methionine has been researched along with Hyperhomocysteinemia in 387 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.26) | 18.7374 |
| 1990's | 24 (6.20) | 18.2507 |
| 2000's | 213 (55.04) | 29.6817 |
| 2010's | 122 (31.52) | 24.3611 |
| 2020's | 27 (6.98) | 2.80 |
| Authors | Studies |
|---|---|
| Guieu, R; Mottola, G; Ruf, J | 1 |
| Caccamo, D; Cordaro, M; Crupi, R; Cuzzocrea, S; D'Amico, R; Di Paola, R; Fusco, R; Genovese, T; Gugliandolo, E; Impellizzeri, D; Mandalari, G; Peritore, AF; Siracusa, R | 1 |
| Aouichat, S; Benazzoug, Y; Chalour, N; Chaouad, B; Cherifi, MEH; Ghoul, A; Houali, K; Khiari, Z; Moulahoum, A; Zerrouk, F | 1 |
| Abdul Ghani, SAB; Arul, K; Bee, GGB; Cheah, CC; Chow, PKH; Cook, SA; Lim, TR; Pei, HJ; Sandireddy, R; Shekeran, SG; Singh, BK; Singh, MK; Sinha, RA; Suzuki, A; Tikno, K; Tripathi, M; Wang, J; Widjaja, A; Wong, KA; Xiao, RP; Yen, PM; Zhang, X; Zhou, J | 1 |
| Balwani, M; Fanelli, MJ; Gouya, L; Longo, N; Petrides, PE; Phillips, J; Plutzky, J; Rhyee, S; Sardh, E; Sweetser, MT; Ventura, P | 1 |
| Deng, Y; Kong, J | 1 |
| Amer, ME; El-Missiry, MA; ElKomy, MA; Mostafa, MD; Othman, AI | 1 |
| Ding, P; Li, H; Sun, J; Weng, L; Xiang, W; Yang, Y; Ye, Z; Zeng, C | 1 |
| Adamkov, M; Hnilicova, P; Kalenska, D; Kovalska, L; Kovalska, M; Lehotsky, J | 1 |
| Gu, J; Lei, C; Zhang, M | 1 |
| Benyo, Z; Csik, B; Csiszar, A; Gulej, R; Mukli, P; Negri, S; Tarantini, S; Ungvari, A; Ungvari, Z; Yabluchanskiy, A | 1 |
| Choi, ET; Cueto, R; Fang, P; Fu, H; Gao, C; Liu, L; Shao, Y; Shen, W; Wang, H; Wu, Q; Yang, WY; Yang, X | 1 |
| Deng, M; Guo, W; Jiang, Y; Ma, P; Ma, S; Mao, C; Nie, L; Sun, J; Sun, L; Wang, N; Xiong, J; Yang, A; Zhang, H | 1 |
| Adamkov, M; Hnilicova, P; Kalenska, D; Kovalska, M; Lehotsky, J; Tothova, B | 1 |
| Aburashed, ZO; Alzoubi, KH; Mayyas, F | 1 |
| Arutjunyan, AV; Kerkeshko, GO; Mikhel, AV; Milyutina, YP; Shcherbitskaia, AD; Zalozniaia, IV | 1 |
| Bergamini, C; Capelli, I; Cappuccilli, M; Cianciolo, G; Conte, D; Donati, G; Giacomelli, FA; La Manna, G; Natali, T | 1 |
| Fiskum, G; Goodfellow, M; Li, F; Miller, C; Puche, A; Ramsue, L; Tchantchou, F | 1 |
| Arutjunyan, AV; Kerkeshko, GO; Milyutina, YP; Shcherbitskaia, AD; Tumanova, NL; Vasilev, DS; Zalozniaia, IV | 1 |
| George, AK; Homme, RP; Jovanovic, M; Singh, M; Stanisic, D; Tyagi, N; Tyagi, SC | 1 |
| Adamkov, M; Hnilicova, P; Kalenska, D; Kovalska, M; Lehotsky, J; Tomascova, A | 1 |
| Bhatia, P; Singh, N | 1 |
| Andriamihaja, M; Blachier, F; Blais, A | 1 |
| Cynober, L; Deutz, NEP; Engelen, MPKJ; Ligthart-Melis, GC; Simbo, SY; Ten Have, GAM; Thaden, JJ | 1 |
| Aarsand, AK; Aguilera, P; Brunet, M; Deulofeu, R; García-Villoria, J; Gómez-Gómez, À; Pozo, OJ; Sandberg, S; To-Figueras, J; Wijngaard, R | 1 |
| Burkhanova, G; Chernova, K; Enikeev, D; Gerasimova, E; Giniatullin, R; Khaertdinov, N; Sitdikova, G; Zakharov, A | 1 |
| Adamkov, M; Baranovicova, E; Kalenska, D; Kovalska, L; Kovalska, M; Lehotsky, J; Tomascova, A | 1 |
| Arutjunyan, AV; Mikhel, AV; Milyutina, YP; Shcherbitskaia, AD; Tumanova, NL; Vasilev, DS; Zalozniaia, IV | 1 |
| Ai, Y; Li, J; Liu, L; Peng, C; Sun, Z; Xiao, X | 1 |
| Arutyunyan, AV; Kerkeshko, GO; Korenevskii, AV; Milyutina, YP; Zaloznyaya, IV | 1 |
| Deng, M; Ding, N; Gao, Y; Jia, Y; Jiang, Y; Mao, C; Sun, Y; Wang, Y; Yang, A; Yang, S; Yang, X; Zhang, H | 1 |
| Padovani, D | 1 |
| Belskikh, ES; Bulatetskiy, SV; Medvedev, DV; Ryabkov, AN; Uryasev, OM; Zvyagina, VI | 1 |
| Chan, SH; Cheng, YH; Chu, PM; Hsieh, PL; Hung, CH; Lin, HC; Shih, JY; Tsai, KL | 1 |
| Ingenbleek, Y | 1 |
| Djonic, D; Djuric, D; Djuric, M; Hrncic, D; Milovanovic, P; Mutavdzic, D; Radotic, K; Rasic-Markovic, A; Stankovic, M; Stanojlovic, O | 1 |
| Azad, MAK; Huang, P; Liu, G; Ren, W; Teklebrh, T; Yan, W; Yin, Y; Zhou, X | 1 |
| Tan, X; Wang, WZ; Wang, YK; Xu, H; Zhao, YH; Zhong, MF | 1 |
| Djuric, D; Jakovljevic, V; Jancic, S; Jeremic, J; Jeremic, N; Matic, S; Milosavljevic, I; Nikolic Turnic, T; Obrenovic, R; Rakocevic, M; Srejovic, I; Zivkovic, V | 1 |
| Chang, D; Hasegawa, H; Ichida, K; Inaba, N; Li, L; Liu, J; Yoshioka, W | 1 |
| Alzoubi, KH; Khabour, OF; Mhaidat, NM; Obaid, EA | 1 |
| Ostrakhovitch, EA; Tabibzadeh, S | 1 |
| Geng, J; Li, X; Wang, L; Zhang, Y; Zhou, X | 1 |
| Behera, J; Tyagi, N; Tyagi, SC | 1 |
| Barroso, M; Castro, R; Esse, R; Tavares de Almeida, I | 1 |
| Cannegieter, SC; Hensen, ADO; Lijfering, WM; Rosendaal, FR; van Hylckama Vlieg, A | 1 |
| Goyal, A; Gupta, JK; Narayan Yadav, H; Qureshi, SS | 1 |
| Benazzoug, Y; Chaouad, B; Cherifi, MEH; Exbrayat, JM; Ghoul, A; Moudilou, EN; Moulahoum, A; Othmani-Mecif, K; Zerrouk, F | 1 |
| Gao, W; Guo, C; Meng, B; Pu, L; Wei, J; Wu, J; Yang, J | 1 |
| Eleftheriadou, I; Grigoropoulou, P; Katsilambros, N; Kokkinos, A; Moyssakis, I; Perrea, D; Tentolouris, N; Toutouzas, K | 1 |
| Devlin, AM; Glier, MB; Green, TJ | 1 |
| Blanco-Vaca, F; Escolà-Gil, JC; Jauhiainen, M; Julve, J; Martín-Campos, JM; Osada, J; Quesada, H; Rentería-Obregón, IM; Rodríguez-Millán, E; Sánchez-Quesada, JL | 1 |
| Joseph, J; Loscalzo, J | 1 |
| Brown, K; Givvimani, S; Kalani, A; Kamat, PK; Metreveli, N; Tyagi, N; Tyagi, SC | 1 |
| Belló-Klein, A; Candido, GO; D'Almeida, V; Irigoyen, MC; Mendes, RH; Moraes-Silva, IC; Mostarda, C; Rigatto, K | 1 |
| Bartalini, S; Coppo, L; Di Giuseppe, D; Di Simplicio, P; Frosali, S; Margaritis, A; Priora, R; Summa, D; Ulivelli, M | 1 |
| de Lourdes Barbosa-Cortés, M; Del Prado-Manríquez, M; Maldonado-Hernández, J; Montalvo-Velarde, I; Prina-Ojeda, LV; Repetto-Madrid, M | 1 |
| Jakubowski, H; Luczak, M; Marczak, L; Suszyńska-Zajczyk, J; Utyro, O; Wróblewski, J | 1 |
| Akahoshi, N; Hishiki, T; Ishii, I; Ishizaki, Y; Kamata, S; Kasahara, T; Kubota, M; Matsuura, T; Nagahata, Y; Suematsu, M; Yamada, H; Yamazaki, C; Yoshida, Y | 1 |
| Bahous, RH; Bedell, BJ; Caudill, MA; Deng, L; Grand'maison, M; Jadavji, NM; Malysheva, O; Rozen, R | 1 |
| Akkaya, H; Dinc, SE; Kilic, E; Yilmaz, B | 1 |
| Jakubowski, H; Suszyńska-Zajczyk, J; Utyro, O | 1 |
| Sabour, S | 1 |
| Feng, L; Han, C; Li, M; Liu, J; Mao, J; Pang, X; Wang, S; Wu, D; Zhang, X; Zhao, J | 1 |
| Djuric, D; Hrnčić, D; Jakovljević, V; Macut, D; Obrenović, R; Petronijević, N; Puškaš, N; Rašić-Marković, A; Stanojlović, O; Stojković, T; Sušić, V; Velimirović, M | 1 |
| D'Almeida, V; de Rezende, MM | 1 |
| Bai, L; Chen, Y; Fan, J; Li, Y; Liu, E; Liu, R; Wang, Y; Zhao, S | 1 |
| Arning, E; Blokhin, IO; Bottiglieri, T; Dayal, S; Erger, RA; Faraci, FM; Jensen, M; Lentz, SR; Stevens, JW | 1 |
| Chengfeng, S; Lei, W; Lingjia, Q; Rui, Z; Wei, L; Xinxing, W | 1 |
| Jakubowski, H; Suszyńska-Zajczyk, J | 1 |
| Cediel, R; Garrido, F; Martínez-Álvarez, C; Martínez-Vega, R; Pajares, MA; Partearroyo, T; Varela-Moreiras, G; Varela-Nieto, I; Zeisel, SH | 1 |
| Heil, SG; Mandaviya, PR; Stolk, L | 1 |
| Arutiunian, AV; Miliutina, IuP; Pustygina, AV; Shcherbitskaia, AD; Zalozniaia, IV; Zorina, II | 1 |
| Comparotto, H; Deminice, R; Jordao, AA | 1 |
| Choi, HS; Choi, YJ; Kim, SK; Kwak, HC; Lee, BH; Sim, WC; Yin, HQ | 1 |
| Baggott, JE; Tamura, T | 1 |
| Ables, GP; Augie, I; Cooke, D; Hampton, TG; Orentreich, DS; Ouattara, A; Perodin, F | 1 |
| Akgullu, C; Boyacioglu, M; Dogan, E; Eryilmaz, U; Guleş, O; Güngör, H; Hekim, T; Huyut, MA; Zencir, C | 1 |
| Bamba, M; Hirota, T; Miyajima, A; Muto, T | 1 |
| Borderie, D; Bos, C; Huneau, JF; Magné, J; Mariotti, F; Mathé, V | 1 |
| Reimann, M; Weiss, N; Ziemssen, T | 1 |
| Reimann, M; Rüdiger, H; Weiss, N; Ziemssen, T | 1 |
| Chan, SH; Chu, PM; Hung, CH; Tsai, KL | 1 |
| Han, F; Huang, Z; Liu, Y; Lu, J; Sugiyama, K; Sun, L; Wang, Q | 1 |
| Cao, YJ; Cheng, J; Du, HP; Hu, LF; Li, JJ; Li, Q; Liu, CF; Wang, F; Wang, YL; Xu, XS; You, SJ | 1 |
| Cao, J; Jia, YX; Jiang, YD; Li, GZ; Ma, SC; Sun, Y; Wang, N; Xu, H; Yang, AN; Yang, XL; Zhang, H; Zhang, HP; Zhang, Y; Zhu, G | 1 |
| Ai, D; He, J; Jiang, C; Liu, W; Liu, Y; Peng, L; Wang, C; Yao, L; Zhang, X; Zhu, Y | 1 |
| Chen, Z; Jia, F; Lu, G; Sun, J; Wu, C | 1 |
| Bartalini, S; Cerase, A; Coppo, L; Di Giuseppe, D; Di Simplicio, P; Frosali, S; Margaritis, A; Martini, G; Priora, R; Summa, D; Ulivelli, M | 1 |
| Chung, YC; Feierman, E; Kruyer, A; Norris, EH; Richards, A; Strickland, S; Yao, Y | 1 |
| Benazzoug, Y; Janel, N; Latour, A; Middendorp, S; Otman, A; Yefsah-Idres, A | 1 |
| Hashimoto, T; Kanematsu, Y; Kitazato, KT; Korai, M; Matsushita, N; Miyamoto, T; Nagahiro, S; Satomi, J; Shimada, K; Tada, Y | 1 |
| Bertolo, RF; Brunton, JA; McBreairty, LE; Randell, EW; Robinson, JL | 1 |
| Arun Reddy, R; Dinesh Kumar, B; Diwan, PV; Hemanth Kumar, B; Mahesh Kumar, J | 1 |
| Mohajeri, MH; Troesch, B; Weber, P | 1 |
| Chen, D; Cong, G; Hou, J; Huang, H; Jia, S; Jin, P; Wang, K; Yan, N; Yan, R; Zhang, N | 1 |
| Prakash, A; Singh, M | 1 |
| Balakumar, P; Singh, AP; Singh, M | 1 |
| Karasu, E; Sadan, G; Tasatargil, A | 1 |
| Arning, E; Bottiglieri, T; Cooke, JP; Dayal, S; Faraci, FM; Kimoto, M; Lentz, SR; Murry, DJ; Rodionov, RN | 1 |
| Chandra, R; Rai, SK; Sharma, M; Tiwari, M; Tiwari, RK | 1 |
| Fukada, S; Morita, T; Sugiyama, K | 1 |
| Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K | 2 |
| Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE | 1 |
| Delabar, JM; Hamelet, J; Janel, N; Matulewicz, E; Noll, C; Paul, JL | 1 |
| Ansari, MN; Bhandari, U; Nigam, GK | 1 |
| Shea, TB; Tchantchou, F | 1 |
| Ansari, MN; Bhandari, U | 1 |
| Ansari, MN; Bhandari, U; Kapoor, P | 1 |
| Bonaventura, D; de Oliveira, AM; Tirapelli, CR | 1 |
| Antoniades, C; Bouras, G; Latsios, G; Marinou, K; Siasos, G; Stefanadi, E; Stefanadis, C; Tousoulis, D; Toutouzas, K; Vasiliadou, C | 1 |
| Chen, FP; Cheng, CH; Chou, MC; Huang, YC; Tsai, TP | 1 |
| Cho, CW; Park, CM; Rosenfeld, ME; Song, YS | 1 |
| Doğru-Abbasoğlu, S; Giriş, M; Olgaç, V; Unlüçerçi, Y; Uysal, M; Yalçinkaya, S | 1 |
| Garcia, P; Herrmann, M; Herrmann, W; Hübner, U; Ross, S; Schorr, H; Taban-Shomal, O; Tami, A; Umanskaya, N; Wagner, A; Wildemann, B; Wolny, M | 1 |
| Matsumoto, Y; Morita, T; Ohuchi, S; Sugiyama, K | 2 |
| Chen, FY; Chen, L; Gao, W; Guo, YH; Wang, GS | 1 |
| Arning, E; Banerjee, R; Bottiglieri, T; Hernandez, C; Li, S; Lin, JD; Liu, C; Vitvitsky, V | 1 |
| Cabrera, RM; Finnell, RH; Gupta, S; Jakubowski, H; Kraus, JP; Kruger, WD; Perla-Kaján, J; Shih, DM; Wang, H | 1 |
| Gurzhiĭ, AA; Papaian, LP; Saltykova, NB; Shmeleva, VM | 1 |
| Deussen, A; Henle, T; Herrmann, M; Pexa, A; Taban-Shomal, O | 1 |
| Cho, C; Cho, M; Rosenfeld, ME; Song, Y | 1 |
| Kawakami, Y; Morita, T; Ohuchi, S; Sugiyama, K | 1 |
| Cao, Y; Chai, JG; Chen, YC; Liu, XD; Liu, XQ; Ma, C; Shao, JP; Zhao, J; Zhou, J | 1 |
| Kida, Y; Marumo, K; Saito, M; Shinohara, A; Soshi, S; Ushiku, C | 1 |
| Anand-Srivastava, MB; Balakumar, P; Reddy, K; Singh, H | 1 |
| Gültepe, M; Ipçioğlu, OM; Kiralp, MZ; Ozçakar, L; Ozcan, O | 1 |
| Du, J; Jin, H; Liu, D; Tang, C; Tang, X; Wei, H; Zhang, R | 1 |
| Almeida, D; Broekman, MJ; Deora, AB; Greenberg, CB; Hajjar, KA; Jacovina, AT; Ling, Q; Marcus, AJ; Smith, JD | 1 |
| Bala kumar, P; Rohilla, A; Singh, G; Singh, M | 1 |
| Dayal, S; DiBello, PM; Jacobsen, DW; Kaveti, S; Kinter, M; Lentz, SR; Zhang, D | 1 |
| Bottiglieri, T; Devlin, AM; Green, TJ; Innis, SM; Singh, R | 1 |
| Arning, E; Baumbach, GL; Bottiglieri, T; Cooke, JP; Dayoub, H; Faraci, FM; Kimoto, M; Lentz, SR; Lynch, CM; Murry, DJ; Rodionov, RN; Stevens, JW; Wilson, KM | 1 |
| Balakrishnan, V; Girish, BN; Rajesh, G; Rao, NA; Reshmi, S; Vaidyanathan, K | 1 |
| Antoniades, C; Bouras, G; Chatzis, G; Marinou, K; Miliou, A; Papageorgiou, N; Stefanadis, C; Tentolouris, C; Tousoulis, D; Tsioufis, C | 1 |
| Baydas, G; Demir, N; Etem, E; Gouwy, NT; Koz, ST; Nedzvetsky, VS | 1 |
| Doupis, J; Eleftheriadou, I; Gonis, A; Katsilambros, N; Kokkinos, A; Pavlatos, S; Perrea, D; Tentolouris, N | 1 |
| Kaur, T; Pal Singh, A; Singh Bedi, PM; Singh, N; SinghDahiya, R | 1 |
| Chousos, I; Katsilambros, N; Kyriaki, D; Liatis, S; Makrilakis, K; Perrea, D | 1 |
| Praticò, D; Zhuo, JM | 1 |
| Aléssio, AC; Annichino-Bizzacchi, JM; Debbas, V; Haddad, R; Oliveira, LC; Santos, CX | 1 |
| Li, L; Li, Q; Sun, J; Tan, HM; Wu, WK; Yan, TT; Zhang, Q; Zhang, XH | 1 |
| Bosma, JP; Klip, H; Nooij, LS; van de Leur, JJ; van Eyck, J | 1 |
| Afrasibi, AR; Akbari, A; Dehbozorgian, J; Gafari, H; Gerdabi, J; Karimi, M | 1 |
| Cao, J; Gao, SY; Li, SD; Liu, WH; Zhang, KQ; Zhao, YS; Zou, CG | 1 |
| Huang, SY; Liu, Y; Liu, YF; Lu, XT; Xing, YF; Yan, FF; Yang, RX; Zhao, YX | 1 |
| Au-Yeung, KK; House, J; Hwang, SY; O, K; Siow, YL | 1 |
| Steed, MM; Tyagi, SC | 1 |
| Li, CY; Li, JX; Tang, CS; Yang, Y; Yu, F | 1 |
| Benard, L; Dairou, J; Delcayre, C; Janel, N; Noll, C; Paul, JL; Petit, E; Planque, C; Raaf, L; Rodrigues-Lima, F; Samuel, JL; Secardin, L | 1 |
| Duan, JH; Hong, N; Hou, DD; Wang, HX; Wang, W; Zhao, Q; Zhen, HX; Zhen, PP | 1 |
| Dong, JF; Tian, Y; Wei, HJ; Xu, Y; Zhang, JN | 1 |
| Bhandari, U; Khanna, N; Kumar, V; Pathan, RA | 1 |
| Liu, WH; Liu, WJ; Ma, LQ; Zhang, KQ; Zhou, W; Zou, CG | 1 |
| Antoniades, C; Bouras, G; Hatzis, G; Marinou, K; Miliou, A; Papageorgiou, N; Stefanadi, E; Stefanadis, C; Tousoulis, D; Tsioufis, C | 1 |
| Herrmann, M; Herrmann, W; Obeid, R; Schlundt, J; Umanskaya, N | 1 |
| Deng, Y; Duan, Y; Guo, J; Kuang, D; Wan, J; Wang, G; Xiao, G; Zhu, Y | 1 |
| Cavalca, V; Coppola, A; D'Angelo, A; Di Minno, G; Di Minno, MN; Palmieri, V; Pezzullo, S; Sampietro, F; Tremoli, E | 1 |
| Dilger, RN; Garrow, TA; Gupta, S; Kruger, WD; Li, L; Strakova, J; Tryon, K | 1 |
| Ren, XL; Yang, B; Yu, Q; Zhang, J | 1 |
| Brosnan, JT; Brosnan, ME; Lamarre, SG; Molloy, AM; Reinke, SN; Sykes, BD | 1 |
| Baydas, G; Demir, N; Koz, S; Koz, ST; Nedzvetsky, VS | 1 |
| Liu, Y; Liu, YQ; Morita, T; Sugiyama, K | 1 |
| Akahoshi, N; Hagiya, Y; Hishiki, T; Ishii, I; Ishizaki, Y; Izumi, T; Kamata, S; Kasahara, T; Kumagai, Y; Matsuura, T; Mori, M; Nagahata, Y; Suematsu, M; Takano, N; Yamada, H | 1 |
| Sharma, B; Singh, N | 1 |
| Assis, PA; Baggio, MS; Bassi, SC; Benício, MT; Falcão, RP; Figueiredo-Pontes, LL; Garcia, AB; Jácomo, RH; Lange, AP; Lima, AS; Oliveira, LO; Rego, EM; Santana-Lemos, BA | 1 |
| Avvisati, G | 1 |
| Basili, S; Cerasa, L; Ciabattoni, G; Davì, G; Dragani, A; Falco, A; Lattanzio, S; Patrono, C; Rolandi, G; Santilli, F | 1 |
| Liu, Y; Liu, YQ; Mori, M; Morita, T; Sugiyama, K | 1 |
| Belous, AS; Danilenko, LM; Denisyuk, TA; Gudyrev, OS; Gureev, VV; Konovalova, EA; Korokin, MV; Korokina, LV; Novikov, OO; Pokrovskiy, MV; Ragulina, VA | 1 |
| Alonso-Aperte, E; Partearroyo, T; Pérez-Miguelsanz, J; Úbeda, N; Valencia-Benítez, M; Varela-Moreiras, G | 1 |
| Janel, N; Lameth, J; Noll, C; Paul, JL | 1 |
| D'Almeida, V; Poloni, S; Schwartz, IV; Schweigert Perry, ID | 1 |
| Gong, H; Jiang, Y; Shi, Y; Sun, T; Sun, W; Wang, J; Wei, J; Yang, B; Zhang, H | 1 |
| Hayakawa, T; Isa, Y; Nakagawa, T; Yamamoto, K | 2 |
| Bertolo, RF; McBreairty, LE | 1 |
| Asmadi, AY; Azizi, A; Faizah, O; Kamisah, Y; Norsidah, KZ | 1 |
| Greenstein, A; Powell, DK; Smith, CD; Sudduth, TL; Wilcock, DM | 1 |
| Guo, Q; Lu, J; Pan, C | 1 |
| Hoffer, LJ | 2 |
| Arning, E; Bottiglieri, T; Erger, RA; Fernández, JA; Griffin, JH; Haynes, WG; Heistad, DD; Lentz, SR; Malinow, MR; Piegors, DJ | 1 |
| Lau, YT; Yen, CH | 1 |
| Hagar, HH | 1 |
| Hirosawa, K; Hishida, A; Ikegaya, N; Katoh, S; Kimura, M; Kumagai, H | 1 |
| Alpert, NM; Cooke, JP; Creager, MA; Fischman, AJ; Forgione, MA; Gewirtz, H; Loscalzo, J; Stuehlinger, M; Tawakol, A | 1 |
| de Meer, K; Finglas, P; Smulders, Y; Stam, F; Stehouwer, CD; van den Akker, JT | 1 |
| Herrmann, W; Knapp, JP; Lemmerer, M; Rigler, B; Semmelrock, HJ; Stanger, O | 1 |
| Apeland, T; Mansoor, MA; McNulty, H; Pentieva, K; Seljeflot, I; Strandjord, RE | 1 |
| Baumbach, GL; Bottiglieri, T; Lentz, SR; Sigmund, CD | 1 |
| O'Donnell, J; Perry, DJ | 1 |
| Arning, E; Bottiglieri, T; Brown, KL; Dayal, S; Faraci, FM; Lentz, SR; Oberley, LW; Weydert, CJ | 1 |
| Akcakus, M; Halici, C; Karaküçük, I; Narin, F; Narin, N; Ustdal, M | 1 |
| Auch, D; Kaps, M; Osthaus, S; Rosengarten, B | 1 |
| Barcellona, D; Contu, P; Fenu, L; Marongiu, F; Pisu, G | 1 |
| Miller, AL | 1 |
| Haynes, WG | 1 |
| Berthelot, A; Groubatch, F; Jacqueson, A; Laurant, P; Maupoil, V; Robin, S | 1 |
| Dijck-Brouwer, DA; Fokkema, MR; Muskiet, FA; Reijngoud, DJ; van Doormaal, JJ | 1 |
| Cerula, SL; Huber, HA; Majors, AK; Powers, RW; Roberts, JM; Schmidt, BP | 1 |
| Battaglioli, T; Cattaneo, M; Mannucci, PM; Martinelli, I; Pedotti, P | 1 |
| Finkelstein, JD | 1 |
| Bosy-Westphal, A; Czech, N; Fleig, W; Hinrichsen, H; Lotterer, E; Müller, MJ; Oehler, G; Plauth, M; Ruschmeyer, M | 1 |
| Ji, C; Kaplowitz, N | 1 |
| Allen, RH; Ampola, MG; Borschel, MW; Braverman, N; Garganta, C; Harvey Mudd, S; Jayakar, P; Kronick, J; Levy, HL; McCandless, SE; Pomper, M; Stabler, SP; Tezcan, K; Wagner, C; Wiltse, H | 1 |
| Austin, RC; Falk, E; Larsen, ML; Møller, J; Ritskes-Hoitinga, M; Zhou, J | 1 |
| Favier, A; Galan, P; Guilland, JC; Hercberg, S; Potier de Courcy, G | 1 |
| Hogan, K; Laxova, R; Rosenblatt, DS; Selzer, RR | 1 |
| Fan, B; Haines, CJ; Li, EK; Tam, LS; Thomas, GN; Tomlinson, B; Yim, SF | 1 |
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| Algra, A; Banga, JD; de Valk, HW; Grobbee, DE; van de Laak, MF; van der Graaf, Y; van der Griend, R | 1 |
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| de Meer, K; Jakobs, C; Stam, F; Stehouwer, CD; Ter Wee, PM; van Guldener, C | 1 |
| Al-Shaer, MH; Browning, R; Chenard, C; Haynes, WG; Raghuveer, G; Sinkey, CA; Stumbo, P | 1 |
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| Baydas, G; Koz, ST; Ozer, M; Tuzcu, M; Yasar, A | 1 |
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| Bouzouf, M; Guerrero, JM; Martinez-Cruz, F; Molinero, P; Osuna, C | 1 |
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| Jakubowski, H | 1 |
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| Arning, E; Austin, RC; Bottiglieri, T; Lentz, SR; Leo, L; Lhoták, S; McCaw, RB; Wilson, KM | 1 |
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| Bottiglieri, T; Cross, JC; Elmore, CL; Gravel, RA; Krupenko, NI; Krupenko, SA; Leclerc, D; Matthews, RG; Rozen, R; Watson, ED; Wu, X | 1 |
| Badrinath, VS; Karunakaran, C; Narayanasamy, A; Ranganathan, P; Roy, J; Sharma, T; Sivaramakrishnan, R; Subramaniam, B | 1 |
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| Agnati, LF; Andreoli, N; Astancolle, S; Carone, C; Davalli, P; Filaferro, M; Fuxe, K; Genedani, S; Leo, G | 1 |
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| Donmez, L; Herrmann, M; Ozdem, S; Sadan, G; Samanci, S; Tasatargil, A; Yildiz, A | 1 |
| Kumar, M; Moshal, KS; Rodriguez, WE; Sen, U; Tyagi, N; Tyagi, SC | 1 |
| Hasegawa, H; Hashimoto, T; Shinohara, Y | 1 |
| Majluf-Cruz, A; Montano-Loza, A; Uscanga, L; Vargas-Vorackova, F; Zapata-Colindres, JC; Zepeda-Gómez, S | 1 |
| Chen, H; Li, J; Li, L; Liu, X; Luo, F; Wu, W | 1 |
| Au-Yeung, KK; Hwang, SY; O, K; Siow, YL; Woo, CW; Zhu, TY | 1 |
| Barsacchi, R; Barsanti, L; Battaglia, D; Kusmic, C; Palombo, C; Paolicchi, A; Parodi, O; Taddei, MC; Vesentini, N | 1 |
| Edirimanne, VE; O, K; Pierce, GN; Siow, YL; Woo, CW; Xie, JY | 1 |
| Distrutti, E; Donini, A; Fiorucci, S; Mencarelli, A; Orlandi, S; Renga, B; Santucci, L; Shah, V | 1 |
| Chen, T; Deaciuc, I; McClain, CJ; Song, Z; Zhou, Z | 1 |
| Boeger, RH; Deussen, A; Henle, T; Pexa, A; Schwedhelm, E | 1 |
| de Jonge, R; Dunkelgrun, M; Feringa, HH; Goei, D; Hoeks, SE; Lindemans, J; Poldermans, D; Schouten, O; van Domburg, RT; van Gestel, YR; Vidakovic, R; Welten, GM | 1 |
| Austin, RC; DiBello, PM; Dickhout, J; Jacobsen, DW; Lhoták, S; Majors, AK; Shi, YY; Tedesco, V; Trigatti, B; Werstuck, GH; Zhou, J | 1 |
| Abbate, R; Bolli, P; Gensini, GF; Giusti, B; Gori, AM; Magi, A; Marcucci, R; Saracini, C; Sestini, I; Sticchi, E | 1 |
| Antolini, L; Conti, E; DeFilippi, F; Facheris, M; Fenaroli, F; Ferrarese, C; Galimberti, G; Isella, V; Perlangeli, V; Piazza, F; Zini, M | 1 |
| Ning, G; Zhang, YF | 1 |
| Han, Q; Hoffman, RM; Lenz, M; Miljkovic, D; Sun, X; Tan, X; Tan, Y; Tang, L; Xu, M | 1 |
| Bellamy, MF; Bones, C; Brownlee, M; Lewis, MJ; McDowell, IF; Newcombe, RG; Ramsey, MW | 1 |
| Imaizumi, T; Matsuoka, H; Miyazaki, H; Okuda, S; Ueda, S; Usui, M | 1 |
| Cattaneo, M | 1 |
| Chambers, JC; Jean-Marie, J; Kooner, JS; McGregor, A; Obeid, OA | 1 |
| de Meer, K; Donker, AJ; Janssen, MJ; Stehouwer, CD; van Guldener, C | 1 |
| Bignell, MK; Bullemer, FE; Graham, KJ; Hanson, NQ; Rasmussen, R; Schwichtenberg, K; Tsai, MY; Vessey, J; Welge, BG; Yang, F | 1 |
| Banga, JD; Biesma, DH; Duran, M; Haas, FJ; Meuwissen, OJ; van der Griend, R | 1 |
| Moustapha, A; Robinson, K | 1 |
| Carlberg, B; Dahlén, G; Hultdin, J; Kristensen, B; Malm, J; Nilsson, TK; Olsson, T | 1 |
| Alders, D; de Jong, SC; Jakobs, C; Kostense, PJ; Pals, G; Rauwerda, JA; Stehouwer, CD; van den Berg, M | 1 |
| Aarnoudse, JG; Lubbers, MF; van Doormaal, JJ | 1 |
| Abeling, NG; Bakker, HD; Blom, H; van Gennip, AH; van Tinteren, HL; Vreken, P; Wevers, RA | 1 |
| Boers, GH; de Jong, SC; Devillé, W; Jakobs, C; Pals, G; Rauwerda, JA; Stehouwer, CD; van den Berg, M | 1 |
| Allaman, M; Browning, RL; Haynes, WG; Kanani, PM; Knapp, HR; Sinkey, CA | 1 |
| Gravel, RA; Leclerc, D; Rosenblatt, DS; Wilson, A | 1 |
| Augier, T; Bescond, A; Chareyre, C; Charpiot, P; Garçon, D; Hornebeck, W | 1 |
| Donker, AJ; Lambert, J; Rauwerda, JA; Stehouwer, CD; Steyn, M; van den Berg, M | 1 |
| Keller, C; Pietrzik, K; Weiss, N | 1 |
| Amiral, J; Blann, AD; Boisseau, MR; Conri, C; Constans, J; Guérin, V; Parrot, F; Renard, M; Resplandy, F; Seigneur, M | 1 |
| Chao, CL; Chien, KL; Lee, YT | 1 |
| Chao, CL; Kuo, TL; Lee, YT | 1 |
| Bulterjis, EJ; de Jong, SC; Jakobs, CA; Mackaay, AJ; Rauwerda, JA; Stehouwer, CD; Twisk, JW; van Campen, CM; van den Berg, M; Vermeulen, EG; Visser, FC | 1 |
| de Jong, SC; Erix, P; Jakobs, C; Rauwerda, JA; Stehouwer, CD; Twisk, JW; Vermeulen, EG; Witjes, RJ | 1 |
| Brouwer, IA; Duran, M; Eskes, TK; Hautvast, JG; Steegers-Theunissen, RP; Thomas, CM; van Dusseldorp, M | 1 |
| Quéré, I | 1 |
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| Bode-Böger, SM; Böger, RH; Heistad, DD; Lentz, SR; Sydow, K | 1 |
| Law, MR; Wald, NJ | 1 |
| Betts, V; Collins, PB; Graham, I; Meleady, R | 1 |
| Booth, GL; Wang, EE | 1 |
| Smulders, YM | 1 |
| Refsum, H; Schneede, J; Ueland, PM | 1 |
| Stehouwer, CD; van Guldener, C | 2 |
| Robinson, K; van Guldener, C | 1 |
| Verhoef, P | 1 |
| Boers, GH; Naughten, ER; Wilcken, B; Wilcken, DE; Yap, S | 1 |
| Graefe, U; Henning, BF; Tepel, M; Zidek, W | 1 |
| Bleich, S; Degner, D; Javaheripour, K; Kornhuber, J; Kurth, C; Quintela-Schneider, M; Rüther, E; Spilker, K; Wiltfang, J | 1 |
| Kurihara, H; Kurihara, Y; Morita, H; Nagai, R; Oh-Hashi, Y; Saito, Y; Shindo, T; Yazaki, Y; Yoshida, S | 1 |
| Bieglmayer, C; Födiger, M; Hörl, WH; Ignatescu, MC; Kletzmayr, J; Sunder-Plassmann, G | 1 |
| Bode-Böger, SM; Böger, RH; Haynes, WG; Knapp, HR; Lentz, SR | 1 |
| Boon, NA; Labinjoh, C; MacCallum, H; Megson, IL; Melville, V; Newby, DE; Webb, DJ; Wilkinson, IB | 1 |
| Banga, JD; Biesma, DH; van der Griend, R | 2 |
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| Anderstam, B; Bárány, P; Bergström, J; Filho, JC; Lindholm, B; Suliman, ME | 1 |
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| Chenard, C; Haynes, WG; Raghuveer, G; Sinkey, CA; Stumbo, P | 1 |
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50 review(s) available for methionine and Hyperhomocysteinemia
| Article | Year |
|---|---|
Hyperhomocysteinemia and cardiovascular diseases.
Topics: Cardiovascular Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Risk Factors | 2022 |
Folate and retinal vascular diseases.
Topics: Diabetic Retinopathy; Endothelial Cells; Folic Acid; Glucose; Homocysteine; Humans; Hyperhomocysteinemia; Methionine | 2023 |
The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment.
Topics: Alzheimer Disease; Brain; Cerebrovascular Circulation; Cognitive Dysfunction; Diet; Humans; Hyperhomocysteinemia; Methionine | 2023 |
Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery.
Topics: Betaine; Cardiovascular Diseases; Choline; Dietary Supplements; DNA Methylation; Eating; Epigenesis, Genetic; Folic Acid; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Methionine; Nutritional Physiological Phenomena; Renal Insufficiency, Chronic; Uremia; Vitamin B 12; Vitamin B 6 | 2020 |
Gut microbiota and the periodontal disease: role of hyperhomocysteinemia.
Topics: Dysbiosis; Folic Acid; Gastrointestinal Microbiome; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Periodontitis; Probiotics | 2021 |
Sulfur-Containing Amino Acids and Lipid Metabolism.
Topics: Amino Acids, Sulfur; Animals; Atherosclerosis; Betaine; Cholesterol; Cysteine; Dietary Proteins; Dietary Supplements; Fatty Liver; Glutathione; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Lipid Metabolism; Methionine; Nutritional Requirements; Nutritional Status; Phosphatidylcholines; Sulfur; Sulfur Compounds; Taurine | 2020 |
Metabolic Consequences of Supplemented Methionine in a Clinical Context.
Topics: Animals; Body Fluid Compartments; Cardiovascular Diseases; Dietary Supplements; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Proteins; Vitamin B Complex; Vitamin B Deficiency | 2020 |
Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis.
Topics: Betaine-Homocysteine S-Methyltransferase; Biomarkers; Body Composition; Body Mass Index; Cystathionine beta-Synthase; Diet, Protein-Restricted; Dietary Proteins; Homeostasis; Homocysteine; Humans; Hyperhomocysteinemia; Liver; Methionine; S-Adenosylmethionine | 2017 |
Hyperhomocysteinemia and cardiovascular disease in animal model.
Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Risk Factors | 2018 |
The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art.
Topics: Atherosclerosis; Cardiovascular Diseases; Endothelial Cells; Homocysteine; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Methionine; Nitric Oxide; Reactive Oxygen Species; S-Adenosylhomocysteine | 2019 |
Methyl nutrients, DNA methylation, and cardiovascular disease.
Topics: Amino Acids; Atherosclerosis; Cardiovascular Diseases; Cysteine; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Humans; Hyperhomocysteinemia; Lipid Metabolism; Methionine; Nutritional Status; Risk Factors; S-Adenosylmethionine; Vitamin B Complex | 2014 |
Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology.
Topics: Cardiovascular Diseases; Dietary Supplements; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylation; Oxidation-Reduction; Randomized Controlled Trials as Topic; Vitamin B Complex; Vitamin B Deficiency; Vitamins | 2013 |
Homocysteine and DNA methylation: a review of animal and human literature.
Topics: Animals; Case-Control Studies; Diet; Dietary Supplements; DNA Methylation; Female; Folic Acid; Gene Knockout Techniques; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Models, Animal; Vitamin B Complex; Vitamin B Deficiency | 2014 |
Homocysteine, iron and cardiovascular disease: a hypothesis.
Topics: Biomarkers; Cardiovascular Diseases; Cystathionine; Dietary Supplements; Folic Acid; Free Radicals; Homocysteine; Humans; Hyperhomocysteinemia; Iron; Lipoproteins, LDL; Methionine; Risk Factors; S-Adenosylhomocysteine; Vitamin B Complex | 2015 |
Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer's Disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alzheimer Disease; Animals; Cystathionine beta-Synthase; Evidence-Based Medicine; Ferredoxin-NADP Reductase; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Hyperhomocysteinemia; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Mutagenesis, Insertional; Nutrigenomics; Nutritional Status; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Tandem Repeat Sequences; Vitamin B Complex; Vitamin B Deficiency | 2016 |
Mechanisms of cardiovascular remodeling in hyperhomocysteinemia.
Topics: Animals; Cardiovascular Diseases; Cardiovascular System; Homocysteine; Humans; Hyperhomocysteinemia; Matrix Metalloproteinases; Methionine; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species | 2011 |
The nutritional burden of methylation reactions.
Topics: Animals; Betaine; Cardiovascular Diseases; Choline; Creatine; Diet; Dietary Supplements; Folic Acid; Humans; Hyperhomocysteinemia; Methionine; Methylation; Nutritional Status; Phosphatidylcholines | 2013 |
Methods for measuring sulfur amino acid metabolism.
Topics: Amino Acids, Sulfur; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Kinetics; Methionine; Methylation; Models, Biological; Radioisotope Dilution Technique; Vitamin B 12 | 2002 |
In vivo stable isotope measurements of methyl metabolism: applications in pathophysiology and interventions.
Topics: Deuterium Oxide; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Infusions, Intravenous; Kidney Failure, Chronic; Methionine; Methylation; Serine; Tomography, Emission-Computed; Tritium | 2002 |
Pharmacotherapy of hyperhomocysteinaemia in patients with thrombophilia.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Pyridoxine; Renal Insufficiency; Thrombophilia; Vitamin B 12; Vitamins | 2002 |
The methionine-homocysteine cycle and its effects on cognitive diseases.
Topics: Alzheimer Disease; Cardiovascular Diseases; Cognition Disorders; Dementia, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Memory Disorders; Methionine; Methionine Adenosyltransferase; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 | 2003 |
Hyperhomocysteinemia, vascular function and atherosclerosis: effects of vitamins.
Topics: Arteriosclerosis; Avitaminosis; Coronary Disease; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Kidney Failure, Chronic; Methionine; Risk Factors; Thrombosis; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency; Vitamins | 2002 |
[Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease?. 1. Basic data].
Topics: Animals; Arteriosclerosis; Biomarkers; Cystathionine beta-Synthase; Folic Acid Deficiency; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Nitric Oxide; Oxidative Stress; Oxidoreductases Acting on CH-NH Group Donors; Rats; Risk Factors; S-Adenosylmethionine; Signal Transduction; Thrombophilia; Vascular Diseases; Vasodilation; Vitamin B 6 Deficiency | 2003 |
Betaine in human nutrition.
Topics: Animals; Betaine; Cardiovascular Diseases; DNA Methylation; Gastrointestinal Agents; Humans; Hyperhomocysteinemia; Intestinal Absorption; Kidney Diseases; Lipotropic Agents; Liver; Liver Diseases; Methionine; Methyltransferases; Osmolar Concentration | 2004 |
Homocysteine remethylation and trans-sulfuration.
Topics: Animals; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylation; Sulfur | 2004 |
Homocysteine: overview of biochemistry, molecular biology, and role in disease processes.
Topics: Animals; Disease Progression; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Oxidation-Reduction | 2005 |
Mechanisms of the atherogenic effects of elevated homocysteine in experimental models.
Topics: Animals; Arteriosclerosis; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Hyperhomocysteinemia; Methionine; Mice; Nitric Oxide; Oxidative Stress; Risk Factors | 2005 |
Mechanisms of homocysteine-induced atherothrombosis.
Topics: Animals; Apolipoproteins E; Apoptosis; Arginine; Atherosclerosis; Coronary Thrombosis; Cysteine; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Models, Biological; Nitric Oxide; Oxidative Stress; Oxygen; Phenotype; Signal Transduction | 2005 |
Hyperhomocysteinemia and response of methionine cycle intermediates to vitamin treatment in renal patients.
Topics: Animals; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Methionine; Methylation; Vitamins | 2005 |
The use of betaine in the treatment of elevated homocysteine.
Topics: Amino Acid Metabolism, Inborn Errors; Betaine; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methionine; Methylation | 2006 |
[Risk factors for cardiovascular diseases: what is the role for homocysteine?].
Topics: Cardiovascular Diseases; Folic Acid; Follow-Up Studies; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Prospective Studies; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors; Vitamin B 12; Vitamin B 6 | 2007 |
[Homocysteine metabolism].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine-Homocysteine S-Methyltransferase; Cardiovascular Diseases; Deuterium; Gas Chromatography-Mass Spectrometry; Gout; Homocysteine; Humans; Hyperhomocysteinemia; Isotope Labeling; Methionine; Oxidation-Reduction; Risk Factors; Serum Albumin; Vitamin B 12 | 2007 |
Mecobalamin.
Topics: Aged; Alprostadil; Animals; Cobamides; Coenzymes; Diabetic Neuropathies; Drug Administration Routes; Drug Therapy, Combination; Female; Folic Acid; Humans; Hyperhomocysteinemia; Hypoglycemic Agents; Kidney Failure, Chronic; Male; Metformin; Methionine; Methyltransferases; Peripheral Nervous System Diseases; Randomized Controlled Trials as Topic; Renal Dialysis; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 | 2008 |
Hyperhomocysteinemia, atherosclerosis and thrombosis.
Topics: Adult; Aged; Animals; Arteriosclerosis; Avitaminosis; Case-Control Studies; Clinical Trials as Topic; Cohort Studies; Cross-Sectional Studies; Cystathionine beta-Synthase; Female; Folic Acid; Gene Frequency; Homocysteine; Homocystinuria; Hormone Replacement Therapy; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Muscle, Smooth, Vascular; Oxidoreductases Acting on CH-NH Group Donors; Prevalence; Primates; Prospective Studies; Pyridoxine; Risk Factors; Smoking; Tamoxifen; Thrombophilia; Thrombosis; Vitamin B 12 | 1999 |
Homocysteine: an emerging age-related cardiovascular risk factor.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Cardiovascular Diseases; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Menopause; Methionine; Middle Aged; Prevalence; Primary Health Care; Risk Factors | 1999 |
[Hyperhomocysteinemia, a risk factor for atherosclerosis: causes and effects].
Topics: Age Factors; Arterial Occlusive Diseases; Arteriosclerosis; Cerebrovascular Disorders; Coronary Disease; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipid Metabolism; Lipoproteins; Male; Meta-Analysis as Topic; Methionine; Middle Aged; Peripheral Vascular Diseases; Prospective Studies; Pyridoxine; Randomized Controlled Trials as Topic; Risk Factors; Sex Factors | 1999 |
Homocysteine and ischaemic heart disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Cohort Studies; Comorbidity; Cystathionine beta-Synthase; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Ischemia; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Retrospective Studies | 1999 |
Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care.
Topics: Aged; Arteriosclerosis; Canada; Coronary Disease; Dietary Supplements; Disease Susceptibility; Fasting; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mass Screening; Methionine; Preventive Medicine; Pyridoxine; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B 12 | 2000 |
Biological and environmental determinants of plasma homocysteine.
Topics: Adult; Aged; Aging; Alcohol Drinking; Child; Cystathionine beta-Synthase; Diagnosis-Related Groups; Dietary Proteins; Endocrine System Diseases; Female; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Inflammation; Intestinal Diseases; Life Style; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasms; Niacin; Nitrous Oxide; Norway; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Renal Insufficiency; Smoking; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2000 |
Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction.
Topics: Adult; Animals; Arteriosclerosis; Biomarkers; Blood Vessels; Cardiovascular Diseases; Carotid Stenosis; Child; Comorbidity; Coronary Angiography; Endothelium, Vascular; Female; Genetic Predisposition to Disease; Genotype; Homocystinuria; Humans; Hyperhomocysteinemia; Hyperplasia; Hypertension; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Prevalence; Rabbits; Rats; Vasodilation | 2000 |
Homocysteine and renal disease.
Topics: Adult; Arteriosclerosis; Cardiovascular Diseases; Case-Control Studies; Child; Endothelium, Vascular; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplantation; Life Tables; Male; Methionine; Peritoneal Dialysis; Prospective Studies; Pyridoxine; Renal Dialysis; Survival Analysis; Thrombophilia; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2000 |
Hyperhomocysteinemia and risk of vascular disease in women.
Topics: Adult; Age Factors; Aged; Arteriosclerosis; Body Mass Index; Case-Control Studies; Cohort Studies; Comorbidity; Confounding Factors, Epidemiologic; Cross-Sectional Studies; Fasting; Female; Follow-Up Studies; Humans; Hyperhomocysteinemia; Incidence; Male; Methionine; Middle Aged; Multicenter Studies as Topic; Postmenopause; Premenopause; Prospective Studies; Risk; Risk Factors; Sex Factors; Vascular Diseases | 2000 |
Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy.
Topics: Adolescent; Adult; Aged; Australia; Child; Child, Preschool; Cohort Studies; Cystine; Drug Resistance; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Infant; Ireland; Male; Methionine; Middle Aged; Netherlands; Pyridoxine; Risk; Risk Factors; Thrombophilia; Vascular Diseases; Vitamin B 12 | 2000 |
Clotting disorders and placental abruption: homocysteine--a new risk factor.
Topics: Abruptio Placentae; Blood Coagulation Disorders; Endothelium, Vascular; Female; Fetal Growth Retardation; Folic Acid; Heart Defects, Congenital; Humans; Hyperhomocysteinemia; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors; Pregnancy; Pregnancy Complications, Hematologic; Risk Factors | 2001 |
[From gene to disease; from homocysteine to hyperhomocysteinemia].
Topics: Cystathionine beta-Synthase; Folic Acid; Heterozygote; Homocysteine; Homocystinuria; Homozygote; Humans; Hyperhomocysteinemia; Methionine; Mutation; Risk Factors; Vascular Diseases | 2001 |
Roles of homocysteine in cell metabolism: old and new functions.
Topics: Cardiovascular Diseases; Cell Physiological Phenomena; Female; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylation; Nervous System Malformations; Pregnancy; Pregnancy Complications; RNA, Transfer, Amino Acyl; S-Adenosylmethionine | 2001 |
Homocysteine-lowering treatment: an overview.
Topics: Animals; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Vitamin B Deficiency; Vitamins | 2001 |
Vascular dysfunction in hyperhomocyst(e)inemia. Implications for atherothrombotic disease.
Topics: Endothelium, Vascular; Free Radicals; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Models, Biological; Models, Chemical; Oxidative Stress; Vascular Diseases; Venous Thrombosis | 2001 |
Postmethionine-load homocysteine determination for the diagnosis hyperhomocysteinaemia and efficacy of homocysteine lowering treatment regimens.
Topics: Cardiovascular Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Randomized Controlled Trials as Topic; Risk Factors; Treatment Outcome | 2002 |
Hormones and homocysteine.
Topics: Diabetic Angiopathies; Homocysteine; Hormones; Humans; Hyperhomocysteinemia; Hyperlipidemias; Methionine; Vascular Diseases | 2002 |
38 trial(s) available for methionine and Hyperhomocysteinemia
| Article | Year |
|---|---|
Pirfenidone alleviates vascular intima injury caused by hyperhomocysteinemia.
Topics: Animals; Antioxidants; Glutathione Peroxidase; Homocysteine; Hyperhomocysteinemia; Hyperplasia; Lipids; Malondialdehyde; Methionine; Oxidants; Pyridones; Rabbits; Reactive Oxygen Species; Superoxide Dismutase; Tunica Intima | 2022 |
Hyperhomocysteinaemia and the risk of recurrent venous thrombosis: results from the MEGA follow-up study.
Topics: Adolescent; Adult; Aged; Female; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Recurrence; Risk Factors; Venous Thrombosis | 2019 |
The effect of hyperhomocysteinemia on aortic distensibility in healthy individuals.
Topics: Administration, Oral; Adult; Aorta; Blood Pressure; Cardiovascular Diseases; Cross-Over Studies; Elasticity; Female; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pulse Wave Analysis | 2013 |
Different responses of the retinal and cutaneous microcirculation to transient dysmetabolic conditions.
Topics: Acetylcholine; Administration, Cutaneous; Adult; Dietary Fats; Germany; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Iontophoresis; Laser-Doppler Flowmetry; Light; Male; Methionine; Microcirculation; Microvessels; Photic Stimulation; Predictive Value of Tests; Regional Blood Flow; Reproducibility of Results; Retinal Vessels; Skin; Vasodilation; Vasodilator Agents; Young Adult | 2015 |
Acute hyperlipidemia but not hyperhomocysteinemia impairs reflex regulation of the cardiovascular system.
Topics: Adrenergic beta-Agonists; Adult; Baroreflex; Blood Pressure; Cardiovascular System; Dietary Fats; Germany; Heart Rate; Hemodynamics; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Male; Methionine; Sympathetic Nervous System; Time Factors; Vagus Nerve; Vasodilator Agents; Young Adult | 2015 |
Homocysteinemia control by cysteine in cerebral vascular patients after methionine loading test: evidences in physiological and pathological conditions in cerebro-vascular and multiple sclerosis patients.
Topics: Adult; Cerebrovascular Disorders; Cysteine; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Multiple Sclerosis; Serum Albumin, Human | 2016 |
Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels.
Topics: Analysis of Variance; Antioxidants; Ascorbic Acid; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Fasting; Female; Forearm; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins, LDL; Male; Methionine; Oxidative Stress; Regional Blood Flow; Vitamin E | 2008 |
The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals.
Topics: Adult; Ascorbic Acid; Double-Blind Method; Endothelin-1; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methionine; Oxidative Stress; Signal Transduction; Vasodilation; Vitamin E | 2010 |
Acute hyperhomocysteinemia impairs endothelium function in subjects with type 2 diabetes mellitus.
Topics: Aged; Blood Glucose; Blood Pressure; Brachial Artery; Cholesterol; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Heart Rate; Homocysteine; Humans; Hyperhomocysteinemia; Luteal Phase; Male; Methionine; Middle Aged; Triglycerides; Vasodilation; Water | 2010 |
Homocysteine impairs coronary microvascular dilator function in humans.
Topics: Adenosine; Adult; Coronary Circulation; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Reference Values; Tomography, Emission-Computed; Vasodilator Agents | 2002 |
Post-methionine-load hyperhomocysteinemia and increased lipoprotein(a) are associated with renal metabolic dysfunction: a hypothesis.
Topics: Apolipoproteins A; Creatinine; Folic Acid; Humans; Hyperhomocysteinemia; Kidney Diseases; Lipoprotein(a); Male; Methionine; Middle Aged; Vitamin B 12 | 2002 |
The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs.
Topics: Adult; Anticonvulsants; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Epilepsy; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; Methionine; Middle Aged; Pyridoxic Acid; Riboflavin; Selectins; Vascular Cell Adhesion Molecule-1; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2002 |
Effects of acute hyperhomocysteinemia on the neurovascular coupling mechanism in healthy young adults.
Topics: Acute Disease; Adult; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cross-Over Studies; Diastole; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Photic Stimulation; Posterior Cerebral Artery; Reference Values; Systole; Ultrasonography, Doppler, Transcranial | 2003 |
Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.
Topics: Adult; Age Factors; Aged; Arginine; Arteriosclerosis; Brachial Artery; Endothelium, Vascular; Female; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Peripheral Vascular Diseases; Regional Blood Flow; Regression Analysis; Vasodilation | 2003 |
A 2-step strategy to reduce the need for methionine-loading tests to diagnose hyperhomocysteinemia.
Topics: Adult; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Prospective Studies; Reproducibility of Results; Sensitivity and Specificity | 2003 |
Acute hyperhomocysteinemia induces a reduction in arterial distensibility and compliance.
Topics: Acute Disease; Adult; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Compliance; Cross-Over Studies; Double-Blind Method; Femoral Artery; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Oxidative Stress; Regional Blood Flow; Time Factors; Vasodilation | 2004 |
Changes in basal and postmethionine load concentrations of total homocysteine and cystathionine after B vitamin intervention.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analysis of Variance; Cardiovascular Diseases; Cystathionine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Norway; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2004 |
Impairment of coronary circulation by acute hyperhomocysteinaemia and reversal by antioxidant vitamins.
Topics: Adult; Antioxidants; Coronary Circulation; Coronary Disease; Cross-Over Studies; Cytokines; Female; Humans; Hyperhomocysteinemia; Male; Methionine; Vitamins | 2004 |
Evaluation of a shorter methionine loading test.
Topics: Administration, Oral; Adult; Cardiovascular Diseases; Chelating Agents; Edetic Acid; Fasting; Female; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Linear Models; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pre-Eclampsia; Pregnancy; Risk Factors; Time Factors | 2004 |
Effect of acute hyperhomocysteinemia on coronary flow reserve in healthy adults.
Topics: Acute Disease; Adult; Blood Flow Velocity; Coronary Circulation; Coronary Vessels; Cross-Over Studies; Echocardiography, Doppler; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Placebos | 2004 |
Effect of hyperhomocysteinemia induced by methionine administration on flow-mediated dilatation of the brachial artery in healthy subjects.
Topics: Administration, Oral; Adult; Brachial Artery; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperhomocysteinemia; Linear Models; Male; Methionine; Ultrasonography, Doppler | 2005 |
Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia.
Topics: Acetylcysteine; Adult; Arginine; Blood Flow Velocity; Brachial Artery; Cross-Over Studies; Cystathionine; Cysteine; Dipeptides; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kinetics; Male; Methionine; Placebos; S-Adenosylhomocysteine; S-Adenosylmethionine; Vasodilation | 2005 |
Experimental hyperhomocysteinemia impairs coronary flow velocity reserve.
Topics: Adenosine Triphosphate; Administration, Oral; Adult; Antioxidants; Ascorbic Acid; Biomarkers; Blood Flow Velocity; Coronary Circulation; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Oxidative Stress; Reference Values; Research Design; Superoxide Dismutase; Time Factors | 2005 |
Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines.
Topics: Adult; alpha-Tocopherol; Arginine; Ascorbic Acid; Cholesterol, LDL; Chronic Disease; Cytokines; Double-Blind Method; Endothelium, Vascular; Female; Forearm; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Interleukin-6; Male; Methionine; Oxidative Stress; Time Factors; Vascular Resistance; von Willebrand Factor | 2006 |
Lack of significant effects of methionine loading on endothelial function in elderly volunteers.
Topics: Aged; Aged, 80 and over; Brachial Artery; C-Reactive Protein; Cholesterol; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins; Methionine; Placebos; Regional Blood Flow; Time Factors; Triglycerides | 2006 |
Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults.
Topics: Administration, Oral; Adult; Brachial Artery; Cross-Over Studies; Endothelium, Vascular; Female; Humans; Hyperhomocysteinemia; Male; Methionine; Reference Values; Regional Blood Flow; Time Factors; Vasodilation | 1998 |
Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy.
Topics: Adult; Ascorbic Acid; Blood Flow Velocity; Brachial Artery; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Oxidative Stress; Time Factors | 1999 |
Effect of folic acid and betaine on fasting and postmethionine-loading plasma homocysteine and methionine levels in chronic haemodialysis patients.
Topics: Adult; Betaine; Fasting; Female; Folic Acid; Hematinics; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methionine; Methylation; Middle Aged; Renal Dialysis; Time Factors; Treatment Outcome | 1999 |
Variability of fasting and post-methionine plasma homocysteine levels in normo- and hyperhomocysteinaemic individuals.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Analysis of Variance; Fasting; Female; Folic Acid; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases; Statistics, Nonparametric | 1999 |
Endothelial dysfunction during acute methionine load in hyperhomocysteinaemic patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Arteriosclerosis; Biomarkers; Endothelium, Vascular; Female; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; P-Selectin; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Thrombomodulin; von Willebrand Factor | 1999 |
Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial.
Topics: Blood Pressure; Coronary Artery Disease; Family; Female; Folic Acid; Hematinics; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxine; Risk Factors | 2000 |
Low-dose folic acid supplementation does not influence plasma methionine concentrations in young non-pregnant women.
Topics: Adolescent; Adult; Contraceptives, Oral; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Vitamin B 12 | 1999 |
Oxidative stress and an altered methionine metabolism in alcoholism.
Topics: Adult; Aged; Alcoholism; Chlormethiazole; Chromatography, High Pressure Liquid; Chronic Disease; Ethanol; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypnotics and Sedatives; Lipid Peroxidation; Male; Malondialdehyde; Methionine; Middle Aged; Oxidative Stress | 2000 |
Effects of acute methionine loading and vitamin C on endogenous fibrinolysis, endothelium-dependent vasomotion and platelet aggregation.
Topics: Acute Disease; Adult; Ascorbic Acid; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Fibrinolysis; Forearm; Humans; Hyperhomocysteinemia; Male; Methionine; Nitroprusside; Platelet Aggregation; Regional Blood Flow; Substance P; Tissue Plasminogen Activator; Vasodilation; Vasodilator Agents | 2001 |
Fenofibrate raises plasma homocysteine levels in the fasted and fed states.
Topics: Adult; Coronary Artery Disease; Dairy Products; Dietary Fats; Double-Blind Method; Eating; Fasting; Fenofibrate; Humans; Hyperhomocysteinemia; Hypertriglyceridemia; Hypolipidemic Agents; Lipids; Male; Methionine; Middle Aged; Risk Factors | 2001 |
The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia.
Topics: Acetylcholine; Administration, Oral; Adult; Area Under Curve; Ascorbic Acid; Cross-Over Studies; Endothelium, Vascular; Forearm; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Intra-Arterial; Male; Methionine; Oxidative Stress; Plethysmography; Regional Blood Flow; Single-Blind Method; Vasodilation | 2001 |
Effect of vitamin E on resistance vessel endothelial dysfunction induced by methionine.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Humans; Hyperhomocysteinemia; Male; Methionine; Regional Blood Flow; Vascular Resistance; Vasodilation; Vitamin E | 2001 |
Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure.
Topics: Aged; Betaine; Cross-Over Studies; Drug Therapy, Combination; Fasting; Female; Folic Acid; Hematinics; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Lipids; Male; Methionine; Middle Aged; Pyridoxine; Sarcosine | 2002 |
299 other study(ies) available for methionine and Hyperhomocysteinemia
| Article | Year |
|---|---|
Consumption of Cashew (
Topics: Anacardium; Animals; Antioxidants; Hyperhomocysteinemia; Inflammation; Methionine; Nuts; Oxidative Stress; Rats | 2022 |
A chronic moderate methionine administration induced hyperhomocysteinemia associated with cardiovascular disease phenotype in the sand rat Psammomys obesus.
Topics: Animals; Cardiovascular Diseases; Gerbillinae; Hyperhomocysteinemia; Methionine; Phenotype | 2022 |
Vitamin B
Topics: Animals; Fatty Acids; Fibrosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Qa-SNARE Proteins; Vitamin B 12; Vitamins | 2022 |
Hyperhomocysteinemia in acute hepatic porphyria (AHP) and implications for treatment with givosiran.
Topics: Clinical Trials as Topic; Cystathionine beta-Synthase; Folic Acid; Heme; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Porphyrias, Hepatic; Pyridoxine; RNA, Small Interfering; Sulfur; Vitamin B 6 | 2022 |
Epigallocatechin-3-gallate Enhances Cognitive and Memory Performance and Protects Against Brain Injury in Methionine-induced Hyperhomocysteinemia Through Interdependent Molecular Pathways.
Topics: Animals; Apoptosis Regulatory Proteins; Brain Injuries; Catechin; Cognition; Hyperhomocysteinemia; Male; Methionine; Mice; Oxidative Stress; Racemethionine | 2022 |
Hyperhomocysteinemia activates NLRP3 inflammasome to cause hepatic steatosis and insulin resistance via MDM2-mediated ubiquitination of HSF1.
Topics: Animals; Heat Shock Transcription Factors; Hyperhomocysteinemia; Inflammasomes; Insulin Resistance; Liver; Methionine; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Ubiquitination | 2023 |
Alzheimer's Disease-like Pathological Features in the Dorsal Hippocampus of Wild-Type Rats Subjected to Methionine-Diet-Evoked Mild Hyperhomocysteinaemia.
Topics: Alzheimer Disease; Animals; Diet; Epigenesis, Genetic; Hippocampus; Hyperhomocysteinemia; Male; Methionine; Racemethionine; Rats; Rats, Wistar | 2023 |
Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling.
Topics: Cytosol; Gene Regulatory Networks; Histones; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylation; Protein Interaction Maps; Protein Transport | 2020 |
Homocysteine accelerates atherosclerosis by inhibiting scavenger receptor class B member1 via DNMT3b/SP1 pathway.
Topics: Animals; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Diet; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Down-Regulation; Foam Cells; HEK293 Cells; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Plaque, Atherosclerotic; Promoter Regions, Genetic; Protein Binding; Signal Transduction; Sp1 Transcription Factor; THP-1 Cells | 2020 |
Effect of Methionine Diet on Metabolic and Histopathological Changes of Rat Hippocampus.
Topics: Animals; Disease Models, Animal; Hippocampus; Hyperhomocysteinemia; Male; Metabolome; Methionine; Organ Size; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Wistar | 2019 |
Edaravone protects from memory impairment induced by chronic L-methionine administration.
Topics: Animals; Antioxidants; Dementia, Vascular; Disease Models, Animal; Edaravone; Free Radical Scavengers; Hippocampus; Hyperhomocysteinemia; Male; Maze Learning; Memory Disorders; Methionine; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar | 2020 |
Neurotrophins of the Fetal Brain and Placenta in Prenatal Hyperhomocysteinemia.
Topics: Animals; Brain; Cytokines; Female; Hyperhomocysteinemia; Methionine; Nerve Growth Factors; Nervous System; Placenta; Pregnancy; Rats; Rats, Wistar | 2020 |
Hyperhomocysteinemia-Induced Oxidative Stress Exacerbates Cortical Traumatic Brain Injury Outcomes in Rats.
Topics: Animals; Anxiety; Behavior, Animal; Blood Coagulation; Blood-Brain Barrier; Brain Injuries, Traumatic; Cerebral Cortex; Homocysteine; Hyperhomocysteinemia; Inflammation; Intercellular Adhesion Molecule-1; Male; Methionine; Occludin; Oxidative Stress; Rats, Sprague-Dawley; Tyrosine; Zonula Occludens-1 Protein | 2021 |
Maternal Hyperhomocysteinemia Induces Neuroinflammation and Neuronal Death in the Rat Offspring Cortex.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Caspase 3; Cerebral Cortex; Disease Models, Animal; Female; Hyperhomocysteinemia; Inflammation; Interleukin-1beta; Interleukin-6; Methionine; Neuroglia; Neurons; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pregnancy Complications; Rats; Tumor Necrosis Factor-alpha | 2020 |
Effect of Methionine Diet on Time-Related Metabolic and Histopathological Changes of Rat Hippocampus in the Model of Global Brain Ischemia.
Topics: Animals; Brain Ischemia; Diet; Hippocampus; Homocysteine; Hyperhomocysteinemia; Magnetic Resonance Spectroscopy; Male; Methionine; Rats; Rats, Wistar | 2020 |
Tadalafil ameliorates memory deficits, oxidative stress, endothelial dysfunction and neuropathological changes in rat model of hyperhomocysteinemia induced vascular dementia.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain; Cyclic Nucleotide Phosphodiesterases, Type 5; Dementia, Vascular; Hyperhomocysteinemia; Maze Learning; Memory Disorders; Methionine; Nitrites; Oxidative Stress; Phosphodiesterase 5 Inhibitors; Rats; Rats, Wistar; Tadalafil | 2022 |
Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran.
Topics: Acetylgalactosamine; Adult; Arginine; Cystathionine beta-Synthase; Female; Folic Acid; Heme; Homeostasis; Homocysteine; Homocystinuria; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Porphyria, Acute Intermittent; Pyridoxal Phosphate; Pyrrolidines; Young Adult | 2021 |
Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats.
Topics: Animals; Anxiety; Behavior, Animal; Cortical Excitability; Cortical Spreading Depression; Disease Models, Animal; Female; Hyperalgesia; Hyperhomocysteinemia; Male; Methionine; Migraine with Aura; Photophobia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Somatosensory Cortex | 2021 |
Methionine Diet Evoked Hyperhomocysteinemia Causes Hippocampal Alterations, Metabolomics Plasma Changes and Behavioral Pattern in Wild Type Rats.
Topics: Animals; Behavior, Animal; Hippocampus; Homocysteine; Hyperhomocysteinemia; In Situ Nick-End Labeling; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methionine; Rats, Wistar; Staining and Labeling | 2021 |
Prenatal Hyperhomocysteinemia Induces Glial Activation and Alters Neuroinflammatory Marker Expression in Infant Rat Hippocampus.
Topics: Acetylcholinesterase; Animals; Animals, Newborn; Biomarkers; Brain; Caspase 3; Cytokines; Female; Hippocampus; Hyperhomocysteinemia; Inflammation; Interleukin-1beta; Interleukin-6; Methionine; Neuroglia; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 2021 |
Homocysteine Induces Hepatic Steatosis Involving ER Stress Response in High Methionine Diet-Fed Mice.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cells, Cultured; Endoplasmic Reticulum Stress; Gene Expression Regulation; Hepatocytes; Homocysteine; Hyperhomocysteinemia; Lipogenesis; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Organ Size; Phenylbutyrates; Random Allocation; Tunicamycin | 2017 |
Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny.
Topics: Animals; Antioxidants; Arcuate Nucleus of Hypothalamus; Catecholamines; Estrous Cycle; Female; Gonadotropin-Releasing Hormone; Hyperhomocysteinemia; Luteinizing Hormone; Median Eminence; Melatonin; Methionine; Neuroprotective Agents; Norepinephrine; Pregnancy; Prenatal Exposure Delayed Effects; Preoptic Area; Progesterone; Rats; Rats, Wistar | 2017 |
Reciprocal Regulation Between miR-148a/152 and DNA Methyltransferase 1 Is Associated with Hyperhomocysteinemia-Accelerated Atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cell Line, Tumor; Cholesterol; Cholesterol Esters; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Foam Cells; Humans; Hyperhomocysteinemia; Methionine; Mice; Mice, Inbred C57BL; MicroRNAs; Promoter Regions, Genetic | 2017 |
[A new link between high homocysteine levels, cancers and neurodegenerative diseases].
Topics: Homocysteine; Humans; Hyperhomocysteinemia; Metabolic Networks and Pathways; Methionine; Neoplasms; Neurodegenerative Diseases; Risk Factors | 2017 |
[Metabolic changes in pulmonary mitochondria of rats with experimental hyperhomocysteinemia].
Topics: Animals; Enzyme Inhibitors; Homocysteine; Humans; Hyperhomocysteinemia; L-Lactate Dehydrogenase; Lung; Male; Methionine; Mitochondria; Mitochondrial Proton-Translocating ATPases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Phosphorylation; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxide Dismutase | 2017 |
Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling.
Topics: Animals; Atherosclerosis; Carbazoles; Endothelium, Vascular; Hyperhomocysteinemia; Male; Malondialdehyde; Methionine; Mice; Mice, Inbred C57BL; NADPH Oxidase 1; Neuropeptides; NF-kappa B; Oxidative Stress; Physical Conditioning, Animal; rac1 GTP-Binding Protein; Scavenger Receptors, Class E; Signal Transduction; Sirtuin 1; Superoxide Dismutase; Up-Regulation | 2018 |
Moderate hyperhomocysteinemia induced by short-term dietary methionine overload alters bone microarchitecture and collagen features during growth.
Topics: Animals; Bone and Bones; Bone Development; Bone Matrix; Collagen; Diet; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; X-Ray Microtomography | 2017 |
The Cardiovascular Effect of Systemic Homocysteine Is Associated with Oxidative Stress in the Rostral Ventrolateral Medulla.
Topics: Animals; Blood Pressure; Down-Regulation; Hyperhomocysteinemia; Medulla Oblongata; Methionine; NADPH Oxidase 4; Oxidative Stress; Rats; Reactive Oxygen Species; Superoxide Dismutase; Sympathetic Nervous System; Up-Regulation | 2017 |
Vitamin B complex mitigates cardiac dysfunction in high-methionine diet-induced hyperhomocysteinemia.
Topics: Animals; Catalase; Diet; Glutathione; Heart; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Vitamin B Complex | 2018 |
Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats.
Topics: Acetylcholine; Animals; Diet; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Kidney; Male; Methionine; Nephrectomy; Rats; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Vasodilation | 2018 |
Caffeine Prevents Memory Impairment Induced by Hyperhomocysteinemia.
Topics: Animals; Antioxidants; Caffeine; Catalase; Glutathione; Glutathione Peroxidase; Hippocampus; Hyperhomocysteinemia; Male; Maze Learning; Memory Disorders; Methionine; Rats; Rats, Wistar | 2018 |
Homocysteine and age-associated disorders.
Topics: Aged; Aging; Bone Diseases; Chronic Disease; Hearing Loss; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Quality of Life; Renal Insufficiency; Risk Factors | 2019 |
The immunomodulatory mechanism of brain injury induced by hyperhomocysteinemia in spontaneously hypertensive rats.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Forkhead Transcription Factors; Homocysteine; Humans; Hyperhomocysteinemia; Immunomodulation; Inflammation; Interleukin-10; Interleukin-17; Interleukin-6; Methionine; Nuclear Receptor Subfamily 1, Group F, Member 3; Rats; Rats, Inbred SHR; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Transforming Growth Factor beta | 2019 |
Hyperhomocysteinemia induced endothelial progenitor cells dysfunction through hyper-methylation of CBS promoter.
Topics: Angiogenesis Inducing Agents; Animals; Azacitidine; Bone and Bones; Bone Marrow Cells; Cell Differentiation; Cystathionine beta-Synthase; DNA Methylation; Endothelial Progenitor Cells; Hyperhomocysteinemia; Methionine; Methyltransferases; Mice; Promoter Regions, Genetic; Regional Blood Flow | 2019 |
A novel approach in the management of hyperhomocysteinemia.
Topics: Alcohol Oxidoreductases; Animals; Choline; Cytidine Diphosphate Choline; Dietary Supplements; Endothelial Cells; Folic Acid; Homocysteine; Humans; Hydrolysis; Hyperhomocysteinemia; Kidney; Life Style; Liver; Methionine; Models, Theoretical; Vitamin B 12; Vitamin B 6 | 2019 |
Hyperhomocysteinemia and myocardial remodeling in the sand rat, Psammomys obesus.
Topics: Animals; Apoptosis; Cardiomyopathies; Gerbillinae; Hyperhomocysteinemia; Methionine; Muscle Proteins; Myocardium; Myocytes, Cardiac | 2019 |
Quercetin reduces serum homocysteine level in rats fed a methionine-enriched diet.
Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Glutathione; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Organ Size; Oxidative Stress; Protein Carbonylation; Quercetin; Random Allocation; Rats; Rats, Wistar; Weight Gain | 2013 |
Methionine-induced hyperhomocysteinemia impairs the antioxidant ability of high-density lipoproteins without reducing in vivo macrophage-specific reverse cholesterol transport.
Topics: Animals; Antioxidants; Apolipoprotein A-I; Aryldialkylphosphatase; Atherosclerosis; Biological Transport; Cell Line; Cholesterol, HDL; Disease Models, Animal; Female; Homocysteine; Hyperhomocysteinemia; Lipid Metabolism; Liver; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2013 |
Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: role of folic acid.
Topics: Adenosylhomocysteinase; Animals; Blood-Brain Barrier; Cystathionine beta-Synthase; Diet; Epigenesis, Genetic; Folic Acid; Heterozygote; Hyperhomocysteinemia; Matrix Metalloproteinases; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress | 2014 |
Moderate hyperhomocysteinemia provokes dysfunction of cardiovascular autonomic system and liver oxidative stress in rats.
Topics: Animals; Autonomic Nervous System; Baroreflex; Cardiovascular System; Catalase; Glutathione Peroxidase; Heart Conduction System; Heart Rate; Hyperhomocysteinemia; Hypertension; Lipid Peroxidation; Liver; Male; Methionine; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase | 2014 |
The control of hyperhomocysteinemia through thiol exchange mechanisms by mesna.
Topics: Adult; Antioxidants; Drug Evaluation, Preclinical; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Mesna; Methionine; Middle Aged; Oxidation-Reduction | 2014 |
Validity and reliability of the 13C-methionine breath test for the detection of moderate hyperhomocysteinemia in Mexican adults.
Topics: Adult; Area Under Curve; Body Mass Index; Breath Tests; Carbon Isotopes; Chromatography, High Pressure Liquid; Female; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Middle Aged; Polymorphism, Single Nucleotide; ROC Curve; Sensitivity and Specificity | 2014 |
Bleomycin hydrolase and hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis.
Topics: Animals; Cysteine Endopeptidases; Homeostasis; Hyperhomocysteinemia; Liver; Male; Methionine; Mice, Inbred C57BL; Proteome; Transcriptome | 2014 |
Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.
Topics: Amino Acids, Neutral; Animals; Comorbidity; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Female; Homocystinuria; Hyperhomocysteinemia; Kidney Tubules, Proximal; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Renal Aminoacidurias | 2014 |
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
Topics: Acetylcholinesterase; Animals; Apoptosis; Betaine; Cerebellum; Choline; Choline O-Acetyltransferase; Disease Models, Animal; DNA Methylation; Ferredoxin-NADP Reductase; Gene Expression; Hippocampus; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Male; Memory, Short-Term; Methionine; Mice; Mice, Knockout; Synaptic Transmission | 2014 |
Postacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats.
Topics: Animals; Antioxidants; Apoptosis; Brain Injuries; DNA Fragmentation; Glutathione; Hyperhomocysteinemia; Kisspeptins; Methionine; Neurons; Oxidative Stress; Rats; Superoxide Dismutase | 2014 |
Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease.
Topics: Animals; Blotting, Western; Cysteine Endopeptidases; Diet; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Enzymologic; Genotype; Hyperhomocysteinemia; Isoelectric Focusing; Kidney; Kidney Diseases; Methionine; Mice, Inbred C57BL; Protein Isoforms; Proteins; Reproducibility of Results | 2014 |
Validity and reliability of the 13C-methionine breath test for the detection of moderate hyperhomocysteinemia in Mexican adults; statistical issues in validity and reliability analysis.
Topics: Female; Humans; Hyperhomocysteinemia; Male; Methionine | 2014 |
Homocysteine induces the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-κB signal pathway in rat vascular smooth muscle cells.
Topics: Animals; Atherosclerosis; C-Reactive Protein; Cells, Cultured; Dizocilpine Maleate; Gene Expression Regulation; Homocysteine; Hyperhomocysteinemia; Interleukins; Male; MAP Kinase Signaling System; Methionine; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; NF-kappa B; Onium Compounds; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Superoxides; Thenoyltrifluoroacetone | 2014 |
Hyperhomocysteinemia induced by methionine dietary nutritional overload modulates acetylcholinesterase activity in the rat brain.
Topics: Acetylcholinesterase; Animals; Brain; Diet; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats, Wistar | 2014 |
Central and systemic responses to methionine-induced hyperhomocysteinemia in mice.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Cysteine; Dose-Response Relationship, Drug; Drug Administration Schedule; Glutathione; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Motor Activity; Recognition, Psychology; Time Factors | 2014 |
Homocysteine reduces protein S-nitrosylation in endothelium.
Topics: Animals; Aorta; Endothelium, Vascular; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Hyperhomocysteinemia; Male; Methionine; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein S; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Transcription Factor RelA; Vascular Cell Adhesion Molecule-1 | 2014 |
Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia.
Topics: Animals; Cerebral Arteries; Diet; Disease Models, Animal; Endothelium, Vascular; Female; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Knockout; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Phenotype; Reactive Oxygen Species; Thrombosis; Vasodilator Agents | 2014 |
Hyperhomocysteinemia is a result, rather than a cause, of depression under chronic stress.
Topics: Animals; Behavior, Animal; Betaine-Homocysteine S-Methyltransferase; Chronic Disease; Depression; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats, Wistar; Recombinant Proteins; Sertraline; Stress, Psychological | 2014 |
Paraoxonase 1 and dietary hyperhomocysteinemia modulate the expression of mouse proteins involved in liver homeostasis.
Topics: Animals; Aryldialkylphosphatase; Homeostasis; Hyperhomocysteinemia; Liver; Methionine; Mice | 2014 |
Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism.
Topics: Animals; Apoptosis; Betaine-Homocysteine S-Methyltransferase; Catalase; Chromatography, High Pressure Liquid; Cochlea; Female; Folic Acid; Folic Acid Deficiency; Glutathione Peroxidase; Glutathione Synthase; Hair Cells, Auditory; Hearing Loss; Homocysteine; Hyperhomocysteinemia; In Situ Nick-End Labeling; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidation-Reduction; Oxidative Stress; Phospholipid Hydroperoxide Glutathione Peroxidase | 2015 |
[Catecholamine content in the adrenal gland of rat offspring in the model of prenatal hyperhomocysteinemia].
Topics: Administration, Oral; Adrenal Glands; Animals; Animals, Newborn; Catecholamines; Disease Models, Animal; Female; Hyperhomocysteinemia; Methionine; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Tyrosine | 2014 |
Whey protein supplementation increases methionine intake but not homocysteine plasma concentration in rats.
Topics: Advanced Oxidation Protein Products; Animals; Biomarkers; Caseins; Dietary Supplements; Glutathione; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Methionine; Muscle, Skeletal; Oxidation-Reduction; Oxidative Stress; Random Allocation; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Whey Proteins | 2015 |
L-serine supplementation attenuates alcoholic fatty liver by enhancing homocysteine metabolism in mice and rats.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Dietary Supplements; Energy Intake; Ethanol; Fatty Liver, Alcoholic; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; S-Adenosylmethionine; Serine; Triglycerides | 2015 |
Dietary methionine restriction in mice elicits an adaptive cardiovascular response to hyperhomocysteinemia.
Topics: Adaptation, Physiological; Adiponectin; Adrenergic beta-Agonists; Age Factors; Animals; Apolipoproteins E; Cardiovascular Diseases; Cardiovascular System; Diet; Disease Susceptibility; Fibroblast Growth Factors; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Knockout; Signal Transduction | 2015 |
Nebivolol to attenuate the effects of hyper-homocysteinaemia in rats.
Topics: Animals; Antioxidants; Aorta, Thoracic; Biomarkers; Brain; Catalase; Cytoprotection; Disease Models, Animal; Glutathione; Hyperhomocysteinemia; Kidney; Liver; Male; Malondialdehyde; Methionine; Myocardium; Nebivolol; Oxidative Stress; Rats, Wistar; Superoxide Dismutase; Time Factors; Vascular Remodeling | 2015 |
Dysfunction of blood pressure regulation in hyperhomocyteinemia model in rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Elastic Tissue; Epinephrine; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Oxidation-Reduction; Rats, Sprague-Dawley; Risk Factors; Thiobarbiturates | 2015 |
Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Cathepsin D; Disease Models, Animal; Endothelium, Vascular; Gene Expression Regulation; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Ubiquitin | 2015 |
Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia.
Topics: Animals; Apoptosis; Binding Sites; Cells, Cultured; DNA-Binding Proteins; Endothelial Cells; Enzyme Activation; Heat Shock Transcription Factors; Homocysteine; Humans; Hyperhomocysteinemia; Lipoproteins, LDL; Methionine; Mice; Mice, Inbred C57BL; NADPH Oxidases; Phosphorylation; Protein Kinase C beta; Protein Processing, Post-Translational; Reactive Oxygen Species; RNA, Messenger; Scavenger Receptors, Class E; Sirtuin 1; Transcription Factors; Up-Regulation | 2015 |
[Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats].
Topics: Amino Acids; Animals; Beta vulgaris; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Choline Deficiency; Cysteine; Diet; Dietary Supplements; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Rats; Rats, Wistar | 2015 |
Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter.
Topics: Animals; Cells, Cultured; Cystathionine gamma-Lyase; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation; Homocysteine; Hydrogen Sulfide; Hyperhomocysteinemia; Inflammation Mediators; Macrophages; Male; Methionine; Mice; Morpholines; Organothiophosphorus Compounds; Promoter Regions, Genetic; Signal Transduction | 2015 |
High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cell Line, Tumor; Cholesterol; Diet; DNA Methylation; Fatty Acid-Binding Proteins; Foam Cells; Gene Expression Regulation; Genes, Reporter; Humans; Hyperhomocysteinemia; Male; Methionine; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Promoter Regions, Genetic; Repressor Proteins | 2015 |
Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice.
Topics: Animals; CD36 Antigens; Fatty Liver; Hepatocytes; Hyperhomocysteinemia; Lipid Metabolism; Lipoxins; Liver; Male; Methionine; Mice, Inbred C57BL; Receptors, Aryl Hydrocarbon | 2016 |
Atorvastatin attenuates atherosclerotic plaque destabilization by inhibiting endoplasmic reticulum stress in hyperhomocysteinemic mice.
Topics: Animals; Aorta; Apolipoproteins E; Atorvastatin; Blotting, Western; Down-Regulation; Endoplasmic Reticulum Stress; Homocysteine; Hyperhomocysteinemia; Macrophages; Male; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Knockout; Plaque, Atherosclerotic; RAW 264.7 Cells; Real-Time Polymerase Chain Reaction; Thapsigargin; Tumor Necrosis Factor-alpha | 2016 |
Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biotinylation; Brain; Cerebral Amyloid Angiopathy; Dementia, Vascular; Disease Models, Animal; Disease Progression; Fibrin; Fibrinogen; Fibrinolysis; Humans; Hyperhomocysteinemia; Immunohistochemistry; Maze Learning; Memory; Methionine; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Binding | 2016 |
Hepatoprotective effects of lycopene on liver enzymes involved in methionine and xenobiotic metabolism in hyperhomocysteinemic rats.
Topics: Adenosylhomocysteinase; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Biomarkers; Carotenoids; Cystathionine beta-Synthase; Diet; Homocysteine; Hyperhomocysteinemia; Liver; Liver Diseases; Lycopene; Male; Malondialdehyde; Methionine; Oxidative Stress; Rats; Rats, Wistar | 2016 |
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats.
Topics: Aneurysm, Ruptured; Animals; Arteries; Blood Pressure; Cysteine; Cytokines; Disease Models, Animal; Female; Folic Acid; Hyperhomocysteinemia; Matrix Metalloproteinase 9; Methionine; NADPH Oxidase 4; NADPH Oxidases; Ovariectomy; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Vitamin B Complex | 2016 |
Restriction of dietary methyl donors limits methionine availability and affects the partitioning of dietary methionine for creatine and phosphatidylcholine synthesis in the neonatal piglet.
Topics: Animals; Animals, Newborn; Betaine; Choline Deficiency; Creatine; Diet; Female; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Phosphatidylcholines; Protein Biosynthesis; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine; Swine, Miniature; Tritium | 2016 |
Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia.
Topics: Acetylcholinesterase; Animals; Aorta; Brain; Catalase; Cholesterol; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Endothelium, Vascular; Flavonoids; Flavonols; Glutathione; Homocysteine; Hyperhomocysteinemia; Indans; Lipid Peroxidation; Male; Maze Learning; Methionine; Necrosis; Nitric Oxide; Nitrites; Piperidines; Rats; Superoxide Dismutase | 2017 |
Involvement of histone methylation in macrophage apoptosis and unstable plaque formation in methionine-induced hyperhomocysteinemic ApoE
Topics: Animals; Apolipoproteins E; Apoptosis; Disease Models, Animal; Histones; Hyperhomocysteinemia; Methionine; Methylation; Mice; Mice, Knockout; Plaque, Atherosclerotic | 2017 |
Possible role of endothelin receptor against hyperhomocysteinemia and β-amyloid induced AD type of vascular dementia in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Bosentan; Brain; Dementia; Dementia, Vascular; Endothelins; Endothelium, Vascular; Hyperhomocysteinemia; Lipid Peroxidation; Male; Maze Learning; Memory; Methionine; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Receptors, Endothelin; Sulfonamides | 2017 |
Effect of mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats.
Topics: Animals; Blood Pressure; Collagen; Cromolyn Sodium; Drug Therapy, Combination; Hyperhomocysteinemia; Hypertrophy, Left Ventricular; Ketotifen; Male; Mast Cells; Methionine; Oxidative Stress; Rats; Rats, Wistar | 2008 |
Effects of hyperhomocysteinemia on non-adrenergic non-cholinergic relaxation in isolated rat duodenum.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Disease Models, Animal; Duodenum; Electric Stimulation; Enteric Nervous System; Enzyme Inhibitors; Epinephrine; gamma-Aminobutyric Acid; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sulfathiazoles | 2008 |
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents | 2008 |
Effects of nitric oxide modulators on cardiovascular risk factors in mild hyperhomocysteinaemic rat model.
Topics: Acyl Coenzyme A; Animals; Aorta, Thoracic; C-Reactive Protein; Cardiovascular Diseases; Caveolin 2; Disease Models, Animal; Hyperhomocysteinemia; Leukotrienes; Lipid Metabolism; Liver; Male; Methionine; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; Oxidative Stress; Rats; Rats, Wistar; Receptors, Purinergic P2; Resistin; Risk Factors | 2008 |
Effects of various amino acids on methionine-induced hyperhomocysteinemia in rats.
Topics: Amino Acids; Animals; Arginine; Dietary Supplements; Glutamic Acid; Histidine; Homocysteine; Hyperhomocysteinemia; Methionine; Rats | 2008 |
Hyperhomocysteinemia induced by guanidinoacetic acid is effectively suppressed by choline and betaine in rats.
Topics: Animals; Betaine; Choline; Dietary Supplements; Dose-Response Relationship, Drug; Glycine; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Rats | 2008 |
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation; Epilepsy; Female; Folic Acid; Humans; Hyperhomocysteinemia; Liver; Male; Methionine; Oxidation-Reduction; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Riboflavin; Valproic Acid; Vitamin B Deficiency | 2008 |
Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice.
Topics: Animals; Antioxidants; Aorta; Aryldialkylphosphatase; Biomarkers; Caffeic Acids; Cystathionine beta-Synthase; Disease Models, Animal; Female; Flavonoids; Gene Expression Regulation, Enzymologic; Heterozygote; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Phenols; Polyphenols; Receptors, Oxidized LDL; Wine | 2009 |
Effect of rosuvastatin on methionine-induced hyperhomocysteinaemia and haematological changes in rats.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Female; Fluorobenzenes; Hematologic Tests; Hemoglobins; Hyperhomocysteinemia; Hypolipidemic Agents; Leukocyte Count; Male; Methionine; Platelet Count; Pyrimidines; Rats; Rats, Wistar; Rosuvastatin Calcium; Sulfonamides; Triglycerides | 2008 |
Folate deprivation, the methionine cycle, and Alzheimer's disease.
Topics: Alzheimer Disease; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Methionine | 2008 |
Protective effect of Embelia ribes Burm on methionine-induced hyperhomocysteinemia and oxidative stress in rat brain.
Topics: Animals; Brain; Cholesterol; Embelia; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Triglycerides | 2008 |
Modulatory effect of curcumin on methionine-induced hyperlipidemia and hyperhomocysteinemia in albino rats.
Topics: Animals; Cholesterol; Curcumin; Hyperhomocysteinemia; Hyperlipidemias; Male; Methionine; Phytotherapy; Rats; Rats, Wistar; Triglycerides | 2008 |
Chronic methionine load-induced hyperhomocysteinemia impairs the relaxation induced by bradykinin in the isolated rat carotid.
Topics: Animals; Bradykinin; Cardiovascular Agents; Carotid Arteries; Chronic Disease; Enzyme Inhibitors; Hyperhomocysteinemia; Indazoles; Indomethacin; Male; Methionine; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandin Antagonists; Rats; Rats, Wistar; Receptors, Thromboxane A2, Prostaglandin H2; Vasodilator Agents; Xanthones | 2009 |
B-vitamins, homocysteine and gene polymorphism in adults with fasting or post-methionine loading hyperhomocysteinemia.
Topics: Adult; Cross-Sectional Studies; Fasting; Female; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Vitamin B Complex | 2008 |
Methionine supplementation accelerates oxidative stress and nuclear factor kappaB activation in livers of C57BL/6 mice.
Topics: Animals; Antioxidants; Cholesterol; Dietary Supplements; Enzymes; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Oxidoreductases; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Triglycerides | 2008 |
Oxidative and nitrosative stress and apoptosis in the liver of rats fed on high methionine diet: protective effect of taurine.
Topics: Alanine Transaminase; Animals; Antioxidants; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; Hyperhomocysteinemia; Inflammation; Lipid Peroxides; Liver; Male; Malondialdehyde; Methionine; Necrosis; Nitrosation; Oxidative Stress; Rats; Rats, Wistar; Taurine; Tyrosine | 2009 |
Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone.
Topics: Aged; Animals; Bone and Bones; Collagen; Female; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Male; Methionine; Myocardium; Osteoporosis; Porosity; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Stress, Mechanical | 2009 |
High-casein diet suppresses guanidinoacetic acid-induced hyperhomocysteinemia and potentiates the hypohomocysteinemic effect of serine in rats.
Topics: Animals; Caseins; Cysteine; Diet; Glycine; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Serine | 2008 |
Diet-induced hyperhomocysteinemia exacerbates vascular reverse remodeling of balloon-injured arteries in rat.
Topics: Angioplasty, Balloon; Animals; Carotid Arteries; Catheterization; Collagen; Diet; Hyperhomocysteinemia; Hyperplasia; Immunohistochemistry; Male; Methionine; Rats; Rats, Sprague-Dawley | 2008 |
Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets.
Topics: Animals; Betaine; Choline; Choline Deficiency; Cysteine; Dietary Supplements; Growth; Homocysteine; Hyperhomocysteinemia; Lipotropic Agents; Liver; Male; Methionine; Rats; Rats, Wistar | 2008 |
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.
Topics: Animals; Gene Expression Regulation; Hepatocytes; Homeostasis; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Trans-Activators; Transcription Factors; Transcription, Genetic; Transduction, Genetic | 2009 |
Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice.
Topics: Animals; Cystathionine beta-Synthase; Diet; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver; Membrane Transport Proteins; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Mice, Knockout | 2009 |
[The state of oxidant-antioxidant system in basal and latent hyperhomocysteinemia in patients with atherosclerosis of the lower extremity arteries].
Topics: Antioxidants; Atherosclerosis; Catalase; Chromatography, High Pressure Liquid; Female; Homocysteine; Humans; Hyperhomocysteinemia; Leg; Male; Malondialdehyde; Methionine; Middle Aged; Oxidative Stress; Prognosis | 2008 |
Experimental hyperhomocysteinaemia: differences in tissue metabolites between homocystine and methionine feeding in a rat model.
Topics: Analysis of Variance; Animal Feed; Animals; Cardiovascular Diseases; Dietary Supplements; Disease Models, Animal; Female; Homocystine; Hyperhomocysteinemia; Kidney; Liver; Methionine; Methylation; Rats; Rats, Wistar; S-Adenosylmethionine; Statistics, Nonparametric; Tissue Distribution | 2009 |
Methionine-induced hyperhomocysteinemia modulates lipoprotein profile and oxidative stress but not progression of atherosclerosis in aged apolipoprotein E knockout mice.
Topics: Alanine Transaminase; Animals; Antioxidants; Apolipoproteins E; Aspartate Aminotransferases; Atherosclerosis; Cholesterol; Folic Acid; Glutathione; Hyperhomocysteinemia; Lipoproteins; Male; Methionine; Mice; Mice, Knockout; NF-kappa B; Oxidative Stress; RNA, Messenger | 2009 |
High casein diet decreases plasma homocysteine concentration in rats.
Topics: Amino Acids; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Caseins; Cystathionine beta-Synthase; Diet; Dose-Response Relationship, Drug; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Serine | 2009 |
Hypohomocysteinemic effect of cysteine is associated with increased plasma cysteine concentration in rats fed diets low in protein and methionine levels.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Caseins; Choline; Cystathionine beta-Synthase; Cysteic Acid; Cysteine; Diet, Protein-Restricted; Dietary Supplements; Glycine; Homocysteine; Hyperhomocysteinemia; Male; Mercaptoethylamines; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; Soybean Proteins | 2009 |
Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats.
Topics: Animals; Cardiovascular Agents; Cysteine; Dose-Response Relationship, Drug; Glutathione; Homocysteine; Hyperhomocysteinemia; Lactates; Male; Methionine; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza | 2009 |
Raloxifene ameliorates detrimental enzymatic and nonenzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia.
Topics: Animals; Arginine; Bone and Bones; Bone Density; Bone Density Conservation Agents; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycation End Products, Advanced; Hyperhomocysteinemia; Lysine; Methionine; Osteoporosis; Rabbits; Raloxifene Hydrochloride; Stress, Mechanical | 2010 |
Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cardiotonic Agents; Creatine Kinase, MB Form; Female; Glutathione; Heart; Heart Ventricles; Hyperhomocysteinemia; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Lactate Dehydrogenases; Male; Methionine; Myocardial Infarction; Myocardial Reperfusion Injury; Oxidative Stress; Rats; Rats, Wistar; Severity of Illness Index; Thiobarbituric Acid Reactive Substances | 2009 |
Sacroiliitis and muscle cramps in a healthy young man: some spearhead on MTHFR mutations.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Biomarkers; DNA Mutational Analysis; Gene Expression Regulation, Enzymologic; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Keratolytic Agents; Low Back Pain; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Cramp; Muscle, Skeletal; Mutation; Radiography; Sacroiliac Joint; Sulfasalazine; Tretinoin | 2010 |
Hydrogen sulfide attenuates hyperhomocysteinemia-induced cardiomyocytic endoplasmic reticulum stress in rats.
Topics: Animals; Caspase 12; Endoplasmic Reticulum; Heat-Shock Proteins; Hydrogen Sulfide; Hyperhomocysteinemia; Male; Methionine; Microscopy, Electron, Transmission; Myocytes, Cardiac; Rats; Rats, Wistar; Thapsigargin; Transcription Factor CHOP; Tunicamycin | 2010 |
Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis.
Topics: Animals; Annexin A2; Cell Movement; Corneal Neovascularization; Diet; Endothelial Cells; Fibrin; Fibrinolysis; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Recombinant Proteins | 2009 |
Possible involvement of PKC-delta in the abrogated cardioprotective potential of ischemic preconditioning in hyperhomocysteinemic rat hearts.
Topics: Acetophenones; Animals; Benzopyrans; Enzyme Activation; Female; Hyperhomocysteinemia; Ischemic Preconditioning, Myocardial; Lipid Peroxidation; Male; Methionine; Myocardial Infarction; Oxidative Stress; Protein Kinase C-delta; Protein Kinase Inhibitors; Rats; Rats, Wistar; Reperfusion Injury; Superoxides | 2010 |
The nutrigenetics of hyperhomocysteinemia: quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia.
Topics: Adenosylhomocysteinase; Animals; Antioxidants; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Diet; Glycine N-Methyltransferase; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nutrigenomics; Peroxiredoxins; Proteomics; Urea | 2010 |
Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia.
Topics: Acyl Coenzyme A; Animals; Cholesterol Esters; CpG Islands; Cystathionine beta-Synthase; Diet; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Lipid Metabolism; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Oleic Acid; RNA, Messenger; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2 | 2010 |
Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.
Topics: Acetylcholine; Amidohydrolases; Animals; Arginine; Arterioles; Carotid Artery Thrombosis; Cerebral Arterial Diseases; Diet; Folic Acid Deficiency; Humans; Hyperhomocysteinemia; Hypertrophy; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Papaverine; Vasodilation; Vasodilator Agents | 2010 |
Chronic pancreatitis is associated with hyperhomocysteinemia and derangements in transsulfuration and transmethylation pathways.
Topics: Adult; Creatinine; Cysteine; Erythrocytes; Female; Folic Acid; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Middle Aged; Models, Biological; Multivariate Analysis; Pancreatitis, Alcoholic; Pancreatitis, Chronic; Regression Analysis; Signal Transduction; Sulfates; Sulfur; Young Adult | 2010 |
Effects of maternal hyperhomocysteinemia induced by methionine intake on oxidative stress and apoptosis in pup rat brain.
Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Brain; DNA Fragmentation; Female; Hyperhomocysteinemia; Lipid Peroxidation; Maternal-Fetal Exchange; Methionine; Oxidative Stress; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2010 |
Ameliorative role of rosiglitazone in hyperhomocysteinemia-induced experimental cardiac hypertrophy.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Homocysteine; Hyperhomocysteinemia; Hypertrophy, Left Ventricular; Male; Methionine; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar; Rosiglitazone; Thiazolidinediones | 2010 |
Acute hyperhomocysteinaemia blunts endothelial dependent and endothelial independent vasodilatation in diabetic patients.
Topics: Acetylcholine; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Greece; Humans; Hyperhomocysteinemia; Laser-Doppler Flowmetry; Male; Methionine; Microcirculation; Middle Aged; Nitroprusside; Skin; Time Factors; Vasodilation; Vasodilator Agents | 2010 |
Severe In vivo hyper-homocysteinemia is not associatedwith elevation of amyloid-beta peptides in the Tg2576 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Humans; Hyperhomocysteinemia; Methionine; Mice; Mice, Transgenic; Peptide Fragments; Random Allocation; Vitamin B 12 | 2010 |
Evaluation of mild hyperhomocysteinemia during the development of atherosclerosis in apolipoprotein E-deficient and normal mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Diet; Endoplasmic Reticulum; Folic Acid; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Time Factors | 2011 |
Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Cell Culture Techniques; Cell Line; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vasodilation | 2010 |
The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Humans; Hyperhomocysteinemia; Methionine; Pregnancy; Pyridoxal Phosphate; Reproducibility of Results; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2011 |
Frequency of afterload homocysteinemia in normal population of Southern Iran: a pilot study.
Topics: Adult; Female; Homocysteine; Humans; Hyperhomocysteinemia; Iran; Male; Methionine; Pilot Projects; Young Adult | 2010 |
Hepatocyte proliferation during liver regeneration is impaired in mice with methionine diet-induced hyperhomocysteinemia.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Diet; Hepatectomy; Hepatocytes; Humans; Hyperhomocysteinemia; Liver; Liver Regeneration; Methionine; Mice; Mice, Inbred BALB C; Phosphorylation; Proto-Oncogene Proteins c-akt; Tumor Suppressor Protein p53 | 2010 |
Danshensu protects vascular endothelia in a rat model of hyperhomocysteinemia.
Topics: Animals; Aorta, Thoracic; Atherosclerosis; Cardiovascular Agents; Diet; Disease Models, Animal; Endothelins; Endothelium, Vascular; Female; Hyperhomocysteinemia; Intercellular Adhesion Molecule-1; Lactates; Male; Methionine; Nitric Oxide; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2010 |
Folic acid supplementation inhibits NADPH oxidase-mediated superoxide anion production in the kidney.
Topics: Acetophenones; Animals; Cells, Cultured; Folic Acid; Humans; Hyperhomocysteinemia; Kidney; Male; Methionine; NADPH Oxidases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxides; Xanthine Oxidase | 2011 |
[Promoting effect of hyperhomocysteinemia on vascular calcification in rats].
Topics: Alkaline Phosphatase; Animals; Calcium; Endothelium, Vascular; Hyperhomocysteinemia; Lipid Peroxidation; Male; Methionine; Osteocalcin; Rats; Rats, Sprague-Dawley; Vascular Calcification | 2004 |
Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice.
Topics: Animals; Cystathionine beta-Synthase; Hyperhomocysteinemia; Liver Cirrhosis; Matrix Metalloproteinase 2; Methionine; Mice; Mice, Transgenic; Polyphenols; Wine | 2011 |
Phytoestrogen α-zearalanol improves vascular function in ovariectomized hyperhomocysteinemic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelin-1; Estradiol; Female; Homocysteine; Hyperhomocysteinemia; Methionine; Nitric Oxide Synthase Type III; Nitroprusside; Ovariectomy; Phenylephrine; Phytoestrogens; Rats; Rats, Wistar; Zeranol | 2011 |
Methionine diet-induced hyperhomocysteinemia accelerates cerebral aneurysm formation in rats.
Topics: Animals; Diet; Endothelium, Vascular; Hyperhomocysteinemia; Inflammation; Intracranial Aneurysm; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methionine; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2011 |
Ameliorative role of atorvastatin on methionine-induced hyperhomocysteinemia and hematological changes in albino rats.
Topics: Albinism; Animals; Anticholesteremic Agents; Atorvastatin; Drug Evaluation, Preclinical; Female; Hematologic Tests; Heptanoic Acids; Hyperhomocysteinemia; Male; Methionine; Pyrroles; Rats; Rats, Mutant Strains; Rats, Wistar | 2011 |
Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3.
Topics: Animals; Cell Cycle Proteins; Disease Progression; Glycogen; Homocysteine; Humans; Hyperhomocysteinemia; Indoles; Insulin Resistance; Liver Glycogen; Methionine; Mice; Phosphorylation; PPAR gamma; Protein Serine-Threonine Kinases; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering | 2011 |
Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins.
Topics: Adult; Antioxidants; Arginine; Ascorbic Acid; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Male; Methionine; Middle Aged; Vasodilation; Vitamin E | 2011 |
Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain.
Topics: Animals; Brain; Female; Folic Acid; Frontal Lobe; Homocysteine; Homocystine; Hyperhomocysteinemia; Methionine; Methylation; Neurofilament Proteins; Phosphoproteins; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Wistar; tau Proteins | 2011 |
Hyperhomocysteinemia inhibited cardiac stem cell homing into the peri-infarcted area post myocardial infarction in rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Movement; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Male; Methionine; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stem Cell Factor; Stem Cells | 2011 |
Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis.
Topics: Adult; Age of Onset; Analysis of Variance; Biomarkers; Case-Control Studies; Chi-Square Distribution; Cystathionine beta-Synthase; Dinoprost; Female; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Italy; Linear Models; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidative Stress; Phenotype; Platelet Activation; Platelet Function Tests; Thrombosis; Thromboxane B2; Time Factors | 2011 |
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity.
Topics: Animals; Betaine-Homocysteine S-Methyltransferase; Cystathionine beta-Synthase; Cysteine; Diet; Enzyme Inhibitors; Fatty Liver; Glutathione; Homeostasis; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 2011 |
[Effects of training on plasma content of nitric oxide, endothelin and NO/ET system in rats fed with high methionine diet].
Topics: Animals; Dietary Supplements; Endothelins; Hyperhomocysteinemia; Male; Methionine; Nitric Oxide; Nitric Oxide Synthase; Physical Conditioning, Animal; Rats; Rats, Wistar; Swimming | 2011 |
Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration.
Topics: Animals; Biomarkers; Brain; Folic Acid Deficiency; Formates; Homocysteine; Hyperhomocysteinemia; Liver; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methionine; Methylation; Methylmalonic Acid; Models, Biological; Random Allocation; Rats; Rats, Sprague-Dawley; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2012 |
Gingko biloba extract inhibits oxidative stress and ameliorates impaired glial fibrillary acidic protein expression, but can not improve spatial learning in offspring from hyperhomocysteinemic rat dams.
Topics: Animals; Behavior, Animal; Brain; Female; Ginkgo biloba; Glial Fibrillary Acidic Protein; Hyperhomocysteinemia; Lipid Peroxidation; Male; Maze Learning; Memory; Methionine; Mitochondria; Oxidative Stress; Plant Extracts; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 2012 |
Methionine and serine synergistically suppress hyperhomocysteinemia induced by choline deficiency, but not by guanidinoacetic acid, in rats fed a low casein diet.
Topics: Animals; Caseins; Choline; Diet; Dietary Supplements; Drug Synergism; Glycine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Serine | 2011 |
Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
Topics: Amination; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Chromatography, Liquid; Cystathionine gamma-Lyase; Diet; Disease Models, Animal; Electrophoresis, Capillary; Hyperhomocysteinemia; Mass Spectrometry; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction | 2012 |
Salutary effect of NFκB inhibitor and folacin in hyperhomocysteinemia-hyperlipidemia induced vascular dementia.
Topics: Acetylcholinesterase; Animals; Dementia, Vascular; Ditiocarb; Endothelium, Vascular; Folic Acid; Hyperhomocysteinemia; Hyperlipidemias; Male; Maze Learning; Methionine; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia.
Topics: Animals; Annexin A2; Blood Coagulation; Bone Marrow Transplantation; Disease Models, Animal; Fibrinolysin; Fibrinolysis; Homocysteine; Hyperhomocysteinemia; Leukemia, Promyelocytic, Acute; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Recombinant Proteins; Tissue Plasminogen Activator | 2012 |
Coagulopathy in APL: a step forward?
Topics: Animals; Annexin A2; Fibrinolysis; Hyperhomocysteinemia; Leukemia, Promyelocytic, Acute; Methionine | 2012 |
Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism.
Topics: Biomarkers; Cardiovascular Diseases; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Dinoprost; Dyslipidemias; Folic Acid; Homocystinuria; Humans; Hyperhomocysteinemia; Lipid Peroxidation; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Oxidative Stress; Platelet Activation; Polymorphism, Single Nucleotide; Psychotic Disorders; Smoking; Thromboxane B2 | 2012 |
Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats.
Topics: Animals; Caseins; Choline; Choline Deficiency; Diet; Glycine; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Serine | 2012 |
A model of hyperhomocysteine-induced endothelial dysfunction in rats.
Topics: Animals; Endothelium, Vascular; Hyperhomocysteinemia; Methionine; Rats; Vascular Diseases | 2011 |
Dietary folic acid intake differentially affects methionine metabolism markers and hippocampus morphology in aged rats.
Topics: Aging; Animals; Astrocytes; Biomarkers; Cognitive Dysfunction; Diet; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Hippocampus; Hyperhomocysteinemia; Male; Methionine; Methylation; Neurons; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine | 2013 |
Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aorta; Atherosclerosis; Biomarkers; Catechin; Crosses, Genetic; Cystathionine beta-Synthase; Cytokines; Dietary Supplements; Down-Regulation; Endothelium, Vascular; Female; Hyperhomocysteinemia; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Stereoisomerism | 2013 |
Does phase angle correlate with hyperhomocysteinemia? A study of patients with classical homocystinuria.
Topics: Adolescent; Adult; Cysteine; Female; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Life Expectancy; Male; Methionine; Prognosis; Young Adult | 2013 |
The comprehensive effects of hyperlipidemia and hyperhomocysteinemia on pathogenesis of atherosclerosis and DNA hypomethylation in ApoE-/- mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholesterol; Cholesterol, Dietary; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Gene Expression; Homocysteine; Hyperhomocysteinemia; Hyperlipidemias; Lipids; Male; Methionine; Mice; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; S-Adenosylhomocysteine; S-Adenosylmethionine; Triglycerides | 2012 |
Folic acid fortification ameliorates hyperhomocysteinemia caused by a vitamin B₆-deficient diet supplemented with L-methionine.
Topics: Animals; Body Weight; Dietary Supplements; Eating; Folic Acid; Hyperhomocysteinemia; Male; Methionine; Pilot Projects; Rats; Rats, Wistar; Vitamin B 6 Deficiency | 2012 |
Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet.
Topics: Administration, Oral; Animals; Catalase; Cycas; Diet; Dietary Supplements; Folic Acid; Glutathione Peroxidase; Heart; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Plant Extracts; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tocotrienols | 2013 |
Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation.
Topics: Animals; Brain; Cerebral Hemorrhage; Dementia, Vascular; Diet; Disease Models, Animal; Folic Acid; Humans; Hyperhomocysteinemia; Inflammation; Interleukin-1beta; Interleukin-6; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Memory Disorders; Methionine; Mice; Mice, Inbred C57BL; Vitamin B 12; Vitamin B 6 | 2013 |
Involvement of 5-methyltetrahydrofolate in the amelioration of hyperhomocysteinemia caused by vitamin B(6) deficiency and L-methionine supplementation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Dietary Supplements; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Tetrahydrofolates; Vitamin B 6; Vitamin B 6 Deficiency | 2013 |
[The abnormal reaction to post methionine loading test in type diabetes with or without retinopathy].
Topics: Aged; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Nitrates; Oxidoreductases Acting on CH-NH Group Donors; Time Factors | 2002 |
Effect of hyperhomocysteinemia on protein C activation and activity.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; Enzyme Activation; Factor V; Female; Haplorhini; Humans; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Inbred C57BL; Partial Thromboplastin Time; Protein C; Thrombin | 2002 |
Vascular responses in male and female hypertensive rats with hyperhomocysteinemia.
Topics: Animals; Blood Pressure; Culture Techniques; Endothelium, Vascular; Estradiol; Female; Homocysteine; Hyperhomocysteinemia; Hypertension; Male; Methionine; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Sex Factors; Vasoconstriction; Vasodilation | 2002 |
Folic acid and vitamin B(12) supplementation attenuates isoprenaline-induced myocardial infarction in experimental hyperhomocysteinemic rats.
Topics: Animals; Blood Pressure; Creatine Kinase; Folic Acid; Glutathione; Heart Rate; Hemodynamics; Hyperhomocysteinemia; Isoproterenol; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Malondialdehyde; Methionine; Myocardial Infarction; Myocardium; Oxidative Stress; Rats; Rats, Wistar; Vitamin B 12 | 2002 |
Renal tubulointerstitial injury in weanling rats with hyperhomocysteinemia.
Topics: Age Factors; Animal Feed; Animals; Choline; Folic Acid; Homocysteine; Hyperhomocysteinemia; Methionine; Nephritis, Interstitial; Rats; Rats, Inbred F344; Weaning | 2002 |
Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice.
Topics: Animals; Arterioles; Basement Membrane; Blood Pressure; Brain; Collagen; Cystathionine beta-Synthase; Diet; Disease Models, Animal; Elastin; Genotype; Heterozygote; Hyperhomocysteinemia; Hypertrophy; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Vascular Patency | 2002 |
Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction.
Topics: Animals; Aorta, Thoracic; Carotid Arteries; Catalase; Diet; Endothelium, Vascular; Ethidium; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Superoxide Dismutase; Superoxides; Vasomotor System | 2002 |
The effect of folic acid, vitamin B6 and vitamin B12 on the homocysteine levels in rabbits fed by methionine-enriched diets.
Topics: Animals; Diet; Dose-Response Relationship, Drug; Drug Combinations; Female; Folic Acid; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rabbits; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 6 | 2002 |
Hyperhomocysteinemia: could the post-methionine oral loading test sometimes be avoided?
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Sensitivity and Specificity; Thrombosis | 2003 |
Effect of a methionine-supplemented diet on the blood pressure of Wistar-Kyoto and spontaneously hypertensive rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta; Bradykinin; Cysteine; Dietary Supplements; Endothelium, Vascular; Glutathione; Homocysteine; Hyperhomocysteinemia; Hypertension; Male; Methionine; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium; Systole; Vasodilator Agents | 2003 |
Low diagnostic value of fasting and post-methionine load homocysteine tests. A study in Dutch subjects with homocysteine test indications.
Topics: Adult; Cardiovascular Diseases; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Netherlands; Prevalence; Reference Values; Retrospective Studies; Risk Factors; Sensitivity and Specificity | 2003 |
Changes in markers of vascular injury in response to transient hyperhomocysteinemia.
Topics: Adult; Animals; Biomarkers; Blood Vessels; Enzyme-Linked Immunosorbent Assay; Female; Fibronectins; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Transgenic; Vascular Cell Adhesion Molecule-1 | 2003 |
Hyperhomocysteinemia in cerebral vein thrombosis.
Topics: Adolescent; Adult; Case-Control Studies; Child; Female; Folic Acid; Homocystine; Humans; Hyperhomocysteinemia; Intracranial Thrombosis; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Risk Factors; Thrombophilia; Venous Thrombosis; Vitamin B 12 | 2003 |
Methionine metabolism in liver diseases.
Topics: Humans; Hyperhomocysteinemia; Liver; Liver Diseases; Methionine; S-Adenosylmethionine | 2003 |
Determinants of hyperhomocysteinemia in patients with chronic liver disease and after orthotopic liver transplantation.
Topics: Adult; Area Under Curve; Case-Control Studies; Chronic Disease; Creatinine; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Diseases; Liver Transplantation; Male; Metabolic Clearance Rate; Methionine; Middle Aged; Vitamin B 12; Vitamin B 6 | 2003 |
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice.
Topics: Animals; Betaine; Central Nervous System Depressants; Disease Models, Animal; Endoplasmic Reticulum; Ethanol; Fatty Liver, Alcoholic; Gastrointestinal Agents; Gene Expression; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis | 2003 |
Infantile hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trap.
Topics: Brain Edema; Female; Food, Fortified; Humans; Hyperhomocysteinemia; Infant; Infant Food; Infant Nutritional Physiological Phenomena; Infant, Newborn; Magnetic Resonance Imaging; Male; Methionine | 2003 |
Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Brachiocephalic Trunk; Diet; Dietary Supplements; Female; Homocysteine; Hyperhomocysteinemia; Lipids; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Vitamins | 2003 |
Adverse effect of nitrous oxide in a child with 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Anesthetics, Inhalation; Cells, Cultured; DNA Mutational Analysis; Fatal Outcome; Fibroblasts; Folic Acid; Genes, Recessive; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Infant; Male; Metabolism, Inborn Errors; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Nitrous Oxide; Oxidoreductases; Point Mutation; Polymorphism, Genetic; RNA | 2003 |
Patients with systemic lupus erythematosus show increased platelet activation and endothelial dysfunction induced by acute hyperhomocysteinemia.
Topics: Acute Disease; Administration, Oral; Adult; Brachial Artery; Endothelium, Vascular; Female; Flow Cytometry; Humans; Hyperhomocysteinemia; Lupus Erythematosus, Systemic; Male; Methionine; Plasminogen Activator Inhibitor 1; Platelet Activation; Regional Blood Flow; Vasodilation; von Willebrand Factor | 2003 |
Genetic determinants of fasting and post-methionine hyperhomocysteinemia in patients with retinal vein occlusion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Cystathionine beta-Synthase; Fasting; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutagenesis, Insertional; Mutation, Missense; Point Mutation; Polymorphism, Genetic; Retinal Vein Occlusion; Risk Factors; Thrombophilia | 2003 |
HOMOCYSTINURIA. BIOCHEMICAL STUDIES OF TISSUES INCLUDING A COMPARISON WITH CYSTATHIONINURIA.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Brain; Brain Chemistry; Chemistry Techniques, Analytical; Cystathionine gamma-Lyase; Geriatrics; Homocysteine; Homocystinuria; Humans; Hydro-Lyases; Hyperhomocysteinemia; Methionine; Oxidoreductases; Transferases; Urine | 1965 |
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
Topics: Animals; Aorta; Arterioles; Cerebral Arteries; Choline; Crosses, Genetic; Cysteine; Diet; Endothelium, Vascular; Genotype; Hyperhomocysteinemia; In Vitro Techniques; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred BALB C; Mice, Knockout; Muscle, Smooth, Vascular; Vitamin B Complex | 2004 |
The atherogenic effect of excess methionine intake.
Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Diet; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Models, Biological; Vitamin B 12; Vitamin B 6; Vitamin B Deficiency | 2003 |
Changes in pulmonary vascular function after acute methionine loading in normal men.
Topics: Adult; Biomarkers; Breath Tests; Endothelium, Vascular; Exercise Test; Factor VIII; Humans; Hyperhomocysteinemia; Male; Methionine; Nitric Oxide; Pulmonary Circulation; Pulmonary Gas Exchange; von Willebrand Factor | 2004 |
Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats.
Topics: Analysis of Variance; Animals; Benzoquinones; Hyperhomocysteinemia; Male; Methionine; Nigella sativa; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Seeds | 2004 |
Plasma homocysteine after insulin infusion in type II diabetic patients with and without methionine intolerance.
Topics: Blood Glucose; Cysteine; Diabetes Mellitus, Type 2; DNA; Female; Folic Acid; Glucose Clamp Technique; Homocysteine; Humans; Hyperhomocysteinemia; Insulin; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Point Mutation; Polymerase Chain Reaction; Vitamin B 12; Vitamin B 6 | 2004 |
Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Biological Availability; Catalase; Copper; Cysteine; Diet; Dietary Supplements; Glutathione; Homocysteine; Hyperhomocysteinemia; Hypertension; Iron; Liver; Male; Methionine; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2004 |
Chinese yam (Dioscorea alata cv. Tainung No. 2) feeding exhibited antioxidative effects in hyperhomocysteinemia rats.
Topics: Animals; Antioxidants; Diet; Dioscorea; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Male; Methionine; Oxidative Stress; Platelet Aggregation; Rats; Rats, Sprague-Dawley | 2004 |
Mild hyperhomocysteinemia induced by feeding rats diets rich in methionine or deficient in folate promotes early atherosclerotic inflammatory processes.
Topics: Animals; Aorta; Arteriosclerosis; Chemokine CCL2; Diet; Endothelium, Vascular; Folic Acid; Folic Acid Deficiency; Hyperhomocysteinemia; Inflammation; Intercellular Adhesion Molecule-1; Male; Malondialdehyde; Methionine; NF-kappa B; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2004 |
Hyperhomocysteinemia activates NF-kappaB and inducible nitric oxide synthase in the kidney.
Topics: Animals; Diet; Hyperhomocysteinemia; Kidney; Male; Methionine; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proline; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiocarbamates; Tyrosine | 2004 |
Endothelial cell adhesion molecules in healthy adults during acute hyperhomocysteinemia and mild hypertriglyceridemia.
Topics: Acute Disease; Administration, Oral; Adult; Cardiovascular Diseases; Cell Adhesion Molecules; Comorbidity; Dietary Fats; Drug Synergism; Endothelium; Female; Homocysteine; Humans; Hyperhomocysteinemia; Hypertriglyceridemia; Inflammation; Male; Methionine; Middle Aged; P-Selectin; Risk Factors; Triglycerides | 2004 |
Endothelium-derived hyperpolarizing factor-mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia.
Topics: Acetylcholine; Acute Disease; Adenosine; Animals; Biological Factors; Chronic Disease; Cyclooxygenase Inhibitors; Endothelium, Vascular; Female; Hyperhomocysteinemia; Indomethacin; Methionine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitroso Compounds; Oxidation-Reduction; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Renal Circulation; Vasodilation; Vitamin B Complex; Vitamin B Deficiency | 2004 |
Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency.
Topics: Animal Feed; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Cystathionine beta-Synthase; Cysteine; Female; Heterozygote; Homocysteine; Hyperhomocysteinemia; Lipotropic Agents; Liver; Male; Methionine; Methyltransferases; Mice; Mice, Inbred C57BL; Regression Analysis; Serine | 2004 |
Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcholine; Animals; Arterioles; Cerebrovascular Disorders; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Hyperhomocysteinemia; Methionine; Mice; Nitroprusside; Oxidative Stress; Superoxides; Vasodilation; Vasodilator Agents | 2004 |
Hyperhomocysteinemia, pregnancy complications, and the timing of investigation.
Topics: Adult; Case-Control Studies; Female; Fetal Growth Retardation; HELLP Syndrome; Humans; Hyperhomocysteinemia; Maternal Age; Methionine; Netherlands; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Outcome; Prenatal Care; Prenatal Diagnosis; Risk Factors | 2004 |
Methionine-induced hyperhomocysteinemia promotes superoxide anion generation and NFkappaB activation in peritoneal macrophages of C57BL/6 mice.
Topics: Animals; Anions; Cells, Cultured; Diet; Hyperhomocysteinemia; Kinetics; Macrophages, Peritoneal; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Superoxides | 2004 |
High dietary methionine plus cholesterol exacerbates atherosclerosis formation in the left main coronary artery of rabbits.
Topics: Animal Feed; Animals; Arterioles; Cholesterol, Dietary; Coronary Artery Disease; Coronary Vessels; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rabbits; Risk Factors; Tunica Intima; Tunica Media | 2004 |
[The mechanism of homocysteine in Kkay mice diabetic nephropathy model].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Homocystine; Hyperhomocysteinemia; Male; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; RNA, Messenger | 2004 |
Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats.
Topics: Animals; Betaine; Disease Models, Animal; Glycine; Homocysteine; Hyperhomocysteinemia; Injections, Intravenous; Male; Methionine; Rats; Sarcosine | 2004 |
Effect of folic acid on methionine and homocysteine metabolism in end-stage renal disease.
Topics: Administration, Oral; Adult; Aged; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Kinetics; Male; Methionine; Methylation; Middle Aged; Renal Dialysis | 2005 |
Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults.
Topics: Acute Disease; Animals; Arginine; Biological Availability; Enzyme Inhibitors; Haplorhini; Humans; Hyperhomocysteinemia; Methionine; Nitric Oxide; Oxidative Stress; Reproducibility of Results | 2005 |
Hyperhomocysteinemia, a cardiac metabolic disease: role of nitric oxide and the p22phox subunit of NADPH oxidase.
Topics: Animals; Heart Diseases; Hyperhomocysteinemia; Male; Membrane Transport Proteins; Methionine; Mice; Mice, Knockout; Myocardium; NADPH Oxidases; Nitric Oxide; Oxygen Consumption; Phosphoproteins; Rats; Rats, Wistar; Superoxides; Up-Regulation | 2005 |
von Willebrand factor multimer composition is modified following oral methionine load in women with thrombosis, but not in healthy women.
Topics: Adult; Case-Control Studies; Dimerization; Female; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Middle Aged; Peptide Fragments; Peptide Hydrolases; Thrombosis; von Willebrand Factor | 2005 |
Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Disease Models, Animal; Glutathione; Hippocampus; Hyperhomocysteinemia; Learning Disabilities; Lipid Peroxidation; Male; Maze Learning; Melatonin; Memory Disorders; Methionine; Neural Cell Adhesion Molecules; Rats; Rats, Wistar | 2005 |
Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholics.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alcoholism; Avitaminosis; Comorbidity; Cystathionine beta-Synthase; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Male; Methionine; Methylation; Middle Aged; Prevalence | 2005 |
Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate.
Topics: Acetylcholine; Animals; Diet; Endothelium, Vascular; Folic Acid Deficiency; Hyperhomocysteinemia; Male; Methionine; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Oxygen; Rats; Vasodilation | 2006 |
[Folate reduces monocyte chemoattractant protein-1 expression in rats with hyperhomocysteinemia].
Topics: Animals; Aorta; Chemokine CCL2; Endothelium, Vascular; Folic Acid; Homocysteine; Hyperhomocysteinemia; Leukocytes, Mononuclear; Male; Methionine; Random Allocation; Rats; Rats, Sprague-Dawley | 2005 |
Melatonin prevents hyperhomocysteinemia and neural lipid peroxidation induced by methionine intake.
Topics: Animals; Antioxidants; Brain; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; Methionine; Oxidative Stress; Rats; Rats, Wistar | 2005 |
Homocysteine and coronary microcirculation: is it a microvasculopathic agent?
Topics: Administration, Oral; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Coronary Circulation; Coronary Disease; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Methionine | 2006 |
Moderate hyperhomocysteinemia and early-onset central retinal vein occlusion.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxal Phosphate; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2006 |
Methionine adenosyltransferase (MAT) I/III deficiency with concurrent hyperhomocysteinaemia: two novel cases.
Topics: Adult; Child, Preschool; Diagnosis, Differential; Female; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Male; Metabolism, Inborn Errors; Methionine; Methionine Adenosyltransferase; Mutation; Mutation, Missense | 2005 |
Inhibition of protein tyrosin phosphatase improves vascular endothelial dysfunction.
Topics: Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hyperhomocysteinemia; Male; Methionine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Potassium Channels; Protein Tyrosine Phosphatases; Pyrones; Rats; Rats, Sprague-Dawley; Streptozocin; Thiobarbituric Acid Reactive Substances; Vanadates; Vasodilation | 2006 |
Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation and superoxide formation in the aorta of the rabbit.
Topics: Acetophenones; Acetylcholine; Administration, Oral; Animals; Aorta; Blotting, Western; Cyclic GMP; Dietary Supplements; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Methionine; NADPH Oxidases; Nitric Oxide Donors; Nitroprusside; Onium Compounds; Penicillamine; Rabbits; Superoxides; Time Factors; Vasodilation; Vasodilator Agents | 2006 |
Proton MR spectroscopy in hyperhomocysteinemia with elevated blood methionine levels.
Topics: Brain; Child; Female; Humans; Hyperhomocysteinemia; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methionine | 2006 |
No added value of the methionine loading task in assessment for venous thrombosis and cardiovascular disease risk.
Topics: Aged; Cardiovascular Diseases; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Practice Guidelines as Topic; Risk; ROC Curve; Venous Thrombosis | 2006 |
Pathophysiological consequences of homocysteine excess.
Topics: Autoantibodies; Blood Proteins; Cell Death; Diet; Endoplasmic Reticulum; Homocysteine; Humans; Hyperhomocysteinemia; Lysine; Methionine; Protein Binding | 2006 |
Changes in atrium and thoracic aorta reactivity to adenosinergic and adrenergic agonists in experimental hyperhomocysteinemia.
Topics: Adenosine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Aorta, Thoracic; Blood Pressure; Dipyridamole; Heart Atria; Heart Rate; Homocysteine; Hyperhomocysteinemia; Isoproterenol; Male; Methionine; Phenylephrine; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Theophylline; Vasoconstriction; Vasodilation | 2006 |
Hyperhomocysteinemia increases arterial permeability and stiffness in mice.
Topics: Animals; Arteries; Atherosclerosis; Capillary Permeability; Elasticity; Endothelium, Vascular; Homocysteine; Hyperhomocysteinemia; Lipoproteins; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide; Superoxides; Vascular Resistance | 2006 |
Body composition: an important determinant of homocysteine and methionine concentrations in healthy individuals.
Topics: Adipose Tissue; Adult; Body Composition; Body Water; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Life Style; Male; Menopause; Methionine; Middle Aged; Muscle, Skeletal; Risk Factors; Sex Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation in the corpus cavernosum in the rabbit.
Topics: Animals; Chelating Agents; Dietary Supplements; Dose-Response Relationship, Drug; Endothelium, Vascular; Hyperhomocysteinemia; Male; Methionine; Muscle Relaxation; Penicillamine; Penis; Rabbits | 2006 |
Suppression of methionine-induced hyperhomocysteinemia by dietary eritadenine in rats.
Topics: Adenine; Animals; Cystathionine beta-Synthase; Diet; Dose-Response Relationship, Drug; Enzyme Activation; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 2006 |
The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice.
Topics: Animals; Apolipoproteins E; Behavior, Animal; Brain; Cognition Disorders; Disease Models, Animal; Folic Acid Deficiency; Hyperhomocysteinemia; Male; Maze Learning; Methionine; Mice; Neuropsychological Tests; Nutrition Disorders; Psychomotor Performance; Severity of Illness Index; Space Perception; Vitamin B 12 Deficiency | 2006 |
Diet-induced hyperhomocysteinemia does not lead to large gene-expression differences in rat aorta.
Topics: Animals; Aorta; Diet; Disease Models, Animal; Female; Gene Expression; Gene Expression Profiling; Hyperhomocysteinemia; Methionine; Microarray Analysis; Oxidative Stress; Rats; Rats, Wistar; Vascular Diseases | 2007 |
Low fasting methionine concentration as a novel risk factor for recurrent venous thrombosis.
Topics: Adult; Aged; Case-Control Studies; Cysteine; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Middle Aged; Multivariate Analysis; Odds Ratio; Recurrence; Risk Assessment; Risk Factors; Venous Thrombosis | 2006 |
Methionine challenge paradoxically induces a greater activation of the antioxidant defence in subjects with hyper- vs. normohomocysteinemia.
Topics: Adult; Antioxidants; Female; Glutathione; Humans; Hyperhomocysteinemia; Male; Malondialdehyde; Methionine; Middle Aged; Oxidation-Reduction; Oxidative Stress; Sulfhydryl Compounds; Vitamins | 2006 |
Suppression of methionine-induced hyperhomocysteinemia by glycine and serine in rats.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Glycine; Hyperhomocysteinemia; Liver; Methionine; Rats; Serine | 2006 |
Plasma cysteine and glutathione are independent markers of postmethionine load endothelial dysfunction.
Topics: Adult; Biomarkers; Brachial Artery; Cardiovascular Diseases; Cysteine; Endothelium, Vascular; Glutathione; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Oxidation-Reduction; Oxidative Stress; Prognosis; Regional Blood Flow; Ultrasonography; Vasodilation | 2007 |
Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice.
Topics: Animals; Apolipoproteins E; Body Weight; Cholesterol; Disease Susceptibility; Endothelium, Vascular; Gene Expression Regulation; Homocysteine; Hypercholesterolemia; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Knockout; Platelet Activation; Thrombosis | 2007 |
Ginseng saponins diminish adverse vascular effects associated with chronic methionine-induced hyperhomocysteinemia.
Topics: Animals; Blood Pressure; Body Weight; Heart Rate; Hyperhomocysteinemia; Male; Methionine; Panax; Rats; Rats, Wistar; Saponins | 2006 |
Methionine-loading and random homocysteine tests have no added value in risk assessment for venous and arterial thrombosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arterial Occlusive Diseases; Cohort Studies; Fasting; Female; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Male; Methionine; Middle Aged; Netherlands; Predictive Value of Tests; Retrospective Studies; Risk Assessment; Risk Factors; Thrombosis; Time Factors; Venous Thrombosis | 2007 |
Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice.
Topics: Administration, Oral; Animal Feed; Animals; Catechin; Cystathionine beta-Synthase; DNA Primers; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA; Superoxide Dismutase; Superoxide Dismutase-1 | 2007 |
Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice.
Topics: Animals; Cystathionine beta-Synthase; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mutation | 2007 |
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Topics: Animals; Brain; Disease Models, Animal; Embryo, Mammalian; Female; Ferredoxin-NADP Reductase; Folic Acid; Heart; Homocysteine; Hyperhomocysteinemia; Kidney; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Hyperhomocysteinemia and low methionine stress are risk factors for central retinal venous occlusion in an Indian population.
Topics: Adult; Case-Control Studies; Cysteine; Female; Folic Acid; Glutathione; Homocysteine; Humans; Hyperhomocysteinemia; India; Male; Methionine; Prevalence; Prospective Studies; Retinal Vein Occlusion; Risk Factors; Vitamin B 12 | 2007 |
Effect of lycopene on the vascular endothelial function and expression of inflammatory agents in hyperhomocysteinemic rats.
Topics: Animals; Antioxidants; Aorta, Abdominal; Carotenoids; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Hyperhomocysteinemia; Inflammation; Lycopene; Male; Methionine; Nitric Oxide; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Vascular Cell Adhesion Molecule-1 | 2007 |
Podocyte injury and glomerulosclerosis in hyperhomocysteinemic rats.
Topics: Actinin; Albuminuria; Animals; Creatinine; Glomerulosclerosis, Focal Segmental; Homocysteine; Hyperhomocysteinemia; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Methionine; Microfilament Proteins; Podocytes; Rats; Rats, Sprague-Dawley; Time Factors | 2007 |
Low vitamin B6, and not plasma homocysteine concentration, as risk factor for abdominal aortic aneurysm: a retrospective case-control study.
Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Case-Control Studies; Creatinine; DNA Mutational Analysis; Fasting; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Genetic; Retrospective Studies; Risk Assessment; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B 6 Deficiency | 2007 |
Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial dysfunction.
Topics: Acetylcholine; Acute Disease; Adult; Brachial Artery; Endothelium, Vascular; Female; Humans; Hyperhomocysteinemia; Male; Methionine; Microcirculation; Skin; Vasodilation | 2007 |
Effects of maternal hyperhomocysteinemia induced by high methionine diet on the learning and memory performance in offspring.
Topics: Animals; Animals, Newborn; Brain; Female; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Hyperhomocysteinemia; Male; Maze Learning; Memory; Methionine; Nerve Growth Factors; Neural Cell Adhesion Molecule L1; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Sialic Acids | 2007 |
Hyper-homocysteinemia alters amyloid peptide-clusterin interactions and neuroglial network morphology and function in the caudate after intrastriatal injection of amyloid peptides.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Benzothiazoles; Caudate Nucleus; Clusterin; Drug Interactions; Food, Formulated; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Models, Biological; Pain Measurement; Peptide Fragments; Rats; Rats, Sprague-Dawley; Reaction Time; Thiazoles | 2007 |
The use of an in vivo model to study the effects of hyperhomocysteinaemia on vascular function.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Folic Acid; Hyperhomocysteinemia; Male; Methionine; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Effect of hyperhomocysteinemia on cardiovascular risk factors and initiation of atherosclerosis in Wistar rats.
Topics: Animals; Aorta; Atherosclerosis; C-Reactive Protein; Cardiovascular Diseases; Caveolin 2; Cholesterol; Cysteine; Homocysteine; Hydroxymethylglutaryl CoA Reductases; Hyperhomocysteinemia; In Vitro Techniques; Leukotrienes; Liver; Male; Methionine; Nitric Oxide; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Receptors, Purinergic P2Y2; Resistin; Tunica Media | 2007 |
Experimental hyperhomocysteinemia disturbs bone metabolism in rats.
Topics: Animals; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Collagen Type I; Creatine; Female; Folic Acid; Homocysteine; Hydroxyproline; Hyperhomocysteinemia; Methionine; Osteocalcin; Osteogenesis; Peptides; Rats; Rats, Wistar; Vitamin B 12 | 2007 |
Cystathionine-beta-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells.
Topics: Animals; Cell Adhesion Molecules; Cells, Cultured; Collagen Type I; Cystathionine beta-Synthase; Endothelial Cells; Extracellular Matrix; Genetic Therapy; Homocysteine; Hyperhomocysteinemia; Inflammation Mediators; Matrix Metalloproteinase 9; Methionine; Mice; Nitric Oxide; Nitric Oxide Synthase Type III; Transfection; Tubercidin | 2007 |
Oral challenge with a methionine load in patients with inflammatory bowel disease: a better test to identify hyperhomocysteinemia.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Homocysteine; Humans; Hyperhomocysteinemia; Incidence; Inflammatory Bowel Diseases; Male; Methionine; Middle Aged; Prevalence; Prognosis; Prospective Studies; Risk Factors; Thrombosis; Vitamin B 12 | 2008 |
Homocysteine induces connective tissue growth factor expression in vascular smooth muscle cells.
Topics: Animals; Cells, Cultured; Connective Tissue Growth Factor; Gene Expression Regulation; Homocysteine; Humans; Hyperhomocysteinemia; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Methionine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Umbilical Veins | 2008 |
Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor-kappaB activation.
Topics: Animals; Cells, Cultured; Chemokine CCL2; Homocysteine; Humans; Hyperhomocysteinemia; Kidney; Kidney Tubules, Proximal; Male; Methionine; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2008 |
Modulation of erythrocyte sensitivity to oxidative stress by transient hyperhomocysteinemia in healthy subjects and in patients with coronary artery disease.
Topics: Adult; Aged; alpha-Tocopherol; Analysis of Variance; Area Under Curve; Coronary Artery Disease; Erythrocytes; Female; Homocysteine; Humans; Hyperhomocysteinemia; Lipid Peroxidation; Male; Methionine; Middle Aged; Oxidation-Reduction; Oxidative Stress | 2008 |
Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats.
Topics: Animals; Aorta, Thoracic; Cell Line; Cells, Cultured; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; In Vitro Techniques; Male; Methionine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxides | 2007 |
The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats.
Topics: Acetylcholine; Animals; Disease Models, Animal; Homocysteine; Hydrogen Sulfide; Hyperhomocysteinemia; Liver; Liver Circulation; Liver Cirrhosis; Male; Methionine; Microcirculation; Rats; Rats, Wistar | 2008 |
Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease.
Topics: Adiponectin; Adipose Tissue; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Endoplasmic Reticulum; Ethanol; Homocysteine; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Rats; Rats, Sprague-Dawley | 2008 |
Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats.
Topics: Animals; Arginine; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Diet; Homocysteine; Hyperhomocysteinemia; Male; Mesenteric Arteries; Methionine; Rats; Rats, Wistar; Vasodilation | 2008 |
Methionine loading does not enhance the predictive value of homocysteine serum testing for all-cause mortality or major adverse cardiac events.
Topics: Adult; Female; Heart Diseases; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Predictive Value of Tests | 2009 |
Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice.
Topics: Animals; Atherosclerosis; Diet, Atherogenic; Dietary Supplements; Disease Models, Animal; Female; Homocysteine; Hyaluronic Acid; Hyperhomocysteinemia; Immunohistochemistry; Lipids; Methionine; Mice; Mice, Inbred C57BL | 2008 |
High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism.
Topics: Adult; Aged; Aged, 80 and over; Female; Gene Frequency; Haplotypes; Humans; Hyperhomocysteinemia; Linkage Disequilibrium; Male; Methionine; Middle Aged; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Polymorphism, Single Nucleotide | 2008 |
Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Sensitivity and Specificity | 2008 |
High expression, purification, and properties of recombinant homocysteine alpha, gamma-lyase.
Topics: Animals; Carbon-Sulfur Lyases; Cardiovascular Diseases; Chromatography; Cloning, Molecular; Cysteine; Enzyme Stability; Escherichia coli; Homocysteine; Hydrogen-Ion Concentration; Hyperhomocysteinemia; Kinetics; Methionine; Protein Conformation; Protozoan Proteins; Pseudomonas putida; Pyridoxal Phosphate; Recombinant Proteins; Substrate Specificity; Temperature; Trichomonas vaginalis | 1998 |
Endothelial dysfunction by acute hyperhomocyst(e)inaemia: restoration by folic acid.
Topics: Acute Disease; Adult; Brachial Artery; Endothelium, Vascular; Folic Acid; Humans; Hyperhomocysteinemia; Male; Methionine; Vasodilation | 1999 |
Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Age of Onset; Coronary Disease; Cystathionine beta-Synthase; Fasting; Female; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic | 1999 |
Combination of low-dose folic acid and pyridoxine for treatment of hyperhomocysteinaemia in patients with premature arterial disease and their relatives.
Topics: Adult; Age of Onset; Arteriosclerosis; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Prospective Studies; Pyridoxine; Risk Factors | 1999 |
Hyperhomocysteinemia and hypofibrinolysis in young adults with ischemic stroke.
Topics: Adolescent; Adult; Brain Ischemia; Case-Control Studies; Cerebral Arteries; Cerebrovascular Disorders; Female; Fibrinolysis; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylenetetrahydrofolate Dehydrogenase (NAD+); Mutation; Oxidoreductases; Risk Factors; Vitamins | 1999 |
Determinants of fasting and post-methionine homocysteine levels in families predisposed to hyperhomocysteinemia and premature vascular disease.
Topics: Adult; Age Factors; Amino Acid Substitution; Arteriosclerosis; Body Mass Index; Comorbidity; Fasting; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Lipids; Male; Menopause; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pyridoxine; Smoking; Vitamin B 12 | 1999 |
[Obstetric problems followed by stroke].
Topics: Abortion, Habitual; Adult; Arteriosclerosis; Cerebral Infarction; Diagnosis, Differential; Female; Fetal Death; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Male; Methionine; Nutrition Disorders; Placental Insufficiency; Pregnancy; Pregnancy Complications, Cardiovascular; Pyridoxine; Smoking; Venous Thrombosis; Vitamin B 6 Deficiency | 1999 |
Rapid diagnosis and methionine administration: basis for a favourable outcome in a patient with methylene tetrahydrofolate reductase deficiency.
Topics: Female; Homocystinuria; Humans; Hyperhomocysteinemia; Infant, Newborn; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Time Factors; Treatment Outcome | 1999 |
Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans.
Topics: Acetylcholine; Adult; Antioxidants; Ascorbic Acid; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitroprusside; Oxidative Stress; Vasodilation; Vasodilator Agents; Verapamil | 1999 |
Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; DNA Mutational Analysis; DNA, Complementary; Enzyme Activation; Ferredoxin-NADP Reductase; Folic Acid; Genes, Recessive; Genetic Complementation Test; Heteroduplex Analysis; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Mutation; Polymorphism, Single-Stranded Conformational; Reverse Transcriptase Polymerase Chain Reaction; RNA Splicing; Sequence Analysis, DNA; Vitamin B 12 | 1999 |
Influence of homocysteine on matrix metalloproteinase-2: activation and activity.
Topics: Cysteine; Enzyme Activation; Enzyme Precursors; Gelatin; Gelatinases; Glutathione; Homocysteine; Homocystine; Humans; Hyperhomocysteinemia; Matrix Metalloproteinase 2; Metalloendopeptidases; Methionine | 1999 |
Familial hyperhomocysteinaemia and endothelium-dependent vasodilatation and arterial distensibility of large arteries.
Topics: Adult; Brachial Artery; Carotid Artery, Common; Endothelium, Vascular; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Regional Blood Flow; Regression Analysis; Vascular Diseases; Vasodilation | 1999 |
Effect of short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia.
Topics: Administration, Oral; Adult; Blood Flow Velocity; Drug Therapy, Combination; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxine; Treatment Outcome; Vasodilation; Vitamin B 12 | 1999 |
Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults.
Topics: Adult; Aged; Aging; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Oxidation-Reduction; Prospective Studies; Vasodilation | 2000 |
Normohomocysteinaemia and vitamin-treated hyperhomocysteinaemia are associated with similar risks of cardiovascular events in patients with premature atherothrombotic cerebrovascular disease. A prospective cohort study.
Topics: Adult; Arteriosclerosis; Female; Folic Acid; Follow-Up Studies; Hematinics; Humans; Hyperhomocysteinemia; Ischemic Attack, Transient; Male; Mass Screening; Methionine; Middle Aged; Proportional Hazards Models; Prospective Studies; Pyridoxine; Risk Assessment; Risk Factors; Stroke; Treatment Outcome | 2000 |
[Should we consider hyperhomocysteinemia as a vascular risk factor?].
Topics: Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Polymorphism, Genetic; Risk Factors; Thrombosis; Vitamin B Complex | 2000 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenobarbital; Phenytoin; Primidone; Treatment Outcome; Valproic Acid; Vitamin B 12 | 2000 |
Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia.
Topics: Animals; Arginine; Cell Line, Transformed; Cholesterol; Diet; Dietary Fats; Endothelium, Vascular; Enzyme Inhibitors; Homocysteine; Humans; Hypercholesterolemia; Hyperhomocysteinemia; Macaca fascicularis; Methionine; Nitric Oxide Synthase; Regression Analysis; Vasodilation | 2000 |
Investigation of methionine metabolism in peripheral blood mononuclear cells of Irish hyperhomocysteinemic subjects.
Topics: Chromatography, Thin Layer; Humans; Hyperhomocysteinemia; Methionine; Monocytes | 1998 |
The (non-)sense of the methionine loading test for detecting hyperhomocysteinaemia.
Topics: Cardiovascular Diseases; Fasting; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Mass Screening; Methionine | 2000 |
[Homocysteine and its metabolites in chronic renal insufficiency and the effect of a vitamin replacement].
Topics: Adult; Aged; Arteriosclerosis; Cysteine; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methionine; Middle Aged; Pyridoxine; Renal Dialysis; Severity of Illness Index; Vitamin B 12; Vitamin B Complex | 2000 |
Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury.
Topics: Administration, Oral; Angioplasty, Balloon; Animals; Carotid Arteries; Carotid Artery Diseases; Cystine; Diet; Dose-Response Relationship, Drug; Folic Acid; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Male; Methionine; Rats; Rats, Sprague-Dawley; Tunica Intima; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
Is there a role of cyclosporine A on total homocysteine export from human renal proximal tubular epithelial cells?
Topics: Biological Transport, Active; Cells, Cultured; Cyclosporine; Epithelial Cells; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Kidney Transplantation; Kidney Tubules, Proximal; Methionine; Pyridoxine; Vitamin B 12 | 2001 |
Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans.
Topics: Acute Disease; Adult; Arginine; Brachial Artery; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitroglycerin; Vasodilation; Vasodilator Agents | 2001 |
Clinical relevance of the methionine loading test for assessment of hyperhomocysteinaemia.
Topics: Cardiovascular Diseases; Fasting; Homocysteine; Humans; Hyperhomocysteinemia; Mass Screening; Methionine; Risk Factors | 2000 |
Thromboangiitis obliterans (Buerger's disease).
Topics: Humans; Hyperhomocysteinemia; Methionine; Smoking; Thromboangiitis Obliterans | 2001 |
Effects of methionine loading on plasma and erythrocyte sulphur amino acids and sulph-hydryls before and after co-factor supplementation in haemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids, Sulfur; Case-Control Studies; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Pyridoxine; Renal Dialysis; Sulfhydryl Compounds | 2001 |
Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model.
Topics: Animals; Apolipoproteins E; Arteriosclerosis; Cells, Cultured; Diet; Disease Models, Animal; Folic Acid; Humans; Hyperhomocysteinemia; Immunohistochemistry; Male; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridoxine; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thromboplastin; Vascular Cell Adhesion Molecule-1; Vasculitis; Vitamin B 12 | 2001 |
Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study.
Topics: Adult; Cardiovascular Diseases; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Risk Factors | 2001 |
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Brain; Chronic Disease; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Folic Acid; Food, Fortified; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Thrombomodulin; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 2001 |
The (non-)sense of the methionine loading test for detecting hyperhomocysteinemia is not ready for a compromise.
Topics: Diagnosis, Differential; Humans; Hyperhomocysteinemia; Methionine; Vitamins | 2001 |
Cystatin C is an independent predictor of fasting and post-methionine load total homocysteine concentrations among stable renal transplant recipients.
Topics: Adult; Aged; Biomarkers; Cystatin C; Cystatins; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Transplantation; Male; Methionine; Middle Aged; Regression Analysis | 2001 |
Mild hyperhomocysteinemia: vitamin supplementation or not?
Topics: Adult; Case-Control Studies; Dietary Supplements; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Mutation; Polymorphism, Genetic; Vascular Diseases; Vitamins | 2001 |
Hydrocephalus internus in two patients with 5,10-methylenetetrahydrofolate reductase deficiency.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Cerebral Ventricles; Demyelinating Diseases; Female; Homocysteine; Humans; Hydrocephalus; Hyperhomocysteinemia; Infant; Infant, Newborn; Magnetic Resonance Imaging; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases | 2000 |
Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice.
Topics: Animals; Aortic Diseases; Apolipoproteins E; Arteriosclerosis; Collagen; Coronary Artery Disease; Dietary Supplements; Female; Homocysteine; Hyperhomocysteinemia; Lipids; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Thrombosis | 2001 |
A dysmethylation syndrome, bound to folates and/or vitamin B12 and/or methionine abnormalities? Diagnosis, prevention and treatment considerations.
Topics: DNA Methylation; Folic Acid Deficiency; Hematologic Diseases; Humans; Hyperhomocysteinemia; Iatrogenic Disease; Methionine; Methylation; Neoplasms; Nervous System Diseases; Selenium; Vascular Diseases; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 2001 |
Hyperhomocysteinemia in liver cirrhosis: mechanisms and role in vascular and hepatic fibrosis.
Topics: Arteriosclerosis; Cells, Cultured; Female; Fibrosis; Homocysteine; Humans; Hyperhomocysteinemia; Liver; Liver Cirrhosis; Male; Methionine; Middle Aged; Models, Chemical; Muscle, Smooth, Vascular; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2001 |
Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine.
Topics: Amidohydrolases; Animals; Aorta; Arginine; Arteriosclerosis; Cattle; Cell Line; Culture Techniques; Endothelium, Vascular; Homocysteine; Hydrolases; Hyperhomocysteinemia; Kinetics; Methionine; Nitric Oxide; Nitric Oxide Synthase; Recombinant Fusion Proteins; Signal Transduction | 2001 |
Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects.
Topics: Aged; Aged, 80 and over; Aging; Dementia; Diabetes Complications; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Inflammatory Bowel Diseases; Kinetics; Linear Models; Male; Methionine; Nutrition Disorders; Odds Ratio; Renal Insufficiency; Vascular Diseases | 2001 |
Hyperhomocysteinaemia and folate deficiency in human immunodeficiency virus-infected children.
Topics: Adolescent; Anti-HIV Agents; Child; Child, Preschool; Female; Folic Acid Deficiency; HIV Infections; HIV-1; Homocysteine; Humans; Hyperhomocysteinemia; Infant; Male; Methionine; Statistics as Topic; Vitamin B 12 | 2001 |
Hyperhomocysteinemia in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Topics: Adult; Age Distribution; Biopsy; Case-Control Studies; Cerebral Arterial Diseases; Dementia, Multi-Infarct; Dementia, Vascular; DNA Mutational Analysis; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Phenotype; Risk Factors; Sex Distribution | 2001 |
Diet-induced mild hyperhomocysteinemia and increased salt intake diminish vascular endothelial function in a synergistic manner.
Topics: Acetylcholine; Animals; Blood Glucose; Blood Pressure; Carotid Artery, Common; Drug Synergism; Endothelium, Vascular; Folic Acid; Heart Rate; Homocysteine; Hyperhomocysteinemia; Japan; Kidney; Lipid Peroxidation; Lipids; Male; Methionine; Natriuresis; Nitrites; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sodium Chloride, Dietary | 2002 |
Determination of total homocysteine in plasma: comparison of the Abbott IMx immunoassay with high performance liquid chromatography.
Topics: Adult; Chromatography, High Pressure Liquid; False Negative Reactions; Fasting; Female; Homocysteine; Humans; Hyperhomocysteinemia; Immunoassay; Male; Methionine; Middle Aged; Photochemistry; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; Thrombophilia; Thrombosis | 2002 |
Implications of hyperhomocysteinemia in glomerular sclerosis in hypertension.
Topics: Animals; Chromatography, High Pressure Liquid; Diet; Disease Models, Animal; Glomerular Mesangium; Homocysteine; Hyperhomocysteinemia; Hypertension; Methionine; Rats; Rats, Sprague-Dawley; Salts; Sclerosis | 2002 |
Niacin (nicotinic acid) in non-physiological doses causes hyperhomocysteineaemia in Sprague-Dawley rats.
Topics: Animals; Dietary Supplements; Dose-Response Relationship, Drug; Eating; Hyperhomocysteinemia; Liver; Male; Methionine; Niacin; Organ Size; Rats; Rats, Sprague-Dawley; Vitamin B 12; Vitamin B 6; Weight Gain | 2002 |
Methionine-loading test: evaluation of adverse effects and safety in an epidemiological study.
Topics: Arteriosclerosis; Blood Pressure; Cohort Studies; Dizziness; Epidemiologic Studies; Female; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Nausea; Polymers; Safety | 2002 |
Adverse event associated with methionine loading test: a case report.
Topics: Administration, Oral; Aged; Black or African American; Brain Death; Disease Susceptibility; Drug Contamination; Drug Overdose; Fatal Outcome; Female; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Inactivation, Metabolic; Metabolism, Inborn Errors; Methionine | 2002 |