    Free radical biology & medicine, 2017, Volume: 110

    Topics: Activating Transcription Factor 4; AMP-Activated Protein Kinases; Animals; Autophagy; Carbon Monoxide; Choline Deficiency; Disease Models, Animal; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Fatty Liver; Gene Expression Regulation; Hepatocytes; Liver; Male; Mechanistic Target of Rapamycin Complex 1; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Nuclear Proteins; Organometallic Compounds; Peroxidases; Primary Cell Culture; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction

2017
CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
    PloS one, 2017, Volume: 12, Issue:9

    Topics: Adipose Tissue; Animals; CD18 Antigens; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Hepatocytes; Immunity, Innate; Inflammation; Leukocytes; Lipase; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mutation; Oxygen; Peroxidase; Triglycerides

2017
Effects of betaine supplementation on nitric oxide metabolism, atherosclerotic parameters, and fatty liver in guinea pigs fed a high cholesterol plus methionine diet.
    Nutrition (Burbank, Los Angeles County, Calif.), 2018, Volume: 45

    Topics: Animals; Arginine; Atherosclerosis; Betaine; Cholesterol; Cholesterol, Dietary; Diet, High-Fat; Dietary Supplements; Fatty Liver; Guinea Pigs; Hyperlipidemias; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Nitric Oxide; Tyrosine

2018
Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring.
    Scientific reports, 2018, 02-14, Volume: 8, Issue:1

    Topics: Animals; Animals, Newborn; Diet; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Female; Folic Acid; Gene Expression; Lipid Metabolism; Liver; Male; Methionine; Micronutrients; Pregnancy; Prenatal Exposure Delayed Effects; Vitamin B 12; Vitamin B 6; Zebrafish; Zebrafish Proteins

2018
NNMT activation can contribute to the development of fatty liver disease by modulating the NAD
    Scientific reports, 2018, 06-05, Volume: 8, Issue:1

    Topics: Animals; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Fatty Liver; Lipoproteins, VLDL; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Transgenic; NAD; Niacinamide; Nicotinamide N-Methyltransferase

2018
Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 110

    Topics: Animals; Choline Deficiency; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fatty Liver; Inflammation; Inflammation Mediators; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Schisandra

2019
Inhibitory Effects of Sodium Alginate on Hepatic Steatosis in Mice Induced by a Methionine- and Choline-deficient Diet.
    Marine drugs, 2019, Feb-09, Volume: 17, Issue:2

    Topics: Alginates; Animals; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Fatty Liver; Intestine, Small; Male; Methionine; Mice; Mice, Inbred C57BL; RNA, Messenger; Tumor Necrosis Factor-alpha

2019
Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Amino Acids; Animals; Betaine-Homocysteine S-Methyltransferase; Carbon; Cell Line, Tumor; Cystathionine beta-Synthase; Diet, High-Fat; Fatty Liver; Gene Expression Regulation, Enzymologic; Homeostasis; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphatidylcholines; PPAR alpha; Rats; Sequence Analysis, DNA

2013
Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3.
    Molecular and cellular biology, 2013, Volume: 33, Issue:10

    Topics: Acetylation; Animals; Choline Deficiency; Fatty Liver; Food, Formulated; Gene Expression; Lipid Peroxidation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Polychlorinated Dibenzodioxins; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Sirtuin 3; Superoxide Dismutase

2013
Injury-dependent retention of intraportally administered mesenchymal stromal cells following partial hepatectomy of steatotic liver does not lead to improved liver recovery.
    PloS one, 2013, Volume: 8, Issue:7

    Topics: Analysis of Variance; Animals; Biomarkers; Body Weight; Choline Deficiency; Cholinesterases; DNA Primers; Fatty Liver; Female; Flow Cytometry; Hepatectomy; Immunophenotyping; Liver Regeneration; Luminescent Measurements; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methionine; Organ Size; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; Triglycerides

2013
Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.
    Metabolism: clinical and experimental, 2013, Volume: 62, Issue:11

    Topics: 3-Hydroxybutyric Acid; Animals; Biomarkers; Blood Glucose; Diet; Disease Progression; Fatty Acids; Fatty Liver; Gene Expression Regulation; Homeostasis; Inflammation; Insulin; Leptin; Lipid Metabolism; Lipoproteins, VLDL; Liver; Male; Methionine; Mice; Mice, Obese; Obesity; Oxidation-Reduction; Severity of Illness Index; Triglycerides

2013
Chunggan extract (CGX), methionine-and choline-deficient (MCD) diet-induced hepatosteatosis and oxidative stress in C57BL/6 mice.
    Human & experimental toxicology, 2013, Volume: 32, Issue:12

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Catalase; Cholesterol; Choline Deficiency; Diet; Drugs, Chinese Herbal; Fatty Liver; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Triglycerides

2013
Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.
    Hepatology (Baltimore, Md.), 2014, Volume: 59, Issue:3

    Topics: Animals; Choline Deficiency; Disease Models, Animal; Endotoxemia; Fatty Liver; Female; Lipase; Lipopolysaccharides; Liver; Male; Methionine; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; PPAR alpha; Signal Transduction

2014
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Aldehyde Reductase; Animals; Blotting, Western; Choline; Diet; Fatty Liver; Female; Interleukin-6; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha

2013
Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.
    American journal of physiology. Gastrointestinal and liver physiology, 2013, Volume: 305, Issue:12

    Topics: Animals; Bifidobacterium; Choline Deficiency; Disease Models, Animal; Fatty Liver; Gastrointestinal Tract; Gene Expression Profiling; Inflammation; Lacticaseibacillus casei; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Microbiota; Non-alcoholic Fatty Liver Disease

2013
Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:1

    Topics: Animals; Choline Deficiency; Cytochrome P-450 CYP2E1; Disease Models, Animal; Disease Progression; Fatty Liver; Heme Oxygenase-1; Hydrogen Sulfide; Inflammation; Interleukin-6; Liver; Male; Methionine; Mitochondria, Liver; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2014
IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet.
    American journal of physiology. Gastrointestinal and liver physiology, 2013, Volume: 305, Issue:12

    Topics: Animals; Cell Line; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Hepatic Stellate Cells; Inflammation; Interferon-gamma; Kupffer Cells; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2013
Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver.
    Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:11

    Topics: Animals; Choline Deficiency; Diabetes Mellitus; Diet; Diet, High-Fat; Fatty Liver; Female; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Obesity; PPAR gamma; Proteins; RNA, Messenger

2013
Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Amides; Angiotensin II; Animals; Blotting, Western; Choline; Diet; Fatty Liver; Fumarates; Immunoenzyme Techniques; Inflammation; Insulin; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Oxidative Stress; Real-Time Polymerase Chain Reaction; Renin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Triglycerides

2013
Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice.
    International journal of clinical and experimental pathology, 2013, Volume: 6, Issue:12

    Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aspartate Aminotransferases; Biomarkers; Cell Proliferation; Chemokine CCL2; Choline Deficiency; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Kupffer Cells; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proliferating Cell Nuclear Antigen; RNA, Messenger; Time Factors

2013
The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD.
    Journal of medicinal food, 2014, Volume: 17, Issue:2

    Topics: Animals; Choline; Diet; Fatty Acids, Nonesterified; Fatty Liver; Humans; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Thioctic Acid

2014
Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:5

    Topics: Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Choline Deficiency; Fatty Liver; Female; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Methionine; Mice, Inbred C57BL; Middle Aged; Molecular Targeted Therapy

2014
Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes.
    Iranian biomedical journal, 2014, Volume: 18, Issue:1

    Topics: Animals; Antioxidants; Ascorbic Acid; Chelating Agents; Choline; Diet; Ethylenediamines; Fatty Liver; Inflammation; Liver; Male; Manganese Compounds; Methionine; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats

2014
Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:4

    Topics: Animals; Choline Deficiency; Diabetes Mellitus, Experimental; Diet, Atherogenic; Disease Models, Animal; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Obesity; Organic Anion Transporters; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Tissue Distribution

2014
Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Animals; Apoptosis; Biomarkers; Cells, Cultured; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Enzyme Activation; Fatty Liver; Female; Gene Expression; Hepatocytes; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Primary Cell Culture; Protein Kinase C-delta

2014
Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease.
    Archives of medical research, 2014, Volume: 45, Issue:2

    Topics: Animals; Choline; Diet; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes; Lipids; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Risk Factors; Time Factors

2014
Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).
    Biochimica et biophysica acta, 2014, Volume: 1842, Issue:7

    Topics: Adipogenesis; Adipose Tissue; Animals; Choline; Disease Models, Animal; Fatty Acids; Fatty Acids, Nonesterified; Fatty Liver; Fibroblast Growth Factors; Inflammation; Lipase; Lipid Metabolism; Lipolysis; Liver; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Oxidation-Reduction

2014
Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:2

    Topics: Animals; Annexin A1; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Hepatitis; Humans; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Obesity

2014
GH administration rescues fatty liver regeneration impairment by restoring GH/EGFR pathway deficiency.
    Endocrinology, 2014, Volume: 155, Issue:7

    Topics: Animals; Blotting, Western; Cell Proliferation; Choline; Diet; Down-Regulation; ErbB Receptors; Fatty Liver; Hepatectomy; Hepatocytes; Human Growth Hormone; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Obese; Non-alcoholic Fatty Liver Disease; Obesity; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Triglycerides

2014
Bile acids override steatosis in farnesoid X receptor deficient mice in a model of non-alcoholic steatohepatitis.
    Biochemical and biophysical research communications, 2014, May-23, Volume: 448, Issue:1

    Topics: Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear

2014
Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model.
    Digestive diseases and sciences, 2014, Volume: 59, Issue:6

    Topics: Animals; Antigens, Ly; Apoptosis; Caspase 3; Choline; Collagen; Dose-Response Relationship, Drug; Fatty Liver; Gene Expression Regulation; Hepatic Stellate Cells; Hepatocytes; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Receptors, CCR2

2014
Sitagliptin attenuates methionine/choline-deficient diet-induced steatohepatitis.
    Diabetes research and clinical practice, 2014, Volume: 105, Issue:1

    Topics: Animals; Biomarkers; Blotting, Western; Choline Deficiency; Diet; Dipeptidyl-Peptidase IV Inhibitors; Endoplasmic Reticulum Stress; Fatty Liver; Immunoenzyme Techniques; Inflammation; Lipid Peroxidation; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Pyrazines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sitagliptin Phosphate; Triazoles; Triglycerides

2014
Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis.
    Archives of biochemistry and biophysics, 2014, Volume: 555-556

    Topics: Animals; Choline; Diet; Fatty Liver; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Oxidative Stress; Taurine

2014
Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet.
    Digestive diseases and sciences, 2014, Volume: 59, Issue:7

    Topics: Animal Feed; Animals; Apoptosis; Biomarkers; Choline Deficiency; Disease Progression; Drug Administration Schedule; Endoplasmic Reticulum Stress; Fatty Liver; Gastrointestinal Agents; Immunoblotting; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Taurochenodeoxycholic Acid

2014
Standardized Salvia miltiorrhiza extract suppresses hepatic stellate cell activation and attenuates steatohepatitis induced by a methionine-choline deficient diet in mice.
    Molecules (Basel, Switzerland), 2014, Jun-17, Volume: 19, Issue:6

    Topics: Animals; Choline; Diet; Fatty Liver; Hepatic Stellate Cells; Humans; Hydrogen Peroxide; Male; Methionine; Mice; Mice, Inbred C57BL; Plant Extracts; Salvia miltiorrhiza

2014
Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency.
    Journal of agricultural and food chemistry, 2015, Jan-21, Volume: 63, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Anthocyanins; Choline Deficiency; Fatty Liver; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Plant Extracts; Ribes; Transcription Factors; Vaccinium myrtillus

2015
6-gingerol protects against nutritional steatohepatitis by regulating key genes related to inflammation and lipid metabolism.
    Nutrients, 2015, Feb-04, Volume: 7, Issue:2

    Topics: Animals; Catechols; Chemokine CCL2; Choline Deficiency; Disease Models, Animal; Fatty Alcohols; Fatty Liver; Inflammation; Interleukin-6; Lipid Metabolism; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Plant Extracts; Tumor Necrosis Factor-alpha

2015
The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways.
    Journal of applied toxicology : JAT, 2015, Volume: 35, Issue:12

    Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Cytosine; Deoxyguanosine; DNA Methylation; Fatty Liver; Gene Expression Regulation, Enzymologic; Liver; Male; Methionine; Mice, Inbred C57BL; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine

2015
Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.
    Genes to cells : devoted to molecular & cellular mechanisms, 2015, Volume: 20, Issue:6

    Topics: Alcohol Dehydrogenase; Animals; Choline Deficiency; Diet; Disease Progression; Fatty Liver; Glutathione; Lipid Metabolism; Liver; Methionine; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease

2015
MRI versus histological methods for time course monitoring of steatosis amount in a murine model of NAFLD.
    Diagnostic and interventional imaging, 2015, Volume: 96, Issue:9

    Topics: Adipose Tissue; Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Humans; Image Interpretation, Computer-Assisted; Liver; Magnetic Resonance Imaging; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; Statistics as Topic; Triglycerides

2015
MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Nucleus; Choline; Diet; Disease Models, Animal; Fatty Liver; Female; Gene Expression Regulation; Inflammation; Lipid Metabolism; Lipopolysaccharides; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; MicroRNAs; Protein Binding; Smad3 Protein; Tumor Necrosis Factor-alpha; Vimentin

2015
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
    Journal of hepatology, 2016, Volume: 64, Issue:2

    Topics: Animals; Autophagy; Cell Culture Techniques; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Methionine; Methylation; Mice; Protein Phosphatase 2; S-Adenosylmethionine

2016
In Situ Evaluation of Oxidative Stress in Rat Fatty Liver Induced by a Methionine- and Choline-Deficient Diet.
    Oxidative medicine and cellular longevity, 2016, Volume: 2016

    Topics: Adenosine Triphosphate; Animals; Blotting, Western; Choline; Diet; Fatty Liver; Glutathione; Glycogen; Hydrazines; Immunohistochemistry; Liver; Male; Methionine; Oxidative Stress; Protein Carbonylation; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2016
Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice.
    Metabolic syndrome and related disorders, 2016, Volume: 14, Issue:4

    Topics: Animals; Choline; Diet; Dietary Fats; Dietary Sucrose; Dietary Supplements; Fatty Liver; Feeding Behavior; Female; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C3H; S-Adenosylhomocysteine; S-Adenosylmethionine

2016
Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice.
    Hepatology (Baltimore, Md.), 2016, Volume: 64, Issue:1

    Topics: Animals; CD36 Antigens; Fatty Liver; Hepatocytes; Hyperhomocysteinemia; Lipid Metabolism; Lipoxins; Liver; Male; Methionine; Mice, Inbred C57BL; Receptors, Aryl Hydrocarbon

2016
Ischemia-Reperfusion Injury in Fatty Liver Is Mediated by Activated NADPH Oxidase 2 in Rats.
    Transplantation, 2016, Volume: 100, Issue:4

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cells, Cultured; Choline Deficiency; Deoxyguanosine; Disease Models, Animal; Enzyme Inhibitors; Fatty Liver; HMGB1 Protein; Inflammation Mediators; Interleukin-6; Liver; Macrophages; Male; Membrane Glycoproteins; Methionine; NADPH Oxidase 2; NADPH Oxidases; Necrosis; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Time Factors; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2016
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
    Molecular and cellular biochemistry, 2016, Volume: 419, Issue:1-2

    Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Choline; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Male; Methionine; Rats; Rats, Wistar

2016
In ovo injection of betaine alleviates corticosterone-induced fatty liver in chickens through epigenetic modifications.
    Scientific reports, 2017, 01-06, Volume: 7

    Topics: Animals; Betaine; Body Weight; Chickens; Corticosterone; DNA Methylation; DNA, Mitochondrial; Eating; Epigenesis, Genetic; Fatty Liver; Liver; Male; Methionine; Zygote

2017
A compromised liver alters polychlorinated biphenyl-mediated toxicity.
    Toxicology, 2017, 04-01, Volume: 380

    Topics: Adipokines; Animals; Aroclors; Biomarkers; Blood Glucose; Cardiovascular Diseases; Choline; Diet; Disease Models, Animal; Energy Metabolism; Fatty Liver; Gene Expression; Homeostasis; Inflammation; Liver; Liver Cirrhosis; Male; Methionine; Mice, Inbred C57BL; Polychlorinated Biphenyls

2017
Influence of hyperglycemia on liver inflammatory conditions in the early phase of non-alcoholic fatty liver disease in mice.
    The Journal of pharmacy and pharmacology, 2017, Volume: 69, Issue:6

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Hyperglycemia; Inflammation; Liver; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha

2017
Suv39h2 deficiency ameliorates diet-induced steatosis in mice.
    Biochemical and biophysical research communications, 2017, Apr-08, Volume: 485, Issue:3

    Topics: Animals; Blotting, Western; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Gene Expression; Histone-Lysine N-Methyltransferase; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Sirtuin 1; Up-Regulation

2017
MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes.
    Journal of hepatology, 2008, Volume: 49, Issue:3

    Topics: Adipocytes; Adipogenesis; Adiponectin; Alanine Transaminase; AMP-Activated Protein Kinase Kinases; Animals; Choline Deficiency; Dietary Fats; Disease Models, Animal; Fatty Acid-Binding Proteins; Fatty Liver; Female; Hepatitis; Hepatocytes; Lipid Peroxides; Methionine; Mice; Mice, Inbred C57BL; PPAR gamma; Protein Kinases; Triglycerides

2008
Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2008, Volume: 48, Issue:1

    Topics: Animals; Carnitine O-Palmitoyltransferase; Cell Line; Choline Deficiency; Diet; Fatty Acids; Fatty Liver; Interleukin-6; Kupffer Cells; Lipopolysaccharides; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; ortho-Aminobenzoates; Oxidation-Reduction; Oxidative Stress; PPAR alpha; Rats; Rats, Inbred OLETF; RNA, Messenger; Transforming Growth Factor beta; Up-Regulation

2008
Hepatic metabolism of glucose and linoleic acid varies in relation to susceptibility to fatty liver in ad libitum-fed Muscovy and Pekin ducks.
    The British journal of nutrition, 2009, Volume: 101, Issue:4

    Topics: Animal Feed; Animals; Disease Susceptibility; Ducks; Fatty Liver; Genotype; Glucose; Linoleic Acid; Lipoproteins, VLDL; Liver; Methionine; Models, Animal; Poultry Diseases; Species Specificity; Tissue Culture Techniques

2009
Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice.
    Hepatology (Baltimore, Md.), 2008, Volume: 48, Issue:2

    Topics: Animals; Catalase; Cells, Cultured; Choline Deficiency; Diet; Disease Progression; Enzyme Activation; Fatty Liver; Gene Transfer Techniques; Hepatocytes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha; Reactive Oxygen Species; Receptors, Adiponectin; Signal Transduction; Transforming Growth Factor beta1

2008
Is the hepatic metabolism of glucose and linoleic acid influenced by species in overfed ducks?
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2008, Volume: 151, Issue:4

    Topics: Animals; Ducks; Eating; Fatty Liver; Glucose; In Vitro Techniques; Linoleic Acid; Lipoproteins, VLDL; Liver; Male; Methionine; Species Specificity

2008
VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice.
    Hepatology (Baltimore, Md.), 2009, Volume: 49, Issue:3

    Topics: Actins; Animals; Choline Deficiency; Collagen Type I; Diet; Disease Models, Animal; Fatty Liver; Female; Liver Cirrhosis; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Peroxisome Proliferator-Activated Receptors; Probiotics; Signal Transduction; Transforming Growth Factor beta

2009
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase.
    The Journal of biological chemistry, 2009, Feb-27, Volume: 284, Issue:9

    Topics: Animals; Apoptosis; Cell Survival; Choline Deficiency; Disease Models, Animal; Fatty Acids; Fatty Liver; Fluorescent Antibody Technique; Hepatocytes; Immunoblotting; Lipids; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Small Interfering; Stearoyl-CoA Desaturase

2009
Utility of a 13C-methacetin breath test in evaluating hepatic injury in rats.
    Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:11

    Topics: Acetamides; Administration, Oral; Animals; Breath Tests; Carbon Isotopes; Choline Deficiency; Disease Models, Animal; Fatty Liver; Hepatectomy; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Liver Failure, Acute; Liver Function Tests; Male; Methionine; Organ Size; Predictive Value of Tests; Rats; Rats, Wistar; Severity of Illness Index; Thioacetamide; Time Factors

2008
Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation.
    Journal of hepatology, 2009, Volume: 50, Issue:3

    Topics: Adiponectin; AMP-Activated Protein Kinase Kinases; Animals; Choline Deficiency; DNA Primers; Fatty Liver; Female; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pioglitazone; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sterol Regulatory Element Binding Protein 1; Thiazolidinediones

2009
TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.
    Development (Cambridge, England), 2009, Volume: 136, Issue:5

    Topics: Adenosylhomocysteinase; Animals; Base Sequence; Disease Models, Animal; DNA Primers; Fatty Liver; Humans; Larva; Lipogenesis; Liver Diseases; Male; Methionine; Mitochondria, Liver; Models, Biological; Mutation; Oxidative Stress; Phenotype; Species Specificity; Tubercidin; Tumor Necrosis Factor-alpha; Zebrafish; Zebrafish Proteins

2009
Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression.
    Journal of gastroenterology and hepatology, 2009, Volume: 24, Issue:3

    Topics: Alanine Transaminase; Animals; Apoptosis; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; fas Receptor; Fatty Liver; Gene Expression Regulation; Insulin-Like Growth Factor I; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nutritional Status; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Messenger; Time Factors; Tumor Suppressor Protein p53

2009
Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis.
    Journal of lipid research, 2009, Volume: 50, Issue:10

    Topics: Animals; Blood Glucose; Body Weight; Choline Deficiency; Fatty Acids; Fatty Liver; In Situ Nick-End Labeling; Lipid Peroxidation; Lipids; Liver; Male; Methionine; Mice; Polymerase Chain Reaction; Sucrose

2009
Metabolism of methionine in vivo: impact of pregnancy, protein restriction, and fatty liver disease.
    Nestle Nutrition workshop series. Paediatric programme, 2009, Volume: 63

    Topics: Animals; Diet, Protein-Restricted; Disease Models, Animal; Fatty Liver; Female; Fetal Growth Retardation; Folic Acid; Humans; Insulin Resistance; Methionine; Models, Animal; Pregnancy

2009
Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue.
    Liver international : official journal of the International Association for the Study of the Liver, 2009, Volume: 29, Issue:7

    Topics: Adipocytes; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blood Pressure; Cell Line; Cell Size; Chemokine CCL2; Choline Deficiency; Collagen Type I; Disease Models, Animal; Disease Progression; Drinking; Eating; Fatty Liver; Intra-Abdominal Fat; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Organ Size; Oxidative Stress; Receptors, CCR2; RNA, Messenger; Telmisartan; Transforming Growth Factor beta1; Triglycerides

2009
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.
    Journal of hepatology, 2009, Volume: 51, Issue:1

    Topics: Animals; Choline Deficiency; Disease Susceptibility; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Folic Acid Deficiency; Histones; Liver; Male; Methionine; Mice; Mice, Inbred Strains; Phenotype; Species Specificity

2009
Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis.
    Journal of hepatology, 2009, Volume: 51, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azepines; Chemokine CCL2; Chemokines; Choline Deficiency; Fatty Liver; Hepatitis; Indoles; Lipids; Liver Cirrhosis, Experimental; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Triglycerides

2009
Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats.
    Journal of pineal research, 2009, Volume: 46, Issue:4

    Topics: Animals; Apoptosis; Biomarkers; Choline; Choline Deficiency; Cytokines; Diet; Fatty Liver; Glutathione; Histocytochemistry; Liver; Male; Malondialdehyde; Melatonin; Methionine; Oxidative Stress; Rats; Rats, Wistar; Statistics, Nonparametric; Superoxide Dismutase

2009
Children's toxicology from bench to bed--Liver Injury (2): Mechanism of antioxidant therapy for nonalcoholic fatty liver disease.
    The Journal of toxicological sciences, 2009, Volume: 34 Suppl 2

    Topics: alpha-Tocopherol; Animals; Antioxidants; Carrier Proteins; Choline Deficiency; Disease Models, Animal; Fatty Liver; Liver; Male; Methionine; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Vitamin E

2009
MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice.
    Alcoholism, clinical and experimental research, 2009, Volume: 33, Issue:10

    Topics: Animals; Central Nervous System Depressants; Choline Deficiency; Cytokines; Diet; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; Female; Inflammation; Lipid Metabolism; Liver; Liver Function Tests; Methionine; Mice; Mice, Inbred C57BL; MicroRNAs

2009
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.
    Gastroenterology, 2009, Volume: 137, Issue:4

    Topics: Animals; Case-Control Studies; Cell Line; Cell Transdifferentiation; Choline Deficiency; Disease Progression; Epithelial Cells; Fatty Liver; Fibroblasts; Hedgehog Proteins; Humans; Liver Cirrhosis, Experimental; Methionine; Mice; Mice, Inbred C57BL; Patched Receptors; Patched-1 Receptor; Rats; Receptors, Cell Surface; Recombinant Proteins; RNA, Messenger; Signal Transduction; Veratrum Alkaloids

2009
Teucrium polium in prevention of steatohepatitis in rats.
    Liver international : official journal of the International Association for the Study of the Liver, 2009, Volume: 29, Issue:8

    Topics: Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Choline Deficiency; Disease Models, Animal; Fatty Liver; Hepatitis; Lipoproteins; Liver; Male; Methionine; Oxidoreductases; Plant Extracts; Rats; Teucrium

2009
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:5

    Topics: Actins; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Choline Deficiency; Diabetes Complications; Disease Models, Animal; Enzyme Inhibitors; Fatty Liver; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Obese; Obesity

2009
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis.
    The Journal of biological chemistry, 2009, Nov-13, Volume: 284, Issue:46

    Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Liver; Female; Homocysteine; Liver; Liver Neoplasms; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Unfolded Protein Response

2009
Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice.
    Antioxidants & redox signaling, 2009, Volume: 11, Issue:10

    Topics: Animals; Carrier Proteins; Choline Deficiency; Diet; Fatty Liver; Female; Fibrosis; Hepatitis; Interferon-gamma; Interleukin-1beta; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; NF-kappa B; Oxidative Stress; Thioredoxins; Triglycerides; Tumor Necrosis Factor-alpha

2009
Heme oxygenase-1 protects against steatohepatitis in both cultured hepatocytes and mice.
    Gastroenterology, 2010, Volume: 138, Issue:2

    Topics: Animals; Cell Line; Cells, Cultured; Disease Models, Animal; Fatty Liver; Heme Oxygenase-1; Hemin; Hepatocytes; Liver; Male; Mesoporphyrins; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha; Sterol Regulatory Element Binding Protein 1

2010
Curcumin limits the fibrogenic evolution of experimental steatohepatitis.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:1

    Topics: Actins; Alanine Transaminase; Animals; CD11b Antigen; Cells, Cultured; Chemokine CCL2; Choline; Choline Deficiency; Collagen Type I; Curcumin; Diet; Enzyme Inhibitors; Fatty Liver; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Muscle, Smooth; Oxidative Stress; Reactive Oxygen Species; Tissue Inhibitor of Metalloproteinase-1

2010
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.
    Free radical biology & medicine, 2010, Jan-15, Volume: 48, Issue:2

    Topics: Animals; Choline; Cyclooxygenase 2; Disease Progression; Fatty Liver; Food, Formulated; Interleukin-1beta; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Tumor Necrosis Factor-alpha

2010
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice.
    American journal of physiology. Gastrointestinal and liver physiology, 2010, Volume: 298, Issue:2

    Topics: Animal Feed; Animals; Choline; Choline Deficiency; Disease Progression; Fatty Liver; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; RNA, Messenger

2010
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis.
    PloS one, 2009, Nov-20, Volume: 4, Issue:11

    Topics: Animal Feed; Animals; Apoptosis; Choline; Disease Models, Animal; Fatty Liver; Inflammation; Interleukin-6; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; PPAR gamma

2009
Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:2

    Topics: Animals; Choline; Disease Models, Animal; Endoplasmic Reticulum; Fatty Liver; Inflammation; Liver Cirrhosis; Male; Methionine; Oxidative Stress; Rats; Rats, Wistar

2010
Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice.
    The American journal of pathology, 2010, Volume: 176, Issue:1

    Topics: Alanine Transaminase; Animals; Blood Coagulation; Blood Coagulation Factors; Chemokine CCL2; Choline; Diet; Fatty Liver; Gene Expression Regulation; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Models, Biological; Receptor, PAR-1; Thrombin; Thromboplastin; Triglycerides

2010
Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis.
    The American journal of pathology, 2010, Volume: 176, Issue:2

    Topics: Animals; beta Catenin; Bile Acids and Salts; Cholesterol; Choline Deficiency; Diet; Fatty Liver; Genetic Predisposition to Disease; Homeostasis; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Knockout; Organ Specificity; Stress, Physiological

2010
Methionine limitation results in increased hepatic FAS activity, higher liver 18:1 to 18:0 fatty acid ratio and hepatic TAG accumulation in Atlantic salmon, Salmo salar.
    Amino acids, 2010, Volume: 39, Issue:2

    Topics: Amino Acids; Animals; Fatty Acid Synthases; Fatty Acids; Fatty Liver; Liver; Methionine; Salmo salar; Triglycerides

2010
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death.
    American journal of physiology. Endocrinology and metabolism, 2010, Volume: 298, Issue:5

    Topics: Animals; Blood Glucose; Cell Death; Cells, Cultured; Choline Deficiency; Diet; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Fatty Liver; Hepatocytes; Insulin; Methionine; Mice; Mice, Knockout; Molecular Chaperones; Palmitic Acid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factor CHOP; Unfolded Protein Response

2010
[Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2010, Volume: 18, Issue:2

    Topics: Animals; Apoptosis; Caspases; Cell Proliferation; Choline; Choline Deficiency; Diet; Disease Models, Animal; Endoplasmic Reticulum; Fatty Liver; Liver; Liver Cirrhosis; Male; Methionine; Random Allocation; Rats; Rats, Wistar; RNA, Messenger

2010
Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling.
    Journal of hepatology, 2010, Volume: 52, Issue:4

    Topics: Adiponectin; Animals; Apoptosis; Choline Deficiency; Cytokines; Disease Models, Animal; Fatty Liver; Hepatectomy; Hepatocytes; Kupffer Cells; Ligation; Liver Regeneration; Male; Methionine; Portal Vein; PPAR alpha; Preoperative Care; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Adiponectin; RNA, Messenger; Signal Transduction; Technetium Tc 99m Disofenin

2010
[Mechanism of hepatocyte regeneration inhibition in rats with liver fibrosis induced by lipogenic methionine-choline- deficient diet].
    Zhonghua yi xue za zhi, 2009, Dec-29, Volume: 89, Issue:48

    Topics: Animals; Apoptosis; Cell Proliferation; Choline Deficiency; Diet; Fatty Liver; Hepatocytes; Liver Cirrhosis; Methionine; Rats

2009
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet.
    Toxicology and applied pharmacology, 2010, Jun-15, Volume: 245, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Animals; Body Weight; Choline Deficiency; Cytoskeletal Proteins; Disease Models, Animal; Fatty Acids; Fatty Liver; Genotype; Glutathione; Glutathione Transferase; Isoenzymes; Kelch-Like ECH-Associated Protein 1; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Organ Size; Phenotype; RNA, Messenger; Severity of Illness Index; Signal Transduction

2010
Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:8

    Topics: Alanine Transaminase; Animals; Choline; Choline Deficiency; Diet; Fatty Liver; Genes; Interleukin-6; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha; Receptors, Interleukin-6; Signal Transduction; Sterol Regulatory Element Binding Protein 1

2010
PPARgamma is essential for protection against nonalcoholic steatohepatitis.
    Gene therapy, 2010, Volume: 17, Issue:6

    Topics: Adenoviridae; Animals; Choline Deficiency; Fatty Liver; Gene Transfer Techniques; Genetic Therapy; Methionine; Mice; PPAR gamma; Rosiglitazone; Thiazolidinediones

2010
Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione.
    The Journal of biological chemistry, 2010, Jun-11, Volume: 285, Issue:24

    Topics: Animal Feed; Animals; Ceramides; Choline; Fatty Liver; Glutathione; Inflammation; Lipids; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Prodrugs; S-Adenosylmethionine; Sphingomyelin Phosphodiesterase

2010
Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis.
    BMC gastroenterology, 2010, May-28, Volume: 10

    Topics: Animals; Choline Deficiency; Collagen Type I; Dietary Fats; Dietary Fats, Unsaturated; Disease Models, Animal; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR gamma; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2010
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.
    Hepatology (Baltimore, Md.), 2010, Volume: 51, Issue:6

    Topics: Animals; Choline Deficiency; Fatty Liver; Fibrosis; Hedgehog Proteins; Hepatic Stellate Cells; Humans; Liver; Methionine; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Signal Transduction

2010
Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet.
    Liver international : official journal of the International Association for the Study of the Liver, 2010, Volume: 30, Issue:8

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Blood Glucose; Cholesterol; Choline Deficiency; Diet; Dietary Sucrose; Fatty Liver; Fructose; Gene Expression Profiling; Gene Expression Regulation; Lipid Peroxidation; Lipogenesis; Liver; Male; Methionine; Mice; Mice, Mutant Strains; Reverse Transcriptase Polymerase Chain Reaction; Triglycerides

2010
Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:12

    Topics: Acyl Coenzyme A; Acyl-CoA Oxidase; Animals; Antioxidants; Carnitine O-Palmitoyltransferase; Choline; Diet; Disease Progression; Fatty Liver; Glutathione; Hepatocytes; Inflammation; Ion Channels; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Oxidative Stress; Uncoupling Protein 2

2010
Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis.
    Journal of hepatology, 2010, Volume: 53, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspase Inhibitors; Choline Deficiency; Cysteine Proteinase Inhibitors; Dietary Fats; Disease Models, Animal; Fatty Liver; Humans; Male; Methionine; Mice; Mice, Inbred C3H; Mice, Obese; Oxidative Stress

2010
Stress signaling in the methionine-choline-deficient model of murine fatty liver disease.
    Gastroenterology, 2010, Volume: 139, Issue:5

    Topics: Animals; Apoptosis; Blotting, Western; Caspase 12; Choline Deficiency; Disease Models, Animal; DNA-Binding Proteins; Fatty Liver; Genes, MHC Class II; JNK Mitogen-Activated Protein Kinases; Liver; Male; Methionine; Mice; Mice, Inbred C3H; Oxidative Stress; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors; Triglycerides

2010
Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet.
    Laboratory investigation; a journal of technical methods and pathology, 2010, Volume: 90, Issue:12

    Topics: Animals; Chemokine CCL2; Choline Deficiency; Diet; Fatty Liver; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Transforming Growth Factor beta

2010
Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:4

    Topics: Actins; Animals; Choline Deficiency; Connective Tissue Growth Factor; Disease Progression; Eicosapentaenoic Acid; Fatty Liver; Liver; Liver Cirrhosis; Male; Methionine; Non-alcoholic Fatty Liver Disease; Procollagen; Rats; Rats, Wistar; Reactive Oxygen Species; Transforming Growth Factor beta1; Treatment Outcome; Triglycerides

2011
Increased susceptibility to experimental steatohepatitis induced by methionine-choline deficiency in HBs-Tg mice.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2010, Volume: 9, Issue:5

    Topics: Alanine Transaminase; Animal Feed; Animals; Choline Deficiency; Disease Models, Animal; Disease Susceptibility; Fatty Liver; Hepatitis B Surface Antigens; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proliferating Cell Nuclear Antigen; Statistics, Nonparametric

2010
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:1

    Topics: Animals; Cell Line; Choline Deficiency; Diet; Fatty Liver; Hedgehog Proteins; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Osteopontin; Up-Regulation; Veratrum Alkaloids

2011
Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice.
    Scandinavian journal of gastroenterology, 2011, Volume: 46, Issue:3

    Topics: Adenoviridae; Anilides; Animals; beta-Galactosidase; Choline; Diet; Fatty Liver; Genetic Vectors; Inflammation; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Methionine; Mice; Mice, Inbred C57BL; PPAR gamma; Random Allocation; Rosiglitazone; Thiazolidinediones; Transfection

2011
Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice.
    Lipids in health and disease, 2010, Oct-28, Volume: 9

    Topics: Animals; Apoptosis; Fatty Liver; Heme Oxygenase-1; Hemin; Hepatocytes; In Situ Nick-End Labeling; Male; Methionine; Mice; Mice, Inbred C57BL; Protoporphyrins

2010
The mechanism of action of the antifatty liver factor of the pancreas; free methionine prevents fatty livers in completely depancreatized dogs maintained with insulin and fed a lean meat diet.
    The Journal of biological chemistry, 1945, Volume: 160

    Topics: Animals; Diet; Dogs; Fatty Liver; Insulin; Liver; Meat; Methionine; Pancreas

1945
Teucrium polium reversed the MCD diet-induced liver injury in rats.
    Human & experimental toxicology, 2011, Volume: 30, Issue:9

    Topics: Animals; Antioxidants; Caspase 3; Choline Deficiency; Fatty Liver; Gene Expression; Glutathione Peroxidase; Liver; Male; Malondialdehyde; MAP Kinase Kinase 4; Methionine; Plant Extracts; Rats; Rats, Inbred Strains; Superoxide Dismutase; Teucrium; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2011
Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis.
    American journal of physiology. Endocrinology and metabolism, 2011, Volume: 300, Issue:2

    Topics: Adipose Tissue; Animals; Choline Deficiency; Diet; Eating; Fatty Acids; Fatty Liver; Gas Chromatography-Mass Spectrometry; Hepatitis; Hepatocytes; Immunohistochemistry; Kinetics; Lipogenesis; Liver; Male; Metabolic Networks and Pathways; Methionine; Mice; Mice, Inbred C57BL; Organ Size; Palmitic Acids; Triglycerides

2011
Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis.
    Carcinogenesis, 2011, Volume: 32, Issue:4

    Topics: Animals; Cell Proliferation; Choline Deficiency; Constitutive Androstane Receptor; Disease Models, Animal; Fatty Liver; Genes, myc; Hep G2 Cells; Humans; Ki-67 Antigen; Liver Neoplasms, Experimental; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Pyridines; Receptors, Cytoplasmic and Nuclear

2011
Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice.
    American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 300, Issue:3

    Topics: Actins; Alanine Transaminase; Animals; Choline Deficiency; Collagen; Fatty Liver; Female; Genotype; Lipid Peroxidation; Liver; Liver Cirrhosis, Experimental; Lymphocyte Antigen 96; Matrix Metalloproteinase 2; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phenotype; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Tissue Inhibitor of Metalloproteinase-1; Toll-Like Receptor 4; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha

2011
Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by (1) H-magnetic resonance spectroscopy in a rat model.
    Journal of gastroenterology and hepatology, 2011, Volume: 26, Issue:2

    Topics: Animals; Antioxidants; Choline Deficiency; Chromatography, Gas; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-3; Fatty Liver; Inflammation Mediators; Interleukin-6; Lipid Metabolism; Liver; Magnetic Resonance Spectroscopy; Male; Methionine; Rats; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha

2011
Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention.
    Physiological genomics, 2011, Apr-27, Volume: 43, Issue:8

    Topics: Animals; Blood Glucose; Carbon; Cholesterol; Choline; Dietary Fats; Fatty Liver; Hyperglycemia; Insulin; Insulin Resistance; Liver; Methionine; Mice; Mice, Inbred C57BL; Obesity; Triglycerides

2011
Induction of heme oxygenase-1 protects against nutritional fibrosing steatohepatitis in mice.
    Lipids in health and disease, 2011, Feb-12, Volume: 10

    Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Enzyme Induction; Fatty Liver; Heme Oxygenase-1; Hemin; Lipid Peroxides; Liver; Liver Cirrhosis; Male; Malondialdehyde; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Proteins; Methionine; Mice; Mice, Inbred C57BL; Protoporphyrins; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Up-Regulation

2011
Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice.
    Laboratory investigation; a journal of technical methods and pathology, 2011, Volume: 91, Issue:4

    Topics: Animals; Antibodies, Neutralizing; Apoptosis; Choline Deficiency; Diet; DNA-(Apurinic or Apyrimidinic Site) Lyase; Fatty Liver; Fibrosis; Gene Expression; Hepatocytes; Injections, Intraperitoneal; Interleukin-6; Leptin; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, Interleukin-6; Signal Transduction; STAT3 Transcription Factor

2011
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
    Hepatology (Baltimore, Md.), 2011, Volume: 53, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Biopsy; Choline Deficiency; Cytokines; Disease Models, Animal; Fatty Liver; Female; Humans; Interferon Type I; Liver; Methionine; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Poly I-C; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Double-Stranded

2011
Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine.
    Clinical science (London, England : 1979), 2011, Volume: 121, Issue:4

    Topics: Adipokines; Adult; Aged; Calorimetry, Indirect; Case-Control Studies; Cysteine; Fatty Liver; Female; Glutathione; Homocysteine; Humans; Inflammation Mediators; Insulin Resistance; Liver; Male; Methionine; Methylation; Middle Aged; Non-alcoholic Fatty Liver Disease; Phenylalanine; Proteins; Urea; Young Adult

2011
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.
    Hepatology (Baltimore, Md.), 2011, Volume: 54, Issue:1

    Topics: Animals; Apoptosis; Caspase 1; Choline Deficiency; Dietary Fats; Disease Models, Animal; Endotoxins; Fatty Acids; Fatty Liver; Female; Hepatocytes; Immune System; Inflammasomes; Interleukin-1beta; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha

2011
The effect of hepatic ischemia reperfusion injury in a murine model of nonalcoholic steatohepatitis.
    The Journal of surgical research, 2011, Volume: 169, Issue:1

    Topics: Alanine Transaminase; Animals; Diet; Disease Models, Animal; Disease Progression; Fatty Liver; Ischemia; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Peroxidase; Reperfusion Injury

2011
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis.
    Hepatology (Baltimore, Md.), 2011, Volume: 54, Issue:5

    Topics: Activating Transcription Factor 6; Animal Feed; Animals; Choline; Choline Deficiency; Cytokines; Diabetes Mellitus, Experimental; Eukaryotic Initiation Factor-2; Fatty Liver; Female; JNK Mitogen-Activated Protein Kinases; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Non-alcoholic Fatty Liver Disease; Obesity; Protein Phosphatase 1; Signal Transduction; Transcription Factor CHOP; Unfolded Protein Response

2011
The non-invasive (13)C-methionine breath test detects hepatic mitochondrial dysfunction as a marker of disease activity in non-alcoholic steatohepatitis.
    European journal of medical research, 2011, Jun-21, Volume: 16, Issue:6

    Topics: Adult; Aged; Biomarkers; Breath Tests; Carbon Isotopes; Case-Control Studies; Cross-Sectional Studies; Fatty Liver; Female; Humans; Male; Methionine; Middle Aged; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; ROC Curve

2011
Omega-3 fatty acids reduce hepatic steatosis and consequently attenuate ischemia-reperfusion injury following partial hepatectomy in rats.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2011, Volume: 43, Issue:12

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Choline Deficiency; Dietary Supplements; Fatty Acids, Monounsaturated; Fatty Acids, Omega-3; Fatty Liver; Hepatectomy; Liver; Male; Methionine; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha

2011
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity.
    Nutrition research (New York, N.Y.), 2011, Volume: 31, Issue:7

    Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Cysteine; Diet; Enzyme Inhibitors; Fatty Liver; Glutathione; Homeostasis; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Rats; Rats, Inbred Strains; S-Adenosylmethionine

2011
Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet.
    Molecular medicine reports, 2012, Volume: 5, Issue:1

    Topics: Alanine Transaminase; Animals; Bezafibrate; Calcium Channel Blockers; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Hypolipidemic Agents; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Nifedipine; Non-alcoholic Fatty Liver Disease; PPAR gamma; Rats; Rats, Wistar

2012
Decreased accumulation of ultrasound contrast in the liver of nonalcoholic steatohepatitis rat model.
    World journal of gastroenterology, 2011, Oct-07, Volume: 17, Issue:37

    Topics: Animals; Body Weight; Choline Deficiency; Contrast Media; Diet; Disease Models, Animal; Fatty Liver; Kupffer Cells; Leptin; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Ultrasonography

2011
Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease.
    Molecules and cells, 2011, Volume: 32, Issue:6

    Topics: Animals; Choline Deficiency; Diacylglycerol O-Acyltransferase; DNA-Binding Proteins; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Fatty Acid Synthases; Fatty Acid Transport Proteins; Fatty Acids; Fatty Liver; Fibrosis; Gene Expression; Glycerol-3-Phosphate O-Acyltransferase; Lipid Mobilization; Lipogenesis; Liver; Membrane Proteins; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphorylation; Regulatory Factor X Transcription Factors; Sterol Regulatory Element Binding Protein 1; Transcription Factor CHOP; Transcription Factors

2011
Steatotic liver: a suitable source for the isolation of hepatic progenitor cells.
    Liver international : official journal of the International Association for the Study of the Liver, 2011, Volume: 31, Issue:8

    Topics: Animals; Antigens, Differentiation; Antigens, Neoplasm; Biomarkers; Cell Adhesion Molecules; Cell Separation; Choline Deficiency; Disease Models, Animal; Epithelial Cell Adhesion Molecule; Fatty Liver; Flow Cytometry; Humans; Liver; Male; Methionine; Rats; Stem Cells; Thy-1 Antigens; Time Factors

2011
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
    Liver international : official journal of the International Association for the Study of the Liver, 2011, Volume: 31, Issue:9

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Deficiency; Disease Models, Animal; DNA, Mitochondrial; Fatty Acids, Nonesterified; Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Humans; Liver; Lysosomes; Membrane Potential, Mitochondrial; Methionine; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Stress; PPAR gamma; Rats; Rats, Inbred OLETF; Rats, Long-Evans; RNA, Messenger; Thioctic Acid; Time Factors

2011
A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation.
    Experimental cell research, 2012, Feb-01, Volume: 318, Issue:3

    Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; DNA-Binding Proteins; Fatty Liver; Feasibility Studies; Gene Expression Regulation; Liver Transplantation; Male; Methionine; Mice; Mice, SCID; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; Phenotype; Tumor Necrosis Factor-alpha

2012
Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:3

    Topics: Animals; Anticholesteremic Agents; Azetidines; Bile Acids and Salts; Biliary Tract; Biological Transport; Choline Deficiency; Diet; Ezetimibe; Fatty Liver; Glucuronosyltransferase; Intestinal Mucosa; Liver; Male; Membrane Transport Proteins; Methionine; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley

2012
Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver.
    Molecular and cellular endocrinology, 2012, Feb-26, Volume: 349, Issue:2

    Topics: Adiponectin; Aged; Animals; Bile Ducts; Choline; Diet; Fatty Liver; Female; Hepatic Stellate Cells; Hepatocytes; Humans; Kupffer Cells; Liver; Male; Methionine; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Receptors, Chemokine; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Up-Regulation

2012
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
    Life sciences, 2012, Jan-30, Volume: 90, Issue:5-6

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cytochrome P-450 CYP2E1; Diet; Disease Models, Animal; Endoplasmic Reticulum Stress; Fatty Liver; Humans; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Thiobarbituric Acid Reactive Substances; Thioctic Acid

2012
Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2012, Volume: 44, Issue:4

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline Deficiency; Cytokines; Diet; Fatty Liver; Gene Expression; Glutathione; Insulin Resistance; Isoprostanes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Methionine; Mice; Myocardium; Nitrates; Nitrites; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphorylation; Silybin; Silymarin; Statistics, Nonparametric

2012
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2012, Volume: 56, Issue:1

    Topics: Analysis of Variance; Animals; Bile Acids and Salts; Biopsy, Needle; Cells, Cultured; Diet; Disease Models, Animal; Fatty Liver; Hepatocytes; Homeostasis; Immunohistochemistry; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phospholipids; Polymerase Chain Reaction; Random Allocation

2012
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
    Nature, 2012, Feb-01, Volume: 482, Issue:7384

    Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; Colon; Cytoskeletal Proteins; Disease Models, Animal; Disease Progression; Fatty Liver; Inflammasomes; Inflammation; Interleukin-18; Male; Metagenome; Methionine; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Obesity; Receptors, Cell Surface; RNA, Ribosomal, 16S; Toll-Like Receptor 4; Toll-Like Receptor 9; Tumor Necrosis Factor-alpha

2012
Pentoxifylline attenuates methionine- and choline-deficient-diet-induced steatohepatitis by suppressing TNF-α expression and endoplasmic reticulum stress.
    Experimental diabetes research, 2012, Volume: 2012

    Topics: Alanine Transaminase; Animals; Cell Line; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fatty Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Unfolded Protein Response

2012
Identification of liver proteins altered by type 2 diabetes mellitus in obese subjects.
    Liver international : official journal of the International Association for the Study of the Liver, 2012, Volume: 32, Issue:6

    Topics: Adult; Aldehydes; Biomarkers; Biopsy; Diabetes Mellitus, Type 2; Electrophoresis, Gel, Two-Dimensional; Fatty Liver; Female; Glutathione; Humans; Liver; Methionine; Middle Aged; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Obesity, Morbid; Oxidative Stress; Protein Carbonylation; Proteins; Proteomics; Severity of Illness Index; Spain; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2012
Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.
    Journal of gastroenterology, 2012, Volume: 47, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Choline Deficiency; Cytoskeletal Proteins; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Iron; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Liver; Male; Methionine; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Real-Time Polymerase Chain Reaction; Sulfoxides; Thiocyanates

2012
Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress.
    Journal of biomedical science, 2012, Feb-29, Volume: 19

    Topics: Animals; Ascorbic Acid; Choline Deficiency; Diet; Disease Models, Animal; Ethylenediamines; Fatty Liver; Humans; Lipid Peroxidation; Methionine; Organometallic Compounds; Oxidative Stress; Rats; Salicylates

2012
Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis.
    Laboratory investigation; a journal of technical methods and pathology, 2012, Volume: 92, Issue:5

    Topics: Actins; Animals; Antigens, Differentiation; Caspase 1; Caspase 3; Choline Deficiency; Clodronic Acid; Collagen Type I; Fatty Liver; Hepatic Stellate Cells; Hepatocytes; Inflammation; Interleukin-1beta; Kupffer Cells; LIM Domain Proteins; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Proteins; Nuclear Proteins; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2012
[Mechanism of hepatocyte apoptosis in rats with liver fibrosis induced by lipogenic methionine-choline-deficient diet].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 2012, Volume: 41, Issue:2

    Topics: Animals; Apoptosis; Caspase 12; Caspase 3; Caspase 7; Caspase 9; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fatty Liver; Heat-Shock Proteins; Hepatocytes; Liver Cirrhosis; Male; Methionine; Mitogen-Activated Protein Kinases; Non-alcoholic Fatty Liver Disease; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction

2012
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet.
    American journal of physiology. Gastrointestinal and liver physiology, 2012, Volume: 303, Issue:1

    Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Cholesterol; Choline Deficiency; Diet; Endoplasmic Reticulum; Fatty Liver; Gene Expression; Inflammation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Molecular Chaperones; Phenylbutyrates; Real-Time Polymerase Chain Reaction; Stress, Physiological; Taurochenodeoxycholic Acid

2012
Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.
    Translational research : the journal of laboratory and clinical medicine, 2012, Volume: 159, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Choline Deficiency; Disease Models, Animal; Fatty Liver; Homeostasis; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Obese; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Silybin; Silymarin; Translational Research, Biomedical

2012
p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.
    Journal of hepatology, 2012, Volume: 57, Issue:4

    Topics: Animals; Apoptosis; Caspase 3; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Disease Progression; Fatty Liver; Hepatocytes; Humans; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Up-Regulation

2012
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.
    Journal of hepatology, 2012, Volume: 57, Issue:4

    Topics: Alanine Transaminase; Animals; Antimycin A; Apoptosis; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Free Radical Scavengers; Glutathione; Hepatocytes; Hydrogen Peroxide; Male; Metalloporphyrins; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitochondria, Liver; Oxidation-Reduction; Pentanoic Acids; Peroxiredoxin III; Primary Cell Culture; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Thioredoxins

2012
Altered arsenic disposition in experimental nonalcoholic fatty liver disease.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:9

    Topics: Animals; Arsenates; Arsenic Trioxide; Arsenicals; Biotransformation; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Environmental Pollutants; Fatty Liver; Kidney; Liver; Male; Methionine; Methyltransferases; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Oxides

2012
Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.
    Clinical science (London, England : 1979), 2012, Volume: 123, Issue:12

    Topics: Analysis of Variance; Animals; Arachidonic Acid; Benzofurans; Choline; Clodronic Acid; Diet, High-Fat; DNA Primers; Fatty Acids, Unsaturated; Fatty Liver; Gadolinium; Hemodynamics; Hypertension, Portal; Insulin Resistance; Kupffer Cells; Leptin; Methionine; Methoxamine; Microcirculation; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Receptors, Thromboxane A2, Prostaglandin H2; RNA, Messenger; Sulfonylurea Compounds; Thiobarbituric Acid Reactive Substances; Thromboxane A2

2012
Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis.
    Journal of hepatology, 2012, Volume: 57, Issue:5

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Choline Deficiency; Diet; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; GATA4 Transcription Factor; Glucagon-Like Peptide 1; Jejunum; Lipid Metabolism; Liver Cirrhosis; Male; Methionine; Mice; Mice, Knockout; Protein Kinases; Sterol Regulatory Element Binding Protein 1; Thiobarbituric Acid Reactive Substances; Triglycerides

2012
Glycine alleviates liver injury induced by deficiency in methionine and or choline in rats.
    European review for medical and pharmacological sciences, 2012, Volume: 16, Issue:6

    Topics: Animals; Antioxidants; Choline Deficiency; Fatty Liver; Glycine; Lipid Metabolism; Lipid Peroxidation; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley

2012
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.
    The Journal of nutrition, 2012, Volume: 142, Issue:10

    Topics: Animals; Biomarkers; Choline; Choline Deficiency; Collagen Type I; Collagen Type III; Cyclooxygenase 2; Diet; Disease Models, Animal; Fatty Liver; Fibrosis; HMGB1 Protein; Inflammation; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Quercetin; RNA, Messenger; Smad Proteins; Thiobarbituric Acid Reactive Substances; Toll-Like Receptor 4; Up-Regulation

2012
Prohibitin-1 deficiency promotes inflammation and increases sensitivity to liver injury.
    Journal of proteomics, 2012, Oct-22, Volume: 75, Issue:18

    Topics: Animals; Choline Deficiency; Fatty Liver; Inflammation; Male; Methionine; Mice; Prohibitins; Repressor Proteins; Transcriptome

2012
The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2013, Volume: 45, Issue:2

    Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Intracellular Signaling Peptides and Proteins; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha

2013
Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production.
    The Journal of biological chemistry, 2012, Nov-23, Volume: 287, Issue:48

    Topics: Animals; Chemokine CCL2; Chemokine CXCL10; Choline; Diet; Disease Models, Animal; Fatty Liver; Female; Humans; Kupffer Cells; Methionine; Mice; Mice, Inbred C57BL; Monocytes; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha

2012
Dandelion leaf extract protects against liver injury induced by methionine- and choline-deficient diet in mice.
    Journal of medicinal food, 2013, Volume: 16, Issue:1

    Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Humans; Interleukin-6; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Plant Extracts; Plant Leaves; Protective Agents; Taraxacum; Tumor Necrosis Factor-alpha

2013
Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.
    Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Choline Deficiency; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Hepatocytes; In Vitro Techniques; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Neovascularization, Pathologic; Non-alcoholic Fatty Liver Disease; Placenta Growth Factor; Pregnancy Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2013
An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis.
    International journal of experimental pathology, 2013, Volume: 94, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Diet, Fat-Restricted; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred A; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Specific Pathogen-Free Organisms; Time Factors

2013
Quercetin decreases liver damage in mice with non-alcoholic steatohepatitis.
    Basic & clinical pharmacology & toxicology, 2013, Volume: 112, Issue:6

    Topics: Animals; Antioxidants; Choline Deficiency; Comet Assay; Diet; Disease Models, Animal; DNA Damage; Fatty Liver; Lipid Peroxidation; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; Molecular Structure; Oxidative Stress; Quercetin

2013
Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice.
    Hepatology (Baltimore, Md.), 2003, Volume: 38, Issue:1

    Topics: Animal Feed; Animals; Anticholesteremic Agents; Choline Deficiency; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Fatty Acids; Fatty Liver; Female; Gene Expression Regulation, Enzymologic; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microsomes; Mixed Function Oxygenases; Pyrimidines; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Severity of Illness Index; Transcription Factors; Triglycerides

2003
Development of portal fatty liver in rats on corn diets; response to lipotropic agents.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1954, Volume: 85, Issue:2

    Topics: Animals; Choline; Diet; Fatty Liver; Lipotropic Agents; Liver Diseases; Methionine; Rats; Vitamin B 12; Zea mays

1954
[Action of lipotropic factors on hepatic steatosis in experimental hypoxia].
    Archives internationales de pharmacodynamie et de therapie, 1955, Oct-01, Volume: 103, Issue:2-3

    Topics: Choline; Fatty Liver; Humans; Hypoxia; Lipotropic Agents; Liver Diseases; Methionine

1955
[Therapy of the fatty liver with lipotropic substances].
    Medizinische Klinik, 1956, Jan-13, Volume: 51, Issue:2

    Topics: Choline; Fatty Liver; Humans; Lecithins; Lipotropic Agents; Liver Diseases; Methionine; Phosphatidylcholines

1956
[The action of various lipotropic substances on the steatogenic effects of carbon tetrachloride as a function of time].
    Archivio italiano di scienze farmacologiche, 1956, Volume: 6, Issue:3

    Topics: Carbon Tetrachloride; Choline; Fatty Liver; Lipotropic Agents; Methionine

1956
[Simultaneous administration of alcohol and lipotropic drugs in chronic alcoholics; behavior of hepatic steatosis studied by serial punch biopsies].
    Minerva medica, 1957, Feb-28, Volume: 48, Issue:17

    Topics: Alcoholics; Alcoholism; Biopsy; Choline; Fatty Liver; Humans; Lipotropic Agents; Methionine

1957
Effect of choline on the incorporation of 35S-L-methionine into liver protein of rats with fatty livers.
    Biochimica et biophysica acta, 1958, Volume: 27, Issue:3

    Topics: Animals; Choline; Fatty Liver; Liver; Methionine; Proteins; Rats

1958
Sex difference in induction of periportal fatty liver by methionine deficiency in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1958, Volume: 98, Issue:2

    Topics: Animals; Fatty Liver; Methionine; Rats; Sex Characteristics

1958
Kwashiorkor type of fatty liver in primates.
    The Journal of experimental medicine, 1958, Sep-01, Volume: 108, Issue:3

    Topics: Animals; Betaine; Body Weight; Choline; Diet; Dietary Supplements; Fatty Liver; Kwashiorkor; Lipids; Methionine; Primates; Proteins

1958
[The prevention of lipophanerosis of the liver by lipotropic substances].
    Gastroenterologia, 1958, Volume: 90, Issue:6

    Topics: Biomedical Research; Choline; Fatty Liver; Inositol; Lipotropic Agents; Liver; Methionine

1958
Turnover rates of liver protein in rats with fatty livers as measured with 35S-methionine.
    Biochimica et biophysica acta, 1959, Volume: 31, Issue:2

    Topics: Animals; Biochemical Phenomena; Fatty Liver; Liver; Methionine; Proteins; Rats

1959
[Study of the intestinal absorption of d-l-methionine in the course of hepatic steatosis].
    Revue francaise d'etudes cliniques et biologiques, 1959, Volume: 4

    Topics: Fatty Liver; Humans; Intestinal Absorption; Intestines; Liver Diseases; Methionine

1959
[Acceleration of intestinal absorption of d-l-methionine in the course of hepatic steatoses. Control of the phenomen on by the study of S 35-d-l-methionine absorption].
    Revue medicale de la Suisse romande, 1960, Volume: 80

    Topics: Fatty Liver; Humans; Intestinal Absorption; Liver Diseases; Methionine; Radioactivity; Sulfur; Sulfur Radioisotopes

1960
Experimental dietary cirrhosis.
    The Indian journal of medical research, 1962, Volume: 50

    Topics: Animals; Choline; Cystine; Diet; Fatty Liver; Humans; Liver Cirrhosis, Experimental; Methionine; Orotic Acid; Protein Deficiency; Siderosis; Vitamin E

1962
INEFFECTIVENESS OF LIPOTROPIC SUBSTANCES IN POSTIRRADIATION FATTY INFILTRATION OF THE LIVER.
    Folia biologica, 1963, Volume: 9

    Topics: Animals; Choline; Fatty Liver; Lipid Metabolism; Lipotropic Agents; Liver; Methionine; Mice; Radiation Injuries; Radiation Injuries, Experimental; Research

1963
A MARKEDLY ANTI-LIPOTROPIC ACTION OF METHIONINE.
    Nature, 1963, Nov-02, Volume: 200

    Topics: Chemical Phenomena; Chemistry; Cholesterol; Cystine; Fatty Liver; Glycerides; Lipid Metabolism; Lipotropic Agents; Liver; Methionine; Phospholipids; Protein Deficiency; Rats; Research; Valine

1963
ROLE OF IMPAIRED TRANSMETHYLATION OF EPINEPHRINE IN ETHIONINE-INDUCED HEPATIC FAT ACCUMULATION.
    Experimental and molecular pathology, 1963, Volume: 2

    Topics: Adrenalectomy; Cortisone; Epinephrine; Ethionine; Fatty Liver; Lipid Metabolism; Liver; Metabolism; Methionine; Pharmacology; Rats; Research; Toxicology; Transferases

1963
[EXPERIMENTAL DATA ON THE EFFECT OF METHIONINE IN FATTY DYSTROPHY OF THE LIVER].
    Trudy Leningradskogo sanitarno-gigienicheskogo meditsinskogo instituta, 1963, Volume: 77

    Topics: Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Liver; Hepatitis; Methionine; Rats; Research; Toxicology

1963
HOMOCYSTINURIA: AN ENZYMATIC DEFECT.
    Science (New York, N.Y.), 1964, Mar-27, Volume: 143, Issue:3613

    Topics: Amino Acids; Blood Protein Disorders; Carbon Isotopes; Child; Cystic Fibrosis; Cystinuria; Fatty Liver; Homocystinuria; Humans; Hypoproteinemia; Intellectual Disability; Ligases; Liver; Methionine; Pancreatic Neoplasms; Proteins; Psoriasis

1964
[HISTOLOGICAL STUDIES OF NUCLEIC ACIDS OF THE LIVER IN DIETARY LIVER DISORDERS. 3. RESULTS WITH A DIET OF BUCKWHEAT FLOUR WITH ADDED AMINO ACIDS].
    Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1964, Volume: 68

    Topics: Amino Acids; Arginine; Diet; Edible Grain; Fagopyrum; Fatty Liver; Flour; Histidine; Isoleucine; Leucine; Lipotropic Agents; Liver; Lysine; Methionine; Mice; Phenylalanine; Research; RNA; Threonine; Tryptophan; Valine

1964
[HISTOLOGICAL STUDY ON NUCLEIC ACIDS OF THE LIVER IN DIETARY LIVER DISORDERS. 2. THE RESULTS IN THE GROUPS FED BUCKWHEAT WITH ANTI-FATTY LIVER AGENTS].
    Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1964, Volume: 68

    Topics: Animals; Caseins; Diet; Edible Grain; Fagopyrum; Fatty Liver; Folic Acid; Liver; Methionine; Mice; Nutrition Disorders; Orotic Acid; Research; RNA; Thiamine; Thioctic Acid; Vitamin B Complex

1964
[SOME CONSIDERATIONS ON THE THERAPEUTIC USE OF METHIONINE IN HIGH DOSES].
    Gazzetta medica italiana, 1964, Volume: 123

    Topics: Fatty Liver; Hepatic Encephalopathy; Lipid Metabolism; Liver Cirrhosis; Metabolism; Methionine; Neurologic Manifestations; Pharmacology; Toxicology

1964
S35-LABELLED AMINO ACIDS IN EXPERIMENTAL LIVER DISEASE.
    The Journal of pathology and bacteriology, 1964, Volume: 88

    Topics: Amino Acids; Animals; Autoradiography; Benzene; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cystine; Ethionine; Fatty Liver; Hepatitis; Hepatitis, Animal; Liver; Methionine; Mice; Pharmacology; Research; Sulfur Isotopes

1964
FATTY LIVERS INDUCED BY AMINO ACIDS AND INFLUENCE OF OTHER AMINO ACIDS ON THEM.
    The Keio journal of medicine, 1964, Volume: 13

    Topics: Amino Acids; Arginine; Aspartic Acid; Choline; Cystine; Dietary Fats; Fatty Liver; Glutamates; Glycine; Leucine; Lipid Metabolism; Liver Function Tests; Methionine; Pharmacology; Rats; Research

1964
METHIONINE DEFICIENCY AND FATTY LIVER IN MALE AND FEMALE RATS.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 117

    Topics: Acetates; Carbon Isotopes; Cholesterol; Diet; Fatty Acids; Fatty Liver; Glycerides; Lipid Metabolism; Methionine; Phospholipids; Rats; Research; Sex

1964
RESPONSE OF THE LIVER TO PROLONGED PROTEIN DEPLETION. V. NEUTRAL GLYCERIDES AND CHOLESTEROL; PRODUCTION OF FATTY LIVERS BY CERTAIN AMINO ACIDS FED IN A PROTEIN-FREE RATION.
    The Journal of nutrition, 1965, Volume: 85, Issue:1

    Topics: Amino Acids; Cholesterol; Cystine; Dietary Fats; Dietary Proteins; Fatty Liver; Glycerides; Leucine; Liver; Methionine; Pharmacology; Phenylalanine; Phospholipids; Protein Deficiency; Proteins; Rats; Research; Valine; Zea mays

1965
HOMOCYSTINURIA: CLINICAL AND PATHOLOGICAL REVIEW OF TEN CASES.
    The Journal of pediatrics, 1965, Volume: 66

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Blood Chemical Analysis; Bone Diseases; Brain; Brain Diseases; Cardiovascular Diseases; Cerebrospinal Fluid; Child; Chromatography; Congenital Abnormalities; Eye Diseases; Facial Expression; Fatty Liver; Foot Diseases; Genetics, Medical; Homocystinuria; Humans; Hydro-Lyases; Infant; Intellectual Disability; Lens, Crystalline; Liver; Metabolism; Methionine; Urine

1965
BLOOD AMMONIA IN RATS WITH EXPERIMENTAL LIVER DAMAGE.
    Gastroenterologia, 1965, Volume: 103

    Topics: Ammonia; Antimetabolites; Blood; Chemical and Drug Induced Liver Injury; Diet; Ethionine; Fatty Liver; Hepatitis; Hepatitis A; Methionine; Pathology; Pharmacology; Rats; Research; Toxicology

1965
[FURTHER STUDIES ON THE PREVENTION OF THE ACUTE FATTY LIVER INDUCED BY ETHIONINE. 2. EFFECTS OF METHIONINE AND N-CARBOBENZOXY-L-GLUTAMYLCHOLINE UPON ESTERASE ACTION AND HISTOLOGICAL ASPECTS OF FAT IN ACUTE FATTY LIVER INDUCED BY ETHIONINE].
    Naika hokan. Japanese archives of internal medicine, 1965, Volume: 12

    Topics: Amino Acids; Biomedical Research; Esterases; Ethionine; Fatty Liver; Methionine; Rats; Research; Toxicology

1965
THE LIPOTROPIC ACTION OF COLD. 2. THE INFLUENCE OF COLD AND CHOLINE DEFICIENCY ON SERUM LIPIDS OF RATS AT DIFFERENT INTAKES OF DIETARY METHIONINE.
    Canadian journal of physiology and pharmacology, 1965, Volume: 43

    Topics: Cholesterol; Choline; Choline Deficiency; Cold Temperature; Diet; Fatty Liver; Glycerides; Lipids; Lipotropic Agents; Methionine; Phospholipids; Rats; Research; Vitamin B Deficiency

1965
THE EFFECTS OF CHOLINE AND RELATED COMPOUNDS ON THE GROWTH AND DEVELOPMENT OF DROSOPHILA MELANOGASTER.
    The Journal of experimental zoology, 1965, Volume: 158

    Topics: Amino Acids; Amino Alcohols; Ammonium Compounds; Animals; Betaine; Carnitine; Chemical Phenomena; Chemistry; Choline; Diet; Drosophila; Drosophila melanogaster; Fatty Liver; Folic Acid; Growth and Development; Meat; Metamorphosis, Biological; Methionine; Neurospora; Pharmacology; Poultry; Quaternary Ammonium Compounds; Rats; Research; Salts; Vitamin B Complex

1965
Fatty liver of portal type: effects of choline, methionine, and vitamin B12.
    The Journal of nutrition, 1955, May-10, Volume: 56, Issue:1

    Topics: Choline; Fatty Liver; Liver Diseases; Methionine; Vitamin B 12; Vitamin B Complex

1955
[Relation between fatty liver due to cystine and methionine and glycine].
    The Keio journal of medicine, 1962, Volume: 39

    Topics: Cystine; Fabaceae; Fatty Liver; Glycine; Humans; Liver Diseases; Methionine

1962
Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies.
    Journal of gastroenterology and hepatology, 2003, Volume: 18, Issue:11

    Topics: Alanine Transaminase; Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Female; Lipid Peroxidation; Liver; Male; Malnutrition; Methionine; Mice; Mice, Inbred C57BL; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Sex Factors; Species Specificity

2003
Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.
    Journal of hepatology, 2003, Volume: 39, Issue:5

    Topics: Animals; Choline; Diet; Fatty Liver; Gene Expression; Hepatocytes; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Methionine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta; Up-Regulation

2003
The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance.
    Journal of hepatology, 2004, Volume: 40, Issue:1

    Topics: Alanine Transaminase; Animals; Blood Glucose; Choline Deficiency; Deficiency Diseases; Fasting; Fatty Liver; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Male; Methionine; Mice; Mice, Inbred Strains

2004
Sex differences in choline-deficient diet-induced steatohepatitis in mice.
    Experimental biology and medicine (Maywood, N.J.), 2004, Volume: 229, Issue:2

    Topics: Animal Feed; Animals; Apoptosis; Body Weight; Cell Differentiation; Choline Deficiency; Fatty Liver; Female; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Organ Size; Sex Factors; Transaminases; Triglycerides

2004
[Effect of methionine and choline on the cholestero overload of the liver in experimental steatosis of the liver in the rat].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1950, Volume: 144, Issue:11-12

    Topics: Animals; Choline; Fatty Liver; Liver; Methionine; Rats

1950
Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:1

    Topics: Alanine Transaminase; Animals; Choline Deficiency; Collagen Type I; Diet; Fatty Liver; Female; Hepatocytes; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred Strains; Mice, Knockout; Molecular Weight; Organ Size; Osteopontin; Oxidative Stress; Sialoglycoproteins; Triglycerides; Tumor Necrosis Factor-alpha; Up-Regulation

2004
Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:5

    Topics: Animals; Cell Line; Choline Deficiency; Deficiency Diseases; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Liver; Female; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Osteopontin; Receptors, Cell Surface; Receptors, Leptin; Sialoglycoproteins

2004
Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice.
    Hepatology (Baltimore, Md.), 2004, Volume: 40, Issue:2

    Topics: Animals; Cell Adhesion; Choline Deficiency; Deficiency Diseases; Diet; Dietary Fats; Fatty Liver; Fibrosis; Leukocytes; Lipid Metabolism; Lipid Peroxides; Liver; Liver Circulation; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Microcirculation; Microscopy, Electron; Oxidative Stress; Phagocytes; Vascular Patency

2004
[Effect of lipotropic substances upon blood and liver lipoids in experimental fatty liver and in liver cirrhosis in man].
    Klinische Wochenschrift, 1950, Aug-01, Volume: 28, Issue:29-30

    Topics: Choline; Fatty Liver; Lipotropic Agents; Liver; Liver Cirrhosis; Methionine

1950
Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet.
    Journal of hepatology, 2004, Volume: 41, Issue:4

    Topics: Alanine Transaminase; Animals; Choline Deficiency; Deficiency Diseases; Diet; Disease Progression; Fatty Liver; Female; Glutathione; Hepatitis; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Pentoxifylline; Phosphodiesterase Inhibitors; RNA, Messenger; Triglycerides; Tumor Necrosis Factor-alpha

2004
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice.
    Journal of hepatology, 2004, Volume: 41, Issue:6

    Topics: Animals; Chemokine CCL2; Choline Deficiency; Collagen Type I; Curcumin; Cyclooxygenase 2; Deficiency Diseases; Diet; Enzyme Inhibitors; Fatty Liver; Female; Hepatitis; Inflammation Mediators; Intercellular Adhesion Molecule-1; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Severity of Illness Index; Transcription Factor AP-1

2004
Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
    The Journal of biological chemistry, 2005, Mar-18, Volume: 280, Issue:11

    Topics: Adenoviridae; Animals; Blotting, Northern; Blotting, Western; Cell Line; Choline; Cytochrome P-450 CYP2E1; DNA-Binding Proteins; Down-Regulation; Fatty Liver; Forkhead Box Protein O1; Forkhead Transcription Factors; Glucose; Glutathione Peroxidase; Glycogen Synthase Kinase 3; Hepatitis; Hepatocytes; Humans; Immunoprecipitation; Insulin; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Nerve Tissue Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; RNA; Serine; Signal Transduction; Subcellular Fractions; Time Factors; Transcription Factors; Tyrosine; Up-Regulation

2005
Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet.
    American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 288, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Choline Deficiency; Cytochrome P-450 CYP2E1; Diet; Fatty Liver; Male; Methionine; Mice; Mice, Transgenic; Prealbumin

2005
A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes.
    The Journal of nutrition, 2005, Volume: 135, Issue:3

    Topics: Animals; Betaine; Disease Models, Animal; Ethanol; Fatty Liver; Hepatocytes; Male; Methionine; Methyltransferases; Microsomes, Liver; Phosphatidylethanolamine N-Methyltransferase; Rats; Rats, Wistar; S-Adenosylmethionine

2005
Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice.
    Gut, 2006, Volume: 55, Issue:3

    Topics: Animals; Apoptosis; Cell Adhesion Molecules; Choline Deficiency; Fatty Liver; Gene Expression Regulation; Kupffer Cells; Liver Cirrhosis, Experimental; Male; Methionine; Mice; Mice, Knockout; Mitochondria, Liver; Mutation; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha

2006
Metabolic profiling of livers and blood from obese Zucker rats.
    Journal of hepatology, 2006, Volume: 44, Issue:5

    Topics: Animals; Betaine; Energy Metabolism; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Fatty Liver; Glutathione; Glycolysis; Lipid Peroxidation; Liver; Magnetic Resonance Spectroscopy; Male; Methionine; Mitochondria; Obesity; Rats; Rats, Zucker; Reperfusion Injury; Triglycerides

2006
NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis.
    Gastroenterology, 2005, Volume: 129, Issue:5

    Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Inflammation Mediators; Intercellular Adhesion Molecule-1; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NF-kappa B; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Tumor Necrosis Factor-alpha

2005
JNK1 but not JNK2 promotes the development of steatohepatitis in mice.
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:1

    Topics: Adiponectin; Alanine Transaminase; Animals; Apoptosis; Choline Deficiency; Enzyme Activation; Fatty Liver; Female; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Triglycerides

2006
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet.
    Journal of hepatology, 2006, Volume: 44, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biomarkers; Choline; Chromatography, High Pressure Liquid; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Heterozygote; Methionine; Mice; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Severity of Illness Index; Up-Regulation

2006
Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium.
    American journal of physiology. Gastrointestinal and liver physiology, 2006, Volume: 291, Issue:1

    Topics: Animals; Cell Line; Choline Deficiency; Culture Media; Fatty Liver; Hepatocytes; Methionine; Mice; Osteopontin; Phosphatidylinositol 3-Kinases; Sialoglycoproteins; Transaminases

2006
Glutathione-enhancing agents protect against steatohepatitis in a dietary model.
    Journal of biochemical and molecular toxicology, 2006, Volume: 20, Issue:1

    Topics: Animals; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Food, Formulated; Inflammation; Lipotropic Agents; Male; Methionine; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Thiazoles; Transaminases

2006
COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator.
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:4

    Topics: Animals; Choline Deficiency; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diet; Enzyme Induction; Fatty Liver; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-6; Lipogenesis; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; PPAR alpha; Tumor Necrosis Factor-alpha

2006
Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet.
    European journal of pharmacology, 2006, Apr-24, Volume: 536, Issue:1-2

    Topics: Acyl-CoA Oxidase; Alanine Transaminase; Animals; Bezafibrate; Carnitine O-Palmitoyltransferase; Cholesterol, HDL; Choline; Diet; Dose-Response Relationship, Drug; Fatty Acid-Binding Proteins; Fatty Liver; Gene Expression; Interleukin-6; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Peroxisome Proliferator-Activated Receptors; PPAR delta; RNA, Messenger; Thiazoles; Thiobarbituric Acid Reactive Substances; Transforming Growth Factor beta; Transforming Growth Factor beta1; Triglycerides

2006
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Apr-25, Volume: 103, Issue:17

    Topics: Allosteric Regulation; Animals; Carcinoma, Hepatocellular; Cell Line; Cystathionine beta-Synthase; Enzyme Stability; Fatty Liver; Gene Silencing; Humans; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; Mice; Mice, Knockout; Oxidation-Reduction; Recombinant Proteins; S-Adenosylmethionine

2006
Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency.
    Journal of gastroenterology and hepatology, 2006, Volume: 21, Issue:1 Pt 1

    Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Fatty Liver; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Rats; Triglycerides; Tumor Necrosis Factor-alpha

2006
The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis.
    Gut, 2007, Volume: 56, Issue:4

    Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Constitutive Androstane Receptor; Diet; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Knockout; Organ Size; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Translocation, Genetic

2007
Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis.
    Liver international : official journal of the International Association for the Study of the Liver, 2006, Volume: 26, Issue:8

    Topics: Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Methionine; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Quantitative Trait Loci

2006
Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease.
    Liver international : official journal of the International Association for the Study of the Liver, 2006, Volume: 26, Issue:10

    Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Fatty Liver; Female; Hydroxyproline; Iron Overload; Lipid Peroxidation; Liver; Methionine; Organ Size; Rats; Rats, Inbred F344

2006
NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis.
    Journal of hepatology, 2007, Volume: 46, Issue:2

    Topics: Animals; Chemokine CCL2; Chemokine CCL4; Choline; Choline Deficiency; Cyclooxygenase 2; Diet; Disease Models, Animal; Fatty Liver; Female; Gene Expression Regulation; Hepatitis; Intercellular Adhesion Molecule-1; Liver; Macrophage Inflammatory Proteins; Membrane Glycoproteins; Methionine; Mice; Mice, Mutant Strains; NADPH Oxidase 2; NADPH Oxidases; NF-kappa B; Oxidative Stress; RNA, Messenger; Tumor Necrosis Factor-alpha

2007
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.
    Gastroenterology, 2007, Volume: 132, Issue:1

    Topics: Animal Feed; Animals; Choline; Collagen Type I; Collagen Type I, alpha 1 Chain; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, Animal; Fatty Liver; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Liver; Male; Methionine; Obesity; Pioglitazone; Plasminogen Activator Inhibitor 1; PPAR gamma; Rats; Rats, Inbred OLETF; Rats, Long-Evans; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Thiazolidinediones; Transforming Growth Factor beta; Up-Regulation

2007
Choline cannot be replaced by propanolamine in mice.
    Biochimica et biophysica acta, 2007, Volume: 1771, Issue:4

    Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Liver; Methionine; Mice; Mice, Inbred C57BL; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Propanolamines; Triglycerides

2007
Yo jyo hen shi ko, a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet.
    Liver international : official journal of the International Association for the Study of the Liver, 2007, Volume: 27, Issue:2

    Topics: Animals; Biomarkers; Body Weight; Choline Deficiency; Diet; Dietary Fats; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fatty Liver; Hepatitis; Lipids; Liver; Male; Methionine; Mice; Mice, Obese; Oxidative Stress; Transaminases

2007
Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis.
    Biochemical and biophysical research communications, 2007, Apr-27, Volume: 356, Issue:1

    Topics: Animals; Benzamides; Cholesterol; Choline Deficiency; Cyclooxygenase 2; Diet; Enzyme Activation; Fatty Liver; Gene Expression; Hypolipidemic Agents; Intercellular Adhesion Molecule-1; Interleukin-6; Lipogenesis; Lipoprotein Lipase; Lipoproteins, HDL; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Organophosphorus Compounds; PPAR gamma; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha

2007
The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population.
    Journal of hepatology, 2007, Volume: 46, Issue:5

    Topics: Adult; Alleles; Asian People; DNA Primers; Fatty Liver; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Japan; Male; Methionine; Middle Aged; Phosphatidylethanolamine N-Methyltransferase; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Valine

2007
Preservation of steatotic livers: a comparison between cold storage and machine perfusion preservation.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2007, Volume: 13, Issue:4

    Topics: Animals; Cold Temperature; Fatty Liver; Humans; Liver Function Tests; Liver Transplantation; Male; Methionine; Models, Animal; Organ Preservation; Perfusion; Rats; Rats, Wistar; Reperfusion; Tissue Donors

2007
Protective effect of soy isoflavones and activity levels of plasma paraoxonase and arylesterase in the experimental nonalcoholic steatohepatitis model.
    Digestive diseases and sciences, 2007, Volume: 52, Issue:8

    Topics: Animals; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Choline Deficiency; Disease Models, Animal; Fatty Liver; Glycine max; Hepatitis; Isoflavones; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Rats

2007
CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:5

    Topics: Acute-Phase Reaction; Animals; Body Weight; CCAAT-Enhancer-Binding Protein-beta; Choline Deficiency; Cytochrome P-450 CYP2E1; Diet; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum; Eukaryotic Initiation Factor-2; Fatty Liver; Inflammation; JNK Mitogen-Activated Protein Kinases; Lipase; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Transcription Factor CHOP; Tumor Necrosis Factor-alpha

2007
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:6

    Topics: Adiponectin; Animal Feed; Animals; Blood Glucose; Choline; Cytochrome P-450 CYP2E1; Diacylglycerol O-Acyltransferase; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes; Insulin; Lipid Peroxidation; Liver Cirrhosis; Male; Methionine; Mice; Mice, Mutant Strains; Obesity; Oligoribonucleotides, Antisense; Oxidative Stress; Triglycerides; Tumor Necrosis Factor-alpha

2007
Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2007, Volume: 45, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animal Feed; Animals; Choline; Connective Tissue Growth Factor; Fatty Liver; Imidazoles; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Liver Cirrhosis; Male; Methionine; Oxidative Stress; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Tetrazoles; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2007
Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury.
    Journal of lipid research, 2007, Volume: 48, Issue:8

    Topics: Animals; Chemical and Drug Induced Liver Injury; Choline; Choline Deficiency; Diet; Fatty Acids, Unsaturated; Fatty Liver; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C3H

2007
Role of adipocytokines in hepatic fibrogenesis.
    Journal of gastroenterology and hepatology, 2007, Volume: 22 Suppl 1

    Topics: Adiponectin; Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Kupffer Cells; Leptin; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Oxidative Stress; Transforming Growth Factor beta1; Up-Regulation

2007
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis.
    Journal of hepatology, 2007, Volume: 47, Issue:4

    Topics: Animals; Choline Deficiency; Clodronic Acid; Collagen Type I; Collagen Type I, alpha 1 Chain; Diet; Endotoxemia; Fatty Liver; Hepatitis, Animal; Kupffer Cells; Lymphotoxin-alpha; Methionine; Mice; Mice, Mutant Strains; PPAR alpha; Signal Transduction; Toll-Like Receptor 4; Triglycerides

2007
Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.
    Gastroenterology, 2007, Volume: 133, Issue:2

    Topics: Adult; Aged; Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Clorgyline; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Humans; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Severity of Illness Index; Tryptophan Hydroxylase; Up-Regulation

2007
Thioacetamide-induced hepatic damage in a rat nutritional model of steatohepatitis.
    Journal of medicine, 2003, Volume: 34, Issue:1-6

    Topics: Animals; Choline; Cytochrome P-450 CYP2E1; Fatty Liver; Hepatitis; Liver; Male; Methionine; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Thioacetamide

2003
Methionine deficiency and hepatic injury in a dietary steatohepatitis model.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:3

    Topics: Animals; Choline Deficiency; Fatty Liver; Gene Expression; Hepatitis, Animal; Liver; Male; Methionine; Rats; Rats, Sprague-Dawley

2008
Not all models of fatty liver are created equal: understanding mechanisms of steatosis development is important.
    Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:9

    Topics: Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Fatty Liver, Alcoholic; Humans; Methionine; Rats

2007
Essential pathogenic and metabolic differences in steatosis induced by choline or methione-choline deficient diets in a rat model.
    Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:9

    Topics: Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Insulin; Lipids; Liver; Male; Methionine; Oxidative Stress; Rats; Rats, Wistar

2007
Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis.
    Journal of biochemical and molecular toxicology, 2007, Volume: 21, Issue:4

    Topics: Animal Feed; Animals; Antioxidants; Catalytic Domain; Choline Deficiency; Diet; Disease Models, Animal; Epoxide Hydrolases; Fatty Liver; Glutamate-Cysteine Ligase; Heme Oxygenase (Decyclizing); Male; Methionine; NAD(P)H Dehydrogenase (Quinone); Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Up-Regulation

2007
S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet.
    Alcoholism, clinical and experimental research, 2007, Volume: 31, Issue:11

    Topics: Animals; Body Weight; Disease Models, Animal; Ethanol; Fatty Liver; Female; Folic Acid; Folic Acid Deficiency; Linear Models; Liver; Liver Diseases, Alcoholic; Male; Methionine; Necrosis; Oxidative Stress; S-Adenosylmethionine; Swine; Swine, Miniature

2007
Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation.
    Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:2

    Topics: Animals; Choline Deficiency; Dietary Fats, Unsaturated; Disease Models, Animal; Down-Regulation; Fatty Acids; Fatty Acids, Omega-3; Fatty Liver; Female; Fish Oils; Gene Expression; Lipid Peroxides; Lipogenesis; Lipolysis; Liver; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha

2008
Interstrain differences in susceptibility to non-alcoholic steatohepatitis.
    Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:2

    Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Disease Susceptibility; Fatty Liver; Gene Expression; Lipid Metabolism; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Organ Size; RNA, Messenger; Species Specificity

2008
The influence of methionine, selenomethionine, and vitamin E on liver metabolic pathways and steatosis in high-cholesterol fed rabbits.
    Biological trace element research, 2007,Winter, Volume: 120, Issue:1-3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cholesterol; Cholesterol, Dietary; Fatty Liver; Fructose-Bisphosphate Aldolase; Glutamate Dehydrogenase; L-Iditol 2-Dehydrogenase; L-Lactate Dehydrogenase; Liver; Male; Methionine; Rabbits; Selenomethionine; Triglycerides; Vitamin E

2007
Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse.
    World journal of gastroenterology, 2007, Nov-14, Volume: 13, Issue:42

    Topics: Animals; Apoptosis; Choline Deficiency; Constitutive Androstane Receptor; Fatty Acids; Fatty Liver; Inflammation; Leukotriene B4; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha; Pyridines; Receptors, Cytoplasmic and Nuclear; Transcription Factors

2007
Mitochondrial adaptations to steatohepatitis induced by a methionine- and choline-deficient diet.
    American journal of physiology. Endocrinology and metabolism, 2008, Volume: 294, Issue:1

    Topics: Adaptation, Physiological; Animal Feed; Animals; Choline; Choline Deficiency; Energy Metabolism; Fatty Liver; Hepatitis; Interleukin-6; Male; Malnutrition; Methionine; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha

2008
The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury.
    Biochemical pharmacology, 2008, Feb-15, Volume: 75, Issue:4

    Topics: Animals; Body Weight; Choline Deficiency; Diet; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; Gene Expression; Liver; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred Strains; Organ Size; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2008
Effects of rosiglitazone on methionine-choline deficient diet-induced nonalcoholic steatohepatitis.
    Hepatology (Baltimore, Md.), 2007, Volume: 46, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline; Diet; Disease Models, Animal; Fatty Liver; Liver; Methionine; Mice; Mitochondria, Liver; Rosiglitazone; Thiazolidinediones

2007
The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet.
    Inflammation, 2008, Volume: 31, Issue:2

    Topics: Actins; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Aspartate Aminotransferases; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Hepatitis; Infliximab; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Male; Malondialdehyde; Methionine; Necrosis; Rats; Time Factors; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2008
Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo.
    Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:2

    Topics: Animals; Capsules; Cells, Cultured; Choline Deficiency; Fatty Liver; Flavonoids; Glucosides; Hepatocytes; Herbal Medicine; Hydrolyzable Tannins; Male; Methionine; Mice; Mice, Inbred C57BL; Phyllanthus; Polysaccharides; Rats; Rats, Wistar

2008
Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet.
    Journal of lipid research, 2008, Volume: 49, Issue:5

    Topics: Adipose Tissue; Animals; Body Weight; Choline Deficiency; Chromatography, Liquid; Dietary Fats; Fatty Liver; Lipids; Lipoproteins, VLDL; Liver; Methionine; Mice; Models, Biological; Organ Size; Polymerase Chain Reaction; RNA; Skin; Viscera

2008
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:10

    Topics: Animals; Choline; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Food, Formulated; Glutathione; Hepatitis; Homeostasis; Lipid Metabolism; Liver; Methionine; Mice; Mice, Mutant Strains; Mice, Obese; Obesity; S-Adenosylmethionine

2008
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.
    Hepatology (Baltimore, Md.), 2008, Volume: 47, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Glycine N-Methyltransferase; Histones; Janus Kinases; Liver Cirrhosis; Liver Neoplasms; Male; Methionine; Mice; Mice, Knockout; Promoter Regions, Genetic; ras Proteins; S-Adenosylmethionine; Signal Transduction; STAT Transcription Factors; Suppressor of Cytokine Signaling Proteins; Transaminases; Tumor Suppressor Proteins

2008
Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis.
    Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:12

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Carnosine; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Hepatic Stellate Cells; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Methionine; Mice; Mice, Inbred C57BL; Organometallic Compounds; RNA, Messenger; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha; Zinc Compounds

2008
Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver.
    Alcoholism, clinical and experimental research, 2008, Volume: 32, Issue:6

    Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Diet; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; Folic Acid; Gene Expression; Homocysteine; Humans; Methionine; Mice; Mice, Transgenic; Recombinant Proteins

2008
Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects.
    European journal of pharmacology, 2008, Jul-07, Volume: 588, Issue:2-3

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Choline Deficiency; Disease Models, Animal; Fatty Acids; Fatty Liver; Imidazoles; Insulin Resistance; Liver Cirrhosis, Experimental; Male; Methionine; Oxidative Stress; Rats; Rats, Long-Evans; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Tetrazoles; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2008
Effects of L-asparagine and related compounds on the hepatic fatty infiltration and necrosis induced by ethionine and carbon tetrachloride.
    Biochemical pharmacology, 1967, Volume: 16, Issue:6

    Topics: Animals; Asparagine; Aspartic Acid; Carbon Tetrachloride; Chromatography, Gas; Ethionine; Fatty Acids; Fatty Liver; Female; Glutamine; Glycerides; Ketoglutaric Acids; Liver; Methionine; Necrosis; Rats; Triglycerides

1967
Vitamin B12, choline and related substances in dietary hepatic injury in rats.
    The Journal of nutrition, 1967, Volume: 92, Issue:4

    Topics: Amino Acids; Animals; Body Weight; Choline; Cystine; Diet; Fatty Liver; Growth; Homocystine; Lipid Metabolism; Liver; Male; Methionine; Organ Size; Rats; Vitamin B 12

1967
The influence of testosterone on the induction of fatty liver by methionine deficiency.
    Laboratory investigation; a journal of technical methods and pathology, 1967, Volume: 16, Issue:6

    Topics: Amino Acids; Animals; Castration; Choline; Deficiency Diseases; Diet; Fatty Liver; Female; Glutamates; Lipid Metabolism; Liver; Liver Glycogen; Male; Methionine; Organ Size; Proteins; Rats; Testosterone

1967
Lipid transport in experimental dietary hepatic injury in rats.
    The Journal of nutrition, 1967, Volume: 93, Issue:4

    Topics: Animals; Biological Transport; Cholesterol; Choline; Dietary Proteins; Fats, Unsaturated; Fatty Liver; Homocystine; Lipid Metabolism; Lipoproteins; Liver; Male; Methionine; Phospholipids; Rats; Vitamin B 12

1967
Fatty liver due to disproportionally added methionine to a low soybean diet and lipotropic action of phosphatides in rats.
    The Journal of nutrition, 1980, Volume: 110, Issue:3

    Topics: Animals; Apolipoproteins; Biological Transport; Cholesterol; Fatty Liver; Glycine max; Insulin; Lipid Metabolism; Methionine; Phosphatidylcholines; Phospholipids; Plant Proteins, Dietary; Rats; Triglycerides

1980
Comparative effects of S-methylmethionine (vitamin U) and methionine on choline-deficient fatty liver in rats.
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:1

    Topics: Animals; Body Weight; Choline Deficiency; Diet; Fatty Liver; Male; Methionine; Organ Size; Rats; Time Factors; Vitamin U; Vitamins

1980
In vivo microscopic observation of fatty liver grafts after reperfusion.
    Transplantation proceedings, 1994, Volume: 26, Issue:4

    Topics: Animals; Choline Deficiency; Endothelium, Vascular; Fatty Liver; Graft Survival; Liver; Liver Circulation; Liver Transplantation; Methionine; Microcirculation; Organ Preservation; Rats; Rats, Inbred ACI; Reperfusion; Time Factors; Transplantation, Isogeneic

1994
A rat fatty liver transplant model.
    Transplantation, 1993, Volume: 55, Issue:4

    Topics: Animals; Choline Deficiency; Chromatography, Gas; Diet; Disease Models, Animal; Fatty Liver; Graft Survival; Lipids; Liver; Liver Diseases; Liver Transplantation; Male; Methionine; Necrosis; Postoperative Period; Rats; Rats, Inbred ACI; Time Factors

1993
Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
    Carcinogenesis, 1996, Volume: 17, Issue:3

    Topics: Acetophenones; Animals; Aspirin; Choline; Choline Deficiency; Cyclooxygenase Inhibitors; Fatty Liver; gamma-Glutamyltransferase; Glutathione Transferase; Lipoxygenase Inhibitors; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Masoprocol; Methionine; Oxidative Stress; Phospholipases A; Phospholipases A2; Precancerous Conditions; Quercetin; Rats; Rats, Inbred F344; Time Factors

1996
The effects of N-acetylcysteine and anti-intercellular adhesion molecule-1 monoclonal antibody against ischemia-reperfusion injury of the rat steatotic liver produced by a choline-methionine-deficient diet.
    Hepatology (Baltimore, Md.), 1997, Volume: 26, Issue:3

    Topics: Acetylcysteine; Acid Phosphatase; Alanine Transaminase; Animals; Antibodies, Monoclonal; Aspartate Aminotransferases; Bile; Choline Deficiency; Fatty Liver; In Vitro Techniques; Intercellular Adhesion Molecule-1; Ischemia; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Methionine; Microscopy, Electron; Neutrophils; Perfusion; Rats; Rats, Wistar; Reperfusion Injury

1997
S-adenosyl-L-methionine attenuates ischemia-reperfusion injury of steatotic livers.
    Transplantation proceedings, 1998, Volume: 30, Issue:7

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Fatty Liver; Glutathione; Glutathione Disulfide; Ischemia; L-Lactate Dehydrogenase; Liver; Male; Methionine; Mitochondria, Liver; Rats; Rats, Wistar; Reperfusion Injury; S-Adenosylmethionine

1998
N-acetylcysteine and anti-ICAM-1 monoclonal antibody reduce ischemia-reperfusion injury of the steatotic rat liver.
    Transplantation proceedings, 1998, Volume: 30, Issue:7

    Topics: Acetylcysteine; Adenosine; Allopurinol; Animals; Antibodies, Monoclonal; Choline Deficiency; Fatty Liver; Glutathione; Insulin; Intercellular Adhesion Molecule-1; Ischemia; Liver; Male; Methionine; Organ Preservation; Organ Preservation Solutions; Raffinose; Rats; Rats, Wistar; Reperfusion Injury

1998
Does steatohepatitis impair liver regeneration? A study in a dietary model of non-alcoholic steatohepatitis in rats.
    Journal of gastroenterology and hepatology, 1999, Volume: 14, Issue:2

    Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Choline Deficiency; Fatty Liver; Follow-Up Studies; Hepatectomy; Hepatitis, Animal; Liver Regeneration; Male; Methionine; Rats; Rats, Wistar

1999
Effects of fat and methionine hydroxy analog on prevention or alleviation of fatty liver induced by feed restriction.
    Journal of dairy science, 1999, Volume: 82, Issue:12

    Topics: Animals; Blood Glucose; Cattle; Dietary Fats; Energy Metabolism; Fatty Acids, Nonesterified; Fatty Liver; Female; Food Deprivation; Hydroxylation; Liver; Methionine; Pregnancy; Triglycerides

1999
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
    The Journal of clinical investigation, 2000, Volume: 105, Issue:8

    Topics: Animals; Catalysis; Choline Deficiency; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Fatty Liver; Female; Gene Expression; Hepatitis; Lipid Peroxidation; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microsomes; Mixed Function Oxygenases; Weight Loss

2000
Dietary cystine and liver triacylglycerols in rats: effects of dietary lysine and threonine.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 1998, Volume: 119, Issue:2

    Topics: Amino Acids; Animals; Cystine; Fatty Liver; Glutens; Liver; Lysine; Male; Methionine; Organ Size; Rats; Rats, Wistar; Threonine; Triglycerides; Triticum

1998
Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.
    Journal of hepatology, 2002, Volume: 36, Issue:5

    Topics: Animal Feed; Animals; Blotting, Western; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cholesterol; Choline; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Disease Models, Animal; Fatty Liver; Hepatectomy; Liver; Liver Regeneration; Male; Methionine; Organ Size; Orotic Acid; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Rats, Zucker; Triglycerides

2002
Sex difference in the development of fatty liver by orotic acid.
    Japanese journal of pharmacology, 1975, Volume: 25, Issue:3

    Topics: Acetates; Animals; Fatty Liver; Female; Lipoproteins, LDL; Liver; Male; Methionine; Orotic Acid; Phosphatidylcholines; Proteins; Rats; Sex Factors

1975
[Results of oral methionine loads in normal subjects and patients with liver diseases using an analyzer short program].
    Acta biologica et medica Germanica, 1977, Volume: 36, Issue:10

    Topics: Adolescent; Adult; Amino Acids; Chromatography, Gas; Fatty Liver; Female; Humans; Liver Cirrhosis; Liver Diseases; Male; Methionine; Middle Aged; Time Factors

1977
Uptake of adenosylmethionine and related sulfur compounds by isolated rat liver.
    FEBS letters, 1978, Jun-15, Volume: 90, Issue:2

    Topics: Biological Transport; Dinitrophenols; Fatty Liver; Kinetics; Liver; Methionine; S-Adenosylmethionine

1978
The effect of methionine, thiouracil, dienestrol diacetate and thyroprotein on the development and prevention of fatty liver in pullets.
    Poultry science, 1975, Volume: 54, Issue:3

    Topics: Adipose Tissue; Animal Feed; Animals; Caseins; Chickens; Dienestrol; Eggs; Fatty Liver; Female; Hematoma; Hemorrhage; Iodoproteins; Lipid Metabolism; Liver; Liver Diseases; Methionine; Phenols; Phosphorus; Poultry Diseases; Syndrome; Thiouracil

1975
Fatty liver induced by methionine supplementation of low protein diet: effect of inositol supply.
    The Journal of nutrition, 1991, Volume: 121, Issue:7

    Topics: Animals; Dietary Proteins; Fatty Liver; Inositol; Methionine; Rats

1991
Hepatic content of S-adenosylmethionine, S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability.
    The Journal of nutrition, 1989, Volume: 119, Issue:10

    Topics: Animals; Biomarkers; Choline Deficiency; Cysteine; Diet; Fatty Liver; Folic Acid Deficiency; Glutathione; Homocysteine; Lipids; Liver; Male; Methionine; Methylation; Niacinamide; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine

1989
A comparison of the response of woodchucks and rats to variations in dietary lipotrope and protein content.
    The Journal of nutrition, 1986, Volume: 116, Issue:10

    Topics: Animals; Body Weight; Choline Deficiency; Diet; Fatty Liver; Folic Acid Deficiency; Male; Marmota; Methionine; Protein Deficiency; Rats; Rats, Inbred F344; Sciuridae; Species Specificity; Vitamin B 12 Deficiency

1986
Effect of dietary protein and amino acids in a choline-deficient diet on lipid accumulation in rat liver.
    The Journal of nutrition, 1971, Volume: 101, Issue:6

    Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Body Composition; Body Weight; Caseins; Choline Deficiency; Depression, Chemical; Diet Therapy; Dietary Proteins; Fatty Liver; Female; Glutamates; Lipid Metabolism; Lipotropic Agents; Liver; Metabolism; Methionine; Ovalbumin; Rats; Serine

1971
Animal model: fatty liver and cirrhosis in lipotrope-deficient male rats.
    The American journal of pathology, 1973, Volume: 73, Issue:3

    Topics: Animals; Choline Deficiency; Deficiency Diseases; Diet; Disease Models, Animal; Fatty Liver; Humans; Lipotropic Agents; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Rats; Vitamin B 12 Deficiency

1973
Fatty liver and kidney syndrome in chicks. Effects on liver and kidney of diets causing the syndrome.
    Research in veterinary science, 1974, Volume: 17, Issue:2

    Topics: Animals; Aspergillus; Aspergillus flavus; Aspergillus fumigatus; Body Weight; Calcium, Dietary; Chickens; Cystine; Diet; Dietary Proteins; Ethers; Fatty Liver; Female; Kidney; Kidney Diseases; Lipid Metabolism; Liver; Male; Methionine; Organ Size; Poultry Diseases

1974
[Hepatic steatosis and cholesterolemia in the domestic duckling in the course of protein malnutrition on a rice diet].
    Canadian journal of comparative medicine and veterinary science, 1965, Volume: 29, Issue:11

    Topics: Animals; Arginine; Deficiency Diseases; Fatty Liver; Glutamine; Glycine; Growth; Histidine; Hypercholesterolemia; Isoleucine; Leucine; Lysine; Methionine; Oryza; Phenylalanine; Poultry Diseases; Protein Deficiency; Threonine; Tryptophan; Valine

1965
Vitamin B 12 and methionine metabolism in the Buffalo rat liver and Morris 5123 hepatoma.
    Laboratory investigation; a journal of technical methods and pathology, 1972, Volume: 27, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Choline Deficiency; Fatty Liver; Folic Acid; Homocystine; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Methionine; Methylation; Neoplasms, Experimental; Nutrition Disorders; Rats; Vitamin B 12; Vitamin B 12 Deficiency

1972
Effect of methionine on liver lipid content and lipid metabolism of rats fed a protein-free diet.
    The Journal of nutrition, 1973, Volume: 103, Issue:1

    Topics: Animal Nutritional Physiological Phenomena; Animals; Blood Proteins; Body Composition; Body Weight; Carbon Dioxide; Carbon Isotopes; Dietary Carbohydrates; Dietary Fats; Fatty Liver; Glucose; Lipid Metabolism; Lipoproteins, LDL; Liver; Male; Methionine; Nitrogen; Protein Deficiency; Rats; Sucrose; Threonine; Time Factors

1973
Effect of amino acid supplement on liver lipid content and lipid metabolism of rats fed a nonprotein diet.
    Journal of nutritional science and vitaminology, 1974, Volume: 20, Issue:3

    Topics: Amino Acids, Essential; Animal Nutritional Physiological Phenomena; Animals; Biological Transport; Body Weight; Drug Synergism; Fatty Acids; Fatty Liver; Female; Lipid Metabolism; Lipoproteins; Lipoproteins, LDL; Liver; Male; Methionine; Phospholipids; Polyethylene Glycols; Protein Deficiency; Rats; Sex Factors; Threonine

1974
Involvement of biotin in the fatty liver and kidney syndrome of broilers.
    British poultry science, 1974, Volume: 15, Issue:5

    Topics: Animal Feed; Animals; Biotin; Diet; Fatty Liver; Housing, Animal; Kidney Diseases; Lysine; Methionine; Poultry Diseases; Syndrome; Triticum; Tryptophan; Vitamins

1974
Effect of diet on fatty liver-hemorrhagic syndrome incidence in laying chickens.
    Poultry science, 1972, Volume: 51, Issue:6

    Topics: Animals; Body Weight; Chickens; Choline; Cobalt; Diet; Fatty Liver; Female; Hemorrhage; Inositol; Lipids; Liver; Methionine; Poultry Diseases; Selenium; Syndrome; Vitamin B 12; Vitamin E

1972
Effect of various carbohydrates in a repletion diet after protein depletion on liver lipid content of rats.
    The Journal of nutrition, 1973, Volume: 103, Issue:2

    Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Caseins; Diet Therapy; Dietary Carbohydrates; Dietary Proteins; Fatty Liver; Fructose; Glucose; Lipid Metabolism; Liver; Male; Methionine; Organ Size; Polysaccharides; Protein Deficiency; Rats; Starch; Sucrose

1973
Reply to Silen's letter. "Pancreatectomy and liver damage" (January 1973).
    Archives of surgery (Chicago, Ill. : 1960), 1973, Volume: 106, Issue:2

    Topics: Animals; Dogs; Fatty Liver; Gastric Juice; Methionine; Pancreatectomy; Pancreatin

1973
Involvement of diet in fatty liver and kidney syndrome in broiler chickens.
    The Veterinary record, 1973, Feb-03, Volume: 92, Issue:5

    Topics: Animal Feed; Animals; Chickens; Choline; Diet; Edible Grain; Fatty Liver; Kidney; Kidney Diseases; Lipid Metabolism; Liver; Methionine; Poultry Diseases; Selenium; Syndrome; Vitamin B 12

1973
Response of adult rats to deficiencies of different essential amino acids.
    The British journal of nutrition, 1974, Volume: 31, Issue:1

    Topics: Amino Acids; Animals; Body Weight; Brain; Deficiency Diseases; Diet; Fatty Liver; Female; Hematocrit; Hemoglobins; Kidney; Lactalbumin; Liver; Lysine; Methionine; Nitrogen; Organ Size; Proteins; Rats; Threonine

1974
[Clinical treatment of acute and chronic liver diseases].
    Zeitschrift fur Allgemeinmedizin, 1972, Feb-10, Volume: 48, Issue:4

    Topics: Acute Disease; Choline; Chronic Disease; Fatty Liver; Hepatitis; Humans; Liver Diseases; Male; Methionine; Middle Aged

1972
Pre-erythrocytic rodent malaria, Plasmodium berghei--prevention of development in the ethionine fatty liver.
    The American journal of tropical medicine and hygiene, 1972, Volume: 21, Issue:3

    Topics: Adenosine; Animals; Erythrocytes; Ethionine; Fatty Liver; Female; Injections, Intraperitoneal; Liver; Malaria; Methionine; Methods; Plasmodium; Rats

1972
[Various effects of SAM dependent transmethylations in hepatology].
    Minerva medica, 1972, May-09, Volume: 63, Issue:35

    Topics: Adenosine; Biopsy; Chronic Disease; Fatty Liver; Hepatitis; Humans; Injections, Intraperitoneal; Lipid Metabolism; Liver Cirrhosis; Liver Diseases; Liver Glycogen; Methionine; Methylation; S-Adenosylmethionine

1972
Pancreatectomy and liver damage: effects on humoral gastric secretion in dogs.
    Archives of surgery (Chicago, Ill. : 1960), 1972, Volume: 105, Issue:3

    Topics: Animals; Dogs; Fatty Liver; Female; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Methionine; Pancreatectomy; Pancreatin; Stimulation, Chemical; Time Factors

1972
Influence of insulin, hydrocortisone and thyroxine on fatty liver of rats fed a low casein diet supplemented with methionine.
    The Journal of nutrition, 1971, Volume: 101, Issue:10

    Topics: Adrenal Glands; Adrenalectomy; Animal Nutritional Physiological Phenomena; Animals; Blood Proteins; Body Weight; Caseins; Depression, Chemical; Diabetes Mellitus, Experimental; Dietary Proteins; Fatty Liver; Female; Glucocorticoids; Hydrocortisone; Insulin; Insulin Antibodies; Iodine; Lipid Metabolism; Liver; Methionine; Pancreas; Protein Binding; Protein Deficiency; Rats; Stimulation, Chemical; Thyroid Gland; Thyroidectomy; Thyroxine

1971
Liver steatosis of force-fed geese as influenced by the protein level of the diet.
    Acta veterinaria Academiae Scientiarum Hungaricae, 1971, Volume: 21, Issue:2

    Topics: Animals; Dietary Proteins; Fatty Liver; Female; Geese; Liver; Male; Meat; Methionine; Organ Size

1971
Kipid metabolism in the rats with fatty liver caused by low protein diet and effects of the oral administration of L-methionine, L-cysteine, pantethine and calcium pantothenate upon it.
    Japanese journal of pharmacology, 1969, Volume: 19, Issue:1

    Topics: Animals; Body Weight; Calcium; Cholesterol; Chromatography, Gas; Coenzyme A; Cysteine; Dietary Fats; Fatty Acids; Fatty Liver; Lipid Metabolism; Lipids; Liver; Male; Methionine; Organ Size; Pantothenic Acid; Phospholipids; Rats; Time Factors; Triglycerides

1969
Early changes in livers of rats fed choline-deficient diets at four levels of protein.
    The American journal of pathology, 1969, Volume: 57, Issue:2

    Topics: Alkaline Phosphatase; Animals; Blood Proteins; Body Weight; Choline; Cystine; Diet; Dietary Proteins; DNA; Endoplasmic Reticulum; Fatty Liver; Hypertrophy; L-Lactate Dehydrogenase; Lipids; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Microscopy, Electron; Mitochondria, Liver; Organ Size; Rats; RNA; Transaminases

1969
Pathogenesis of methionine-induced toxicity.
    Metabolism: clinical and experimental, 1970, Volume: 19, Issue:5

    Topics: Adenosine Triphosphate; Amino Acids; Animals; Fatty Liver; Female; Guinea Pigs; Hypoglycemia; Hypothermia; Kidney; Liver; Liver Glycogen; Male; Methionine; Nucleosides; Rats; Spasm; Stereoisomerism

1970
[Liver function tests with methionine-Se 75 in diabetics].
    Medicina interna, 1970, Volume: 22, Issue:9

    Topics: Diabetes Complications; Diabetes Mellitus; Fatty Liver; Hepatomegaly; Humans; Liver; Liver Function Tests; Methionine; Selenium

1970
Modification of the hepatotoxic action of neptunium-237 in the rat.
    Toxicology and applied pharmacology, 1971, Volume: 18, Issue:3

    Topics: Adenine; Adenosine Triphosphate; Adrenalectomy; Alanine Transaminase; Animals; Antioxidants; Cresols; Estradiol; Fatty Liver; Female; Glucose; Hypophysectomy; Isocitrate Dehydrogenase; Liver; Male; Methionine; Neptunium; Nicotinic Acids; Rats; Testosterone

1971
On the ethionine-induced inhibition of protein synthesis in male and female rats--lack of effect on intestinal mucosa.
    Biochimica et biophysica acta, 1968, Jun-24, Volume: 158, Issue:3

    Topics: Animals; Blood Proteins; Carbon Isotopes; Depression, Chemical; Dietary Fats; Ethionine; Fatty Liver; Female; Intestinal Mucosa; Jejunum; Leucine; Lipoproteins; Liver; Male; Methionine; Protein Biosynthesis; Rats; Sex; Triglycerides; Tritium; Ultracentrifugation; Zea mays

1968
Methionine-responsive liver damage in young pigs fed a diet low in protien and vitamin E.
    The Journal of nutrition, 1968, Volume: 95, Issue:4

    Topics: Animals; Aspartate Aminotransferases; Blood Proteins; Body Weight; Choline; Diet; Fatty Liver; Female; Lipid Metabolism; Liver; Liver Diseases; Male; Methionine; Necrosis; Protein Deficiency; Selenium; Swine; Time Factors; Vitamin E; Vitamin E Deficiency

1968
The induction of liver cirrhosis in rats by purified amino acid diets.
    Cancer research, 1969, Volume: 29, Issue:1

    Topics: Amino Acids; Animals; Body Weight; Cholesterol; Choline Deficiency; Deficiency Diseases; Diet; Dietary Proteins; DNA; Fatty Liver; Lipids; Liver; Liver Cirrhosis; Male; Methionine; Rats; Thymidine; Triglycerides; Tritium; Vitamin B 12 Deficiency

1969
[On methylation processes in metabolism].
    Die Medizinische Welt, 1969, Feb-22, Volume: 8

    Topics: Biochemical Phenomena; Biochemistry; Choline; Dietary Fats; Epinephrine; Fatty Liver; Humans; Mescaline; Metabolism; Methionine; Methylation; Norepinephrine; Phenethylamines; Phosphatidylcholines; Schizophrenia

1969
Studies on phospholipid metabolism in choline deficient fatty liver.
    Journal of biochemistry, 1969, Volume: 65, Issue:1

    Topics: Animals; Carbon Isotopes; Choline; Choline Deficiency; Chromatography; Fatty Acids; Fatty Liver; Female; Male; Methionine; Methylation; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorus Isotopes; Proteins; Rats

1969
Effect of dl-ethionine and naturally occurring amino acids on adrenal necrosis induced by 7,12-dimethyl-benz [alpha]anthracene and its 7-hydroxymethyl derivative in female Sprague-Dawley rats.
    British journal of experimental pathology, 1969, Volume: 50, Issue:1

    Topics: Adrenal Gland Diseases; Amino Acids; Animals; Arginine; Benz(a)Anthracenes; Ethionine; Fatty Liver; Female; Glycine; Liver; Methionine; Necrosis; Protein Biosynthesis; Rats

1969
Influence of ethionine on choline-deficiency fatty liver.
    The Journal of nutrition, 1969, Volume: 97, Issue:3

    Topics: Alcohol Oxidoreductases; Animals; Body Weight; Carbon Isotopes; Choline Deficiency; Depression, Chemical; Ethionine; Fasting; Fatty Liver; Female; Lipid Metabolism; Liver; Male; Methionine; Organ Size; Protein Biosynthesis; Proteins; Rats; Time Factors

1969
Metabolism of phosphorylcholine and lecithin in normal and choline-deficient rats.
    Biochimica et biophysica acta, 1969, Mar-04, Volume: 176, Issue:2

    Topics: Animals; Carbon Isotopes; Choline; Choline Deficiency; Fatty Liver; Lipid Metabolism; Liver; Male; Methionine; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorus Isotopes; Rats

1969
[Considerations on the therapy of hepatic steatosis].
    Minerva medica, 1969, Aug-29, Volume: 60, Issue:69

    Topics: Adult; Aged; Alcoholism; Choline; Colitis, Ulcerative; Diabetes Complications; Fatty Liver; Gout; Hepatitis A; Humans; Inositol; Methionine; Middle Aged; Vitamin B Complex

1969
Alterations in phospholipid metabolism induced by ethanol administration.
    Biochimica et biophysica acta, 1965, Jun-01, Volume: 98, Issue:3

    Topics: Alkylation; Animals; Choline; Chromatography, Thin Layer; Ethanol; Fatty Liver; Formates; In Vitro Techniques; Liver; Methionine; Phosphatidylcholines; Phospholipids; Rats; Serine

1965
Choline metabolism in normal and choline-deficient rats of different ages.
    Archives of biochemistry and biophysics, 1965, Volume: 112, Issue:1

    Topics: Aging; Animals; Body Weight; Choline; Choline Deficiency; Fatty Liver; Hemorrhage; Kidney; Liver; Methionine; Rats; Vitamin B Deficiency

1965
Environmental temperature and choline requirements in rats. II. Choline and methionine requirements for lipotropic activity.
    Journal of lipid research, 1966, Volume: 7, Issue:1

    Topics: Animals; Choline; Choline Deficiency; Deficiency Diseases; Fatty Liver; Lipid Metabolism; Liver; Methionine; Rats; Temperature

1966
Study of agents for the prevention of the fatty liver produced by prolonged alcohol intake.
    Gastroenterology, 1966, Volume: 50, Issue:3

    Topics: Alcohol Deterrents; Alcoholism; Animals; Antioxidants; Choline; Diet; Fatty Liver; Glycerides; Humans; Methionine; Rats

1966