methionine has been researched along with Disease Models, Animal in 523 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (4.21) | 18.7374 |
| 1990's | 23 (4.40) | 18.2507 |
| 2000's | 121 (23.14) | 29.6817 |
| 2010's | 270 (51.63) | 24.3611 |
| 2020's | 87 (16.63) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, D; Piao, H; Wang, W | 1 |
| Guo, X; Han, J; Kawai, D; Koyama, T; Motoo, Y; Satoh, T; Yamada, S; Yamaguchi, R; Zhang, J; Zhou, X | 1 |
| Ding, J; Dou, GR; Duan, JL; Fang, ZQ; Liu, JJ; Ruan, B; Song, P; Wang, L; Xu, C; Xu, H; Yue, ZS | 1 |
| Bian, D; Gan, J; Liu, R; Wang, C; Wen, F; Wu, X | 1 |
| Alastrué-Vera, V; Arnal, C; Barranquero, C; García-Gil, A; Gascón, S; Gonzalo-Romeo, G; Güemes, A; Gutiérrez-Blázquez, D; Herrera-Marcos, LV; Herrero-Continente, T; Lou-Bonafonte, JM; Macías-Herranz, M; Martínez-Beamonte, R; Osada, J; Puente-Lanzarote, JJ; Rodríguez-Yoldi, MJ; Surra, JC | 1 |
| Akahoshi, N; Ishii, I; Ito, S; Kamata, S; Kamichatani, W; Koizumi, M; Miura, A; Nagata, T; Ohtani, H; Shimonaga, A; Tosaka, Y; Tsushima, M | 1 |
| Ahmeda, AF; Al Zarzour, RH; Alsalahi, A; Alshawsh, MA; Alshehade, SA; Mahmoud, AM; Saghir, SAM | 1 |
| Abd-Elhafiz, HI; Faried, MA; Khodir, SA; Sweed, EM | 1 |
| Kawai, K; Kobayashi, M; Matsue, M; Mizutani, A; Muranaka, Y; Nakamoto, K; Nishi, K; Nishii, R; Okamoto, S; Shikano, N; Yamazaki, K | 1 |
| Chen, H; Li, C; Liu, X; Wang, P; Wu, C; Yang, X; Yang, Y; Yao, S; Yin, R; Yu, M; Zhou, B | 1 |
| Navik, U; Sharma, N; Sheth, VG; Tikoo, K | 1 |
| Albano, E; Gadipudi, LL; Perretti, M; Provera, A; Ramavath, NN; Reutelingsperger, C; Sutti, S | 1 |
| Gajbhiye, S; Jalgaonkar, S; Khatri, N; Parmar, U; Sayyed, M; Shankar, A; Tripathi, R | 1 |
| Aoki, Y; Han, Q; Hoffman, RM; Hozumi, C; Kubota, Y; Masaki, N; Tsunoda, T; Yamamoto, J | 1 |
| Cai, L; Jiang, F; Li, Z; Lian, B; Lin, F; Zhang, XK; Zhang, Z | 1 |
| Alpini, G; Francis, H; Glaser, S; Guo, X; Li, H; Li, Q; Lu, B; Wang, F; Wu, C; Xie, L; Zhu, B | 1 |
| Jeong, W; Kang, YH; Kim, N; Kwon, M; Lee, GR; Lee, HI; Lee, J; Song, HJ; Yeo, CY | 1 |
| Cui, C; Han, Y; Li, G; Li, H; Yu, H; Zhang, B | 1 |
| Guo, J; Kang, Y; Li, C; Luo, Y; Song, Y; Sun, D; Ye, L; Yin, F; Yu, J; Zhang, X | 1 |
| Aoki, Y; Bouvet, M; Han, Q; Hoffman, RM; Hozumi, C; Kubota, Y; Masaki, N; Obara, K; Samonte, C; Wu, J; Wu, NF | 1 |
| Ding, C; Ding, R; Dong, Z; Han, W; Jin, S; Li, D; Li, H; Ma, M; Song, M; Xu, L; Zhang, F; Zhang, O; Zhao, Y | 1 |
| Gao, W; Guo, L; Huang, L; Liang, Y; Ma, L; Man, S; Yan, M | 1 |
| Dong, C; Li, L; Liu, F; Xue, R; Yang, L; Yue, W; Zhang, H | 1 |
| Buechler, C; Girke, P; Haberl, EM; Krautbauer, S; Liebisch, G; Mages, W; Pohl, R; Rein-Fischboeck, L | 1 |
| Ding, T; Guan, Z; Jia, S; Wang, R; Zhang, D; Zhang, J; Zhao, X | 1 |
| Alarcon, PC; Damen, MSMA; Divanovic, S; Giles, DA; Moreno-Fernandez, ME; Oates, JR; Sawada, K; Stankiewicz, TE; Szabo, S | 1 |
| Bahn, YS; Choi, Y; Jang, YB; Lee, HS; Lee, JS; Lee, SH; Lee, Y; Shin, BN | 1 |
| Gong, X; Hu, J; Jiang, N; Kuang, G; Liu, H; Liu, J; Wan, J; Wu, S; Yin, X | 1 |
| Ikeda, Y; Matsuda, S | 1 |
| Barbieri, A; Campagnoli, LIM; Croce, AC; Di Pasqua, LG; Ferrigno, A; Marchesi, N; Pascale, A; Vairetti, M | 1 |
| Albuquerque, M; Boulanger, CM; Calmels, M; Casteleyn, C; Gilgenkrantz, H; Hammoutene, A; Paradis, V; Pravisani, R; Rautou, PE; Sadoine, J; Slimani, L; Tanguy, M | 1 |
| Chen, Z; Chu, W; Li, P; Liu, Y; Mi, Y; Niu, B; Wu, X; Zhou, H; Zhou, Y | 1 |
| Abe, A; Miyajima, K; Nakae, D; Nakane, S; Suzuki-Kemuriyama, N; Yuki, M | 1 |
| Do, IG; Kim, J; Kim, SH; Lee, Y; Park, CY; Song, Y; Yang, H | 1 |
| Chen, J; Fang, Y; Huang, L; Liang, G; Lin, J; Liu, X; Luo, W; Qian, C; Wang, Y; Xie, L; Zuo, W | 1 |
| Gee, HY; Kim, DY; Park, JY | 1 |
| Branchford, BR; Bublil, EM; Cox, A; di Paola, J; Kraus, JP; Majtan, T; Park, I | 1 |
| Amiel, A; Aurich, MK; Canlet, C; Dardevet, D; Debrauwer, L; Jourdan, F; Polakof, S; Poupin, N; Rémond, D; Savary-Auzeloux, I; Thiele, I; Tremblay-Franco, M | 1 |
| Arista Romeu, EJ; Campos-Espinosa, A; de la Rosa Vázquez, JM; Escobedo, G; Fabila Bustos, DA; Guzmán, C; Moreno-González, J; Romero-Bello, II; Stolik, S; Valor, A | 1 |
| Buechler, C; Feder, S; Haberl, EM; Krautbauer, S; Liebisch, G; Pohl, R; Rein-Fischboeck, L | 1 |
| Codella, R; Luzi, L; Mollica, G; Montesano, A; Senesi, P; Terruzzi, I; Vacante, F | 1 |
| Hiroe, M; Imanaka-Yoshida, K; Inaki, A; Kinuya, S; Matsunari, I; Ogawa, K; Shiba, K; Taki, J; Wakabayashi, H | 1 |
| Chen, X; Huang, YM; Li, CP; Lü, MH; Shi, L; Wang, XM; Wang, XY | 1 |
| Anselmo, A; Bernstein, BE; Brumbaugh, J; Charlton, J; Choi, J; Coffey, A; Di Stefano, B; Hochedlinger, K; Hock, H; Huebner, AJ; Ji, F; Kim, IS; Meissner, A; Sadreyev, RI; Schindler, JW; Schwarz, BA; Walsh, RM | 1 |
| Ge, K; Jia, C; Lu, J; Zhu, H | 1 |
| Barchukov, VV; Kryzhanovskii, SA; Seredenin, SB; Tsorin, IB; Vititnova, MB | 1 |
| Kim, SJ; Kwon, OS; Lee, DE; Lee, HS; Lee, SJ | 1 |
| Elmér, E; Gallay, P; Gregory, M; Grönberg, A; Hansson, MJ; Kuo, J; Longato, L; Massoumi, R; Mazza, G; Moss, S; Pinzani, M; Rombouts, K; Simón Serrano, S | 1 |
| Angulo, S; Carril, E; Godzien, J; Lanzón, B; Rupérez, FJ; Valdecantos, MP; Valverde, ÁM | 1 |
| de Vito, C; Dibner, C; Jornayvaz, FR; Loizides-Mangold, U; Montandon, SA; Somm, E | 1 |
| Czlonkowska, A; Kim, K; Litwin, T; Mazi, TA; Medici, V; Sarode, GV; Shibata, NM | 1 |
| Adamkov, M; Hnilicova, P; Kalenska, D; Kovalska, M; Lehotsky, J; Tothova, B | 1 |
| Fu, R; He, Q; Jiang, R; Liu, Y; Lu, Y; Sun, B; Sun, Q; Tian, W; Wang, J; Xu, X; Yu, H; Zhang, Z | 1 |
| Aburashed, ZO; Alzoubi, KH; Mayyas, F | 1 |
| Jiang, M; Li, HK; Li, LY; ShangGuan, T; Sun, WW; Yang, P; Zhang, ZH; Zhu, P | 1 |
| Brown, RE; Hale, AT; Hudson, BH; Luka, Z; Matta, P; Williams, CS; York, JD | 1 |
| Artyomov, MN; Bourgeois-Daigneault, MC; Chen, J; Chubukov, V; Daigneault, A; Esaulova, E; Foulkes, W; Hayes, S; Johnson, RM; Jones, RG; Koning, R; Krawczyk, CM; Larochelle, C; Ma, EH; Mamane, V; Muhire, BM; Pospisilik, JA; Roddy, TP; Roy, DG; Samborska, B; Sheldon, RD; Shorstova, T; Steadman, M; Swain, A; Williams, KS; Witcher, M | 1 |
| Alonso, C; Aspichueta, P; Barbier-Torres, L; Bizkarguenaga, M; Buqué, X; Cabrera, D; Castro, A; Crespo, J; Delgado, TC; Falcón-Pérez, JM; Fernández-Ramos, D; Fernández-Tussy, P; Goikoetxea-Usandizaga, N; Gómez-Santos, B; Gutiérrez-de Juan, V; Iruzubieta, P; Lopitz-Otsoa, F; Lu, SC; Martínez-Chantar, ML; Mato, JM; Nogueiras, R; Nuñez-García, M; Rodriguez-Agudo, R; Romero-Gomez, M; Serrano-Macia, M; Simon, J; van Liempd, S; Varela-Rey, M; Villa, E; Zubiete-Franco, I | 1 |
| Deng, D; Hirano, E; Igarashi, K; Kaku, T; Lim, HS; Miyai, H; Nakamura, J; Shindo, T; Sugimoto, K; Toledo, A; Tone, T; Yamauchi, A | 1 |
| Kitada, M; Koya, D; Monno, I; Ogura, Y; Xu, J | 1 |
| Cai, K; Jiang, B; Li, X; Sheng, L; Song, Y; Wu, W | 1 |
| Alén, R; Barbas, C; Carrascosa, JM; García-Martínez, I; García-Rodríquez, JJ; Gribble, FM; Guijarro, LG; Lu, VB; Menchén, L; Puerto, M; Reimann, F; Rubio, C; Ruperez, J; Saiz, J; Sanmartín-Salinas, P; Toledo-Lobo, MV; Valverde, ÁM | 1 |
| Arao, Y; Hayatsu, M; Kamimura, K; Kawai, H; Kobayashi, T; Nakano, O; Terai, S; Ushiki, T | 1 |
| Cho, YY; Han, SH; Jang, JH; Jang, JK; Kang, HC; Kim, SW; Lee, HS; Lee, JY; Ma, KH; Yang, G | 1 |
| da Silva, RP; Eudy, BJ; Fernandez, G; Lai, J; Mathews, CE; McDermott, CE | 1 |
| Che, Y; Li, Y; Shi, X; Shi, Y; Si, R; Zhang, Y; Zhong, X | 1 |
| Hojo, N; Kanji, H; Kanzaki, K; Kawakami, T; Kawakami, Y; Kimura, Y; Mori, Y; Otsuki, A; Suzuki-Yamamoto, T; Takahashi, Y; Tanaka, R; Tsukayama, I | 1 |
| Arutjunyan, AV; Kerkeshko, GO; Milyutina, YP; Shcherbitskaia, AD; Tumanova, NL; Vasilev, DS; Zalozniaia, IV | 1 |
| Chen, H; Huang, C; Ke, Z; Li, Y; Tan, S; Zhao, Y; Zhou, Z | 1 |
| Bonnafous, S; Delaunay, F; Gréchez-Cassiau, A; Gual, P; Guérin, S; Leclère, PS; Luci, C; Patouraux, S; Rousseau, D; Ruberto, AA; Subramaniam, M; Teboul, M; Tran, A | 1 |
| Abbott, GW; Alachkar, A; Alhassen, W; Baldi, P; Chen, S; De Silva, A; Yoshimura, R | 1 |
| Bouvet, M; Chawla, SP; Endo, I; Han, Q; Higuchi, T; Hoffman, RM; Homma, Y; Inubushi, S; Matsuyama, R; Miyake, K; Nishino, H; Singh, SR; Sugisawa, N; Tan, Y; Tashiro, Y; Yamamoto, J | 1 |
| Jadžić, J; Jorgačević, B; Labudović-Borović, M; Mladenović, D; Radosavljević, T; Vesković, M; Vučević, D; Vukićević, D | 1 |
| Eto, H; Hyodo, F; Kang, JH; Katayama, Y; Kishimura, A; Li, J; Mori, T; Mu, Y; Zai, K | 1 |
| Balint-Lahat, N; Ben-Ari, Z; Brzezinski, RY; Finchelman, JM; Grossman, E; Hoffer, O; Leor, J; Levin-Kotler, L; Lewis, N; Naftali-Shani, N; Ovadia-Blechman, Z; Rabin, N; Safran, M; Sternfeld, A; Tepper-Shaihov, O; Unis, R; Zimmer, Y | 1 |
| Alonso, C; Azkargorta, M; Bilbao, J; Bizkarguenaga, M; Delacruz-Villar, L; Elortza, F; Fernández-Ramos, D; Goni, FM; Hayardeny, L; Iruarrizaga-Lejarreta, M; Lopitz-Otsoa, F; Lu, SC; Martínez-Chantar, ML; Mato, JM; Mosca, L; Pagano, M; Serrano-Macia, M; Sot, J; Tsvirkun, D; van Liempd, SM | 1 |
| Cardini, B; Fodor, M; Hautz, T; Hermann, M; Maglione, M; Margreiter, C; Mellitzer, V; Oberhuber, R; Öfner, D; Resch, T; Schneeberger, S; Schwelberger, H; Tilg, H; Troppmair, J; Weißenbacher, A; Wieser, V; Zelger, B | 1 |
| Hata, K; Hiwatashi, K; Naya, Y; Ogihara, K; Sasaki, A; Takahashi, J; Toshima, G | 1 |
| Buechler, C; Haberl, EM; Höring, M; Krautbauer, S; Liebisch, G; Pohl, R; Rein-Fischboeck, L | 1 |
| Berardo, C; Di Pasqua, LG; Ferrigno, A; Palladini, G; Perlini, S; Rizzo, V; Vairetti, M | 1 |
| Abe, A; Miyajima, K; Nakae, D; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M | 1 |
| Gu, H; Jia, K; Liu, P; Pan, M; Shen, Z; Sun, C; Yang, K | 1 |
| Ceacero-Heras, D; Córdova, S; de Medina, FS; Gámez-Belmonte, R; Hernández-Chirlaque, C; Martínez-Augustin, O; Tena-Garitaonaindia, M | 1 |
| Arrese, M; Cabrera, D; Hernández, A; Jara, E; Kalergis, AM; Muñoz-Durango, N | 1 |
| Goto, H; Hidoh, Y; Ishii, Y; Nishimura, Y; Sato, M; Takeuchi, K; Yokouchi, C | 1 |
| Jiang, H; Maclean, KN; Mclagan, BM; Phinney, WN; Roede, JR; Stabler, SP | 1 |
| Choi, SE; Han, SJ; Heo, YJ; Jeon, JY; Kang, Y; Kim, DJ; Kim, HJ; Lee, KW; Lee, N | 1 |
| Gong, MJ; Han, B; Huang, P; Zhu, CY; Zou, ZJ | 1 |
| Bassirian, M; Changizi, Z; Komeili-Movahhed, T; Moslehi, A | 1 |
| Breitkopf-Heinlein, K; Ding, H; Gaitantzi, H; Jiang, Q; Li, G; Li, Q; Liu, B; Riedemann, G; Xu, K; Zeng, A | 1 |
| He, J; Huang, C; Huang, H; Jing, X; Li, Y; Liu, Q; Tang, Q; Wu, T; Xia, Y; Xiao, J; Yan, J; Zhang, G; Zhang, J; Zhang, Z; Zhao, Y; Zhou, J | 1 |
| Jiang, Y; Pi, T; Shi, JS; Wei, S | 1 |
| Burkhanova, G; Chernova, K; Enikeev, D; Gerasimova, E; Giniatullin, R; Khaertdinov, N; Sitdikova, G; Zakharov, A | 1 |
| Aizenshtein, E; Hinden, L; Kopan, R; Makayes, Y; Nechama, M; Resnick, E; Shlomi, T; Volovelsky, O | 1 |
| Chen, J; Gu, X; Luo, H; Su, C; Tang, J; Xiao, L; Xiong, F; Zha, L; Zhao, Y; Zheng, Z | 1 |
| Bai, L; Diao, N; Qin, B | 1 |
| Baek, J; Basavarajappa, L; Hoyt, K; Parker, KJ; Poul, SS; Reddy, S; Tai, H | 1 |
| Du, A; Huang, Z; Ji, L; Lu, B; Miao, H; Yan, S; Zhang, S | 1 |
| Cortopassi, G; Hui, CK; Jiang, JX; Montgomery, C; Tomilov, A; Török, NJ | 1 |
| Abe, A; Miyajima, K; Nakae, D; Nakane, S; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M | 1 |
| Abe, M; Akiba, J; Hisamoto, T; Ikezono, Y; Iwamoto, H; Koga, H; Matsui, T; Nakamura, K; Nakamura, T; Torimura, T; Wada, F; Yamagishi, SI; Yoshida, T | 1 |
| Chen, JH; Gu, FJ; Sui, XL; Xu, YP; Ye, L; Zhang, AS | 1 |
| Alfaro, M; Chintapalli, SV; Kang, P; Shankar, K; Thakali, KM; Wankhade, UD; Zhong, Y | 1 |
| Bok, R; Carroll, V; Di Gialleonardo, V; Keshari, KR; Ohliger, MA; Sai, V; Taylor, A; VanCriekinge, M; Von Morze, C; Wang, ZJ; Wilson, DM | 1 |
| Badiali, S; Baselli, GA; Bassani, GA; Dongiovanni, P; Facciotti, F; Fargion, S; Gatti, S; Maggioni, M; Meroni, M; Pietrelli, A; Rametta, R; Trunzo, V; Valenti, L | 1 |
| Li, W; Liu, X; Tu, J; Yang, W | 1 |
| Al-Dhabi, NA; Chen, S; Duraipandiyan, V; Fang, J; Hu, CA; Liu, G; Ni, H; Ren, W; Yin, J; Yin, Y; Yu, L | 1 |
| Chen, Y; Cho, GJ; Chung, HT; Joe, Y; Kim, HJ; Kim, J; Kim, SK; Kim, UH; Park, J; Park, SU; Ryter, SW; Ryu, J; Surh, YJ | 1 |
| Kruger, WD | 1 |
| Asara, JM; Hang, S; Vanhove, AS; Vijayakumar, V; Watnick, PI; Wong, AC | 1 |
| Hara, M; Ichimura, M; Kikuchi, K; Matsumoto, K; Miyakawa, H; Moritoki, Y; Omagari, K; Tsunashima, H; Tsuneyama, K; Yasuda, I | 1 |
| Allen, TL; Febbraio, MA; Henstridge, DC; Kammoun, HL; Kraakman, MJ; Peijs, L; Rose-John, S | 1 |
| Blecha, JE; Flavell, RR; Kwak, T; Mutch, CA; Neumann, KD; Ohliger, MA; Rosenberg, OS; Sriram, R; VanBrocklin, HF; Villanueva-Meyer, JE; Wilson, DM | 1 |
| Abbott, GW; Alachkar, A; Civelli, O; Hamzeh, AR; Lee, SM; Sanathara, N; Wang, L; Wang, Z; Xu, X; Yoshimura, R | 1 |
| Abbasi, M; Chitranshi, N; Chung, R; Dheer, Y; Graham, S; Gupta, V; Gupta, VB; Mirzaei, M; Vander Wall, R; You, Y | 1 |
| Jaehne, EJ; Lee, JJW; van den Buuse, M | 1 |
| Baron, JL; Duwaerts, CC; Goodsell, A; Maher, JJ; Mattis, AN; Pierce, AA; Siao, K | 1 |
| Barney, J; Hamad, OM; Hennig, B; Hoffman, JB; Morris, AJ; Petriello, MC; Thompson, B; Wahlang, B; Wang, C | 1 |
| Bischof, RJ; Clifton, VL; Gatford, KL; Giles, LC; Heinemann, GK; Hunter, DS; Kind, KL; Lien, YC; Liu, H; Lu, W; Owens, JA; Rabinowitz, JD; Simmons, RA; Wooldridge, AL | 1 |
| Azad, MAK; Huang, P; Liu, G; Ren, W; Teklebrh, T; Yan, W; Yin, Y; Zhou, X | 1 |
| Bedossa, P; Geys, L; Lijnen, HR; Roose, E; Scroyen, I; Vanhoorelbeke, K | 1 |
| de Paula Faria, D; de Vries, EFJ; Dierckx, RAJO; Doorduin, J; Langendijk, JA; Maas, B; Parente, A; Shoji, A; van Waarde, A; Zijlma, R | 1 |
| Alpini, G; Demieville, J; Francis, H; Hargrove, L; Kennedy, L; Stephenson, K; Thomson, J | 1 |
| Cherrington, NJ; Li, H; Toth, E | 1 |
| Kang, BH; Lee, WK; Min, BH; Park, JS; Shim, YJ | 1 |
| Beretta, L; Fallon, M; Gjuka, D; Harrison, SA; Ioannou, GN; Shen, H; Song, X; Stevenson, HL; Wang, J; Yoo, SY; Yoo, W | 1 |
| Buechler, C; Feder, S; Haberl, EM; Krautbauer, S; Liebisch, G; Pohl, R; Rein-Fischboeck, L; Schmid, V | 1 |
| Ansai, T; Fujiwara, T; Hiraoka, BY; Hoshino, T; Nakamura, S; Shioya, K; Suzuki, N; Yoshida, A; Yoshinari, N | 1 |
| Alberti, JM; Baloh, RH; Biris, N; Dorn, GW; Franco, A; Gavathiotis, E; Janetka, JW; Kitsis, RN; Knight, WC; Krezel, AM; Mochly-Rosen, D; Rocha, AG; Rumsey, JM; Townsend, RR; Zacharioudakis, E | 1 |
| Ashton, N; Borland, SJ; Canfield, AE; Eyre, HJ; Gilmore, A; Hyde, GD; Inkson, CA; Kalra, PA; Pond, E; Ponnusamy, A; Sinha, S; Taylor, RF | 1 |
| Arif, M; Bratt, JM; Chang, KY; Filosto, S; Franzi, LM; Goldkorn, T; Kenyon, NJ; Last, JA; Ott, SP; Rabowsky, M; Zeki, AA | 1 |
| Han, DH; Jo, YS; Kim, KH; Kim, SH; Lee, MS; Lee, YH | 1 |
| Cho, T; Mak, A; Uetrecht, J | 1 |
| Huttenlocher, A; Jain, S; Kabbage, M; Keller, NP; Knox, BP; Palmer, JM; Sekonyela, R | 1 |
| Columbano, A; Orrù, C; Perra, A; Szydlowska, M; Taguchi, K; Yamamoto, M; Zavattari, P | 1 |
| Cho, PJ; Jeon, TW; Jeong, TC; Jo, JJ; Ki, SH; Kim, KM; Kwon, OK; Lee, S; Lee, TH; Na, AY; Shrestha, R | 1 |
| Hasegawa, K; Itoh, H; Kanda, T; Kawabe, H; Kitahama, R; Komatsu, M; Kurokochi, A; Ono, T; Shigaki, S; Tokuyama, H; Urai, H; Wakino, S; Yukioka, H | 1 |
| Cao, Q; Ding, Y; Jiang, Y; Jin, L; Jing, M; Lu, J; Wu, C; Yang, L | 1 |
| Bian, XY; Fang, DQ; Jiang, XW; Li, LJ; Li, YT; Peng, CG; Shi, D; Wang, Q; Wu, JJ; Wu, WR; Xia, PC; Yang, LY; Ye, JZ; Ye, WC | 1 |
| Grayson, DR; Guidotti, A | 1 |
| Hong, W; Li, M; Liu, L; Ren, H; Shi, X; Wang, J; Xu, H; Xu, Y | 1 |
| Lavillette, D; Long, G; Xu, Y; Zhao, F; Zhong, J; Zou, G | 1 |
| Feng, J; Shen, G; Wang, Z; Xu, R | 1 |
| Bárcena, C; Caravia, XM; Durand, S; Fernández-García, MT; Freije, JMP; Garabaya, C; Kroemer, G; López-Otín, C; Mariño, G; Mayoral, P; Quirós, PM; Rodríguez, F | 1 |
| Huang, K; Liu, X; Mei, D; Niu, Z; Zhang, B | 1 |
| Chen, Q; Dai, W; Liu, H; Liu, J; Sun, Y; Zhao, F | 1 |
| Liong, EC; So, KF; Tipoe, GL; Wang, F; Xiao, J | 1 |
| Bárcena, C; Kroemer, G; López-Otín, C | 1 |
| Auwerx, J; Cialabrini, L; De Franco, F; de Seigneux, S; Gariani, K; Giacchè, N; Ivanisevic, J; Katsyuba, E; Legouis, D; Liscio, P; Matilainen, O; Mottis, A; Pellicciari, R; Raffaelli, N; Ryu, D; Schoonjans, K; Stokar-Regenscheit, N; van der Velpen, V; Zietak, M | 1 |
| Inaba, Y; Inoue, H; Kimura, K; Matsukawa, T; Matsumoto, M; Watanabe, H | 1 |
| Bacon, ER; Brinton, RD; Desai, MK; Mishra, A; Wang, Y; Yin, F | 1 |
| Le, G; Luo, T; Shi, Y; Sun, J; Wang, Y; Wu, G; Xu, Y; Yang, Y | 1 |
| Dong, Z; Duan, C; Kang, T; Li, Y; Lu, J; Tang, F; Wu, Y; Zhou, S | 1 |
| Bennek, E; Candels, LS; Elfers, C; Gassler, N; Heymann, F; Kilic, K; Mohs, A; Penders, J; Schneider, KM; Schneider, LB; Trautwein, C | 1 |
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| Cheng, L; Dai, RW; Luo, ZL; Ren, JD; Tang, LJ; Tian, FZ; Wang, T; Xiang, K | 1 |
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| Claudel, T; Hoefler, G; Jha, P; Knopf, A; Koefeler, H; Lackner, C; Mueller, M; Trauner, M | 1 |
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| Chen, T; Hong, YM; Qiu, LX; Su, WJ; Zhong, FJ; Zhuang, LL | 1 |
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| French, SW; Halsted, CH; Islam, MS; Keen, CL; Kharbanda, KK; Kim, K; LaSalle, JM; Le, A; Medici, V; Shibata, NM | 1 |
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| Chui, PC; Cunniff, JC; Fisher, FM; Flier, JS; Kharitonenkov, A; Lundasen, T; Maratos-Flier, E; Nasser, IA; Popov, Y; Schuppan, D | 1 |
| Eissenberg, JC; Florens, L; Gao, X; Herz, HM; Jackson, J; Morgan, M; Rickels, R; Shilatifard, A; Swanson, SK; Washburn, MP | 1 |
| de Luka, S; Jorgacevic, B; Mladenovic, D; Radosavljevic, T; Stevanovic, I; Veskovic, M | 1 |
| Arning, E; Blokhin, IO; Bottiglieri, T; Dayal, S; Erger, RA; Faraci, FM; Jensen, M; Lentz, SR; Stevens, JW | 1 |
| Calcagnotto, A; Cooper, TK; Perrone, CE; Richie, JP; Rogers, CJ; Sinha, I; Sinha, R; Turbitt, WJ | 1 |
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| Bohle, RM; Gemperlein, K; Haybaeck, J; Kessler, SM; Kiemer, AK; Müller, R; Simon, Y | 1 |
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| Chang, CJ; Liou, SS; Liu, IM; Tzeng, TF | 1 |
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| Jeon, S; Kwon, YH; Nam, Y; Park, YJ; Won, SB; Yoo, NY | 1 |
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| Choi, HJ; Jang, S; Jo, W; Kim, JK; Kim, KW; Lee, HJ; Ryu, JE; Son, WC; Woo, DC; Yu, ES | 1 |
| Cheng, YJ; Liou, SS; Liu, IM; Tzeng, TF; Tzeng, YC | 1 |
| Blakely, RD; McMeekin, AM; Moussa-Tooks, AB; Nackenoff, AG; Veenstra-VanderWeele, J | 1 |
| Fan, XX; Jiang, ZH; Leung, EL; Liu, L; Liu, ZQ; Lu, LL; Tin, VP; Wong, MP; Yao, XJ; Yau, LF; Zhou, YL | 1 |
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| Furuichi, Y; Kobayashi, Y; Kojima, M; Moriyasu, F; Nakamura, I; Ogawa, S; Oshiro, H; Sano, T; Sugimoto, K; Yoshida, K | 1 |
| Cappelletti, M; Divanovic, S; Dong, C; Giles, DA; Huppert, SS; Iwakura, Y; Moreno-Fernandez, ME; Shanmukhappa, SK; Stankiewicz, TE | 1 |
| Gao, T; Gong, J; Li, J; Ma, J; Mu, J; Ren, H; Wang, J; Xie, J; Yuan, B; Zheng, S; Zhu, P | 1 |
| Cho, EH; Choi, DH; Lee, EH; Lee, S; Li, YH; Seo, SR | 1 |
| Egger, M; Eggert, T; ElGindi, M; Felsher, DW; Greten, TF; Han, M; Heikenwalder, M; Jin, P; Kapoor, V; Kesarwala, AH; Kleiner, DE; Luo, J; Ma, C; McVicar, DW; Medina-Echeverz, J; Stroncek, DF; Terabe, M; Thornton, AM; Weber, A; Zhang, H | 1 |
| Harimoto, N; Ikegami, T; Itoh, S; Kimura, K; Maehara, Y; Okano, S; Shirabe, K; Takeishi, K; Uchiyama, H; Yoshizumi, T | 1 |
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| Chung, YC; Feierman, E; Kruyer, A; Norris, EH; Richards, A; Strickland, S; Yao, Y | 1 |
| Almansa, I; Benlloch-Navarro, S; López-Pedrajas, R; Miranda, M; Romero, FJ; Sánchez-Vallejo, V; Trachsel-Moncho, L | 1 |
| Choi, KC; Choi, SJ; Kim, B; Kim, JW; Lee, K; Lee, SH; Lim, CW; Park, S; Yun, H | 1 |
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| Beschin, A; De Baetselier, P; Devoogdt, N; Flamand, V; Muyldermans, S; Raes, G; Schoonooghe, S; Sparkes, A; Stijlemans, B; Van Ginderachter, JA; Zheng, F | 1 |
| Hashimoto, T; Kanematsu, Y; Kitazato, KT; Korai, M; Matsushita, N; Miyamoto, T; Nagahiro, S; Satomi, J; Shimada, K; Tada, Y | 1 |
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| Higuchi, T; Jahns, R; Jahns, V; Lapa, C; Maya, Y; Samnick, S; Schütz, C; Wakabayashi, H; Werner, RA; Zechmeister, C | 1 |
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| Jiang, W; Lin, Q; Wang, L; Zhang, Y; Zhao, C | 1 |
| Damgaard, RB; Elliott, PR; Komander, D; Maher, ER; Marco-Casanova, P; McHale, D; McKenzie, ANJ; Morgan, NV; Titheradge, HL; Walker, JA | 1 |
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| Bankstahl, JP; Bengel, FM; Thackeray, JT; Wang, Y; Wollert, KC | 1 |
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| Maher, JJ | 1 |
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| Arning, E; Bottiglieri, T; Cooke, JP; Dayal, S; Faraci, FM; Kimoto, M; Lentz, SR; Murry, DJ; Rodionov, RN | 1 |
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| Blair, IA; Gong, W; Huang, Y; Lorent, K; Mañoral-Mobias, R; Matthews, RP; Murray, IV; Pack, M | 1 |
| Brooling, J; dela Pena, A; Farrell, GC; Francisco, R; Hou, JY; Larter, CZ; Osvath, SR; Sedger, LM; Teoh, N; Williams, J; Yeh, MM; Zhang, RH | 1 |
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| Chen, Y; Dong, E; Grayson, DR; Guidotti, A; Kundakovic, M | 1 |
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| Brennan, LA; Cowell, T; Giblin, F; Kantorow, M; Lee, W | 1 |
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| Abrams, MT; Bhimnathwala, H; Chen, HY; Chen, Z; Conner, MW; Davide, JP; Diehl, RE; Ellis, MS; Gibbs, JB; Gopal-Truter, S; Greenberg, I; Koblan, KS; Kohl, NE; Kral, AM; Liu, D; Lobell, RB; Miller, PJ; Mosser, SD; O'Neill, TJ; Oliff, A; Omer, CA; Rands, E; Schaber, MD; Seeburger, G; Senderak, ET; Trumbauer, ME | 1 |
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25 review(s) available for methionine and Disease Models, Animal
| Article | Year |
|---|---|
A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Hepatocytes; Humans; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Transcriptome | 2022 |
Cystathionine β-synthase deficiency: Of mice and men.
Topics: Animals; Animals, Newborn; Cystathionine beta-Synthase; Disease Models, Animal; Genotype; Homocysteine; Homocystinuria; Humans; Male; Metabolism, Inborn Errors; Methionine; Mice; Mutation; Phenotype; Pyridoxine | 2017 |
Hyperhomocysteinemia and cardiovascular disease in animal model.
Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Risk Factors | 2018 |
Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights.
Topics: Animals; Choline Deficiency; Diet, Western; Disease Models, Animal; Humans; Methionine; Non-alcoholic Fatty Liver Disease | 2018 |
DNA Methylation in Animal Models of Psychosis.
Topics: Animals; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Methionine; Psychotic Disorders; Stress, Psychological | 2018 |
The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Dietary Supplements; Disease Models, Animal; DNA Methylation; Fasting; Fatty Liver; Folic Acid; Homocysteine; Humans; Liver; Metabolic Networks and Pathways; Methionine; Muscular Diseases; S-Adenosylmethionine | 2013 |
Vitamin B(12) metabolism during pregnancy and in embryonic mouse models.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Acyl Coenzyme A; Animals; Disease Models, Animal; Embryonic Development; Female; Homocysteine; Humans; Methionine; Methylmalonyl-CoA Mutase; Mice; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice.
Topics: Acetylcysteine; Amino Acids, Sulfur; Animals; Betaine; Cystathionine beta-Synthase; Diet; Dietary Supplements; Disease Models, Animal; Genotype; Homocystinuria; Humans; Metabolic Networks and Pathways; Methionine; Mice; Mice, Knockout; Mutation; Phenotype | 2016 |
Neuropathological and biochemical criteria to identify acquired Creutzfeldt-Jakob disease among presumed sporadic cases.
Topics: Animals; Brain; Codon; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Gene Knock-In Techniques; Genotype; Humans; Methionine; Mice; Mice, Transgenic; Phenotype; Prion Proteins; PrPC Proteins; PrPSc Proteins | 2016 |
Animal models of NASH: getting both pathology and metabolic context right.
Topics: Animals; Choline Deficiency; Diet, Atherogenic; Dietary Fats; Disease Models, Animal; Disease Progression; Fatty Liver; Genetic Predisposition to Disease; Hyperphagia; Intubation, Gastrointestinal; Liver; Methionine; Overnutrition; Phenotype; Reproducibility of Results | 2008 |
From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophrenia.
Topics: Animals; Brain; Cytosine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Evolution, Molecular; Humans; Methionine; Methyltransferases; Mice; Neurons; Reelin Protein; Schizophrenia | 2009 |
Animal models of non-alcoholic steatohepatitis: of mice and man.
Topics: Animals; Choline Deficiency; Dietary Fats; Disease Models, Animal; Fatty Liver; Humans; Liver; Methionine; Mice | 2010 |
Folate, alcohol, and liver disease.
Topics: Absorption; Alcohol Drinking; Animals; Antioxidants; Disease Models, Animal; Epigenesis, Genetic; Ethanol; Folic Acid; Folic Acid Deficiency; Gene Expression; Humans; Intestine, Small; Liver; Liver Diseases, Alcoholic; Methionine; Methylation | 2013 |
Folate deficiency, methionine metabolism, and alcoholic liver disease.
Topics: Animals; Disease Models, Animal; Folic Acid Deficiency; Humans; Liver Diseases, Alcoholic; Methionine; Swine, Miniature | 2002 |
Mechanisms of the atherogenic effects of elevated homocysteine in experimental models.
Topics: Animals; Arteriosclerosis; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Hyperhomocysteinemia; Methionine; Mice; Nitric Oxide; Oxidative Stress; Risk Factors | 2005 |
Mechanisms of homocysteine-induced atherothrombosis.
Topics: Animals; Apolipoproteins E; Apoptosis; Arginine; Atherosclerosis; Coronary Thrombosis; Cysteine; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Inflammation; Methionine; Mice; Models, Biological; Nitric Oxide; Oxidative Stress; Oxygen; Phenotype; Signal Transduction | 2005 |
Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse.
Topics: Animals; Antioxidants; Disease Models, Animal; Dwarfism; Female; Glutathione; Humans; Longevity; Male; Methionine; Mice; Models, Biological; Reverse Transcriptase Polymerase Chain Reaction; Sulfur; Time Factors | 2006 |
Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.
Topics: Animals; Betaine; Disease Models, Animal; Folic Acid; Humans; Liver Diseases, Alcoholic; Methionine; S-Adenosylmethionine | 2007 |
Adverse effects of excessive consumption of amino acids.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Cattle; Diet; Disease Models, Animal; Ethionine; Fenclonine; Glycine; Growth Disorders; Histidine; Humans; Methionine; Nerve Tissue Proteins; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonurias; Pneumonia, Atypical Interstitial, of Cattle; Serine; Stereoisomerism; Sulfhydryl Compounds; Tissue Distribution; Tryptophan; Tyrosine; Vitamin A | 1984 |
Disorders of homocysteine metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Amino Acid Metabolism, Inborn Errors; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Homocysteine; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Oxidoreductases | 1997 |
[Influence of amino acids on pancreatic functional activity].
Topics: Amylases; Animals; Arginine; Disease Models, Animal; Humans; Methionine; Pancreatitis; Rats; Rats, Wistar | 2000 |
Influence of dietary factors on the pancreatotoxicity of ethionine.
Topics: Acute Disease; Age Factors; Animals; Choline Deficiency; Diet; Disease Models, Animal; Enzyme Precursors; Ethionine; Female; Hemorrhage; Humans; Male; Methionine; Necrosis; Pancreas; Pancreatitis; Phosphatidylcholines; Sex Factors | 1976 |
Cobalamin-folate interrelations: a critical review.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central Nervous System; Deoxyuridine; Disease Models, Animal; Drug Interactions; Enzyme Activation; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Liver; Methionine; Methylmalonyl-CoA Mutase; Nitrous Oxide; Oxidation-Reduction; Pteroylpolyglutamic Acids; Purines; Serine; Tetrahydrofolates; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency | 1985 |
[Endogenous convulsants (review)].
Topics: Amino Acids; Animals; Carbolines; Cats; Cerebral Cortex; Convulsants; Cysteic Acid; Cysteine; Disease Models, Animal; Dogs; Estrogens; Folic Acid; Homocysteine; Kynurenine; Methionine; Mice; Neurotransmitter Agents; Prostaglandins; Pyridoxal Phosphate; Quinolinic Acid; Quinolinic Acids; Rats; Seizures; Spinal Cord | 1986 |
The fruit bat as an experimental model of the neuropathy of cobalamin deficiency.
Topics: Animals; Chiroptera; Disease Models, Animal; Fatty Acids; Folic Acid; Methionine; Nervous System Diseases; Neurotransmitter Agents; Vitamin B 12 Deficiency | 1987 |
1 trial(s) available for methionine and Disease Models, Animal
| Article | Year |
|---|---|
Oral-recombinant Methioninase in Combination With Rapamycin Eradicates Osteosarcoma of the Breast in a Patient-derived Orthotopic Xenograft Mouse Model.
Topics: Animals; Bone Neoplasms; Carbon-Sulfur Lyases; Disease Models, Animal; Heterografts; Methionine; Mice; Mice, Nude; Osteosarcoma; Recombinant Proteins; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2022 |
497 other study(ies) available for methionine and Disease Models, Animal
| Article | Year |
|---|---|
[Identification of
Topics: Animals; Carcinoma, Hepatocellular; Chromatography, Liquid; Disease Models, Animal; Inflammation; Liver; Liver Neoplasms; Mass Spectrometry; Methionine; Mice | 2021 |
Zonarol Protected Liver from Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in a Mouse Model.
Topics: Animals; Biomarkers; Choline Deficiency; Diet; Disease Models, Animal; Hepatocytes; Immunohistochemistry; Lipid Metabolism; Liver; Male; Methionine; Mice; Models, Biological; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Protective Agents; Sesquiterpenes; Signal Transduction | 2021 |
Notch-triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Endothelium; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III; Non-alcoholic Fatty Liver Disease | 2022 |
SU5, a new Auraptene analog with improved metabolic stability, ameliorates nonalcoholic fatty liver disease in methionine- and choline-deficient diet-fed db/db mice.
Topics: Animals; Choline; Coumarins; Diet; Disease Models, Animal; Down-Regulation; Half-Life; Humans; Lipid Metabolism; Liver; Methionine; Mice; Mice, Obese; Non-alcoholic Fatty Liver Disease; Rats; Receptors, Cytoplasmic and Nuclear; Tumor Necrosis Factor-alpha; Up-Regulation | 2022 |
Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.
Topics: Animals; Choline; Diet, High-Fat; Dietary Carbohydrates; Dietary Fats; Disease Models, Animal; Galectin 3; Gene Expression Profiling; Lipid Droplets; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Sus scrofa | 2022 |
A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice.
Topics: Amino Acids; Animals; Bipolar Disorder; Disease Models, Animal; Drug Administration Schedule; Homocysteine; Male; Methionine; Mice; Open Field Test; Up-Regulation | 2022 |
Sitagliptin Attenuates the Cognitive Deficits in L-Methionine-Induced Vascular Dementia in Rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cognition; Dementia, Vascular; Disease Models, Animal; Hippocampus; Male; Maze Learning; Methionine; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Sitagliptin Phosphate | 2022 |
Comparison of L- and D-Amino Acids for Bacterial Imaging in Lung Infection Mouse Model.
Topics: Amino Acids; Animals; Disease Models, Animal; Escherichia coli; Fluorodeoxyglucose F18; Lung; Methionine; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution | 2022 |
HPS protects the liver against steatosis, cell death, inflammation, and fibrosis in mice with steatohepatitis.
Topics: Animals; Apoptosis; Diet, High-Fat; Disease Models, Animal; Humans; Inflammation; Insulin Resistance; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease | 2022 |
L-Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis, and inflammation in rats.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Fibrosis; Fructose; Inflammation; Lipid Metabolism; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; Sirtuin 1 | 2022 |
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis.
Topics: Animals; Annexin A1; Disease Models, Animal; Fibrosis; Inflammation; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
S-adenosyl methionine improves motor co-ordination with reduced oxidative stress, dopaminergic neuronal loss, and DNA methylation in the brain striatum of 6-hydroxydopamine-induced neurodegeneration in rats.
Topics: Animals; Antioxidants; Brain; Disease Models, Animal; DNA Methylation; Dopamine; Glutathione; Methionine; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Oxidopamine; Parkinson Disease; Rats; Substantia Nigra | 2023 |
Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; CA-19-9 Antigen; Carbon-Sulfur Lyases; Disease Models, Animal; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Methionine; Mice; Mice, Nude; Oxaliplatin; Pancreatic Neoplasms; Xenograft Model Antitumor Assays | 2022 |
The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drugs, Chinese Herbal; Fibrosis; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease | 2022 |
Indole supplementation ameliorates MCD-induced NASH in mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; Indoles; Inflammation; Lipopolysaccharides; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress.
Topics: Animals; Choline; Cytoplasmic Dyneins; Diet; Disease Models, Animal; Dyneins; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2022 |
Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Creatine; Curcumin; Disease Models, Animal; Gastrointestinal Microbiome; Levodopa; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; Neuroprotective Agents; Parkinson Disease; RNA, Ribosomal, 16S; Sarcosine | 2022 |
CCN6 improves hepatic steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis.
Topics: Animals; CCN Intercellular Signaling Proteins; Diet; Disease Models, Animal; Humans; Inflammation; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis.
Topics: Animals; Choline; Diet; Disease Models, Animal; Humans; Inflammation; Lipids; Liver; Liver Cirrhosis; Melatonin; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation.
Topics: Animals; Choline; Disease Models, Animal; Intestines; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Neuron-Glial Antigen 2 Participates in Liver Fibrosis via Regulating the Differentiation of Bone Marrow Mesenchymal Stem Cell to Myofibroblast.
Topics: Animals; Antigens; Cell Differentiation; Choline; Disease Models, Animal; Humans; Liver; Liver Cirrhosis; Mesenchymal Stem Cells; Methionine; Mice; Myofibroblasts; Neurons; RNA, Small Interfering | 2023 |
Lower adiposity does not protect beta-2 syntrophin null mice from hepatic steatosis and inflammation in experimental non-alcoholic steatohepatitis.
Topics: Adiposity; Animals; Cholesterol Esters; Choline; Disease Models, Animal; Fatty Acid Synthases; Fatty Acids; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Obesity | 2023 |
Quercetin modulates the liver metabolic profile in a chronic unpredictable mild stress rat model based on metabolomics technology.
Topics: Animals; Depression; Disease Models, Animal; Liver Diseases; Male; Metabolome; Metabolomics; Methionine; Quercetin; Rats; Stress, Psychological | 2023 |
Thermoneutral housing shapes hepatic inflammation and damage in mouse models of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Choline; Disease Models, Animal; Housing; Inflammation; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Adenylyl-Sulfate Kinase (Met14)-Dependent Cysteine and Methionine Biosynthesis Pathways Contribute Distinctively to Pathobiological Processes in Cryptococcus neoformans.
Topics: Animals; Antifungal Agents; Capsules; Cryptococcosis; Cryptococcus neoformans; Cysteine; Disease Models, Animal; Mammals; Melanins; Methionine; Mice; Sulfates; Sulfur; Virulence Factors | 2023 |
Chrysin and its nanoliposome ameliorated non-alcoholic steatohepatitis via inhibiting TLR4 signalling pathway.
Topics: Animals; Choline; Diet; Disease Models, Animal; Flavonoids; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Toll-Like Receptor 4 | 2023 |
Gut Protective Effect from D-Methionine or Butyric Acid against DSS and Carrageenan-Induced Ulcerative Colitis.
Topics: Animals; Butyric Acid; Carrageenan; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Inflammation; Inflammatory Bowel Diseases; Methionine; Mice; Mice, Inbred C57BL; Racemethionine | 2023 |
MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats.
Topics: Animals; Choline; Diet; Disease Models, Animal; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Racemethionine; Rats; Rats, Wistar | 2023 |
Endothelial autophagy is not required for liver regeneration after partial hepatectomy in mice with fatty liver.
Topics: Animals; Autophagy; Choline; Diet, High-Fat; Disease Models, Animal; Endothelial Cells; Focal Nodular Hyperplasia; Hepatectomy; Liver; Liver Regeneration; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice.
Topics: Animals; Choline; Disease Models, Animal; Inflammation; Isotope Labeling; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proteomics | 2023 |
Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fibrosis; Interleukin-8; Liver; Liver Cirrhosis; Liver Neoplasms; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Choline; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Humans; Inflammasomes; Intracellular Signaling Peptides and Proteins; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2023 |
CARD9 deficiency aggravated nonalcoholic steatohepatitis in mice through increasing inflammatory response.
Topics: Animals; Choline; Diet, High-Fat; Disease Models, Animal; Liver Cirrhosis; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2024 |
Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating L-arginine production.
Topics: Animals; Choline; Diet, High-Fat; Disease Models, Animal; Hepatitis; Humans; Inflammation; Lactobacillus plantarum; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine-restricted diet or enzyme replacement therapy.
Topics: Animals; Behavior, Animal; Body Composition; Cystathionine beta-Synthase; Disease Models, Animal; Enzyme Replacement Therapy; Homocystinuria; Humans; Methionine; Mice; Mice, Transgenic | 2019 |
Arterio-venous metabolomics exploration reveals major changes across liver and intestine in the obese Yucatan minipig.
Topics: Animals; Arteries; Disease Models, Animal; Fatty Acids; Female; Humans; Insulin; Intestines; Liver; Metabolomics; Methionine; Obesity; Swine; Swine, Miniature; Threonine; Veins | 2019 |
Study of Methionine Choline Deficient Diet-Induced Steatosis in Mice Using Endogenous Fluorescence Spectroscopy.
Topics: Adipose Tissue; Animals; Area Under Curve; Choline Deficiency; Discriminant Analysis; Disease Models, Animal; Disease Progression; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Principal Component Analysis; ROC Curve; Sensitivity and Specificity; Severity of Illness Index; Spectrometry, Fluorescence | 2019 |
Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities.
Topics: Actins; Animal Experimentation; Animals; Calcium-Binding Proteins; Ceramides; Cholesterol; Choline Deficiency; Diet; Disease Models, Animal; Gene Expression Regulation; Interleukin-6; Liver; Lysophosphatidylcholines; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Receptors, G-Protein-Coupled; Sphingomyelins; Transforming Growth Factor beta; Triglycerides | 2019 |
L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet.
Topics: Animals; Carnitine; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; Disease Progression; Heart Diseases; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Reactive Oxygen Species | 2020 |
Postconditioning Accelerates Myocardial Inflammatory Resolution Demonstrated by
Topics: Animals; Autoradiography; Carbon Radioisotopes; Disease Models, Animal; Feasibility Studies; Ischemic Postconditioning; Male; Methionine; Molecular Imaging; Myocardial Infarction; Myocardial Reperfusion Injury; Myocarditis; Radiopharmaceuticals; Rats, Wistar; Technetium Tc 99m Sestamibi; Thallium Radioisotopes; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2019 |
Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease.
Topics: Animals; Antagomirs; beta Catenin; Choline; Disease Models, Animal; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Humans; Low Density Lipoprotein Receptor-Related Protein-6; Methionine; Mice; MicroRNAs; Non-alcoholic Fatty Liver Disease; Wnt Signaling Pathway | 2019 |
Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.
Topics: Animals; Bone Marrow Transplantation; Cell Lineage; Disease Models, Animal; Doxycycline; Epigenesis, Genetic; Erythroid Cells; Female; Granulocytes; Histones; Leukemia, T-Cell; Lysine; Male; Methionine; Methylation; Mice; Mice, Transgenic; Mouse Embryonic Stem Cells; Mutation; Signal Transduction; Survival Analysis; T-Lymphocytes; Teratoma | 2019 |
Downregulation of GNAI3 Promotes the Pathogenesis of Methionine/Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease.
Topics: Animals; Choline; Disease Models, Animal; Down-Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction.
Topics: Animals; Animals, Outbred Strains; Benzimidazoles; Cardiotonic Agents; Disease Models, Animal; Endocardium; Endothelium, Vascular; Isoproterenol; Male; Methionine; Morpholines; Myocardial Ischemia; Rats; Treatment Outcome | 2019 |
Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Choline Deficiency; Curcumin; Disease Models, Animal; Endoplasmic Reticulum Stress; Glycosylation; Hexosamines; Inflammation Mediators; Liver; Male; Methionine; Mice, Inbred C57BL; N-Acetylglucosaminyltransferases; NF-kappa B; Non-alcoholic Fatty Liver Disease; Signal Transduction; Sirtuin 1; Superoxide Dismutase-1 | 2019 |
Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis.
Topics: Animals; Choline Deficiency; Collagen Type I; Cyclophilins; Diet; Disease Models, Animal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Male; Methionine; Mice; Molecular Targeted Therapy; Non-alcoholic Fatty Liver Disease | 2019 |
Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet.
Topics: Animals; Choline; Diet; Disease Models, Animal; Hepatectomy; Lipid Metabolism; Liver; Liver Neoplasms; Male; Metabolomics; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
Multi-technique comparison of atherogenic and MCD NASH models highlights changes in sphingolipid metabolism.
Topics: Animals; Atherosclerosis; Choline; Diet; Diet, Atherogenic; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Lipidomics; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Phosphatidylcholines; Sphingolipids | 2019 |
Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes.
Topics: Amino Acids, Aromatic; Animals; Choline; Chromatography; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Hepatolenticular Degeneration; Humans; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolomics; Methionine; Phenotype | 2019 |
Effect of Methionine Diet on Metabolic and Histopathological Changes of Rat Hippocampus.
Topics: Animals; Disease Models, Animal; Hippocampus; Hyperhomocysteinemia; Male; Metabolome; Methionine; Organ Size; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Wistar | 2019 |
ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation.
Topics: Adult; Animals; beta-Arrestin 1; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Disease Progression; Female; Golgi Apparatus; Growth Differentiation Factor 15; Humans; Lipogenesis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Non-alcoholic Fatty Liver Disease; Signal Transduction; Young Adult | 2020 |
Edaravone protects from memory impairment induced by chronic L-methionine administration.
Topics: Animals; Antioxidants; Dementia, Vascular; Disease Models, Animal; Edaravone; Free Radical Scavengers; Hippocampus; Hyperhomocysteinemia; Male; Maze Learning; Memory Disorders; Methionine; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar | 2020 |
Role of hepatic neuropeptide Y-Y1 receptors in a methionine-choline-deficient model of non-alcoholic steatohepatitis.
Topics: Animals; Blotting, Western; Choline Deficiency; Disease Models, Animal; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Receptors, Neuropeptide Y; Triglycerides | 2020 |
Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice.
Topics: Anemia, Iron-Deficiency; Animals; Basic Helix-Loop-Helix Transcription Factors; Diet; Disease Models, Animal; Female; Gene Expression Regulation; Hemochromatosis; Hemochromatosis Protein; Homeostasis; Homozygote; Humans; Intestinal Mucosa; Iron; Liver; Male; Methionine; Mice; Mice, Knockout; Mutation; Nucleotidases; Organoids; Signal Transduction; Sulfur | 2020 |
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Topics: Animals; Cell Proliferation; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Epigenesis, Genetic; HEK293 Cells; Histones; Humans; Methionine; Methylation; Mice, Inbred C57BL; Mice, Knockout; Multiple Sclerosis; Th17 Cells | 2020 |
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly.
Topics: Adult; Animals; Choline; Disease Models, Animal; Female; Glutaminase; Hepatocytes; Humans; Lipid Metabolism; Lipoproteins, VLDL; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phospholipids; Triglycerides | 2020 |
Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis.
Topics: Animal Feed; Animals; Body Weight; Choline; Diet; Disease Models, Animal; Female; Hepatic Stellate Cells; Humans; Inflammation; Insulin Resistance; Liver; Liver Cirrhosis; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphorylation; Placenta; Placental Extracts; Pregnancy; Reactive Oxygen Species; Smad Proteins | 2020 |
Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes.
Topics: Animals; Autophagy; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet, Protein-Restricted; Disease Models, Animal; Female; Kidney; Male; Mechanistic Target of Rapamycin Complex 1; Methionine; Obesity; Rats; Rats, Wistar | 2020 |
Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4α-dependent very low-density lipoprotein.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Flavonoids; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Lipoproteins, VLDL; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Protein Kinase C; Secretory Pathway; Signal Transduction; Treatment Outcome | 2020 |
Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Gene Expression; Gene Knockout Techniques; Glucagon-Like Peptide 1; Inflammation; Intestinal Mucosa; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Permeability; Protein Tyrosine Phosphatase, Non-Receptor Type 1; RAW 264.7 Cells | 2020 |
Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice.
Topics: Animals; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Non-alcoholic Fatty Liver Disease | 2020 |
Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome.
Topics: Animals; Caspase 1; Choline; Diet; Disease Models, Animal; DNA, Mitochondrial; Gene Expression Regulation; Injections, Intraperitoneal; Interleukin-1beta; Iridoid Glucosides; Liver; Macrophages; Methionine; Mice; Mitochondria, Liver; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Treatment Outcome | 2020 |
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
Topics: Adenosine; Animals; Carbon; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Flavins; Guanidine; Inflammation; Liver; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Nucleotides; Purinergic P1 Receptor Antagonists; Thymidine | 2020 |
Resveratrol prevents liver damage in MCD-induced steatohepatitis mice by promoting SIGIRR gene transcription.
Topics: Alanine Transaminase; Animals; Antioxidants; Choline Deficiency; Disease Models, Animal; Hepatocytes; Humans; Interleukin-1beta; Interleukin-6; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Receptors, Interleukin-1; Resveratrol; Toll-Like Receptors; Transcription, Genetic; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2020 |
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.
Topics: Animals; Arachidonate 12-Lipoxygenase; Choline; Choline Deficiency; Diet; Disease Models, Animal; Hepatic Stellate Cells; Isoenzymes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
Maternal Hyperhomocysteinemia Induces Neuroinflammation and Neuronal Death in the Rat Offspring Cortex.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Caspase 3; Cerebral Cortex; Disease Models, Animal; Female; Hyperhomocysteinemia; Inflammation; Interleukin-1beta; Interleukin-6; Methionine; Neuroglia; Neurons; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pregnancy Complications; Rats; Tumor Necrosis Factor-alpha | 2020 |
Citrus reticulata Blanco peel extract ameliorates hepatic steatosis, oxidative stress and inflammation in HF and MCD diet-induced NASH C57BL/6 J mice.
Topics: Animals; Choline; Citrus; Diet, High-Fat; Disease Models, Animal; Fruit; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-E2 Transcription Factor; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Plant Extracts | 2020 |
MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Cells, Cultured; Choline; Circadian Rhythm; Diet; Disease Models, Animal; Early Growth Response Transcription Factors; Fibrosis; Hepatocytes; Kruppel-Like Transcription Factors; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2020 |
Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis.
Topics: Animals; Biomarkers; Brain; Disease Models, Animal; Female; Humans; Metabolome; Metabolomics; Methionine; Mice; Pregnancy; Prenatal Nutritional Physiological Phenomena; Schizophrenia; Transcriptome | 2020 |
Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model.
Topics: Adaptor Proteins, Signal Transducing; Administration, Oral; Animals; Antibodies, Monoclonal, Humanized; Antigens, Neoplasm; Apoptosis; Carbon-Sulfur Lyases; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Methionine; Mice; Pancreatic Neoplasms; Receptors, TNF-Related Apoptosis-Inducing Ligand; Recombinant Proteins | 2020 |
Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD.
Topics: Animals; Betaine; Choline; Collagen; Diet; Dietary Supplements; Disease Models, Animal; Hepatocytes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
A Lipid-Based Nanocarrier Containing Active Vitamin D
Topics: Administration, Oral; Animals; Caco-2 Cells; Calcitriol; Cell Culture Techniques; Coculture Techniques; Disease Models, Animal; Drug Carriers; Gastrointestinal Microbiome; Hepatitis; Humans; Hypercalcemia; Intestinal Mucosa; Lipids; Lipopolysaccharides; Liver; Male; Methionine; Mice; Nanoparticles; Non-alcoholic Fatty Liver Disease; Pathogen-Associated Molecular Pattern Molecules; Permeability; RAW 264.7 Cells | 2020 |
Automated thermal imaging for the detection of fatty liver disease.
Topics: Algorithms; Animals; Automation; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Female; Humans; Image Processing, Computer-Assisted; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Thermography; Ultrasonography | 2020 |
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis
Topics: AMP-Activated Protein Kinases; Animals; Cholic Acids; Disease Models, Animal; Glucose; Homeostasis; Humans; Lipid Metabolism; Lipids; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; TOR Serine-Threonine Kinases | 2020 |
Live Confocal Imaging as a Novel Tool to Assess Liver Quality: Insights From a Murine Model.
Topics: Animals; Biopsy; Choline Deficiency; Cold Ischemia; Disease Models, Animal; Fatty Liver, Alcoholic; Liver; Male; Methionine; Mice, Inbred C57BL; Microscopy, Confocal; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; Reperfusion; Reperfusion Injury; Time Factors; Tissue Survival; Warm Ischemia | 2020 |
Plasma lipoprotein profile from nonalcoholic steatohepatitis model rats.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Choline Deficiency; Chylomicrons; Diet; Disease Models, Animal; Eating; Insulin; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Particle Size; Rats; Rats, Sprague-Dawley; Triglycerides | 2020 |
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Deficiency; Diethylnitrosamine; Disease Models, Animal; Humans; Lipidomics; Lipids; Lipogenesis; Liver; Liver Cirrhosis; Liver Neoplasms; Lysophosphatidylcholines; Male; Mass Spectrometry; Methionine; Mice; Mice, Inbred C3H; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2020 |
Associations between serum trace elements and inflammation in two animal models of nonalcoholic fatty liver disease.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Rats, Zucker; Trace Elements | 2020 |
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.
Topics: Amino Acids; Animal Feed; Animals; Apoptosis; Body Weight; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Humans; Inflammation; Insulin-Like Growth Factor I; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Organ Size; Phosphorylation; RNA; Soybean Oil; Sulfotransferases; Trans Fatty Acids | 2020 |
ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice.
Topics: Adipocytes; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Choline Deficiency; Chromatography, Liquid; Disease Models, Animal; Exosomes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Tandem Mass Spectrometry | 2021 |
Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet.
Topics: Alkaline Phosphatase; Alleles; Animals; Choline; Choline Deficiency; Diet; Diet, High-Fat; Disease Models, Animal; Enzyme Activation; Fatty Liver; Methionine; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; PPAR alpha; Proto-Oncogene Proteins c-akt; Signal Transduction | 2020 |
A Mineralocorticoid Receptor Deficiency in Myeloid Cells Reduces Liver Steatosis by Impairing Activation of CD8
Topics: Adaptive Immunity; Animals; CD8-Positive T-Lymphocytes; Choline Deficiency; Diet; Disease Models, Animal; Female; Hepatitis; Inflammation; Liver Cirrhosis; Lymphocyte Activation; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; Non-alcoholic Fatty Liver Disease; Receptors, Mineralocorticoid | 2020 |
Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase.
Topics: Administration, Oral; Aldehyde Oxidase; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Hydralazine; Lipid Droplets; Liver; Male; Methionine; Niacinamide; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; S-Adenosylmethionine; Triglycerides | 2021 |
Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
Topics: Adenosylhomocysteinase; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Folic Acid; Gene Expression Regulation, Enzymologic; Glycine Hydroxymethyltransferase; Homocysteine; Homocystinuria; Humans; Liver; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Polyamines | 2021 |
Visfatin exacerbates hepatic inflammation and fibrosis in a methionine-choline-deficient diet mouse model.
Topics: Adipokines; Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Nicotinamide Phosphoribosyltransferase; Non-alcoholic Fatty Liver Disease | 2021 |
Therapeutic potential of puerarin against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis determined by combination of
Topics: Animals; Choline; Diet; Disease Models, Animal; Genes, rRNA; Isoflavones; Liver; Magnetic Resonance Spectroscopy; Metabolomics; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; RNA, Ribosomal, 16S | 2021 |
SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH).
Topics: Animals; Anti-Inflammatory Agents; Choline; Cinnamates; Depsides; Disease Models, Animal; Liver; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Non-alcoholic Fatty Liver Disease; PPAR alpha; Rosmarinic Acid; Sirtuin 1 | 2022 |
BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization.
Topics: Adenoviridae; Animals; Cell Differentiation; Choline; Cytokines; Diet; Disease Models, Animal; Gene Expression Regulation; Genetic Vectors; Growth Differentiation Factor 2; Humans; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; NF-kappa B; Non-alcoholic Fatty Liver Disease; RAW 264.7 Cells; Th1 Cells | 2021 |
Hepatocyte-specific deletion of Nlrp6 in mice exacerbates the development of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Hepatocytes; Humans; Intracellular Signaling Peptides and Proteins; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Receptors, Cell Surface | 2021 |
High Methionine Diet-Induced Alzheimer's Disease like Symptoms Are Accompanied by 5-Methylcytosine Elevated Levels in the Brain.
Topics: 5-Methylcytosine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Diet; Disease Models, Animal; Maze Learning; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2021 |
Hyperhomocysteinemia increases susceptibility to cortical spreading depression associated with photophobia, mechanical allodynia, and anxiety in rats.
Topics: Animals; Anxiety; Behavior, Animal; Cortical Excitability; Cortical Spreading Depression; Disease Models, Animal; Female; Hyperalgesia; Hyperhomocysteinemia; Male; Methionine; Migraine with Aura; Photophobia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Somatosensory Cortex | 2021 |
Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney.
Topics: Animals; Caloric Restriction; Cell Cycle; Cell Proliferation; Disease Models, Animal; Female; Gene Expression; Homeodomain Proteins; Malnutrition; Mechanistic Target of Rapamycin Complex 1; Metabolomics; Methionine; Mice; Mice, Transgenic; Nephrons; Organ Culture Techniques; Pregnancy; RNA-Seq; RNA, Messenger; Signal Transduction; Stem Cells; Transcription Factors; Tuberous Sclerosis Complex 1 Protein | 2021 |
Soyasaponin A
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Choline Deficiency; Colon; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Saponins | 2021 |
[Parathyroid hormone-related protein aggravates nonalcoholic fatty liver disease induced by methionine choline-deficient diet in mice].
Topics: Animals; Choline; Diet; Disease Models, Animal; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Parathyroid Hormone-Related Protein | 2021 |
Clusters of Ultrasound Scattering Parameters for the Classification of Steatotic and Normal Livers.
Topics: Animals; Disease Models, Animal; Fatty Liver; Liver; Methionine; Rats; Ultrasonography | 2021 |
Network pharmacology-based identification of significant pathway for protection of Yinhuang granule in a mice model of metabolic-associated fatty liver disease.
Topics: Animals; Diet; Disease Models, Animal; Drugs, Chinese Herbal; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2021 |
Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Diet; Disease Models, Animal; Fast Foods; Leukocytes, Mononuclear; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphorylation; Protective Agents; Shc Signaling Adaptor Proteins; Signal Transduction; Therapeutics; Ubiquinone | 2021 |
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways.
Topics: Amino Acids; Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Signal Transduction | 2021 |
Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice.
Topics: Adenoviridae; Adipose Tissue; Alanine Transaminase; Animals; Choline Deficiency; Collagen Type I; Collagen Type III; Diet; Disease Models, Animal; Down-Regulation; Eye Proteins; Fatty Liver; Injections, Intramuscular; Interleukin-1beta; Interleukin-6; Kupffer Cells; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nerve Growth Factors; Oxidative Stress; PPAR gamma; Protease Inhibitors; RNA, Messenger; Serpins; Tumor Necrosis Factor-alpha; Up-Regulation | 2017 |
Monocytes, endoplasmic reticulum stress and metabolomics in dogs with multiple organ dysfunction syndrome treated by continuous venovenous hemodiafiltration.
Topics: Animals; Caspase 12; Cell Survival; Disease Models, Animal; Dogs; Endoplasmic Reticulum Stress; Gene Expression Regulation; Hemodiafiltration; Heparin; Human Umbilical Vein Endothelial Cells; Humans; Male; MAP Kinase Kinase 4; Metabolomics; Methionine; Monocytes; Multiple Organ Failure; Ornithine; Proline; Random Allocation; Transcription Factor CHOP | 2017 |
Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Gastrointestinal Microbiome; Gene Expression Profiling; Liver; Male; Maternal Nutritional Physiological Phenomena; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Overnutrition; Pregnancy; Prenatal Exposure Delayed Effects | 2017 |
Hyperpolarized
Topics: Animals; Ascorbic Acid; Carbon-13 Magnetic Resonance Spectroscopy; Choline Deficiency; Dehydroascorbic Acid; Diet; Disease Models, Animal; Lipid Metabolism; Liver; Magnetic Resonance Imaging; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2017 |
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Topics: Amino Acid Oxidoreductases; Animals; Cell Proliferation; Cell Transdifferentiation; Cells, Cultured; Choline Deficiency; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Induction; Extracellular Matrix; Forkhead Box Protein O1; Genetic Predisposition to Disease; Hepatic Stellate Cells; Hepatocytes; Humans; Insulin Resistance; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Phenotype; Receptor, Insulin; Signal Transduction | 2017 |
Farnesyltransferase inhibitor FTI-277 inhibits PD-L1 expression on septic spleen lymphocytes and promotes spleen lymphocyte activation.
Topics: Animals; B7-H1 Antigen; Cecum; Cells, Cultured; Disease Models, Animal; Farnesyltranstransferase; Humans; Lymphocyte Activation; Lymphocytes; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Programmed Cell Death 1 Receptor; Sepsis; Signal Transduction; Spleen | 2017 |
Methionine restriction on oxidative stress and immune response in dss-induced colitis mice.
Topics: Animals; Biomarkers; Catalase; Colitis; Dextran Sulfate; Disease Models, Animal; Immunity; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Methionine; Mice; NF-kappa B; Oxidative Stress; Peroxidase; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2017 |
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
Topics: Activating Transcription Factor 4; AMP-Activated Protein Kinases; Animals; Autophagy; Carbon Monoxide; Choline Deficiency; Disease Models, Animal; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Fatty Liver; Gene Expression Regulation; Hepatocytes; Liver; Male; Mechanistic Target of Rapamycin Complex 1; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Nuclear Proteins; Organometallic Compounds; Peroxidases; Primary Cell Culture; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction | 2017 |
Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide.
Topics: Animals; Blotting, Western; Cholera; Disease Models, Animal; Drosophila melanogaster; Fluorescent Antibody Technique; Host-Pathogen Interactions; Methionine; Rabbits; Vibrio cholerae; Virulence | 2017 |
Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Intestines; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oligosaccharides; Prebiotics | 2017 |
Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.
Topics: Animals; Biomarkers; Choline Deficiency; Cytokine Receptor gp130; Dietary Supplements; Disease Models, Animal; Humans; Inflammation; Interleukin-6; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Non-alcoholic Fatty Liver Disease | 2017 |
Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.
Topics: Animals; Carbon Radioisotopes; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Female; Isotope Labeling; Methionine; Mice, Inbred CBA; Positron-Emission Tomography; Staphylococcal Infections; Staphylococcus aureus | 2017 |
Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits.
Topics: Animals; Antipsychotic Agents; Basic Helix-Loop-Helix Transcription Factors; CA1 Region, Hippocampal; Clozapine; Developmental Disabilities; Disease Models, Animal; Female; Folic Acid; Haloperidol; Humans; Male; Methionine; Mice; Neurogenesis; Neuronal Plasticity; One-Carbon Group Transferases; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Schizophrenia; Stereotyped Behavior; Tetrahydrofolates | 2018 |
Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin.
Topics: Aged; Aged, 80 and over; Animals; Disease Models, Animal; Fibrinolysin; Fibrinolytic Agents; Glaucoma; Humans; Methionine; Mice; Neuropeptides; Neuroserpin; Oxidation-Reduction; Rats; Retina; Serine Proteinase Inhibitors; Serpins | 2017 |
Interaction of Brain-Derived Neurotrophic Factor Val66Met genotype and history of stress in regulation of prepulse inhibition in mice.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Apomorphine; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Genotype; Humans; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Polymorphism, Genetic; Prepulse Inhibition; Stress, Psychological; Valine | 2018 |
CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
Topics: Adipose Tissue; Animals; CD18 Antigens; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Hepatocytes; Immunity, Innate; Inflammation; Leukocytes; Lipase; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mutation; Oxygen; Peroxidase; Triglycerides | 2017 |
Editor's Highlight: PCB126 Exposure Increases Risk for Peripheral Vascular Diseases in a Liver Injury Mouse Model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Disease Models, Animal; Energy Metabolism; Environmental Pollutants; Gene Expression Regulation; Inflammation Mediators; Liver; Liver Cirrhosis; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Peripheral Vascular Diseases; Polychlorinated Biphenyls | 2017 |
Late-gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGR.
Topics: Animals; Cobalt; Dermatitis; Dietary Supplements; Disease Models, Animal; DNA Methylation; Female; Fetal Growth Retardation; Folic Acid; Gestational Age; Hypersensitivity; Immunoglobulin E; Mast Cells; Methionine; Ovalbumin; Placenta; Pregnancy; Prenatal Exposure Delayed Effects; Pyroglyphidae; Sheep, Domestic; Skin; Sulfur | 2018 |
Role of ADAMTS13 in diet-induced liver steatosis.
Topics: ADAMTS13 Protein; Animals; Body Weight; CD36 Antigens; Choline Deficiency; Diet; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Tissue Inhibitor of Metalloproteinase-1; Triglycerides; von Willebrand Factor | 2017 |
PET Imaging with S-[
Topics: Animals; Brain; Cysteine; Disease Models, Animal; Glioma; Inflammation; Kinetics; Male; Methionine; Positron-Emission Tomography; Rats, Wistar; Tumor Burden | 2018 |
Asking the Right Questions With Animal Models: Methionine- and Choline-Deficient Model in Predicting Adverse Drug Reactions in Human NASH.
Topics: Animals; Biological Transport; Choline Deficiency; Cytochrome P-450 Enzyme System; Diet; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Humans; Methionine; Non-alcoholic Fatty Liver Disease; Pharmaceutical Preparations; Predictive Value of Tests; Tissue Distribution | 2018 |
Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Clusterin; Diet; Disease Models, Animal; Hepatocytes; Liver; Male; Methionine; Mice; Mice, Transgenic; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; RNA, Messenger; Up-Regulation | 2018 |
Fatty acids in non-alcoholic steatohepatitis: Focus on pentadecanoic acid.
Topics: Animals; Choline; Choline Deficiency; Disease Models, Animal; Fatty Acids; Hepatocytes; Humans; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Triglycerides | 2017 |
Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model.
Topics: Adipocytes; Adiponectin; Adiposity; Animals; Body Weight; Calcium-Binding Proteins; Cell Size; Choline Deficiency; Diet, Atherogenic; Disease Models, Animal; Feeding Behavior; Inflammation; Lipase; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Membrane Proteins; Methionine; Mice; Mice, Knockout; Muscle Proteins; Muscle, Skeletal; Myostatin; Non-alcoholic Fatty Liver Disease; Organ Size; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Triglycerides | 2018 |
Porphyromonas gingivalis hydrogen sulfide enhances methyl mercaptan-induced pathogenicity in mouse abscess formation.
Topics: Abscess; Animals; Bacterial Proteins; Bacteroidaceae Infections; Carbon-Sulfur Lyases; Cysteine; Disease Models, Animal; Female; Gene Deletion; Hydrogen Sulfide; Methionine; Mice, Inbred BALB C; Porphyromonas gingivalis; Sulfhydryl Compounds; Virulence | 2018 |
MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A.
Topics: Amino Acid Substitution; Animals; Arginine; Axons; Charcot-Marie-Tooth Disease; Disease Models, Animal; Drug Design; Glutamine; GTP Phosphohydrolases; Humans; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Diseases; Mitochondrial Proteins; Oligopeptides; Phosphorylation; Protein Kinases; Sciatic Nerve; Small Molecule Libraries; Threonine | 2018 |
FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis.
Topics: alpha-Galactosidase; Animals; Apoptosis; Cattle; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Humans; Male; Methionine; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteogenesis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Renal Insufficiency, Chronic; Signal Transduction; Vascular Calcification | 2018 |
Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.
Topics: Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Disease Models, Animal; Enzyme Inhibitors; Eosinophils; Epithelial Cells; Farnesyltranstransferase; Humans; Inflammation; Lung; Male; Methionine; Mice; Mice, Inbred BALB C; Ovalbumin; Polyisoprenyl Phosphates; ras Proteins; Sesquiterpenes; Signal Transduction | 2018 |
Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice.
Topics: Actins; Animals; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Diet; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation; Growth Differentiation Factor 15; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Osteopontin; Primary Cell Culture; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Transcription Factor CHOP; Transforming Growth Factor beta1 | 2018 |
Use of an animal model to test whether non-alcoholic fatty liver disease increases the risk of idiosyncratic drug-induced liver injury.
Topics: Amodiaquine; Animals; Antibodies, Blocking; Chemical and Drug Induced Liver Injury; Choline Deficiency; Disease Models, Animal; Female; Granzymes; Humans; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Programmed Cell Death 1 Receptor; Risk | 2018 |
Selenate sensitivity of a laeA mutant is restored by overexpression of the bZIP protein MetR in Aspergillus fumigatus.
Topics: Alleles; Animals; Aspergillosis; Aspergillus fumigatus; Basic-Leucine Zipper Transcription Factors; Disease Models, Animal; DNA-Binding Proteins; Fungal Proteins; Gene Expression Regulation, Fungal; Gliotoxin; Methionine; Secondary Metabolism; Selenic Acid; Sequence Deletion; Transcription Factors; Transcriptome; Zebrafish | 2018 |
Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease Models, Animal; Gene Silencing; Lipotropic Agents; Liver Neoplasms; Methionine; NF-E2-Related Factor 2; Rats; Treatment Outcome | 2018 |
Investigation of nonalcoholic fatty liver disease-induced drug metabolism by comparative global toxicoproteomics.
Topics: Animals; Choline Deficiency; Chromatography, Liquid; Computational Biology; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Interactions; Isoenzymes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proteomics; Risk Assessment; Substrate Specificity; Tandem Mass Spectrometry; Toxicology; Xenobiotics | 2018 |
NNMT activation can contribute to the development of fatty liver disease by modulating the NAD
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Fatty Liver; Lipoproteins, VLDL; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Transgenic; NAD; Niacinamide; Nicotinamide N-Methyltransferase | 2018 |
Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mTOR pathway.
Topics: Adenylate Kinase; Animals; Autophagy; Cell Line; Cholestenones; Choline; Diet; Disease Models, Animal; Humans; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Dysbiosis; Feces; Gastrointestinal Microbiome; Humans; Intestines; Liver Cirrhosis; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; RNA, Ribosomal, 16S | 2018 |
A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; DNA Helicases; Epigenesis, Genetic; Gene Deletion; Hepatocytes; Histone Acetyltransferases; Methionine; Mice; NADPH Oxidases; Non-alcoholic Fatty Liver Disease; Nuclear Proteins; Promoter Regions, Genetic; Reactive Oxygen Species; Salicylates; Transcription Factors | 2019 |
Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone.
Topics: A549 Cells; Amino Acid Substitution; Animals; Chlorocebus aethiops; Cloning, Molecular; Disease Models, Animal; DNA, Complementary; Evolution, Molecular; Genome, Viral; Humans; Methionine; Mice; Promoter Regions, Genetic; Valine; Vero Cells; Viral Nonstructural Proteins; Virus Replication; Zika Virus; Zika Virus Infection | 2018 |
Metabolic Response in Rabbit Urine to Occurrence and Relief of Unilateral Ureteral Obstruction.
Topics: Acetic Acid; Alanine; Analysis of Variance; Animals; Biomarkers; Citric Acid; Creatinine; Disease Models, Animal; Glycine; Hydronephrosis; Kynurenine; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Metabolome; Methionine; Methylhistidines; Phenylacetates; Rabbits; Ureter; Ureteral Obstruction | 2018 |
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism.
Topics: Animals; Bile Acids and Salts; Disease Models, Animal; Humans; Lipid Metabolism; Methionine; Mice; Progeria | 2018 |
Protective effect of isochlorogenic acid B on liver fibrosis in non-alcoholic steatohepatitis of mice.
Topics: Animals; Chlorogenic Acid; Cholesterol; Disease Models, Animal; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; MicroRNAs; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Random Allocation; Triglycerides | 2019 |
Methionine Partially Replaced by Methionyl-Methionine Dipeptide Improves Reproductive Performance over Methionine Alone in Methionine-Deficient Mice.
Topics: Animal Nutritional Physiological Phenomena; Animals; Biomarkers; Deficiency Diseases; Dietary Supplements; Dipeptides; Disease Models, Animal; Female; Fetal Development; Injections, Intraperitoneal; Maternal Nutritional Physiological Phenomena; Membrane Transport Proteins; Methionine; Mice, Inbred ICR; Mice, Nude; Nutritional Status; Placenta; Pregnancy; Pregnancy Complications; Reproduction; Signal Transduction | 2018 |
Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3/6 pathways in a methionine choline deficient diet steatohepatitis mouse model.
Topics: Animals; Antioxidants; Apoptosis; Choline; Diet; Disease Models, Animal; Drugs, Chinese Herbal; Female; Fibrosis; Liver; Male; Methionine; Mice; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Receptors, Cell Surface | 2018 |
Methionine restriction for improving progeria: another autophagy-inducing anti-aging strategy?
Topics: Aging; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Caloric Restriction; Disease Models, Animal; Longevity; Methionine; Mice; Progeria; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2019 |
De novo NAD
Topics: Animals; Caenorhabditis elegans; Carboxy-Lyases; Cell Line; Choline; Conserved Sequence; Disease Models, Animal; Evolution, Molecular; Female; Gene Knockdown Techniques; Health; Hepatocytes; Homeostasis; Humans; Kidney; Liver; Longevity; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Non-alcoholic Fatty Liver Disease; Rats; Sirtuins | 2018 |
Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Cytokines; Diet, High-Fat; Disease Models, Animal; Inflammation; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Receptors, Nicotinic | 2019 |
Neuroendocrine aging precedes perimenopause and is regulated by DNA methylation.
Topics: Aging; Animals; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Enzyme Inhibitors; Epigenomics; Female; Genome-Wide Association Study; Hypothalamus; Menopause; Methionine; Neurosecretory Systems; Perimenopause; Rats, Sprague-Dawley; Reproduction; Signal Transduction; Transcription, Genetic | 2019 |
Dietary Methionine Restriction Upregulates Endogenous H
Topics: Animals; Body Composition; Body Weight; Cystathionine gamma-Lyase; Diet, High-Fat; Disease Models, Animal; Endoplasmic Reticulum Stress; Hydrogen Sulfide; Liver; Male; Methionine; Mice, Inbred C57BL; MicroRNAs; Obesity; Oxidative Stress; Proteins | 2019 |
MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance.
Topics: Adult; Aged; Animals; Biopsy; Carcinogenesis; Cell Proliferation; Chromatography, Liquid; Colorectal Neoplasms; Disease Models, Animal; Female; Gene Knockdown Techniques; Gene Knockout Techniques; HCT116 Cells; Heterografts; Humans; Immunohistochemistry; Male; Methionine; Mice; Mice, Nude; Microfilament Proteins; Middle Aged; Neoplasm Transplantation; Oxidation-Reduction; Oxidoreductases; Protein Binding; Protein Processing, Post-Translational; Proteolysis; Spectrometry, Mass, Electrospray Ionization; Tumor Suppressor Protein p53; Ubiquitination | 2018 |
Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Microbiome; Genetic Variation; Humans; Inflammation; Liver Cirrhosis; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2019 |
Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction.
Topics: Animals; Annexin A5; Anoikis; Breast Neoplasms; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Female; Fluorescence; Humans; Methionine; Mice; Receptors, TNF-Related Apoptosis-Inducing Ligand | 2019 |
Inhibitory Effects of Sodium Alginate on Hepatic Steatosis in Mice Induced by a Methionine- and Choline-deficient Diet.
Topics: Alginates; Animals; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Fatty Liver; Intestine, Small; Male; Methionine; Mice; Mice, Inbred C57BL; RNA, Messenger; Tumor Necrosis Factor-alpha | 2019 |
Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Folate Receptor 2; Folic Acid; Humans; Liver; Macrophages; Male; Methionine; Mice, Inbred C57BL; Molecular Imaging; Non-alcoholic Fatty Liver Disease; Organotechnetium Compounds; Predictive Value of Tests; Radiopharmaceuticals; Rats, Sprague-Dawley; Tomography, Emission-Computed, Single-Photon | 2019 |
Metabolic characterization of two different non-alcoholic fatty liver disease pre-clinical mouse models.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cholesterol; Choline; Diet, High-Fat; Disease Models, Animal; Fructose; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Random Allocation; Sweetening Agents | 2019 |
Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis.
Topics: AMP-Activated Protein Kinases; Animals; Atherosclerosis; Disease Models, Animal; DNA Methylation; Gene Deletion; Gene Expression; Gene Expression Profiling; Macrophages; Methionine; Mice; Mice, Knockout; Monocytes; Myeloid Cells; Organ Specificity; Plaque, Atherosclerotic | 2019 |
Excessive Methionine Supplementation Exacerbates the Development of Abdominal Aortic Aneurysm in Rats.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Dilatation, Pathologic; Disease Models, Animal; Disease Progression; Glycine N-Methyltransferase; Interleukin-6; Male; Matrix Metalloproteinase 2; Methionine; Osteopontin; Pancreatic Elastase; Rats, Sprague-Dawley; Risk Factors; Time Factors | 2019 |
Circulating Plasma Metabolomic Profiles Differentiate Rodent Models of Pulmonary Hypertension and Idiopathic Pulmonary Arterial Hypertension Patients.
Topics: Adult; Animals; Biomarkers; Case-Control Studies; Disease Models, Animal; Familial Primary Pulmonary Hypertension; Female; Humans; Hypertension, Pulmonary; Hypoxia; Male; Metabolomics; Methionine; Monocrotaline; Rats, Sprague-Dawley; Urea | 2019 |
Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Diet; Disease Models, Animal; Female; Fluorouracil; Genes, p53; Genes, ras; Healthy Volunteers; Humans; Male; Metabolomics; Methionine; Mice; Middle Aged; Mutation; Proof of Concept Study; Sarcoma; Soft Tissue Neoplasms; Sulfur; Treatment Outcome | 2019 |
The beneficial effects of Nardostachys jatamansi extract on diet-induced severe acute pancreatitis.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Female; Methionine; Mice; Mice, Inbred C57BL; Multiple Organ Failure; Nardostachys; Pancreas; Pancreatitis; Plant Extracts; Plants, Medicinal; Time Factors | 2013 |
Quercetin reduces serum homocysteine level in rats fed a methionine-enriched diet.
Topics: Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Glutathione; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Organ Size; Oxidative Stress; Protein Carbonylation; Quercetin; Random Allocation; Rats; Rats, Wistar; Weight Gain | 2013 |
Pharmacological modulation of geranylgeranyltransferase and farnesyltransferase attenuates opioid withdrawal in vivo and in vitro.
Topics: Alkyl and Aryl Transferases; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Farnesyltranstransferase; Female; Ileum; Imidazoles; In Vitro Techniques; Leucine; Male; Methionine; Mice; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Naphthalenes; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2013 |
Leishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages.
Topics: Amino Acid Sequence; Animals; Catalytic Domain; Cell Survival; Chromatography, Liquid; Cytoplasm; Disease Models, Animal; Gene Deletion; Genes, Protozoan; Green Fluorescent Proteins; Hydrogen Peroxide; Leishmania major; Leishmaniasis, Cutaneous; Macrophages; Mass Spectrometry; Methionine; Methionine Sulfoxide Reductases; Mice; Molecular Sequence Data; Oxidative Stress; Parasites; Protein Transport; Sequence Alignment; Subcellular Fractions | 2013 |
Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.
Topics: Animals; Antibodies, Antinuclear; Betaine; CD40 Ligand; Choline; Coenzymes; Diet; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Folic Acid; Gene Silencing; Genetic Predisposition to Disease; Lupus Erythematosus, Systemic; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Micronutrients; Riboflavin; Vitamin B 12; Vitamin B 6; Zinc | 2013 |
Methionine-induced hyperhomocysteinemia impairs the antioxidant ability of high-density lipoproteins without reducing in vivo macrophage-specific reverse cholesterol transport.
Topics: Animals; Antioxidants; Apolipoprotein A-I; Aryldialkylphosphatase; Atherosclerosis; Biological Transport; Cell Line; Cholesterol, HDL; Disease Models, Animal; Female; Homocysteine; Hyperhomocysteinemia; Lipid Metabolism; Liver; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2013 |
Persistent overexpression of DNA methyltransferase 1 attenuating GABAergic inhibition in basolateral amygdala accounts for anxiety in rat offspring exposed perinatally to low-dose bisphenol A.
Topics: Air Pollutants, Occupational; Amygdala; Animals; Anxiety; Benzhydryl Compounds; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Evoked Potentials; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Enzymologic; Glutamate Decarboxylase; In Vitro Techniques; Indolizines; Male; Methionine; Neural Inhibition; Neurons; Phenols; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2013 |
Methionine pretreatment enhances the effects of valproate on axial development in a CD1 mouse model.
Topics: Acetylation; Animals; Blotting, Western; Disease Models, Animal; Embryonic Development; Female; Fetus; Histones; Methionine; Mice; Pregnancy; Valproic Acid | 2013 |
Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Endotoxemia; Fatty Liver; Female; Lipase; Lipopolysaccharides; Liver; Male; Methionine; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; PPAR alpha; Signal Transduction | 2014 |
[The impact of dietary methionine-restriction on tight junction expression and function in a rat colonitis model].
Topics: Animals; Colitis; Diet, Protein-Restricted; Disease Models, Animal; Male; Methionine; Rats; Rats, Sprague-Dawley; Tight Junctions | 2013 |
Methionine down-regulates TLR4/MyD88/NF-κB signalling in osteoclast precursors to reduce bone loss during osteoporosis.
Topics: Acid Phosphatase; Administration, Oral; Alendronate; Animals; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Cells, Cultured; Chemokine CCL3; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Therapy, Combination; Female; Inflammation Mediators; Isoenzymes; Methionine; Myeloid Differentiation Factor 88; NF-kappa B; Osteoclasts; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Tartrate-Resistant Acid Phosphatase; Time Factors; Toll-Like Receptor 4 | 2014 |
Surfactant protein D (SP-D) deficiency is attenuated in humanised mice expressing the Met(11)Thr short nucleotide polymorphism of SP-D: implications for surfactant metabolism in the lung.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Lung; Lung Diseases; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Polymorphism, Single Nucleotide; Pulmonary Surfactant-Associated Protein D; Threonine | 2013 |
Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.
Topics: Animals; Bifidobacterium; Choline Deficiency; Disease Models, Animal; Fatty Liver; Gastrointestinal Tract; Gene Expression Profiling; Inflammation; Lacticaseibacillus casei; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Microbiota; Non-alcoholic Fatty Liver Disease | 2013 |
Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats.
Topics: Animals; Choline Deficiency; Cytochrome P-450 CYP2E1; Disease Models, Animal; Disease Progression; Fatty Liver; Heme Oxygenase-1; Hydrogen Sulfide; Inflammation; Interleukin-6; Liver; Male; Methionine; Mitochondria, Liver; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2014 |
Dynamics of oxidative/nitrosative stress in mice with methionine-choline-deficient diet-induced nonalcoholic fatty liver disease.
Topics: Animals; Antioxidants; C-Reactive Protein; Catalase; Choline Deficiency; Disease Models, Animal; Ferritins; Glutathione; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Mice, Inbred C57BL; Nitrates; Nitrites; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Superoxide Dismutase; Time Factors | 2014 |
Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence.
Topics: Animals; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Disease Models, Animal; Female; Hydrogen Peroxide; Macrophages; Methionine; Mice; Molecular Sequence Data; Oxidative Stress; Phagocytosis; Pneumonia; Protein Structure, Tertiary; Recombinant Proteins; Streptococcus pneumoniae; Survival Analysis; Virulence | 2013 |
IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet.
Topics: Animals; Cell Line; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Hepatic Stellate Cells; Inflammation; Interferon-gamma; Kupffer Cells; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2013 |
D-methionine pre-loading reduces both noise-induced permanent threshold shift and outer hair cell loss in the chinchilla.
Topics: Animals; Auditory Threshold; Chinchilla; Cytoprotection; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Male; Methionine; Time Factors | 2013 |
Cystathionine β-synthase-deficient mice thrive on a low-methionine diet.
Topics: Absorptiometry, Photon; Animals; Cystathionine beta-Synthase; Disease Models, Animal; Female; Homocystinuria; Male; Methionine; Mice; Mice, Knockout | 2014 |
Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Disease Models, Animal; Early Diagnosis; Genetic Markers; Male; Methionine; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; Severity of Illness Index; Time Factors | 2014 |
Development of an animal model for gestational hypermethioninemia in rat and its effect on brain Na⁺,K⁺-ATPase/Mg²⁺-ATPase activity and oxidative status of the offspring.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Animals, Newborn; Brain; Brain Chemistry; Ca(2+) Mg(2+)-ATPase; Catalase; Disease Models, Animal; Female; Glycine N-Methyltransferase; Homocysteine; Maternal-Fetal Exchange; Methionine; Nerve Tissue Proteins; Oxidation-Reduction; Oxidative Stress; Pregnancy; Pregnancy Complications; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2014 |
Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice.
Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aspartate Aminotransferases; Biomarkers; Cell Proliferation; Chemokine CCL2; Choline Deficiency; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Kupffer Cells; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proliferating Cell Nuclear Antigen; RNA, Messenger; Time Factors | 2013 |
Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models.
Topics: Animals; Choline Deficiency; Diabetes Mellitus, Experimental; Diet, Atherogenic; Disease Models, Animal; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Obesity; Organic Anion Transporters; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2014 |
Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of nonalcoholic fatty liver disease.
Topics: Animals; Choline; Diet; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes; Lipids; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Risk Factors; Time Factors | 2014 |
Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH).
Topics: Adipogenesis; Adipose Tissue; Animals; Choline; Disease Models, Animal; Fatty Acids; Fatty Acids, Nonesterified; Fatty Liver; Fibroblast Growth Factors; Inflammation; Lipase; Lipid Metabolism; Lipolysis; Liver; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Oxidation-Reduction | 2014 |
n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-6; Inflammation Mediators; Liver; Liver Cirrhosis; Male; Methionine; Mice, Inbred BALB C; Necrosis; Non-alcoholic Fatty Liver Disease; Olive Oil; Plant Oils; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2014 |
Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice.
Topics: Animals; Annexin A1; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Hepatitis; Humans; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Obesity | 2014 |
Striatal synaptosomes from Hdh140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation.
Topics: Animals; Blotting, Western; Chromatography, Liquid; Corpus Striatum; Disease Models, Animal; Gene Knock-In Techniques; Glutamic Acid; Huntingtin Protein; Huntington Disease; Methionine; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nuclear Proteins; Oxidation-Reduction; Synaptosomes; Tandem Mass Spectrometry | 2013 |
Effect of Trifolium pratense extract on methionine-choline-deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Animals; Cholesterol; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phytotherapy; Plant Extracts; PPAR gamma; RNA, Messenger; Trifolium; Triglycerides | 2014 |
Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma.
Topics: Acetyltransferases; Animals; Carcinoma, Hepatocellular; Choline; Diet; Diethylnitrosamine; Disease Models, Animal; Fatty Acid Elongases; Fatty Acids; Humans; Inflammation; Liver Neoplasms; Methionine; Mice; Mice, Inbred DBA; Mice, Obese; Non-alcoholic Fatty Liver Disease; RNA, Messenger | 2014 |
Bile acids override steatosis in farnesoid X receptor deficient mice in a model of non-alcoholic steatohepatitis.
Topics: Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear | 2014 |
Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.
Topics: Amino Acids, Neutral; Animals; Comorbidity; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Female; Homocystinuria; Hyperhomocysteinemia; Kidney Tubules, Proximal; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Renal Aminoacidurias | 2014 |
Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.
Topics: Acetylcholinesterase; Animals; Apoptosis; Betaine; Cerebellum; Choline; Choline O-Acetyltransferase; Disease Models, Animal; DNA Methylation; Ferredoxin-NADP Reductase; Gene Expression; Hippocampus; Homocysteine; Homocystinuria; Hyperhomocysteinemia; Male; Memory, Short-Term; Methionine; Mice; Mice, Knockout; Synaptic Transmission | 2014 |
The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model.
Topics: Amyloid Neuropathies, Familial; Animals; Disease Models, Animal; Female; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Humans; Inflammation; Locomotion; Male; Methionine; Mice; Mice, Transgenic; Mutation; Pain Measurement; Prealbumin; Schwann Cells; Sciatic Neuropathy; Time Factors; Valine | 2014 |
Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease.
Topics: Animals; Body Weight; Copper; Disease Models, Animal; DNA Methylation; Gene Expression Regulation; Hepatolenticular Degeneration; Lipid Metabolism; Liver; Methionine; Mice | 2014 |
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.
Topics: Amitriptyline; Animals; Autophagy; Ceramides; Cholesterol; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Endoplasmic Reticulum Stress; Humans; Liver; Lysosomes; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Permeability; Sphingomyelin Phosphodiesterase; Sphingomyelins | 2014 |
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Acids; Fibroblast Growth Factors; Hepatitis; Inflammation Mediators; Infusions, Subcutaneous; Lipid Peroxidation; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Recombinant Proteins; RNA, Messenger; Severity of Illness Index; Time Factors | 2014 |
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.
Topics: Amino Acid Substitution; Animals; Chromatin; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Gene Silencing; Glioma; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methionine; Methylation; Mutation; Signal Transduction | 2014 |
Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency.
Topics: Animals; Brain; Catalase; Cerebral Cortex; Choline Deficiency; Corpus Striatum; Disease Models, Animal; Glutathione; Hippocampus; Hypothalamus; Lipid Peroxidation; Male; Malondialdehyde; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide; Oxidative Stress; Superoxide Dismutase; Thioctic Acid | 2015 |
Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia.
Topics: Animals; Cerebral Arteries; Diet; Disease Models, Animal; Endothelium, Vascular; Female; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Knockout; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Phenotype; Reactive Oxygen Species; Thrombosis; Vasodilator Agents | 2014 |
Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice.
Topics: Adenocarcinoma in Situ; Animals; Body Composition; Body Weight; Cell Proliferation; Diet; Disease Models, Animal; Insulin-Like Growth Factor I; Male; Methionine; Mice; Mice, Mutant Strains; Mice, Transgenic; Prostate; Prostatic Neoplasms | 2014 |
Methionine restriction slows down senescence in human diploid fibroblasts.
Topics: Age Factors; Animals; Diploidy; Disease Models, Animal; Fibroblasts; Humans; Methionine; Mitochondria; Oxidative Stress | 2014 |
Hyperhomocysteinemia is a result, rather than a cause, of depression under chronic stress.
Topics: Animals; Behavior, Animal; Betaine-Homocysteine S-Methyltransferase; Chronic Disease; Depression; Disease Models, Animal; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats, Wistar; Recombinant Proteins; Sertraline; Stress, Psychological | 2014 |
Disturbed flow induces systemic changes in metabolites in mouse plasma: a metabolomics study using ApoE⁻/⁻ mice with partial carotid ligation.
Topics: Animals; Apolipoproteins E; Biomarkers; Carotid Arteries; Carotid Artery Diseases; Carotid Stenosis; Chromatography, Liquid; Disease Models, Animal; Ligation; Male; Mass Spectrometry; Metabolomics; Methionine; Mice, Knockout; Phenylalanine; Phosphatidylcholines; Phosphatidylethanolamines; Regional Blood Flow; Sphingomyelins; Time Factors | 2015 |
Homocysteine-induced attenuation of vascular endothelium-dependent hyperalgesia in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Cardiovascular Agents; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Homocysteine; Hyperalgesia; Hypoxia-Ischemia, Brain; Male; Methionine; Movement; Muscle, Skeletal; Myalgia; Rats, Sprague-Dawley; Reflex Sympathetic Dystrophy; Touch; Vibration | 2015 |
[Catecholamine content in the adrenal gland of rat offspring in the model of prenatal hyperhomocysteinemia].
Topics: Administration, Oral; Adrenal Glands; Animals; Animals, Newborn; Catecholamines; Disease Models, Animal; Female; Hyperhomocysteinemia; Methionine; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Tyrosine | 2014 |
Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis.
Topics: Animals; Cholesterol; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Acids; Female; Inflammation Mediators; Iron; Lipid Peroxidation; Liver; Male; Methionine; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; RNA-Binding Proteins; Time Factors; Up-Regulation | 2014 |
Transmission properties of atypical Creutzfeldt-Jakob disease: a clue to disease etiology?
Topics: Aged; Animals; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Female; Homozygote; Humans; Iatrogenic Disease; Male; Methionine; Mice; Middle Aged; Mutant Proteins; Mutation, Missense; Neurosurgical Procedures; Occupational Exposure; Prion Proteins; Prions; Surgeons | 2015 |
6-gingerol protects against nutritional steatohepatitis by regulating key genes related to inflammation and lipid metabolism.
Topics: Animals; Catechols; Chemokine CCL2; Choline Deficiency; Disease Models, Animal; Fatty Alcohols; Fatty Liver; Inflammation; Interleukin-6; Lipid Metabolism; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Plant Extracts; Tumor Necrosis Factor-alpha | 2015 |
MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Cluster Analysis; Diet; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Liver Cirrhosis; Male; Metformin; Methionine; Mice; MicroRNAs; Non-alcoholic Fatty Liver Disease; Transcriptome | 2015 |
Nebivolol to attenuate the effects of hyper-homocysteinaemia in rats.
Topics: Animals; Antioxidants; Aorta, Thoracic; Biomarkers; Brain; Catalase; Cytoprotection; Disease Models, Animal; Glutathione; Hyperhomocysteinemia; Kidney; Liver; Male; Malondialdehyde; Methionine; Myocardium; Nebivolol; Oxidative Stress; Rats, Wistar; Superoxide Dismutase; Time Factors; Vascular Remodeling | 2015 |
Dysfunction of blood pressure regulation in hyperhomocyteinemia model in rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cardiovascular Diseases; Disease Models, Animal; Elastic Tissue; Epinephrine; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Oxidation-Reduction; Rats, Sprague-Dawley; Risk Factors; Thiobarbiturates | 2015 |
Plasma asymmetric and symmetric dimethylarginine in a rat model of endothelial dysfunction induced by acute hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Cathepsin D; Disease Models, Animal; Endothelium, Vascular; Gene Expression Regulation; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; Ubiquitin | 2015 |
Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis.
Topics: Animals; Biomarkers; Blotting, Western; Choline Deficiency; Diet; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Immunoenzyme Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
Sporadic Creutzfeldt-Jakob Disease MM1+2C and MM1 are Identical in Transmission Properties.
Topics: Aged; Animals; Brain; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Female; Genotype; Humans; Male; Methionine; Mice; Mutant Proteins; Prion Proteins; Prions | 2016 |
Dietary Supplementation of Genistein Alleviates Liver Inflammation and Fibrosis Mediated by a Methionine-Choline-Deficient Diet in db/db Mice.
Topics: Animals; Choline; Diet; Dietary Supplements; Disease Models, Animal; Genistein; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Oxidative Stress | 2015 |
MRI versus histological methods for time course monitoring of steatosis amount in a murine model of NAFLD.
Topics: Adipose Tissue; Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Humans; Image Interpretation, Computer-Assisted; Liver; Magnetic Resonance Imaging; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; Statistics as Topic; Triglycerides | 2015 |
Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Catechin; Choline Deficiency; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Inflammation Mediators; Lipids; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Signal Transduction; Transforming Growth Factor beta | 2015 |
A Methionine-Induced Animal Model of Schizophrenia: Face and Predictive Validity.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Depression; Disease Models, Animal; Haloperidol; Male; Methionine; Mice; Motor Activity; Pain Threshold; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Sensory Gating; Social Behavior; Stereotyped Behavior; Treatment Outcome | 2015 |
Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.
Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Triglycerides | 2015 |
MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Nucleus; Choline; Diet; Disease Models, Animal; Fatty Liver; Female; Gene Expression Regulation; Inflammation; Lipid Metabolism; Lipopolysaccharides; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; MicroRNAs; Protein Binding; Smad3 Protein; Tumor Necrosis Factor-alpha; Vimentin | 2015 |
Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Diet; Dietary Carbohydrates; Disease Models, Animal; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Inbred C3H; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitates; Sucrose | 2015 |
Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease.
Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Triglycerides | 2015 |
Protective effect of ursodeoxycholic acid, resveratrol, and N-acetylcysteine on nonalcoholic fatty liver disease in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Choline Deficiency; Cytoprotection; Disease Models, Animal; Hypolipidemic Agents; Lipids; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats, Wistar; Resveratrol; Stilbenes; Ursodeoxycholic Acid | 2016 |
Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance.
Topics: Administration, Oral; Animals; Biomarkers; Blood Glucose; Chemical and Drug Induced Liver Injury; Choline Deficiency; Concanavalin A; Cytoprotection; Diet, High-Fat; Disease Models, Animal; Glycine max; Immunologic Factors; Insulin; Insulin Resistance; Lipids; Liver; Metabolic Syndrome; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Plant Extracts; T-Lymphocytes, Regulatory; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.
Topics: Animals; Case-Control Studies; Cell Death; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Hepatocytes; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Palmitic Acid; Rats; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2015 |
The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation.
Topics: Alcohol Drinking; Alcoholism; Alleles; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Compulsive Behavior; Disease Models, Animal; Methionine; Mice; Mice, Transgenic; Polymorphism, Single Nucleotide; Protein-Tyrosine Kinases; Receptor, trkB; Valine | 2016 |
Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice.
Topics: Animals; Betaine; Bone Density; Cystathionine beta-Synthase; Diet; Dietary Supplements; Disease Models, Animal; Female; Homocystinuria; Male; Methionine; Mice; Mice, Inbred C57BL; Osteoporosis; Phenotype; Weight Gain; Weight Loss | 2016 |
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
Topics: Animals; Autophagy; Cell Culture Techniques; Disease Models, Animal; Fatty Liver; Hepatocytes; Humans; Methionine; Methylation; Mice; Protein Phosphatase 2; S-Adenosylmethionine | 2016 |
Evaluation of Nonalcoholic Fatty Liver Disease in C57BL/6J Mice by Using MRI and Histopathologic Analyses.
Topics: Animals; Area Under Curve; Biopsy; Choline Deficiency; Disease Models, Animal; Liver; Magnetic Resonance Imaging; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; Reproducibility of Results; ROC Curve; Severity of Illness Index | 2015 |
The Ethanol Extract from Lonicera japonica Thunb. Regresses Nonalcoholic Steatohepatitis in a Methionine- and Choline-Deficient Diet-Fed Animal Model.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Liver; Liver Cirrhosis; Lonicera; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phytotherapy; Plant Extracts; Signal Transduction | 2015 |
Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse.
Topics: Animals; Antidepressive Agents; Brain; Cell Proliferation; Cell Survival; Citalopram; Depression; Disease Models, Animal; Fluoxetine; Food Preferences; Gene Expression Regulation; Hindlimb Suspension; Hippocampus; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes | 2016 |
Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation.
Topics: Animals; Apoptosis; Benzophenanthridines; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Gene Expression; Humans; Isoquinolines; Lung Neoplasms; Membrane Glycoproteins; Membrane Proteins; Methionine; Mice; Models, Biological; Models, Molecular; Molecular Conformation; NADPH Oxidase 2; NADPH Oxidases; Oxidation-Reduction; Protein Binding; Protein Kinase Inhibitors; Proteolysis; Quinazolines; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2016 |
High Methionine Diet Poses Cardiac Threat: A Molecular Insight.
Topics: Animals; Cardiovascular System; Diet; Disease Models, Animal; Gene Expression Regulation; Heart; Humans; Inflammation; Methionine; Mice; Oxidative Stress; Protein Biosynthesis; Red Meat; Ventricular Remodeling | 2016 |
Sulfur amino acids and atherosclerosis: a role for excess dietary methionine.
Topics: Amino Acids, Sulfur; Animals; Apolipoproteins E; Atherosclerosis; Biomarkers; Blood Chemical Analysis; Diet; Disease Models, Animal; Homocysteine; Metabolic Networks and Pathways; Methionine; Mice; Mice, Knockout; Plaque, Atherosclerotic; Time Factors | 2016 |
Effects of Dietary Copper-Methionine on Matrix Metalloproteinase-2 in the Lungs of Cold-Stressed Broilers as an Animal Model for Pulmonary Hypertension.
Topics: Animals; Chickens; Copper; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension, Pulmonary; Lung; Matrix Metalloproteinase 2; Methionine; RNA, Messenger | 2016 |
Methionine sulfoxide reductase A affects β-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Respiration; Disease Models, Animal; Electron Transport Complex IV; Gene Knock-In Techniques; Methionine; Methionine Sulfoxide Reductases; Mice; Mice, Knockout; Mitochondria; Solubility | 2016 |
Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.
Topics: Animals; Biomarkers; Choline Deficiency; Colon; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Gene Expression Regulation; Hormones, Ectopic; Intercellular Signaling Peptides and Proteins; Kupffer Cells; Liver; Macrophages; Male; Methionine; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Toll-Like Receptor 4; Transcription, Genetic | 2016 |
Relationship between liver tissue stiffness and histopathological findings analyzed by shear wave elastography and compression testing in rats with non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Elastic Modulus; Elasticity Imaging Techniques; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats, Wistar; Severity of Illness Index | 2016 |
Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis.
Topics: Animals; Choline; Diet; Disease Models, Animal; Hepatitis; Interleukin-17; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Receptors, Interleukin-17; Signal Transduction; T-Lymphocytes | 2016 |
Selenium Inhibits Homocysteine-Induced Endothelial Dysfunction and Apoptosis via Activation of AKT.
Topics: Animals; Apoptosis; Cell Movement; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Gene Expression Regulation; Homocysteine; Human Umbilical Vein Endothelial Cells; Humans; Male; Methionine; Proto-Oncogene Proteins c-akt; Rats; Selenium | 2016 |
Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells.
Topics: Actins; Animals; Blotting, Western; Cells, Cultured; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fluorescent Antibody Technique; Hepatic Stellate Cells; Immunoenzyme Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sirtuin 3; Succinate Dehydrogenase | 2016 |
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Case-Control Studies; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Choline; Diet; Disease Models, Animal; Genes, myc; Hepatocytes; Humans; Linoleic Acid; Lipid Metabolism; Liver; Liver Neoplasms; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Reactive Oxygen Species | 2016 |
Ischemia-Reperfusion Injury in Fatty Liver Is Mediated by Activated NADPH Oxidase 2 in Rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cells, Cultured; Choline Deficiency; Deoxyguanosine; Disease Models, Animal; Enzyme Inhibitors; Fatty Liver; HMGB1 Protein; Inflammation Mediators; Interleukin-6; Liver; Macrophages; Male; Membrane Glycoproteins; Methionine; NADPH Oxidase 2; NADPH Oxidases; Necrosis; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Time Factors; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2016 |
BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice.
Topics: Animals; Anorexia Nervosa; Behavior, Animal; Brain-Derived Neurotrophic Factor; Caloric Restriction; Disease Models, Animal; Feeding Behavior; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Methionine; Mice; Polymorphism, Single Nucleotide; Risk Factors; Severity of Illness Index; Stress, Psychological; Valine | 2016 |
(1)H NMR-Based Analysis of Serum Metabolites in Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats.
Topics: Animals; Arterial Pressure; Disease Models, Animal; Disease Progression; Energy Metabolism; Glycolysis; Hypertension, Pulmonary; Lipid Metabolism; Male; Metabolome; Methionine; Monocrotaline; Proton Magnetic Resonance Spectroscopy; Pulmonary Artery; Rats; Rats, Sprague-Dawley | 2016 |
Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biotinylation; Brain; Cerebral Amyloid Angiopathy; Dementia, Vascular; Disease Models, Animal; Disease Progression; Fibrin; Fibrinogen; Fibrinolysis; Humans; Hyperhomocysteinemia; Immunohistochemistry; Maze Learning; Memory; Methionine; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Binding | 2016 |
Alterations in glutamate cysteine ligase content in the retina of two retinitis pigmentosa animal models.
Topics: Animals; Cysteine; Disease Models, Animal; Glutamate-Cysteine Ligase; Glutathione Disulfide; Humans; Methionine; Mice; Oxidative Stress; Retina; Retinal Degeneration; Retinitis Pigmentosa; Sulfoxides | 2016 |
Mainstream cigarette smoke accelerates the progression of nonalcoholic steatohepatitis by modulating Kupffer cell-mediated hepatocellular apoptosis in adolescent mice.
Topics: Age Factors; Animals; Apoptosis; Cells, Cultured; Choline Deficiency; Cytokines; Disease Models, Animal; Disease Progression; Hepatocytes; Inflammation Mediators; Kupffer Cells; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Paracrine Communication; Severity of Illness Index; Signal Transduction; Smoke; Smoking; Time Factors | 2016 |
BDNF Val66Met Genotype Interacts With a History of Simulated Stress Exposure to Regulate Sensorimotor Gating and Startle Reactivity.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; Female; Male; Methionine; Mice, Inbred C57BL; Prepulse Inhibition; Psychotic Disorders; Reflex, Startle; Schizophrenia; Sensory Gating; Steroids; Stress, Psychological; Valine | 2017 |
S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway.
Topics: Animals; Antioxidants; Biomarkers; Choline Deficiency; Cysteine; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Hep G2 Cells; Humans; Lipid Peroxidation; Liver; Male; Membrane Proteins; Methionine; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Transfection | 2016 |
Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet.
Topics: Animals; Bupropion; Choline; Choline Deficiency; Cytochrome P-450 CYP2B1; Diet, High-Fat; Disease Models, Animal; Humans; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2016 |
Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice.
Topics: Animals; Apoptosis; Cells, Cultured; Choline Deficiency; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Gene Expression; Hepatic Stellate Cells; Hepatocytes; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Recombinant Proteins | 2016 |
Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis.
Topics: Animals; CD11b Antigen; Cell Count; Choline; Concanavalin A; Disease Models, Animal; Hepatitis, Autoimmune; Kupffer Cells; Lectins, C-Type; Liver; Male; Methionine; Mice, Inbred C57BL; Molecular Imaging; Prognosis; Single-Domain Antibodies; Tissue Distribution | 2017 |
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats.
Topics: Aneurysm, Ruptured; Animals; Arteries; Blood Pressure; Cysteine; Cytokines; Disease Models, Animal; Female; Folic Acid; Hyperhomocysteinemia; Matrix Metalloproteinase 9; Methionine; NADPH Oxidase 4; NADPH Oxidases; Ovariectomy; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Vitamin B Complex | 2016 |
MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Choline; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Male; Methionine; Rats; Rats, Wistar | 2016 |
Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice.
Topics: Animals; Body Weight; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Fibronectins; Gene Expression Regulation; Genotype; Hippocampus; Humans; Male; Mental Disorders; Methionine; Mice; Mice, Transgenic; Neurogenesis; Neuronal Plasticity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Physical Conditioning, Animal; Polymorphism, Single Nucleotide; Swimming; Valine | 2016 |
Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity.
Topics: Analysis of Variance; Animals; Benzophenones; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Choice Behavior; Cognition Disorders; Disease Models, Animal; Exploratory Behavior; Genotype; Maze Learning; Methionine; Mice; Mice, Transgenic; Nitrophenols; Polymorphism, Single Nucleotide; Reaction Time; Tolcapone; Valine | 2016 |
11C-Methionine PET of Myocardial Inflammation in a Rat Model of Experimental Autoimmune Myocarditis.
Topics: Animals; Autoimmune Diseases; Biological Transport; Carbon Radioisotopes; Disease Models, Animal; Female; Methionine; Myocarditis; Positron-Emission Tomography; Rats | 2016 |
Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cells, Cultured; Choline Deficiency; Diet; Disease Models, Animal; Female; Fibroblast Growth Factors; Humans; Lipolysis; Liver; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Ovary; Sex Factors; Testis; Uncoupling Protein 1; Up-Regulation | 2016 |
DNA methylation regulates gabrb2 mRNA expression: developmental variations and disruptions in l-methionine-induced zebrafish with schizophrenia-like symptoms.
Topics: Animals; Disease Models, Animal; DNA Methylation; gamma-Aminobutyric Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Methionine; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptors, GABA; RNA, Messenger; Schizophrenia; Zebrafish | 2016 |
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Topics: Animals; Antibodies, Neutralizing; Autoimmune Diseases; Autoimmunity; B-Lymphocytes; Cytokines; Deubiquitinating Enzymes; Disease Models, Animal; Endopeptidases; Germ-Line Mutation; Humans; Inflammation; Infliximab; Methionine; Mice; Mice, Mutant Strains; Myeloid Cells; Polyubiquitin; Sequence Deletion; Syndrome; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2016 |
Neuroprotective Effects of Simvastatin and Cilostazol in L-Methionine-Induced Vascular Dementia in Rats.
Topics: Animals; Brain; Cilostazol; Dementia, Vascular; Disease Models, Animal; Endothelium, Vascular; Male; Maze Learning; Memory; Methionine; Neuroprotective Agents; Oxidative Stress; Rats, Wistar; Simvastatin; Tetrazoles | 2017 |
Targeting Amino Acid Metabolism for Molecular Imaging of Inflammation Early After Myocardial Infarction.
Topics: Animals; Carbon Isotopes; Disease Models, Animal; Inflammation; Macrophages; Methionine; Mice; Mice, Inbred C57BL; Molecular Imaging; Myocardial Infarction; Positron-Emission Tomography | 2016 |
Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model.
Topics: Animals; Choline; Copper; Dietary Supplements; Disease Models, Animal; DNA Methylation; Epigenomics; Female; Gene Expression Regulation; Hepatolenticular Degeneration; Humans; Liver; Methionine; Mice; Oxidative Phosphorylation; Penicillamine; Pregnancy; Transcriptome | 2016 |
Modeling fatty liver disease in animals: Is there an optimal approach, and is the effort worthwhile?
Topics: Animals; Choline Deficiency; Disease Models, Animal; Humans; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2016 |
New Potential Biomarker Proteins for Alcoholic Liver Disease Identified by a Comparative Proteomics Approach.
Topics: Animals; Biomarkers; Choline Deficiency; Disease Models, Animal; Gene Expression Regulation; Liver Diseases, Alcoholic; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proteomics | 2017 |
l-Methionine and silymarin: A comparison of prophylactic protective capabilities in acetaminophen-induced injuries of the liver, kidney and cerebral cortex.
Topics: Acetaminophen; Animals; Antioxidants; Anxiety; Behavior, Animal; Biomarkers; Brain Diseases; Cerebral Cortex; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Grooming; Kidney; Kidney Diseases; Liver; Memory, Short-Term; Methionine; Motor Activity; Organ Specificity; Oxidative Stress; Rats, Wistar; Silymarin; Spatial Memory; Time Factors; Weight Gain | 2017 |
Altered Gut Microbiota Composition and Immune Response in Experimental Steatohepatitis Mouse Models.
Topics: Alanine Transaminase; Animals; Bacteroidetes; Cholesterol; Choline; Clostridiales; Diet; Diet, High-Fat; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Gastrointestinal Microbiome; Ileum; Interleukin-17; Intestines; Liver; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Portal Vein; Real-Time Polymerase Chain Reaction; Severity of Illness Index; Triglycerides | 2017 |
Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency.
Topics: Animals; Asteraceae; Caffeic Acids; Cell Line; Choline Deficiency; Disease Models, Animal; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Lipid Metabolism; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Plant Extracts; Succinates | 2017 |
Tubulin alpha 8 is expressed in hepatic stellate cells and is induced in transformed hepatocytes.
Topics: Aged; Aged, 80 and over; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Choline; Diet, High-Fat; Disease Models, Animal; Hep G2 Cells; Hepatic Stellate Cells; Humans; Liver Neoplasms; Male; Methionine; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; RAW 264.7 Cells; Tubulin; Up-Regulation | 2017 |
Methionine Sulfoxide Reductase A Deficiency Exacerbates Cisplatin-Induced Nephrotoxicity via Increased Mitochondrial Damage and Renal Cell Death.
Topics: Acute Kidney Injury; Animals; Cell Death; Cell Line; Cisplatin; Disease Models, Animal; Genu Valgum; GTP Phosphohydrolases; Methionine; Methionine Sulfoxide Reductases; Mice; Mitochondria; Mitochondrial Proteins; Oxidative Stress | 2017 |
A compromised liver alters polychlorinated biphenyl-mediated toxicity.
Topics: Adipokines; Animals; Aroclors; Biomarkers; Blood Glucose; Cardiovascular Diseases; Choline; Diet; Disease Models, Animal; Energy Metabolism; Fatty Liver; Gene Expression; Homeostasis; Inflammation; Liver; Liver Cirrhosis; Male; Methionine; Mice, Inbred C57BL; Polychlorinated Biphenyls | 2017 |
Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis.
Topics: Analgesics, Opioid; Animals; Antibodies; Arthritis, Experimental; CD8 Antigens; CD8-Positive T-Lymphocytes; Collagen; Disease Models, Animal; Enkephalins; Female; Freund's Adjuvant; Functional Laterality; Hyperalgesia; Inflammation; Methionine; Mice; Mice, Inbred BALB C; Pain Measurement; Pain Threshold; Time Factors | 2017 |
Involvement of histone methylation in macrophage apoptosis and unstable plaque formation in methionine-induced hyperhomocysteinemic ApoE
Topics: Animals; Apolipoproteins E; Apoptosis; Disease Models, Animal; Histones; Hyperhomocysteinemia; Methionine; Methylation; Mice; Mice, Knockout; Plaque, Atherosclerotic | 2017 |
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Topics: Animals; Cell Adhesion Molecules; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Disease Progression; Integrin beta Chains; Liver; Lymphocyte Subsets; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucoproteins; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2017 |
Influence of hyperglycemia on liver inflammatory conditions in the early phase of non-alcoholic fatty liver disease in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Hyperglycemia; Inflammation; Liver; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2017 |
Suv39h2 deficiency ameliorates diet-induced steatosis in mice.
Topics: Animals; Blotting, Western; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Gene Expression; Histone-Lysine N-Methyltransferase; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Sirtuin 1; Up-Regulation | 2017 |
p16 deficiency promotes nonalcoholic steatohepatitis via regulation of hepatic oxidative stress.
Topics: Animals; Cell Line, Tumor; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; Disease Models, Animal; Food, Formulated; Gene Expression Regulation; Hepatocytes; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred BALB C; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidative Stress; RNA, Small Interfering | 2017 |
MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes.
Topics: Adipocytes; Adipogenesis; Adiponectin; Alanine Transaminase; AMP-Activated Protein Kinase Kinases; Animals; Choline Deficiency; Dietary Fats; Disease Models, Animal; Fatty Acid-Binding Proteins; Fatty Liver; Female; Hepatitis; Hepatocytes; Lipid Peroxides; Methionine; Mice; Mice, Inbred C57BL; PPAR gamma; Protein Kinases; Triglycerides | 2008 |
Effects of hyperhomocysteinemia on non-adrenergic non-cholinergic relaxation in isolated rat duodenum.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Disease Models, Animal; Duodenum; Electric Stimulation; Enteric Nervous System; Enzyme Inhibitors; Epinephrine; gamma-Aminobutyric Acid; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sulfathiazoles | 2008 |
Early effects of copper accumulation on methionine metabolism.
Topics: Adenosine Triphosphatases; Animals; Betaine-Homocysteine S-Methyltransferase; Cation Transport Proteins; Copper; Copper-Transporting ATPases; Disease Models, Animal; Hepatolenticular Degeneration; Humans; Liver; Methionine; Methionine Adenosyltransferase; Models, Biological; Oxidation-Reduction; Protein Folding; Rats; Rats, Inbred LEC; Rats, Long-Evans; RNA, Messenger | 2008 |
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.
Topics: Amidohydrolases; Animals; Arginine; Carotid Arteries; Cell Line; Cystathionine beta-Synthase; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Folic Acid; Gene Expression Regulation, Enzymologic; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; RNA, Messenger; Vasodilation; Vasodilator Agents | 2008 |
Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy.
Topics: Amyloid Neuropathies, Familial; Animals; Apoptosis; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; fas Receptor; Gastrointestinal Tract; Heat-Shock Proteins; Humans; Immunohistochemistry; Methionine; Mice; Mice, Transgenic; Molecular Chaperones; Mutant Proteins; Mutation; Oxidation-Reduction; Prealbumin; Protein Structure, Quaternary; Taurochenodeoxycholic Acid; Thermodynamics; Tyrosine | 2008 |
Effects of nitric oxide modulators on cardiovascular risk factors in mild hyperhomocysteinaemic rat model.
Topics: Acyl Coenzyme A; Animals; Aorta, Thoracic; C-Reactive Protein; Cardiovascular Diseases; Caveolin 2; Disease Models, Animal; Hyperhomocysteinemia; Leukotrienes; Lipid Metabolism; Liver; Male; Methionine; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; Oxidative Stress; Rats; Rats, Wistar; Receptors, Purinergic P2; Resistin; Risk Factors | 2008 |
Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice.
Topics: Animals; Antioxidants; Aorta; Aryldialkylphosphatase; Biomarkers; Caffeic Acids; Cystathionine beta-Synthase; Disease Models, Animal; Female; Flavonoids; Gene Expression Regulation, Enzymologic; Heterozygote; Homocysteine; Hyperhomocysteinemia; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Phenols; Polyphenols; Receptors, Oxidized LDL; Wine | 2009 |
Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Survival; Disease Models, Animal; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Humans; Jurkat Cells; Leukemia; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; RNA Interference; S-Adenosylmethionine | 2008 |
S-adenosylmethionine and proliferation: new pathways, new targets.
Topics: AMP-Activated Protein Kinases; Animals; Antigens, Surface; Cell Proliferation; Disease Models, Animal; ELAV Proteins; ELAV-Like Protein 1; Hepatocytes; Humans; Liver; Liver Diseases; Methionine; Mice; Mice, Knockout; Multienzyme Complexes; Protein Serine-Threonine Kinases; RNA-Binding Proteins; S-Adenosylmethionine; Signal Transduction | 2008 |
Methionine metabolism in an animal model of sepsis.
Topics: Animals; Cysteine; Disease Models, Animal; Glutathione; Homocysteine; Lipopolysaccharides; Male; Methionine; Oxidation-Reduction; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Sepsis | 2008 |
Proteomic changes associated with diabetes in the BB-DP rat.
Topics: Animals; Carnitine; Citrate (si)-Synthase; Diabetes Mellitus, Type 1; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gluconeogenesis; Glycolysis; Liver; Male; Methionine; Muscle, Skeletal; Myocardium; Proteomics; Rats; Rats, Inbred BB; Reactive Oxygen Species | 2009 |
VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice.
Topics: Actins; Animals; Choline Deficiency; Collagen Type I; Diet; Disease Models, Animal; Fatty Liver; Female; Liver Cirrhosis; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Peroxisome Proliferator-Activated Receptors; Probiotics; Signal Transduction; Transforming Growth Factor beta | 2009 |
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase.
Topics: Animals; Apoptosis; Cell Survival; Choline Deficiency; Disease Models, Animal; Fatty Acids; Fatty Liver; Fluorescent Antibody Technique; Hepatocytes; Immunoblotting; Lipids; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Small Interfering; Stearoyl-CoA Desaturase | 2009 |
Utility of a 13C-methacetin breath test in evaluating hepatic injury in rats.
Topics: Acetamides; Administration, Oral; Animals; Breath Tests; Carbon Isotopes; Choline Deficiency; Disease Models, Animal; Fatty Liver; Hepatectomy; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Liver Failure, Acute; Liver Function Tests; Male; Methionine; Organ Size; Predictive Value of Tests; Rats; Rats, Wistar; Severity of Illness Index; Thioacetamide; Time Factors | 2008 |
TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.
Topics: Adenosylhomocysteinase; Animals; Base Sequence; Disease Models, Animal; DNA Primers; Fatty Liver; Humans; Larva; Lipogenesis; Liver Diseases; Male; Methionine; Mitochondria, Liver; Models, Biological; Mutation; Oxidative Stress; Phenotype; Species Specificity; Tubercidin; Tumor Necrosis Factor-alpha; Zebrafish; Zebrafish Proteins | 2009 |
Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression.
Topics: Alanine Transaminase; Animals; Apoptosis; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; fas Receptor; Fatty Liver; Gene Expression Regulation; Insulin-Like Growth Factor I; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nutritional Status; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Messenger; Time Factors; Tumor Suppressor Protein p53 | 2009 |
Experimental hyperhomocysteinaemia: differences in tissue metabolites between homocystine and methionine feeding in a rat model.
Topics: Analysis of Variance; Animal Feed; Animals; Cardiovascular Diseases; Dietary Supplements; Disease Models, Animal; Female; Homocystine; Hyperhomocysteinemia; Kidney; Liver; Methionine; Methylation; Rats; Rats, Wistar; S-Adenosylmethionine; Statistics, Nonparametric; Tissue Distribution | 2009 |
Metabolism of methionine in vivo: impact of pregnancy, protein restriction, and fatty liver disease.
Topics: Animals; Diet, Protein-Restricted; Disease Models, Animal; Fatty Liver; Female; Fetal Growth Retardation; Folic Acid; Humans; Insulin Resistance; Methionine; Models, Animal; Pregnancy | 2009 |
Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue.
Topics: Adipocytes; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blood Pressure; Cell Line; Cell Size; Chemokine CCL2; Choline Deficiency; Collagen Type I; Disease Models, Animal; Disease Progression; Drinking; Eating; Fatty Liver; Intra-Abdominal Fat; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Organ Size; Oxidative Stress; Receptors, CCR2; RNA, Messenger; Telmisartan; Transforming Growth Factor beta1; Triglycerides | 2009 |
High dietary taurine reduces apoptosis and atherosclerosis in the left main coronary artery: association with reduced CCAAT/enhancer binding protein homologous protein and total plasma homocysteine but not lipidemia.
Topics: Analysis of Variance; Animals; Apoptosis; CCAAT-Binding Factor; Coronary Artery Disease; Diet, Atherogenic; Dietary Supplements; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Hyperlipidemias; Male; Methionine; Nitric Oxide; Oxidative Stress; Probability; Rabbits; Random Allocation; Reference Values; Sensitivity and Specificity; Taurine | 2009 |
Deletion of mouse MsrA results in HBO-induced cataract: MsrA repairs mitochondrial cytochrome c.
Topics: Animals; Cataract; Cell Line; Cytochromes c; Disease Models, Animal; Gene Deletion; Humans; Hyperbaric Oxygenation; Lens, Crystalline; Light; Methionine; Methionine Sulfoxide Reductases; Mice; Mice, Knockout; Mitochondrial Proteins; Oxidation-Reduction; Oxidative Stress; Oxidoreductases; Scattering, Radiation; Spectrometry, Mass, Electrospray Ionization | 2009 |
Raloxifene ameliorates detrimental enzymatic and nonenzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia.
Topics: Animals; Arginine; Bone and Bones; Bone Density; Bone Density Conservation Agents; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycation End Products, Advanced; Hyperhomocysteinemia; Lysine; Methionine; Osteoporosis; Rabbits; Raloxifene Hydrochloride; Stress, Mechanical | 2010 |
Behavioral changes in rats induced by a dipeptidyl peptidase IV inhibitor methionyl-2(S)-cyanopyrrolidine: experimental model of anxiety-depression disorder.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Male; Methionine; Pyrrolidines; Rats; Rats, Wistar | 2009 |
High dietary methionine plus cholesterol stimulates early atherosclerosis and late fibrous cap development which is associated with a decrease in GRP78 positive plaque cells.
Topics: Animals; Aorta, Abdominal; Atherosclerosis; Cholesterol; Cholesterol, Dietary; Coronary Artery Disease; Diet, Atherogenic; Disease Models, Animal; Disease Progression; Endoplasmic Reticulum Chaperone BiP; Endothelium, Vascular; Heat-Shock Proteins; Male; Methionine; Organ Culture Techniques; Rabbits | 2009 |
Children's toxicology from bench to bed--Liver Injury (2): Mechanism of antioxidant therapy for nonalcoholic fatty liver disease.
Topics: alpha-Tocopherol; Animals; Antioxidants; Carrier Proteins; Choline Deficiency; Disease Models, Animal; Fatty Liver; Liver; Male; Methionine; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Vitamin E | 2009 |
Teucrium polium in prevention of steatohepatitis in rats.
Topics: Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Choline Deficiency; Disease Models, Animal; Fatty Liver; Hepatitis; Lipoproteins; Liver; Male; Methionine; Oxidoreductases; Plant Extracts; Rats; Teucrium | 2009 |
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis.
Topics: Actins; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Choline Deficiency; Diabetes Complications; Disease Models, Animal; Enzyme Inhibitors; Fatty Liver; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Obese; Obesity | 2009 |
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Liver; Female; Homocysteine; Liver; Liver Neoplasms; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Unfolded Protein Response | 2009 |
One-carbon metabolism-genome interactions in folate-associated pathologies.
Topics: Animals; Carbon; Child; Developmental Disabilities; Disease Models, Animal; Environment; Folic Acid; Gastrointestinal Neoplasms; Genetic Phenomena; Genome, Human; Homocysteine; Humans; Methionine; Mice; Neural Tube Defects; Purines; Risk Factors; Thymidine Monophosphate | 2009 |
Heme oxygenase-1 protects against steatohepatitis in both cultured hepatocytes and mice.
Topics: Animals; Cell Line; Cells, Cultured; Disease Models, Animal; Fatty Liver; Heme Oxygenase-1; Hemin; Hepatocytes; Liver; Male; Mesoporphyrins; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha; Sterol Regulatory Element Binding Protein 1 | 2010 |
In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Humans; Male; Maze Learning; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress | 2010 |
IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis.
Topics: Animal Feed; Animals; Apoptosis; Choline; Disease Models, Animal; Fatty Liver; Inflammation; Interleukin-6; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; PPAR gamma | 2009 |
Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet.
Topics: Animals; Choline; Disease Models, Animal; Endoplasmic Reticulum; Fatty Liver; Inflammation; Liver Cirrhosis; Male; Methionine; Oxidative Stress; Rats; Rats, Wistar | 2010 |
Farnesyltransferase inhibitor improved survival following endotoxin challenge in mice.
Topics: Animals; Apoptosis; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Liver; Male; MAP Kinase Kinase 4; Methionine; Mice; Mice, Inbred C57BL; Simvastatin; Spleen | 2010 |
Moderate or supranormal folic acid supplementation does not exert a protective effect for homocysteinemia and methylation markers in growing rats.
Topics: Analysis of Variance; Animals; Biomarkers; Chromatography, High Pressure Liquid; Diet; Dietary Supplements; Disease Models, Animal; DNA Methylation; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Glutathione; Homocysteine; Male; Methionine; Rats; Rats, Sprague-Dawley; Vitamin B Complex | 2010 |
[Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats].
Topics: Animals; Apoptosis; Caspases; Cell Proliferation; Choline; Choline Deficiency; Diet; Disease Models, Animal; Endoplasmic Reticulum; Fatty Liver; Liver; Liver Cirrhosis; Male; Methionine; Random Allocation; Rats; Rats, Wistar; RNA, Messenger | 2010 |
Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling.
Topics: Adiponectin; Animals; Apoptosis; Choline Deficiency; Cytokines; Disease Models, Animal; Fatty Liver; Hepatectomy; Hepatocytes; Kupffer Cells; Ligation; Liver Regeneration; Male; Methionine; Portal Vein; PPAR alpha; Preoperative Care; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Adiponectin; RNA, Messenger; Signal Transduction; Technetium Tc 99m Disofenin | 2010 |
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet.
Topics: Adaptor Proteins, Signal Transducing; Animals; Body Weight; Choline Deficiency; Cytoskeletal Proteins; Disease Models, Animal; Fatty Acids; Fatty Liver; Genotype; Glutathione; Glutathione Transferase; Isoenzymes; Kelch-Like ECH-Associated Protein 1; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Organ Size; Phenotype; RNA, Messenger; Severity of Illness Index; Signal Transduction | 2010 |
Ameliorative role of rosiglitazone in hyperhomocysteinemia-induced experimental cardiac hypertrophy.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Homocysteine; Hyperhomocysteinemia; Hypertrophy, Left Ventricular; Male; Methionine; Oxidative Stress; PPAR gamma; Rats; Rats, Wistar; Rosiglitazone; Thiazolidinediones | 2010 |
L-methionine decreases dendritic spine density in mouse frontal cortex.
Topics: Animals; Anticonvulsants; Cell Adhesion Molecules, Neuronal; Cell Differentiation; Cell Shape; Dendritic Spines; Disease Models, Animal; Down-Regulation; Drug Interactions; Extracellular Matrix Proteins; Frontal Lobe; GABA Agents; Male; Methionine; Methylation; Mice; Nerve Tissue Proteins; Neuroprotective Agents; Neurotoxins; Reelin Protein; Schizophrenia; Serine Endopeptidases; Synapses; Valproic Acid | 2010 |
Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Collagen Type I; Dietary Fats; Dietary Fats, Unsaturated; Disease Models, Animal; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR gamma; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2010 |
Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice.
Topics: Analysis of Variance; Animals; Anxiety; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Humans; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Music Therapy; Noise; Polymorphism, Single Nucleotide; Receptor, trkB; RNA, Messenger | 2010 |
Severe In vivo hyper-homocysteinemia is not associatedwith elevation of amyloid-beta peptides in the Tg2576 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Humans; Hyperhomocysteinemia; Methionine; Mice; Mice, Transgenic; Peptide Fragments; Random Allocation; Vitamin B 12 | 2010 |
Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspase Inhibitors; Choline Deficiency; Cysteine Proteinase Inhibitors; Dietary Fats; Disease Models, Animal; Fatty Liver; Humans; Male; Methionine; Mice; Mice, Inbred C3H; Mice, Obese; Oxidative Stress | 2010 |
Stress signaling in the methionine-choline-deficient model of murine fatty liver disease.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 12; Choline Deficiency; Disease Models, Animal; DNA-Binding Proteins; Fatty Liver; Genes, MHC Class II; JNK Mitogen-Activated Protein Kinases; Liver; Male; Methionine; Mice; Mice, Inbred C3H; Oxidative Stress; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors; Triglycerides | 2010 |
Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/Akt/endothelial nitric oxide synthase signalling.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Cell Culture Techniques; Cell Line; Disease Models, Animal; Endothelium, Vascular; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A; Vasodilation | 2010 |
Potential role of Ras in cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; MAP Kinase Signaling System; Methionine; Rabbits; Random Allocation; ras Proteins; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2010 |
Functional interactions between the LRP6 WNT co-receptor and folate supplementation.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Folic Acid; Gene Expression; Gene Expression Regulation, Developmental; Immunohistochemistry; LDL-Receptor Related Proteins; Low Density Lipoprotein Receptor-Related Protein-6; Methionine; Mice; Mice, Inbred C3H; Mitochondria; Mutation; Neural Crest; Neural Tube Defects; NIH 3T3 Cells; Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Signal Transduction; Wnt Proteins | 2010 |
Danshensu protects vascular endothelia in a rat model of hyperhomocysteinemia.
Topics: Animals; Aorta, Thoracic; Atherosclerosis; Cardiovascular Agents; Diet; Disease Models, Animal; Endothelins; Endothelium, Vascular; Female; Hyperhomocysteinemia; Intercellular Adhesion Molecule-1; Lactates; Male; Methionine; Nitric Oxide; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2010 |
Increased susceptibility to experimental steatohepatitis induced by methionine-choline deficiency in HBs-Tg mice.
Topics: Alanine Transaminase; Animal Feed; Animals; Choline Deficiency; Disease Models, Animal; Disease Susceptibility; Fatty Liver; Hepatitis B Surface Antigens; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proliferating Cell Nuclear Antigen; Statistics, Nonparametric | 2010 |
Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Humans; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Vitamin B Deficiency | 2011 |
Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis.
Topics: Animals; D-Amino-Acid Oxidase; Disease Models, Animal; Electrophoresis, Capillary; Ischemia; Kidney; Ligands; Male; Methionine; Rats; Rats, Sprague-Dawley | 2012 |
Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Cell Proliferation; Choline Deficiency; Constitutive Androstane Receptor; Disease Models, Animal; Fatty Liver; Genes, myc; Hep G2 Cells; Humans; Ki-67 Antigen; Liver Neoplasms, Experimental; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Pyridines; Receptors, Cytoplasmic and Nuclear | 2011 |
Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by (1) H-magnetic resonance spectroscopy in a rat model.
Topics: Animals; Antioxidants; Choline Deficiency; Chromatography, Gas; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-3; Fatty Liver; Inflammation Mediators; Interleukin-6; Lipid Metabolism; Liver; Magnetic Resonance Spectroscopy; Male; Methionine; Rats; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Biopsy; Choline Deficiency; Cytokines; Disease Models, Animal; Fatty Liver; Female; Humans; Interferon Type I; Liver; Methionine; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Poly I-C; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Double-Stranded | 2011 |
Protection against acoustic trauma by direct application of D-methionine to the inner ear.
Topics: Administration, Topical; Animals; Auditory Threshold; Disease Models, Animal; Ear, Inner; Female; Guinea Pigs; Hearing Loss, Noise-Induced; Methionine; Treatment Outcome | 2011 |
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.
Topics: Animals; Apoptosis; Caspase 1; Choline Deficiency; Dietary Fats; Disease Models, Animal; Endotoxins; Fatty Acids; Fatty Liver; Female; Hepatocytes; Immune System; Inflammasomes; Interleukin-1beta; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2011 |
The effect of hepatic ischemia reperfusion injury in a murine model of nonalcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Diet; Disease Models, Animal; Disease Progression; Fatty Liver; Ischemia; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Peroxidase; Reperfusion Injury | 2011 |
Hyperhomocysteinemia inhibited cardiac stem cell homing into the peri-infarcted area post myocardial infarction in rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Movement; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Homocysteine; Hyperhomocysteinemia; Immunohistochemistry; Male; Methionine; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stem Cell Factor; Stem Cells | 2011 |
Low-dose D-methionine and N-acetyl-L-cysteine for protection from permanent noise-induced hearing loss in chinchillas.
Topics: Acetylcysteine; Animals; Auditory Threshold; Chinchilla; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Evoked Potentials, Auditory, Brain Stem; Female; Hearing Loss, Noise-Induced; Injections, Intraperitoneal; Methionine; Random Allocation; Reference Values; Treatment Outcome | 2011 |
D-methionine (D-met) significantly rescues noise-induced hearing loss: timing studies.
Topics: Acoustic Stimulation; Animals; Brain Stem; Chinchilla; Cytoprotection; Disease Models, Animal; Drug Administration Schedule; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Male; Methionine; Protective Agents; Time Factors | 2011 |
Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet.
Topics: Alanine Transaminase; Animals; Bezafibrate; Calcium Channel Blockers; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Hypolipidemic Agents; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Nifedipine; Non-alcoholic Fatty Liver Disease; PPAR gamma; Rats; Rats, Wistar | 2012 |
Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Clorgyline; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hydroxyindoleacetic Acid; Inositol 1,4,5-Trisphosphate Receptors; Methionine; Mice; Mice, Transgenic; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutation; Neuroblastoma; Neurons; Neurotransmitter Agents; Organic Chemicals; Presenilin-1; Serotonin; Subcellular Fractions; Swimming; Transfection; Valine; Voltage-Dependent Anion Channels | 2012 |
Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Female; Hippocampus; Methionine; Methionine Sulfoxide Reductases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neuroprotective Agents; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2011 |
Decreased accumulation of ultrasound contrast in the liver of nonalcoholic steatohepatitis rat model.
Topics: Animals; Body Weight; Choline Deficiency; Contrast Media; Diet; Disease Models, Animal; Fatty Liver; Kupffer Cells; Leptin; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Ultrasonography | 2011 |
Steatotic liver: a suitable source for the isolation of hepatic progenitor cells.
Topics: Animals; Antigens, Differentiation; Antigens, Neoplasm; Biomarkers; Cell Adhesion Molecules; Cell Separation; Choline Deficiency; Disease Models, Animal; Epithelial Cell Adhesion Molecule; Fatty Liver; Flow Cytometry; Humans; Liver; Male; Methionine; Rats; Stem Cells; Thy-1 Antigens; Time Factors | 2011 |
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Deficiency; Disease Models, Animal; DNA, Mitochondrial; Fatty Acids, Nonesterified; Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Humans; Liver; Lysosomes; Membrane Potential, Mitochondrial; Methionine; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Stress; PPAR gamma; Rats; Rats, Inbred OLETF; Rats, Long-Evans; RNA, Messenger; Thioctic Acid; Time Factors | 2011 |
A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; DNA-Binding Proteins; Fatty Liver; Feasibility Studies; Gene Expression Regulation; Liver Transplantation; Male; Methionine; Mice; Mice, SCID; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; Phenotype; Tumor Necrosis Factor-alpha | 2012 |
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cytochrome P-450 CYP2E1; Diet; Disease Models, Animal; Endoplasmic Reticulum Stress; Fatty Liver; Humans; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Thiobarbituric Acid Reactive Substances; Thioctic Acid | 2012 |
Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.
Topics: Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Blood Coagulation; Cystathionine beta-Synthase; Diet; Dietary Supplements; Disease Models, Animal; Homocysteine; Homocystinuria; Interleukin-1beta; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Thrombosis; Tumor Necrosis Factor-alpha | 2012 |
Regulation of physiologic actions of LRRK2: focus on autophagy.
Topics: Animals; Animals, Genetically Modified; Autophagy; Caenorhabditis elegans; Disease Models, Animal; Gene Expression Regulation; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Methionine; Mutation; Parkinson Disease; Protein Serine-Threonine Kinases; Sirolimus; tau Proteins; Valine | 2012 |
Methionine sulfoxide reductases and methionine sulfoxide in the subterranean mole rat (Spalax): characterization of expression under various oxygen conditions.
Topics: Animals; Base Sequence; Brain; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hyperoxia; Hypoxia; Liver; Male; Methionine; Methionine Sulfoxide Reductases; Molecular Sequence Annotation; Oxidation-Reduction; Oxygen; RNA, Messenger; Spalax; Time Factors; Transcription, Genetic | 2012 |
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.
Topics: Analysis of Variance; Animals; Bile Acids and Salts; Biopsy, Needle; Cells, Cultured; Diet; Disease Models, Animal; Fatty Liver; Hepatocytes; Homeostasis; Immunohistochemistry; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phospholipids; Polymerase Chain Reaction; Random Allocation | 2012 |
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Topics: Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Choline; Colon; Cytoskeletal Proteins; Disease Models, Animal; Disease Progression; Fatty Liver; Inflammasomes; Inflammation; Interleukin-18; Male; Metagenome; Methionine; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Obesity; Receptors, Cell Surface; RNA, Ribosomal, 16S; Toll-Like Receptor 4; Toll-Like Receptor 9; Tumor Necrosis Factor-alpha | 2012 |
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice.
Topics: Alcohols; Animals; Biopsy, Needle; Blotting, Western; Disease Models, Animal; Fatty Liver, Alcoholic; Immunohistochemistry; Lipid Peroxidation; Male; Methionine; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; One-Carbon Group Transferases; Oxidative Stress; Random Allocation; Severity of Illness Index; Species Specificity | 2012 |
Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Choline Deficiency; Cytoskeletal Proteins; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Iron; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Liver; Male; Methionine; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Real-Time Polymerase Chain Reaction; Sulfoxides; Thiocyanates | 2012 |
Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress.
Topics: Animals; Ascorbic Acid; Choline Deficiency; Diet; Disease Models, Animal; Ethylenediamines; Fatty Liver; Humans; Lipid Peroxidation; Methionine; Organometallic Compounds; Oxidative Stress; Rats; Salicylates | 2012 |
Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
Topics: Amination; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, Gas; Chromatography, Liquid; Cystathionine gamma-Lyase; Diet; Disease Models, Animal; Electrophoresis, Capillary; Hyperhomocysteinemia; Mass Spectrometry; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction | 2012 |
Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Corticosterone; Corticotropin-Releasing Hormone; Dendritic Spines; Depression; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Exploratory Behavior; Food Preferences; Gene Expression Regulation; Male; Maze Learning; Methionine; Mice; Mice, Transgenic; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-ets; Pyramidal Cells; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Silver Staining; Stress, Psychological; Sucrose; Sweetening Agents; Swimming; Valine | 2012 |
Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alz
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Humans; Leucine; Methionine; Mice; Mice, Transgenic; Molecular Sequence Data; Oxidative Stress; Proteins; Proteomics | 2012 |
Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia.
Topics: Animals; Annexin A2; Blood Coagulation; Bone Marrow Transplantation; Disease Models, Animal; Fibrinolysin; Fibrinolysis; Homocysteine; Hyperhomocysteinemia; Leukemia, Promyelocytic, Acute; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Recombinant Proteins; Tissue Plasminogen Activator | 2012 |
Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Choline Deficiency; Disease Models, Animal; Fatty Liver; Homeostasis; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Obese; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Silybin; Silymarin; Translational Research, Biomedical | 2012 |
p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.
Topics: Animals; Apoptosis; Caspase 3; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Disease Progression; Fatty Liver; Hepatocytes; Humans; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Up-Regulation | 2012 |
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.
Topics: Alanine Transaminase; Animals; Antimycin A; Apoptosis; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Free Radical Scavengers; Glutathione; Hepatocytes; Hydrogen Peroxide; Male; Metalloporphyrins; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitochondria, Liver; Oxidation-Reduction; Pentanoic Acids; Peroxiredoxin III; Primary Cell Culture; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Thioredoxins | 2012 |
Altered arsenic disposition in experimental nonalcoholic fatty liver disease.
Topics: Animals; Arsenates; Arsenic Trioxide; Arsenicals; Biotransformation; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Environmental Pollutants; Fatty Liver; Kidney; Liver; Male; Methionine; Methyltransferases; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Oxides | 2012 |
Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Choline Deficiency; Diet; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; GATA4 Transcription Factor; Glucagon-Like Peptide 1; Jejunum; Lipid Metabolism; Liver Cirrhosis; Male; Methionine; Mice; Mice, Knockout; Protein Kinases; Sterol Regulatory Element Binding Protein 1; Thiobarbituric Acid Reactive Substances; Triglycerides | 2012 |
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Collagen Type I; Collagen Type III; Cyclooxygenase 2; Diet; Disease Models, Animal; Fatty Liver; Fibrosis; HMGB1 Protein; Inflammation; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Quercetin; RNA, Messenger; Smad Proteins; Thiobarbituric Acid Reactive Substances; Toll-Like Receptor 4; Up-Regulation | 2012 |
Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease.
Topics: Adenosylhomocysteinase; Animals; Betaine; Copper; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Down-Regulation; Endoplasmic Reticulum Stress; Epigenesis, Genetic; Hepatolenticular Degeneration; Inflammation; Liver; Methionine; Mice; Mice, Inbred C3H; Penicillamine; S-Adenosylhomocysteine | 2013 |
Correlation of plasma amino acid concentrations and chondroprotective effects of glucosamine and fish collagen peptide on the development of osteoarthritis.
Topics: Alanine; Animals; Cartilage, Articular; Collagen; Disease Models, Animal; Female; Glucosamine; Histocytochemistry; Leucine; Methionine; Osteoarthritis; Rabbits; Statistics, Nonparametric | 2013 |
The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Intracellular Signaling Peptides and Proteins; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha | 2013 |
Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production.
Topics: Animals; Chemokine CCL2; Chemokine CXCL10; Choline; Diet; Disease Models, Animal; Fatty Liver; Female; Humans; Kupffer Cells; Methionine; Mice; Mice, Inbred C57BL; Monocytes; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2012 |
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
Topics: Animals; Biomarkers; Choline; Cysteine; Disease Models, Animal; Folic Acid Deficiency; Heterozygote; Homocysteine; Isoenzymes; Liver; Male; Methionine; Methylation; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutagenesis, Insertional; Mutant Proteins; Random Allocation | 2013 |
Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Choline Deficiency; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Hepatocytes; In Vitro Techniques; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Neovascularization, Pathologic; Non-alcoholic Fatty Liver Disease; Placenta Growth Factor; Pregnancy Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Diet, Fat-Restricted; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred A; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Specific Pathogen-Free Organisms; Time Factors | 2013 |
Changes in the hepatic mitochondrial and membrane proteome in mice fed a non-alcoholic steatohepatitis inducing diet.
Topics: Animals; Cations; Cell Membrane; Cholesterol; Diet; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Female; Fibrosis; Gene Expression Profiling; Glutathione Transferase; Glycerol; Inflammation; Lipids; Liver; Mass Spectrometry; Methionine; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Polyamines; Proteome; Proteomics; Urea | 2013 |
PTSD risk is associated with BDNF Val66Met and BDNF overexpression.
Topics: Adolescent; Adult; Afghan Campaign 2001-; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Female; Gene Expression Regulation; Genotype; Humans; Iraq War, 2003-2011; Male; Methionine; Middle Aged; Military Personnel; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Rats; Reflex, Startle; Stress Disorders, Post-Traumatic; Valine; Young Adult | 2014 |
14C-Methionine uptake as a potential marker of inflammatory processes after myocardial ischemia and reperfusion.
Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Autoradiography; Biomarkers; Carbon Radioisotopes; Disease Models, Animal; Immunohistochemistry; Inflammation; Male; Methionine; Myocardial Reperfusion Injury; Radiography; Rats; Rats, Wistar; Troponin I | 2013 |
Quercetin decreases liver damage in mice with non-alcoholic steatohepatitis.
Topics: Animals; Antioxidants; Choline Deficiency; Comet Assay; Diet; Disease Models, Animal; DNA Damage; Fatty Liver; Lipid Peroxidation; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; Molecular Structure; Oxidative Stress; Quercetin | 2013 |
Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation.
Topics: Animals; Brain; Cerebral Hemorrhage; Dementia, Vascular; Diet; Disease Models, Animal; Folic Acid; Humans; Hyperhomocysteinemia; Inflammation; Interleukin-1beta; Interleukin-6; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Memory Disorders; Methionine; Mice; Mice, Inbred C57BL; Vitamin B 12; Vitamin B 6 | 2013 |
Effect of hyperhomocysteinemia on protein C activation and activity.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; Enzyme Activation; Factor V; Female; Haplorhini; Humans; Hyperhomocysteinemia; Male; Methionine; Mice; Mice, Inbred C57BL; Partial Thromboplastin Time; Protein C; Thrombin | 2002 |
Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss.
Topics: Acetylcarnitine; Analysis of Variance; Animals; Audiometry; Auditory Threshold; Chinchilla; Cochlea; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Hair Cells, Auditory; Hearing Loss, Noise-Induced; Methionine; Nootropic Agents; Oxidative Stress | 2002 |
Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice.
Topics: Animals; Arterioles; Basement Membrane; Blood Pressure; Brain; Collagen; Cystathionine beta-Synthase; Diet; Disease Models, Animal; Elastin; Genotype; Heterozygote; Hyperhomocysteinemia; Hypertrophy; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Vascular Patency | 2002 |
Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media.
Topics: Animals; Butadienes; Disease Models, Animal; Ear, Middle; Enzyme Inhibitors; Haemophilus Infections; Haemophilus influenzae; Hyperplasia; In Vitro Techniques; Male; Methionine; Mitogen-Activated Protein Kinases; Mucous Membrane; Nitriles; Otitis Media; ras Proteins; Rats; Signal Transduction; Time Factors | 2002 |
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability.
Topics: Acetylation; Animals; Cell Adhesion Molecules, Neuronal; CpG Islands; Disease Models, Animal; Disease Susceptibility; DNA Methylation; Down-Regulation; Extracellular Matrix Proteins; Glutamate Decarboxylase; Histones; Isoenzymes; Methionine; Mice; Mice, Neurologic Mutants; Nerve Tissue Proteins; Promoter Regions, Genetic; Reelin Protein; Reflex, Startle; RNA, Messenger; Schizophrenia; Serine Endopeptidases; Valproic Acid | 2002 |
L-methionine supplementation accelerates tumour growth and shifts the phospholipid derivative pattern in a murine model of malignant melanoma. A proton HRMAS NMR spectroscopy study.
Topics: Animals; Cell Division; Dietary Supplements; Disease Models, Animal; Magnetic Resonance Spectroscopy; Male; Melanoma; Methionine; Methylation; Mice; Mice, Inbred C57BL; Phospholipids | 2002 |
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice.
Topics: Animals; Betaine; Central Nervous System Depressants; Disease Models, Animal; Endoplasmic Reticulum; Ethanol; Fatty Liver, Alcoholic; Gastrointestinal Agents; Gene Expression; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis | 2003 |
Combination therapy with folic acid and methionine in the prevention of retinoic acid-induced cleft palate in mice.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Cleft Palate; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Folic Acid; Injections, Intraperitoneal; Methionine; Mice; Pregnancy; Teratogens; Tretinoin | 2003 |
Brain energy metabolism is compromised by the metabolites accumulating in homocystinuria.
Topics: Animals; Brain; Carbon Dioxide; Disease Models, Animal; Electron Transport Complex IV; Energy Metabolism; Glucose; Hippocampus; Homocysteine; Homocystinuria; Methionine; Rats; Rats, Wistar | 2003 |
Ameliorative effect of L-methionine on Pb-exposed mice.
Topics: Animals; Antioxidants; Body Weight; Brain Chemistry; Disease Models, Animal; Female; Growth; Hematopoietic System; Iron; Kidney; Lead; Lipid Peroxidation; Liver; Male; Methionine; Mice; Organ Size; Oxidative Stress; Spleen | 2003 |
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.
Topics: Alkyl and Aryl Transferases; Animals; Antiviral Agents; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis D; Hepatitis Delta Virus; Humans; Methionine; Mice; Mice, Transgenic; Oligopeptides; Protein Prenylation; RNA Editing; Viremia; Virus Replication | 2003 |
Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies.
Topics: Alanine Transaminase; Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Female; Lipid Peroxidation; Liver; Male; Malnutrition; Methionine; Mice; Mice, Inbred C57BL; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Sex Factors; Species Specificity | 2003 |
MtaR, a regulator of methionine transport, is critical for survival of group B streptococcus in vivo.
Topics: Animals; Animals, Newborn; Bacterial Proteins; Disease Models, Animal; Gene Expression Regulation, Bacterial; Humans; Methionine; Mutation; Rats; Sepsis; Streptococcal Infections; Streptococcus agalactiae; Transcription Factors | 2003 |
Nutritional and technological evaluation of an enzymatically methionine-enriched soy protein for infant enteral formulas.
Topics: Amino Acids; Animals; Disease Models, Animal; Female; Food, Fortified; Humans; Hydrolysis; Infant; Infant Food; Male; Malnutrition; Methionine; Nutritive Value; Rats; Rats, Wistar; Soybean Proteins; Viscosity | 2004 |
Comparison of post-translational modifications of alpha A-crystallin from normal and hereditary cataract rats.
Topics: Aging; alpha-Crystallin A Chain; Animals; Aspartic Acid; Cataract; Disease Models, Animal; Humans; Isomerism; Lens, Crystalline; Methionine; Molecular Structure; Oxidation-Reduction; Peptides; Protein Processing, Post-Translational; Rats; Rats, Mutant Strains; Rats, Wistar; Time Factors | 2004 |
The S-adenosyl homocysteine hydrolase inhibitor 3-deaza-adenosine prevents oxidative damage and cognitive impairment following folate and vitamin E deprivation in a murine model of age-related, oxidative stress-induced neurodegeneration.
Topics: Adenosylhomocysteinase; Animals; Apolipoproteins E; Brain; Brain Chemistry; Cognition Disorders; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Female; Folic Acid Deficiency; Homocysteine; Male; Methionine; Mice; Mice, Knockout; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Tubercidin; Vitamin E Deficiency | 2004 |
Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats.
Topics: Acetylation; Animals; Carbon; Chromatin; Cystathionine beta-Synthase; Disease Models, Animal; Disease Susceptibility; DNA Methylation; Enzyme Induction; Female; Fetal Growth Retardation; Gene Expression Regulation, Developmental; Gestational Age; Histones; Liver; Methionine; Methionine Adenosyltransferase; Placental Circulation; Placental Insufficiency; Pregnancy; Protein Processing, Post-Translational; Rats; S-Adenosylhomocysteine | 2004 |
Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation.
Topics: Amino Acids, Sulfur; Animals; Base Sequence; Collagen; Cysteine; Disease Models, Animal; DNA Primers; Fibroblasts; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Thioacetamide | 2004 |
Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcholine; Animals; Arterioles; Cerebrovascular Disorders; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Hyperhomocysteinemia; Methionine; Mice; Nitroprusside; Oxidative Stress; Superoxides; Vasodilation; Vasodilator Agents | 2004 |
Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin.
Topics: Animals; Cell Line; Choline Deficiency; Deficiency Diseases; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Liver; Female; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Osteopontin; Receptors, Cell Surface; Receptors, Leptin; Sialoglycoproteins | 2004 |
Temporal evaluation of methionine synthase and related metabolites in the MAC15A mouse adenocarcinoma animal model.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carcinoma; Cell Division; Disease Models, Animal; Disease Progression; Humans; Methionine; Methylation; Mice | 2004 |
Rodent Abeta(1-42) exhibits oxidative stress properties similar to those of human Abeta(1-42): Implications for proposed mechanisms of toxicity.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Free Radical Scavengers; Humans; Lipid Bilayers; Methionine; Molecular Sequence Data; Neurons; Oxidative Stress; Peptide Fragments; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2004 |
An alphaTropomyosin mutation alters dimer preference in nemaline myopathy.
Topics: Animals; Animals, Newborn; Arginine; Blotting, Northern; Blotting, Western; Dimerization; Disease Models, Animal; DNA Mutational Analysis; Gene Expression Regulation; Humans; Methionine; Mice; Mice, Transgenic; Muscle, Skeletal; Mutation; Myopathies, Nemaline; Promoter Regions, Genetic; Protein Structure, Secondary; Recombinant Proteins; RNA, Messenger; Time Factors; Tropomyosin | 2005 |
Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats.
Topics: Animals; Betaine; Disease Models, Animal; Glycine; Homocysteine; Hyperhomocysteinemia; Injections, Intravenous; Male; Methionine; Rats; Sarcosine | 2004 |
A comparison of the effects of betaine and S-adenosylmethionine on ethanol-induced changes in methionine metabolism and steatosis in rat hepatocytes.
Topics: Animals; Betaine; Disease Models, Animal; Ethanol; Fatty Liver; Hepatocytes; Male; Methionine; Methyltransferases; Microsomes, Liver; Phosphatidylethanolamine N-Methyltransferase; Rats; Rats, Wistar; S-Adenosylmethionine | 2005 |
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.
Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blotting, Western; Cell Adhesion Molecules, Neuronal; Chromosome Mapping; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Epilepsy; Extracellular Matrix Proteins; Frontal Lobe; GABA Modulators; Histones; Imidazoles; Immunohistochemistry; Interpersonal Relations; Male; Methionine; Methylation; Mice; Motor Activity; Nerve Tissue Proteins; Neural Inhibition; Promoter Regions, Genetic; Reelin Protein; Reflex, Startle; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Schizophrenia; Serine Endopeptidases; Time Factors; Valproic Acid | 2005 |
Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.
Topics: Animals; Animals, Newborn; Arginine; Blotting, Western; Brain; Cells, Cultured; Cerebellum; Cricetinae; Cricetulus; Detergents; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Gene Expression; Glial Fibrillary Acidic Protein; Golgi Apparatus; Golgi Matrix Proteins; Immunoprecipitation; Leucine; Membrane Proteins; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurodegenerative Diseases; Neurons; Octoxynol; Prion Diseases; Protein Structure, Tertiary; PrPSc Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfur Isotopes; Time Factors; Type C Phospholipases; Valine | 2005 |
Melatonin improves learning and memory performances impaired by hyperhomocysteinemia in rats.
Topics: Analysis of Variance; Animals; Avoidance Learning; Disease Models, Animal; Glutathione; Hippocampus; Hyperhomocysteinemia; Learning Disabilities; Lipid Peroxidation; Male; Maze Learning; Melatonin; Memory Disorders; Methionine; Neural Cell Adhesion Molecules; Rats; Rats, Wistar | 2005 |
Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Disease Models, Animal; DNA; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Extracellular Matrix Proteins; gamma-Aminobutyric Acid; Gene Expression; Globins; Glutamate Decarboxylase; Isoenzymes; Methionine; Methyl-CpG-Binding Protein 2; Mice; Models, Biological; Nerve Tissue Proteins; Promoter Regions, Genetic; Reelin Protein; Repressor Proteins; RNA, Messenger; Schizophrenia; Serine Endopeptidases | 2005 |
NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Inflammation Mediators; Intercellular Adhesion Molecule-1; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NF-kappa B; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biomarkers; Choline; Chromatography, High Pressure Liquid; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Heterozygote; Methionine; Mice; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Severity of Illness Index; Up-Regulation | 2006 |
Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy.
Topics: 3T3 Cells; Alleles; Amino Acid Substitution; Animals; Cells, Cultured; Crosses, Genetic; Disease Models, Animal; Embryonic Stem Cells; Female; Magnetic Resonance Spectroscopy; Methionine; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; Oxidoreductases Acting on CH-CH Group Donors; Phenotype; Simvastatin; Smith-Lemli-Opitz Syndrome; Threonine | 2006 |
Glutathione-enhancing agents protect against steatohepatitis in a dietary model.
Topics: Animals; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Food, Formulated; Inflammation; Lipotropic Agents; Male; Methionine; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Thiazoles; Transaminases | 2006 |
Rpe65 as a modifier gene for inherited retinal degeneration.
Topics: Age Factors; Animals; Carrier Proteins; cis-trans-Isomerases; Disease Models, Animal; Eye Proteins; Gene Expression Regulation, Developmental; Genetic Variation; Leucine; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Retina; Retinal Degeneration; Reverse Transcriptase Polymerase Chain Reaction; Rhodopsin; RNA, Messenger; Time Factors | 2006 |
Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency.
Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Fatty Liver; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Rats; Triglycerides; Tumor Necrosis Factor-alpha | 2006 |
Effects of depleting the essential central metabolic enzyme fructose-1,6-bisphosphate aldolase on the growth and viability of Candida albicans: implications for antifungal drug target discovery.
Topics: Animals; Antifungal Agents; Base Sequence; Candida albicans; Candidiasis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Fructose-Bisphosphate Aldolase; Methionine; Mice; Microbial Sensitivity Tests; Molecular Sequence Data | 2006 |
The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice.
Topics: Animals; Apolipoproteins E; Behavior, Animal; Brain; Cognition Disorders; Disease Models, Animal; Folic Acid Deficiency; Hyperhomocysteinemia; Male; Maze Learning; Methionine; Mice; Neuropsychological Tests; Nutrition Disorders; Psychomotor Performance; Severity of Illness Index; Space Perception; Vitamin B 12 Deficiency | 2006 |
The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Constitutive Androstane Receptor; Diet; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Knockout; Organ Size; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Translocation, Genetic | 2007 |
Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Methionine; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Quantitative Trait Loci | 2006 |
Chemically induced model of hypermethioninemia in rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Brain; Disease Models, Animal; Homocystinuria; Methionine; Rats; Rats, Wistar; Tissue Distribution | 2007 |
Diet-induced hyperhomocysteinemia does not lead to large gene-expression differences in rat aorta.
Topics: Animals; Aorta; Diet; Disease Models, Animal; Female; Gene Expression; Gene Expression Profiling; Hyperhomocysteinemia; Methionine; Microarray Analysis; Oxidative Stress; Rats; Rats, Wistar; Vascular Diseases | 2007 |
Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Fatty Liver; Female; Hydroxyproline; Iron Overload; Lipid Peroxidation; Liver; Methionine; Organ Size; Rats; Rats, Inbred F344 | 2006 |
NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis.
Topics: Animals; Chemokine CCL2; Chemokine CCL4; Choline; Choline Deficiency; Cyclooxygenase 2; Diet; Disease Models, Animal; Fatty Liver; Female; Gene Expression Regulation; Hepatitis; Intercellular Adhesion Molecule-1; Liver; Macrophage Inflammatory Proteins; Membrane Glycoproteins; Methionine; Mice; Mice, Mutant Strains; NADPH Oxidase 2; NADPH Oxidases; NF-kappa B; Oxidative Stress; RNA, Messenger; Tumor Necrosis Factor-alpha | 2007 |
Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.
Topics: Animal Feed; Animals; Choline; Collagen Type I; Collagen Type I, alpha 1 Chain; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, Animal; Fatty Liver; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Liver; Male; Methionine; Obesity; Pioglitazone; Plasminogen Activator Inhibitor 1; PPAR gamma; Rats; Rats, Inbred OLETF; Rats, Long-Evans; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Thiazolidinediones; Transforming Growth Factor beta; Up-Regulation | 2007 |
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Topics: Animals; Brain; Disease Models, Animal; Embryo, Mammalian; Female; Ferredoxin-NADP Reductase; Folic Acid; Heart; Homocysteine; Hyperhomocysteinemia; Kidney; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Protective effect of soy isoflavones and activity levels of plasma paraoxonase and arylesterase in the experimental nonalcoholic steatohepatitis model.
Topics: Animals; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Choline Deficiency; Disease Models, Animal; Fatty Liver; Glycine max; Hepatitis; Isoflavones; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Rats | 2007 |
CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis.
Topics: Acute-Phase Reaction; Animals; Body Weight; CCAAT-Enhancer-Binding Protein-beta; Choline Deficiency; Cytochrome P-450 CYP2E1; Diet; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum; Eukaryotic Initiation Factor-2; Fatty Liver; Inflammation; JNK Mitogen-Activated Protein Kinases; Lipase; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Transcription Factor CHOP; Tumor Necrosis Factor-alpha | 2007 |
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis.
Topics: Adiponectin; Animal Feed; Animals; Blood Glucose; Choline; Cytochrome P-450 CYP2E1; Diacylglycerol O-Acyltransferase; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; Hepatocytes; Insulin; Lipid Peroxidation; Liver Cirrhosis; Male; Methionine; Mice; Mice, Mutant Strains; Obesity; Oligoribonucleotides, Antisense; Oxidative Stress; Triglycerides; Tumor Necrosis Factor-alpha | 2007 |
Role of adipocytokines in hepatic fibrogenesis.
Topics: Adiponectin; Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Kupffer Cells; Leptin; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Oxidative Stress; Transforming Growth Factor beta1; Up-Regulation | 2007 |
Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.
Topics: Achondroplasia; Animals; Apoptosis; Cell Proliferation; Chondrocytes; Disease Models, Animal; Dwarfism; Endoplasmic Reticulum; Extracellular Matrix Proteins; Female; Glycoproteins; Male; Matrilin Proteins; Methionine; Mice; Mice, Knockout; Mutation; Osteochondrodysplasias; Phenotype; Protein Structure, Tertiary; Threonine | 2007 |
Testicular injury to rats fed on soybean protein-based vitamin B12-deficient diet can be reduced by methionine supplementation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Animals; Body Weight; Diet; Dietary Supplements; Disease Models, Animal; Female; Male; Methionine; Methylmalonic Acid; Organ Size; Rats; Rats, Wistar; Soybean Proteins; Testicular Diseases; Testis; Vitamin B 12 Deficiency | 2007 |
The use of an in vivo model to study the effects of hyperhomocysteinaemia on vascular function.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Folic Acid; Hyperhomocysteinemia; Male; Methionine; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.
Topics: Adult; Aged; Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Clorgyline; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Humans; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Severity of Illness Index; Tryptophan Hydroxylase; Up-Regulation | 2007 |
Not all models of fatty liver are created equal: understanding mechanisms of steatosis development is important.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Fatty Liver, Alcoholic; Humans; Methionine; Rats | 2007 |
Essential pathogenic and metabolic differences in steatosis induced by choline or methione-choline deficient diets in a rat model.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Insulin; Lipids; Liver; Male; Methionine; Oxidative Stress; Rats; Rats, Wistar | 2007 |
Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis.
Topics: Animal Feed; Animals; Antioxidants; Catalytic Domain; Choline Deficiency; Diet; Disease Models, Animal; Epoxide Hydrolases; Fatty Liver; Glutamate-Cysteine Ligase; Heme Oxygenase (Decyclizing); Male; Methionine; NAD(P)H Dehydrogenase (Quinone); Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Up-Regulation | 2007 |
S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet.
Topics: Animals; Body Weight; Disease Models, Animal; Ethanol; Fatty Liver; Female; Folic Acid; Folic Acid Deficiency; Linear Models; Liver; Liver Diseases, Alcoholic; Male; Methionine; Necrosis; Oxidative Stress; S-Adenosylmethionine; Swine; Swine, Miniature | 2007 |
Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation.
Topics: Animals; Choline Deficiency; Dietary Fats, Unsaturated; Disease Models, Animal; Down-Regulation; Fatty Acids; Fatty Acids, Omega-3; Fatty Liver; Female; Fish Oils; Gene Expression; Lipid Peroxides; Lipogenesis; Lipolysis; Liver; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha | 2008 |
Interstrain differences in susceptibility to non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Disease Susceptibility; Fatty Liver; Gene Expression; Lipid Metabolism; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Organ Size; RNA, Messenger; Species Specificity | 2008 |
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
Topics: Alanine Transaminase; Animals; ATPases Associated with Diverse Cellular Activities; Chromosome Mapping; Disease Models, Animal; Down-Regulation; Embryo, Mammalian; Female; Gene Expression; Gene Expression Profiling; Glycine N-Methyltransferase; Glycogen; Glycogen Storage Disease; Hepatitis, Chronic; Homocysteine; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Effects of rosiglitazone on methionine-choline deficient diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline; Diet; Disease Models, Animal; Fatty Liver; Liver; Methionine; Mice; Mitochondria, Liver; Rosiglitazone; Thiazolidinediones | 2007 |
The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Topics: Actins; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Aspartate Aminotransferases; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Hepatitis; Infliximab; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Male; Malondialdehyde; Methionine; Necrosis; Rats; Time Factors; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2008 |
The methionine connection: homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats.
Topics: Acetylcholine; Animals; Disease Models, Animal; Homocysteine; Hydrogen Sulfide; Hyperhomocysteinemia; Liver; Liver Circulation; Liver Cirrhosis; Male; Methionine; Microcirculation; Rats; Rats, Wistar | 2008 |
Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease.
Topics: Adiponectin; Adipose Tissue; Animals; Betaine; Cystathionine beta-Synthase; Disease Models, Animal; Endoplasmic Reticulum; Ethanol; Homocysteine; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Rats; Rats, Sprague-Dawley | 2008 |
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet.
Topics: Animals; Choline; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Food, Formulated; Glutathione; Hepatitis; Homeostasis; Lipid Metabolism; Liver; Methionine; Mice; Mice, Mutant Strains; Mice, Obese; Obesity; S-Adenosylmethionine | 2008 |
Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice.
Topics: Animals; Atherosclerosis; Diet, Atherogenic; Dietary Supplements; Disease Models, Animal; Female; Homocysteine; Hyaluronic Acid; Hyperhomocysteinemia; Immunohistochemistry; Lipids; Methionine; Mice; Mice, Inbred C57BL | 2008 |
Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Carnosine; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Hepatic Stellate Cells; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Methionine; Mice; Mice, Inbred C57BL; Organometallic Compounds; RNA, Messenger; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha; Zinc Compounds | 2008 |
Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Choline Deficiency; Disease Models, Animal; Fatty Acids; Fatty Liver; Imidazoles; Insulin Resistance; Liver Cirrhosis, Experimental; Male; Methionine; Oxidative Stress; Rats; Rats, Long-Evans; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Tetrazoles; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2008 |
Pathogenesis of subacute combined degeneration: a result of methyl group deficiency.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Humans; Macaca fascicularis; Methionine; Nitrous Oxide; Spinal Cord; Spinal Cord Diseases; Tetrahydrofolates; Vitamin B 12 | 1981 |
Large-pore hemodialytic procedures in pigs with ischemic hepatic necrosis; a randomized study.
Topics: Ammonia; Animals; Blood; Disease Models, Animal; Electroencephalography; Hepatic Encephalopathy; Ischemia; Liver; Methionine; Renal Dialysis; Swine; Ultrafiltration | 1984 |
Experimental homocysteinemia in pigs: comparison with studies in sixteen homocystinuric patients.
Topics: Adolescent; Adult; Amino Acids; Aminobutyrates; Animals; Child; Child, Preschool; Dipeptides; Disease Models, Animal; Homocysteine; Homocystine; Homocystinuria; Humans; Kinetics; Methionine; Middle Aged; Swine; Taurine | 1982 |
Impaired metabolism of methionine in severe liver diseases. II. Clinical and experimental studies on role of impaired methionine metabolism in pathogenesis of hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepatic Encephalopathy; Hepatitis; Humans; Liver Cirrhosis; Male; Methionine; Rats; Rats, Inbred Strains | 1982 |
Jejunal transport properties of piebald mouse model for Hirschsprung's disease.
Topics: Alanine; Amino Acids; Animals; Biological Transport, Active; Disease Models, Animal; Female; Jejunum; Male; Megacolon; Methionine; Mice; Mice, Mutant Strains; Sodium | 1980 |
Alterations of methionine fluxes and incorporation in intestines of miniature pigs fed a diet high in caseinate are restricted by angiotensin-converting enzyme inhibitor.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Caseins; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Epithelium; Homocysteine; Hydrochlorothiazide; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Methionine; Random Allocation; Sodium Chloride Symporter Inhibitors; Swine; Swine, Miniature; Tritium | 1995 |
Nicotinamide megadosing increases hepatic poly(ADP-ribose) levels in choline-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Choline; Choline Deficiency; Disease Models, Animal; Dose-Response Relationship, Drug; Food, Fortified; Liver; Male; Methionine; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Random Allocation; Rats; Rats, Inbred F344 | 1995 |
Increased lipid peroxidation as a mechanism of methionine-induced atherosclerosis in rabbits.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Catalase; Diet; Disease Models, Animal; Erythrocytes; Glutathione Peroxidase; Lipid Peroxidation; Male; Methionine; Rabbits; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 1995 |
Experimental thyrotoxic myopathy: radioautography of protein synthesis in skeletal muscle and motor neurons of spinal cord.
Topics: Animals; Autoradiography; Cell Count; Disease Models, Animal; Methionine; Mice; Motor Neurons; Muscle Proteins; Muscles; Spinal Cord; Thyrotoxicosis; Tritium | 1995 |
Effects of polymorphonuclear neutrophils on protein synthesis by alkali-injured rabbit corneas. A preliminary study.
Topics: Animals; Burns, Chemical; Cells, Cultured; Cornea; Corneal Injuries; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Eye Burns; Eye Proteins; Female; Male; Methionine; Neutrophils; Organ Culture Techniques; Rabbits; Sodium Hydroxide; Sulfur Radioisotopes; Wound Healing | 1993 |
A comparative study on protein incorporation of L-[methyl-3H]methionine, L-[1-14C]leucine and L-2-[18F]fluorotyrosine in tumor bearing mice.
Topics: Animals; Brain; Carbon Radioisotopes; Disease Models, Animal; Fluorine Radioisotopes; Hydrogen-Ion Concentration; Leucine; Lipid Metabolism; Mammary Neoplasms, Experimental; Methionine; Mice; Mice, Inbred C3H; Neoplasm Proteins; Nerve Tissue Proteins; Nucleic Acids; Solubility; Tissue Distribution; Tomography, Emission-Computed; Tritium; Tyrosine | 1993 |
Attenuation of ischemic acute renal failure by phosphoramidon in rats.
Topics: Acute Kidney Injury; Animals; Aspartic Acid Endopeptidases; Disease Models, Animal; Endothelin-Converting Enzymes; Endothelins; Glomerular Filtration Rate; Glycopeptides; Infusions, Intravenous; Male; Metalloendopeptidases; Methionine; Neprilysin; Rats | 1993 |
A rat fatty liver transplant model.
Topics: Animals; Choline Deficiency; Chromatography, Gas; Diet; Disease Models, Animal; Fatty Liver; Graft Survival; Lipids; Liver; Liver Diseases; Liver Transplantation; Male; Methionine; Necrosis; Postoperative Period; Rats; Rats, Inbred ACI; Time Factors | 1993 |
Improvement of hyperlipidemia and proteinuria without noticeable growth retardation by feeding a methionine and threonine supplemented low-casein diet to nephritic rats.
Topics: Animals; Caseins; Diet, Protein-Restricted; Disease Models, Animal; Food, Fortified; Hyperlipidemias; Hypolipidemic Agents; Male; Methionine; Microsomes, Liver; Nephritis; Proteinuria; Rats; Rats, Wistar; Threonine | 1995 |
Methionine reduces the valproic acid-induced spina bifida rate in mice without altering valproic acid kinetics.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Embryonic and Fetal Development; Female; Incidence; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Methionine; Mice; Neural Tube Defects; Spinal Dysraphism; Valproic Acid | 1996 |
[Influence of mycobacterium on adaptive rearrangement in guinea pigs long exposed to polycystic aromatic hydrocarbon-containing agents].
Topics: Adaptation, Biological; Animals; Arginine; Bone Marrow; Cell Membrane; Disease Models, Animal; Guinea Pigs; Liver; Lung; Methionine; Mycobacterium tuberculosis; Polycyclic Aromatic Hydrocarbons; Spleen; Tuberculosis | 1998 |
A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Chloride Channels; Disease Models, Animal; DNA Primers; Dogs; Electrophysiology; Genes, Recessive; Homozygote; Methionine; Molecular Sequence Data; Muscle, Skeletal; Mutation, Missense; Myotonia Congenita; Pedigree; Polymerase Chain Reaction; Recombinant Proteins; Sequence Homology, Amino Acid; Threonine | 1999 |
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Disease Models, Animal; Enzyme Inhibitors; Farnesyltranstransferase; Female; Genes, ras; Growth Inhibitors; Humans; Mammary Neoplasms, Animal; Mammary Tumor Virus, Mouse; Methionine; Mice; Mice, Transgenic; Phenotype; Transgenes | 2000 |
Pathology of familial amyloidotic polyneuropathy with TTR met 30 in Kumamoto, Japan.
Topics: Adult; Amyloid; Amyloid Neuropathies; Animals; Disease Models, Animal; Female; Humans; Japan; Male; Methionine; Mice; Mice, Transgenic; Middle Aged; Nerve Fibers; Point Mutation; Prealbumin; Sural Nerve | 2000 |
Effects of parenteral cysteine and glutathione feeding in a baboon model of severe prematurity.
Topics: Animals; Animals, Newborn; Cysteine; Disease Models, Animal; Fetal Blood; Gestational Age; Glutathione; Methionine; Papio; Parenteral Nutrition | 2000 |
Beneficial renal and cardiac effects of vasopeptidase inhibition with S21402 in heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Captopril; Cardiovascular System; Disease Models, Animal; Female; Heart Failure; Hormones; Kidney; Methionine; Myocardial Infarction; Neprilysin; Propionates; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Water | 2000 |
A mutation in alpha-tropomyosin(slow) affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy.
Topics: Amino Acid Substitution; Animals; Arginine; Disease Models, Animal; Dissection; Female; Glycolysis; Humans; Hypertrophy; Inclusion Bodies; Methionine; Mice; Mice, Inbred Strains; Mice, Transgenic; Microtubules; Muscle Development; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle Weakness; Muscle, Skeletal; Myopathies, Nemaline; Oxidation-Reduction; Point Mutation; RNA, Messenger; Sarcoplasmic Reticulum; Strontium; Tropomyosin | 2001 |
Chemopreventive efficacy of promising farnesyltransferase inhibitors.
Topics: 3T3 Cells; Adenoma; Alkyl and Aryl Transferases; Animals; Apoptosis; Chemoprevention; Dehydroepiandrosterone; Disease Models, Animal; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransferase; Fluorescent Antibody Technique, Indirect; Gliotoxin; In Situ Nick-End Labeling; Lung Neoplasms; Methionine; Mice; Mice, Inbred A; Mice, Inbred C3H; Monoterpenes; Polyenes; Polymerase Chain Reaction; Polyunsaturated Alkamides; Proliferating Cell Nuclear Antigen; Terpenes | 2000 |
Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model.
Topics: Animals; Apolipoproteins E; Arteriosclerosis; Cells, Cultured; Diet; Disease Models, Animal; Folic Acid; Humans; Hyperhomocysteinemia; Immunohistochemistry; Male; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyridoxine; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thromboplastin; Vascular Cell Adhesion Molecule-1; Vasculitis; Vitamin B 12 | 2001 |
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.
Topics: Animals; Cell Division; Disease Models, Animal; DNA Methylation; Gene Expression Regulation, Enzymologic; Genetic Predisposition to Disease; Liver; Liver Cirrhosis, Experimental; Methionine; Methionine Adenosyltransferase; Mice; Mice, Knockout; Phenotype | 2001 |
Antioxidant effects of alpha tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Brain; Chelating Agents; Disease Models, Animal; Edetic Acid; Kidney; Lead; Lipid Peroxides; Liver; Methionine; Organ Size; Oxidative Stress; Rats; Vitamin E | 2001 |
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Topics: Animals; Aorta; Brain; Chronic Disease; Cystathionine beta-Synthase; Disease Models, Animal; Endothelium, Vascular; Folic Acid; Food, Fortified; Heterozygote; Homocysteine; Hyperhomocysteinemia; In Vitro Techniques; Liver; Methionine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; S-Adenosylhomocysteine; S-Adenosylmethionine; Thrombomodulin; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 2001 |
Implications of hyperhomocysteinemia in glomerular sclerosis in hypertension.
Topics: Animals; Chromatography, High Pressure Liquid; Diet; Disease Models, Animal; Glomerular Mesangium; Homocysteine; Hyperhomocysteinemia; Hypertension; Methionine; Rats; Rats, Sprague-Dawley; Salts; Sclerosis | 2002 |
Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis.
Topics: Acute Disease; Animals; Benzamides; Brain; Cell Line; Cell Membrane; Cell Movement; Dimethylallyltranstransferase; Disease Models, Animal; Drug Combinations; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Guinea Pigs; Leukocytes; Methionine; Mice; Mice, Inbred Strains; Multiple Sclerosis; Myelin Basic Protein; Protein Prenylation; Rats; Rats, Inbred Lew; rho GTP-Binding Proteins; T-Lymphocytes | 2002 |
Cholesterol plus methionine feeding do not induce lipid peroxidation and atherosclerotic changes in the rat aorta.
Topics: Animals; Aorta; Arteriosclerosis; Catalase; Cholesterol, Dietary; Disease Models, Animal; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Methionine; Rats; Rats, Wistar; Superoxide Dismutase | 2002 |
Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.
Topics: Animal Feed; Animals; Blotting, Western; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cholesterol; Choline; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Disease Models, Animal; Fatty Liver; Hepatectomy; Liver; Liver Regeneration; Male; Methionine; Organ Size; Orotic Acid; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Rats, Zucker; Triglycerides | 2002 |
Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.
Topics: Animals; Disease Models, Animal; Ethanol; Folic Acid Deficiency; Humans; Liver; Liver Diseases, Alcoholic; Male; Methionine; Swine; Swine, Miniature | 2002 |
Round window application of D-methionine provides complete cisplatin otoprotection.
Topics: Administration, Topical; Animals; Audiometry; Auditory Threshold; Chinchilla; Cisplatin; Cochlea; Disease Models, Animal; Drug Interactions; Female; Hearing Loss, Sensorineural; Male; Methionine; Reference Values; Round Window, Ear; Sensitivity and Specificity | 2002 |
Animal studies--a theoretical basis for treatment.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Animals; Antidotes; Cysteine; Disease Models, Animal; Female; Male; Methionine; Mice; Nicotinic Acids; Sulfhydryl Compounds | 1976 |
Sulfur-containing amino acids in experimental hepatic coma in the dog and the monkey.
Topics: Amino Acids, Branched-Chain; Amino Acids, Sulfur; Animals; Brain Chemistry; Disease Models, Animal; Dogs; Haplorhini; Hepatic Encephalopathy; Macaca mulatta; Methionine; Portacaval Shunt, Surgical; Taurine | 1979 |
Effect of induced elevated plasma levels of homocystine and methionine in rats on collagen and elastin structures.
Topics: Animals; Collagen; Connective Tissue; Disease Models, Animal; Elastin; Female; Homocystine; Homocystinuria; Humans; Male; Methionine; Peptides; Rats; Solubility | 1976 |
Cerebral permeability phenomena in epilepsy.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Cell Membrane Permeability; Disease Models, Animal; Extracellular Space; Histidine; Methionine; Mice; Pentylenetetrazole; Rabbits; Seizures | 1976 |
Methionine-induced hepatic coma in dogs.
Topics: Administration, Oral; Ammonia; Animals; Brain; Disease Models, Animal; Dogs; Hepatic Encephalopathy; Infusions, Parenteral; Liver; Liver Cirrhosis; Liver Function Tests; Methionine; Portacaval Shunt, Surgical; Rats | 1975 |
Tumor diagnosis by PET: potential of seven tracers examined in five experimental tumors including an artificial metastasis model.
Topics: Animals; Carbon Radioisotopes; Deoxyglucose; Diagnosis, Differential; Disease Models, Animal; Floxuridine; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Fucose; Lung Neoplasms; Methionine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Thymidine; Tomography, Emission-Computed; Tritium | 1992 |
Restoration of antioxidants in liver by methionine feeding in experimental rat urolithiasis.
Topics: Animals; Antioxidants; Citrates; Citric Acid; Diet; Disease Models, Animal; Gallium; Lipid Peroxidation; Male; Methionine; Microsomes, Liver; Mitochondria, Liver; Rats; Rats, Wistar; Urinary Calculi | 1992 |
Protein phosphorylation in retinal pigment epithelium of Long-Evans and Royal College of Surgeons rats.
Topics: Animals; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Eye Proteins; Methionine; Microspheres; Phagocytosis; Phosphorus Radioisotopes; Phosphorylation; Pigment Epithelium of Eye; Rats; Rats, Mutant Strains; Retinal Degeneration; Rod Cell Outer Segment; Sulfur Radioisotopes | 1992 |
Protective effect of vinconate, a novel vinca alkaloid derivative, on glucose utilization and brain edema in a new rat model of middle cerebral artery occlusion.
Topics: Animals; Autoradiography; Brain; Brain Edema; Brain Ischemia; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Glucose; Male; Methionine; Protein Biosynthesis; Rats; Rats, Inbred Strains; Vinca Alkaloids | 1992 |
English setter model and juvenile ceroid-lipofuscinosis in man.
Topics: Animals; Ascorbic Acid; Bone Marrow Transplantation; Brain; Butylated Hydroxytoluene; Disease Models, Animal; Dogs; Electroencephalography; Female; Humans; Infant; Liver Transplantation; Male; Methionine; Neuronal Ceroid-Lipofuscinoses; Pigment Epithelium of Eye; Vitamin E | 1992 |
Maternal methionine supplementation promotes the remediation of axial defects in Axd mouse neural tube mutants.
Topics: Animals; Crosses, Genetic; Disease Models, Animal; Embryonic and Fetal Development; Female; Gene Expression; Methionine; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mutation; Neural Tube Defects; Pregnancy | 1992 |
Concentration of some proteinase inhibitors: alpha 1-antitrypsin and alpha 2-macroglobulin in rabbit blood serum in two models of experimental atherosclerosis.
Topics: alpha 1-Antitrypsin; alpha-Macroglobulins; Animals; Arteriosclerosis; Cholesterol, Dietary; Diet, Atherogenic; Disease Models, Animal; Male; Methionine; Protease Inhibitors; Rabbits; Reference Values | 1990 |
Anti-tumor effect of L-methionine-deprived total parenteral nutrition with 5-fluorouracil administration on Yoshida sarcoma-bearing rats.
Topics: Animals; Body Weight; Cause of Death; Combined Modality Therapy; Disease Models, Animal; Evaluation Studies as Topic; Fluorouracil; Male; Methionine; Neoplasm Metastasis; Parenteral Nutrition, Total; Rats; Sarcoma, Yoshida; Survival Rate | 1991 |
Usefulness of rapid production model for pancreatic carcinoma in male hamsters.
Topics: Animals; Carcinoma; Choline Deficiency; Cricetinae; Disease Models, Animal; Ethionine; Gallbladder; Male; Methionine; Nitrosamines; Pancreas; Pancreatic Neoplasms | 1990 |
Hepatic sulfur amino acid metabolism in rats with chronic renal failure.
Topics: Amino Acids, Sulfur; Animals; Anorexia; Creatinine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cystine; Disease Models, Animal; Growth Disorders; Kidney Failure, Chronic; Liver; Male; Methionine; Methionine Adenosyltransferase; Organ Size; Rats; Rats, Inbred Strains; Taurine; Urea; Uremia | 1990 |
Possible mechanism of immunosuppression by gramicidin S of S antigen-induced experimental autoimmune uveoretinitis.
Topics: Animals; Antigens; Arrestin; Autoimmune Diseases; Biological Transport; Cells, Cultured; Disease Models, Animal; Eye Proteins; Female; Gramicidin; Immunosuppressive Agents; Ionophores; Lymphocyte Activation; Lymphocytes; Methionine; Potassium; Rats; Rats, Inbred Lew; Sodium; Thymidine; Uveitis, Posterior | 1989 |
Effects of intraluminal hydrostatic pressure on L-methionine absorption in the obstructed small intestine of the rat.
Topics: Animals; Disease Models, Animal; Evaluation Studies as Topic; Hematocrit; Hydrostatic Pressure; Ileal Diseases; Ileum; Intestinal Absorption; Intestinal Obstruction; Intestine, Small; Male; Methionine; Pressure; Radioisotopes; Rats; Rats, Inbred Strains; Regression Analysis; Selenium | 1986 |
[Liver and blood enzyme spectra of rats with model anthracosis based on feeding a diet with additional amounts of methionine and pyridoxine].
Topics: Animals; Anthracosilicosis; Dietary Fats; Disease Models, Animal; Drug Evaluation, Preclinical; Liver; Male; Methionine; Pyridoxine; Rats; Time Factors | 1985 |
Studies of animal models of "toxaemia" with respect of fibrinogen and platelet survival and selectivity of proteinuria.
Topics: Albumins; Alpha-Globulins; Animals; Blood Coagulation; Blood Platelets; Cell Survival; Desoxycorticosterone; Disease Models, Animal; Disseminated Intravascular Coagulation; Female; Fibrinogen; Half-Life; Hypertension; Kidney Cortex Necrosis; Kidney Glomerulus; Methionine; Pre-Eclampsia; Pregnancy; Proteinuria; Rabbits; Radioisotopes; Rats; Selenium; Time Factors; Vasoconstrictor Agents | 1973 |
Animal model: fatty liver and cirrhosis in lipotrope-deficient male rats.
Topics: Animals; Choline Deficiency; Deficiency Diseases; Diet; Disease Models, Animal; Fatty Liver; Humans; Lipotropic Agents; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Rats; Vitamin B 12 Deficiency | 1973 |
Production rate and removal of rod outer segment material in vitamin A deficiency.
Topics: Animals; Autoradiography; Diagnosis, Differential; Diet; Disease Models, Animal; Electroretinography; Epithelium; Eye Proteins; Methionine; Phagocytosis; Photoreceptor Cells; Rats; Retina; Retinal Diseases; Retinitis Pigmentosa; Time Factors; Tritium; Vitamin A Deficiency | 1974 |
Plasma amino acids in experimental acute hepatic failure and their relationship to brain tryptophan.
Topics: Acute Disease; Alanine; Amino Acids; Animals; Brain Chemistry; Disease Models, Animal; Glycine; Hepatic Encephalopathy; Liver Diseases; Methionine; Swine; Tryptophan | 1974 |