methionine has been researched along with Fatty Liver, Nonalcoholic in 317 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 192 (60.57) | 24.3611 |
| 2020's | 125 (39.43) | 2.80 |
| Authors | Studies |
|---|---|
| Ballentine, SJ; Brunt, EM; Davidson, NO; Molitor, EA; Newberry, EP; Soleymanjahi, S; Xie, Y | 1 |
| Guo, X; Han, J; Kawai, D; Koyama, T; Motoo, Y; Satoh, T; Yamada, S; Yamaguchi, R; Zhang, J; Zhou, X | 1 |
| Chen, A; Wang, H; Yin, Q; Zhang, B; Zhang, C | 1 |
| Ding, J; Dou, GR; Duan, JL; Fang, ZQ; Liu, JJ; Ruan, B; Song, P; Wang, L; Xu, C; Xu, H; Yue, ZS | 1 |
| Bian, D; Gan, J; Liu, R; Wang, C; Wen, F; Wu, X | 1 |
| Alastrué-Vera, V; Arnal, C; Barranquero, C; García-Gil, A; Gascón, S; Gonzalo-Romeo, G; Güemes, A; Gutiérrez-Blázquez, D; Herrera-Marcos, LV; Herrero-Continente, T; Lou-Bonafonte, JM; Macías-Herranz, M; Martínez-Beamonte, R; Osada, J; Puente-Lanzarote, JJ; Rodríguez-Yoldi, MJ; Surra, JC | 1 |
| Ahmeda, AF; Al Zarzour, RH; Alsalahi, A; Alshawsh, MA; Alshehade, SA; Mahmoud, AM; Saghir, SAM | 1 |
| Cheng, C; Deng, J; Liu, F; Liu, X; Lyu, J; Peng, H; Qiao, Y; Wan, Q; Wang, Y; Zheng, H; Zou, C | 1 |
| Chen, H; Li, C; Liu, X; Wang, P; Wu, C; Yang, X; Yang, Y; Yao, S; Yin, R; Yu, M; Zhou, B | 1 |
| Tang, W; Wang, H; Wu, Y | 1 |
| Duan, J; Li, Y; Liu, B; Pu, G; Wang, C; Wang, G; Xiu, W; Xu, J; Ye, C; Zhu, Y | 1 |
| Colares, JR; da Silva, JB; Hartmann, RM; Marroni, CA; Marroni, NP; Miguel, FM; Picada, JN; Schemitt, EG | 1 |
| Navik, U; Sharma, N; Sheth, VG; Tikoo, K | 1 |
| Albano, E; Gadipudi, LL; Perretti, M; Provera, A; Ramavath, NN; Reutelingsperger, C; Sutti, S | 1 |
| Guo, Q; Ji, L; Kai, G; Lu, B; Miao, H; Ouyang, H; Wei, M | 1 |
| Balkrishna, A; Bhattacharya, K; Dev, R; Gohel, V; Kumari, P; Manik, M; Varshney, A | 1 |
| Cheng, S; Ding, N; Dong, H; Fan, X; Jiang, H; Liu, J; Wang, K; Xu, Y; Yang, M; Yu, J; Zhang, L; Zou, Q | 1 |
| Cai, L; Jiang, F; Li, Z; Lian, B; Lin, F; Zhang, XK; Zhang, Z | 1 |
| Alpini, G; Francis, H; Glaser, S; Guo, X; Li, H; Li, Q; Lu, B; Wang, F; Wu, C; Xie, L; Zhu, B | 1 |
| Dai, Y; Fang, C; Feng, M; Huang, B; Jia, Z; Li, Y; Liu, J; Liu, L; Wu, H; Xiao, H; Yan, X; Zhang, Y; Zhu, M | 1 |
| Ji, G; Liu, BC; Lu, AP; Tan, YY; Wang, RR; Yue, SR; Zhang, L | 1 |
| Jeong, W; Kang, YH; Kim, N; Kwon, M; Lee, GR; Lee, HI; Lee, J; Song, HJ; Yeo, CY | 1 |
| Cagna, M; Croce, AC; Di Pasqua, LG; Ferrigno, A; Mannucci, B; Palladini, G; Perlini, S; Profumo, A; Vairetti, M | 1 |
| Jeon, MS; Kim, M; Li, J; Liu, Z; Peng, H; Wang, X; Wu, J; Xie, L; Xu, H; Zhang, KK | 1 |
| Chen, TQ; Deng, YF; Mao, LN; Ming, JX; Ren, H; Sun, WG; Wang, YF; Xu, QQ; Zhang, YH; Zhou, JJ; Zhou, Q | 1 |
| Abdul Ghani, SAB; Arul, K; Bee, GGB; Cheah, CC; Chow, PKH; Cook, SA; Lim, TR; Pei, HJ; Sandireddy, R; Shekeran, SG; Singh, BK; Singh, MK; Sinha, RA; Suzuki, A; Tikno, K; Tripathi, M; Wang, J; Widjaja, A; Wong, KA; Xiao, RP; Yen, PM; Zhang, X; Zhou, J | 1 |
| Le, G; Lu, M; Qian, J; Xie, Y; Xu, Y; Yang, Y | 1 |
| Du, A; Ji, L; Jia, W; Li, J; Lu, W; Wang, K; Xu, H; Zhang, S | 1 |
| Hu, PX; Liu, YP; Sheng, MY; Zhang, CQ | 1 |
| Chang, X; Hou, J; Tang, S; Yang, W; Yao, D; Zheng, S | 1 |
| Gong, J; Liu, L; Liu, S; Liu, X; Tao, Y; Wang, Y; Wei, W; Zhao, X | 1 |
| Guo, J; Kang, Y; Li, C; Luo, Y; Song, J; Song, Y; Yang, S; Yu, J; Zhang, X | 1 |
| Kong, W; Liu, J; Liu, L; Liu, Y; Tang, Y; Zhang, G | 1 |
| Ge, X; Guo, S; Jiao, T; Li, C; Liu, Y; Nan, F; Wang, K; Wang, Y; Xie, C; Xie, X; Yin, J; Zhang, C | 1 |
| Hu, J; Li, L; Ma, H; Ying, H; Zhao, Y; Zheng, Y | 1 |
| Bily, D; Cheng, H; Ding, Z; He, L; Liu, L; Wang, X; Wu, C; Xie, L; Zhang, K | 1 |
| Guo, J; Kang, Y; Li, C; Luo, Y; Song, Y; Sun, D; Ye, L; Yin, F; Yu, J; Zhang, X | 1 |
| Chen, YX; Guo, CJ; Hua, J; Ji, PX; Li, XY; Lian, M; Ni, XX; Sheng, L | 1 |
| Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y | 1 |
| Chen, F; Hu, S; Hu, Y; Li, HW; Luo, ZP; Pan, LX; Peng, L; Wang, JP; Wang, SX; Wu, YC; Xu, T; Yang, CC; Yang, JF; Yao, Y | 1 |
| Gao, W; Guo, L; Huang, L; Liang, Y; Ma, L; Man, S; Yan, M | 1 |
| Gong, F; Jia, S; Li, X; Lin, D; Liu, Z; Pan, J; Sun, Q; Wang, S; Zheng, M; Zhu, J | 1 |
| Aljobaily, N; Cone, B; Han, Y; Joly, R; Krutsinger, K; Menlove, B; Suppes, A; Viereckl, MJ | 1 |
| Gao, W; Liu, P; Liu, W; Qi, S; Shi, S; Wang, H; Wang, S; Wang, Y; Wu, J; Xu, Y; Zhang, L; Zhang, Q | 1 |
| Cooper, SG; Feng Earley, Y; Gayban, AJB; Kleemann, R; Regalado, E; Souza, LAC | 1 |
| Buechler, C; Girke, P; Haberl, EM; Krautbauer, S; Liebisch, G; Mages, W; Pohl, R; Rein-Fischboeck, L | 1 |
| Chen, Q; Fan, Y; Gong, G; Huang, X; Huang, Y; Song, Y; Xi, S; Xu, H; Yan, C; Yang, R; Zhang, B | 1 |
| Bian, C; Guo, X; Liang, Q; Lu, Z; Wang, H; Zhao, X; Zhen, Q; Zheng, Y | 1 |
| Li, H; Li, W; Lv, S; Pan, B; Su, X; Wang, X; Wang, Y; Zhang, H; Zhang, Z | 1 |
| Chen, R; Dong, H; Fan, W; Guo, C; Guo, L; Li, Q; Qu, X; Wang, X; Zhang, X; Zhang, Y | 1 |
| Chen, R; Du, H; Li, F; Lin, L; Luo, X; Ruan, C; Wu, S; Wu, Y; Zhang, X | 1 |
| Geng, J; Han, M; Li, X | 1 |
| Alarcon, PC; Damen, MSMA; Divanovic, S; Giles, DA; Moreno-Fernandez, ME; Oates, JR; Sawada, K; Stankiewicz, TE; Szabo, S | 1 |
| Ding, P; Li, H; Sun, J; Weng, L; Xiang, W; Yang, Y; Ye, Z; Zeng, C | 1 |
| Gong, X; Hu, J; Jiang, N; Kuang, G; Liu, H; Liu, J; Wan, J; Wu, S; Yin, X | 1 |
| Barbieri, A; Campagnoli, LIM; Croce, AC; Di Pasqua, LG; Ferrigno, A; Marchesi, N; Pascale, A; Vairetti, M | 1 |
| Albuquerque, M; Boulanger, CM; Calmels, M; Casteleyn, C; Gilgenkrantz, H; Hammoutene, A; Paradis, V; Pravisani, R; Rautou, PE; Sadoine, J; Slimani, L; Tanguy, M | 1 |
| Chen, Z; Chu, W; Li, P; Liu, Y; Mi, Y; Niu, B; Wu, X; Zhou, H; Zhou, Y | 1 |
| Abe, A; Miyajima, K; Nakae, D; Nakane, S; Suzuki-Kemuriyama, N; Yuki, M | 1 |
| Choi, H; Choi, J; Chung, J | 1 |
| Chen, Y; Wang, J; Zhai, T | 1 |
| Do, IG; Kim, J; Kim, SH; Lee, Y; Park, CY; Song, Y; Yang, H | 1 |
| Chen, J; Fang, Y; Huang, L; Liang, G; Lin, J; Liu, X; Luo, W; Qian, C; Wang, Y; Xie, L; Zuo, W | 1 |
| Hardwick, JP; Lee, M; Lee, YK; Mifflin, R; Novak, R; Park, JE; Xu, Y; Zhang, Y | 1 |
| Gee, HY; Kim, DY; Park, JY | 1 |
| Kuttner, CS; Lammert, F; Mancina, R; Stokes, CS; Wagenpfeil, G | 1 |
| Arista Romeu, EJ; Campos-Espinosa, A; de la Rosa Vázquez, JM; Escobedo, G; Fabila Bustos, DA; Guzmán, C; Moreno-González, J; Romero-Bello, II; Stolik, S; Valor, A | 1 |
| Carvajal, S; Casals, E; Casals, G; Fernández-Varo, G; González de la Presa, B; Jiménez, W; Morales-Ruíz, M; Oró, D; Parra, M; Pastor, Ó; Perramón, M; Puntes, V; Ribera, J | 1 |
| Buechler, C; Feder, S; Haberl, EM; Krautbauer, S; Liebisch, G; Pohl, R; Rein-Fischboeck, L | 1 |
| Codella, R; Luzi, L; Mollica, G; Montesano, A; Senesi, P; Terruzzi, I; Vacante, F | 1 |
| Kim, B; Kim, JW; Lim, CW; Qi, J; Zhou, Z | 1 |
| Chen, X; Huang, YM; Li, CP; Lü, MH; Shi, L; Wang, XM; Wang, XY | 1 |
| Choi, SJ; Kim, B; Kim, JW; Lee, K; Lee, SH; Lim, CW; Park, S; Yun, H; Zhou, Z | 1 |
| Ge, K; Jia, C; Lu, J; Zhu, H | 1 |
| Kim, SJ; Kwon, OS; Lee, DE; Lee, HS; Lee, SJ | 1 |
| Elmér, E; Gallay, P; Gregory, M; Grönberg, A; Hansson, MJ; Kuo, J; Longato, L; Massoumi, R; Mazza, G; Moss, S; Pinzani, M; Rombouts, K; Simón Serrano, S | 1 |
| Angulo, S; Carril, E; Godzien, J; Lanzón, B; Rupérez, FJ; Valdecantos, MP; Valverde, ÁM | 1 |
| de Vito, C; Dibner, C; Jornayvaz, FR; Loizides-Mangold, U; Montandon, SA; Somm, E | 1 |
| Chen, Y; Fan, Y; Sun, R; Tian, Z; Wei, H; Zhang, W | 1 |
| Chmurzynska, A; Martínez, JA; Milagro, FI; Muzsik, A; Radziejewska, A | 1 |
| Fu, R; He, Q; Jiang, R; Liu, Y; Lu, Y; Sun, B; Sun, Q; Tian, W; Wang, J; Xu, X; Yu, H; Zhang, Z | 1 |
| Gong, X; Hu, J; Kuang, G; Liu, J; Wan, J; Wu, S; Yin, X; Yuan, Y; Zhang, L; Zhang, X; Zhou, Q | 1 |
| Jiang, M; Li, HK; Li, LY; ShangGuan, T; Sun, WW; Yang, P; Zhang, ZH; Zhu, P | 1 |
| Alonso, C; Aspichueta, P; Barbier-Torres, L; Bizkarguenaga, M; Buqué, X; Cabrera, D; Castro, A; Crespo, J; Delgado, TC; Falcón-Pérez, JM; Fernández-Ramos, D; Fernández-Tussy, P; Goikoetxea-Usandizaga, N; Gómez-Santos, B; Gutiérrez-de Juan, V; Iruzubieta, P; Lopitz-Otsoa, F; Lu, SC; Martínez-Chantar, ML; Mato, JM; Nogueiras, R; Nuñez-García, M; Rodriguez-Agudo, R; Romero-Gomez, M; Serrano-Macia, M; Simon, J; van Liempd, S; Varela-Rey, M; Villa, E; Zubiete-Franco, I | 1 |
| Deng, D; Hirano, E; Igarashi, K; Kaku, T; Lim, HS; Miyai, H; Nakamura, J; Shindo, T; Sugimoto, K; Toledo, A; Tone, T; Yamauchi, A | 1 |
| Guan, KL; Huang, X; Li, X; Li, Y; Liu, J; Sun, T; Wang, TX; Xiong, Y; Yuan, HX; Zang, S | 1 |
| Cai, K; Jiang, B; Li, X; Sheng, L; Song, Y; Wu, W | 1 |
| Alén, R; Barbas, C; Carrascosa, JM; García-Martínez, I; García-Rodríquez, JJ; Gribble, FM; Guijarro, LG; Lu, VB; Menchén, L; Puerto, M; Reimann, F; Rubio, C; Ruperez, J; Saiz, J; Sanmartín-Salinas, P; Toledo-Lobo, MV; Valverde, ÁM | 1 |
| Arao, Y; Hayatsu, M; Kamimura, K; Kawai, H; Kobayashi, T; Nakano, O; Terai, S; Ushiki, T | 1 |
| Cho, YY; Han, SH; Jang, JH; Jang, JK; Kang, HC; Kim, SW; Lee, HS; Lee, JY; Ma, KH; Yang, G | 1 |
| Chen, J; Cui, A; Gao, J; Han, J; Ji, S; Li, J; Li, Y; Liu, Z; Ma, F; Ma, X; Tai, P; Wang, G; Wang, T; Xue, Y | 1 |
| Jiang, Q; Li, G; Liu, B; Xu, K; Zhang, J | 1 |
| Andreola, F; Argemi, J; Bataller, R; Caballeria, J; Cowart, LA; De Chiara, F; Fondevila, C; Fox, T; Frenguelli, L; Kester, M; Levi, A; Longato, L; Luong, TV; Massey, V; Mazza, G; Montefusco, D; Omenetti, S; Pinzani, M; Rombouts, K; Shanmugavelandy, SS; Zanieri, F | 1 |
| Che, Y; Li, Y; Shi, X; Shi, Y; Si, R; Zhang, Y; Zhong, X | 1 |
| Hojo, N; Kanji, H; Kanzaki, K; Kawakami, T; Kawakami, Y; Kimura, Y; Mori, Y; Otsuki, A; Suzuki-Yamamoto, T; Takahashi, Y; Tanaka, R; Tsukayama, I | 1 |
| Chen, H; Huang, C; Ke, Z; Li, Y; Tan, S; Zhao, Y; Zhou, Z | 1 |
| Bonnafous, S; Delaunay, F; Gréchez-Cassiau, A; Gual, P; Guérin, S; Leclère, PS; Luci, C; Patouraux, S; Rousseau, D; Ruberto, AA; Subramaniam, M; Teboul, M; Tran, A | 1 |
| Bochaton-Piallat, ML; De Vito, C; Dibner, C; Gaïa, N; Jornayvaz, FR; Lazarevic, V; Loizides-Mangold, U; Montandon, SA; Perroud, E; Schrenzel, J; Somm, E | 1 |
| Cai, Z; Deng, L; Hu, L; Li, Z; Ren, Q; Wang, B; Wang, G; Zhou, Z | 1 |
| Jadžić, J; Jorgačević, B; Labudović-Borović, M; Mladenović, D; Radosavljević, T; Vesković, M; Vučević, D; Vukićević, D | 1 |
| Eto, H; Hyodo, F; Kang, JH; Katayama, Y; Kishimura, A; Li, J; Mori, T; Mu, Y; Zai, K | 1 |
| Doskey, CM; Fader, KA; Fling, RR; Nault, R; Zacharewski, TR | 1 |
| Balint-Lahat, N; Ben-Ari, Z; Brzezinski, RY; Finchelman, JM; Grossman, E; Hoffer, O; Leor, J; Levin-Kotler, L; Lewis, N; Naftali-Shani, N; Ovadia-Blechman, Z; Rabin, N; Safran, M; Sternfeld, A; Tepper-Shaihov, O; Unis, R; Zimmer, Y | 1 |
| Alonso, C; Azkargorta, M; Bilbao, J; Bizkarguenaga, M; Delacruz-Villar, L; Elortza, F; Fernández-Ramos, D; Goni, FM; Hayardeny, L; Iruarrizaga-Lejarreta, M; Lopitz-Otsoa, F; Lu, SC; Martínez-Chantar, ML; Mato, JM; Mosca, L; Pagano, M; Serrano-Macia, M; Sot, J; Tsvirkun, D; van Liempd, SM | 1 |
| Cardini, B; Fodor, M; Hautz, T; Hermann, M; Maglione, M; Margreiter, C; Mellitzer, V; Oberhuber, R; Öfner, D; Resch, T; Schneeberger, S; Schwelberger, H; Tilg, H; Troppmair, J; Weißenbacher, A; Wieser, V; Zelger, B | 1 |
| Hata, K; Hiwatashi, K; Naya, Y; Ogihara, K; Sasaki, A; Takahashi, J; Toshima, G | 1 |
| Buechler, C; Haberl, EM; Höring, M; Krautbauer, S; Liebisch, G; Pohl, R; Rein-Fischboeck, L | 1 |
| Berardo, C; Di Pasqua, LG; Ferrigno, A; Palladini, G; Perlini, S; Rizzo, V; Vairetti, M | 1 |
| Abe, A; Miyajima, K; Nakae, D; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M | 1 |
| Fierro, R; González-Márquez, H; Guéant, JL; Guéant-Rodríguez, RM; Marchal, A; Sámano-Hernández, L | 1 |
| Gu, H; Jia, K; Liu, P; Pan, M; Shen, Z; Sun, C; Yang, K | 1 |
| Kong, LY; Leng, YR; Li, J; Yang, T; Ye, ST; Zhang, H; Zhang, MH; Zhang, YQ; Zhu, XY | 1 |
| Arrese, M; Cabrera, D; Hernández, A; Jara, E; Kalergis, AM; Muñoz-Durango, N | 1 |
| Goto, H; Hidoh, Y; Ishii, Y; Nishimura, Y; Sato, M; Takeuchi, K; Yokouchi, C | 1 |
| Baek, J; Basavarajappa, L; Hoyt, K; Parker, KJ; Reddy, S; Rijal, G; Song, J; Tai, H | 1 |
| Fan, X; Gu, N; Guo, Q; Hu, H; Oh, Y; Wei, X; Xin, Y; Yang, D; Yue, L; Zhang, B; Zhang, X | 1 |
| Choi, SE; Han, SJ; Heo, YJ; Jeon, JY; Kang, Y; Kim, DJ; Kim, HJ; Lee, KW; Lee, N | 1 |
| Gong, MJ; Han, B; Huang, P; Zhu, CY; Zou, ZJ | 1 |
| Dong, X; Strand-Amundsen, RJ; Sun, X; Tonnessen, TI; Yang, R; Zhu, S | 1 |
| Bassirian, M; Changizi, Z; Komeili-Movahhed, T; Moslehi, A | 1 |
| Breitkopf-Heinlein, K; Ding, H; Gaitantzi, H; Jiang, Q; Li, G; Li, Q; Liu, B; Riedemann, G; Xu, K; Zeng, A | 1 |
| He, J; Huang, C; Huang, H; Jing, X; Li, Y; Liu, Q; Tang, Q; Wu, T; Xia, Y; Xiao, J; Yan, J; Zhang, G; Zhang, J; Zhang, Z; Zhao, Y; Zhou, J | 1 |
| Ji, G; Li, C; Li, M; Shu, X; Zhang, L; Zhou, W | 1 |
| Lin, K; Lu, J; Ni, J; Tang, H; Wu, G; Zhao, H; Zhu, Y | 1 |
| Chen, J; Gu, X; Luo, H; Su, C; Tang, J; Xiao, L; Xiong, F; Zha, L; Zhao, Y; Zheng, Z | 1 |
| Cheng, LH; Cui, S; Ge, CL; Guo, YT; Hao, HP; He, QX; Pan, XJ; Wang, GJ; Wang, H; Yan, TT; Zhang, PF; Zhou, JY | 1 |
| Lai, X; Wu, H; Yang, SH; Yi, ZJ | 1 |
| Alpini, G; Francis, H; Glaser, S; Li, H; Li, Q; Matthews, DR; Wu, C; Zhou, J | 1 |
| Bai, L; Diao, N; Qin, B | 1 |
| Du, A; Huang, Z; Ji, L; Lu, B; Miao, H; Yan, S; Zhang, S | 1 |
| Fan, JG; Fan, SJ; Fu, R; Huang, HM; Huang, J; Li, GM; Li, X; Liao, LP; Liu, YJ; Luo, C; Shi, CC; Yu, L; Zhang, YY; Zhou, XR | 1 |
| Cortopassi, G; Hui, CK; Jiang, JX; Montgomery, C; Tomilov, A; Török, NJ | 1 |
| Abe, A; Miyajima, K; Nakae, D; Nakane, S; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M | 1 |
| Ai, Y; Li, J; Liu, L; Peng, C; Sun, Z; Xiao, X | 1 |
| Alfaro, M; Chintapalli, SV; Kang, P; Shankar, K; Thakali, KM; Wankhade, UD; Zhong, Y | 1 |
| Bok, R; Carroll, V; Di Gialleonardo, V; Keshari, KR; Ohliger, MA; Sai, V; Taylor, A; VanCriekinge, M; Von Morze, C; Wang, ZJ; Wilson, DM | 1 |
| Badiali, S; Baselli, GA; Bassani, GA; Dongiovanni, P; Facciotti, F; Fargion, S; Gatti, S; Maggioni, M; Meroni, M; Pietrelli, A; Rametta, R; Trunzo, V; Valenti, L | 1 |
| Hara, M; Ichimura, M; Kikuchi, K; Matsumoto, K; Miyakawa, H; Moritoki, Y; Omagari, K; Tsunashima, H; Tsuneyama, K; Yasuda, I | 1 |
| Allen, TL; Febbraio, MA; Henstridge, DC; Kammoun, HL; Kraakman, MJ; Peijs, L; Rose-John, S | 1 |
| Aoyama, T; Fang, ZZ; Fujimori, N; Golla, S; Gonzalez, FJ; Hu, X; Krausz, KW; Lu, Y; Takahashi, S; Tanaka, N | 1 |
| Barney, J; Hamad, OM; Hennig, B; Hoffman, JB; Morris, AJ; Petriello, MC; Thompson, B; Wahlang, B; Wang, C | 1 |
| Bedossa, P; Geys, L; Lijnen, HR; Roose, E; Scroyen, I; Vanhoorelbeke, K | 1 |
| Alpini, G; Demieville, J; Francis, H; Hargrove, L; Kennedy, L; Stephenson, K; Thomson, J | 1 |
| Bogaerts, E; Devisscher, L; Geerts, A; Guilliams, M; Lefere, S; Paridaens, A; Raevens, S; Scott, CL; Van Vlierberghe, H; Verhelst, X | 1 |
| Addante, A; Barahona, I; García-Monzón, C; González-Rodríguez, Á; Laiglesia, LM; Moreno-Aliaga, MJ; Pardo, V; Rada, P; Rey, E; Ruiz, L; Sánchez, A; Valdecantos, MP; Valverde, ÁM | 1 |
| Cherrington, NJ; Li, H; Toth, E | 1 |
| Deng, X; Li, G; Liu, B; Xin, S; Xu, K; Zhang, H; Zhang, J; Zhang, N | 1 |
| Kang, BH; Lee, WK; Min, BH; Park, JS; Shim, YJ | 1 |
| Beretta, L; Fallon, M; Gjuka, D; Harrison, SA; Ioannou, GN; Shen, H; Song, X; Stevenson, HL; Wang, J; Yoo, SY; Yoo, W | 1 |
| Buechler, C; Feder, S; Haberl, EM; Krautbauer, S; Liebisch, G; Pohl, R; Rein-Fischboeck, L; Schmid, V | 1 |
| Alshammari, GM; Balakrishnan, A; Chinnasamy, T | 1 |
| Buechler, C; Feder, S; Haberl, EM; Pohl, R; Rein-Fischboeck, L; Sinal, CJ | 1 |
| Han, DH; Jo, YS; Kim, KH; Kim, SH; Lee, MS; Lee, YH | 1 |
| Cho, T; Mak, A; Uetrecht, J | 1 |
| Cho, PJ; Jeon, TW; Jeong, TC; Jo, JJ; Ki, SH; Kim, KM; Kwon, OK; Lee, S; Lee, TH; Na, AY; Shrestha, R | 1 |
| Cao, Q; Ding, Y; Jiang, Y; Jin, L; Jing, M; Lu, J; Wu, C; Yang, L | 1 |
| Chen, X; Fang, M; Kong, M; Xu, H; Xu, Y | 1 |
| Bian, XY; Fang, DQ; Jiang, XW; Li, LJ; Li, YT; Peng, CG; Shi, D; Wang, Q; Wu, JJ; Wu, WR; Xia, PC; Yang, LY; Ye, JZ; Ye, WC | 1 |
| Hong, W; Li, M; Liu, L; Ren, H; Shi, X; Wang, J; Xu, H; Xu, Y | 1 |
| Kang, BS; Kwon, OS; Lee, DE; Lee, DS; Lee, HS; Lee, SJ; Nam, MJ; Park, JW | 1 |
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| Breitkopf-Heinlein, K; Ding, H; Dong, P; Dooley, S; Jiang, Q; Li, Q; Liu, B; Weng, H; Xu, K | 1 |
| Chen, D; Chen, Y; Choi, IC; Cui, G; Feng, Y; Lan, Q; Lee, SMY; Leung, GP; Ren, Z; Wang, T; Yan, F; Yang, B; Yu, HH | 1 |
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| He, J; Hu, B; Huang, M; Kelley, EE; Lu, P; Shi, X; Weidert, ER; Xie, W; Xu, M | 1 |
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| Chen, J; Chen, W; Deng, T; Lin, J; Qiu, L; Shi, D; Yang, J; Yang, JY; Ying, M | 1 |
| Asahara, T; Asano, T; Chonan, O; Fujishiro, M; Fukushima, T; Iwashita, M; Kamata, H; Kushiyama, A; Matsunaga, Y; Nakatsu, Y; Nishimura, F; Okubo, H; Sakoda, H; Yoshida, Y | 1 |
| Aleksić, V; Cerović, I; Jorgačević, B; Mladenović, D; Ninković, M; Prokić, V; Radosavljević, T; Stanković, M; Stanković, MN; Vučević, D; Vukićević, RJ | 1 |
| Blomme, E; Cherrington, NJ; Clarke, JD; Lake, AD; Maher, J; Sharapova, T | 1 |
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| Rezazadeh, A; Yazdanparast, R | 1 |
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| Claudel, T; Hoefler, G; Jha, P; Knopf, A; Koefeler, H; Lackner, C; Mueller, M; Trauner, M | 1 |
| Cherrington, NJ; Clarke, JD; Goedken, MJ; Hardwick, RN; Klaassen, CD; Lake, AD; Lickteig, AJ | 1 |
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| Csak, T; Dolganiuc, A; Ganz, M; Kodys, K; Kurt-Jones, EA; Lippai, D; Park, JK; Petrasek, J; Pillai, A; Szabo, G | 1 |
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| Chen, T; Hong, YM; Qiu, LX; Su, WJ; Zhong, FJ; Zhuang, LL | 1 |
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| Barghash, A; Bohle, RM; Cadenas, C; Gemperlein, K; Gianmoena, K; Haybaeck, J; Helms, V; Hengstler, JG; Kessler, SM; Kiemer, AK; Lammert, F; Mueller, R; Pokorny, J; Simon, Y; van Rooijen, N; Zimmer, V | 1 |
| Chen, S; Gu, J; Ji, L; Liu, X; Peng, X; Shen, X; Wu, W; Xue, R; Zhang, S | 1 |
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| Cho, EJ; Jang, ES; Kim, CY; Kim, YJ; Kwak, MS; Lee, HS; Lee, JH; Yoon, JH; Yu, SJ | 1 |
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| Bohle, RM; Gemperlein, K; Haybaeck, J; Kessler, SM; Kiemer, AK; Müller, R; Simon, Y | 1 |
| Chang, CJ; Liou, SS; Liu, IM; Tzeng, TF | 1 |
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| Gonzalez, FJ; Krausz, KW; Patterson, AD; Smith, PB; Takahashi, S; Tanaka, N; Zhang, Y | 1 |
| Akimoto, T; Alam, MM; Goto, M; Haseba, T; Kitamura, H; Motohashi, H; Ota, N; Shimizu, A; Takano-Yamamoto, T; Yamamoto, M | 1 |
| Iqbal, W; Kang, JH; Kwon, OS; Lee, SJ | 1 |
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| Liu, Q; Shi, M; Wang, F; Yu, F; Yu, N | 1 |
| Chen, Y; Deng, Y; Ding, Y; Qian, K; Sun, X | 1 |
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| Cherrington, NJ; Clarke, JD; Dzierlenga, AL; Goedken, MJ; Li, H; Nelson, NR; Werts, S | 1 |
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| Gokturk, HS; Kebapcilar, L; Korkmaz, H; Schmidt, WE; Unler, GK | 1 |
| Grenert, JP; Maher, JJ; Pickens, MK; Pierce, AA; Siao, K | 1 |
| Bohnic, B; Boursier, J; de Almeida, TP; Diehl, AM; Guy, CD; Machado, MV; Michelotti, GA; Xie, G | 1 |
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| Ben Ya'acov, A; Ilan, Y; Khoury, T; Shabat, Y; Snir, R; Zolotarovya, L | 1 |
| Asano, T; Fujishiro, M; Fukushima, T; Iwai, K; Iwashita, M; Kamata, H; Kushiyama, A; Matsunaga, Y; Nakatsu, Y; Okubo, H; Sakoda, H; Takahashi, S; Tokunaga, F; Tsuchiya, Y; Yamamotoya, T | 1 |
| Afonso, MB; Borralho, P; Caridade, M; Carvalho, T; Castro, RE; Cortez-Pinto, H; Rodrigues, CM; Rodrigues, PM | 1 |
| Albano, E; Bozzola, C; Bruzzì, S; Jindal, A; Locatelli, I; Sutti, S; Vacchiano, M | 1 |
| Cazanave, S; Min, HK; Mirshahi, F; Pacana, T; Patel, V; Quinlivan, E; Sanyal, AJ; Verdianelli, A | 1 |
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| Choi, HJ; Jang, S; Jo, W; Kim, JK; Kim, KW; Lee, HJ; Ryu, JE; Son, WC; Woo, DC; Yu, ES | 1 |
| Deng, Y; Ji, G; Jiang, Z; Li, X; Wang, Y | 1 |
| Cheng, YJ; Liou, SS; Liu, IM; Tzeng, TF; Tzeng, YC | 1 |
| Chen, R; Gao, X; He, B; Liu, F; Song, S; Wang, Q | 1 |
| Chen, J; Fan, X; Gao, X; Zhou, L | 1 |
| Asahara, T; Asano, T; Chonan, O; Encinas, J; Fujishiro, M; Fukushima, T; Iizuka, M; Inaba, T; Kamata, H; Katagiri, H; Kushiyama, A; Nagamachi, A; Nakatsu, Y; Nishimura, F; Okubo, H; Sakoda, H; Taki, N; Yoshida, Y | 1 |
| Furuichi, Y; Kobayashi, Y; Kojima, M; Moriyasu, F; Nakamura, I; Ogawa, S; Oshiro, H; Sano, T; Sugimoto, K; Yoshida, K | 1 |
| Ahn, YS; Cha, SW; Han, SH; Kang, OH; Kim, SB; Kong, R; Kwon, DY; Lee, YS; Seo, YS | 1 |
| Cappelletti, M; Divanovic, S; Dong, C; Giles, DA; Huppert, SS; Iwakura, Y; Moreno-Fernandez, ME; Shanmukhappa, SK; Stankiewicz, TE | 1 |
| Cho, EH; Choi, DH; Lee, EH; Lee, S; Li, YH; Seo, SR | 1 |
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| Aljazi, MB; Atshaves, BP; Brock, JR; Fader, KA; Jones, AD; Lydic, TA; Najt, CP; Olenic, SD; Senthivinayagam, S | 1 |
| Cerović, IB; Ješić Vukićević, R; Jorgačević, BZ; Mladenović, DR; Radosavljević, TS; Stevanović, I; Vesković, MN; Vučević, DB | 1 |
| Choi, KC; Choi, SJ; Kim, B; Kim, JW; Lee, K; Lee, SH; Lim, CW; Park, S; Yun, H | 1 |
| Han, SI; Isaka, M; Iwasaki, H; Kikuchi, T; Kobayashi, K; Matsuzaka, T; Mizuno, S; Nakagawa, Y; Ohno, H; Oikawa, F; Osaki, Y; Satoh, A; Shimano, H; Sone, H; Suzuki, H; Takahashi, S; Takei, K; Yagishita, Y; Yahagi, N; Yamada, N; Yatoh, S | 1 |
| Hou, C; Huang, Y; Li, W; Li, X; Ma, F; Zhang, A; Zhang, L; Zhu, Y | 1 |
| Cho, HJ; Cho, SJ; Chong, S; Chung, SJ; Kang, IM; Kim, DD; Kim, SB; Lee, JI; Yoon, IS | 1 |
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| Cherrington, NJ; Clarke, JD; Dzierlenga, AL; Goedken, M; Klein, DM; Laho, T; Li, H; Micuda, S | 1 |
| Jung, YS; Kim, JD; Kim, SH; Kim, SN; Kwon, HJ; Lee, YH; Oh, JY | 1 |
| Cao, Y; Chen, C; Qi, R; Wang, Y; Xu, L; Zhang, Q | 1 |
| Duan, X; Liu, K; Liu, Z; Meng, Q; Sun, H; Sun, P; Sun, X; Wang, C; Yang, X | 1 |
| Cherrington, NJ; Clarke, JD; Dzierlenga, AL | 1 |
| Maher, JJ | 1 |
| Chiba, T; Itoh, T; Sato, Y; Suzuki, S; Umegaki, K | 1 |
| Kang, BS; Kang, JH; Kwon, OS; Lee, DE; Lee, DS; Lee, HS; Lee, SJ; Nam, MJ; Park, JW | 1 |
| Duan, XP; Huo, XK; Liu, KX; Liu, ZH; Meng, Q; Peng, JY; Sun, HJ; Sun, PY; Wang, CY | 1 |
| Ishioka, M; Minami, S; Miura, K; Ohnishi, H; Shimura, Y | 1 |
| Kim, HS; Kim, M; Nho, CW; Randy, A; Yoo, G | 1 |
| Asagiri, M; Hatano, E; Ikeno, Y; Iwaisako, K; Kasai, Y; Koyama, Y; Nishio, T; Okuda, Y; Okuno, M; Sakurai, T; Seo, S; Tanabe, K; Taura, K; Uemoto, S; Yamamoto, G; Yoshino, K | 1 |
| Buechler, C; Eisinger, K; Haberl, EM; Krautbauer, S; Neumann, M; Pohl, R; Rein-Fischboeck, L; Weiss, TS; Zimny, S | 1 |
| Bridges, D; Miller, DD; Narayanan, R; Ponnusamy, S; Thiyagarajan, T; Tran, QT | 1 |
| Gao, M; Li, CG; Li, CZ; Li, Y; Liu, MX; Ma, ZL; Miao, LL; Peng, C; Pu, MF; Qi, XM; Ren, J; Yan, H; Yu, CZ; Zhao, Y | 1 |
| Ahmed, RF; Amin, MM; Saleh, DO | 1 |
| Clahsen, T; Drescher, HK; Hornef, M; Kroy, DC; Noels, H; Sahin, H; Schippers, A; Streetz, KL; Trautwein, C; Wagner, N | 1 |
| Harada, S; Kim, KI; Kim, SK; Kim, SR; Miyagi, K; Morimoto, Y; Nakamoto, K; Obata, T; Tokuyama, S | 1 |
| An, W; Lv, F; Miao, D; Wang, Y; Wu, J | 1 |
| Harada, T; Imada, K; Kajikawa, S; Kawashima, A; Mizuguchi, K; Shimizu, Y; Takeuchi, T | 1 |
| Abdelmalek, MF; Adams, DH; Agboola, KM; Bhattacharya, SD; Chen, Y; Choi, SS; Diehl, AM; Guy, CD; Jung, Y; Karaca, GF; Kuo, PC; Liaskou, E; Malladi, P; Mi, Z; Michelotti, GA; Moylan, C; Omenetti, A; Oo, YH; Pereira, TA; Syn, WK; Teaberry, V; Whitington, PF; Zdanowicz, M | 1 |
| Horiguchi, N; Kakizaki, S; Mori, M; Takizawa, D; Tojima, H; Yamazaki, Y | 1 |
| Catalano, D; Csak, T; Dolganiuc, A; Hritz, I; Kurt-Jones, E; Levin, I; Lippai, D; Mandrekar, P; Petrasek, J; Szabo, G; Velayudham, A | 1 |
| Bennett, C; Dasarathy, S; Duenas, C; Edmison, J; Gruca, LL; Kalhan, SC; Lopez, R; Marczewski, S | 1 |
| Csak, T; Dolganiuc, A; Ganz, M; Kodys, K; Pespisa, J; Szabo, G | 1 |
| Clarke, CN; Edwards, MJ; Lentsch, AB; Schuster, R; Tevar, AD; Wang, J | 1 |
| Elias, M; Gardikiotes, K; Gottstein, J; Green, RM; Rinella, ME; Siddiqui, MS | 1 |
| Banasch, M; Ellrichmann, M; Goetze, O; Schmidt, WE; Tannapfel, A | 1 |
| Katsuya, T; Kiomy Osako, M; Koriyama, H; Kyutoku, M; Minobe, N; Miyake, T; Morishita, R; Moritani, T; Nakagami, F; Nakagami, H; Shimamura, M; Shimizu, H; Shimosato, T | 1 |
| Miyahara, T; Miyata, Y; Moriyasu, F | 1 |
| Cho, MS; Jang, JE; Jeon, BH; Koh, EH; Lee, KU; Leem, J; Park, HS; Park, IS; Woo, SH | 1 |
| Cho, WK; Choi, HS; Hahm, JS; Jang, KS; Jeon, HJ; Jun, DW; Jun, JH; Kim, HJ; Kwon, HJ; Lee, HL; Lee, KN; Lee, MH; Lee, OY; Yoon, BC | 1 |
| Brückner, S; Christ, B; Pelz, S; Stock, P | 1 |
| Canet, MJ; Cherrington, NJ; Fisher, CD; Hardwick, RN; Street, SM | 1 |
| Bauer, S; Buechler, C; Eisinger, K; Hellerbrand, C; Higuchi, A; Schäffler, A; Walsh, K; Walter, R; Wanninger, J; Weiss, TS | 1 |
| Bucchieri, F; Bugianesi, E; Galvano, F; Li Volti, G; Mangiameli, A; Marino Gammazza, A; Marino, A; Parola, M; Paternostro, C; Salamone, F; Tibullo, D | 1 |
| Gonzalez, FJ; Krausz, KW; Matsubara, T; Patterson, AD; Tanaka, N | 1 |
| Camporez, JP; Eisenbarth, SC; Elinav, E; Flavell, RA; Gordon, JI; Hao, L; Henao-Mejia, J; Hoffman, HM; Jin, C; Jurczak, MJ; Kau, AL; Mehal, WZ; Shulman, GI; Strowig, T; Thaiss, CA | 1 |
| Cha, BS; Chae, MK; Kang, ES; Lee, BW; Lee, HC; Park, SG; Song, SO | 1 |
| Catalán, V; Frühbeck, G; Gómez-Ambrosi, J; Oliver, J; Roca, P; Rodríguez, A; Rotellar, F; Salvador, J; Silva, C; Valentí, V; Valle, A | 1 |
| Kwada, N; Mu, YP; Ogawa, T | 1 |
| Barbagallo, I; Cappello, F; Galvano, F; Li Volti, G; Mangiameli, A; Salamone, F | 1 |
| Ebinuma, H; Hatsuse, K; Hibi, T; Hokari, R; Irie, R; Kanai, T; Kurihara, C; Mataki, N; Minamino, T; Miura, S; Nishiyama, K; Okada, Y; Oshikawa, T; Saito, H; Shimamura, K; Shimizu, I; Sugiyama, K; Suzuki, T; Teratani, T; Tomita, K; Yamamoto, J; Yokoyama, H; Yoshida, Y | 1 |
| Canet, MJ; Cherrington, NJ; Gandolfi, AJ; Hardwick, RN; Klimecki, WT; Kopplin, MJ; Lake, AD; Scheffer, GL | 1 |
| Hou, MC; Huang, YT; Lee, FY; Lee, SD; Lin, HC; Tsai, TH; Yang, YY | 1 |
| Barakat, HA; Hamza, AH | 1 |
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| Hahn, YS; Landes, SG; Nguyen, V; Novobrantseva, TI; Tosello-Trampont, AC | 1 |
| Davaatseren, M; Hur, HJ; Hwang, JT; Kim, HJ; Kim, MJ; Kim, MS; Kwon, DY; Park, JH; Sung, MJ; Yang, HJ | 1 |
| Carmeliet, P; Casteleyn, C; Colle, I; Coulon, S; Geerts, A; Heindryckx, F; Jonckx, B; Leclercq, I; Legry, V; Libbrecht, L; Olievier, K; Stassen, JM; Van Steenkiste, C; Van Vlierberghe, H | 1 |
| Hada, N; Ito, T; Katsume, A; Matsumoto, M; Sakamaki, Y; Shiga, T; Sudoh, M; Tanaka, C; Uno, A | 1 |
| Dettmer, K; Gronwald, W; Hellerbrand, C; Klein, MS; Oefner, PJ; Reinders, J; Reinders, Y; Stevens, AP; Thomas, A | 1 |
5 review(s) available for methionine and Fatty Liver, Nonalcoholic
| Article | Year |
|---|---|
A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Hepatocytes; Humans; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Transcriptome | 2022 |
Methionine cycle in nonalcoholic fatty liver disease and its potential applications.
Topics: Biomarkers; Humans; Liver; Methionine; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction | 2022 |
Stratifying Non-alcoholic Steatohepatitis With the Non-invasive Ultrasound Markers Shear Wave Dispersion Slope and Shear Wave Velocity: An Animal Study.
Topics: Animals; Biomarkers; Choline; Fibrosis; Liver; Liver Cirrhosis; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; ROC Curve | 2022 |
One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics.
Topics: Animals; Betaine; Carbon; Choline; Disease Progression; Female; Folic Acid; Gastrointestinal Microbiome; Genome-Wide Association Study; Humans; Lipid Metabolism; Liver; Methionine; Microbiota; Models, Genetic; Non-alcoholic Fatty Liver Disease; Nutrients; Polymorphism, Single Nucleotide; Pregnancy; Prenatal Exposure Delayed Effects; Risk | 2020 |
Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights.
Topics: Animals; Choline Deficiency; Diet, Western; Disease Models, Animal; Humans; Methionine; Non-alcoholic Fatty Liver Disease | 2018 |
1 trial(s) available for methionine and Fatty Liver, Nonalcoholic
| Article | Year |
|---|---|
Four-Week Omega-3 Supplementation in Carriers of the Prosteatotic PNPLA3 p.I148M Genetic Variant: An Open-Label Study.
Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Dietary Supplements; Elasticity Imaging Techniques; Fatty Acids, Omega-3; Fatty Liver; Female; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Isoleucine; Lipase; Loss of Function Mutation; Male; Membrane Proteins; Methionine; Middle Aged; Non-alcoholic Fatty Liver Disease; Polymorphism, Single Nucleotide; Proteostasis; Time Factors; Young Adult | 2019 |
311 other study(ies) available for methionine and Fatty Liver, Nonalcoholic
| Article | Year |
|---|---|
Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis.
Topics: Animals; Choline Deficiency; Chylomicrons; Diet; Fatty Liver; Female; Fibrosis; Inflammation; Intestines; Male; Methionine; Mice; Mice, Knockout; Mice, Transgenic; Non-alcoholic Fatty Liver Disease | 2021 |
Zonarol Protected Liver from Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in a Mouse Model.
Topics: Animals; Biomarkers; Choline Deficiency; Diet; Disease Models, Animal; Hepatocytes; Immunohistochemistry; Lipid Metabolism; Liver; Male; Methionine; Mice; Models, Biological; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Protective Agents; Sesquiterpenes; Signal Transduction | 2021 |
Trans-anethole attenuates diet-induced nonalcoholic steatohepatitis through suppressing TGF-β-mediated fibrosis.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Choline; Diet; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Transforming Growth Factor beta | 2022 |
Notch-triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Endothelium; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Non-alcoholic Fatty Liver Disease | 2022 |
SU5, a new Auraptene analog with improved metabolic stability, ameliorates nonalcoholic fatty liver disease in methionine- and choline-deficient diet-fed db/db mice.
Topics: Animals; Choline; Coumarins; Diet; Disease Models, Animal; Down-Regulation; Half-Life; Humans; Lipid Metabolism; Liver; Methionine; Mice; Mice, Obese; Non-alcoholic Fatty Liver Disease; Rats; Receptors, Cytoplasmic and Nuclear; Tumor Necrosis Factor-alpha; Up-Regulation | 2022 |
Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.
Topics: Animals; Choline; Diet, High-Fat; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Galectin 3; Gene Expression Profiling; Lipid Droplets; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Sus scrofa | 2022 |
Water Specific MRI T1 Mapping for Evaluating Liver Inflammation Activity Grades in Rats With Methionine-Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease.
Topics: Animals; Area Under Curve; Biopsy; Choline; Diet; Inflammation; Liver; Magnetic Resonance Imaging; Male; Methionine; Non-alcoholic Fatty Liver Disease; Prospective Studies; Protons; Racemethionine; Rats; Water | 2022 |
HPS protects the liver against steatosis, cell death, inflammation, and fibrosis in mice with steatohepatitis.
Topics: Animals; Apoptosis; Diet, High-Fat; Disease Models, Animal; Humans; Inflammation; Insulin Resistance; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease | 2022 |
The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression.
Topics: Animals; Annexin A2; Hepatocytes; Humans; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Osteopontin | 2022 |
Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Biomarkers; Catalase; Choline; Choline Deficiency; Diet; DNA Damage; Glutathione Peroxidase; Inflammation; Liver; Melatonin; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Superoxide Dismutase; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2022 |
L-Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis, and inflammation in rats.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Fibrosis; Fructose; Inflammation; Lipid Metabolism; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; Sirtuin 1 | 2022 |
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis.
Topics: Animals; Annexin A1; Disease Models, Animal; Fibrosis; Inflammation; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism.
Topics: Animals; Chlorogenic Acid; Choline; Choline Deficiency; Diet; Endothelial Cells; HMGB1 Protein; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Livogrit Prevents Methionine-Cystine Deficiency Induced Nonalcoholic Steatohepatitis by Modulation of Steatosis and Oxidative Stress in Human Hepatocyte-Derived Spheroid and in Primary Rat Hepatocytes.
Topics: Animals; Cystine; Hepatocytes; Humans; Methionine; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Reactive Oxygen Species | 2022 |
AGK regulates the progression to NASH by affecting mitochondria complex I function.
Topics: Animals; Choline; Electron Transport Complex I; Liver; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; NADH Dehydrogenase; Non-alcoholic Fatty Liver Disease; Phosphotransferases (Alcohol Group Acceptor) | 2022 |
The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drugs, Chinese Herbal; Fibrosis; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease | 2022 |
Indole supplementation ameliorates MCD-induced NASH in mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; Indoles; Inflammation; Lipopolysaccharides; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Danhe granule ameliorates nonalcoholic steatohepatitis and fibrosis in rats by inhibiting ceramide de novo synthesis related to CerS6 and CerK.
Topics: Animals; Anti-Inflammatory Agents; Ceramides; Fibrosis; Interleukin-6; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine N-Acyltransferase; Tandem Mass Spectrometry; Transforming Growth Factor beta; Triglycerides; Tumor Necrosis Factor-alpha | 2022 |
The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis.
Topics: Animals; Chemokine CCL3; Chemokines; Choline; Gastrointestinal Microbiome; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Polysaccharides; Receptors, CCR1; RNA, Ribosomal, 16S; Wolfiporia | 2022 |
Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress.
Topics: Animals; Choline; Cytoplasmic Dyneins; Diet; Disease Models, Animal; Dyneins; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2022 |
MCD Diet Rat Model Induces Alterations in Zinc and Iron during NAFLD Progression from Steatosis to Steatohepatitis.
Topics: Animals; Choline; Diet; Fatty Acids; Iron; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Zinc | 2022 |
Maternal One-Carbon Supplement Reduced the Risk of Non-Alcoholic Fatty Liver Disease in Male Offspring.
Topics: Animals; Carbon; Diet, High-Fat; Dietary Supplements; Epigenesis, Genetic; Female; Humans; Liver; Male; Maternal Nutritional Physiological Phenomena; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Prenatal Exposure Delayed Effects | 2022 |
Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway.
Topics: 4-Butyrolactone; Animals; Fibrosis; Inflammation; Lipopolysaccharides; Liver; Methionine; Mice; Mice, Inbred C57BL; Monosaccharides; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Signal Transduction; Transforming Growth Factor beta1 | 2022 |
Vitamin B
Topics: Animals; Fatty Acids; Fibrosis; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Qa-SNARE Proteins; Vitamin B 12; Vitamins | 2022 |
High dietary methionine intake may contribute to the risk of nonalcoholic fatty liver disease by inhibiting hepatic H
Topics: Animals; Diet; Hydrogen Sulfide; Hypercholesterolemia; Lipids; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Integrating network pharmacology and in vivo experimental validation to reveal the alleviation of mailuoning oral liquid on non-alcoholic fatty liver disease.
Topics: Animals; Drugs, Chinese Herbal; Lipids; Liver; Methionine; Mice; Network Pharmacology; Non-alcoholic Fatty Liver Disease; PPAR alpha | 2022 |
FOSL2 deficiency delays nonalcoholic steatohepatitis progression by regulating LY6D-mediated NLRP3 activation.
Topics: Animals; Antigens, Ly; Choline; GPI-Linked Proteins; Lipopolysaccharides; Liver; Methionine; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Transcription Factors | 2022 |
A comparative study on roles of natural killer T cells in two diet-induced non-alcoholic steatohepatitis-related fibrosis in mice.
Topics: Animals; Diet; Fibrosis; Humans; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Non-alcoholic Fatty Liver Disease; RNA, Messenger | 2022 |
Exploring the Therapeutic Effects of Black Ginseng on Non-Alcoholic Fatty Liver Disease by Using Network Pharmacology and Molecular Docking.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Ginsenosides; Liver; Methionine; Mice; Molecular Docking Simulation; Network Pharmacology; Non-alcoholic Fatty Liver Disease; Panax; Proto-Oncogene Proteins c-akt | 2022 |
Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate experimental non-alcoholic steatohepatitis via Nrf2/NQO-1 pathway.
Topics: Animals; Antioxidants; Cholesterol; Culture Media, Conditioned; Cytochrome P-450 CYP2E1; Exosomes; Fatty Acid-Binding Proteins; Humans; Interleukin-6; Male; Mesenchymal Stem Cells; Methionine; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Palmitic Acid; Peroxisome Proliferator-Activated Receptors; Reactive Oxygen Species; Sterol Regulatory Element Binding Protein 1; Superoxide Dismutase; Tumor Necrosis Factor-alpha; Umbilical Cord | 2022 |
Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis.
Topics: Animals; Betulinic Acid; Bile Acids and Salts; Ceramides; Fibrosis; Glucose; Inflammasomes; Inflammation; Islet Amyloid Polypeptide; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Pentacyclic Triterpenes; Receptors, Cytoplasmic and Nuclear | 2022 |
Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Choline; Diet; Dipeptides; Fatty Acids; Glutathione Peroxidase; Inflammation; Lactate Dehydrogenases; Lipids; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Racemethionine; Superoxide Dismutase | 2022 |
Deleting Gata4 in hepatocytes promoted the progression of NAFLD via increasing steatosis and apoptosis, and desensitizing insulin signaling.
Topics: Animals; Apoptosis; Choline; Diet, High-Fat; GATA4 Transcription Factor; Hepatocytes; Insulin; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease | 2023 |
CCN6 improves hepatic steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis.
Topics: Animals; CCN Intercellular Signaling Proteins; Diet; Disease Models, Animal; Humans; Inflammation; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Regulation of the macrophage-hepatic stellate cell interaction by targeting macrophage peroxisome proliferator-activated receptor gamma to prevent non-alcoholic steatohepatitis progression in mice.
Topics: Animals; Culture Media, Conditioned; Hepatic Stellate Cells; Inflammation; Liver; Liver Cirrhosis; Macrophages; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; PPAR gamma | 2022 |
Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis.
Topics: Animals; Choline; Diet; Disease Models, Animal; Humans; Inflammation; Lipids; Liver; Liver Cirrhosis; Melatonin; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
P38γ modulates the lipid metabolism in non-alcoholic fatty liver disease by regulating the JAK-STAT signaling pathway.
Topics: Animals; Diet, High-Fat; Fatty Acids, Nonesterified; Inflammation; Janus Kinases; Leukemia, Myeloid, Acute; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Signal Transduction | 2023 |
Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation.
Topics: Animals; Choline; Disease Models, Animal; Intestines; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Gut microbiota and bile acids partially mediate the improvement of fibroblast growth factor 21 on methionine-choline-deficient diet-induced non-alcoholic fatty liver disease mice.
Topics: Animals; Bile Acids and Salts; Choline; Diet; Dysbiosis; Gastrointestinal Microbiome; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Low-Dose Administration of Cannabigerol Attenuates Inflammation and Fibrosis Associated with Methionine/Choline Deficient Diet-Induced NASH Model via Modulation of Cannabinoid Receptor.
Topics: Animals; Body Weight; Choline; Choline Deficiency; Diet; Fibrosis; Humans; Inflammation; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Racemethionine; Receptors, Cannabinoid | 2022 |
Extraction, characterization, and anti-nonalcoholic steatohepatitis activity of a (1,3) (1,6)-β-D-glucan from the Polyporus umbellatus (Pers.) Fries.
Topics: Animals; Choline; Diet; Glucans; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Polyporus | 2023 |
(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet-Induced Hepatic Steatosis.
Topics: Animals; Choline; Diet, High-Fat; Fibrosis; Lipids; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Prorenin Receptor; Triglycerides | 2023 |
Lower adiposity does not protect beta-2 syntrophin null mice from hepatic steatosis and inflammation in experimental non-alcoholic steatohepatitis.
Topics: Adiposity; Animals; Cholesterol Esters; Choline; Disease Models, Animal; Fatty Acid Synthases; Fatty Acids; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Obesity | 2023 |
Fructooligosaccharides attenuate non-alcoholic fatty liver disease by remodeling gut microbiota and association with lipid metabolism.
Topics: Animals; Choline; Diet, High-Fat; Gastrointestinal Microbiome; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Theabrownin ameliorates liver inflammation, oxidative stress, and fibrosis in MCD diet-fed C57BL/6J mice.
Topics: Animals; Choline; Choline Deficiency; Diabetes Mellitus, Type 2; Diet; Fibrosis; Inflammation; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Racemethionine; Tea | 2023 |
Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.
Topics: Animals; Choline; Diet; Drugs, Chinese Herbal; Endotoxemia; Gastrointestinal Microbiome; Inflammation; Lipopolysaccharides; Methionine; Mice; NF-kappa B; Non-alcoholic Fatty Liver Disease; Racemethionine; RNA, Ribosomal, 16S; Signal Transduction; Tight Junctions; Toll-Like Receptor 4 | 2022 |
Baicalein alleviates non-alcoholic fatty liver disease in mice by ameliorating intestinal barrier dysfunction.
Topics: Animals; Choline; Flavanones; Gastrointestinal Diseases; Intestinal Diseases; Liver; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease | 2023 |
Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Dual-Specificity Phosphatases; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Non-alcoholic Fatty Liver Disease; Osteoprotegerin; Racemethionine | 2023 |
[Adoptive bone marrow cells can reduce the liver injury of metabolic-dysfunction-associated fatty liver disease in mice by differentiating into natural killer T (NKT) cells and increasing their own lipid content].
Topics: Animals; Bone Marrow Cells; Interleukin-4; Killer Cells, Natural; Lipids; Methionine; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Non-alcoholic Fatty Liver Disease; Racemethionine | 2023 |
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Choline; Disease Models, Animal; Housing; Inflammation; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Hyperhomocysteinemia activates NLRP3 inflammasome to cause hepatic steatosis and insulin resistance via MDM2-mediated ubiquitination of HSF1.
Topics: Animals; Heat Shock Transcription Factors; Hyperhomocysteinemia; Inflammasomes; Insulin Resistance; Liver; Methionine; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Ubiquitination | 2023 |
Chrysin and its nanoliposome ameliorated non-alcoholic steatohepatitis via inhibiting TLR4 signalling pathway.
Topics: Animals; Choline; Diet; Disease Models, Animal; Flavonoids; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Toll-Like Receptor 4 | 2023 |
MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats.
Topics: Animals; Choline; Diet; Disease Models, Animal; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Racemethionine; Rats; Rats, Wistar | 2023 |
Endothelial autophagy is not required for liver regeneration after partial hepatectomy in mice with fatty liver.
Topics: Animals; Autophagy; Choline; Diet, High-Fat; Disease Models, Animal; Endothelial Cells; Focal Nodular Hyperplasia; Hepatectomy; Liver; Liver Regeneration; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice.
Topics: Animals; Choline; Disease Models, Animal; Inflammation; Isotope Labeling; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proteomics | 2023 |
Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fibrosis; Interleukin-8; Liver; Liver Cirrhosis; Liver Neoplasms; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Icariin Supplementation Suppresses the Markers of Ferroptosis and Attenuates the Progression of Nonalcoholic Steatohepatitis in Mice Fed a Methionine Choline-Deficient Diet.
Topics: Animals; Choline; Choline Deficiency; Diet; Dietary Supplements; Ferroptosis; Flavonoids; Liver; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Racemethionine | 2023 |
Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice.
Topics: Animals; Bile Acids and Salts; Caulobacteraceae; Choline Deficiency; Diet; Firmicutes; Gastrointestinal Microbiome; Lipids; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Racemethionine; RNA, Messenger | 2023 |
Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Choline; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Humans; Inflammasomes; Intracellular Signaling Peptides and Proteins; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2023 |
CARD9 deficiency aggravated nonalcoholic steatohepatitis in mice through increasing inflammatory response.
Topics: Animals; Choline; Diet, High-Fat; Disease Models, Animal; Liver Cirrhosis; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2024 |
Deletion of hepatic small heterodimer partner ameliorates development of nonalcoholic steatohepatitis in mice.
Topics: Animals; Cholesterol; Choline; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Protein Tyrosine Phosphatase, Non-Receptor Type 6 | 2023 |
Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating L-arginine production.
Topics: Animals; Choline; Diet, High-Fat; Disease Models, Animal; Hepatitis; Humans; Inflammation; Lactobacillus plantarum; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Study of Methionine Choline Deficient Diet-Induced Steatosis in Mice Using Endogenous Fluorescence Spectroscopy.
Topics: Adipose Tissue; Animals; Area Under Curve; Choline Deficiency; Discriminant Analysis; Disease Models, Animal; Disease Progression; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Principal Component Analysis; ROC Curve; Sensitivity and Specificity; Severity of Illness Index; Spectrometry, Fluorescence | 2019 |
Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease.
Topics: Adipokines; Animals; Body Weight; Cerium; Cholesterol; Choline; Diet; Fatty Acids; Gene Expression Regulation; Inflammation; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Nanoparticles; Non-alcoholic Fatty Liver Disease; Organ Size; Oxidative Stress; Rats, Wistar; Signal Transduction; Triglycerides | 2019 |
Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities.
Topics: Actins; Animal Experimentation; Animals; Calcium-Binding Proteins; Ceramides; Cholesterol; Choline Deficiency; Diet; Disease Models, Animal; Gene Expression Regulation; Interleukin-6; Liver; Lysophosphatidylcholines; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Receptors, G-Protein-Coupled; Sphingomyelins; Transforming Growth Factor beta; Triglycerides | 2019 |
L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet.
Topics: Animals; Carnitine; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; Disease Progression; Heart Diseases; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Reactive Oxygen Species | 2020 |
Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation-Mediated Cell Death in Mice.
Topics: Animals; Apoptosis; Cell Death; Choline Deficiency; Diet; Disease Progression; Ferroptosis; Inflammation; Lipid Peroxidation; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phospholipid Hydroperoxide Glutathione Peroxidase | 2020 |
Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.
Topics: Animals; Antagomirs; beta Catenin; Choline; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Humans; Low Density Lipoprotein Receptor-Related Protein-6; Methionine; Mice; MicroRNAs; Non-alcoholic Fatty Liver Disease; Wnt Signaling Pathway | 2019 |
Cigarette smoking differentially regulates inflammatory responses in a mouse model of nonalcoholic steatohepatitis depending on exposure time point.
Topics: Animals; Body Weight; Choline Deficiency; Cigarette Smoking; Cytokines; Diet, High-Fat; Disease Progression; Inflammation; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; Mice, Inbred C57BL; Monocytes; Non-alcoholic Fatty Liver Disease; Organ Size; PPAR gamma; Time Factors | 2020 |
Downregulation of GNAI3 Promotes the Pathogenesis of Methionine/Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease.
Topics: Animals; Choline; Disease Models, Animal; Down-Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Choline Deficiency; Curcumin; Disease Models, Animal; Endoplasmic Reticulum Stress; Glycosylation; Hexosamines; Inflammation Mediators; Liver; Male; Methionine; Mice, Inbred C57BL; N-Acetylglucosaminyltransferases; NF-kappa B; Non-alcoholic Fatty Liver Disease; Signal Transduction; Sirtuin 1; Superoxide Dismutase-1 | 2019 |
Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis.
Topics: Animals; Choline Deficiency; Collagen Type I; Cyclophilins; Diet; Disease Models, Animal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Male; Methionine; Mice; Molecular Targeted Therapy; Non-alcoholic Fatty Liver Disease | 2019 |
Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet.
Topics: Animals; Choline; Diet; Disease Models, Animal; Hepatectomy; Lipid Metabolism; Liver; Liver Neoplasms; Male; Metabolomics; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
Multi-technique comparison of atherogenic and MCD NASH models highlights changes in sphingolipid metabolism.
Topics: Animals; Atherosclerosis; Choline; Diet; Diet, Atherogenic; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Lipidomics; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Phosphatidylcholines; Sphingolipids | 2019 |
Hepatic NK cells attenuate fibrosis progression of non-alcoholic steatohepatitis in dependent of CXCL10-mediated recruitment.
Topics: Animals; Choline Deficiency; Fibrosis; Killer Cells, Natural; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation.
Topics: Adult; Animals; beta-Arrestin 1; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Disease Progression; Female; Golgi Apparatus; Growth Differentiation Factor 15; Humans; Lipogenesis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Non-alcoholic Fatty Liver Disease; Signal Transduction; Young Adult | 2020 |
Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice.
Topics: Animals; Choline Deficiency; Cytokines; Diet; Drug Liberation; Flavonoids; Liposomes; Liver; Male; Methionine; Mice, Inbred C57BL; Nanoparticles; Non-alcoholic Fatty Liver Disease; Toll-Like Receptor 4 | 2020 |
Role of hepatic neuropeptide Y-Y1 receptors in a methionine-choline-deficient model of non-alcoholic steatohepatitis.
Topics: Animals; Blotting, Western; Choline Deficiency; Disease Models, Animal; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Receptors, Neuropeptide Y; Triglycerides | 2020 |
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly.
Topics: Adult; Animals; Choline; Disease Models, Animal; Female; Glutaminase; Hepatocytes; Humans; Lipid Metabolism; Lipoproteins, VLDL; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phospholipids; Triglycerides | 2020 |
Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis.
Topics: Animal Feed; Animals; Body Weight; Choline; Diet; Disease Models, Animal; Female; Hepatic Stellate Cells; Humans; Inflammation; Insulin Resistance; Liver; Liver Cirrhosis; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphorylation; Placenta; Placental Extracts; Pregnancy; Reactive Oxygen Species; Smad Proteins | 2020 |
Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity.
Topics: Animals; Choline; Choline Deficiency; Diet; Ferroptosis; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4α-dependent very low-density lipoprotein.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Flavonoids; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Lipoproteins, VLDL; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Protein Kinase C; Secretory Pathway; Signal Transduction; Treatment Outcome | 2020 |
Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Gene Expression; Gene Knockout Techniques; Glucagon-Like Peptide 1; Inflammation; Intestinal Mucosa; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Permeability; Protein Tyrosine Phosphatase, Non-Receptor Type 1; RAW 264.7 Cells | 2020 |
Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice.
Topics: Animals; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Non-alcoholic Fatty Liver Disease | 2020 |
Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome.
Topics: Animals; Caspase 1; Choline; Diet; Disease Models, Animal; DNA, Mitochondrial; Gene Expression Regulation; Injections, Intraperitoneal; Interleukin-1beta; Iridoid Glucosides; Liver; Macrophages; Methionine; Mice; Mitochondria, Liver; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Treatment Outcome | 2020 |
The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates.
Topics: Animals; Body Weight; Cell Line; Choline; Fibroblast Growth Factors; Fibrosis; Inflammation; Liver; Macaca fascicularis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Primates; Rats; Signal Transduction | 2020 |
CREBH knockout accelerates hepatic fibrosis in mouse models of diet-induced nonalcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Choline Deficiency; Cyclic AMP Response Element-Binding Protein; Diet, High-Fat; Fibroblast Growth Factors; Hydroxyproline; Lipids; Liver Cirrhosis; Male; Methionine; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Signal Transduction; Transforming Growth Factor beta | 2020 |
Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH.
Topics: Adenylate Kinase; Animals; Antioxidants; Apoptosis; Cell Proliferation; Ceramides; Choline; Diet; Diglycerides; Energy Metabolism; Fatty Liver; Feeding Behavior; Hematopoietic Stem Cells; Homeostasis; Humans; Lipidomics; Liposomes; Male; Methionine; Mice, Inbred BALB C; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Phosphatidylcholines; Phosphorylation; Protein Subunits; Signal Transduction | 2020 |
Resveratrol prevents liver damage in MCD-induced steatohepatitis mice by promoting SIGIRR gene transcription.
Topics: Alanine Transaminase; Animals; Antioxidants; Choline Deficiency; Disease Models, Animal; Hepatocytes; Humans; Interleukin-1beta; Interleukin-6; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Receptors, Interleukin-1; Resveratrol; Toll-Like Receptors; Transcription, Genetic; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2020 |
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.
Topics: Animals; Arachidonate 12-Lipoxygenase; Choline; Choline Deficiency; Diet; Disease Models, Animal; Hepatic Stellate Cells; Isoenzymes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
Citrus reticulata Blanco peel extract ameliorates hepatic steatosis, oxidative stress and inflammation in HF and MCD diet-induced NASH C57BL/6 J mice.
Topics: Animals; Choline; Citrus; Diet, High-Fat; Disease Models, Animal; Fruit; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-E2 Transcription Factor; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Plant Extracts | 2020 |
MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Cells, Cultured; Choline; Circadian Rhythm; Diet; Disease Models, Animal; Early Growth Response Transcription Factors; Fibrosis; Hepatocytes; Kruppel-Like Transcription Factors; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2020 |
The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet.
Topics: Animals; Choline; Diet; Glucagon-Like Peptide-1 Receptor; Inflammation; Liraglutide; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2021 |
HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Choline Deficiency; Inflammation Mediators; Lipid Metabolism; Lipogenesis; Lipolysis; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Signal Transduction | 2020 |
Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD.
Topics: Animals; Betaine; Choline; Collagen; Diet; Dietary Supplements; Disease Models, Animal; Hepatocytes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
A Lipid-Based Nanocarrier Containing Active Vitamin D
Topics: Administration, Oral; Animals; Caco-2 Cells; Calcitriol; Cell Culture Techniques; Coculture Techniques; Disease Models, Animal; Drug Carriers; Gastrointestinal Microbiome; Hepatitis; Humans; Hypercalcemia; Intestinal Mucosa; Lipids; Lipopolysaccharides; Liver; Male; Methionine; Mice; Nanoparticles; Non-alcoholic Fatty Liver Disease; Pathogen-Associated Molecular Pattern Molecules; Permeability; RAW 264.7 Cells | 2020 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice.
Topics: Adenosylhomocysteinase; Animals; Betaine-Homocysteine S-Methyltransferase; Carbon; Disease Progression; Fibrosis; Folic Acid; Glycine N-Methyltransferase; Liver; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Polychlorinated Dibenzodioxins | 2020 |
Automated thermal imaging for the detection of fatty liver disease.
Topics: Algorithms; Animals; Automation; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Female; Humans; Image Processing, Computer-Assisted; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Thermography; Ultrasonography | 2020 |
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis
Topics: AMP-Activated Protein Kinases; Animals; Cholic Acids; Disease Models, Animal; Glucose; Homeostasis; Humans; Lipid Metabolism; Lipids; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; TOR Serine-Threonine Kinases | 2020 |
Live Confocal Imaging as a Novel Tool to Assess Liver Quality: Insights From a Murine Model.
Topics: Animals; Biopsy; Choline Deficiency; Cold Ischemia; Disease Models, Animal; Fatty Liver, Alcoholic; Liver; Male; Methionine; Mice, Inbred C57BL; Microscopy, Confocal; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; Reperfusion; Reperfusion Injury; Time Factors; Tissue Survival; Warm Ischemia | 2020 |
Plasma lipoprotein profile from nonalcoholic steatohepatitis model rats.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Choline Deficiency; Chylomicrons; Diet; Disease Models, Animal; Eating; Insulin; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Particle Size; Rats; Rats, Sprague-Dawley; Triglycerides | 2020 |
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Deficiency; Diethylnitrosamine; Disease Models, Animal; Humans; Lipidomics; Lipids; Lipogenesis; Liver; Liver Cirrhosis; Liver Neoplasms; Lysophosphatidylcholines; Male; Mass Spectrometry; Methionine; Mice; Mice, Inbred C3H; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2020 |
Associations between serum trace elements and inflammation in two animal models of nonalcoholic fatty liver disease.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Rats, Zucker; Trace Elements | 2020 |
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.
Topics: Amino Acids; Animal Feed; Animals; Apoptosis; Body Weight; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Humans; Inflammation; Insulin-Like Growth Factor I; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Organ Size; Phosphorylation; RNA; Soybean Oil; Sulfotransferases; Trans Fatty Acids | 2020 |
Beneficial and deleterious effects of sitagliptin on a methionine/choline-deficient diet-induced steatohepatitis in rats.
Topics: Animals; Choline Deficiency; Diet; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Sitagliptin Phosphate | 2021 |
ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice.
Topics: Adipocytes; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Choline Deficiency; Chromatography, Liquid; Disease Models, Animal; Exosomes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Tandem Mass Spectrometry | 2021 |
Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress.
Topics: Animals; Autophagy; Kelch-Like ECH-Associated Protein 1; Liver; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Secosteroids | 2021 |
A Mineralocorticoid Receptor Deficiency in Myeloid Cells Reduces Liver Steatosis by Impairing Activation of CD8
Topics: Adaptive Immunity; Animals; CD8-Positive T-Lymphocytes; Choline Deficiency; Diet; Disease Models, Animal; Female; Hepatitis; Inflammation; Liver Cirrhosis; Lymphocyte Activation; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; Non-alcoholic Fatty Liver Disease; Receptors, Mineralocorticoid | 2020 |
Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase.
Topics: Administration, Oral; Aldehyde Oxidase; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Hydralazine; Lipid Droplets; Liver; Male; Methionine; Niacinamide; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; S-Adenosylmethionine; Triglycerides | 2021 |
Multiparametric ultrasound imaging for the assessment of normal versus steatotic livers.
Topics: Animals; Choline Deficiency; Elasticity Imaging Techniques; Food, Formulated; Liver; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2021 |
Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression.
Topics: Animals; Liver; Methionine; Mice; Mice, Inbred ICR; Nicotinamide N-Methyltransferase; Non-alcoholic Fatty Liver Disease; Thiamethoxam | 2021 |
Visfatin exacerbates hepatic inflammation and fibrosis in a methionine-choline-deficient diet mouse model.
Topics: Adipokines; Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Nicotinamide Phosphoribosyltransferase; Non-alcoholic Fatty Liver Disease | 2021 |
Therapeutic potential of puerarin against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis determined by combination of
Topics: Animals; Choline; Diet; Disease Models, Animal; Genes, rRNA; Isoflavones; Liver; Magnetic Resonance Spectroscopy; Metabolomics; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; RNA, Ribosomal, 16S | 2021 |
Ethyl pyruvate supplemented in drinking water ameliorates experimental nonalcoholic steatohepatitis.
Topics: Animals; Antioxidants; Bacterial Translocation; Diet; Drinking Water; Interleukin-6; Liver; Liver Function Tests; Male; Malondialdehyde; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Pyruvates; Tumor Necrosis Factor-alpha | 2021 |
SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH).
Topics: Animals; Anti-Inflammatory Agents; Choline; Cinnamates; Depsides; Disease Models, Animal; Liver; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Non-alcoholic Fatty Liver Disease; PPAR alpha; Rosmarinic Acid; Sirtuin 1 | 2022 |
BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization.
Topics: Adenoviridae; Animals; Cell Differentiation; Choline; Cytokines; Diet; Disease Models, Animal; Gene Expression Regulation; Genetic Vectors; Growth Differentiation Factor 2; Humans; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; NF-kappa B; Non-alcoholic Fatty Liver Disease; RAW 264.7 Cells; Th1 Cells | 2021 |
Hepatocyte-specific deletion of Nlrp6 in mice exacerbates the development of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Hepatocytes; Humans; Intracellular Signaling Peptides and Proteins; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Receptors, Cell Surface | 2021 |
Salvia-Nelumbinis naturalis extract protects mice against MCD diet-induced steatohepatitis via activation of colonic FXR-FGF15 pathway.
Topics: Animals; Choline Deficiency; Colon; Diet; Drugs, Chinese Herbal; Dysbiosis; Fibroblast Growth Factors; Gastrointestinal Microbiome; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Protective Agents; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2021 |
Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis.
Topics: Animals; Caspases, Initiator; Choline; Diet; Disease Progression; Hepatocytes; Inflammation; Lipopolysaccharides; Liver; Methionine; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Pyroptosis; Signal Transduction; Up-Regulation | 2021 |
Soyasaponin A
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Choline Deficiency; Colon; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Saponins | 2021 |
Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α.
Topics: Animals; Choline; Diet; Lipid Metabolism; Liver; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Oxazoles; PPAR alpha; Silybin; Tyrosine | 2021 |
The PKM2 activator TEPP-46 attenuates MCD feeding-induced nonalcoholic steatohepatitis by inhibiting the activation of Kupffer cells.
Topics: Animals; Choline; Cytokines; Diet; Inflammasomes; Kupffer Cells; Liver; Male; Methionine; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Pyridazines; Pyrroles; Pyruvate Kinase | 2021 |
Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation.
Topics: Animals; Cell Line, Tumor; Choline; Diet; Epithelial Cells; Feeding Behavior; Humans; Inflammation; Intestines; Macrophages; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phenotype; RAW 264.7 Cells; Weight Loss | 2021 |
[Parathyroid hormone-related protein aggravates nonalcoholic fatty liver disease induced by methionine choline-deficient diet in mice].
Topics: Animals; Choline; Diet; Disease Models, Animal; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Parathyroid Hormone-Related Protein | 2021 |
Network pharmacology-based identification of significant pathway for protection of Yinhuang granule in a mice model of metabolic-associated fatty liver disease.
Topics: Animals; Diet; Disease Models, Animal; Drugs, Chinese Herbal; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2021 |
Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis.
Topics: Animals; Carbamates; Histone Deacetylase Inhibitors; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Diet; Disease Models, Animal; Fast Foods; Leukocytes, Mononuclear; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphorylation; Protective Agents; Shc Signaling Adaptor Proteins; Signal Transduction; Therapeutics; Ubiquinone | 2021 |
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways.
Topics: Amino Acids; Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Signal Transduction | 2021 |
Homocysteine Induces Hepatic Steatosis Involving ER Stress Response in High Methionine Diet-Fed Mice.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cells, Cultured; Endoplasmic Reticulum Stress; Gene Expression Regulation; Hepatocytes; Homocysteine; Hyperhomocysteinemia; Lipogenesis; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Organ Size; Phenylbutyrates; Random Allocation; Tunicamycin | 2017 |
Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Gastrointestinal Microbiome; Gene Expression Profiling; Liver; Male; Maternal Nutritional Physiological Phenomena; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Overnutrition; Pregnancy; Prenatal Exposure Delayed Effects | 2017 |
Hyperpolarized
Topics: Animals; Ascorbic Acid; Carbon-13 Magnetic Resonance Spectroscopy; Choline Deficiency; Dehydroascorbic Acid; Diet; Disease Models, Animal; Lipid Metabolism; Liver; Magnetic Resonance Imaging; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2017 |
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Topics: Amino Acid Oxidoreductases; Animals; Cell Proliferation; Cell Transdifferentiation; Cells, Cultured; Choline Deficiency; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Induction; Extracellular Matrix; Forkhead Box Protein O1; Genetic Predisposition to Disease; Hepatic Stellate Cells; Hepatocytes; Humans; Insulin Resistance; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Phenotype; Receptor, Insulin; Signal Transduction | 2017 |
Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Intestines; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oligosaccharides; Prebiotics | 2017 |
Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.
Topics: Animals; Biomarkers; Choline Deficiency; Cytokine Receptor gp130; Dietary Supplements; Disease Models, Animal; Humans; Inflammation; Interleukin-6; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Non-alcoholic Fatty Liver Disease | 2017 |
Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Topics: Animals; Cell Cycle Proteins; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fatty Acid Transport Proteins; Fatty Acid-Binding Proteins; Fatty Acids; Glycerophospholipids; Hepatocytes; Male; Methionine; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Nuclear Proteins; Phosphatidate Phosphatase; Phospholipase D; RNA, Messenger; Transferases (Other Substituted Phosphate Groups); Transforming Growth Factor beta; Triglycerides; Tumor Necrosis Factor-alpha | 2017 |
Editor's Highlight: PCB126 Exposure Increases Risk for Peripheral Vascular Diseases in a Liver Injury Mouse Model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Disease Models, Animal; Energy Metabolism; Environmental Pollutants; Gene Expression Regulation; Inflammation Mediators; Liver; Liver Cirrhosis; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Peripheral Vascular Diseases; Polychlorinated Biphenyls | 2017 |
Role of ADAMTS13 in diet-induced liver steatosis.
Topics: ADAMTS13 Protein; Animals; Body Weight; CD36 Antigens; Choline Deficiency; Diet; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Tissue Inhibitor of Metalloproteinase-1; Triglycerides; von Willebrand Factor | 2017 |
Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool.
Topics: Animals; Antigens, Ly; Biomarkers; Cell Differentiation; Cell Proliferation; Choline; Female; Ki-67 Antigen; Kupffer Cells; Lectins, C-Type; Liver; Membrane Proteins; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2017 |
Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis.
Topics: Animals; Cells, Cultured; Choline; Diet; Epithelial Cell Adhesion Molecule; Fibroblast Growth Factors; Humans; Interleukin-1beta; Interleukin-6; Keratin-19; Liver; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Protein Tyrosine Phosphatase, Non-Receptor Type 1 | 2018 |
Asking the Right Questions With Animal Models: Methionine- and Choline-Deficient Model in Predicting Adverse Drug Reactions in Human NASH.
Topics: Animals; Biological Transport; Choline Deficiency; Cytochrome P-450 Enzyme System; Diet; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Humans; Methionine; Non-alcoholic Fatty Liver Disease; Pharmaceutical Preparations; Predictive Value of Tests; Tissue Distribution | 2018 |
Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Chemokine CCL2; Choline Deficiency; Diet; Flavonoids; Interleukin-1beta; Lipid Metabolism; Liver; Liver Cirrhosis; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2018 |
Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Clusterin; Diet; Disease Models, Animal; Hepatocytes; Liver; Male; Methionine; Mice; Mice, Transgenic; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; RNA, Messenger; Up-Regulation | 2018 |
Fatty acids in non-alcoholic steatohepatitis: Focus on pentadecanoic acid.
Topics: Animals; Choline; Choline Deficiency; Disease Models, Animal; Fatty Acids; Hepatocytes; Humans; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Triglycerides | 2017 |
Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model.
Topics: Adipocytes; Adiponectin; Adiposity; Animals; Body Weight; Calcium-Binding Proteins; Cell Size; Choline Deficiency; Diet, Atherogenic; Disease Models, Animal; Feeding Behavior; Inflammation; Lipase; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Membrane Proteins; Methionine; Mice; Mice, Knockout; Muscle Proteins; Muscle, Skeletal; Myostatin; Non-alcoholic Fatty Liver Disease; Organ Size; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Triglycerides | 2018 |
Butein protects the nonalcoholic fatty liver through mitochondrial reactive oxygen species attenuation in rats.
Topics: Administration, Oral; Albumins; Animals; Chalcones; Choline; Choline Deficiency; Diet; Globulins; Heme Oxygenase (Decyclizing); Hypolipidemic Agents; Liver; Male; Methionine; Mitochondria; Non-alcoholic Fatty Liver Disease; Peroxidase; Rats; Rats, Wistar; Reactive Oxygen Species; Transaminases | 2018 |
Chemerin in a Mouse Model of Non-alcoholic Steatohepatitis and Hepatocarcinogenesis.
Topics: Adiponectin; Animals; Body Composition; Chemokines; Choline Deficiency; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Intercellular Signaling Peptides and Proteins; Liver; Liver Neoplasms, Experimental; Male; Methionine; Mice; Mice, Inbred C3H; Neoplasm Proteins; Non-alcoholic Fatty Liver Disease; Protein Precursors; Receptors, G-Protein-Coupled | 2018 |
Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice.
Topics: Actins; Animals; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Diet; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation; Growth Differentiation Factor 15; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Osteopontin; Primary Cell Culture; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Transcription Factor CHOP; Transforming Growth Factor beta1 | 2018 |
Use of an animal model to test whether non-alcoholic fatty liver disease increases the risk of idiosyncratic drug-induced liver injury.
Topics: Amodiaquine; Animals; Antibodies, Blocking; Chemical and Drug Induced Liver Injury; Choline Deficiency; Disease Models, Animal; Female; Granzymes; Humans; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Programmed Cell Death 1 Receptor; Risk | 2018 |
Investigation of nonalcoholic fatty liver disease-induced drug metabolism by comparative global toxicoproteomics.
Topics: Animals; Choline Deficiency; Chromatography, Liquid; Computational Biology; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Interactions; Isoenzymes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proteomics; Risk Assessment; Substrate Specificity; Tandem Mass Spectrometry; Toxicology; Xenobiotics | 2018 |
Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mTOR pathway.
Topics: Adenylate Kinase; Animals; Autophagy; Cell Line; Cholestenones; Choline; Diet; Disease Models, Animal; Humans; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Hepatocyte-specific deletion of Brg1 alleviates methionine-and-choline-deficient diet (MCD) induced non-alcoholic steatohepatitis in mice.
Topics: Animals; Cells, Cultured; Choline Deficiency; Diet; DNA Helicases; Epigenesis, Genetic; Gene Deletion; Hepatocytes; Liver; Male; Methionine; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Nuclear Proteins; Transcription Factors; Up-Regulation | 2018 |
Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Dysbiosis; Feces; Gastrointestinal Microbiome; Humans; Intestines; Liver Cirrhosis; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; RNA, Ribosomal, 16S | 2018 |
A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; DNA Helicases; Epigenesis, Genetic; Gene Deletion; Hepatocytes; Histone Acetyltransferases; Methionine; Mice; NADPH Oxidases; Non-alcoholic Fatty Liver Disease; Nuclear Proteins; Promoter Regions, Genetic; Reactive Oxygen Species; Salicylates; Transcription Factors | 2019 |
Silibinin Ameliorates
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; beta-N-Acetylhexosaminidases; Choline Deficiency; Humans; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Peroxiredoxins; Proteomics; RAW 264.7 Cells; Silybin; Silymarin | 2018 |
Molybdate Attenuates Lipid Accumulation in the Livers of Mice Fed a Diet Deficient in Methionine and Choline.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Diet; Lipid Metabolism; Liver; Male; Malondialdehyde; Methionine; Mice, Inbred C57BL; Molybdenum; Non-alcoholic Fatty Liver Disease | 2018 |
Protective effect of isochlorogenic acid B on liver fibrosis in non-alcoholic steatohepatitis of mice.
Topics: Animals; Chlorogenic Acid; Cholesterol; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; MicroRNAs; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Random Allocation; Triglycerides | 2019 |
Gypenoside UL4-Rich Gynostemma pentaphyllum Extract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease.
Topics: Animals; Choline Deficiency; Dietary Supplements; Gynostemma; Hep G2 Cells; Humans; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phytotherapy; Plant Extracts; Sirtuins | 2018 |
Gamma-Tocotrienol Attenuates the Hepatic Inflammation and Fibrosis by Suppressing Endoplasmic Reticulum Stress in Mice.
Topics: Animals; Body Weight; Cholesterol; Chromans; Diet, Western; Dietary Supplements; Endoplasmic Reticulum Stress; Fibrosis; Hepatitis; Insulin Resistance; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Triglycerides; Vitamin E | 2018 |
Polyurethane Nanoparticle-Loaded Fenofibrate Exerts Inhibitory Effects on Nonalcoholic Fatty Liver Disease in Mice.
Topics: Animals; Drug Carriers; Fenofibrate; Hep G2 Cells; Humans; Hypolipidemic Agents; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Nanoparticles; Non-alcoholic Fatty Liver Disease; Polyurethanes | 2018 |
Effect of Phyllanthus emblica L. fruit on methionine and choline-deficiency diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Choline; Diet; Fruit; Humans; Interleukin-1beta; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phyllanthus emblica; Plant Extracts; Tumor Necrosis Factor-alpha | 2018 |
Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3/6 pathways in a methionine choline deficient diet steatohepatitis mouse model.
Topics: Animals; Antioxidants; Apoptosis; Choline; Diet; Disease Models, Animal; Drugs, Chinese Herbal; Female; Fibrosis; Liver; Male; Methionine; Mice; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Receptors, Cell Surface | 2018 |
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Choline Deficiency; Diet; Inflammation; Interleukin-1beta; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; S100 Calcium-Binding Protein A4; Triglycerides; Tumor Necrosis Factor-alpha | 2018 |
De novo NAD
Topics: Animals; Caenorhabditis elegans; Carboxy-Lyases; Cell Line; Choline; Conserved Sequence; Disease Models, Animal; Evolution, Molecular; Female; Gene Knockdown Techniques; Health; Hepatocytes; Homeostasis; Humans; Kidney; Liver; Longevity; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Non-alcoholic Fatty Liver Disease; Rats; Sirtuins | 2018 |
Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Cytokines; Diet, High-Fat; Disease Models, Animal; Inflammation; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Receptors, Nicotinic | 2019 |
Hepatic metabolomics reveals that liver injury increases PCB 126-induced oxidative stress and metabolic dysfunction.
Topics: Animals; Diet; Lipid Metabolism; Liver; Metabolomics; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Polychlorinated Biphenyls | 2019 |
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.
Topics: Animals; Choline; Diet; Female; Hepatic Stellate Cells; Hepatocytes; Humans; Liver Cirrhosis; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Osteopontin; Receptors, Notch; SOX9 Transcription Factor | 2018 |
Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development.
Topics: Animals; Choline Deficiency; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fatty Liver; Inflammation; Inflammation Mediators; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Schisandra | 2019 |
Dietary methionine restriction reduces hepatic steatosis and oxidative stress in high-fat-fed mice by promoting H
Topics: Animals; Cystathionine gamma-Lyase; Diet, High-Fat; Humans; Hydrogen Sulfide; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2019 |
Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway.
Topics: Adenylate Kinase; Animals; Choline Deficiency; Dose-Response Relationship, Drug; Gallic Acid; Hep G2 Cells; Humans; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Protective Agents; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2019 |
Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis.
Topics: Animals; Apoptosis; Calcium; Cholesterol; Choline; Diet; Disease Progression; Dynamins; Feeding Behavior; Fructose; Gene Deletion; GTP Phosphohydrolases; Hepatocytes; Humans; Inflammation; Lipolysis; Liver; Lysosomes; Macrophages, Peritoneal; Male; Mechanistic Target of Rapamycin Complex 1; Methionine; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Palmitates; Phagosomes; Phosphorylation; Phosphoserine; Regulatory-Associated Protein of mTOR | 2019 |
Administration of methyl palmitate prevents non-alcoholic steatohepatitis (NASH) by induction of PPAR-α.
Topics: Animals; Choline Deficiency; Hep G2 Cells; Humans; Lipid Peroxidation; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Palmitates; PPAR alpha | 2019 |
Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Microbiome; Genetic Variation; Humans; Inflammation; Liver Cirrhosis; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2019 |
Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease.
Topics: Animals; Autophagy; Betaine; Choline Deficiency; Gastrointestinal Agents; Inflammation; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes.
Topics: Animals; Choline Deficiency; Diet; Female; Gene Deletion; Group VI Phospholipases A2; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Phospholipids | 2019 |
Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Folate Receptor 2; Folic Acid; Humans; Liver; Macrophages; Male; Methionine; Mice, Inbred C57BL; Molecular Imaging; Non-alcoholic Fatty Liver Disease; Organotechnetium Compounds; Predictive Value of Tests; Radiopharmaceuticals; Rats, Sprague-Dawley; Tomography, Emission-Computed, Single-Photon | 2019 |
Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity.
Topics: Animals; Cell Adhesion Molecules; Cholesterol; Choline; Diet, High-Fat; Hepatobiliary Elimination; Inflammation; Kidney; Liver; Male; Marine Toxins; Methionine; Microcystins; Non-alcoholic Fatty Liver Disease; Organic Anion Transporters; Protein Phosphatase 2; Proteinuria; Rats, Sprague-Dawley; Toxicokinetics | 2019 |
Metabolic characterization of two different non-alcoholic fatty liver disease pre-clinical mouse models.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cholesterol; Choline; Diet, High-Fat; Disease Models, Animal; Fructose; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Random Allocation; Sweetening Agents | 2019 |
Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation.
Topics: Animals; Aryldialkylphosphatase; Autophagy; Chemokine CCL2; Diet, High-Fat; Energy Metabolism; Gene Expression Regulation; Glutathione; Hyperlipidemias; Lipoproteins, LDL; Liver; Lysosomal-Associated Membrane Protein 2; Macrophages; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Receptors, LDL; Signal Transduction | 2019 |
MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice.
Topics: Animals; Cells, Cultured; Choline Deficiency; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Hepatocytes; Interleukin-6; Male; Methionine; Mice; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Smad3 Protein; Transforming Growth Factor beta | 2019 |
Epoxyeicosatrienoic acids alleviate methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in mice.
Topics: Animals; Cell Line; Cell Line, Tumor; Chemokines; Choline; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Cytokines; Diet; Down-Regulation; Hep G2 Cells; Humans; Inflammation; Intercellular Adhesion Molecule-1; Liver; Macrophages; Methionine; Mice; NF-kappa B; Non-alcoholic Fatty Liver Disease; Phenylurea Compounds; Piperidines; PPAR alpha; RNA, Messenger; Signal Transduction; Sterol Regulatory Element Binding Protein 1; THP-1 Cells; Vascular Cell Adhesion Molecule-1 | 2019 |
Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model.
Topics: Animals; Antioxidants; Choline Deficiency; Endoplasmic Reticulum Stress; Glutathione Peroxidase; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Simvastatin; Superoxide Dismutase | 2019 |
Adenovirus‑mediated overexpression of bone morphogenetic protein‑9 promotes methionine choline deficiency‑induced non‑alcoholic steatohepatitis in non‑obese mice.
Topics: Adenoviridae; Animals; Choline Deficiency; Growth Differentiation Factor 2; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; RNA, Messenger; Up-Regulation | 2019 |
Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat.
Topics: Animals; Choline; Drugs, Chinese Herbal; Food, Formulated; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar | 2019 |
Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism.
Topics: Amino Acids; Animals; Betaine-Homocysteine S-Methyltransferase; Carbon; Cell Line, Tumor; Cystathionine beta-Synthase; Diet, High-Fat; Fatty Liver; Gene Expression Regulation, Enzymologic; Homeostasis; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphatidylcholines; PPAR alpha; Rats; Sequence Analysis, DNA | 2013 |
Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3.
Topics: Acetylation; Animals; Choline Deficiency; Fatty Liver; Food, Formulated; Gene Expression; Lipid Peroxidation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Polychlorinated Dibenzodioxins; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Sirtuin 3; Superoxide Dismutase | 2013 |
Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Endotoxemia; Fatty Liver; Female; Lipase; Lipopolysaccharides; Liver; Male; Methionine; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; PPAR alpha; Signal Transduction | 2014 |
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis.
Topics: Aldehyde Reductase; Animals; Blotting, Western; Choline; Diet; Fatty Liver; Female; Interleukin-6; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha | 2013 |
Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.
Topics: Animals; Bifidobacterium; Choline Deficiency; Disease Models, Animal; Fatty Liver; Gastrointestinal Tract; Gene Expression Profiling; Inflammation; Lacticaseibacillus casei; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Microbiota; Non-alcoholic Fatty Liver Disease | 2013 |
Dynamics of oxidative/nitrosative stress in mice with methionine-choline-deficient diet-induced nonalcoholic fatty liver disease.
Topics: Animals; Antioxidants; C-Reactive Protein; Catalase; Choline Deficiency; Disease Models, Animal; Ferritins; Glutathione; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Mice, Inbred C57BL; Nitrates; Nitrites; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Superoxide Dismutase; Time Factors | 2014 |
Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Disease Models, Animal; Early Diagnosis; Genetic Markers; Male; Methionine; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; Severity of Illness Index; Time Factors | 2014 |
Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice.
Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aspartate Aminotransferases; Biomarkers; Cell Proliferation; Chemokine CCL2; Choline Deficiency; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Kupffer Cells; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proliferating Cell Nuclear Antigen; RNA, Messenger; Time Factors | 2013 |
Dietary glycotoxins exacerbate progression of experimental fatty liver disease.
Topics: Animals; Cell Proliferation; Choline Deficiency; Diet; Disease Progression; Gene Expression; Glycation End Products, Advanced; Hepatic Stellate Cells; Insulin Resistance; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2014 |
The effects of α-lipoic acid on liver oxidative stress and free fatty acid composition in methionine-choline deficient diet-induced NAFLD.
Topics: Animals; Choline; Diet; Fatty Acids, Nonesterified; Fatty Liver; Humans; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Thioctic Acid | 2014 |
Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes.
Topics: Animals; Antioxidants; Ascorbic Acid; Chelating Agents; Choline; Diet; Ethylenediamines; Fatty Liver; Inflammation; Liver; Male; Manganese Compounds; Methionine; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats | 2014 |
Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis.
Topics: Animals; Apoptosis; Biomarkers; Cells, Cultured; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Enzyme Activation; Fatty Liver; Female; Gene Expression; Hepatocytes; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Primary Cell Culture; Protein Kinase C-delta | 2014 |
Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease.
Topics: Animals; Choline; Diet; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes; Lipids; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Risk Factors; Time Factors | 2014 |
Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).
Topics: Adipogenesis; Adipose Tissue; Animals; Choline; Disease Models, Animal; Fatty Acids; Fatty Acids, Nonesterified; Fatty Liver; Fibroblast Growth Factors; Inflammation; Lipase; Lipid Metabolism; Lipolysis; Liver; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Oxidation-Reduction | 2014 |
Synergistic interaction between genetics and disease on pravastatin disposition.
Topics: Animals; Biological Transport, Active; Choline; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver-Specific Organic Anion Transporter 1; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscles; Non-alcoholic Fatty Liver Disease; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Pravastatin | 2014 |
n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-6; Inflammation Mediators; Liver; Liver Cirrhosis; Male; Methionine; Mice, Inbred BALB C; Necrosis; Non-alcoholic Fatty Liver Disease; Olive Oil; Plant Oils; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2014 |
Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis.
Topics: Animals; Blotting, Western; Bone Marrow Cells; Carrier Proteins; Choline Deficiency; Diet; DNA-Binding Proteins; Gene Expression Regulation; Immunoprecipitation; Inflammasomes; Methionine; Mice; Mice, Knockout; Myeloid Differentiation Factor 88; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Signal Transduction; Statistics, Nonparametric; Toll-Like Receptor 4; Toll-Like Receptor 9 | 2014 |
Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice.
Topics: Animals; Annexin A1; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Hepatitis; Humans; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Obesity | 2014 |
Effect of Trifolium pratense extract on methionine-choline-deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Animals; Cholesterol; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phytotherapy; Plant Extracts; PPAR gamma; RNA, Messenger; Trifolium; Triglycerides | 2014 |
GH administration rescues fatty liver regeneration impairment by restoring GH/EGFR pathway deficiency.
Topics: Animals; Blotting, Western; Cell Proliferation; Choline; Diet; Down-Regulation; ErbB Receptors; Fatty Liver; Hepatectomy; Hepatocytes; Human Growth Hormone; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Obese; Non-alcoholic Fatty Liver Disease; Obesity; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Triglycerides | 2014 |
Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease Models, Animal; Fatty Acid Elongases; Fatty Acids; Humans; Inflammation; Liver Neoplasms; Methionine; Mice; Mice, Inbred DBA; Mice, Obese; Non-alcoholic Fatty Liver Disease; RNA, Messenger | 2014 |
Bile acids override steatosis in farnesoid X receptor deficient mice in a model of non-alcoholic steatohepatitis.
Topics: Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear | 2014 |
Caspase 3 inactivation protects against hepatic cell death and ameliorates fibrogenesis in a diet-induced NASH model.
Topics: Animals; Antigens, Ly; Apoptosis; Caspase 3; Choline; Collagen; Dose-Response Relationship, Drug; Fatty Liver; Gene Expression Regulation; Hepatic Stellate Cells; Hepatocytes; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Receptors, CCR2 | 2014 |
Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice.
Topics: Animals; Dietary Supplements; Female; Glutathione; Homocysteine; Lipid Metabolism; Liver; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Triglycerides | 2014 |
Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice.
Topics: Animals; Apoptosis; Caspase 8; Choline Deficiency; Diet; Hepatocyte Growth Factor; Hepatocytes; Inflammation; Lipotropic Agents; Liver Cirrhosis; Methionine; Mice; Mice, Knockout; Neutrophil Infiltration; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proto-Oncogene Proteins c-met | 2014 |
Metabolomics-based search for therapeutic agents for non-alcoholic steatohepatitis.
Topics: Animals; Choline; Diet; Fatty Liver; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Oxidative Stress; Taurine | 2014 |
Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet.
Topics: Animal Feed; Animals; Apoptosis; Biomarkers; Choline Deficiency; Disease Progression; Drug Administration Schedule; Endoplasmic Reticulum Stress; Fatty Liver; Gastrointestinal Agents; Immunoblotting; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Taurochenodeoxycholic Acid | 2014 |
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.
Topics: Amitriptyline; Animals; Autophagy; Ceramides; Cholesterol; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Endoplasmic Reticulum Stress; Humans; Liver; Lysosomes; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Permeability; Sphingomyelin Phosphodiesterase; Sphingomyelins | 2014 |
Retinol status and expression of retinol-related proteins in methionine-choline deficient rats.
Topics: Acyltransferases; Aldehyde Dehydrogenase; Animals; beta-Carotene 15,15'-Monooxygenase; Choline Deficiency; Intestinal Mucosa; Kidney; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats, Wistar; Retinol-Binding Proteins, Cellular; Testis; Vitamin A | 2014 |
Protective effects and mechanisms of total alkaloids of Rubus alceaefolius Poir on non‑alcoholic fatty liver disease in rats.
Topics: Adiponectin; Administration, Oral; Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Choline; Diet, High-Fat; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Leptin; Liver; Methionine; Non-alcoholic Fatty Liver Disease; Protective Agents; Rats; Rats, Sprague-Dawley; Resistin; Rubus | 2014 |
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Acids; Fibroblast Growth Factors; Hepatitis; Inflammation Mediators; Infusions, Subcutaneous; Lipid Peroxidation; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Recombinant Proteins; RNA, Messenger; Severity of Illness Index; Time Factors | 2014 |
3, 3'-Diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance.
Topics: Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Choline; Diet; Female; Indoles; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Spleen; T-Lymphocytes, Regulatory; Th17 Cells; Toll-Like Receptor 4 | 2014 |
Deficiency of periostin protects mice against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis.
Topics: Animals; Cell Adhesion Molecules; Choline Deficiency; Diet; Humans; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2015 |
Branched-Chain Amino Acid-Rich Supplements Containing Microelements Have Antioxidant Effects on Nonalcoholic Steatohepatitis in Mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aldehydes; Amino Acids, Branched-Chain; Animals; Antioxidants; Choline; Deoxyguanosine; Diet; Dietary Supplements; Endoplasmic Reticulum; Liver; Male; Methionine; Mice; Micronutrients; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Receptor, Insulin; Vitamins | 2016 |
Hepatoprotective and antioxidant activities of extracts from Salvia-Nelumbinis naturalis against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet in mice.
Topics: Animal Feed; Animals; Antioxidants; Base Sequence; Choline; DNA Primers; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Plant Extracts; Polymerase Chain Reaction; Salvia | 2014 |
Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis.
Topics: Animals; Cholesterol; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Acids; Female; Inflammation Mediators; Iron; Lipid Peroxidation; Liver; Male; Methionine; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; RNA-Binding Proteins; Time Factors; Up-Regulation | 2014 |
6-gingerol protects against nutritional steatohepatitis by regulating key genes related to inflammation and lipid metabolism.
Topics: Animals; Catechols; Chemokine CCL2; Choline Deficiency; Disease Models, Animal; Fatty Alcohols; Fatty Liver; Inflammation; Interleukin-6; Lipid Metabolism; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Plant Extracts; Tumor Necrosis Factor-alpha | 2015 |
MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Cluster Analysis; Diet; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Liver Cirrhosis; Male; Metformin; Methionine; Mice; MicroRNAs; Non-alcoholic Fatty Liver Disease; Transcriptome | 2015 |
Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet.
Topics: Adipocytes, White; Animals; CD36 Antigens; Cells, Cultured; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fibroblast Growth Factors; Hepatocytes; Lipase; Lipolysis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphatidate Phosphatase; PPAR alpha; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Triglycerides | 2015 |
Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.
Topics: Alcohol Dehydrogenase; Animals; Choline Deficiency; Diet; Disease Progression; Fatty Liver; Glutathione; Lipid Metabolism; Liver; Methionine; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease | 2015 |
Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis.
Topics: Animals; Biomarkers; Blotting, Western; Choline Deficiency; Diet; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Immunoenzyme Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
MRI versus histological methods for time course monitoring of steatosis amount in a murine model of NAFLD.
Topics: Adipose Tissue; Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Humans; Image Interpretation, Computer-Assisted; Liver; Magnetic Resonance Imaging; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; Statistics as Topic; Triglycerides | 2015 |
[Emodin worsens methionine-choline-deficient diet-induced non-alcoholic fatty liver disease in mice].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Choline; Diet; Emodin; Liver; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Organ Size; Spleen | 2015 |
Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Catechin; Choline Deficiency; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Inflammation Mediators; Lipids; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Signal Transduction; Transforming Growth Factor beta | 2015 |
The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.
Topics: Animals; Apoptosis; Choline Deficiency; Cytoprotection; Diet, High-Fat; Enzyme Inhibitors; Febuxostat; Gout Suppressants; Hyperuricemia; Liver; Liver Cirrhosis, Experimental; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Thiazoles; Uric Acid; Xanthine Oxidase | 2015 |
Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis.
Topics: Animals; Choline; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Kidney; Liver; Metformin; Methionine; Mice; Mice, Inbred C57BL; Mice, Obese; Non-alcoholic Fatty Liver Disease; Octamer Transcription Factor-1; Organic Cation Transport Proteins; Organic Cation Transporter 2; RNA, Messenger; Tissue Distribution | 2015 |
Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.
Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Triglycerides | 2015 |
Noninvasive estimation of disease activity and liver fibrosis in nonalcoholic fatty liver disease using anthropometric and biochemical characteristics, including insulin, insulin resistance, and 13C-methionine breath test.
Topics: Anthropometry; Biomarkers; Breath Tests; Carbon Isotopes; Female; gamma-Glutamyltransferase; Humans; Insulin; Insulin Resistance; Liver Cirrhosis; Male; Methionine; Middle Aged; Non-alcoholic Fatty Liver Disease; ROC Curve | 2015 |
Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Diet; Dietary Carbohydrates; Disease Models, Animal; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Inbred C3H; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitates; Sucrose | 2015 |
Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease.
Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Triglycerides | 2015 |
Protective effect of ursodeoxycholic acid, resveratrol, and N-acetylcysteine on nonalcoholic fatty liver disease in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Choline Deficiency; Cytoprotection; Disease Models, Animal; Hypolipidemic Agents; Lipids; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats, Wistar; Resveratrol; Stilbenes; Ursodeoxycholic Acid | 2016 |
Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance.
Topics: Administration, Oral; Animals; Biomarkers; Blood Glucose; Chemical and Drug Induced Liver Injury; Choline Deficiency; Concanavalin A; Cytoprotection; Diet, High-Fat; Disease Models, Animal; Glycine max; Immunologic Factors; Insulin; Insulin Resistance; Lipids; Liver; Metabolic Syndrome; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Plant Extracts; T-Lymphocytes, Regulatory; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.
Topics: Animals; Carrier Proteins; Choline Deficiency; Intracellular Signaling Peptides and Proteins; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Palmitates; Ubiquitin; Ubiquitin-Protein Ligases | 2015 |
Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.
Topics: Animals; Case-Control Studies; Cell Death; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Hepatocytes; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Palmitic Acid; Rats; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2015 |
CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis.
Topics: Actins; Animals; Antigens, Differentiation; Antigens, Ly; CD11b Antigen; Choline Deficiency; CX3C Chemokine Receptor 1; Dendritic Cells; Diet; Disease Progression; Flow Cytometry; Gene Expression; Immunohistochemistry; Inflammation; Liver; Methionine; Mice, Inbred C57BL; Monocytes; Non-alcoholic Fatty Liver Disease; Receptors, Chemokine; Reverse Transcriptase Polymerase Chain Reaction; Sulfides; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2015 |
Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Acyl Coenzyme A; Adenosylhomocysteinase; Animals; B-Lymphocytes; Betaine-Homocysteine S-Methyltransferase; Blood Chemical Analysis; Cystathionine beta-Synthase; Cysteine; Diet, High-Fat; Dipeptides; DNA Methylation; Female; Glutathione; Glycine N-Methyltransferase; Homocysteine; Liver; Metabolic Networks and Pathways; Metabolome; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Random Allocation | 2015 |
CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy.
Topics: Animals; Autophagy; Choline Deficiency; Cytokines; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Humans; Lipogenesis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Receptors, CXCR3; Th1 Cells; Th17 Cells | 2016 |
Evaluation of Nonalcoholic Fatty Liver Disease in C57BL/6J Mice by Using MRI and Histopathologic Analyses.
Topics: Animals; Area Under Curve; Biopsy; Choline Deficiency; Disease Models, Animal; Liver; Magnetic Resonance Imaging; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; Reproducibility of Results; ROC Curve; Severity of Illness Index | 2015 |
Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Choline Deficiency; Cytokines; Drug Evaluation, Preclinical; Gene Expression; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Resveratrol; Stilbenes | 2015 |
The Ethanol Extract from Lonicera japonica Thunb. Regresses Nonalcoholic Steatohepatitis in a Methionine- and Choline-Deficient Diet-Fed Animal Model.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Liver; Liver Cirrhosis; Lonicera; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phytotherapy; Plant Extracts; Signal Transduction | 2015 |
Protective role of autophagy in methionine-choline deficient diet-induced advanced nonalcoholic steatohepatitis in mice.
Topics: Animals; Autophagy; Choline; Diet; Endoplasmic Reticulum Stress; Fibrosis; Liver; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Non-alcoholic Fatty Liver Disease | 2016 |
Treatment with geraniol ameliorates methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in rats.
Topics: Acyclic Monoterpenes; Adenosine Triphosphate; Animals; Carnitine O-Palmitoyltransferase; Choline Deficiency; DNA, Mitochondrial; Electron Transport Chain Complex Proteins; Gene Expression; Male; Methionine; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidative Stress; PPAR alpha; Prohibitins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Repressor Proteins; Terpenes | 2016 |
Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.
Topics: Animals; Biomarkers; Choline Deficiency; Colon; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Gene Expression Regulation; Hormones, Ectopic; Intercellular Signaling Peptides and Proteins; Kupffer Cells; Liver; Macrophages; Male; Methionine; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Toll-Like Receptor 4; Transcription, Genetic | 2016 |
Relationship between liver tissue stiffness and histopathological findings analyzed by shear wave elastography and compression testing in rats with non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Elastic Modulus; Elasticity Imaging Techniques; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats, Wistar; Severity of Illness Index | 2016 |
Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cholesterol; Choline; Choline Deficiency; Curcuma; Curcumin; Diarylheptanoids; Drug Synergism; Food, Formulated; Lipogenesis; Liver; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Organ Size; Protective Agents; Silymarin; Triglycerides | 2016 |
Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis.
Topics: Animals; Choline; Diet; Disease Models, Animal; Hepatitis; Interleukin-17; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Receptors, Interleukin-17; Signal Transduction; T-Lymphocytes | 2016 |
Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells.
Topics: Actins; Animals; Blotting, Western; Cells, Cultured; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fluorescent Antibody Technique; Hepatic Stellate Cells; Immunoenzyme Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sirtuin 3; Succinate Dehydrogenase | 2016 |
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Case-Control Studies; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Choline; Diet; Disease Models, Animal; Genes, myc; Hepatocytes; Humans; Linoleic Acid; Lipid Metabolism; Liver; Liver Neoplasms; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Reactive Oxygen Species | 2016 |
Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis.
Topics: Animals; Caspase 1; CCAAT-Enhancer-Binding Proteins; Choline Deficiency; Cytokines; Lipoproteins, LDL; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Perilipin-2; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Triglycerides | 2016 |
Methionine-choline deprivation alters liver and brain acetylcholinesterase activity in C57BL6 mice.
Topics: Acetylcholinesterase; Animals; Brain; Choline Deficiency; Enzyme Activation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Tissue Distribution | 2016 |
Mainstream cigarette smoke accelerates the progression of nonalcoholic steatohepatitis by modulating Kupffer cell-mediated hepatocellular apoptosis in adolescent mice.
Topics: Age Factors; Animals; Apoptosis; Cells, Cultured; Choline Deficiency; Cytokines; Disease Models, Animal; Disease Progression; Hepatocytes; Inflammation Mediators; Kupffer Cells; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Paracrine Communication; Severity of Illness Index; Signal Transduction; Smoke; Smoking; Time Factors | 2016 |
Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system.
Topics: Animals; Cholesterol; Choline Deficiency; CRISPR-Cas Systems; Cyclic AMP Response Element-Binding Protein; Female; Hepatitis, Animal; Hyperlipidemias; Insulin; Intestine, Small; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Sterol Regulatory Element Binding Protein 2; Triglycerides; Up-Regulation | 2016 |
S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway.
Topics: Animals; Antioxidants; Biomarkers; Choline Deficiency; Cysteine; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Hep G2 Cells; Humans; Lipid Peroxidation; Liver; Male; Membrane Proteins; Methionine; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Transfection | 2016 |
Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet.
Topics: Animals; Bupropion; Choline; Choline Deficiency; Cytochrome P-450 CYP2B1; Diet, High-Fat; Disease Models, Animal; Humans; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2016 |
Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice.
Topics: Animals; Apoptosis; Cells, Cultured; Choline Deficiency; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Gene Expression; Hepatic Stellate Cells; Hepatocytes; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Recombinant Proteins | 2016 |
Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.
Topics: Adenine; Animals; Choline; Diet; Glomerular Filtration Rate; Kidney; Male; Methionine; Non-alcoholic Fatty Liver Disease; Organophosphonates; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors | 2016 |
Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cells, Cultured; Choline Deficiency; Diet; Disease Models, Animal; Female; Fibroblast Growth Factors; Humans; Lipolysis; Liver; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Ovary; Sex Factors; Testis; Uncoupling Protein 1; Up-Regulation | 2016 |
Fenofibrate nanoliposome: Preparation and its inhibitory effects on nonalcoholic fatty liver disease in mice.
Topics: Animals; Choline; Fenofibrate; Hypolipidemic Agents; Liposomes; Liver; Methionine; Mice; Nanoparticles; Non-alcoholic Fatty Liver Disease | 2016 |
Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Diet; Fatty Acids; Glycyrrhiza; Glycyrrhizic Acid; Inflammation; Lipid Metabolism; Lipogenesis; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Triglycerides | 2016 |
Nonalcoholic Steatohepatitis Modulates Membrane Protein Retrieval and Insertion Processes.
Topics: Animals; Cell Membrane; Choline; Cytoskeletal Proteins; Intracellular Signaling Peptides and Proteins; Liver; Male; Membrane Proteins; Methionine; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphorylation; Protein Kinases; Protein Transport; Rats; Rats, Sprague-Dawley | 2016 |
Modeling fatty liver disease in animals: Is there an optimal approach, and is the effort worthwhile?
Topics: Animals; Choline Deficiency; Disease Models, Animal; Humans; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2016 |
Evaluation of Methionine Content in a High-Fat and Choline-Deficient Diet on Body Weight Gain and the Development of Non-Alcoholic Steatohepatitis in Mice.
Topics: Animals; Biomarkers; Choline; Diet, High-Fat; Fibrosis; Gene Expression; Glucose Tolerance Test; Lipids; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Time Factors; Weight Gain | 2016 |
New Potential Biomarker Proteins for Alcoholic Liver Disease Identified by a Comparative Proteomics Approach.
Topics: Animals; Biomarkers; Choline Deficiency; Disease Models, Animal; Gene Expression Regulation; Liver Diseases, Alcoholic; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proteomics | 2017 |
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Topics: Animals; Chenodeoxycholic Acid; Cholestenones; Choline Deficiency; Dose-Response Relationship, Drug; Fibrosis; Gene Expression; Hepatocytes; Lipid Metabolism; Lipogenesis; Liver; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Pregnenediones; Primary Cell Culture; Protective Agents; Receptors, Cytoplasmic and Nuclear | 2017 |
Altered Gut Microbiota Composition and Immune Response in Experimental Steatohepatitis Mouse Models.
Topics: Alanine Transaminase; Animals; Bacteroidetes; Cholesterol; Choline; Clostridiales; Diet; Diet, High-Fat; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Gastrointestinal Microbiome; Ileum; Interleukin-17; Intestines; Liver; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Portal Vein; Real-Time Polymerase Chain Reaction; Severity of Illness Index; Triglycerides | 2017 |
Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency.
Topics: Animals; Asteraceae; Caffeic Acids; Cell Line; Choline Deficiency; Disease Models, Animal; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Lipid Metabolism; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Plant Extracts; Succinates | 2017 |
Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Chemokine CCL2; Chimera; Choline; Choline Deficiency; Down-Regulation; Interleukin-12 Subunit p35; Kupffer Cells; Lipopolysaccharides; Liver; Male; Methionine; Mice; Mice, Knockout; NF-kappa B; Non-alcoholic Fatty Liver Disease; Palmitic Acid; Phosphorylation; PPAR alpha; Tumor Necrosis Factor-alpha; Up-Regulation; Vagotomy; Vagus Nerve; Vagus Nerve Stimulation | 2017 |
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
Topics: Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Choline; Diet, High-Fat; Disease Models, Animal; Hep G2 Cells; Hepatic Stellate Cells; Humans; Liver Neoplasms; Male; Methionine; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; RAW 264.7 Cells; Tubulin; Up-Regulation | 2017 |
An estrogen receptor β-selective agonist inhibits non-alcoholic steatohepatitis in preclinical models by regulating bile acid and xenobiotic receptors.
Topics: Animals; Bile Acids and Salts; Choline Deficiency; Diet; Estrogen Receptor beta; Isoquinolines; Liver; Male; Metabolomics; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2017 |
Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis.
Topics: Animals; Cholesterol; DEAD-box RNA Helicases; Diet; Gene Knockout Techniques; Hydroxymethylglutaryl CoA Reductases; Male; Methionine; Mice; MicroRNAs; Non-alcoholic Fatty Liver Disease; Ribonuclease III; RNA, Messenger | 2017 |
Modulatory role of Co-enzyme Q10 on methionine and choline deficient diet-induced non-alcoholic steatohepatitis (NASH) in albino rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Brain-Derived Neurotrophic Factor; Choline; Choline Deficiency; Diet; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Interleukin-6; Liver; Male; Methionine; Neuroprotective Agents; Nitric Oxide; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Serum Albumin; Ubiquinone | 2017 |
β
Topics: Animals; Cell Adhesion Molecules; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Disease Progression; Integrin beta Chains; Liver; Lymphocyte Subsets; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucoproteins; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2017 |
Influence of hyperglycemia on liver inflammatory conditions in the early phase of non-alcoholic fatty liver disease in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Hyperglycemia; Inflammation; Liver; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2017 |
p16 deficiency promotes nonalcoholic steatohepatitis via regulation of hepatic oxidative stress.
Topics: Animals; Cell Line, Tumor; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; Disease Models, Animal; Food, Formulated; Gene Expression Regulation; Hepatocytes; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred BALB C; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidative Stress; RNA, Small Interfering | 2017 |
Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet.
Topics: Actins; Animals; Choline Deficiency; Connective Tissue Growth Factor; Disease Progression; Eicosapentaenoic Acid; Fatty Liver; Liver; Liver Cirrhosis; Male; Methionine; Non-alcoholic Fatty Liver Disease; Procollagen; Rats; Rats, Wistar; Reactive Oxygen Species; Transforming Growth Factor beta1; Treatment Outcome; Triglycerides | 2011 |
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.
Topics: Animals; Cell Line; Choline Deficiency; Diet; Fatty Liver; Hedgehog Proteins; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Osteopontin; Up-Regulation; Veratrum Alkaloids | 2011 |
Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Cell Proliferation; Choline Deficiency; Constitutive Androstane Receptor; Disease Models, Animal; Fatty Liver; Genes, myc; Hep G2 Cells; Humans; Ki-67 Antigen; Liver Neoplasms, Experimental; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Pyridines; Receptors, Cytoplasmic and Nuclear | 2011 |
Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice.
Topics: Actins; Alanine Transaminase; Animals; Choline Deficiency; Collagen; Fatty Liver; Female; Genotype; Lipid Peroxidation; Liver; Liver Cirrhosis, Experimental; Lymphocyte Antigen 96; Matrix Metalloproteinase 2; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phenotype; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Tissue Inhibitor of Metalloproteinase-1; Toll-Like Receptor 4; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha | 2011 |
Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine.
Topics: Adipokines; Adult; Aged; Calorimetry, Indirect; Case-Control Studies; Cysteine; Fatty Liver; Female; Glutathione; Homocysteine; Humans; Inflammation Mediators; Insulin Resistance; Liver; Male; Methionine; Methylation; Middle Aged; Non-alcoholic Fatty Liver Disease; Phenylalanine; Proteins; Urea; Young Adult | 2011 |
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.
Topics: Animals; Apoptosis; Caspase 1; Choline Deficiency; Dietary Fats; Disease Models, Animal; Endotoxins; Fatty Acids; Fatty Liver; Female; Hepatocytes; Immune System; Inflammasomes; Interleukin-1beta; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2011 |
The effect of hepatic ischemia reperfusion injury in a murine model of nonalcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Diet; Disease Models, Animal; Disease Progression; Fatty Liver; Ischemia; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Peroxidase; Reperfusion Injury | 2011 |
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis.
Topics: Activating Transcription Factor 6; Animal Feed; Animals; Choline; Choline Deficiency; Cytokines; Diabetes Mellitus, Experimental; Eukaryotic Initiation Factor-2; Fatty Liver; Female; JNK Mitogen-Activated Protein Kinases; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Non-alcoholic Fatty Liver Disease; Obesity; Protein Phosphatase 1; Signal Transduction; Transcription Factor CHOP; Unfolded Protein Response | 2011 |
The non-invasive (13)C-methionine breath test detects hepatic mitochondrial dysfunction as a marker of disease activity in non-alcoholic steatohepatitis.
Topics: Adult; Aged; Biomarkers; Breath Tests; Carbon Isotopes; Case-Control Studies; Cross-Sectional Studies; Fatty Liver; Female; Humans; Male; Methionine; Middle Aged; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; ROC Curve | 2011 |
Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet.
Topics: Alanine Transaminase; Animals; Bezafibrate; Calcium Channel Blockers; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Hypolipidemic Agents; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Nifedipine; Non-alcoholic Fatty Liver Disease; PPAR gamma; Rats; Rats, Wistar | 2012 |
Decreased accumulation of ultrasound contrast in the liver of nonalcoholic steatohepatitis rat model.
Topics: Animals; Body Weight; Choline Deficiency; Contrast Media; Diet; Disease Models, Animal; Fatty Liver; Kupffer Cells; Leptin; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Ultrasonography | 2011 |
Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease.
Topics: Animals; Choline Deficiency; Diacylglycerol O-Acyltransferase; DNA-Binding Proteins; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Fatty Acid Synthases; Fatty Acid Transport Proteins; Fatty Acids; Fatty Liver; Fibrosis; Gene Expression; Glycerol-3-Phosphate O-Acyltransferase; Lipid Mobilization; Lipogenesis; Liver; Membrane Proteins; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphorylation; Regulatory Factor X Transcription Factors; Sterol Regulatory Element Binding Protein 1; Transcription Factor CHOP; Transcription Factors | 2011 |
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Deficiency; Disease Models, Animal; DNA, Mitochondrial; Fatty Acids, Nonesterified; Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Humans; Liver; Lysosomes; Membrane Potential, Mitochondrial; Methionine; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Stress; PPAR gamma; Rats; Rats, Inbred OLETF; Rats, Long-Evans; RNA, Messenger; Thioctic Acid; Time Factors | 2011 |
A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; DNA-Binding Proteins; Fatty Liver; Feasibility Studies; Gene Expression Regulation; Liver Transplantation; Male; Methionine; Mice; Mice, SCID; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; Phenotype; Tumor Necrosis Factor-alpha | 2012 |
Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis.
Topics: Animals; Anticholesteremic Agents; Azetidines; Bile Acids and Salts; Biliary Tract; Biological Transport; Choline Deficiency; Diet; Ezetimibe; Fatty Liver; Glucuronosyltransferase; Intestinal Mucosa; Liver; Male; Membrane Transport Proteins; Methionine; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2012 |
Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver.
Topics: Adiponectin; Aged; Animals; Bile Ducts; Choline; Diet; Fatty Liver; Female; Hepatic Stellate Cells; Hepatocytes; Humans; Kupffer Cells; Liver; Male; Methionine; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Receptors, Chemokine; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Up-Regulation | 2012 |
Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline Deficiency; Cytokines; Diet; Fatty Liver; Gene Expression; Glutathione; Insulin Resistance; Isoprostanes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Methionine; Mice; Myocardium; Nitrates; Nitrites; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphorylation; Silybin; Silymarin; Statistics, Nonparametric | 2012 |
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.
Topics: Analysis of Variance; Animals; Bile Acids and Salts; Biopsy, Needle; Cells, Cultured; Diet; Disease Models, Animal; Fatty Liver; Hepatocytes; Homeostasis; Immunohistochemistry; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phospholipids; Polymerase Chain Reaction; Random Allocation | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; Colon; Cytoskeletal Proteins; Disease Models, Animal; Disease Progression; Fatty Liver; Inflammasomes; Inflammation; Interleukin-18; Male; Metagenome; Methionine; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Obesity; Receptors, Cell Surface; RNA, Ribosomal, 16S; Toll-Like Receptor 4; Toll-Like Receptor 9; Tumor Necrosis Factor-alpha | 2012 |
Pentoxifylline attenuates methionine- and choline-deficient-diet-induced steatohepatitis by suppressing TNF-α expression and endoplasmic reticulum stress.
Topics: Alanine Transaminase; Animals; Cell Line; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fatty Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Unfolded Protein Response | 2012 |
Identification of liver proteins altered by type 2 diabetes mellitus in obese subjects.
Topics: Adult; Aldehydes; Biomarkers; Biopsy; Diabetes Mellitus, Type 2; Electrophoresis, Gel, Two-Dimensional; Fatty Liver; Female; Glutathione; Humans; Liver; Methionine; Middle Aged; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Obesity, Morbid; Oxidative Stress; Protein Carbonylation; Proteins; Proteomics; Severity of Illness Index; Spain; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2012 |
[Mechanism of hepatocyte apoptosis in rats with liver fibrosis induced by lipogenic methionine-choline-deficient diet].
Topics: Animals; Apoptosis; Caspase 12; Caspase 3; Caspase 7; Caspase 9; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fatty Liver; Heat-Shock Proteins; Hepatocytes; Liver Cirrhosis; Male; Methionine; Mitogen-Activated Protein Kinases; Non-alcoholic Fatty Liver Disease; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction | 2012 |
Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Choline Deficiency; Disease Models, Animal; Fatty Liver; Homeostasis; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Obese; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Silybin; Silymarin; Translational Research, Biomedical | 2012 |
p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.
Topics: Animals; Apoptosis; Caspase 3; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Disease Progression; Fatty Liver; Hepatocytes; Humans; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Up-Regulation | 2012 |
Altered arsenic disposition in experimental nonalcoholic fatty liver disease.
Topics: Animals; Arsenates; Arsenic Trioxide; Arsenicals; Biotransformation; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Environmental Pollutants; Fatty Liver; Kidney; Liver; Male; Methionine; Methyltransferases; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Oxides | 2012 |
Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.
Topics: Analysis of Variance; Animals; Arachidonic Acid; Benzofurans; Choline; Clodronic Acid; Diet, High-Fat; DNA Primers; Fatty Acids, Unsaturated; Fatty Liver; Gadolinium; Hemodynamics; Hypertension, Portal; Insulin Resistance; Kupffer Cells; Leptin; Methionine; Methoxamine; Microcirculation; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Receptors, Thromboxane A2, Prostaglandin H2; RNA, Messenger; Sulfonylurea Compounds; Thiobarbituric Acid Reactive Substances; Thromboxane A2 | 2012 |
Glycine alleviates liver injury induced by deficiency in methionine and or choline in rats.
Topics: Animals; Antioxidants; Choline Deficiency; Fatty Liver; Glycine; Lipid Metabolism; Lipid Peroxidation; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2012 |
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Collagen Type I; Collagen Type III; Cyclooxygenase 2; Diet; Disease Models, Animal; Fatty Liver; Fibrosis; HMGB1 Protein; Inflammation; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Quercetin; RNA, Messenger; Smad Proteins; Thiobarbituric Acid Reactive Substances; Toll-Like Receptor 4; Up-Regulation | 2012 |
The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Intracellular Signaling Peptides and Proteins; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha | 2013 |
Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production.
Topics: Animals; Chemokine CCL2; Chemokine CXCL10; Choline; Diet; Disease Models, Animal; Fatty Liver; Female; Humans; Kupffer Cells; Methionine; Mice; Mice, Inbred C57BL; Monocytes; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2012 |
Dandelion leaf extract protects against liver injury induced by methionine- and choline-deficient diet in mice.
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Humans; Interleukin-6; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Plant Extracts; Plant Leaves; Protective Agents; Taraxacum; Tumor Necrosis Factor-alpha | 2013 |
Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Choline Deficiency; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Hepatocytes; In Vitro Techniques; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Neovascularization, Pathologic; Non-alcoholic Fatty Liver Disease; Placenta Growth Factor; Pregnancy Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Diet, Fat-Restricted; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred A; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Specific Pathogen-Free Organisms; Time Factors | 2013 |
Changes in the hepatic mitochondrial and membrane proteome in mice fed a non-alcoholic steatohepatitis inducing diet.
Topics: Animals; Cations; Cell Membrane; Cholesterol; Diet; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Female; Fibrosis; Gene Expression Profiling; Glutathione Transferase; Glycerol; Inflammation; Lipids; Liver; Mass Spectrometry; Methionine; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Polyamines; Proteome; Proteomics; Urea | 2013 |