methionine has been researched along with Choline Deficiency in 479 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 104 (21.71) | 18.7374 |
| 1990's | 39 (8.14) | 18.2507 |
| 2000's | 89 (18.58) | 29.6817 |
| 2010's | 197 (41.13) | 24.3611 |
| 2020's | 50 (10.44) | 2.80 |
| Authors | Studies |
|---|---|
| Ballentine, SJ; Brunt, EM; Davidson, NO; Molitor, EA; Newberry, EP; Soleymanjahi, S; Xie, Y | 1 |
| Guo, X; Han, J; Kawai, D; Koyama, T; Motoo, Y; Satoh, T; Yamada, S; Yamaguchi, R; Zhang, J; Zhou, X | 1 |
| Ahmeda, AF; Al Zarzour, RH; Alsalahi, A; Alshawsh, MA; Alshehade, SA; Mahmoud, AM; Saghir, SAM | 1 |
| Colares, JR; da Silva, JB; Hartmann, RM; Marroni, CA; Marroni, NP; Miguel, FM; Picada, JN; Schemitt, EG | 1 |
| Guo, Q; Ji, L; Kai, G; Lu, B; Miao, H; Ouyang, H; Wei, M | 1 |
| Alpini, G; Francis, H; Glaser, S; Guo, X; Li, H; Li, Q; Lu, B; Wang, F; Wu, C; Xie, L; Zhu, B | 1 |
| Gong, J; Liu, L; Liu, S; Liu, X; Tao, Y; Wang, Y; Wei, W; Zhao, X | 1 |
| Aljobaily, N; Cone, B; Han, Y; Joly, R; Krutsinger, K; Menlove, B; Suppes, A; Viereckl, MJ | 1 |
| Bian, C; Guo, X; Liang, Q; Lu, Z; Wang, H; Zhao, X; Zhen, Q; Zheng, Y | 1 |
| Chen, R; Du, H; Li, F; Lin, L; Luo, X; Ruan, C; Wu, S; Wu, Y; Zhang, X | 1 |
| Abe, A; Miyajima, K; Nakae, D; Nakane, S; Suzuki-Kemuriyama, N; Yuki, M | 1 |
| Choi, H; Choi, J; Chung, J | 1 |
| Chen, Y; Wang, J; Zhai, T | 1 |
| Arista Romeu, EJ; Campos-Espinosa, A; de la Rosa Vázquez, JM; Escobedo, G; Fabila Bustos, DA; Guzmán, C; Moreno-González, J; Romero-Bello, II; Stolik, S; Valor, A | 1 |
| Buechler, C; Feder, S; Haberl, EM; Krautbauer, S; Liebisch, G; Pohl, R; Rein-Fischboeck, L | 1 |
| Codella, R; Luzi, L; Mollica, G; Montesano, A; Senesi, P; Terruzzi, I; Vacante, F | 1 |
| Kim, B; Kim, JW; Lim, CW; Qi, J; Zhou, Z | 1 |
| Choi, SJ; Kim, B; Kim, JW; Lee, K; Lee, SH; Lim, CW; Park, S; Yun, H; Zhou, Z | 1 |
| Kim, SJ; Kwon, OS; Lee, DE; Lee, HS; Lee, SJ | 1 |
| Elmér, E; Gallay, P; Gregory, M; Grönberg, A; Hansson, MJ; Kuo, J; Longato, L; Massoumi, R; Mazza, G; Moss, S; Pinzani, M; Rombouts, K; Simón Serrano, S | 1 |
| Chen, Y; Fan, Y; Sun, R; Tian, Z; Wei, H; Zhang, W | 1 |
| Fu, R; He, Q; Jiang, R; Liu, Y; Lu, Y; Sun, B; Sun, Q; Tian, W; Wang, J; Xu, X; Yu, H; Zhang, Z | 1 |
| Gong, X; Hu, J; Kuang, G; Liu, J; Wan, J; Wu, S; Yin, X; Yuan, Y; Zhang, L; Zhang, X; Zhou, Q | 1 |
| Jiang, M; Li, HK; Li, LY; ShangGuan, T; Sun, WW; Yang, P; Zhang, ZH; Zhu, P | 1 |
| Guan, KL; Huang, X; Li, X; Li, Y; Liu, J; Sun, T; Wang, TX; Xiong, Y; Yuan, HX; Zang, S | 1 |
| Cai, K; Jiang, B; Li, X; Sheng, L; Song, Y; Wu, W | 1 |
| Alén, R; Barbas, C; Carrascosa, JM; García-Martínez, I; García-Rodríquez, JJ; Gribble, FM; Guijarro, LG; Lu, VB; Menchén, L; Puerto, M; Reimann, F; Rubio, C; Ruperez, J; Saiz, J; Sanmartín-Salinas, P; Toledo-Lobo, MV; Valverde, ÁM | 1 |
| Arao, Y; Hayatsu, M; Kamimura, K; Kawai, H; Kobayashi, T; Nakano, O; Terai, S; Ushiki, T | 1 |
| Jiang, Q; Li, G; Liu, B; Xu, K; Zhang, J | 1 |
| da Silva, RP; Eudy, BJ; Fernandez, G; Lai, J; Mathews, CE; McDermott, CE | 1 |
| Che, Y; Li, Y; Shi, X; Shi, Y; Si, R; Zhang, Y; Zhong, X | 1 |
| Hojo, N; Kanji, H; Kanzaki, K; Kawakami, T; Kawakami, Y; Kimura, Y; Mori, Y; Otsuki, A; Suzuki-Yamamoto, T; Takahashi, Y; Tanaka, R; Tsukayama, I | 1 |
| Cai, Z; Deng, L; Hu, L; Li, Z; Ren, Q; Wang, B; Wang, G; Zhou, Z | 1 |
| Balint-Lahat, N; Ben-Ari, Z; Brzezinski, RY; Finchelman, JM; Grossman, E; Hoffer, O; Leor, J; Levin-Kotler, L; Lewis, N; Naftali-Shani, N; Ovadia-Blechman, Z; Rabin, N; Safran, M; Sternfeld, A; Tepper-Shaihov, O; Unis, R; Zimmer, Y | 1 |
| Cardini, B; Fodor, M; Hautz, T; Hermann, M; Maglione, M; Margreiter, C; Mellitzer, V; Oberhuber, R; Öfner, D; Resch, T; Schneeberger, S; Schwelberger, H; Tilg, H; Troppmair, J; Weißenbacher, A; Wieser, V; Zelger, B | 1 |
| Hata, K; Hiwatashi, K; Naya, Y; Ogihara, K; Sasaki, A; Takahashi, J; Toshima, G | 1 |
| Buechler, C; Haberl, EM; Höring, M; Krautbauer, S; Liebisch, G; Pohl, R; Rein-Fischboeck, L | 1 |
| Berardo, C; Di Pasqua, LG; Ferrigno, A; Palladini, G; Perlini, S; Rizzo, V; Vairetti, M | 1 |
| Abe, A; Miyajima, K; Nakae, D; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M | 1 |
| Fierro, R; González-Márquez, H; Guéant, JL; Guéant-Rodríguez, RM; Marchal, A; Sámano-Hernández, L | 1 |
| Gu, H; Jia, K; Liu, P; Pan, M; Shen, Z; Sun, C; Yang, K | 1 |
| Ceacero-Heras, D; Córdova, S; de Medina, FS; Gámez-Belmonte, R; Hernández-Chirlaque, C; Martínez-Augustin, O; Tena-Garitaonaindia, M | 1 |
| Arrese, M; Cabrera, D; Hernández, A; Jara, E; Kalergis, AM; Muñoz-Durango, N | 1 |
| Baek, J; Basavarajappa, L; Hoyt, K; Parker, KJ; Reddy, S; Rijal, G; Song, J; Tai, H | 1 |
| Chen, Y; Cheng, Y; Ding, W; Fan, J; Jiang, D; Lin, S; Pan, J; Zhang, J | 1 |
| Choi, SE; Han, SJ; Heo, YJ; Jeon, JY; Kang, Y; Kim, DJ; Kim, HJ; Lee, KW; Lee, N | 1 |
| Awwad, HM; Geisel, J; Happ, DF; MacPherson, CW; Obeid, R; Tillmann, S; Tompkins, TA; Treccani, G; Ueland, PM; Wegener, G | 1 |
| He, J; Huang, C; Huang, H; Jing, X; Li, Y; Liu, Q; Tang, Q; Wu, T; Xia, Y; Xiao, J; Yan, J; Zhang, G; Zhang, J; Zhang, Z; Zhao, Y; Zhou, J | 1 |
| Ji, G; Li, C; Li, M; Shu, X; Zhang, L; Zhou, W | 1 |
| Bai, W; Feng, W; Han, L; Jiang, X; Li, X; Li, Z; Nie, H; Qin, W; Qin, Y | 1 |
| Chen, J; Gu, X; Luo, H; Su, C; Tang, J; Xiao, L; Xiong, F; Zha, L; Zhao, Y; Zheng, Z | 1 |
| Berardo, C; Cagna, M; Croce, AC; Di Pasqua, LG; Ferrigno, A; Mannucci, B; Milanesi, G; Vairetti, M | 1 |
| Cortopassi, G; Hui, CK; Jiang, JX; Montgomery, C; Tomilov, A; Török, NJ | 1 |
| Abe, A; Miyajima, K; Nakae, D; Nakane, S; Ogawa, S; Sano, R; Suzuki-Kemuriyama, N; Uno, K; Watanabe, A; Yuki, M | 1 |
| Abe, M; Akiba, J; Hisamoto, T; Ikezono, Y; Iwamoto, H; Koga, H; Matsui, T; Nakamura, K; Nakamura, T; Torimura, T; Wada, F; Yamagishi, SI; Yoshida, T | 1 |
| Alfaro, M; Chintapalli, SV; Kang, P; Shankar, K; Thakali, KM; Wankhade, UD; Zhong, Y | 1 |
| Bok, R; Carroll, V; Di Gialleonardo, V; Keshari, KR; Ohliger, MA; Sai, V; Taylor, A; VanCriekinge, M; Von Morze, C; Wang, ZJ; Wilson, DM | 1 |
| Badiali, S; Baselli, GA; Bassani, GA; Dongiovanni, P; Facciotti, F; Fargion, S; Gatti, S; Maggioni, M; Meroni, M; Pietrelli, A; Rametta, R; Trunzo, V; Valenti, L | 1 |
| Chen, Y; Cho, GJ; Chung, HT; Joe, Y; Kim, HJ; Kim, J; Kim, SK; Kim, UH; Park, J; Park, SU; Ryter, SW; Ryu, J; Surh, YJ | 1 |
| Hara, M; Ichimura, M; Kikuchi, K; Matsumoto, K; Miyakawa, H; Moritoki, Y; Omagari, K; Tsunashima, H; Tsuneyama, K; Yasuda, I | 1 |
| Allen, TL; Febbraio, MA; Henstridge, DC; Kammoun, HL; Kraakman, MJ; Peijs, L; Rose-John, S | 1 |
| Aoyama, T; Fang, ZZ; Fujimori, N; Golla, S; Gonzalez, FJ; Hu, X; Krausz, KW; Lu, Y; Takahashi, S; Tanaka, N | 1 |
| Barney, J; Hamad, OM; Hennig, B; Hoffman, JB; Morris, AJ; Petriello, MC; Thompson, B; Wahlang, B; Wang, C | 1 |
| Bedossa, P; Geys, L; Lijnen, HR; Roose, E; Scroyen, I; Vanhoorelbeke, K | 1 |
| Alpini, G; Demieville, J; Francis, H; Hargrove, L; Kennedy, L; Stephenson, K; Thomson, J | 1 |
| Cherrington, NJ; Li, H; Toth, E | 1 |
| Deng, X; Li, G; Liu, B; Xin, S; Xu, K; Zhang, H; Zhang, J; Zhang, N | 1 |
| Kang, BH; Lee, WK; Min, BH; Park, JS; Shim, YJ | 1 |
| Beretta, L; Fallon, M; Gjuka, D; Harrison, SA; Ioannou, GN; Shen, H; Song, X; Stevenson, HL; Wang, J; Yoo, SY; Yoo, W | 1 |
| Buechler, C; Feder, S; Haberl, EM; Krautbauer, S; Liebisch, G; Pohl, R; Rein-Fischboeck, L; Schmid, V | 1 |
| Alshammari, GM; Balakrishnan, A; Chinnasamy, T | 1 |
| Buechler, C; Feder, S; Haberl, EM; Pohl, R; Rein-Fischboeck, L; Sinal, CJ | 1 |
| Han, DH; Jo, YS; Kim, KH; Kim, SH; Lee, MS; Lee, YH | 1 |
| Cho, T; Mak, A; Uetrecht, J | 1 |
| Cho, PJ; Jeon, TW; Jeong, TC; Jo, JJ; Ki, SH; Kim, KM; Kwon, OK; Lee, S; Lee, TH; Na, AY; Shrestha, R | 1 |
| Chen, X; Fang, M; Kong, M; Xu, H; Xu, Y | 1 |
| Bian, XY; Fang, DQ; Jiang, XW; Li, LJ; Li, YT; Peng, CG; Shi, D; Wang, Q; Wu, JJ; Wu, WR; Xia, PC; Yang, LY; Ye, JZ; Ye, WC | 1 |
| Hong, W; Li, M; Liu, L; Ren, H; Shi, X; Wang, J; Xu, H; Xu, Y | 1 |
| Kang, BS; Kwon, OS; Lee, DE; Lee, DS; Lee, HS; Lee, SJ; Nam, MJ; Park, JW | 1 |
| Lee, S; Nam, KH; Ryu, DY; Seong, JK | 1 |
| Bae, UJ; Chae, SW; Ham, H; Jung, SJ; Park, BH; Park, EO; Park, J; Park, YJ; Yu, KW | 1 |
| Ao, KJ; Chen, LL; Ding, P; Li, J; Ma, Q; Tian, YY; Zhang, YH | 1 |
| Inaba, Y; Inoue, H; Kimura, K; Matsukawa, T; Matsumoto, M; Watanabe, H | 1 |
| Bao, L; Chen, Z; Ding, G; Guo, M; Guo, W; Liu, F; Zhan, Y; Zhang, M; Zhao, Y; Zheng, N | 1 |
| Khan, FU; Li, HX; Pan, WS; Qi-Li, FR; Qian, C; Xu, X; Zhang, L | 1 |
| Li, HX; Pan, WS; Qi-Li, FR; Qian, C; Ullah Khan, F; Xu, X; Zhang, L | 1 |
| Bennek, E; Candels, LS; Elfers, C; Gassler, N; Heymann, F; Kilic, K; Mohs, A; Penders, J; Schneider, KM; Schneider, LB; Trautwein, C | 1 |
| Borozan, S; Dragutinovic, V; Gopcevic, K; Isakovic, A; Jorgacevic, B; Labudovic-Borovic, M; Milenkovic, M; Mladenovic, D; Radosavljevic, T; Tosic, J; Trajkovic, V; Veskovic, M; Vucevic, D | 1 |
| Chamulitrat, W; Cheng, Y; Gan-Schreier, H; Ganzha, A; Liebisch, G; Otto, AC; Staffer, S; Tuma-Kellner, S; Zhu, X | 1 |
| Hamaguchi, T; Horibe, S; Kawauchi, S; Mizuno, S; Rikitake, Y; Sasaki, N; Tanahashi, T | 1 |
| Cherrington, NJ; Hardwick, RN; Lake, AD; Leamon, CP; Low, PS | 1 |
| Huang, YH; Kuo, HC; Wang, FS; Yang, YL | 1 |
| Hahn, KR; Hwang, IK; Jung, HY; Kim, JW; Seong, JK; Yoo, DY; Yoon, YS | 1 |
| Abu Ahmad, N; Arning, E; Bottiglieri, T; Raizman, M; Tirosh, O; Troen, AM; Wasek, B; Weizmann, N | 1 |
| Bona, S; Di Naso, FC; Dias, AS; Marroni, CA; Marroni, NP; Moreira, AJ; Picada, JN; Pires, TR; Rodrigues, G; Schemitt, E | 1 |
| Breitkopf-Heinlein, K; Ding, H; Dong, P; Dooley, S; Jiang, Q; Li, Q; Liu, B; Weng, H; Xu, K | 1 |
| Bae, GS; Choi, SB; Hong, SH; Jo, IJ; Kim, JJ; Kim, TH; Kim, YC; Koo, BS; Lee, DS; Park, KC; Park, SJ; Shin, YK; Song, HJ | 1 |
| He, J; Hu, B; Huang, M; Kelley, EE; Lu, P; Shi, X; Weidert, ER; Xie, W; Xu, M | 1 |
| Berneman, Z; Boeykens, N; De Greef, K; Ponsaerts, P; Van der Linden, A; Ysebaert, D | 1 |
| Choi, MK; Han, JM; Kim, HG; Lee, HW; Lee, JS; Park, HJ; Son, CG | 1 |
| Baghdasaryan, A; Claudel, T; Das, SK; Halilbasic, E; Hoefler, G; Jha, P; Lass, A; Mueller, M; Trauner, M; Zechner, R; Zimmermann, R | 1 |
| Asahara, T; Asano, T; Chonan, O; Fujishiro, M; Fukushima, T; Iwashita, M; Kamata, H; Kushiyama, A; Matsunaga, Y; Nakatsu, Y; Nishimura, F; Okubo, H; Sakoda, H; Yoshida, Y | 1 |
| Cheng, L; Dai, RW; Luo, ZL; Ren, JD; Tang, LJ; Tian, FZ; Wang, T; Xiang, K | 1 |
| Aleksić, V; Cerović, I; Jorgačević, B; Mladenović, D; Ninković, M; Prokić, V; Radosavljević, T; Stanković, M; Stanković, MN; Vučević, D; Vukićević, RJ | 1 |
| Fujino, M; Kawai, K; Li, XK; Luo, XY; Nakae, S; Sugiyama, T; Takahara, T; Tsukada, K; Tsuneyama, K; Zhong, L | 1 |
| Aibara, D; Gonzalez, FJ; Matsuo, K; Matsusue, K; Takiguchi, S; Yamano, S | 1 |
| Blomme, E; Cherrington, NJ; Clarke, JD; Lake, AD; Maher, J; Sharapova, T | 1 |
| Ezaki, T; Itagaki, H; Morikawa, S; Ogawa, K; Shimizu, K | 1 |
| Angus, PW; Forbes, JM; Goodwin, M; Herath, CB; Jia, Z; Leung, C; Mak, KY; Watt, MJ | 1 |
| Hatano, E; Koyama, Y; Nakamura, K; Seo, S; Takemoto, K; Tanabe, K; Taura, K; Toriguchi, K; Uemoto, S | 1 |
| Canet, MJ; Cherrington, NJ; Clarke, JD; Dzierlenga, AL; Hardwick, RN; Lake, AD | 1 |
| Ahn, JH; Baik, SH; Choi, DS; Choi, KM; Kim, HJ; Kim, NH; Kim, SG; Kim, TW; Noh, KH; Seo, JA; Yoo, W; Yu, JH | 1 |
| Croniger, CM; DeSantis, DA; Hise, AG; Ko, CW; Liu, X; Liu, Y; Nunez, G | 1 |
| Burrington, CM; Chowdhry, S; Davenport, SK; Greene, MW; Horsman, MJ; Johnson, AK; Lynch, DT; Sparks, JD; Tirrell, PC; Zhang, J | 1 |
| Delogu, W; Laffi, G; Maggiora, M; Marra, F; Maurino, V; Milani, S; Navari, N; Novo, E; Parola, M; Provenzano, A; Vizzutti, F | 1 |
| Csak, T; Dolganiuc, A; Ganz, M; Kodys, K; Kurt-Jones, EA; Lippai, D; Park, JK; Petrasek, J; Pillai, A; Szabo, G | 1 |
| Albano, E; Bena, S; Bozzola, C; Bugianesi, E; Jindal, A; Kusters, D; Locatelli, I; McArthur, S; Parola, M; Paternostro, C; Perretti, M; Reutelingsperger, C; Sutti, S; Vacchiano, M | 1 |
| Chen, T; Hong, YM; Qiu, LX; Su, WJ; Zhong, FJ; Zhuang, LL | 1 |
| Chen, S; Gu, J; Ji, L; Liu, X; Peng, X; Shen, X; Wu, W; Xue, R; Zhang, S | 1 |
| da Silva, LE; Deminice, R; Jordao, AA; Rosa, FT | 1 |
| Choi, YK; Jang, BK; Jung, GS; Jung, YA; Kim, HS; Kim, JG; Kim, MK; Lee, IK; Park, KG; Seo, HY | 1 |
| Bergheim, I; Boekschoten, MV; Gassler, N; Hatting, M; Kroy, DC; Müller, M; Ramadori, P; Schumacher, F; Streetz, KL; Trautwein, C | 1 |
| Cho, EJ; Jang, ES; Kim, CY; Kim, YJ; Kwak, MS; Lee, HS; Lee, JH; Yoon, JH; Yu, SJ | 1 |
| Appelqvist, H; Astudillo, AM; Balsinde, J; Baulies, A; Bergheim, I; Czaja, MJ; Elena, M; Fernandez, A; Fernandez-Checa, JC; Fucho, R; Garcia-Rovés, P; García-Ruiz, C; Kaplowitz, N; Lotersztajn, S; Martínez, L; Paton, AW; Paton, JC; Ribas, V; Tarrats, N; Torres, S; Trautwein, C | 1 |
| Inoue, A; Kishi, K; Koh, M; Miyazaki, H; Takitani, K; Tamai, H | 1 |
| Chui, PC; Cunniff, JC; Fisher, FM; Flier, JS; Kharitonenkov, A; Lundasen, T; Maratos-Flier, E; Nasser, IA; Popov, Y; Schuppan, D | 1 |
| de Luka, S; Jorgacevic, B; Mladenovic, D; Radosavljevic, T; Stevanovic, I; Veskovic, M | 1 |
| Li, Y; Ouyang, G; Wu, S; Xiong, S | 1 |
| Guo, H; Jiang, X; Ling, W; Shen, T; Sun, X; Tang, X; Xia, M | 1 |
| Bohle, RM; Gemperlein, K; Haybaeck, J; Kessler, SM; Kiemer, AK; Müller, R; Simon, Y | 1 |
| Chang, CJ; Liou, SS; Liu, IM; Tzeng, TF | 1 |
| Fujita, K; Fujiwara, S; Himoto, T; Hirashima, M; Iwama, H; Kato, K; Katsura, A; Kobara, H; Maeda, E; Masaki, T; Miyoshi, H; Mori, H; Morishita, A; Niki, T; Nomura, T; Ono, M; Sakamoto, T; Tani, J; Tatsuta, M; Toyota, Y; Yoneyama, H | 1 |
| Kobayashi, Y; Nohara, K; Okamura, K; Sano, T; Takumi, S; Yanagisawa, H | 1 |
| Ishii, D; Kawai, K; Mashimo, Y; Matsuda, S; Matsuzawa, D; Shimizu, E; Sutoh, C; Tomizawa, H | 1 |
| Gonzalez, FJ; Krausz, KW; Patterson, AD; Smith, PB; Takahashi, S; Tanaka, N; Zhang, Y | 1 |
| Akimoto, T; Alam, MM; Goto, M; Haseba, T; Kitamura, H; Motohashi, H; Ota, N; Shimizu, A; Takano-Yamamoto, T; Yamamoto, M | 1 |
| Iqbal, W; Kang, JH; Kwon, OS; Lee, SJ | 1 |
| Aube, C; Bazeries, P; Boursier, J; Chaigneau, J; Ducluzeau, PH; Fizanne, L; Flamment, M; Leiber, LM; Michalak, S; Moal, V; Roullier, V; Roux, J | 1 |
| Chen, Y; Deng, Y; Ding, Y; Qian, K; Sun, X | 1 |
| Han, F; Huang, Z; Liu, Y; Lu, J; Sugiyama, K; Sun, L; Wang, Q | 1 |
| Brandenburg, LO; Drescher, H; Erschfeld, S; Giebeler, A; Grossarth, V; Heinrichs, D; Kroy, D; Soehnlein, O; Streetz, K; Trautwein, C; Wertenbruch, S | 1 |
| Asano, T; Fujishiro, M; Fukushima, T; Kamata, H; Kanaoka, R; Katasako, A; Kushiyama, A; Matsunaga, Y; Mori, K; Nakatsu, Y; Sakoda, H; Seno, Y; Yamamotoya, T | 1 |
| Almeida Pereira, T; Bohnic, B; Boursier, J; de Almeida, TP; Diehl, AM; Guy, CD; Machado, MV; Michelotti, GA; Xie, G | 1 |
| Grenert, JP; Maher, JJ; Pickens, MK; Pierce, AA; Siao, K | 1 |
| Bohnic, B; Boursier, J; de Almeida, TP; Diehl, AM; Guy, CD; Machado, MV; Michelotti, GA; Xie, G | 1 |
| Abdel-Latif, HA; Ali, MH; Messiha, BA | 1 |
| Ben Ya'acov, A; Ilan, Y; Khoury, T; Shabat, Y; Snir, R; Zolotarovya, L | 1 |
| Asano, T; Fujishiro, M; Fukushima, T; Iwai, K; Iwashita, M; Kamata, H; Kushiyama, A; Matsunaga, Y; Nakatsu, Y; Okubo, H; Sakoda, H; Takahashi, S; Tokunaga, F; Tsuchiya, Y; Yamamotoya, T | 1 |
| Afonso, MB; Borralho, P; Caridade, M; Carvalho, T; Castro, RE; Cortez-Pinto, H; Rodrigues, CM; Rodrigues, PM | 1 |
| Albano, E; Bozzola, C; Bruzzì, S; Jindal, A; Locatelli, I; Sutti, S; Vacchiano, M | 1 |
| Chu, ES; Du, J; Go, MY; Han, J; Li, X; Man, K; Sung, JJ; Yu, J; Zhang, X | 1 |
| Choi, HJ; Jang, S; Jo, W; Kim, JK; Kim, KW; Lee, HJ; Ryu, JE; Son, WC; Woo, DC; Yu, ES | 1 |
| Deng, Y; Ji, G; Jiang, Z; Li, X; Wang, Y | 1 |
| Cheng, YJ; Liou, SS; Liu, IM; Tzeng, TF; Tzeng, YC | 1 |
| Chen, J; Fan, X; Gao, X; Zhou, L | 1 |
| Asahara, T; Asano, T; Chonan, O; Encinas, J; Fujishiro, M; Fukushima, T; Iizuka, M; Inaba, T; Kamata, H; Katagiri, H; Kushiyama, A; Nagamachi, A; Nakatsu, Y; Nishimura, F; Okubo, H; Sakoda, H; Taki, N; Yoshida, Y | 1 |
| Furuichi, Y; Kobayashi, Y; Kojima, M; Moriyasu, F; Nakamura, I; Ogawa, S; Oshiro, H; Sano, T; Sugimoto, K; Yoshida, K | 1 |
| Ahn, YS; Cha, SW; Han, SH; Kang, OH; Kim, SB; Kong, R; Kwon, DY; Lee, YS; Seo, YS | 1 |
| Cho, EH; Choi, DH; Lee, EH; Lee, S; Li, YH; Seo, SR | 1 |
| Harimoto, N; Ikegami, T; Itoh, S; Kimura, K; Maehara, Y; Okano, S; Shirabe, K; Takeishi, K; Uchiyama, H; Yoshizumi, T | 1 |
| Aljazi, MB; Atshaves, BP; Brock, JR; Fader, KA; Jones, AD; Lydic, TA; Najt, CP; Olenic, SD; Senthivinayagam, S | 1 |
| Cerović, IB; Ješić Vukićević, R; Jorgačević, BZ; Mladenović, DR; Radosavljević, TS; Stevanović, I; Vesković, MN; Vučević, DB | 1 |
| Choi, KC; Choi, SJ; Kim, B; Kim, JW; Lee, K; Lee, SH; Lim, CW; Park, S; Yun, H | 1 |
| Han, SI; Isaka, M; Iwasaki, H; Kikuchi, T; Kobayashi, K; Matsuzaka, T; Mizuno, S; Nakagawa, Y; Ohno, H; Oikawa, F; Osaki, Y; Satoh, A; Shimano, H; Sone, H; Suzuki, H; Takahashi, S; Takei, K; Yagishita, Y; Yahagi, N; Yamada, N; Yatoh, S | 1 |
| Hou, C; Huang, Y; Li, W; Li, X; Ma, F; Zhang, A; Zhang, L; Zhu, Y | 1 |
| Cho, HJ; Cho, SJ; Chong, S; Chung, SJ; Kang, IM; Kim, DD; Kim, SB; Lee, JI; Yoon, IS | 1 |
| Agra, N; Boscá, L; Brea Contreras, R; Carnovale, CE; Casado, M; Domínguez-Moreno, M; Francés, DE; García-Monzón, C; Martín-Sanz, P; Mayoral, R; Motiño, O; Valdecantos, MP; Valverde, ÁM; Vargas-Castrillón, J | 1 |
| Jung, YS; Kim, JD; Kim, SH; Kim, SN; Kwon, HJ; Lee, YH; Oh, JY | 1 |
| Bertolo, RF; Brunton, JA; McBreairty, LE; Randell, EW; Robinson, JL | 1 |
| Maher, JJ | 1 |
| Kang, BS; Kang, JH; Kwon, OS; Lee, DE; Lee, DS; Lee, HS; Lee, SJ; Nam, MJ; Park, JW | 1 |
| Duan, XP; Huo, XK; Liu, KX; Liu, ZH; Meng, Q; Peng, JY; Sun, HJ; Sun, PY; Wang, CY | 1 |
| Kim, HS; Kim, M; Nho, CW; Randy, A; Yoo, G | 1 |
| Asagiri, M; Hatano, E; Ikeno, Y; Iwaisako, K; Kasai, Y; Koyama, Y; Nishio, T; Okuda, Y; Okuno, M; Sakurai, T; Seo, S; Tanabe, K; Taura, K; Uemoto, S; Yamamoto, G; Yoshino, K | 1 |
| Bridges, D; Miller, DD; Narayanan, R; Ponnusamy, S; Thiyagarajan, T; Tran, QT | 1 |
| Ahmed, RF; Amin, MM; Saleh, DO | 1 |
| Clahsen, T; Drescher, HK; Hornef, M; Kroy, DC; Noels, H; Sahin, H; Schippers, A; Streetz, KL; Trautwein, C; Wagner, N | 1 |
| Bian, Y; Fang, M; Li, L; Shao, J; Xu, H; Xu, Y; Yang, L | 1 |
| An, W; Lv, F; Miao, D; Wang, Y; Wu, J | 1 |
| Bell-Anderson, KS; Farrell, GC; Larter, CZ; Williams, J; Yeh, MM | 1 |
| Akahori, H; Ando, H; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa-Nagata, N; Misu, H; Nabemoto, S; Nakanuma, Y; Ota, T; Takamura, T; Uno, M; Zen, Y | 1 |
| Akao, M; Hibi, T; Irie, R; Miyashita, K; Mizutani, A; Noguchi, M; Ohkura, T; Oike, Y; Sumimoto, H; Suzuki, T; Tabata, M; Taguchi, T; Takayanagi, A; Tamiya, G; Teratani, T; Tomita, K; Yokoyama, H | 1 |
| Larter, CZ; Yeh, MM | 1 |
| Hay, SM; Maloney, CA; Rees, WD | 1 |
| Lin, CC; Liu, WH; Yin, MC | 1 |
| Gyamfi, MA; He, L; Klaassen, CD; Tanaka, Y; Wan, YJ | 1 |
| Dolganiuc, A; Ellis, M; Kodys, K; Mandrekar, P; Petrasek, J; Szabo, G; Velayudham, A | 1 |
| Berk, M; Feldstein, AE; Li, ZZ; McIntyre, TM | 1 |
| Aeed, H; Avni, Y; Ilan, Y; Shahmurov, M; Shalev, T; Shirin, H; Sorin, V; Stavinski, S | 1 |
| Abarca-Quinones, J; Brichard, S; Da Silva Morais, A; Guigas, B; Hue, L; Lebrun, V; Leclercq, IA; Viollet, B | 1 |
| Morita, T; Ohuchi, S; Setoue, M; Sugiyama, K | 1 |
| Brooling, J; dela Pena, A; Farrell, GC; Francisco, R; Hou, JY; Larter, CZ; Osvath, SR; Sedger, LM; Teoh, N; Williams, J; Yeh, MM; Zhang, RH | 1 |
| Beysen, C; Grenert, JP; Maher, JJ; Ng, RK; Ogata, H; Pickens, MK; Turner, SM; Yan, JS | 1 |
| Kanayama, M; Kawai, K; Kudo, H; Mann, DA; Morita, S; Nakayama, Y; Oya, T; Sasahara, M; Sugiyama, T; Takahara, T; Yata, Y | 1 |
| Bagnyukova, TV; Beland, FA; James, SJ; Muskhelishvili, L; Pogribny, IP; Shpyleva, SI | 1 |
| Bagnyukova, TV; Beland, FA; Latendresse, JR; Melnyk, S; Montgomery, B; Pogribny, IP; Ross, SA; Rusyn, I; Tryndyak, VP | 1 |
| Harnish, DC; Liu, Q; Wang, J; Zhang, S | 1 |
| Akin, H; Atug, O; Avsar, E; Celikel, C; Eren, F; Imeryuz, N; Ozdogan, O; Ozguner, F; Tahan, G; Tahan, V; Tarcin, O; Tozun, N; Uzun, H | 1 |
| Miyazaki, H; Takitani, K; Tamai, H; Yoden, A | 1 |
| Catalano, D; Dolganiuc, A; Kodys, K; Mandrekar, P; Petrasek, J; Szabo, G; Velayudham, A | 1 |
| Abdelmalek, M; Choi, SS; Conde-Vancells, J; Diehl, AM; Fearing, CM; Guy, CD; Jung, Y; Karaca, GF; Omenetti, A; Pereira, TA; Syn, WK; Teaberry, V; Wang, J; Witek, RP; Yang, L | 1 |
| Cecchi, AO; Domenici, FA; Jordao, AA; Portari, GV; Vannucchi, H; Zanutto, ME; Zucoloto, S | 1 |
| Amini, R; Molaei, M; Nosrati, N; Yazdanparast, R | 1 |
| Agboola, KM; Charlton, P; Choi, SS; Diehl, AM; Guy, CD; Jung, Y; Karaca, FG; Omenetti, A; Pereira, TA; Pollard, J; Stone, WC; Syn, WK; Teaberry, V; Witek, RP | 1 |
| Elias, MS; Green, RM; Henkel, AS | 1 |
| Ahsan, MK; Hoshino, Y; Masutani, H; Nakamura, H; Oka, S; Okuyama, H; Yodoi, J | 1 |
| Arena, U; Caligiuri, A; Delogu, W; Galastri, S; Laffi, G; Marra, F; Milani, S; Novo, E; Parola, M; Pinzani, M; Provenzano, A; Vizzutti, F; Zamara, E | 1 |
| Hyodo, I; Ishige, K; Ishii, T; Nakahara, A; Okada, K; Shoda, J; Sugimoto, H; Taguchi, K; Ueda, T; Warabi, E; Yamamoto, M; Yanagawa, T | 1 |
| Apte, U; Behari, J; Cieply, B; Evans, R; Hauth, B; Krauland, L; Monga, SP; Otruba, W; Wu, T; Yeh, TH | 1 |
| Gentile, CL; Nivala, AM; Pagliassotti, MJ; Pfaffenbach, KT; Wang, D; Wei, Y | 1 |
| Chen, XR; Kwada, N; Mu, YP; Ogawa, T; Xi, XH | 1 |
| Chang, SI; Chen, TC; Hsiao, IT; Lin, KJ; Yeh, TS; Yen, TC | 1 |
| Chen, XR; Mu, YP; Xi, XH | 1 |
| EDER, HA; OLSON, RE; STARE, FJ | 1 |
| Klaassen, CD; Tanaka, Y; Yeager, RL; Zhang, YK | 1 |
| Fujii, H; Itoh, Y; Niimi, T; Nishimura, T; Okanoue, T; Yamaguchi, K; Yokomizo, C; Yoshikawa, T | 1 |
| Cheng, AS; Chu, ES; Lam, CN; Lee, CW; Sung, JJ; Wong, VW; Wu, CW; Yu, J | 1 |
| Beland, FA; Kosyk, O; Pogribny, IP; Ross, SR; Rusyn, I; Starlard-Davenport, A; Tryndyak, V | 1 |
| Galle, PR; Schattenberg, JM | 1 |
| Adegboyega, P; Allman, M; Brady, K; Gaskin, L; Pang, J; Pruitt, K; Rivera, CA | 1 |
| Adams, DH; Choi, SS; Diehl, AM; Fearing, CM; Guy, CD; Jung, Y; Karaca, GF; Omenetti, A; Oo, YH; Pereira, FE; Pereira, TA; Syn, WK; Teaberry, V; Witek, RP | 1 |
| Grenert, JP; Maher, JJ; Ogata, H; Pickens, MK; Soon, RK | 1 |
| Anstee, QM; Charlton, P; Concas, D; Goldin, RD; Kudo, H; Levene, A; Pollard, J; Thomas, HC; Thursz, MR | 1 |
| Hollenbeck, CB | 1 |
| Grenert, JP; Maher, JJ; Soon, RK; Yan, JS | 1 |
| Benedetti, A; Brenner, DA; De Minicis, S; Kluwe, J; Kodama, Y; Miyai, K; Osterreicher, CH; Paik, YH; Schwabe, RF; Seki, E; Torozzi, L | 1 |
| Guo, GL; Kassel, KM; Luyendyk, JP; Tawfik, O | 1 |
| Harada, T; Imada, K; Kajikawa, S; Kawashima, A; Mizuguchi, K; Shimizu, Y; Takeuchi, T | 1 |
| Fu, MM; Sun, R; Tian, ZG; Wei, HM | 1 |
| Song, Z; Wang, Z; Yao, T | 1 |
| Abdelmalek, MF; Adams, DH; Agboola, KM; Bhattacharya, SD; Chen, Y; Choi, SS; Diehl, AM; Guy, CD; Jung, Y; Karaca, GF; Kuo, PC; Liaskou, E; Malladi, P; Mi, Z; Michelotti, GA; Moylan, C; Omenetti, A; Oo, YH; Pereira, TA; Syn, WK; Teaberry, V; Whitington, PF; Zdanowicz, M | 1 |
| Baba, T; Kobayashi, Y; Matsumoto, M; Murai, H; Nishimura, N; Nohara, K; Sano, T; Suzuki, T; Tateishi, Y | 1 |
| Aghazadeh, S; Amini, R; Ghaffari, SH; Yazdanparast, R | 1 |
| Andrew, R; Aucott, RL; Iredale, JP; Livingstone, DE; Macfarlane, DP; Morton, NM; Nyirenda, MJ; Walker, BR; Zou, X | 1 |
| Beaven, SW; Bensinger, S; Hong, C; Tontonoz, P; Tsukamoto, H; Wang, J; Wroblewski, K | 1 |
| Horiguchi, N; Kakizaki, S; Mori, M; Takizawa, D; Tojima, H; Yamazaki, Y | 1 |
| Catalano, D; Csak, T; Dolganiuc, A; Hritz, I; Kurt-Jones, E; Levin, I; Lippai, D; Mandrekar, P; Petrasek, J; Szabo, G; Velayudham, A | 1 |
| Heger, M; Kloek, JJ; Marsman, HA; Nederveen, AJ; Nienhuis, SL; Stoker, J; Ten Kate, FJ; van Gulik, TM; van Werven, JR | 1 |
| Lu, SC; Mato, JM | 1 |
| Han, F; Kong, L; Kong, LB; Nan, YM; Wang, RQ; Wu, WJ; Yu, J; Zhao, SX | 1 |
| Fujii, H; Itoh, Y; Niimi, T; Nishimura, T; Okanoue, T; Umemura, A; Yamaguchi, K; Yokomizo, C; Yoshikawa, T | 1 |
| Iwamoto, J; Matsumoto, H; Sato, Y; Seki, A; Takeda, T; Yeh, JK | 1 |
| Bala, S; Csak, T; Dolganiuc, A; Kodys, K; Lippai, D; Nath, B; Petrasek, J; Szabo, G | 1 |
| Csak, T; Dolganiuc, A; Ganz, M; Kodys, K; Pespisa, J; Szabo, G | 1 |
| Elias, M; Gardikiotes, K; Gottstein, J; Green, RM; Rinella, ME; Siddiqui, MS | 1 |
| Heger, M; Kloek, JJ; Marsman, HA; Nienhuis, SL; ten Kate, FJ; van Gulik, TM | 1 |
| Breier, BH; Dziadek, MA; Ferguson, LR; Konycheva, G; Owens, JA; Patel, S; Ravelich, SR; Reddy, S; Smith, GC; Vickers, MH | 1 |
| Katsuya, T; Kiomy Osako, M; Koriyama, H; Kyutoku, M; Minobe, N; Miyake, T; Morishita, R; Moritani, T; Nakagami, F; Nakagami, H; Shimamura, M; Shimizu, H; Shimosato, T | 1 |
| Miyahara, T; Miyata, Y; Moriyasu, F | 1 |
| Cho, MS; Jang, JE; Jeon, BH; Koh, EH; Lee, KU; Leem, J; Park, HS; Park, IS; Woo, SH | 1 |
| Bonora-Centelles, A; Castell, JV; José Gómez-Lechón, M; López, S; Negro, A; Pareja, E; Teresa Donato, M; Tolosa, L | 1 |
| Cho, WK; Choi, HS; Hahm, JS; Jang, KS; Jeon, HJ; Jun, DW; Jun, JH; Kim, HJ; Kwon, HJ; Lee, HL; Lee, KN; Lee, MH; Lee, OY; Yoon, BC | 1 |
| Brückner, S; Christ, B; Pelz, S; Stock, P | 1 |
| Canet, MJ; Cherrington, NJ; Fisher, CD; Hardwick, RN; Street, SM | 1 |
| Kim, HS; Kim, JG; Kim, MK; Lee, IK; Lee, KU; Min, AK; Park, KG; Seo, HY | 1 |
| Bucchieri, F; Bugianesi, E; Galvano, F; Li Volti, G; Mangiameli, A; Marino Gammazza, A; Marino, A; Parola, M; Paternostro, C; Salamone, F; Tibullo, D | 1 |
| Cha, BS; Chae, MK; Kang, ES; Lee, BW; Lee, HC; Park, SG; Song, SO | 1 |
| Harada, N; Hashimoto, E; Horie, M; Ishii, T; Itoh, K; Okada, K; Shoda, J; Sugimoto, H; Taguchi, K; Tokushige, K; Ueda, T; Utsunomiya, H; Warabi, E; Yamamoto, M | 1 |
| Molaei, M; Rezazadeh, A; Yazdanparast, R | 1 |
| Berk, M; Dixon, LJ; Feldstein, AE; Papouchado, BG; Thapaliya, S | 1 |
| Kwada, N; Mu, YP; Ogawa, T | 1 |
| Anderson, KA; Dewey, AM; Green, RM; Henkel, AS; Olivares, S | 1 |
| Barbagallo, I; Cappello, F; Galvano, F; Li Volti, G; Mangiameli, A; Salamone, F | 1 |
| Ebinuma, H; Hatsuse, K; Hibi, T; Hokari, R; Irie, R; Kanai, T; Kurihara, C; Mataki, N; Minamino, T; Miura, S; Nishiyama, K; Okada, Y; Oshikawa, T; Saito, H; Shimamura, K; Shimizu, I; Sugiyama, K; Suzuki, T; Teratani, T; Tomita, K; Yamamoto, J; Yokoyama, H; Yoshida, Y | 1 |
| Conde de la Rosa, L; Fernandez, A; Fernandez-Checa, JC; Fucho, R; Garcia-Ruiz, C; Kaplowitz, N; Machida, K; Mansouri, A; Martinez-Chantar, ML; Matias, N; Mato, JM; Murphy, MP; Tsukamoto, H; von Montfort, C | 1 |
| Canet, MJ; Cherrington, NJ; Gandolfi, AJ; Hardwick, RN; Klimecki, WT; Kopplin, MJ; Lake, AD; Scheffer, GL | 1 |
| Battle, M; Doddapattar, P; Hoefler, G; Kratky, D; Levak-Frank, S; Obrowsky, S; Patankar, JV | 1 |
| Liu, Y; Liu, YQ; Mori, M; Morita, T; Sugiyama, K | 1 |
| Barakat, HA; Hamza, AH | 1 |
| González-Gallego, J; Marcolin, E; Marroni, N; San-Miguel, B; Tieppo, J; Tuñón, MJ; Vallejo, D | 1 |
| Bigaud, E; Corrales, FJ; He, B; O'Malley, BW; Prieto, J; Sánchez-Quiles, V; Santamaría, E; Segura, V | 1 |
| Carpentier, S; Danjoux, M; Garcia, V; Levade, T; Mas, E; Ségui, B | 1 |
| Davaatseren, M; Hur, HJ; Hwang, JT; Kim, HJ; Kim, MJ; Kim, MS; Kwon, DY; Park, JH; Sung, MJ; Yang, HJ | 1 |
| Carmeliet, P; Casteleyn, C; Colle, I; Coulon, S; Geerts, A; Heindryckx, F; Jonckx, B; Leclercq, I; Legry, V; Libbrecht, L; Olievier, K; Stassen, JM; Van Steenkiste, C; Van Vlierberghe, H | 1 |
| Hada, N; Ito, T; Katsume, A; Matsumoto, M; Sakamaki, Y; Shiga, T; Sudoh, M; Tanaka, C; Uno, A | 1 |
| Bassani, VL; Borghetti, GS; Forgiarini, LF; Marcolin, E; Marroni, NP; Picada, JN; Rodrigues, G; Tieppo, J | 1 |
| Kokkinakis, DM; Wick, JB; Zhou, QX | 1 |
| Aoyama, Y; Kanno, T; Kikuchi, H; Kurasaki, M; Nocianitri, KA; Sakakibara, S | 1 |
| Farrell, GC; Hall, P; Ip, E; Kirsch, R; Leclercq, I; Robertson, G | 1 |
| Alberto, JM; Antunes, L; Ayav, A; Braun, M; Bresler, L; Bronowicki, JP; Brunaud, L; Gérard, P; Guéant, JL; Namour, F | 1 |
| BEST, CH; LUCAS, CC; PATTERSON, JM; RIDOUT, JH | 1 |
| VOLGAREV, MN | 1 |
| Clark, S; Mitbander, VB; Sidransky, H | 1 |
| HUME, JW; MULFORD, DJ; RUSSELL, PJ | 1 |
| RADOMSKI, MW; WOOD, JD | 2 |
| Clarkson, V; Hall, Pde L; Jaffer, MA; Kirsch, R; Kirsch, RE; Marais, DA; Shephard, EG; Woodburne, VE | 1 |
| Green, RM; Rinella, ME | 1 |
| Kashireddy, PR; Rao, MS | 1 |
| SIMS, FH | 1 |
| Green, RM; Malladi, P; Melin-Aldana, H; Sahai, A; Whitington, PF | 1 |
| Green, RM; Malladi, P; Melin-Aldana, H; Pan, X; Paul, R; Sahai, A; Whitington, PF | 1 |
| Avsar, E; Imeryuz, N; Tahan, V; Tozun, N; Yavuz, D | 1 |
| Farrell, GC; Ito, Y; McCuskey, MK; McCuskey, RS; Perry, M; Robertson, GR | 1 |
| Green, RM; Koppe, SW; Malladi, P; Sahai, A; Whitington, PF | 1 |
| Davis, CD; Uthus, EO | 1 |
| dela Peña, A; Farrell, GC; Horsmans, Y; Leclercq, IA; Sempoux, C | 1 |
| Green, RM; Sundaram, SS; Whitington, PF | 1 |
| da Costa, KA; Fischer, LM; Gaffney, CE; Zeisel, SH | 1 |
| Ando, S; Chiyo, T; Han, JY; Hibi, T; Horie, Y; Ishii, H; Kaneko, T; Kato, S; Kitamura, N; Kumagai, N; Makino, S; Mizutani, A; Nagata, H; Ohkura, T; Ohsumi, K; Oike, Y; Saito, H; Shimoda, M; Tamiya, G; Toda, K; Tomita, K; Tomizawa, M | 1 |
| Dela Peña, A; Farrell, G; Field, J; George, J; Jones, B; Leclercq, I | 1 |
| Czaja, MJ; Lefkowitch, JH; Rigoli, RM; Schattenberg, JM; Scherer, PE; Singh, R; Wang, Y | 1 |
| Kohli, R; Malladi, P; Pan, X; Paul, R; Sahai, A; Whitington, PF | 1 |
| Dela Peña, A; Farrell, GC; Hall, P; Hou, JY; Ip, E; Kirsch, R; Leclercq, I; Pera, N; Sesha, J; Yu, J | 1 |
| Bai, S; Datta, J; Ghoshal, K; Huang, Y; Jacob, ST; Li, X; Pogribny, I; Pogribny, M; Young, D | 1 |
| Clarkson, V; de la M Hall, P; Kirsch, R; Marais, AD; Ryffel, B; Shephard, EG; Verdonk, RC | 1 |
| Hasegawa, H; Hashimoto, T; Ogawa, K; Shinohara, Y; Tagoku, K | 1 |
| Arnaboldi, L; Badger, TM; Gabrielli, B; Lee, GS; Maher, JJ; Ng, RK; Pitas, RE; Rizki, G; Turner, SM; Yan, J | 1 |
| Bai, S; Datta, J; Frankel, W; Ghoshal, K; Jacob, ST; Kutay, H; Motiwala, T; Pogribny, I | 1 |
| Horiguchi, N; Kakizaki, S; Mori, M; Negishi, M; Sato, K; Sohara, N; Takagi, H; Yamazaki, Y | 1 |
| Green, RM; Igolnikov, A; Lammert, F; Rangnekar, AS | 1 |
| Hall, Pde L; Kirsch, R; Marais, AD; Sijtsema, HP; Tlali, M | 1 |
| dela Peña, A; Farrell, GC; Leclercq, IA; Williams, J | 1 |
| Li, Z; Vance, DE | 1 |
| Alves, VA; Barbeiro, HV; Caldwell, SH; Carrilho, FJ; de Lima, VM; de Mello, ES; de Oliveira, CP; Sawada, LY; Soriano, FG | 1 |
| Chan, HL; Cheung, KF; Chu, ES; Farrell, GC; Hui, AY; Leung, WK; Sung, JJ; Yu, J | 1 |
| Bahcecioglu, IH; Duzgun, S; Gulcu, F; Koca, S; Ozercan, IH; Sahin, K; Ustundag, B | 1 |
| Friedman, JE; Janssen, RC; Jiang, H; Maclean, KN; Qadri, I; Rahman, SM; Schroeder-Gloeckler, JM | 1 |
| Kakar, S; Lee, GS; Maher, JJ; Ng, RK; Yan, JS | 1 |
| Ikejima, K; Kon, K; Okumura, K; Sato, N; Takei, Y | 1 |
| Zeisel, SH | 1 |
| Adegboyega, P; Allman, M; Rivera, CA; Tagalicud, A; van Rooijen, N; Wallace, M | 1 |
| Bader, M; Clavien, PA; Dahm, F; Georgiev, P; Jang, JH; Jochum, W; Nocito, A; Renner, EL | 1 |
| Duncan, G; Hay, SM; Maloney, CA; McNeil, CJ; Rees, WD; Reid, M; Rucklidge, GJ | 1 |
| Chen, TS; Neuman, M; Oz, HS | 1 |
| Larter, CZ | 1 |
| van Gulik, TM; van Vliet, A; Veteläinen, R | 1 |
| Augustine, LM; Cherrington, NJ; Fisher, CD; Lickteig, AJ | 1 |
| Bell-Anderson, KS; Brown, S; Cheng, J; dela Pena, A; Farrell, GC; Larter, CZ; Williams, J; Yeh, MM | 1 |
| Ichikawa, T; Kakizaki, S; Mori, M; Sato, K; Takagi, H; Takizawa, D; Yamazaki, Y | 1 |
| Anan, A; Baskin-Bey, ES; Bronk, SF; Gores, GJ; Isomoto, H | 1 |
| Belouze, M; Dautresme, M; Duchamp, C; Favier, R; Letexier, D; Mourier, A; Ollivier, I; Piquet, MA; Rey, B; Rigoulet, M; Romestaing, C; Rouleau, V; Servais, S; Sibille, B | 1 |
| Damjanov, I; French, S; Gyamfi, MA; Wan, YJ | 1 |
| Bahcecioglu, IH; Koca, SS; Ozercan, IH; Poyrazoglu, OK; Sahin, K; Ustundag, B | 1 |
| Chan, HL; Chu, ES; Lin, G; Shen, B; Sung, JJ; Wang, S; Wong, VW; Yu, J; Zhou, X | 1 |
| Borensztajn, J; Elias, MS; Fu, T; Green, RM; Rinella, ME; Smolak, RR | 1 |
| Lu, SC; Martínez-Chantar, ML; Mato, JM | 1 |
| Kumagai, N; Morinaga, S; Sugino, H; Takeuchi, O; Toda, K; Tsuchimoto, K; Tsunematsu, S; Watanabe, S | 1 |
| Almassi, N; Desotelle, JA; Dobosy, JR; Fu, VX; Jarrard, DF; Kenowski, ML; Srinivasan, R; Svaren, J; Weindruch, R | 1 |
| Ando, H; Ishikura, K; Kaneko, S; Kita, Y; Kurita, S; Matsuzawa-Nagata, N; Misu, H; Nabemoto, S; Nakanuma, Y; Ota, T; Takamura, T; Uno, M; Zen, Y | 1 |
| Hegsted, DM; McCombs, HL; Roach, AM | 1 |
| Bressler, R; Corredor, C; Mansbach, C | 1 |
| de Camargo, JL; Nauss, KM; Newbene, PM | 1 |
| Cornatzer, WE; Hoffman, DR; Uthus, EO | 1 |
| Cornatzer, WE; Haning, JA; Hoffman, DR | 1 |
| Farber, E; Ghoshal, AK | 2 |
| Lieber, CS | 1 |
| Farber, E; Ghoshal, AK; Lim, YP; Rushmore, TH | 1 |
| Ahluwalia, M; Farber, E; Ghoshal, AK | 1 |
| Poirier, LA; Shivapurkar, N; Wilson, MJ | 1 |
| Connor, AM; Kavanaugh, A; Nauss, KM; Newberne, PM | 1 |
| Aguilar, TS | 1 |
| Linnell, JC; Mikol, YB; Poirier, LA; Wilson, MJ | 1 |
| Poirier, LA; Shivapurkar, N | 1 |
| Fox, JG; Murphy, JC; Rogers, AE | 1 |
| Barak, AJ; Kemmy, RJ | 1 |
| Nauss, KM; Newberne, PM | 1 |
| Serafin, JA | 1 |
| Connor, AM; Nauss, KM; Newberne, PM | 1 |
| Mikol, YB; Poirier, LA | 1 |
| Kato, T; Matsuo, T; Seri, K | 1 |
| Lenhart, G; Morrison, G; Rogers, AE | 1 |
| Harper, AE; Pesti, GM; Sunde, ML | 1 |
| ApSimon, MM; Kirkland, JB; Rawling, JM | 1 |
| Christman, JK | 1 |
| Henning, SM; Jacob, RA; Pianalto, FS; Swendseid, ME; Zhang, JZ | 1 |
| Rogers, AE | 1 |
| Baik, MG; Choi, CB; Keller, WL; Park, CS | 1 |
| Jahnke-Spinnenweber, J; Lombardi, B; Saito, R; Shinozuka, H | 1 |
| Moore, JF; Percy, AK | 1 |
| Bowers, JL; Clouse, ME; Endo, M; Hara, J; Iwai, T; Kruskal, JB; Teramoto, K | 1 |
| Poirier, LA | 1 |
| Bowers, JL; Clouse, ME; Khettry, U; Palombo, JD; Teramoto, K | 1 |
| Blaydes, BS; Fullerton, FR; Greenman, DL; Poirier, LA | 1 |
| Denda, A; Endoh, T; Horiguchi, K; Kobayashi, E; Konishi, Y; Nakae, D; Noguchi, O; Ogasawara, H; Sugimura, M; Tamura, K; Tang, Q; Tsujiuchi, T | 1 |
| Andoh, N; Fukuda, T; Kido, A; Kitada, H; Kobayashi, E; Mizumoto, Y; Nakae, D; Ohashi, K; Tsujiuchi, T; Tsutsumi, M | 1 |
| Counts, JL; Downing, JC; Goodman, JL; Harbison, ML; McClain, RM; Sarmiento, JI | 1 |
| Bhopatkar, MY; Faraci, FM; Heistad, DD; Lentz, SR; Malinow, MR; Piegors, DJ; Sobey, CG | 1 |
| Henning, SM; Swendseid, ME | 1 |
| Coulson, WF; Henning, SM; Swendseid, ME | 1 |
| Baek, Y; Barama, A; Boudjema, K; Jaeck, D; Kitamura, N; Kumada, K; Nagasaki, H; Nakano, H; Suzuki, T; Tatsuno, M; Yamaguchi, M | 1 |
| Henning, SM; Ivandic, BT; Liao, F; Swendseid, ME | 1 |
| Baek, Y; Barama, A; Boudjema, K; Fujiwara, Y; Kaneshiro, Y; Kigawa, G; Kitamura, N; Kumada, K; Nagasaki, H; Nakano, H; Sasaki, J; Shimura, H; Tatsuno, M; Yamaguchi, M | 1 |
| Chawla, RK; Eastin, CE; Lee, EY; McClain, CJ; Schmidt, J; Watson, WH | 1 |
| Le Leu, RK; McIntosh, GH; Young, GP | 1 |
| Cronin, GM; Lopatina, NG; Poirier, LA; Vanyushin, BF | 1 |
| Fujiwara, Y; Kaneshiro, Y; Kigawa, G; Kitamura, N; Kumada, K; Kuzume, M; Matsumoto, F; Nagasaki, H; Nakano, H; Sasaki, J; Takeuchi, S; Yamaguchi, M; Yoshida, K | 1 |
| Fujiwara, Y; Kigawa, G; Kitamura, N; Kumada, K; Kuzume, M; Nagasaki, H; Nakano, H; Sasaki, J; Shimura, H; Takeuchi, S; Yamaguchi, M; Yoshida, K | 1 |
| Farrell, GC; Weltman, M; Zhang, BH | 1 |
| Baker, DH; Edwards, HM; Emmert, JL; Mavromichalis, I; Parr, TM; Peter, CM; Strunk, CS | 1 |
| Bell, DR; Farrell, GC; Field, J; Gonzalez, FJ; Leclercq, IA; Robertson, GR | 1 |
| Brand, GM; Duthie, SJ; Grant, G; Narayanan, S | 1 |
| Duthie, SJ; Grant, G; Narayanan, S | 1 |
| Deng, L; Hiou-Tim, F; James, SJ; Melnyk, S; Pogribny, IP; Rozen, R; Sibani, S; Trasler, J; Wang, W | 1 |
| Barak, AJ; Sorrell, MF; Tuma, DJ | 1 |
| Kaul, S; Saxena, SC | 1 |
| Grantham, PH; Poirier, LA; Rogers, AE | 1 |
| Gebhardt, BM; Morton, B; Newberne, PM; Williams, EA | 1 |
| Lombardi, B | 1 |
| Cornwell, PE; Krumdieck, CL; Leichter, J; Thompson, RW | 1 |
| Jensen, LS; Kushwaha, RP | 1 |
| Leveille, GA; Romsos, DR; Tsai, AC | 2 |
| Giotas, C; Lyman, RL; Medwadowski, B; Miljanich, P | 1 |
| Lombardi, B; Rao, NK | 1 |
| Cross, DR; James, SJ; Miller, BJ | 1 |
| Laver, GW; McMullen, E; Mehta, R; Stapley, R | 1 |
| Nishimaki-Mogami, T; Tijburg, LB; Vance, DE | 1 |
| Tijburg, LB; Vance, DE | 1 |
| Christman, JK; Dizik, M; Wainfan, E | 1 |
| Groopman, JD; Newberne, PM; Pikul, AH; Schrager, TF | 1 |
| Jamil, H; Vance, DE; Yao, ZM | 1 |
| Lyn-Cook, B; Poirier, LA; Zapisek, W | 1 |
| Moran, S; Pitot, HC; Poirier, L; Sawada, N; Xu, YH | 1 |
| Denda, A; Kitazawa, S; Konishi, Y; Mizumoto, K; Tsutsumi, M | 1 |
| Hegi, ME; Lutz, WK; Richter, C; Sagelsdorff, P; Ulrich, D | 1 |
| Andry, CD; Kupchik, HZ; Rogers, AE | 1 |
| Newberne, PM; Rogers, AE | 2 |
| Bruckschen, M; Pott, U; Sies, H; Wagner, G | 1 |
| James, SJ; Yin, L | 1 |
| Henning, SM; McKee, RW; Swendseid, ME | 2 |
| Dizik, M; Hoshina, S; Hsieh, LL; Wainfan, E; Weinstein, IB | 1 |
| Cook, RJ; Horne, DW; Wagner, C | 2 |
| James, SJ; Swendseid, ME; Yin, L | 1 |
| daCosta, KA; Pomfret, EA; Zeisel, SH; Zola, T | 1 |
| Christman, JK; Dizik, M; Stender, M; Wainfan, E | 1 |
| Farber, E; Ghoshal, AK; Rushmore, TH | 1 |
| Ridgway, ND; Vance, DE; Yao, Z | 1 |
| Knepp, CR; Nelson, PE; Wilson, TM | 1 |
| Olson, JW | 1 |
| Newberne, PM | 1 |
| Monserrat, AJ; Perazzo, JC; Roberti, MF | 1 |
| Denda, A; Konishi, Y; Mizumoto, K; Tsutsumi, M | 1 |
| Vance, DE; Yao, ZM | 1 |
| Dizik, M; Kilkenny, M; Wainfan, E | 1 |
| Ahluwalia, M; Farber, E; Ghoshal, A; Ghoshal, AK; Roomi, MW; Rushmore, TH; Simmonds, W | 1 |
| Ketterer, B; Meyer, DJ; Tan, KH | 1 |
| Chander, A; Dodia, C; Fisher, AB; Yost, RW | 1 |
| Farber, E; Ghoshal, AK; Sarma, DS | 1 |
| Farber, E; Ghazarian, DM; Ghoshal, AK; Rushmore, TH; Subrahmanyan, V | 1 |
| Hoover, KL; Poirier, LA | 1 |
| Boyd, JN; Graham, ES; Graham, TC; Sherman, WK; Tennant, BC | 1 |
| Chander, A; Fisher, AB; Yost, RW | 1 |
| Balis, ME; Dizik, M; Hluboky, M; Wainfan, E | 1 |
| Aoyama, Y; Ashida, K; Yasui, H | 1 |
| Morris, HP; Petri, WA; Poirier, LA | 1 |
| Woodard, JC | 1 |
| Kobayashi, M; Kotake, Y; Suzuki, S | 1 |
| Thompson, W; Wong, ER | 1 |
| Bruni, C; Hegsted, DM | 1 |
| Gottlieb, LS; Hegsted, DM; Iseri, OA; Vitale, JJ | 1 |
| Ketola, HG; Nesheim, MC | 1 |
| Lyman, RL; Sheehan, G; Tinoco, J | 2 |
| Fuller, HL; Keshavarz, K | 1 |
| Beare-Rogers, JL | 1 |
| Kobayashi, M | 1 |
| Haggard, JH; Parks, PF | 1 |
| Austin, W; Glenn, JL | 1 |
| Jensen, LS; Latshaw, JD | 1 |
| Ceballos, E; Leach, RM; Nesheim, MC; Norvell, MJ | 1 |
| Blumenstein, J | 1 |
| Milova, GN; Pokrovskiĭ, AA; Usacheva, NT | 1 |
| Bailey, C; Newberne, PM; Rogers, AE; Young, VR | 1 |
| Lombardi, B; Pani, P; Schlunk, FF; Shi-Hua, C | 1 |
| Isozaki, M; Sano, M; Yamamoto, A | 1 |
| Sidransky, H; Verney, E | 1 |
| MacDonald, G; Mookerjea, S; Thompson, W | 1 |
| Remy, CN; Wells, IC | 1 |
| Chahl, JS; Kratzing, CC | 1 |
| Chaplin, MD; Mulford, DJ | 1 |
| Newberne, PM; Young, VR | 1 |
20 review(s) available for methionine and Choline Deficiency
| Article | Year |
|---|---|
A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Hepatocytes; Humans; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Transcriptome | 2022 |
Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights.
Topics: Animals; Choline Deficiency; Diet, Western; Disease Models, Animal; Humans; Methionine; Non-alcoholic Fatty Liver Disease | 2018 |
Animal models of NASH: getting both pathology and metabolic context right.
Topics: Animals; Choline Deficiency; Diet, Atherogenic; Dietary Fats; Disease Models, Animal; Disease Progression; Fatty Liver; Genetic Predisposition to Disease; Hyperphagia; Intubation, Gastrointestinal; Liver; Methionine; Overnutrition; Phenotype; Reproducibility of Results | 2008 |
Animal models of non-alcoholic steatohepatitis: of mice and man.
Topics: Animals; Choline Deficiency; Dietary Fats; Disease Models, Animal; Fatty Liver; Humans; Liver; Methionine; Mice | 2010 |
The hepatocarcinogenic effect of methionine and choline deficient diets: an adaptation to the Warburg effect?
Topics: Adaptation, Physiological; Animals; Carcinoma, Hepatocellular; Choline Deficiency; Fatty Liver; Humans; Liver Neoplasms; Methionine | 2011 |
Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver.
Topics: Animals; Carcinogens; Choline; Choline Deficiency; Diet; DNA Methylation; Folic Acid Deficiency; Gastrectomy; Liver; Liver Neoplasms, Experimental; Methionine; Models, Biological; Rats; Vitamin B 12 Deficiency | 2003 |
DNA methylation, cancer susceptibility, and nutrient interactions.
Topics: Animals; Choline Deficiency; Deficiency Diseases; Diet; Disease Susceptibility; DNA Methylation; Folic Acid; Folic Acid Deficiency; Humans; Methionine; Neoplasms; Selenium | 2004 |
Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline.
Topics: Animals; Brain; Choline; Choline Deficiency; Diet; Epigenesis, Genetic; Estrogens; Folic Acid; Humans; Methionine; Nutritional Requirements; Polymorphism, Genetic; Response Elements; Vitamin B Complex | 2007 |
Methionine metabolism and liver disease.
Topics: Animals; Choline; Choline Deficiency; Folic Acid Deficiency; Humans; Liver Diseases; Liver Neoplasms; Methionine; Methionine Adenosyltransferase; Methylation | 2008 |
Alcohol-nutrition interaction.
Topics: Alcoholism; Amino Acids; Choline Deficiency; Hepatic Encephalopathy; Humans; Liver Cirrhosis, Alcoholic; Methionine; Nutrition Disorders; Proline; Tryptophan; Vitamins | 1984 |
Effects of dietary folate, vitamin B12 and methionine/choline deficiency on immune function.
Topics: Animals; Antibody Formation; Choline Deficiency; Deoxyuridine; Drug Interactions; Folic Acid; Folic Acid Deficiency; Humans; Hypersensitivity, Delayed; Immunity; Lymphocyte Activation; Lymphocytes; Lymphoid Tissue; Methionine; Vitamin B 12; Vitamin B 12 Deficiency | 1981 |
Lipotrope deficiency and persistent changes in DNA methylation. Lipotrope deficiency and DNA methylation.
Topics: Animals; Choline Deficiency; DNA; Folic Acid Deficiency; Humans; Lipid Metabolism; Liver; Methionine; Methylation; Neoplasms; Vitamin B 12 Deficiency | 1995 |
Methyl donors in the diet and responses to chemical carcinogens.
Topics: Animals; Carcinogens; Choline Deficiency; Diet; Folic Acid Deficiency; Humans; Liver Neoplasms, Experimental; Methionine; Methylation; Neoplasms | 1995 |
Methyl group deficiency in hepatocarcinogenesis.
Topics: Animals; Choline Deficiency; Diet; Folic Acid Deficiency; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Methionine; Methylation; Oncogenes; S-Adenosylmethionine | 1994 |
The role of folate, choline, and methionine in carcinogenesis induced by methyl-deficient diets.
Topics: Animals; Choline; Choline Deficiency; Diet; Folic Acid; Folic Acid Deficiency; Humans; Liver Neoplasms; Methionine; Neoplasms | 1996 |
Influence of dietary factors on the pancreatotoxicity of ethionine.
Topics: Acute Disease; Age Factors; Animals; Choline Deficiency; Diet; Disease Models, Animal; Enzyme Precursors; Ethionine; Female; Hemorrhage; Humans; Male; Methionine; Necrosis; Pancreas; Pancreatitis; Phosphatidylcholines; Sex Factors | 1976 |
Physiological methylation in carcinogenesis.
Topics: Animals; Choline Deficiency; DNA; Humans; Liver Neoplasms; Methionine; Methylation; Oxidation-Reduction; S-Adenosylmethionine | 1990 |
Labile methyl groups and the promotion of cancer.
Topics: Animals; Antibody Formation; Carcinogens; Choline; Choline Deficiency; Diet; DNA; Folic Acid; Folic Acid Deficiency; Humans; Immunity, Cellular; Lipotropic Agents; Liver; Liver Neoplasms; Methionine; Methylation; Neoplasms; Neoplasms, Experimental; Pharmaceutical Preparations; Risk; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1986 |
Dietary methyl groups and cancer.
Topics: Animals; Choline Deficiency; Diet; Liver Neoplasms; Methionine; Methylation; Neoplasms, Experimental; Rats | 1986 |
Nutritional factors in choline deficiency.
Topics: Animals; Choline Deficiency; Diet; Methionine; Rats; Vitamin B 12 | 1968 |
2 trial(s) available for methionine and Choline Deficiency
| Article | Year |
|---|---|
Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load.
Topics: Adult; Analysis of Variance; Animals; Choline; Choline Deficiency; Cross-Over Studies; Homocysteine; Humans; Lipotropic Agents; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred C57BL; Middle Aged; Nutritional Status; Pilot Projects | 2005 |
In vivo methylation capacity is not impaired in healthy men during short-term dietary folate and methyl group restriction.
Topics: Administration, Oral; Adult; Carnitine; Choline; Choline Deficiency; Creatinine; Cross-Over Studies; Diet; Folic Acid; Folic Acid Deficiency; Food, Fortified; Humans; Male; Methionine; Methylation; Middle Aged; Niacinamide; Time Factors | 1995 |
457 other study(ies) available for methionine and Choline Deficiency
| Article | Year |
|---|---|
Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis.
Topics: Animals; Choline Deficiency; Chylomicrons; Diet; Fatty Liver; Female; Fibrosis; Inflammation; Intestines; Male; Methionine; Mice; Mice, Knockout; Mice, Transgenic; Non-alcoholic Fatty Liver Disease | 2021 |
Zonarol Protected Liver from Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in a Mouse Model.
Topics: Animals; Biomarkers; Choline Deficiency; Diet; Disease Models, Animal; Hepatocytes; Immunohistochemistry; Lipid Metabolism; Liver; Male; Methionine; Mice; Models, Biological; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Protective Agents; Sesquiterpenes; Signal Transduction | 2021 |
Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartate Aminotransferases; Biomarkers; Catalase; Choline; Choline Deficiency; Diet; DNA Damage; Glutathione Peroxidase; Inflammation; Liver; Melatonin; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Superoxide Dismutase; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2022 |
Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism.
Topics: Animals; Chlorogenic Acid; Choline; Choline Deficiency; Diet; Endothelial Cells; HMGB1 Protein; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Indole supplementation ameliorates MCD-induced NASH in mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; Indoles; Inflammation; Lipopolysaccharides; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2022 |
Exploring the Therapeutic Effects of Black Ginseng on Non-Alcoholic Fatty Liver Disease by Using Network Pharmacology and Molecular Docking.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Ginsenosides; Liver; Methionine; Mice; Molecular Docking Simulation; Network Pharmacology; Non-alcoholic Fatty Liver Disease; Panax; Proto-Oncogene Proteins c-akt | 2022 |
Low-Dose Administration of Cannabigerol Attenuates Inflammation and Fibrosis Associated with Methionine/Choline Deficient Diet-Induced NASH Model via Modulation of Cannabinoid Receptor.
Topics: Animals; Body Weight; Choline; Choline Deficiency; Diet; Fibrosis; Humans; Inflammation; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Racemethionine; Receptors, Cannabinoid | 2022 |
Theabrownin ameliorates liver inflammation, oxidative stress, and fibrosis in MCD diet-fed C57BL/6J mice.
Topics: Animals; Choline; Choline Deficiency; Diabetes Mellitus, Type 2; Diet; Fibrosis; Inflammation; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Racemethionine; Tea | 2023 |
Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
Topics: Animals; Choline; Choline Deficiency; Diet; Dual-Specificity Phosphatases; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Non-alcoholic Fatty Liver Disease; Osteoprotegerin; Racemethionine | 2023 |
Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fibrosis; Interleukin-8; Liver; Liver Cirrhosis; Liver Neoplasms; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2023 |
Icariin Supplementation Suppresses the Markers of Ferroptosis and Attenuates the Progression of Nonalcoholic Steatohepatitis in Mice Fed a Methionine Choline-Deficient Diet.
Topics: Animals; Choline; Choline Deficiency; Diet; Dietary Supplements; Ferroptosis; Flavonoids; Liver; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Racemethionine | 2023 |
Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice.
Topics: Animals; Bile Acids and Salts; Caulobacteraceae; Choline Deficiency; Diet; Firmicutes; Gastrointestinal Microbiome; Lipids; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Racemethionine; RNA, Messenger | 2023 |
Study of Methionine Choline Deficient Diet-Induced Steatosis in Mice Using Endogenous Fluorescence Spectroscopy.
Topics: Adipose Tissue; Animals; Area Under Curve; Choline Deficiency; Discriminant Analysis; Disease Models, Animal; Disease Progression; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Principal Component Analysis; ROC Curve; Sensitivity and Specificity; Severity of Illness Index; Spectrometry, Fluorescence | 2019 |
Variations in hepatic lipid species of age-matched male mice fed a methionine-choline-deficient diet and housed in different animal facilities.
Topics: Actins; Animal Experimentation; Animals; Calcium-Binding Proteins; Ceramides; Cholesterol; Choline Deficiency; Diet; Disease Models, Animal; Gene Expression Regulation; Interleukin-6; Liver; Lysophosphatidylcholines; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Receptors, G-Protein-Coupled; Sphingomyelins; Transforming Growth Factor beta; Triglycerides | 2019 |
L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet.
Topics: Animals; Carnitine; Choline Deficiency; Diet; Dietary Supplements; Disease Models, Animal; Disease Progression; Heart Diseases; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Reactive Oxygen Species | 2020 |
Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation-Mediated Cell Death in Mice.
Topics: Animals; Apoptosis; Cell Death; Choline Deficiency; Diet; Disease Progression; Ferroptosis; Inflammation; Lipid Peroxidation; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phospholipid Hydroperoxide Glutathione Peroxidase | 2020 |
Cigarette smoking differentially regulates inflammatory responses in a mouse model of nonalcoholic steatohepatitis depending on exposure time point.
Topics: Animals; Body Weight; Choline Deficiency; Cigarette Smoking; Cytokines; Diet, High-Fat; Disease Progression; Inflammation; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; Mice, Inbred C57BL; Monocytes; Non-alcoholic Fatty Liver Disease; Organ Size; PPAR gamma; Time Factors | 2020 |
Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Choline Deficiency; Curcumin; Disease Models, Animal; Endoplasmic Reticulum Stress; Glycosylation; Hexosamines; Inflammation Mediators; Liver; Male; Methionine; Mice, Inbred C57BL; N-Acetylglucosaminyltransferases; NF-kappa B; Non-alcoholic Fatty Liver Disease; Signal Transduction; Sirtuin 1; Superoxide Dismutase-1 | 2019 |
Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis.
Topics: Animals; Choline Deficiency; Collagen Type I; Cyclophilins; Diet; Disease Models, Animal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Male; Methionine; Mice; Molecular Targeted Therapy; Non-alcoholic Fatty Liver Disease | 2019 |
Hepatic NK cells attenuate fibrosis progression of non-alcoholic steatohepatitis in dependent of CXCL10-mediated recruitment.
Topics: Animals; Choline Deficiency; Fibrosis; Killer Cells, Natural; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation.
Topics: Adult; Animals; beta-Arrestin 1; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Disease Progression; Female; Golgi Apparatus; Growth Differentiation Factor 15; Humans; Lipogenesis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Non-alcoholic Fatty Liver Disease; Signal Transduction; Young Adult | 2020 |
Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice.
Topics: Animals; Choline Deficiency; Cytokines; Diet; Drug Liberation; Flavonoids; Liposomes; Liver; Male; Methionine; Mice, Inbred C57BL; Nanoparticles; Non-alcoholic Fatty Liver Disease; Toll-Like Receptor 4 | 2020 |
Role of hepatic neuropeptide Y-Y1 receptors in a methionine-choline-deficient model of non-alcoholic steatohepatitis.
Topics: Animals; Blotting, Western; Choline Deficiency; Disease Models, Animal; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Receptors, Neuropeptide Y; Triglycerides | 2020 |
Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity.
Topics: Animals; Choline; Choline Deficiency; Diet; Ferroptosis; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4α-dependent very low-density lipoprotein.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Flavonoids; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Lipoproteins, VLDL; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Protein Kinase C; Secretory Pathway; Signal Transduction; Treatment Outcome | 2020 |
Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Gene Expression; Gene Knockout Techniques; Glucagon-Like Peptide 1; Inflammation; Intestinal Mucosa; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Permeability; Protein Tyrosine Phosphatase, Non-Receptor Type 1; RAW 264.7 Cells | 2020 |
Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice.
Topics: Animals; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Non-alcoholic Fatty Liver Disease | 2020 |
CREBH knockout accelerates hepatic fibrosis in mouse models of diet-induced nonalcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Choline Deficiency; Cyclic AMP Response Element-Binding Protein; Diet, High-Fat; Fibroblast Growth Factors; Hydroxyproline; Lipids; Liver Cirrhosis; Male; Methionine; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Signal Transduction; Transforming Growth Factor beta | 2020 |
Disruption of hepatic one-carbon metabolism impairs mitochondrial function and enhances macrophage activity in methionine-choline-deficient mice.
Topics: Adenosine; Animals; Carbon; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Flavins; Guanidine; Inflammation; Liver; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Nucleotides; Purinergic P1 Receptor Antagonists; Thymidine | 2020 |
Resveratrol prevents liver damage in MCD-induced steatohepatitis mice by promoting SIGIRR gene transcription.
Topics: Alanine Transaminase; Animals; Antioxidants; Choline Deficiency; Disease Models, Animal; Hepatocytes; Humans; Interleukin-1beta; Interleukin-6; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Receptors, Interleukin-1; Resveratrol; Toll-Like Receptors; Transcription, Genetic; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2020 |
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice.
Topics: Animals; Arachidonate 12-Lipoxygenase; Choline; Choline Deficiency; Diet; Disease Models, Animal; Hepatic Stellate Cells; Isoenzymes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2020 |
HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Choline Deficiency; Inflammation Mediators; Lipid Metabolism; Lipogenesis; Lipolysis; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; Signal Transduction | 2020 |
Automated thermal imaging for the detection of fatty liver disease.
Topics: Algorithms; Animals; Automation; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Female; Humans; Image Processing, Computer-Assisted; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Thermography; Ultrasonography | 2020 |
Live Confocal Imaging as a Novel Tool to Assess Liver Quality: Insights From a Murine Model.
Topics: Animals; Biopsy; Choline Deficiency; Cold Ischemia; Disease Models, Animal; Fatty Liver, Alcoholic; Liver; Male; Methionine; Mice, Inbred C57BL; Microscopy, Confocal; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; Reperfusion; Reperfusion Injury; Time Factors; Tissue Survival; Warm Ischemia | 2020 |
Plasma lipoprotein profile from nonalcoholic steatohepatitis model rats.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Choline Deficiency; Chylomicrons; Diet; Disease Models, Animal; Eating; Insulin; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Particle Size; Rats; Rats, Sprague-Dawley; Triglycerides | 2020 |
Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.
Topics: alpha-Fetoproteins; Animal Feed; Animals; Carcinoma, Hepatocellular; Ceramides; Choline; Choline Deficiency; Diethylnitrosamine; Disease Models, Animal; Humans; Lipidomics; Lipids; Lipogenesis; Liver; Liver Cirrhosis; Liver Neoplasms; Lysophosphatidylcholines; Male; Mass Spectrometry; Methionine; Mice; Mice, Inbred C3H; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2020 |
Associations between serum trace elements and inflammation in two animal models of nonalcoholic fatty liver disease.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Rats, Zucker; Trace Elements | 2020 |
A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet.
Topics: Amino Acids; Animal Feed; Animals; Apoptosis; Body Weight; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Humans; Inflammation; Insulin-Like Growth Factor I; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Organ Size; Phosphorylation; RNA; Soybean Oil; Sulfotransferases; Trans Fatty Acids | 2020 |
Beneficial and deleterious effects of sitagliptin on a methionine/choline-deficient diet-induced steatohepatitis in rats.
Topics: Animals; Choline Deficiency; Diet; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Sitagliptin Phosphate | 2021 |
ER stress-induced adipocytes secrete-aldo-keto reductase 1B7-containing exosomes that cause nonalcoholic steatohepatitis in mice.
Topics: Adipocytes; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Choline Deficiency; Chromatography, Liquid; Disease Models, Animal; Exosomes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Tandem Mass Spectrometry | 2021 |
Deficiency in Tissue Non-Specific Alkaline Phosphatase Leads to Steatohepatitis in Mice Fed a High Fat Diet Similar to That Produced by a Methionine and Choline Deficient Diet.
Topics: Alkaline Phosphatase; Alleles; Animals; Choline; Choline Deficiency; Diet; Diet, High-Fat; Disease Models, Animal; Enzyme Activation; Fatty Liver; Methionine; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; PPAR alpha; Proto-Oncogene Proteins c-akt; Signal Transduction | 2020 |
A Mineralocorticoid Receptor Deficiency in Myeloid Cells Reduces Liver Steatosis by Impairing Activation of CD8
Topics: Adaptive Immunity; Animals; CD8-Positive T-Lymphocytes; Choline Deficiency; Diet; Disease Models, Animal; Female; Hepatitis; Inflammation; Liver Cirrhosis; Lymphocyte Activation; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; Non-alcoholic Fatty Liver Disease; Receptors, Mineralocorticoid | 2020 |
Multiparametric ultrasound imaging for the assessment of normal versus steatotic livers.
Topics: Animals; Choline Deficiency; Elasticity Imaging Techniques; Food, Formulated; Liver; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2021 |
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Cytokines; Diet; Fatty Liver; Hep G2 Cells; Humans; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Oxidative Stress; Prolyl Oligopeptidases; Signal Transduction | 2021 |
Visfatin exacerbates hepatic inflammation and fibrosis in a methionine-choline-deficient diet mouse model.
Topics: Adipokines; Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Nicotinamide Phosphoribosyltransferase; Non-alcoholic Fatty Liver Disease | 2021 |
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics.
Topics: Animals; Choline; Choline Deficiency; Folic Acid Deficiency; Kynurenine; Male; Methionine; Methylation; Probiotics; Rats; Rats, Sprague-Dawley; Tryptophan | 2021 |
Hepatocyte-specific deletion of Nlrp6 in mice exacerbates the development of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Hepatocytes; Humans; Intracellular Signaling Peptides and Proteins; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Receptors, Cell Surface | 2021 |
Salvia-Nelumbinis naturalis extract protects mice against MCD diet-induced steatohepatitis via activation of colonic FXR-FGF15 pathway.
Topics: Animals; Choline Deficiency; Colon; Diet; Drugs, Chinese Herbal; Dysbiosis; Fibroblast Growth Factors; Gastrointestinal Microbiome; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Protective Agents; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2021 |
Baking of methionine-choline deficient diet aggravates testis injury in mice.
Topics: Animals; Apoptosis; Choline Deficiency; Cooking; Diet; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Male; Methionine; Mice; Mice, Inbred C57BL; Sperm Count; Sperm Motility; Spermatocytes; Testis | 2021 |
Soyasaponin A
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Choline Deficiency; Colon; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Saponins | 2021 |
Long-term cold storage preservation does not affect fatty livers from rats fed with a methionine and choline deficient diet.
Topics: Animals; Choline; Choline Deficiency; Diet; Fatty Liver; Liver; Male; Methionine; Rats; Rats, Wistar; Tissue Preservation | 2021 |
Shc inhibitor idebenone ameliorates liver injury and fibrosis in dietary NASH in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Diet; Disease Models, Animal; Fast Foods; Leukocytes, Mononuclear; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphorylation; Protective Agents; Shc Signaling Adaptor Proteins; Signal Transduction; Therapeutics; Ubiquinone | 2021 |
Nonobese mice with nonalcoholic steatohepatitis fed on a choline-deficient, l-amino acid-defined, high-fat diet exhibit alterations in signaling pathways.
Topics: Amino Acids; Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Signal Transduction | 2021 |
Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice.
Topics: Adenoviridae; Adipose Tissue; Alanine Transaminase; Animals; Choline Deficiency; Collagen Type I; Collagen Type III; Diet; Disease Models, Animal; Down-Regulation; Eye Proteins; Fatty Liver; Injections, Intramuscular; Interleukin-1beta; Interleukin-6; Kupffer Cells; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nerve Growth Factors; Oxidative Stress; PPAR gamma; Protease Inhibitors; RNA, Messenger; Serpins; Tumor Necrosis Factor-alpha; Up-Regulation | 2017 |
Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Female; Gastrointestinal Microbiome; Gene Expression Profiling; Liver; Male; Maternal Nutritional Physiological Phenomena; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Overnutrition; Pregnancy; Prenatal Exposure Delayed Effects | 2017 |
Hyperpolarized
Topics: Animals; Ascorbic Acid; Carbon-13 Magnetic Resonance Spectroscopy; Choline Deficiency; Dehydroascorbic Acid; Diet; Disease Models, Animal; Lipid Metabolism; Liver; Magnetic Resonance Imaging; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2017 |
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Topics: Amino Acid Oxidoreductases; Animals; Cell Proliferation; Cell Transdifferentiation; Cells, Cultured; Choline Deficiency; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Induction; Extracellular Matrix; Forkhead Box Protein O1; Genetic Predisposition to Disease; Hepatic Stellate Cells; Hepatocytes; Humans; Insulin Resistance; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Phenotype; Receptor, Insulin; Signal Transduction | 2017 |
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
Topics: Activating Transcription Factor 4; AMP-Activated Protein Kinases; Animals; Autophagy; Carbon Monoxide; Choline Deficiency; Disease Models, Animal; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Fatty Liver; Gene Expression Regulation; Hepatocytes; Liver; Male; Mechanistic Target of Rapamycin Complex 1; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Nuclear Proteins; Organometallic Compounds; Peroxidases; Primary Cell Culture; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction | 2017 |
Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Intestines; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oligosaccharides; Prebiotics | 2017 |
Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice.
Topics: Animals; Biomarkers; Choline Deficiency; Cytokine Receptor gp130; Dietary Supplements; Disease Models, Animal; Humans; Inflammation; Interleukin-6; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Non-alcoholic Fatty Liver Disease | 2017 |
Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Topics: Animals; Cell Cycle Proteins; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fatty Acid Transport Proteins; Fatty Acid-Binding Proteins; Fatty Acids; Glycerophospholipids; Hepatocytes; Male; Methionine; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Nuclear Proteins; Phosphatidate Phosphatase; Phospholipase D; RNA, Messenger; Transferases (Other Substituted Phosphate Groups); Transforming Growth Factor beta; Triglycerides; Tumor Necrosis Factor-alpha | 2017 |
Editor's Highlight: PCB126 Exposure Increases Risk for Peripheral Vascular Diseases in a Liver Injury Mouse Model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Disease Models, Animal; Energy Metabolism; Environmental Pollutants; Gene Expression Regulation; Inflammation Mediators; Liver; Liver Cirrhosis; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Peripheral Vascular Diseases; Polychlorinated Biphenyls | 2017 |
Role of ADAMTS13 in diet-induced liver steatosis.
Topics: ADAMTS13 Protein; Animals; Body Weight; CD36 Antigens; Choline Deficiency; Diet; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Tissue Inhibitor of Metalloproteinase-1; Triglycerides; von Willebrand Factor | 2017 |
Asking the Right Questions With Animal Models: Methionine- and Choline-Deficient Model in Predicting Adverse Drug Reactions in Human NASH.
Topics: Animals; Biological Transport; Choline Deficiency; Cytochrome P-450 Enzyme System; Diet; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Humans; Methionine; Non-alcoholic Fatty Liver Disease; Pharmaceutical Preparations; Predictive Value of Tests; Tissue Distribution | 2018 |
Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Chemokine CCL2; Choline Deficiency; Diet; Flavonoids; Interleukin-1beta; Lipid Metabolism; Liver; Liver Cirrhosis; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2018 |
Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Clusterin; Diet; Disease Models, Animal; Hepatocytes; Liver; Male; Methionine; Mice; Mice, Transgenic; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; RNA, Messenger; Up-Regulation | 2018 |
Fatty acids in non-alcoholic steatohepatitis: Focus on pentadecanoic acid.
Topics: Animals; Choline; Choline Deficiency; Disease Models, Animal; Fatty Acids; Hepatocytes; Humans; Liver; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Triglycerides | 2017 |
Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model.
Topics: Adipocytes; Adiponectin; Adiposity; Animals; Body Weight; Calcium-Binding Proteins; Cell Size; Choline Deficiency; Diet, Atherogenic; Disease Models, Animal; Feeding Behavior; Inflammation; Lipase; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Membrane Proteins; Methionine; Mice; Mice, Knockout; Muscle Proteins; Muscle, Skeletal; Myostatin; Non-alcoholic Fatty Liver Disease; Organ Size; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Triglycerides | 2018 |
Butein protects the nonalcoholic fatty liver through mitochondrial reactive oxygen species attenuation in rats.
Topics: Administration, Oral; Albumins; Animals; Chalcones; Choline; Choline Deficiency; Diet; Globulins; Heme Oxygenase (Decyclizing); Hypolipidemic Agents; Liver; Male; Methionine; Mitochondria; Non-alcoholic Fatty Liver Disease; Peroxidase; Rats; Rats, Wistar; Reactive Oxygen Species; Transaminases | 2018 |
Chemerin in a Mouse Model of Non-alcoholic Steatohepatitis and Hepatocarcinogenesis.
Topics: Adiponectin; Animals; Body Composition; Chemokines; Choline Deficiency; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Intercellular Signaling Peptides and Proteins; Liver; Liver Neoplasms, Experimental; Male; Methionine; Mice; Mice, Inbred C3H; Neoplasm Proteins; Non-alcoholic Fatty Liver Disease; Protein Precursors; Receptors, G-Protein-Coupled | 2018 |
Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice.
Topics: Actins; Animals; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Diet; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation; Growth Differentiation Factor 15; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Osteopontin; Primary Cell Culture; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Transcription Factor CHOP; Transforming Growth Factor beta1 | 2018 |
Use of an animal model to test whether non-alcoholic fatty liver disease increases the risk of idiosyncratic drug-induced liver injury.
Topics: Amodiaquine; Animals; Antibodies, Blocking; Chemical and Drug Induced Liver Injury; Choline Deficiency; Disease Models, Animal; Female; Granzymes; Humans; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Programmed Cell Death 1 Receptor; Risk | 2018 |
Investigation of nonalcoholic fatty liver disease-induced drug metabolism by comparative global toxicoproteomics.
Topics: Animals; Choline Deficiency; Chromatography, Liquid; Computational Biology; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Interactions; Isoenzymes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proteomics; Risk Assessment; Substrate Specificity; Tandem Mass Spectrometry; Toxicology; Xenobiotics | 2018 |
Hepatocyte-specific deletion of Brg1 alleviates methionine-and-choline-deficient diet (MCD) induced non-alcoholic steatohepatitis in mice.
Topics: Animals; Cells, Cultured; Choline Deficiency; Diet; DNA Helicases; Epigenesis, Genetic; Gene Deletion; Hepatocytes; Liver; Male; Methionine; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Nuclear Proteins; Transcription Factors; Up-Regulation | 2018 |
Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Dysbiosis; Feces; Gastrointestinal Microbiome; Humans; Intestines; Liver Cirrhosis; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; RNA, Ribosomal, 16S | 2018 |
A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; DNA Helicases; Epigenesis, Genetic; Gene Deletion; Hepatocytes; Histone Acetyltransferases; Methionine; Mice; NADPH Oxidases; Non-alcoholic Fatty Liver Disease; Nuclear Proteins; Promoter Regions, Genetic; Reactive Oxygen Species; Salicylates; Transcription Factors | 2019 |
Silibinin Ameliorates
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; beta-N-Acetylhexosaminidases; Choline Deficiency; Humans; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Peroxiredoxins; Proteomics; RAW 264.7 Cells; Silybin; Silymarin | 2018 |
Molybdate Attenuates Lipid Accumulation in the Livers of Mice Fed a Diet Deficient in Methionine and Choline.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Diet; Lipid Metabolism; Liver; Male; Malondialdehyde; Methionine; Mice, Inbred C57BL; Molybdenum; Non-alcoholic Fatty Liver Disease | 2018 |
Gypenoside UL4-Rich Gynostemma pentaphyllum Extract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease.
Topics: Animals; Choline Deficiency; Dietary Supplements; Gynostemma; Hep G2 Cells; Humans; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phytotherapy; Plant Extracts; Sirtuins | 2018 |
Topics: Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Choline Deficiency; Diet; Inflammation; Interleukin-1beta; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; S100 Calcium-Binding Protein A4; Triglycerides; Tumor Necrosis Factor-alpha | 2018 |
Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Cytokines; Diet, High-Fat; Disease Models, Animal; Inflammation; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Receptors, Nicotinic | 2019 |
Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development.
Topics: Animals; Choline Deficiency; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fatty Liver; Inflammation; Inflammation Mediators; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Schisandra | 2019 |
Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway.
Topics: Adenylate Kinase; Animals; Choline Deficiency; Dose-Response Relationship, Drug; Gallic Acid; Hep G2 Cells; Humans; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Protective Agents; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2019 |
Administration of methyl palmitate prevents non-alcoholic steatohepatitis (NASH) by induction of PPAR-α.
Topics: Animals; Choline Deficiency; Hep G2 Cells; Humans; Lipid Peroxidation; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Palmitates; PPAR alpha | 2019 |
Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Microbiome; Genetic Variation; Humans; Inflammation; Liver Cirrhosis; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2019 |
Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease.
Topics: Animals; Autophagy; Betaine; Choline Deficiency; Gastrointestinal Agents; Inflammation; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
iPla2β deficiency in mice fed with MCD diet does not correct the defect of phospholipid remodeling but attenuates hepatocellular injury via an inhibition of lipid uptake genes.
Topics: Animals; Choline Deficiency; Diet; Female; Gene Deletion; Group VI Phospholipases A2; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Phospholipids | 2019 |
Inhibitory Effects of Sodium Alginate on Hepatic Steatosis in Mice Induced by a Methionine- and Choline-deficient Diet.
Topics: Alginates; Animals; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Fatty Liver; Intestine, Small; Male; Methionine; Mice; Mice, Inbred C57BL; RNA, Messenger; Tumor Necrosis Factor-alpha | 2019 |
Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Folate Receptor 2; Folic Acid; Humans; Liver; Macrophages; Male; Methionine; Mice, Inbred C57BL; Molecular Imaging; Non-alcoholic Fatty Liver Disease; Organotechnetium Compounds; Predictive Value of Tests; Radiopharmaceuticals; Rats, Sprague-Dawley; Tomography, Emission-Computed, Single-Photon | 2019 |
MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice.
Topics: Animals; Cells, Cultured; Choline Deficiency; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Hepatocytes; Interleukin-6; Male; Methionine; Mice; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Smad3 Protein; Transforming Growth Factor beta | 2019 |
Methionine-Choline Deprivation Impairs Adult Hippocampal Neurogenesis in C57BL/6 Mice.
Topics: Animals; Cell Proliferation; Cell Survival; Choline; Choline Deficiency; Hippocampus; Male; Methionine; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis | 2019 |
Betaine attenuates pathology by stimulating lipid oxidation in liver and regulating phospholipid metabolism in brain of methionine-choline-deficient rats.
Topics: Animals; Betaine; Blotting, Western; Choline Deficiency; Lipid Metabolism; Liver; Male; Maze Learning; Methionine; Phospholipids; Rats; Rats, Sprague-Dawley | 2019 |
Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model.
Topics: Animals; Antioxidants; Choline Deficiency; Endoplasmic Reticulum Stress; Glutathione Peroxidase; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Simvastatin; Superoxide Dismutase | 2019 |
Adenovirus‑mediated overexpression of bone morphogenetic protein‑9 promotes methionine choline deficiency‑induced non‑alcoholic steatohepatitis in non‑obese mice.
Topics: Adenoviridae; Animals; Choline Deficiency; Growth Differentiation Factor 2; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; RNA, Messenger; Up-Regulation | 2019 |
The beneficial effects of Nardostachys jatamansi extract on diet-induced severe acute pancreatitis.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Female; Methionine; Mice; Mice, Inbred C57BL; Multiple Organ Failure; Nardostachys; Pancreas; Pancreatitis; Plant Extracts; Plants, Medicinal; Time Factors | 2013 |
Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3.
Topics: Acetylation; Animals; Choline Deficiency; Fatty Liver; Food, Formulated; Gene Expression; Lipid Peroxidation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Polychlorinated Dibenzodioxins; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Sirtuin 3; Superoxide Dismutase | 2013 |
Injury-dependent retention of intraportally administered mesenchymal stromal cells following partial hepatectomy of steatotic liver does not lead to improved liver recovery.
Topics: Analysis of Variance; Animals; Biomarkers; Body Weight; Choline Deficiency; Cholinesterases; DNA Primers; Fatty Liver; Female; Flow Cytometry; Hepatectomy; Immunophenotyping; Liver Regeneration; Luminescent Measurements; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methionine; Organ Size; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; Triglycerides | 2013 |
Chunggan extract (CGX), methionine-and choline-deficient (MCD) diet-induced hepatosteatosis and oxidative stress in C57BL/6 mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Catalase; Cholesterol; Choline Deficiency; Diet; Drugs, Chinese Herbal; Fatty Liver; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Triglycerides | 2013 |
Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Endotoxemia; Fatty Liver; Female; Lipase; Lipopolysaccharides; Liver; Male; Methionine; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; PPAR alpha; Signal Transduction | 2014 |
Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model.
Topics: Animals; Bifidobacterium; Choline Deficiency; Disease Models, Animal; Fatty Liver; Gastrointestinal Tract; Gene Expression Profiling; Inflammation; Lacticaseibacillus casei; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Microbiota; Non-alcoholic Fatty Liver Disease | 2013 |
Effects of treatment with hydrogen sulfide on methionine-choline deficient diet-induced non-alcoholic steatohepatitis in rats.
Topics: Animals; Choline Deficiency; Cytochrome P-450 CYP2E1; Disease Models, Animal; Disease Progression; Fatty Liver; Heme Oxygenase-1; Hydrogen Sulfide; Inflammation; Interleukin-6; Liver; Male; Methionine; Mitochondria, Liver; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2014 |
Dynamics of oxidative/nitrosative stress in mice with methionine-choline-deficient diet-induced nonalcoholic fatty liver disease.
Topics: Animals; Antioxidants; C-Reactive Protein; Catalase; Choline Deficiency; Disease Models, Animal; Ferritins; Glutathione; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Mice, Inbred C57BL; Nitrates; Nitrites; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Superoxide Dismutase; Time Factors | 2014 |
IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet.
Topics: Animals; Cell Line; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Gene Expression Profiling; Hepatic Stellate Cells; Inflammation; Interferon-gamma; Kupffer Cells; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2013 |
Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver.
Topics: Animals; Choline Deficiency; Diabetes Mellitus; Diet; Diet, High-Fat; Fatty Liver; Female; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Obesity; PPAR gamma; Proteins; RNA, Messenger | 2013 |
Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Disease Models, Animal; Early Diagnosis; Genetic Markers; Male; Methionine; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; Severity of Illness Index; Time Factors | 2014 |
Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice.
Topics: Alanine Transaminase; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aspartate Aminotransferases; Biomarkers; Cell Proliferation; Chemokine CCL2; Choline Deficiency; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Kupffer Cells; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proliferating Cell Nuclear Antigen; RNA, Messenger; Time Factors | 2013 |
Dietary glycotoxins exacerbate progression of experimental fatty liver disease.
Topics: Animals; Cell Proliferation; Choline Deficiency; Diet; Disease Progression; Gene Expression; Glycation End Products, Advanced; Hepatic Stellate Cells; Insulin Resistance; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2014 |
Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency.
Topics: Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Choline Deficiency; Fatty Liver; Female; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Methionine; Mice, Inbred C57BL; Middle Aged; Molecular Targeted Therapy | 2014 |
Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models.
Topics: Animals; Choline Deficiency; Diabetes Mellitus, Experimental; Diet, Atherogenic; Disease Models, Animal; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Obesity; Organic Anion Transporters; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2014 |
HIF-1α expression as a protective strategy of HepG2 cells against fatty acid-induced toxicity.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Hypoxia; Cell Survival; Choline Deficiency; Diet; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Expression; Heat-Shock Proteins; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver; Methionine; Mice, Inbred C57BL; Palmitic Acid; Promoter Regions, Genetic; Protective Factors; Protein Binding; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factor CHOP | 2014 |
Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice.
Topics: Animals; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; Carrier Proteins; Chemokine CCL2; Choline Deficiency; Inflammasomes; Interleukin-18; Interleukin-1beta; Liver Diseases, Alcoholic; Methionine; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2013 |
Lipid metabolism, oxidative stress and cell death are regulated by PKC delta in a dietary model of nonalcoholic steatohepatitis.
Topics: Animals; Apoptosis; Biomarkers; Cells, Cultured; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Enzyme Activation; Fatty Liver; Female; Gene Expression; Hepatocytes; Lipid Metabolism; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Primary Cell Culture; Protein Kinase C-delta | 2014 |
n-3 polyunsaturated fatty acids worsen inflammation and fibrosis in experimental nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-6; Inflammation Mediators; Liver; Liver Cirrhosis; Male; Methionine; Mice, Inbred BALB C; Necrosis; Non-alcoholic Fatty Liver Disease; Olive Oil; Plant Oils; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2014 |
Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis.
Topics: Animals; Blotting, Western; Bone Marrow Cells; Carrier Proteins; Choline Deficiency; Diet; DNA-Binding Proteins; Gene Expression Regulation; Immunoprecipitation; Inflammasomes; Methionine; Mice; Mice, Knockout; Myeloid Differentiation Factor 88; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Signal Transduction; Statistics, Nonparametric; Toll-Like Receptor 4; Toll-Like Receptor 9 | 2014 |
Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice.
Topics: Animals; Annexin A1; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Hepatitis; Humans; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Obesity | 2014 |
Effect of Trifolium pratense extract on methionine-choline-deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Animals; Cholesterol; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phytotherapy; Plant Extracts; PPAR gamma; RNA, Messenger; Trifolium; Triglycerides | 2014 |
Bile acids override steatosis in farnesoid X receptor deficient mice in a model of non-alcoholic steatohepatitis.
Topics: Animals; Bile Acids and Salts; Cholestasis, Intrahepatic; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Receptors, Cytoplasmic and Nuclear | 2014 |
Taurine supplementation does not decrease homocysteine levels and liver injury induced by a choline-deficient diet.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Choline Deficiency; Cysteine; Diet; Dietary Supplements; Gene Expression Regulation; Homocysteine; Liver; Malondialdehyde; Methionine; Rats; Taurine | 2014 |
Sitagliptin attenuates methionine/choline-deficient diet-induced steatohepatitis.
Topics: Animals; Biomarkers; Blotting, Western; Choline Deficiency; Diet; Dipeptidyl-Peptidase IV Inhibitors; Endoplasmic Reticulum Stress; Fatty Liver; Immunoenzyme Techniques; Inflammation; Lipid Peroxidation; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Pyrazines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sitagliptin Phosphate; Triazoles; Triglycerides | 2014 |
Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice.
Topics: Animals; Apoptosis; Caspase 8; Choline Deficiency; Diet; Hepatocyte Growth Factor; Hepatocytes; Inflammation; Lipotropic Agents; Liver Cirrhosis; Methionine; Mice; Mice, Knockout; Neutrophil Infiltration; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proto-Oncogene Proteins c-met | 2014 |
Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet.
Topics: Animal Feed; Animals; Apoptosis; Biomarkers; Choline Deficiency; Disease Progression; Drug Administration Schedule; Endoplasmic Reticulum Stress; Fatty Liver; Gastrointestinal Agents; Immunoblotting; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Taurochenodeoxycholic Acid | 2014 |
ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.
Topics: Amitriptyline; Animals; Autophagy; Ceramides; Cholesterol; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Endoplasmic Reticulum Stress; Humans; Liver; Lysosomes; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Permeability; Sphingomyelin Phosphodiesterase; Sphingomyelins | 2014 |
Retinol status and expression of retinol-related proteins in methionine-choline deficient rats.
Topics: Acyltransferases; Aldehyde Dehydrogenase; Animals; beta-Carotene 15,15'-Monooxygenase; Choline Deficiency; Intestinal Mucosa; Kidney; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats, Wistar; Retinol-Binding Proteins, Cellular; Testis; Vitamin A | 2014 |
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Acids; Fibroblast Growth Factors; Hepatitis; Inflammation Mediators; Infusions, Subcutaneous; Lipid Peroxidation; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Recombinant Proteins; RNA, Messenger; Severity of Illness Index; Time Factors | 2014 |
Alpha-lipoic acid affects the oxidative stress in various brain structures in mice with methionine and choline deficiency.
Topics: Animals; Brain; Catalase; Cerebral Cortex; Choline Deficiency; Corpus Striatum; Disease Models, Animal; Glutathione; Hippocampus; Hypothalamus; Lipid Peroxidation; Male; Malondialdehyde; Methionine; Mice; Mice, Inbred C57BL; Nitric Oxide; Oxidative Stress; Superoxide Dismutase; Thioctic Acid | 2015 |
Deficiency of periostin protects mice against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis.
Topics: Animals; Cell Adhesion Molecules; Choline Deficiency; Diet; Humans; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2015 |
Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency.
Topics: AMP-Activated Protein Kinases; Animals; Anthocyanins; Choline Deficiency; Fatty Liver; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Plant Extracts; Ribes; Transcription Factors; Vaccinium myrtillus | 2015 |
Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis.
Topics: Animals; Cholesterol; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Acids; Female; Inflammation Mediators; Iron; Lipid Peroxidation; Liver; Male; Methionine; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; RNA-Binding Proteins; Time Factors; Up-Regulation | 2014 |
6-gingerol protects against nutritional steatohepatitis by regulating key genes related to inflammation and lipid metabolism.
Topics: Animals; Catechols; Chemokine CCL2; Choline Deficiency; Disease Models, Animal; Fatty Alcohols; Fatty Liver; Inflammation; Interleukin-6; Lipid Metabolism; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Plant Extracts; Tumor Necrosis Factor-alpha | 2015 |
MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Cluster Analysis; Diet; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Liver Cirrhosis; Male; Metformin; Methionine; Mice; MicroRNAs; Non-alcoholic Fatty Liver Disease; Transcriptome | 2015 |
The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways.
Topics: 5-Methylcytosine; 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Cytosine; Deoxyguanosine; DNA Methylation; Fatty Liver; Gene Expression Regulation, Enzymologic; Liver; Male; Methionine; Mice, Inbred C57BL; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine | 2015 |
Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus.
Topics: Age Factors; Animals; Choline; Choline Deficiency; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Folic Acid Deficiency; Hippocampus; Homocysteine; Memory; Methionine; Mice; Mice, Inbred C57BL; Models, Animal; Nutritional Requirements; Promoter Regions, Genetic; Receptors, AMPA; Receptors, Glutamate | 2015 |
Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet.
Topics: Adipocytes, White; Animals; CD36 Antigens; Cells, Cultured; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fibroblast Growth Factors; Hepatocytes; Lipase; Lipolysis; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphatidate Phosphatase; PPAR alpha; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Transcription Factors; Triglycerides | 2015 |
Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.
Topics: Alcohol Dehydrogenase; Animals; Choline Deficiency; Diet; Disease Progression; Fatty Liver; Glutathione; Lipid Metabolism; Liver; Methionine; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease | 2015 |
Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis.
Topics: Animals; Biomarkers; Blotting, Western; Choline Deficiency; Diet; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Immunoenzyme Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
MRI versus histological methods for time course monitoring of steatosis amount in a murine model of NAFLD.
Topics: Adipose Tissue; Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Humans; Image Interpretation, Computer-Assisted; Liver; Magnetic Resonance Imaging; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley; Statistics as Topic; Triglycerides | 2015 |
Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Catechin; Choline Deficiency; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Inflammation Mediators; Lipids; Liver; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Signal Transduction; Transforming Growth Factor beta | 2015 |
[Betaine-enriched beet suppresses hyperhomocysteinemia induced by choline deficiency in rats].
Topics: Amino Acids; Animals; Beta vulgaris; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Choline Deficiency; Cysteine; Diet; Dietary Supplements; Homocysteine; Hyperhomocysteinemia; Liver; Methionine; Rats; Rats, Wistar | 2015 |
The Anti-Microbial Peptide LL-37/CRAMP Is Elevated in Patients with Liver Diseases and Acts as a Protective Factor during Mouse Liver Injury.
Topics: Animals; Antimicrobial Cationic Peptides; beta-Defensins; Bile Ducts; Cathelicidins; Choline Deficiency; Complement C5a; Diet Therapy; Humans; Immunologic Factors; Ligation; Liver; Liver Diseases; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout | 2015 |
The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.
Topics: Animals; Apoptosis; Choline Deficiency; Cytoprotection; Diet, High-Fat; Enzyme Inhibitors; Febuxostat; Gout Suppressants; Hyperuricemia; Liver; Liver Cirrhosis, Experimental; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Thiazoles; Uric Acid; Xanthine Oxidase | 2015 |
Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease.
Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Triglycerides | 2015 |
Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline Deficiency; Diet; Dietary Carbohydrates; Disease Models, Animal; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Inbred C3H; Non-alcoholic Fatty Liver Disease; Oleic Acid; Palmitates; Sucrose | 2015 |
Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease.
Topics: Animals; Apoptosis; Choline; Choline Deficiency; Diet; Disease Models, Animal; Humans; Liver; Liver Cirrhosis; Male; Metabolome; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Triglycerides | 2015 |
Protective effect of ursodeoxycholic acid, resveratrol, and N-acetylcysteine on nonalcoholic fatty liver disease in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Choline Deficiency; Cytoprotection; Disease Models, Animal; Hypolipidemic Agents; Lipids; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Rats, Wistar; Resveratrol; Stilbenes; Ursodeoxycholic Acid | 2016 |
Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance.
Topics: Administration, Oral; Animals; Biomarkers; Blood Glucose; Chemical and Drug Induced Liver Injury; Choline Deficiency; Concanavalin A; Cytoprotection; Diet, High-Fat; Disease Models, Animal; Glycine max; Immunologic Factors; Insulin; Insulin Resistance; Lipids; Liver; Metabolic Syndrome; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Plant Extracts; T-Lymphocytes, Regulatory; Time Factors; Tumor Necrosis Factor-alpha | 2015 |
LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.
Topics: Animals; Carrier Proteins; Choline Deficiency; Intracellular Signaling Peptides and Proteins; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Palmitates; Ubiquitin; Ubiquitin-Protein Ligases | 2015 |
Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.
Topics: Animals; Case-Control Studies; Cell Death; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Hepatocytes; Humans; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Palmitic Acid; Rats; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2015 |
CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis.
Topics: Actins; Animals; Antigens, Differentiation; Antigens, Ly; CD11b Antigen; Choline Deficiency; CX3C Chemokine Receptor 1; Dendritic Cells; Diet; Disease Progression; Flow Cytometry; Gene Expression; Immunohistochemistry; Inflammation; Liver; Methionine; Mice, Inbred C57BL; Monocytes; Non-alcoholic Fatty Liver Disease; Receptors, Chemokine; Reverse Transcriptase Polymerase Chain Reaction; Sulfides; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2015 |
CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy.
Topics: Animals; Autophagy; Choline Deficiency; Cytokines; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Humans; Lipogenesis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Receptors, CXCR3; Th1 Cells; Th17 Cells | 2016 |
Evaluation of Nonalcoholic Fatty Liver Disease in C57BL/6J Mice by Using MRI and Histopathologic Analyses.
Topics: Animals; Area Under Curve; Biopsy; Choline Deficiency; Disease Models, Animal; Liver; Magnetic Resonance Imaging; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; Reproducibility of Results; ROC Curve; Severity of Illness Index | 2015 |
Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Choline Deficiency; Cytokines; Drug Evaluation, Preclinical; Gene Expression; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Resveratrol; Stilbenes | 2015 |
The Ethanol Extract from Lonicera japonica Thunb. Regresses Nonalcoholic Steatohepatitis in a Methionine- and Choline-Deficient Diet-Fed Animal Model.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Inflammation; Liver; Liver Cirrhosis; Lonicera; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phytotherapy; Plant Extracts; Signal Transduction | 2015 |
Treatment with geraniol ameliorates methionine-choline-deficient diet-induced non-alcoholic steatohepatitis in rats.
Topics: Acyclic Monoterpenes; Adenosine Triphosphate; Animals; Carnitine O-Palmitoyltransferase; Choline Deficiency; DNA, Mitochondrial; Electron Transport Chain Complex Proteins; Gene Expression; Male; Methionine; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidative Stress; PPAR alpha; Prohibitins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Repressor Proteins; Terpenes | 2016 |
Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.
Topics: Animals; Biomarkers; Choline Deficiency; Colon; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Gene Expression Regulation; Hormones, Ectopic; Intercellular Signaling Peptides and Proteins; Kupffer Cells; Liver; Macrophages; Male; Methionine; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Toll-Like Receptor 4; Transcription, Genetic | 2016 |
Relationship between liver tissue stiffness and histopathological findings analyzed by shear wave elastography and compression testing in rats with non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; Elastic Modulus; Elasticity Imaging Techniques; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats, Wistar; Severity of Illness Index | 2016 |
Hepatoprotective Effect and Synergism of Bisdemethoycurcumin against MCD Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cholesterol; Choline; Choline Deficiency; Curcuma; Curcumin; Diarylheptanoids; Drug Synergism; Food, Formulated; Lipogenesis; Liver; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Organ Size; Protective Agents; Silymarin; Triglycerides | 2016 |
Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells.
Topics: Actins; Animals; Blotting, Western; Cells, Cultured; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fluorescent Antibody Technique; Hepatic Stellate Cells; Immunoenzyme Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sirtuin 3; Succinate Dehydrogenase | 2016 |
Ischemia-Reperfusion Injury in Fatty Liver Is Mediated by Activated NADPH Oxidase 2 in Rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cells, Cultured; Choline Deficiency; Deoxyguanosine; Disease Models, Animal; Enzyme Inhibitors; Fatty Liver; HMGB1 Protein; Inflammation Mediators; Interleukin-6; Liver; Macrophages; Male; Membrane Glycoproteins; Methionine; NADPH Oxidase 2; NADPH Oxidases; Necrosis; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Time Factors; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2016 |
Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis.
Topics: Animals; Caspase 1; CCAAT-Enhancer-Binding Proteins; Choline Deficiency; Cytokines; Lipoproteins, LDL; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Perilipin-2; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Triglycerides | 2016 |
Methionine-choline deprivation alters liver and brain acetylcholinesterase activity in C57BL6 mice.
Topics: Acetylcholinesterase; Animals; Brain; Choline Deficiency; Enzyme Activation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Tissue Distribution | 2016 |
Mainstream cigarette smoke accelerates the progression of nonalcoholic steatohepatitis by modulating Kupffer cell-mediated hepatocellular apoptosis in adolescent mice.
Topics: Age Factors; Animals; Apoptosis; Cells, Cultured; Choline Deficiency; Cytokines; Disease Models, Animal; Disease Progression; Hepatocytes; Inflammation Mediators; Kupffer Cells; Male; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Paracrine Communication; Severity of Illness Index; Signal Transduction; Smoke; Smoking; Time Factors | 2016 |
Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system.
Topics: Animals; Cholesterol; Choline Deficiency; CRISPR-Cas Systems; Cyclic AMP Response Element-Binding Protein; Female; Hepatitis, Animal; Hyperlipidemias; Insulin; Intestine, Small; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Sterol Regulatory Element Binding Protein 2; Triglycerides; Up-Regulation | 2016 |
S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway.
Topics: Animals; Antioxidants; Biomarkers; Choline Deficiency; Cysteine; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Hep G2 Cells; Humans; Lipid Peroxidation; Liver; Male; Membrane Proteins; Methionine; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Transfection | 2016 |
Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet.
Topics: Animals; Bupropion; Choline; Choline Deficiency; Cytochrome P-450 CYP2B1; Diet, High-Fat; Disease Models, Animal; Humans; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2016 |
Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice.
Topics: Animals; Apoptosis; Cells, Cultured; Choline Deficiency; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Gene Expression; Hepatic Stellate Cells; Hepatocytes; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Recombinant Proteins | 2016 |
Sex-specific metabolic interactions between liver and adipose tissue in MCD diet-induced non-alcoholic fatty liver disease.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cells, Cultured; Choline Deficiency; Diet; Disease Models, Animal; Female; Fibroblast Growth Factors; Humans; Lipolysis; Liver; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Ovary; Sex Factors; Testis; Uncoupling Protein 1; Up-Regulation | 2016 |
Restriction of dietary methyl donors limits methionine availability and affects the partitioning of dietary methionine for creatine and phosphatidylcholine synthesis in the neonatal piglet.
Topics: Animals; Animals, Newborn; Betaine; Choline Deficiency; Creatine; Diet; Female; Folic Acid Deficiency; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Methylation; Phosphatidylcholines; Protein Biosynthesis; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine; Swine; Swine, Miniature; Tritium | 2016 |
Modeling fatty liver disease in animals: Is there an optimal approach, and is the effort worthwhile?
Topics: Animals; Choline Deficiency; Disease Models, Animal; Humans; Methionine; Mice; Non-alcoholic Fatty Liver Disease | 2016 |
New Potential Biomarker Proteins for Alcoholic Liver Disease Identified by a Comparative Proteomics Approach.
Topics: Animals; Biomarkers; Choline Deficiency; Disease Models, Animal; Gene Expression Regulation; Liver Diseases, Alcoholic; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proteomics | 2017 |
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Topics: Animals; Chenodeoxycholic Acid; Cholestenones; Choline Deficiency; Dose-Response Relationship, Drug; Fibrosis; Gene Expression; Hepatocytes; Lipid Metabolism; Lipogenesis; Liver; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Pregnenediones; Primary Cell Culture; Protective Agents; Receptors, Cytoplasmic and Nuclear | 2017 |
Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency.
Topics: Animals; Asteraceae; Caffeic Acids; Cell Line; Choline Deficiency; Disease Models, Animal; Hep G2 Cells; Hepatocytes; Humans; Inflammation; Lipid Metabolism; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Plant Extracts; Succinates | 2017 |
Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Chemokine CCL2; Chimera; Choline; Choline Deficiency; Down-Regulation; Interleukin-12 Subunit p35; Kupffer Cells; Lipopolysaccharides; Liver; Male; Methionine; Mice; Mice, Knockout; NF-kappa B; Non-alcoholic Fatty Liver Disease; Palmitic Acid; Phosphorylation; PPAR alpha; Tumor Necrosis Factor-alpha; Up-Regulation; Vagotomy; Vagus Nerve; Vagus Nerve Stimulation | 2017 |
An estrogen receptor β-selective agonist inhibits non-alcoholic steatohepatitis in preclinical models by regulating bile acid and xenobiotic receptors.
Topics: Animals; Bile Acids and Salts; Choline Deficiency; Diet; Estrogen Receptor beta; Isoquinolines; Liver; Male; Metabolomics; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease | 2017 |
Modulatory role of Co-enzyme Q10 on methionine and choline deficient diet-induced non-alcoholic steatohepatitis (NASH) in albino rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Biomarkers; Brain-Derived Neurotrophic Factor; Choline; Choline Deficiency; Diet; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Interleukin-6; Liver; Male; Methionine; Neuroprotective Agents; Nitric Oxide; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Serum Albumin; Ubiquinone | 2017 |
β
Topics: Animals; Cell Adhesion Molecules; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Disease Progression; Integrin beta Chains; Liver; Lymphocyte Subsets; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mucoproteins; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2017 |
Suv39h2 deficiency ameliorates diet-induced steatosis in mice.
Topics: Animals; Blotting, Western; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Gene Expression; Histone-Lysine N-Methyltransferase; Liver; Liver Cirrhosis; Methionine; Mice, Inbred C57BL; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Sirtuin 1; Up-Regulation | 2017 |
p16 deficiency promotes nonalcoholic steatohepatitis via regulation of hepatic oxidative stress.
Topics: Animals; Cell Line, Tumor; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p18; Disease Models, Animal; Food, Formulated; Gene Expression Regulation; Hepatocytes; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred BALB C; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidative Stress; RNA, Small Interfering | 2017 |
MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes.
Topics: Adipocytes; Adipogenesis; Adiponectin; Alanine Transaminase; AMP-Activated Protein Kinase Kinases; Animals; Choline Deficiency; Dietary Fats; Disease Models, Animal; Fatty Acid-Binding Proteins; Fatty Liver; Female; Hepatitis; Hepatocytes; Lipid Peroxides; Methionine; Mice; Mice, Inbred C57BL; PPAR gamma; Protein Kinases; Triglycerides | 2008 |
Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis.
Topics: Animals; Carnitine O-Palmitoyltransferase; Cell Line; Choline Deficiency; Diet; Fatty Acids; Fatty Liver; Interleukin-6; Kupffer Cells; Lipopolysaccharides; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; ortho-Aminobenzoates; Oxidation-Reduction; Oxidative Stress; PPAR alpha; Rats; Rats, Inbred OLETF; RNA, Messenger; Transforming Growth Factor beta; Up-Regulation | 2008 |
Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice.
Topics: Animals; Catalase; Cells, Cultured; Choline Deficiency; Diet; Disease Progression; Enzyme Activation; Fatty Liver; Gene Transfer Techniques; Hepatocytes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha; Reactive Oxygen Species; Receptors, Adiponectin; Signal Transduction; Transforming Growth Factor beta1 | 2008 |
The effects of feeding rats diets deficient in folic acid and related methyl donors on the blood pressure and glucose tolerance of the offspring.
Topics: Acetyl-CoA Carboxylase; Animals; Blood Pressure; Carnitine O-Palmitoyltransferase; Choline Deficiency; Eating; Female; Fetal Development; Fetal Weight; Folic Acid Deficiency; Glucose Tolerance Test; Growth; Insulin; Male; Methionine; Organ Size; Pancreas; Pregnancy; Pregnancy Complications; Prenatal Nutritional Physiological Phenomena; Rats | 2009 |
Alleviative effects of s-allyl cysteine and s-ethyl cysteine on MCD diet-induced hepatotoxicity in mice.
Topics: Animals; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Cholesterol; Choline; Choline Deficiency; Cysteine; Diet; Fatty Acid Synthases; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Interleukin-1beta; Interleukin-6; Liver; Liver Diseases; Malate Dehydrogenase; Male; Malondialdehyde; Methionine; Mice; Mice, Inbred C57BL; Random Allocation; Superoxide Dismutase; Triglycerides; Tumor Necrosis Factor-alpha | 2008 |
Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice.
Topics: Animals; Bile Acids and Salts; Blotting, Western; Choline Deficiency; Coloring Agents; Cytochrome P-450 CYP2E1; Diet; Fatty Acids; Hepatocytes; Lipid Metabolism; Liver Cirrhosis; Liver Function Tests; Liver-Specific Organic Anion Transporter 1; Methionine; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Independent; Oxidative Stress; Retinoid X Receptor alpha; Thiobarbituric Acid Reactive Substances; Up-Regulation | 2009 |
VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice.
Topics: Actins; Animals; Choline Deficiency; Collagen Type I; Diet; Disease Models, Animal; Fatty Liver; Female; Liver Cirrhosis; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Peroxisome Proliferator-Activated Receptors; Probiotics; Signal Transduction; Transforming Growth Factor beta | 2009 |
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase.
Topics: Animals; Apoptosis; Cell Survival; Choline Deficiency; Disease Models, Animal; Fatty Acids; Fatty Liver; Fluorescent Antibody Technique; Hepatocytes; Immunoblotting; Lipids; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Small Interfering; Stearoyl-CoA Desaturase | 2009 |
Utility of a 13C-methacetin breath test in evaluating hepatic injury in rats.
Topics: Acetamides; Administration, Oral; Animals; Breath Tests; Carbon Isotopes; Choline Deficiency; Disease Models, Animal; Fatty Liver; Hepatectomy; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Liver Failure, Acute; Liver Function Tests; Male; Methionine; Organ Size; Predictive Value of Tests; Rats; Rats, Wistar; Severity of Illness Index; Thioacetamide; Time Factors | 2008 |
Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation.
Topics: Adiponectin; AMP-Activated Protein Kinase Kinases; Animals; Choline Deficiency; DNA Primers; Fatty Liver; Female; Inflammation; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pioglitazone; Protein Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sterol Regulatory Element Binding Protein 1; Thiazolidinediones | 2009 |
Choline deprivation induces hyperhomocysteinemia in rats fed low methionine diets.
Topics: Animals; Betaine; Choline; Choline Deficiency; Cysteine; Dietary Supplements; Growth; Homocysteine; Hyperhomocysteinemia; Lipotropic Agents; Liver; Male; Methionine; Rats; Rats, Wistar | 2008 |
Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression.
Topics: Alanine Transaminase; Animals; Apoptosis; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Caspase 3; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; fas Receptor; Fatty Liver; Gene Expression Regulation; Insulin-Like Growth Factor I; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nutritional Status; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Messenger; Time Factors; Tumor Suppressor Protein p53 | 2009 |
Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis.
Topics: Animals; Blood Glucose; Body Weight; Choline Deficiency; Fatty Acids; Fatty Liver; In Situ Nick-End Labeling; Lipid Peroxidation; Lipids; Liver; Male; Methionine; Mice; Polymerase Chain Reaction; Sucrose | 2009 |
Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue.
Topics: Adipocytes; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blood Pressure; Cell Line; Cell Size; Chemokine CCL2; Choline Deficiency; Collagen Type I; Disease Models, Animal; Disease Progression; Drinking; Eating; Fatty Liver; Intra-Abdominal Fat; Liver; Liver Cirrhosis; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Organ Size; Oxidative Stress; Receptors, CCR2; RNA, Messenger; Telmisartan; Transforming Growth Factor beta1; Triglycerides | 2009 |
Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; CpG Islands; Cytosine; Deoxyguanosine; Diet, Reducing; DNA Damage; DNA Methylation; DNA, Neoplasm; Liver Neoplasms, Experimental; Male; Methionine; Rats; Rats, Inbred F344 | 2009 |
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet.
Topics: Animals; Choline Deficiency; Disease Susceptibility; DNA Methylation; Epigenesis, Genetic; Fatty Liver; Folic Acid Deficiency; Histones; Liver; Male; Methionine; Mice; Mice, Inbred Strains; Phenotype; Species Specificity | 2009 |
Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azepines; Chemokine CCL2; Chemokines; Choline Deficiency; Fatty Liver; Hepatitis; Indoles; Lipids; Liver Cirrhosis, Experimental; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Triglycerides | 2009 |
Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats.
Topics: Animals; Apoptosis; Biomarkers; Choline; Choline Deficiency; Cytokines; Diet; Fatty Liver; Glutathione; Histocytochemistry; Liver; Male; Malondialdehyde; Melatonin; Methionine; Oxidative Stress; Rats; Rats, Wistar; Statistics, Nonparametric; Superoxide Dismutase | 2009 |
Children's toxicology from bench to bed--Liver Injury (2): Mechanism of antioxidant therapy for nonalcoholic fatty liver disease.
Topics: alpha-Tocopherol; Animals; Antioxidants; Carrier Proteins; Choline Deficiency; Disease Models, Animal; Fatty Liver; Liver; Male; Methionine; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Vitamin E | 2009 |
MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice.
Topics: Animals; Central Nervous System Depressants; Choline Deficiency; Cytokines; Diet; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; Female; Inflammation; Lipid Metabolism; Liver; Liver Function Tests; Methionine; Mice; Mice, Inbred C57BL; MicroRNAs | 2009 |
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.
Topics: Animals; Case-Control Studies; Cell Line; Cell Transdifferentiation; Choline Deficiency; Disease Progression; Epithelial Cells; Fatty Liver; Fibroblasts; Hedgehog Proteins; Humans; Liver Cirrhosis, Experimental; Methionine; Mice; Mice, Inbred C57BL; Patched Receptors; Patched-1 Receptor; Rats; Receptors, Cell Surface; Recombinant Proteins; RNA, Messenger; Signal Transduction; Veratrum Alkaloids | 2009 |
Progression of lipid peroxidation measured as thiobarbituric acid reactive substances, damage to DNA and histopathological changes in the liver of rats subjected to a methionine-choline-deficient diet.
Topics: Animals; Choline Deficiency; DNA Damage; Lipid Peroxidation; Liver; Male; Methionine; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2009 |
Teucrium polium in prevention of steatohepatitis in rats.
Topics: Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aspartate Aminotransferases; Choline Deficiency; Disease Models, Animal; Fatty Liver; Hepatitis; Lipoproteins; Liver; Male; Methionine; Oxidoreductases; Plant Extracts; Rats; Teucrium | 2009 |
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis.
Topics: Actins; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Choline Deficiency; Diabetes Complications; Disease Models, Animal; Enzyme Inhibitors; Fatty Liver; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Obese; Obesity | 2009 |
Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cells, Cultured; Choline Deficiency; Dietary Supplements; Disease Models, Animal; Fatty Liver; Female; Homocysteine; Liver; Liver Neoplasms; Methionine; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylmethionine; Unfolded Protein Response | 2009 |
Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice.
Topics: Animals; Carrier Proteins; Choline Deficiency; Diet; Fatty Liver; Female; Fibrosis; Hepatitis; Interferon-gamma; Interleukin-1beta; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; NF-kappa B; Oxidative Stress; Thioredoxins; Triglycerides; Tumor Necrosis Factor-alpha | 2009 |
Curcumin limits the fibrogenic evolution of experimental steatohepatitis.
Topics: Actins; Alanine Transaminase; Animals; CD11b Antigen; Cells, Cultured; Chemokine CCL2; Choline; Choline Deficiency; Collagen Type I; Curcumin; Diet; Enzyme Inhibitors; Fatty Liver; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Muscle, Smooth; Oxidative Stress; Reactive Oxygen Species; Tissue Inhibitor of Metalloproteinase-1 | 2010 |
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice.
Topics: Animal Feed; Animals; Choline; Choline Deficiency; Disease Progression; Fatty Liver; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; RNA, Messenger | 2010 |
Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitis.
Topics: Animals; beta Catenin; Bile Acids and Salts; Cholesterol; Choline Deficiency; Diet; Fatty Liver; Genetic Predisposition to Disease; Homeostasis; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Knockout; Organ Specificity; Stress, Physiological | 2010 |
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death.
Topics: Animals; Blood Glucose; Cell Death; Cells, Cultured; Choline Deficiency; Diet; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Fatty Liver; Hepatocytes; Insulin; Methionine; Mice; Mice, Knockout; Molecular Chaperones; Palmitic Acid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factor CHOP; Unfolded Protein Response | 2010 |
[Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats].
Topics: Animals; Apoptosis; Caspases; Cell Proliferation; Choline; Choline Deficiency; Diet; Disease Models, Animal; Endoplasmic Reticulum; Fatty Liver; Liver; Liver Cirrhosis; Male; Methionine; Random Allocation; Rats; Rats, Wistar; RNA, Messenger | 2010 |
Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling.
Topics: Adiponectin; Animals; Apoptosis; Choline Deficiency; Cytokines; Disease Models, Animal; Fatty Liver; Hepatectomy; Hepatocytes; Kupffer Cells; Ligation; Liver Regeneration; Male; Methionine; Portal Vein; PPAR alpha; Preoperative Care; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Adiponectin; RNA, Messenger; Signal Transduction; Technetium Tc 99m Disofenin | 2010 |
[Mechanism of hepatocyte regeneration inhibition in rats with liver fibrosis induced by lipogenic methionine-choline- deficient diet].
Topics: Animals; Apoptosis; Cell Proliferation; Choline Deficiency; Diet; Fatty Liver; Hepatocytes; Liver Cirrhosis; Methionine; Rats | 2009 |
Excretion of glycocyamine by rats on low methionine, low choline diets.
Topics: Animals; Choline; Choline Deficiency; Diet; Glycine; Insulin; Methionine; Rats; Urine | 1947 |
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet.
Topics: Adaptor Proteins, Signal Transducing; Animals; Body Weight; Choline Deficiency; Cytoskeletal Proteins; Disease Models, Animal; Fatty Acids; Fatty Liver; Genotype; Glutathione; Glutathione Transferase; Isoenzymes; Kelch-Like ECH-Associated Protein 1; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Organ Size; Phenotype; RNA, Messenger; Severity of Illness Index; Signal Transduction | 2010 |
Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.
Topics: Alanine Transaminase; Animals; Choline; Choline Deficiency; Diet; Fatty Liver; Genes; Interleukin-6; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha; Receptors, Interleukin-6; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2010 |
PPARgamma is essential for protection against nonalcoholic steatohepatitis.
Topics: Adenoviridae; Animals; Choline Deficiency; Fatty Liver; Gene Transfer Techniques; Genetic Therapy; Methionine; Mice; PPAR gamma; Rosiglitazone; Thiazolidinediones | 2010 |
Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.
Topics: Animals; Choline Deficiency; DNA Methylation; DNA, Neoplasm; Folic Acid Deficiency; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; MicroRNAs | 2010 |
Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Collagen Type I; Dietary Fats; Dietary Fats, Unsaturated; Disease Models, Animal; Fatty Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR gamma; Signal Transduction; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2010 |
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.
Topics: Animals; Choline Deficiency; Fatty Liver; Fibrosis; Hedgehog Proteins; Hepatic Stellate Cells; Humans; Liver; Methionine; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Signal Transduction | 2010 |
Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine-choline-deficient diet.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Blood Glucose; Cholesterol; Choline Deficiency; Diet; Dietary Sucrose; Fatty Liver; Fructose; Gene Expression Profiling; Gene Expression Regulation; Lipid Peroxidation; Lipogenesis; Liver; Male; Methionine; Mice; Mice, Mutant Strains; Reverse Transcriptase Polymerase Chain Reaction; Triglycerides | 2010 |
Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Caspase Inhibitors; Choline Deficiency; Cysteine Proteinase Inhibitors; Dietary Fats; Disease Models, Animal; Fatty Liver; Humans; Male; Methionine; Mice; Mice, Inbred C3H; Mice, Obese; Oxidative Stress | 2010 |
The importance of being choline.
Topics: Brain; Choline; Choline Deficiency; Folic Acid; Humans; Lipotropic Agents; Liver; Methionine; Nootropic Agents; Nutrition Policy; Nutritional Requirements | 2010 |
Stress signaling in the methionine-choline-deficient model of murine fatty liver disease.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 12; Choline Deficiency; Disease Models, Animal; DNA-Binding Proteins; Fatty Liver; Genes, MHC Class II; JNK Mitogen-Activated Protein Kinases; Liver; Male; Methionine; Mice; Mice, Inbred C3H; Oxidative Stress; Regulatory Factor X Transcription Factors; Signal Transduction; Transcription Factors; Triglycerides | 2010 |
Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis.
Topics: Animals; Bile Ducts; Bone Marrow Transplantation; Carbon Tetrachloride Poisoning; Choline Deficiency; Hepatic Stellate Cells; Kupffer Cells; Ligation; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Reactive Oxygen Species; Transplantation Chimera | 2010 |
Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet.
Topics: Animals; Chemokine CCL2; Choline Deficiency; Diet; Fatty Liver; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Transforming Growth Factor beta | 2010 |
Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet.
Topics: Actins; Animals; Choline Deficiency; Connective Tissue Growth Factor; Disease Progression; Eicosapentaenoic Acid; Fatty Liver; Liver; Liver Cirrhosis; Male; Methionine; Non-alcoholic Fatty Liver Disease; Procollagen; Rats; Rats, Wistar; Reactive Oxygen Species; Transforming Growth Factor beta1; Treatment Outcome; Triglycerides | 2011 |
Increased susceptibility to experimental steatohepatitis induced by methionine-choline deficiency in HBs-Tg mice.
Topics: Alanine Transaminase; Animal Feed; Animals; Choline Deficiency; Disease Models, Animal; Disease Susceptibility; Fatty Liver; Hepatitis B Surface Antigens; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proliferating Cell Nuclear Antigen; Statistics, Nonparametric | 2010 |
Extracellular signal-regulated kinases 1/2 suppression aggravates transforming growth factor-beta1 hepatotoxicity: a potential mechanism for liver injury in methionine-choline deficient-diet-fed mice.
Topics: Aldehydes; Animals; Cell Line; Choline Deficiency; Cysteine Proteinase Inhibitors; Enzyme Activation; Epidermal Growth Factor; Humans; Lipid Peroxidation; Liver Diseases; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Rats; Signal Transduction; Transforming Growth Factor beta1 | 2010 |
Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.
Topics: Animals; Cell Line; Choline Deficiency; Diet; Fatty Liver; Hedgehog Proteins; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Osteopontin; Up-Regulation; Veratrum Alkaloids | 2011 |
Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner.
Topics: Animals; Arsenites; Carcinogens; Choline Deficiency; Deoxycytidine; Diet; DNA; DNA Methylation; DNA Modification Methylases; Female; Folic Acid Deficiency; Gene Expression Regulation, Enzymologic; Isoenzymes; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Characteristics; Sodium Compounds | 2011 |
Teucrium polium reversed the MCD diet-induced liver injury in rats.
Topics: Animals; Antioxidants; Caspase 3; Choline Deficiency; Fatty Liver; Gene Expression; Glutathione Peroxidase; Liver; Male; Malondialdehyde; MAP Kinase Kinase 4; Methionine; Plant Extracts; Rats; Rats, Inbred Strains; Superoxide Dismutase; Teucrium; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2011 |
Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis.
Topics: Adipose Tissue; Animals; Choline Deficiency; Diet; Eating; Fatty Acids; Fatty Liver; Gas Chromatography-Mass Spectrometry; Hepatitis; Hepatocytes; Immunohistochemistry; Kinetics; Lipogenesis; Liver; Male; Metabolic Networks and Pathways; Methionine; Mice; Mice, Inbred C57BL; Organ Size; Palmitic Acids; Triglycerides | 2011 |
Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Choline Deficiency; Gene Expression Regulation; Genotype; Hematopoietic Stem Cell Transplantation; Hepatic Stellate Cells; Inflammation Mediators; Lipid Metabolism; Liver; Liver Cirrhosis, Experimental; Liver X Receptors; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Orphan Nuclear Receptors; Phenotype; Signal Transduction | 2011 |
Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Cell Proliferation; Choline Deficiency; Constitutive Androstane Receptor; Disease Models, Animal; Fatty Liver; Genes, myc; Hep G2 Cells; Humans; Ki-67 Antigen; Liver Neoplasms, Experimental; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Pyridines; Receptors, Cytoplasmic and Nuclear | 2011 |
Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice.
Topics: Actins; Alanine Transaminase; Animals; Choline Deficiency; Collagen; Fatty Liver; Female; Genotype; Lipid Peroxidation; Liver; Liver Cirrhosis, Experimental; Lymphocyte Antigen 96; Matrix Metalloproteinase 2; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phenotype; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Tissue Inhibitor of Metalloproteinase-1; Toll-Like Receptor 4; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha | 2011 |
Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by (1) H-magnetic resonance spectroscopy in a rat model.
Topics: Animals; Antioxidants; Choline Deficiency; Chromatography, Gas; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-3; Fatty Liver; Inflammation Mediators; Interleukin-6; Lipid Metabolism; Liver; Magnetic Resonance Spectroscopy; Male; Methionine; Rats; Rats, Wistar; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Induction of heme oxygenase-1 protects against nutritional fibrosing steatohepatitis in mice.
Topics: Actins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Enzyme Induction; Fatty Liver; Heme Oxygenase-1; Hemin; Lipid Peroxides; Liver; Liver Cirrhosis; Male; Malondialdehyde; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Membrane Proteins; Methionine; Mice; Mice, Inbred C57BL; Protoporphyrins; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice.
Topics: Animals; Antibodies, Neutralizing; Apoptosis; Choline Deficiency; Diet; DNA-(Apurinic or Apyrimidinic Site) Lyase; Fatty Liver; Fibrosis; Gene Expression; Hepatocytes; Injections, Intraperitoneal; Interleukin-6; Leptin; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, Interleukin-6; Signal Transduction; STAT3 Transcription Factor | 2011 |
Effect of vitamin K2 on cortical and cancellous bone mass and hepatic lipids in rats with combined methionine-choline deficiency.
Topics: Animals; Body Weight; Bone and Bones; Choline Deficiency; Diaphyses; Femur; Lipid Metabolism; Liver; Male; Methionine; Organ Size; Rats; Rats, Sprague-Dawley; Tibia; Vitamin K 2 | 2011 |
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Biopsy; Choline Deficiency; Cytokines; Disease Models, Animal; Fatty Liver; Female; Humans; Interferon Type I; Liver; Methionine; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Poly I-C; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Double-Stranded | 2011 |
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells.
Topics: Animals; Apoptosis; Caspase 1; Choline Deficiency; Dietary Fats; Disease Models, Animal; Endotoxins; Fatty Acids; Fatty Liver; Female; Hepatocytes; Immune System; Inflammasomes; Interleukin-1beta; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Tumor Necrosis Factor-alpha | 2011 |
Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis.
Topics: Activating Transcription Factor 6; Animal Feed; Animals; Choline; Choline Deficiency; Cytokines; Diabetes Mellitus, Experimental; Eukaryotic Initiation Factor-2; Fatty Liver; Female; JNK Mitogen-Activated Protein Kinases; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Non-alcoholic Fatty Liver Disease; Obesity; Protein Phosphatase 1; Signal Transduction; Transcription Factor CHOP; Unfolded Protein Response | 2011 |
Omega-3 fatty acids reduce hepatic steatosis and consequently attenuate ischemia-reperfusion injury following partial hepatectomy in rats.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Choline Deficiency; Dietary Supplements; Fatty Acids, Monounsaturated; Fatty Acids, Omega-3; Fatty Liver; Hepatectomy; Liver; Male; Methionine; Oxidative Stress; Rats; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2011 |
Pre- and postnatal methyl deficiency in the rat differentially alters glucose homeostasis.
Topics: Animals; Animals, Newborn; Choline Deficiency; Female; Folic Acid Deficiency; Glucose; Growth and Development; Homeostasis; Male; Maternal Nutritional Physiological Phenomena; Methane; Methionine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Lew; Rats, Wistar | 2011 |
Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet.
Topics: Alanine Transaminase; Animals; Bezafibrate; Calcium Channel Blockers; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Hypolipidemic Agents; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Nifedipine; Non-alcoholic Fatty Liver Disease; PPAR gamma; Rats; Rats, Wistar | 2012 |
Decreased accumulation of ultrasound contrast in the liver of nonalcoholic steatohepatitis rat model.
Topics: Animals; Body Weight; Choline Deficiency; Contrast Media; Diet; Disease Models, Animal; Fatty Liver; Kupffer Cells; Leptin; Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Ultrasonography | 2011 |
Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease.
Topics: Animals; Choline Deficiency; Diacylglycerol O-Acyltransferase; DNA-Binding Proteins; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Fatty Acid Synthases; Fatty Acid Transport Proteins; Fatty Acids; Fatty Liver; Fibrosis; Gene Expression; Glycerol-3-Phosphate O-Acyltransferase; Lipid Mobilization; Lipogenesis; Liver; Membrane Proteins; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Phosphorylation; Regulatory Factor X Transcription Factors; Sterol Regulatory Element Binding Protein 1; Transcription Factor CHOP; Transcription Factors | 2011 |
Steatotic liver: a suitable source for the isolation of hepatic progenitor cells.
Topics: Animals; Antigens, Differentiation; Antigens, Neoplasm; Biomarkers; Cell Adhesion Molecules; Cell Separation; Choline Deficiency; Disease Models, Animal; Epithelial Cell Adhesion Molecule; Fatty Liver; Flow Cytometry; Humans; Liver; Male; Methionine; Rats; Stem Cells; Thy-1 Antigens; Time Factors | 2011 |
Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Carnitine; Carnitine O-Palmitoyltransferase; Choline Deficiency; Disease Models, Animal; DNA, Mitochondrial; Fatty Acids, Nonesterified; Fatty Liver; Gene Expression Regulation; Hep G2 Cells; Humans; Liver; Lysosomes; Membrane Potential, Mitochondrial; Methionine; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Stress; PPAR gamma; Rats; Rats, Inbred OLETF; Rats, Long-Evans; RNA, Messenger; Thioctic Acid; Time Factors | 2011 |
A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation.
Topics: Animals; Choline Deficiency; Diet; Disease Models, Animal; DNA-Binding Proteins; Fatty Liver; Feasibility Studies; Gene Expression Regulation; Liver Transplantation; Male; Methionine; Mice; Mice, SCID; Mice, Transgenic; Non-alcoholic Fatty Liver Disease; Phenotype; Tumor Necrosis Factor-alpha | 2012 |
Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis.
Topics: Animals; Anticholesteremic Agents; Azetidines; Bile Acids and Salts; Biliary Tract; Biological Transport; Choline Deficiency; Diet; Ezetimibe; Fatty Liver; Glucuronosyltransferase; Intestinal Mucosa; Liver; Male; Membrane Transport Proteins; Methionine; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2012 |
Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline; Choline Deficiency; Cytochrome P-450 CYP2E1; Diet; Disease Models, Animal; Endoplasmic Reticulum Stress; Fatty Liver; Humans; Inflammation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Thiobarbituric Acid Reactive Substances; Thioctic Acid | 2012 |
Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Antioxidants; Choline Deficiency; Cytokines; Diet; Fatty Liver; Gene Expression; Glutathione; Insulin Resistance; Isoprostanes; JNK Mitogen-Activated Protein Kinases; Liver; Male; Methionine; Mice; Myocardium; Nitrates; Nitrites; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Phosphorylation; Silybin; Silymarin; Statistics, Nonparametric | 2012 |
Pentoxifylline attenuates methionine- and choline-deficient-diet-induced steatohepatitis by suppressing TNF-α expression and endoplasmic reticulum stress.
Topics: Alanine Transaminase; Animals; Cell Line; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fatty Liver; Male; Methionine; Non-alcoholic Fatty Liver Disease; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha; Unfolded Protein Response | 2012 |
Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Choline Deficiency; Cytoskeletal Proteins; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Iron; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Liver; Male; Methionine; Mice; Mice, Knockout; NF-E2-Related Factor 2; Oxidative Stress; Real-Time Polymerase Chain Reaction; Sulfoxides; Thiocyanates | 2012 |
Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress.
Topics: Animals; Ascorbic Acid; Choline Deficiency; Diet; Disease Models, Animal; Ethylenediamines; Fatty Liver; Humans; Lipid Peroxidation; Methionine; Organometallic Compounds; Oxidative Stress; Rats; Salicylates | 2012 |
Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis.
Topics: Actins; Animals; Antigens, Differentiation; Caspase 1; Caspase 3; Choline Deficiency; Clodronic Acid; Collagen Type I; Fatty Liver; Hepatic Stellate Cells; Hepatocytes; Inflammation; Interleukin-1beta; Kupffer Cells; LIM Domain Proteins; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Proteins; Nuclear Proteins; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2012 |
[Mechanism of hepatocyte apoptosis in rats with liver fibrosis induced by lipogenic methionine-choline-deficient diet].
Topics: Animals; Apoptosis; Caspase 12; Caspase 3; Caspase 7; Caspase 9; Choline Deficiency; Diet; Endoplasmic Reticulum Stress; Fatty Liver; Heat-Shock Proteins; Hepatocytes; Liver Cirrhosis; Male; Methionine; Mitogen-Activated Protein Kinases; Non-alcoholic Fatty Liver Disease; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction | 2012 |
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Cholesterol; Choline Deficiency; Diet; Endoplasmic Reticulum; Fatty Liver; Gene Expression; Inflammation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C57BL; Molecular Chaperones; Phenylbutyrates; Real-Time Polymerase Chain Reaction; Stress, Physiological; Taurochenodeoxycholic Acid | 2012 |
Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Choline Deficiency; Disease Models, Animal; Fatty Liver; Homeostasis; Lipid Metabolism; Liver; Male; Methionine; Mice; Mice, Obese; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Silybin; Silymarin; Translational Research, Biomedical | 2012 |
p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.
Topics: Animals; Apoptosis; Caspase 3; Choline Deficiency; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Disease Progression; Fatty Liver; Hepatocytes; Humans; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Primary Cell Culture; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Up-Regulation | 2012 |
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.
Topics: Alanine Transaminase; Animals; Antimycin A; Apoptosis; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Free Radical Scavengers; Glutathione; Hepatocytes; Hydrogen Peroxide; Male; Metalloporphyrins; Methionine; Methionine Adenosyltransferase; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitochondria, Liver; Oxidation-Reduction; Pentanoic Acids; Peroxiredoxin III; Primary Cell Culture; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Thioredoxins | 2012 |
Altered arsenic disposition in experimental nonalcoholic fatty liver disease.
Topics: Animals; Arsenates; Arsenic Trioxide; Arsenicals; Biotransformation; Choline Deficiency; Diet, High-Fat; Disease Models, Animal; Environmental Pollutants; Fatty Liver; Kidney; Liver; Male; Methionine; Methyltransferases; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Non-alcoholic Fatty Liver Disease; Oxides | 2012 |
Intestinal GATA4 deficiency protects from diet-induced hepatic steatosis.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Choline Deficiency; Diet; Disease Models, Animal; Fatty Acids, Nonesterified; Fatty Liver; GATA4 Transcription Factor; Glucagon-Like Peptide 1; Jejunum; Lipid Metabolism; Liver Cirrhosis; Male; Methionine; Mice; Mice, Knockout; Protein Kinases; Sterol Regulatory Element Binding Protein 1; Thiobarbituric Acid Reactive Substances; Triglycerides | 2012 |
Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats.
Topics: Animals; Caseins; Choline; Choline Deficiency; Diet; Glycine; Homocysteine; Hyperhomocysteinemia; Male; Methionine; Rats; Rats, Wistar; Serine | 2012 |
Glycine alleviates liver injury induced by deficiency in methionine and or choline in rats.
Topics: Animals; Antioxidants; Choline Deficiency; Fatty Liver; Glycine; Lipid Metabolism; Lipid Peroxidation; Male; Methionine; Non-alcoholic Fatty Liver Disease; Rats; Rats, Sprague-Dawley | 2012 |
Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Collagen Type I; Collagen Type III; Cyclooxygenase 2; Diet; Disease Models, Animal; Fatty Liver; Fibrosis; HMGB1 Protein; Inflammation; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Quercetin; RNA, Messenger; Smad Proteins; Thiobarbituric Acid Reactive Substances; Toll-Like Receptor 4; Up-Regulation | 2012 |
Prohibitin-1 deficiency promotes inflammation and increases sensitivity to liver injury.
Topics: Animals; Choline Deficiency; Fatty Liver; Inflammation; Male; Methionine; Mice; Prohibitins; Repressor Proteins; Transcriptome | 2012 |
The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Intracellular Signaling Peptides and Proteins; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Real-Time Polymerase Chain Reaction; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha | 2013 |
Dandelion leaf extract protects against liver injury induced by methionine- and choline-deficient diet in mice.
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Humans; Interleukin-6; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Plant Extracts; Plant Leaves; Protective Agents; Taraxacum; Tumor Necrosis Factor-alpha | 2013 |
Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Choline Deficiency; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Fatty Liver; Female; Hepatocytes; In Vitro Techniques; Lipid Metabolism; Liver; Methionine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Neovascularization, Pathologic; Non-alcoholic Fatty Liver Disease; Placenta Growth Factor; Pregnancy Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Diet, Fat-Restricted; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Humans; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred A; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Obesity; Specific Pathogen-Free Organisms; Time Factors | 2013 |
Quercetin decreases liver damage in mice with non-alcoholic steatohepatitis.
Topics: Animals; Antioxidants; Choline Deficiency; Comet Assay; Diet; Disease Models, Animal; DNA Damage; Fatty Liver; Lipid Peroxidation; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred C57BL; Molecular Structure; Oxidative Stress; Quercetin | 2013 |
Metabolic response of normal and malignant tissue to acute and chronic methionine stress in athymic mice bearing human glial tumor xenografts.
Topics: Animals; Brain Neoplasms; Carbon-Sulfur Lyases; Choline; Choline Deficiency; Glioma; Homocysteine; Humans; Liver; Methionine; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2002 |
Influence of dietary methionine level on the liver metallothionein mRNA level in rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Betaine; Blotting, Northern; Body Weight; Choline; Choline Deficiency; Diet; Liver; Male; Metallothionein; Methionine; Organ Size; Rats; Rats, Wistar; RNA, Messenger | 2002 |
Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice.
Topics: Animal Feed; Animals; Anticholesteremic Agents; Choline Deficiency; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Fatty Acids; Fatty Liver; Female; Gene Expression Regulation, Enzymologic; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microsomes; Mixed Function Oxygenases; Pyrimidines; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Severity of Illness Index; Transcription Factors; Triglycerides | 2003 |
Some effects of vitamin B12 in weanling rats consuming hypolipotropic diets.
Topics: Animals; Choline; Choline Deficiency; Corrinoids; Diet; Kidney; Methionine; Rats; Vitamin B 12 | 1953 |
[Experimental data on production of liver cirrhosis induced by dietary choline and methionine deficiencies].
Topics: Animals; Choline; Choline Deficiency; Diet; Liver Cirrhosis; Liver Cirrhosis, Experimental; Methionine | 1957 |
Effect of methionine and choline deficiency on liver choline oxidase activity in young rats.
Topics: Alcohol Oxidoreductases; Animals; Choline; Choline Deficiency; Liver; Methionine; Oxidation-Reduction; Oxidoreductases; Rats | 1963 |
EFFECT OF 3-AMINOPROPANOL ON CHOLINE-DEFICIENCY IN RATS.
Topics: Amino Alcohols; Ammonium Compounds; Choline; Choline Deficiency; Deficiency Diseases; Diet; Kidney; Lipid Metabolism; Liver; Methionine; Pathology; Pharmacology; Phospholipids; Propanolamines; Quaternary Ammonium Compounds; Rats; Research | 1965 |
THE LIPOTROPIC ACTION OF COLD. I. THE INFLUENCE OF COLD AND CHOLINE DEFICIENCY ON LIVER LIPIDS OF RATS AT DIFFERENT INTAKES OF DIETARY METHIONINE.
Topics: Biochemical Phenomena; Biochemistry; Body Weight; Cholesterol; Choline Deficiency; Cold Temperature; Glycerides; Lipid Metabolism; Lipids; Lipotropic Agents; Liver; Metabolism; Methionine; Organ Size; Phospholipids; Rats; Research; Vitamin B Deficiency | 1964 |
THE LIPOTROPIC ACTION OF COLD. 2. THE INFLUENCE OF COLD AND CHOLINE DEFICIENCY ON SERUM LIPIDS OF RATS AT DIFFERENT INTAKES OF DIETARY METHIONINE.
Topics: Cholesterol; Choline; Choline Deficiency; Cold Temperature; Diet; Fatty Liver; Glycerides; Lipids; Lipotropic Agents; Methionine; Phospholipids; Rats; Research; Vitamin B Deficiency | 1965 |
Rodent nutritional model of non-alcoholic steatohepatitis: species, strain and sex difference studies.
Topics: Alanine Transaminase; Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Female; Lipid Peroxidation; Liver; Male; Malnutrition; Methionine; Mice; Mice, Inbred C57BL; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Sex Factors; Species Specificity | 2003 |
The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance.
Topics: Alanine Transaminase; Animals; Blood Glucose; Choline Deficiency; Deficiency Diseases; Fasting; Fatty Liver; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Male; Methionine; Mice; Mice, Inbred Strains | 2004 |
Sex differences in choline-deficient diet-induced steatohepatitis in mice.
Topics: Animal Feed; Animals; Apoptosis; Body Weight; Cell Differentiation; Choline Deficiency; Fatty Liver; Female; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Organ Size; Sex Factors; Transaminases; Triglycerides | 2004 |
Methionine and choline deficiency in the rat with special reference to the pregnant state.
Topics: Animals; Choline; Choline Deficiency; Female; Methionine; Pregnancy; Rats | 1951 |
Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model.
Topics: Alanine Transaminase; Animals; Choline Deficiency; Collagen Type I; Diet; Fatty Liver; Female; Hepatocytes; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred Strains; Mice, Knockout; Molecular Weight; Organ Size; Osteopontin; Oxidative Stress; Sialoglycoproteins; Triglycerides; Tumor Necrosis Factor-alpha; Up-Regulation | 2004 |
Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin.
Topics: Animals; Cell Line; Choline Deficiency; Deficiency Diseases; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Liver; Female; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Osteopontin; Receptors, Cell Surface; Receptors, Leptin; Sialoglycoproteins | 2004 |
Oral glucose tolerance deteriorates in rats fed with methionine choline deficient diet.
Topics: Animals; Choline Deficiency; Deficiency Diseases; Diet; Glucose Tolerance Test; Methionine; Rats | 2004 |
Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice.
Topics: Animals; Cell Adhesion; Choline Deficiency; Deficiency Diseases; Diet; Dietary Fats; Fatty Liver; Fibrosis; Leukocytes; Lipid Metabolism; Lipid Peroxides; Liver; Liver Circulation; Macrophages; Male; Methionine; Mice; Mice, Inbred C57BL; Microcirculation; Microscopy, Electron; Oxidative Stress; Phagocytes; Vascular Patency | 2004 |
Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet.
Topics: Alanine Transaminase; Animals; Choline Deficiency; Deficiency Diseases; Diet; Disease Progression; Fatty Liver; Female; Glutathione; Hepatitis; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Pentoxifylline; Phosphodiesterase Inhibitors; RNA, Messenger; Triglycerides; Tumor Necrosis Factor-alpha | 2004 |
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice.
Topics: Animals; Chemokine CCL2; Choline Deficiency; Collagen Type I; Curcumin; Cyclooxygenase 2; Deficiency Diseases; Diet; Enzyme Inhibitors; Fatty Liver; Female; Hepatitis; Inflammation Mediators; Intercellular Adhesion Molecule-1; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Severity of Illness Index; Transcription Factor AP-1 | 2004 |
Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Choline Deficiency; Cytochrome P-450 CYP2E1; Diet; Fatty Liver; Male; Methionine; Mice; Mice, Transgenic; Prealbumin | 2005 |
Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice.
Topics: Animals; Apoptosis; Cell Adhesion Molecules; Choline Deficiency; Fatty Liver; Gene Expression Regulation; Kupffer Cells; Liver Cirrhosis, Experimental; Male; Methionine; Mice; Mice, Knockout; Mitochondria, Liver; Mutation; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha | 2006 |
NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis.
Topics: Animals; Choline; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Inflammation Mediators; Intercellular Adhesion Molecule-1; Methionine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; NF-kappa B; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Tumor Necrosis Factor-alpha | 2005 |
JNK1 but not JNK2 promotes the development of steatohepatitis in mice.
Topics: Adiponectin; Alanine Transaminase; Animals; Apoptosis; Choline Deficiency; Enzyme Activation; Fatty Liver; Female; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Triglycerides | 2006 |
Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium.
Topics: Animals; Cell Line; Choline Deficiency; Culture Media; Fatty Liver; Hepatocytes; Methionine; Mice; Osteopontin; Phosphatidylinositol 3-Kinases; Sialoglycoproteins; Transaminases | 2006 |
COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator.
Topics: Animals; Choline Deficiency; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diet; Enzyme Induction; Fatty Liver; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-6; Lipogenesis; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; PPAR alpha; Tumor Necrosis Factor-alpha | 2006 |
A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.
Topics: Animals; Choline Deficiency; Diet; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Folic Acid Deficiency; Gene Silencing; Liver; Liver Neoplasms; Male; Methionine; Rats; Rats, Inbred F344; Transcription Factors | 2006 |
Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency.
Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Fatty Liver; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Rats; Triglycerides; Tumor Necrosis Factor-alpha | 2006 |
Distinct effects of folate and choline deficiency on plasma kinetics of methionine and homocysteine in rats.
Topics: Animals; Choline Deficiency; Folic Acid Deficiency; Homocysteine; Kinetics; Male; Methionine; Methylation; Rats; Rats, Sprague-Dawley | 2006 |
Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1.
Topics: Animals; Cells, Cultured; Choline Deficiency; Diet; Lipogenesis; Liver; Male; Methionine; Mice; Nutrition Disorders; Stearoyl-CoA Desaturase | 2006 |
Downregulation of miR-122 in the rodent and human hepatocellular carcinomas.
Topics: Animals; Carcinoma, Hepatocellular; Choline Deficiency; Diet; Folic Acid Deficiency; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Methionine; Microarray Analysis; MicroRNAs; Rats; Rats, Inbred F344 | 2006 |
The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Constitutive Androstane Receptor; Diet; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Knockout; Organ Size; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Translocation, Genetic | 2007 |
Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Methionine; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Quantitative Trait Loci | 2006 |
Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease.
Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Fatty Liver; Female; Hydroxyproline; Iron Overload; Lipid Peroxidation; Liver; Methionine; Organ Size; Rats; Rats, Inbred F344 | 2006 |
NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis.
Topics: Animals; Chemokine CCL2; Chemokine CCL4; Choline; Choline Deficiency; Cyclooxygenase 2; Diet; Disease Models, Animal; Fatty Liver; Female; Gene Expression Regulation; Hepatitis; Intercellular Adhesion Molecule-1; Liver; Macrophage Inflammatory Proteins; Membrane Glycoproteins; Methionine; Mice; Mice, Mutant Strains; NADPH Oxidase 2; NADPH Oxidases; NF-kappa B; Oxidative Stress; RNA, Messenger; Tumor Necrosis Factor-alpha | 2007 |
Choline cannot be replaced by propanolamine in mice.
Topics: Animals; Choline; Choline Deficiency; Fatty Liver; Liver; Methionine; Mice; Mice, Inbred C57BL; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Propanolamines; Triglycerides | 2007 |
Yo jyo hen shi ko, a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet.
Topics: Animals; Biomarkers; Body Weight; Choline Deficiency; Diet; Dietary Fats; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fatty Liver; Hepatitis; Lipids; Liver; Male; Methionine; Mice; Mice, Obese; Oxidative Stress; Transaminases | 2007 |
Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis.
Topics: Animals; Benzamides; Cholesterol; Choline Deficiency; Cyclooxygenase 2; Diet; Enzyme Activation; Fatty Liver; Gene Expression; Hypolipidemic Agents; Intercellular Adhesion Molecule-1; Interleukin-6; Lipogenesis; Lipoprotein Lipase; Lipoproteins, HDL; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Organophosphorus Compounds; PPAR gamma; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Tumor Necrosis Factor-alpha | 2007 |
Protective effect of soy isoflavones and activity levels of plasma paraoxonase and arylesterase in the experimental nonalcoholic steatohepatitis model.
Topics: Animals; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Choline Deficiency; Disease Models, Animal; Fatty Liver; Glycine max; Hepatitis; Isoflavones; Lipid Peroxidation; Liver; Male; Malondialdehyde; Methionine; Rats | 2007 |
CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis.
Topics: Acute-Phase Reaction; Animals; Body Weight; CCAAT-Enhancer-Binding Protein-beta; Choline Deficiency; Cytochrome P-450 CYP2E1; Diet; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum; Eukaryotic Initiation Factor-2; Fatty Liver; Inflammation; JNK Mitogen-Activated Protein Kinases; Lipase; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; NF-kappa B; Transcription Factor CHOP; Tumor Necrosis Factor-alpha | 2007 |
Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline; Choline Deficiency; Diet; Fatty Acids, Unsaturated; Fatty Liver; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C3H | 2007 |
Role of adipocytokines in hepatic fibrogenesis.
Topics: Adiponectin; Animals; Choline Deficiency; Disease Models, Animal; Disease Progression; Fatty Liver; Kupffer Cells; Leptin; Liver; Liver Cirrhosis; Methionine; Mice; Mice, Inbred C57BL; Oxidative Stress; Transforming Growth Factor beta1; Up-Regulation | 2007 |
Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis.
Topics: Animals; Choline Deficiency; Clodronic Acid; Collagen Type I; Collagen Type I, alpha 1 Chain; Diet; Endotoxemia; Fatty Liver; Hepatitis, Animal; Kupffer Cells; Lymphotoxin-alpha; Methionine; Mice; Mice, Mutant Strains; PPAR alpha; Signal Transduction; Toll-Like Receptor 4; Triglycerides | 2007 |
Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.
Topics: Adult; Aged; Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Clorgyline; Disease Models, Animal; Fatty Liver; Female; Hepatitis; Humans; Lipid Peroxidation; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Severity of Illness Index; Tryptophan Hydroxylase; Up-Regulation | 2007 |
Disruption of lipid metabolism in the liver of the pregnant rat fed folate-deficient and methyl donor-deficient diets.
Topics: Animals; Choline Deficiency; Diet; Down-Regulation; Female; Folic Acid Deficiency; Lipid Metabolism; Liver; Methionine; Pregnancy; Prenatal Nutritional Physiological Phenomena; Protein Biosynthesis; Proteomics; Rats; RNA, Messenger; Triglycerides; Up-Regulation; Weight Gain | 2008 |
Methionine deficiency and hepatic injury in a dietary steatohepatitis model.
Topics: Animals; Choline Deficiency; Fatty Liver; Gene Expression; Hepatitis, Animal; Liver; Male; Methionine; Rats; Rats, Sprague-Dawley | 2008 |
Not all models of fatty liver are created equal: understanding mechanisms of steatosis development is important.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Fatty Liver, Alcoholic; Humans; Methionine; Rats | 2007 |
Essential pathogenic and metabolic differences in steatosis induced by choline or methione-choline deficient diets in a rat model.
Topics: Animals; Choline Deficiency; Disease Models, Animal; Fatty Liver; Insulin; Lipids; Liver; Male; Methionine; Oxidative Stress; Rats; Rats, Wistar | 2007 |
Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis.
Topics: Animal Feed; Animals; Antioxidants; Catalytic Domain; Choline Deficiency; Diet; Disease Models, Animal; Epoxide Hydrolases; Fatty Liver; Glutamate-Cysteine Ligase; Heme Oxygenase (Decyclizing); Male; Methionine; NAD(P)H Dehydrogenase (Quinone); Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Up-Regulation | 2007 |
Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation.
Topics: Animals; Choline Deficiency; Dietary Fats, Unsaturated; Disease Models, Animal; Down-Regulation; Fatty Acids; Fatty Acids, Omega-3; Fatty Liver; Female; Fish Oils; Gene Expression; Lipid Peroxides; Lipogenesis; Lipolysis; Liver; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha | 2008 |
Interstrain differences in susceptibility to non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Body Weight; Choline Deficiency; Disease Models, Animal; Disease Susceptibility; Fatty Liver; Gene Expression; Lipid Metabolism; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Methionine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Organ Size; RNA, Messenger; Species Specificity | 2008 |
Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse.
Topics: Animals; Apoptosis; Choline Deficiency; Constitutive Androstane Receptor; Fatty Acids; Fatty Liver; Inflammation; Leukotriene B4; Methionine; Mice; Mice, Inbred C57BL; PPAR alpha; Pyridines; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2007 |
Mitochondrial adaptations to steatohepatitis induced by a methionine- and choline-deficient diet.
Topics: Adaptation, Physiological; Animal Feed; Animals; Choline; Choline Deficiency; Energy Metabolism; Fatty Liver; Hepatitis; Interleukin-6; Male; Malnutrition; Methionine; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2008 |
The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury.
Topics: Animals; Body Weight; Choline Deficiency; Diet; Ethanol; Fatty Liver; Fatty Liver, Alcoholic; Gene Expression; Liver; Liver Function Tests; Male; Methionine; Mice; Mice, Inbred Strains; Organ Size; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet.
Topics: Actins; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Aspartate Aminotransferases; Choline Deficiency; Diet; Disease Models, Animal; Fatty Liver; Hepatitis; Infliximab; Injections, Intraperitoneal; Liver; Liver Cirrhosis; Male; Malondialdehyde; Methionine; Necrosis; Rats; Time Factors; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2008 |
Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo.
Topics: Animals; Capsules; Cells, Cultured; Choline Deficiency; Fatty Liver; Flavonoids; Glucosides; Hepatocytes; Herbal Medicine; Hydrolyzable Tannins; Male; Methionine; Mice; Mice, Inbred C57BL; Phyllanthus; Polysaccharides; Rats; Rats, Wistar | 2008 |
Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet.
Topics: Adipose Tissue; Animals; Body Weight; Choline Deficiency; Chromatography, Liquid; Dietary Fats; Fatty Liver; Lipids; Lipoproteins, VLDL; Liver; Methionine; Mice; Models, Biological; Organ Size; Polymerase Chain Reaction; RNA; Skin; Viscera | 2008 |
Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Body Weight; Carnosine; Choline Deficiency; Collagen Type I; Collagen Type I, alpha 1 Chain; Disease Models, Animal; Fatty Liver; Gene Expression Regulation; Hepatic Stellate Cells; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Methionine; Mice; Mice, Inbred C57BL; Organometallic Compounds; RNA, Messenger; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Transforming Growth Factor beta1; Triglycerides; Tumor Necrosis Factor-alpha; Zinc Compounds | 2008 |
A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate.
Topics: Animal Feed; Animals; Body Weight; Choline Deficiency; Chromatin Immunoprecipitation; DNA Methylation; Epigenesis, Genetic; Genomic Imprinting; Histones; Insulin-Like Growth Factor II; Male; Methionine; Mice; Mice, Congenic; Mice, Inbred C57BL; Organ Size; Polymorphism, Genetic; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms; RNA, Long Noncoding; RNA, Untranslated; Seminal Vesicles | 2008 |
Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Choline Deficiency; Disease Models, Animal; Fatty Acids; Fatty Liver; Imidazoles; Insulin Resistance; Liver Cirrhosis, Experimental; Male; Methionine; Oxidative Stress; Rats; Rats, Long-Evans; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Tetrazoles; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2008 |
Effect of vitamin B-12 in choline deficiency in the rat.
Topics: Amino Acids; Animals; Body Weight; Choline; Choline Deficiency; Diet; FIGLU Test; Folic Acid; Growth; Hematocrit; Hemoglobins; Kidney; Lipid Metabolism; Liver; Male; Methionine; Organ Size; Rats; Vitamin B 12; Vitamin B Deficiency | 1967 |
Carnitine depletion in the choline-deficient state.
Topics: Animal Nutritional Physiological Phenomena; Animals; Carbon Isotopes; Carnitine; Choline; Choline Deficiency; Depression, Chemical; Diet; Fatty Acids; Female; Liver; Methionine; Myocardium; Oxidation-Reduction; Phosphatidylcholines; Puromycin; Rats; Stimulation, Chemical | 1967 |
Lipotropes, immunocompetence, and cancer.
Topics: Animals; Choline Deficiency; Disease Susceptibility; Folic Acid Deficiency; Immunocompetence; Lipotropic Agents; Methionine; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasms; Rats; Rats, Inbred F344; Rats, Inbred Strains; Vitamin B 12 Deficiency | 1983 |
Effect of diet on choline phosphotransferase, phosphatidylethanolamine methyltransferase and phosphatidyldimethylethanolamine methyltransferase in liver microsomes.
Topics: Animals; Choline; Choline Deficiency; Diacylglycerol Cholinephosphotransferase; Diet; Female; Methionine; Methyltransferases; Microsomes, Liver; Phosphatidyl-N-Methylethanolamine N-Methyltransferase; Phosphatidylethanolamine N-Methyltransferase; Phosphotransferases; Rats | 1980 |
Effects of a methyl-deficient diet on rat liver phosphatidylcholine biosynthesis.
Topics: Animals; Choline Deficiency; Diacylglycerol Cholinephosphotransferase; Diet; Female; Liver; Methionine; Methylation; Methyltransferases; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
The induction of resistant hepatocytes during initiation of liver carcinogenesis with chemicals in rats fed a choline deficient methionine low diet.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Choline Deficiency; Dimethylhydrazines; Hepatectomy; Liver Neoplasms, Experimental; Male; Methionine; Rats; Rats, Inbred F344 | 1983 |
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens.
Topics: Animals; Choline Deficiency; DNA; Liver Neoplasms, Experimental; Male; Methionine; Methylation; Phenobarbital; Rats; Rats, Inbred F344 | 1984 |
Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine.
Topics: Animals; Cell Nucleus; Choline Deficiency; Free Radicals; Lipid Peroxides; Liver; Liver Neoplasms; Male; Methionine; Rats; Rats, Inbred F344 | 1984 |
The rapid induction of liver cell death in rats fed a choline-deficient methionine-low diet.
Topics: Animals; Cell Division; Cell Survival; Choline Deficiency; DNA; L-Iditol 2-Dehydrogenase; Liver; Liver Regeneration; Male; Methionine; Rats; Rats, Inbred F344 | 1983 |
Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet.
Topics: Animals; Cell Nucleus; Choline Deficiency; Deoxycytidine; Diet; Diethylnitrosamine; DNA; Liver; Liver Neoplasms; Male; Methionine; Methylation; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Alterations in immune function in rats caused by dietary lipotrope deficiency: effect of age.
Topics: Aging; Animals; Cells, Cultured; Choline Deficiency; Folic Acid Deficiency; Immunocompetence; Lymph Nodes; Lymphocyte Activation; Male; Methionine; Rats; Rats, Inbred Strains; Salmonella Infections; Salmonella typhimurium; Spleen; Thymus Gland | 1982 |
Importance of serine formation and choline supply in methionine methyl carbon oxidation in the rat.
Topics: Animals; Carbon Dioxide; Choline; Choline Deficiency; Diet; Liver; Male; Methionine; Rats; Serine | 1981 |
Tissue distribution of methylcobalamin in rats fed amino acid-defined, methyl-deficient diets.
Topics: Adrenal Glands; Amino Acids; Animals; Choline Deficiency; Diet; Kidney; Liver; Male; Methionine; Rats; Rats, Inbred F344; Spleen; Tissue Distribution; Vitamin B 12; Vitamin B 12 Deficiency | 1983 |
Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks.
Topics: Animals; Body Weight; Choline Deficiency; Diet; Folic Acid Deficiency; Homocysteine; Kinetics; Liver; Lung; Male; Methionine; Methylation; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine; Testis; Tissue Distribution; Vitamin B 12 Deficiency | 1983 |
Ethanol and diet interactions in male rhesus monkeys.
Topics: Animals; Body Weight; Choline Deficiency; Deficiency Diseases; Fatty Liver, Alcoholic; Folic Acid Deficiency; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoholic; Macaca mulatta; Male; Methionine | 1981 |
Methotrexate effects on hepatic betaine levels in choline-supplemented and choline-deficient rats.
Topics: Aging; Animals; Betaine; Choline; Choline Deficiency; Liver; Male; Methionine; Methotrexate; Rats; Rats, Inbred Strains | 1982 |
Influence of dietary protein and excess methionine on choline needs for young bobwhite quail.
Topics: Animals; Body Weight; Choline; Choline Deficiency; Colinus; Dietary Proteins; Female; Male; Methionine; Nutritional Requirements; Poultry Diseases; Quail | 1982 |
Alterations in immune function in rats caused by dietary lipotrope deficiency: effect of culture medium, 2-mercaptoethanol and mitogen dose on the in vitro lymphocyte transformation response.
Topics: Animals; Cells, Cultured; Choline Deficiency; Concanavalin A; Culture Media; Dose-Response Relationship, Drug; Folic Acid Deficiency; Lymph Nodes; Lymphocyte Activation; Male; Mercaptoethanol; Methionine; Rats; Rats, Inbred Strains; Spleen; Thymidine; Thymus Gland | 1982 |
An inverse correlation between hepatic ornithine decarboxylase and S-adenosylmethionine in rats.
Topics: Animals; Carboxy-Lyases; Cell Division; Choline Deficiency; Diet; Liver; Male; Methionine; Ornithine Decarboxylase; Rats; Rats, Inbred F344; S-Adenosylmethionine | 1981 |
Comparative effects of S-methylmethionine (vitamin U) and methionine on choline-deficient fatty liver in rats.
Topics: Animals; Body Weight; Choline Deficiency; Diet; Fatty Liver; Male; Methionine; Organ Size; Rats; Time Factors; Vitamin U; Vitamins | 1980 |
Influence of dietary lipotrope and lipid content on aflatoxin B1, N-2-fluorenylacetamide, and 1,2-dimethylhydrazine carcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Aflatoxins; Animals; Choline; Choline Deficiency; Diet; Dietary Fats; Dimethylhydrazines; Gastrointestinal Neoplasms; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methionine; Neoplasms, Experimental; Rats | 1980 |
Choline/methionine nutrition of starting broiler chicks. Three models for estimating the choline requirement with economic considerations.
Topics: Animal Nutritional Physiological Phenomena; Animals; Chickens; Choline; Choline Deficiency; Diet; Methionine | 1980 |
Nicotinamide megadosing increases hepatic poly(ADP-ribose) levels in choline-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Choline; Choline Deficiency; Disease Models, Animal; Dose-Response Relationship, Drug; Food, Fortified; Liver; Male; Methionine; NAD; Niacinamide; Poly Adenosine Diphosphate Ribose; Random Allocation; Rats; Rats, Inbred F344 | 1995 |
Modulation of expression of fos and Ha-ras oncogenes and ornithine decarboxylase activity in mammary gland and liver of young female rats by the absence of dietary lipotropes.
Topics: Animals; Choline; Choline Deficiency; Diet; Female; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation; Genes, fos; Genes, ras; Liver; Mammary Glands, Animal; Methionine; Ornithine Decarboxylase; Rats; Rats, Sprague-Dawley; Vitamin B 12 Deficiency | 1994 |
On the role of compensatory mitogenesis in the hepatocarcinogenicity of choline and multiple-lipotrope devoid diets.
Topics: Animals; Body Weight; Cell Death; Cell Division; Choline Deficiency; Female; Lipid Metabolism; Liver; Liver Neoplasms, Experimental; Methionine; Rats; Rats, Inbred F344 | 1994 |
Choline deficiency in cultured adrenal medullary cells: effect on phosphatidylcholine biosynthesis.
Topics: Adrenal Medulla; Animals; Caproates; Cattle; Cells, Cultured; Choline Deficiency; Methionine; Methylation; Phosphatidylcholines; Phosphatidylethanolamines | 1994 |
In vivo microscopic observation of fatty liver grafts after reperfusion.
Topics: Animals; Choline Deficiency; Endothelium, Vascular; Fatty Liver; Graft Survival; Liver; Liver Circulation; Liver Transplantation; Methionine; Microcirculation; Organ Preservation; Rats; Rats, Inbred ACI; Reperfusion; Time Factors; Transplantation, Isogeneic | 1994 |
A rat fatty liver transplant model.
Topics: Animals; Choline Deficiency; Chromatography, Gas; Diet; Disease Models, Animal; Fatty Liver; Graft Survival; Lipids; Liver; Liver Diseases; Liver Transplantation; Male; Methionine; Necrosis; Postoperative Period; Rats; Rats, Inbred ACI; Time Factors | 1993 |
Ethynylestradiol protection against methyl insufficiency in castrated male Wistar/Furth rats fed a methionine-choline-deficient diet.
Topics: Animals; Body Weight; Castration; Choline Deficiency; Ethinyl Estradiol; Liver; Lung; Male; Methionine; Organ Size; Pancreas; Rats; Rats, Inbred WF; S-Adenosylhomocysteine; S-Adenosylmethionine | 1993 |
Inhibition by acetylsalicylic acid, a cyclo-oxygenase inhibitor, and p-bromophenacylbromide, a phospholipase A2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
Topics: Acetophenones; Animals; Aspirin; Choline; Choline Deficiency; Cyclooxygenase Inhibitors; Fatty Liver; gamma-Glutamyltransferase; Glutathione Transferase; Lipoxygenase Inhibitors; Liver; Liver Cirrhosis, Experimental; Liver Neoplasms, Experimental; Male; Masoprocol; Methionine; Oxidative Stress; Phospholipases A; Phospholipases A2; Precancerous Conditions; Quercetin; Rats; Rats, Inbred F344; Time Factors | 1996 |
Prevention by methionine of enhancement of hepatocarcinogenesis by coadministration of a choline-deficient L-amino acid-defined diet and ethionine in rats.
Topics: Amino Acids; Animals; Carcinogens; Choline Deficiency; Cocarcinogenesis; DNA Damage; Ethionine; Food, Formulated; Gene Expression Regulation; Guanine; Liver; Liver Neoplasms, Experimental; Male; Methionine; Oncogenes; Oxidative Stress; Rats; Rats, Inbred F344; Thiobarbituric Acid Reactive Substances | 1995 |
Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.
Topics: Animals; Carcinogens; Cell Division; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver Neoplasms, Experimental; Male; Methionine; Methylation; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Phenobarbital | 1996 |
Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia.
Topics: Animals; Carotid Arteries; Choline Deficiency; Cross-Over Studies; Diet; Extremities; Folic Acid Deficiency; Homocysteine; Homocystine; Macaca fascicularis; Methionine; Protein C; Random Allocation; Regional Blood Flow; Thrombomodulin; Vascular Diseases; Vascular Resistance; Vasomotor System | 1996 |
Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity.
Topics: Animals; Body Weight; Choline Deficiency; Diet; Liver Neoplasms, Experimental; Male; Methionine; NAD; Niacin; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred F344; Tetrahydrofolates | 1997 |
The effects of N-acetylcysteine and anti-intercellular adhesion molecule-1 monoclonal antibody against ischemia-reperfusion injury of the rat steatotic liver produced by a choline-methionine-deficient diet.
Topics: Acetylcysteine; Acid Phosphatase; Alanine Transaminase; Animals; Antibodies, Monoclonal; Aspartate Aminotransferases; Bile; Choline Deficiency; Fatty Liver; In Vitro Techniques; Intercellular Adhesion Molecule-1; Ischemia; L-Lactate Dehydrogenase; Liver; Male; Malondialdehyde; Methionine; Microscopy, Electron; Neutrophils; Perfusion; Rats; Rats, Wistar; Reperfusion Injury | 1997 |
Vitamins C, E and A and heme oxygenase in rats fed methyl/folate-deficient diets.
Topics: Animals; Ascorbic Acid; Carcinoma, Hepatocellular; Choline Deficiency; Folic Acid Deficiency; Heme Oxygenase (Decyclizing); Liver Neoplasms; Male; Methionine; Niacin; Oxidative Stress; Rats; Rats, Inbred F344; Vitamin A; Vitamin E; Vitamin E Deficiency; Vitamins; Weight Gain | 1997 |
Augmentation of mitochondrial reduced glutathione by S-adenosyl-L-methionine administration in ischemia-reperfusion injury of the rat steatotic liver induced by choline-methionine-deficient diet.
Topics: Animals; Choline Deficiency; Glutathione; Glutathione Disulfide; Ischemia; Liver; Male; Methionine; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Wistar; Reperfusion Injury; S-Adenosylmethionine | 1998 |
S-adenosylmethionine deficiency and TNF-alpha in lipopolysaccharide-induced hepatic injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Choline Deficiency; Glutathione; Lipopolysaccharides; Liver; Male; Methionine; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Tumor Necrosis Factor-alpha | 1998 |
Ability of endogenous folate from soy protein isolate to maintain plasma homocysteine and hepatic DNA methylation during methyl group depletion in rats.
Topics: 5-Methylcytosine; Animals; Caseins; Choline Deficiency; Cytosine; Dietary Proteins; DNA; DNA Methylation; Folic Acid; Folic Acid Deficiency; Homocysteine; Liver; Male; Methionine; Rats; Rats, Sprague-Dawley; Soybean Proteins; Weaning | 1998 |
Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets.
Topics: Animals; Choline Deficiency; Diet; DNA Methylation; DNA Modification Methylases; Gene Expression; Liver Neoplasms, Experimental; Male; Methionine; Rats; Rats, Inbred F344; Substrate Specificity | 1998 |
S-adenosyl-L-methionine attenuates ischemia-reperfusion injury of steatotic livers.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Choline Deficiency; Fatty Liver; Glutathione; Glutathione Disulfide; Ischemia; L-Lactate Dehydrogenase; Liver; Male; Methionine; Mitochondria, Liver; Rats; Rats, Wistar; Reperfusion Injury; S-Adenosylmethionine | 1998 |
N-acetylcysteine and anti-ICAM-1 monoclonal antibody reduce ischemia-reperfusion injury of the steatotic rat liver.
Topics: Acetylcysteine; Adenosine; Allopurinol; Animals; Antibodies, Monoclonal; Choline Deficiency; Fatty Liver; Glutathione; Insulin; Intercellular Adhesion Molecule-1; Ischemia; Liver; Male; Methionine; Organ Preservation; Organ Preservation Solutions; Raffinose; Rats; Rats, Wistar; Reperfusion Injury | 1998 |
Does steatohepatitis impair liver regeneration? A study in a dietary model of non-alcoholic steatohepatitis in rats.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Choline Deficiency; Fatty Liver; Follow-Up Studies; Hepatectomy; Hepatitis, Animal; Liver Regeneration; Male; Methionine; Rats; Rats, Wistar | 1999 |
Single versus multiple deficiencies of methionine, zinc, riboflavin, vitamin B-6 and choline elicit surprising growth responses in young chicks.
Topics: Animals; Animals, Newborn; Chickens; Choline Deficiency; Male; Methionine; Pyridoxine; Riboflavin Deficiency; Vitamin B 6 Deficiency; Zinc | 1999 |
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
Topics: Animals; Catalysis; Choline Deficiency; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Fatty Liver; Female; Gene Expression; Hepatitis; Lipid Peroxidation; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microsomes; Mixed Function Oxygenases; Weight Loss | 2000 |
DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats.
Topics: Animals; Choline Deficiency; Colon; Colonic Neoplasms; Comet Assay; DNA; DNA Damage; DNA Methylation; Folic Acid; Folic Acid Deficiency; Liver; Male; Methionine; Rats; S-Adenosylmethionine; Vitamin B 12 | 2000 |
Increased uracil misincorporation in lymphocytes from folate-deficient rats.
Topics: Animals; Choline Deficiency; Comet Assay; DNA; DNA Damage; Erythrocytes; Folic Acid; Folic Acid Deficiency; Liver; Lymphocytes; Male; Methionine; Rats; Uracil; Vitamin B 12 | 2000 |
Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice.
Topics: Animals; Biomarkers; Choline Deficiency; Diet; DNA Methylation; Folic Acid Deficiency; Intestinal Neoplasms; Methionine; Mice; Neoplasms; Precancerous Conditions; S-Adenosylhomocysteine; S-Adenosylmethionine | 2002 |
Interaction of methotrexate with lipotropic factors in rat liver.
Topics: Animals; Cholesterol; Choline; Choline Deficiency; Diet; Drug Synergism; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Phospholipids; Rats; Triglycerides; Vitamin B 12 | 1975 |
Beneficial effects of L-methionine in choline deficient diets of Oryzaephilus mercator (Fauvel) (Coleoptera).
Topics: Animals; Choline Deficiency; Coleoptera; Methionine | 1975 |
The effects of a marginally lipotrope-deficient diet on the hepatic levels of S-adenosylmethionine and on the urinary metabolites of 2-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Benzopyrene Hydroxylase; Choline Deficiency; Diet; Female; Fluorenes; Folic Acid Deficiency; Glutathione; Hydroxyacetylaminofluorene; Lipotropic Agents; Liver; Male; Methionine; Microsomes, Liver; Nitroanisole O-Demethylase; Rats; S-Adenosylmethionine; Sex Factors | 1977 |
Effects of early marginal methionine-choline deprivation on the development of the immune system in the rat.
Topics: Agglutination Tests; Aging; Animals; Antibody Formation; Choline Deficiency; Female; Hypersensitivity, Delayed; Immunity, Cellular; Lactation; Lymphocytes; Male; Maternal-Fetal Exchange; Methionine; Mitogens; Pregnancy; Pregnancy Complications; Rats; Salmonella Infections; Salmonella typhimurium | 1979 |
Alterations in the chain length of pteroylpoly-gamma-glutamates and in the activity of pteroylpoly-gamma-glutamate hydrolase in response to changes in the steady state of one carbon metabolism.
Topics: Animals; Carboxypeptidases; Caseins; Choline Deficiency; Coturnix; Dietary Proteins; Folic Acid; gamma-Glutamyl Hydrolase; Glutamates; Liver; Male; Methionine; Quail | 1977 |
Effect of choline deficiency on utilization of labeled precursors of choline and turnover of choline in the liver of mature Japanese quail.
Topics: Animal Nutritional Physiological Phenomena; Animals; Chickens; Choline; Choline Deficiency; Coturnix; Ethanolamines; Liver; Methionine; Phospholipids; Rats | 1975 |
Determination of carnitine turnover in choline-deficient and cold-exposed rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Composition; Body Weight; Carbon Radioisotopes; Carnitine; Choline; Choline Deficiency; Cold Temperature; Dietary Fats; Feces; Half-Life; Male; Methionine; Rats; Time Factors | 1975 |
Effect of low methionine, choline deficient diets upon major unsaturated phosphatidyl choline fractions of rat liver and plasma.
Topics: Animals; Choline; Choline Deficiency; Chromatography, Thin Layer; Diet; Liver; Male; Methionine; Phosphatidylcholines; Rats; Time Factors | 1975 |
Acute hemorrhagic pancreatic necrosis in mice. Influence of the age and sex of the animals and of dietary ethionine, choline, methionine, and adenine sulfate.
Topics: Acute Disease; Adenine; Age Factors; Animals; Choline; Choline Deficiency; Diet; Ethionine; Female; Hemorrhage; Male; Methionine; Mice; Necrosis; Pancreatic Diseases; Sex Factors | 1975 |
Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid.
Topics: Animals; Choline; Choline Deficiency; Chromatography, High Pressure Liquid; Diet; Folic Acid; Folic Acid Deficiency; Male; Methionine; Nucleotides; Rats; Rats, Inbred F344; Spleen | 1992 |
Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Biotransformation; Choline Deficiency; Diet; DNA; DNA Repair; Liver; Liver Neoplasms; Liver Regeneration; Male; Methionine; Precancerous Conditions; Rats; Rats, Inbred F344 | 1992 |
Evidence that the rate of phosphatidylcholine catabolism is regulated in cultured rat hepatocytes.
Topics: Animals; Cells, Cultured; Choline; Choline Deficiency; Glycerylphosphorylcholine; Kinetics; Liver; Male; Methionine; Microsomes, Liver; Mitochondria, Liver; Phosphatidylcholines; Phospholipases A; Rats; Rats, Inbred Strains; Solubility | 1991 |
Head group specificity in the regulation of phosphatidylcholine catabolism in rat hepatocytes.
Topics: Animals; Choline Deficiency; Ethanolamines; Kinetics; Liver; Male; Methionine; Phosphatidylcholines; Phospholipids; Rats; Rats, Inbred Strains; Solubility | 1991 |
Alterations in expression and methylation of specific genes in livers of rats fed a cancer promoting methyl-deficient diet.
Topics: Animals; Choline Deficiency; Diet; DNA; ErbB Receptors; Gene Expression; Liver; Male; Methionine; Methylation; Neoplasms, Experimental; Proto-Oncogenes; Rats; Rats, Inbred F344; RNA, Messenger; Vitamin B 12 Deficiency | 1991 |
Aflatoxin-DNA adduct formation in chronically dosed rats fed a choline-deficient diet.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Choline Deficiency; Diet; DNA; Liver; Male; Methionine; Radioisotope Dilution Technique; Rats; Rats, Inbred F344; Rats, Inbred Strains; Tritium | 1990 |
Feedback regulation of CTP:phosphocholine cytidylyltransferase translocation between cytosol and endoplasmic reticulum by phosphatidylcholine.
Topics: Biological Transport; Choline; Choline Deficiency; Choline-Phosphate Cytidylyltransferase; Cytosol; Diglycerides; Endoplasmic Reticulum; Fatty Acids; Feedback; Golgi Apparatus; Homeostasis; Liver; Lysophosphatidylcholines; Methionine; Nucleotidyltransferases; Phosphatidylcholines; Phosphorylation | 1990 |
The effect of choline and methionine deficiencies on the number and volume percentage of altered hepatic foci in the presence or absence of diethylnitrosamine initiation in rat liver.
Topics: Animals; Body Weight; Choline Deficiency; Diethylnitrosamine; DNA Damage; Liver; Liver Neoplasms, Experimental; Male; Methionine; Organ Size; Precancerous Conditions; Rats; Rats, Inbred Strains | 1990 |
Usefulness of rapid production model for pancreatic carcinoma in male hamsters.
Topics: Animals; Carcinoma; Choline Deficiency; Cricetinae; Disease Models, Animal; Ethionine; Gallbladder; Male; Methionine; Nitrosamines; Pancreas; Pancreatic Neoplasms | 1990 |
No measurable increase in thymidine glycol or 8-hydroxydeoxyguanosine in liver DNA of rats treated with nafenopin or choline-devoid low-methionine diet.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Choline Deficiency; Deoxyguanosine; DNA; DNA Damage; Electrochemistry; Liver; Male; Methionine; Nafenopin; Propionates; Rats; Rats, Inbred F344; Thymine | 1990 |
L-azaserine induced preneoplasia in the rat pancreas. A morphometric study of dietary manipulation (lipotrope deficiency) and ultrastructural differentiation.
Topics: Animals; Azaserine; beta-Lipotropin; Cell Transformation, Neoplastic; Choline Deficiency; Cytoplasmic Granules; Diet; Enzyme Precursors; Folic Acid Deficiency; Male; Methionine; Microscopy, Electron; Pancreas; Pancreatic Neoplasms; Precancerous Conditions; Rats; Rats, Inbred Lew; Vitamin B 12 Deficiency | 1990 |
Effects of 5-azacytidine and methyl-group deficiency on NAD(P)H: quinone oxidoreductase and glutathione S-transferase in liver.
Topics: Animals; Azacitidine; Choline Deficiency; DNA; Electrophoresis, Agar Gel; Enzyme Induction; Glutathione Transferase; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred Strains; NAD(P)H Dehydrogenase (Quinone); Quinone Reductases; Rats; Rats, Inbred Strains; RNA, Messenger | 1988 |
Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats.
Topics: Animals; Choline; Choline Deficiency; Deoxyuridine; Diet; DNA Damage; DNA Replication; Folic Acid; Folic Acid Deficiency; Liver; Lymphocytes; Male; Methionine; NAD; Nucleotides; Rats; Rats, Inbred F344; Reference Values; RNA; Spleen; Thymidine | 1989 |
Hepatic content of S-adenosylmethionine, S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability.
Topics: Animals; Biomarkers; Choline Deficiency; Cysteine; Diet; Fatty Liver; Folic Acid Deficiency; Glutathione; Homocysteine; Lipids; Liver; Male; Methionine; Methylation; Niacinamide; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1989 |
Hepatic poly(ADP ribose) polymerase activity in methyl donor-deficient rats.
Topics: Animals; Choline Deficiency; Diet; DNA Damage; DNA Repair; Lipid Metabolism; Liver; Male; Malondialdehyde; Methionine; NAD; Niacinamide; Poly(ADP-ribose) Polymerases; Rats; Rats, Inbred Strains | 1989 |
Methyl group deficiency: effects on one-carbon unit and folate metabolism.
Topics: Animals; Choline Deficiency; Folic Acid; Glycine N-Methyltransferase; Methionine; Methylation; Methyltransferases; Oxidation-Reduction; Rats | 1989 |
Altered expression of retrovirus-like sequences and cellular oncogenes in mice fed methyl-deficient diets.
Topics: Animals; Cell Division; Choline Deficiency; DNA Replication; Folic Acid Deficiency; Genes, ras; Kinetics; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Proto-Oncogenes; Reference Values; Retroviridae; Transcription, Genetic; Vitamin B 12 Deficiency | 1989 |
Effect of dietary methyl group deficiency on one-carbon metabolism in rats.
Topics: Amino Acids; Animals; Carbon; Choline Deficiency; Diet; Glycine N-Methyltransferase; Liver; Male; Methionine; Methylation; Methyltransferases; Organ Size; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; S-Adenosylmethionine; Weight Gain | 1989 |
DNA strand break accumulation, thymidylate synthesis and NAD levels in lymphocytes from methyl donor-deficient rats.
Topics: Animals; Cell Count; Choline Deficiency; DNA; DNA Damage; DNA Repair; Folic Acid Deficiency; Lipid Metabolism; Liver; Lymphocytes; Methionine; NAD; Organ Size; Rats; Rats, Inbred Strains; Spleen; Thymidine Monophosphate; Thymine Nucleotides | 1989 |
Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver.
Topics: Animals; Choline Deficiency; Liver; Male; Methionine; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 1989 |
Rapid appearance of hypomethylated DNA in livers of rats fed cancer-promoting, methyl-deficient diets.
Topics: Animals; Choline Deficiency; DNA; Folic Acid Deficiency; Liver; Male; Methionine; Methylation; Neoplasms, Experimental; Rats; Rats, Inbred F344; RNA, Transfer; Vitamin B 12 Deficiency | 1989 |
Effect of dietary methyl group deficiency on folate metabolism in rats.
Topics: Amino Acids; Animals; Choline Deficiency; Chromatography, High Pressure Liquid; Diet; Folic Acid; Leucovorin; Liver; Male; Methionine; Methylation; Rats; Rats, Inbred F344; Tetrahydrofolates | 1989 |
Initiation of carcinogenesis by a dietary deficiency of choline in the absence of added carcinogens.
Topics: Animals; Carcinogens; Choline Deficiency; Diet; Dietary Proteins; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Methionine; Rats; Rats, Inbred F344 | 1987 |
Phosphatidylethanolamine levels and regulation of phosphatidylethanolamine N-methyltransferase.
Topics: Animals; Cells, Cultured; Choline; Choline Deficiency; Endoplasmic Reticulum; Homeostasis; Kinetics; Liver; Male; Methionine; Methyltransferases; Microsomes, Liver; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Rats; Rats, Inbred Strains; Reference Values | 1989 |
Hepatic neoplastic nodules, adenofibrosis, and cholangiocarcinomas in male Fisher 344 rats fed corn naturally contaminated with Fusarium moniliforme.
Topics: Adenoma, Bile Duct; Animals; Choline Deficiency; Food Microbiology; Fusarium; Liver; Liver Neoplasms, Experimental; Male; Methionine; Rats; Rats, Inbred F344; Zea mays | 1985 |
Enhanced phosphatidylinositol kinase activity is associated with early stages of hepatocarcinogenesis and hepatocellular carcinoma.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Carcinoma, Hepatocellular; Choline Deficiency; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methionine; Phosphotransferases; Precancerous Conditions; Rats; Rats, Inbred F344 | 1985 |
Lipotropic factors and oncogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Choline Deficiency; Folic Acid Deficiency; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Neoplasms, Experimental; Methionine; Vitamin B 12 Deficiency | 1986 |
Effects of unilateral ureteric occlusion on renal necrosis occurring in rats fed a methyl-deficient diet.
Topics: Acute Kidney Injury; Animals; Body Weight; Choline Deficiency; Diet; Feeding Behavior; Folic Acid Deficiency; Kidney; Kidney Cortex Necrosis; Kidney Tubular Necrosis, Acute; Male; Methionine; Rats; Rats, Inbred Strains; Ureteral Obstruction; Vitamin B 12 Deficiency | 1988 |
Rapid production of pancreatic carcinoma by initiation with N-nitroso-bis(2-oxopropyl)amine and repeated augmentation pressure in hamsters.
Topics: Animals; Carcinogens; Carcinoma; Choline Deficiency; Cocarcinogenesis; Cricetinae; Diet; Ethionine; Female; Liver; Mesocricetus; Methionine; Nitrosamines; Pancreatic Neoplasms | 1988 |
The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes.
Topics: Animals; Apolipoproteins B; Apolipoproteins C; Apolipoproteins E; Choline; Choline Deficiency; Leucine; Lipoproteins, VLDL; Liver; Male; Methionine; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Rats, Inbred Strains; Triglycerides | 1988 |
Comparison of methyltransferase activities of pair-fed rats given adequate or methyl-deficient diets.
Topics: Animals; Choline Deficiency; Folic Acid Deficiency; Male; Methionine; Methylation; Protein Methyltransferases; Rats; Rats, Inbred F344; tRNA Methyltransferases; Vitamin B 12 Deficiency | 1988 |
Glutathione and enzymes related to free radical metabolism in liver of rats fed a choline-devoid low-methionine diet.
Topics: Animals; Choline Deficiency; Free Radicals; Glutathione; Lipid Peroxides; Liver; Male; Methionine; Rats; Rats, Inbred F344 | 1988 |
Lipid peroxidation in choline-methionine deficiency.
Topics: Choline Deficiency; Ferritins; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Methionine; Microsomes, Liver; Vitamin E | 1987 |
Stimulation of the methylation pathway for phosphatidylcholine synthesis in rat lungs by choline deficiency.
Topics: Animals; Carbon Radioisotopes; Choline Deficiency; Ethanolamine; Ethanolamines; Kinetics; Lung; Male; Methionine; Methylation; Phosphatidylcholines; Phosphatidylethanolamines; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains | 1986 |
Ethionine in the analysis of the possible separate roles of methionine and choline deficiencies in carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Choline Deficiency; Ethionine; Liver Neoplasms, Experimental; Methionine; Models, Biological | 1986 |
Probable free radical effects on rat liver nuclei during early hepatocarcinogenesis with a choline-devoid low methionine diet.
Topics: Aldehydes; Animals; Carbon Tetrachloride Poisoning; Cell Division; Cell Nucleus; Choline Deficiency; Cyclic N-Oxides; Diet; DNA Damage; Free Radicals; L-Iditol 2-Dehydrogenase; Lipid Peroxides; Liver; Liver Neoplasms, Experimental; Male; Methionine; Nitrogen Oxides; Rats; Rats, Inbred F344 | 1987 |
Hepatocyte-like cells within the pancreas of rats fed methyl-deficient diets.
Topics: Animals; Cell Differentiation; Choline Deficiency; Diet; Diethylnitrosamine; Liver; Male; Methionine; Pancreas; Rats; Rats, Inbred F344 | 1986 |
A comparison of the response of woodchucks and rats to variations in dietary lipotrope and protein content.
Topics: Animals; Body Weight; Choline Deficiency; Diet; Fatty Liver; Folic Acid Deficiency; Male; Marmota; Methionine; Protein Deficiency; Rats; Rats, Inbred F344; Sciuridae; Species Specificity; Vitamin B 12 Deficiency | 1986 |
Differential response of lung and liver of juvenile rats to choline deficiency.
Topics: Animals; Body Weight; Choline Deficiency; Lipid Metabolism; Liver; Lung; Male; Methionine; Pulmonary Surfactants; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Altered tRNA methylation in rats and mice fed lipotrope-deficient diets.
Topics: Animals; Choline Deficiency; Folic Acid Deficiency; Liver; Male; Methionine; Methylation; Mice; Rats; RNA, Transfer; tRNA Methyltransferases; Vitamin B 12 Deficiency | 1986 |
Effect of dietary protein and amino acids in a choline-deficient diet on lipid accumulation in rat liver.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Body Composition; Body Weight; Caseins; Choline Deficiency; Depression, Chemical; Diet Therapy; Dietary Proteins; Fatty Liver; Female; Glutamates; Lipid Metabolism; Lipotropic Agents; Liver; Metabolism; Methionine; Ovalbumin; Rats; Serine | 1971 |
Animal model: fatty liver and cirrhosis in lipotrope-deficient male rats.
Topics: Animals; Choline Deficiency; Deficiency Diseases; Diet; Disease Models, Animal; Fatty Liver; Humans; Lipotropic Agents; Liver; Liver Cirrhosis, Experimental; Male; Methionine; Rats; Vitamin B 12 Deficiency | 1973 |
A lipotrope-dependent increase of histidase and urocanase in the livers of choline-deficient rats and in the Reuber H-35 transplanted hepatoma.
Topics: Ammonia-Lyases; Animals; Carcinoma, Hepatocellular; Choline; Choline Deficiency; Diet; Histidine Ammonia-Lyase; Hydro-Lyases; Liver; Liver Neoplasms; Male; Methionine; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Time Factors; Urocanate Hydratase; Vitamin B 12 | 1973 |
Study of one-carbon metabolism in neonatal vitamin B12-deficient rats.
Topics: Animals; Animals, Newborn; Brain Chemistry; Carbon; Carbon Isotopes; Choline Deficiency; Chromatography, Thin Layer; Diet; DNA; Female; Hernia, Umbilical; Hydrocephalus; Lipids; Lipoproteins; Lipotropic Agents; Liver; Methionine; Organ Size; Phospholipids; Pregnancy; Proteins; Rats; RNA; Spinal Dysraphism; Vitamin B 12 Deficiency | 1969 |
Studies on the phospholipid metabolism in choline-deficient guinea pigs. I. Increased activity of lecithin synthesis in liver slices.
Topics: Adenosine Triphosphatases; Amino Alcohols; Animals; Body Weight; Carbon Isotopes; Choline; Choline Deficiency; Chromatography, Thin Layer; Female; Guinea Pigs; In Vitro Techniques; Liver; Male; Methionine; Organ Size; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorus Isotopes; Proteins; Transferases; Tritium | 1970 |
Choline oxidation and labile methyl groups in normal and choline-deficient rat liver.
Topics: Acetates; Alcohol Oxidoreductases; Aldehydes; Animals; Autoradiography; Betaine; Carbon Isotopes; Choline; Choline Deficiency; Chromatography; Fatty Acids, Nonesterified; Kinetics; Liver; Male; Methionine; Methylation; Mitochondria, Liver; NAD; Oxidoreductases; Phosphatidylcholines; Rats; S-Adenosylmethionine; Serotonin; Subcellular Fractions; Triglycerides; Tritium | 1972 |
Effects of choline-deficient diets on the rat hepatocyte. Electron microscopic observations.
Topics: Animals; Choline Deficiency; Diet; Endoplasmic Reticulum; Golgi Apparatus; Histocytochemistry; Lipids; Lipoproteins, VLDL; Liver; Male; Methionine; Microscopy, Electron; Rats; Rats, Inbred Strains; Time Factors | 1970 |
Vitamin B 12 and methionine metabolism in the Buffalo rat liver and Morris 5123 hepatoma.
Topics: Animals; Carcinoma, Hepatocellular; Choline Deficiency; Fatty Liver; Folic Acid; Homocystine; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Methionine; Methylation; Neoplasms, Experimental; Nutrition Disorders; Rats; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
Influence of dietary protein and methionine levels on the requirement for choline by chickens.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Bone Diseases; Chickens; Choline; Choline Deficiency; Dietary Proteins; Dose-Response Relationship, Drug; Female; Male; Methionine; Nutritional Requirements; Oviposition | 1974 |
Phosphatidylethanolamine metabolism in rats fed a low methionine, choline-deficient diet.
Topics: Animal Nutritional Physiological Phenomena; Animals; Carbon Isotopes; Choline Deficiency; Chromatography, Gas; Chromatography, Thin Layer; Deficiency Diseases; Diet; Ethanolamines; Fatty Acids; Fatty Acids, Unsaturated; Half-Life; Lipid Metabolism; Liver; Male; Methionine; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Regression Analysis | 1973 |
Significance of dietary carnitine for growth and carnitine turnover in rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Composition; Body Weight; Carbon Radioisotopes; Carnitine; Choline; Choline Deficiency; Cysteine; Diet; Dietary Fats; Half-Life; Liver; Male; Methionine; Muscles; Organ Size; Rats; Urine | 1974 |
Relationship of arginine and methionine to creatine formation in chicks.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Arginine; Betaine; Body Weight; Chickens; Choline; Choline Deficiency; Creatine; Cystine; Deficiency Diseases; Depression, Chemical; Folic Acid; Folic Acid Deficiency; Glycine; Glycine max; Guanidines; Lipid Metabolism; Liver; Male; Methionine; Muscles; Ornithine; Stimulation, Chemical; Urea; Vitamin B 12; Vitamin B 12 Deficiency; Zea mays | 1971 |
Time sequence of liver phospholipid alterations during deprivation of dietary choline.
Topics: Animals; Arachidonic Acids; Body Weight; Caproates; Choline; Choline Deficiency; Chromatography, Gas; Diet; Linoleic Acids; Lipids; Liver; Male; Methionine; Organ Size; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorus; Rats; Sphingomyelins; Time Factors; Valerates | 1971 |
Studies on the phospholipid metabolism in choline-deficient guinea pigs. II. Effects of feeding on a N-methylethanolamine-supplemented diet.
Topics: Amino Alcohols; Animals; Body Weight; Carbon Isotopes; Choline; Choline Deficiency; Diet; Female; Guinea Pigs; Liver; Male; Methionine; Methylation; Microsomes, Liver; Organ Size; Phospholipids; Phosphotransferases; Triglycerides; Tritium | 1970 |
The relation of dietary choline and methionine to phospholipid synthesis in the rat.
Topics: Animals; Carbon Isotopes; Choline; Choline Deficiency; Cytosine Nucleotides; Dialysis; Diet; Liver; Male; Methionine; Methylation; Microsomes, Liver; Nucleosides; Phospholipids; Rats | 1970 |
The conversion of phosphatidyl ethanolamines to lecithins in normal and choline-deficient rats.
Topics: Animals; Carbon Isotopes; Centrifugation; Choline; Choline Deficiency; Chromatography, Thin Layer; Diet; Female; Male; Methionine; Microsomes, Liver; Nucleosides; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Sex Factors; Time Factors; Transferases | 1971 |
Diet and 14CH3-methionine incorporation into liver phosphatidylcholine fractions of male and female rats.
Topics: Animals; Body Weight; Carbon Isotopes; Choline; Choline Deficiency; Diet; Dietary Fats; Fats, Unsaturated; Fatty Acids; Female; Liver; Male; Methionine; Oils; Phosphatidylcholines; Phosphatidylethanolamines; Rats; Sex Factors | 1971 |
Choline level and its effect on egg weight in the Japanese quail.
Topics: Animal Nutritional Physiological Phenomena; Animals; Biotin; Bird Diseases; Birds; Choline Deficiency; Eggs; Female; Folic Acid; Inositol; Methionine; Nutritional Requirements; Ovulation; Vitamin B 12 | 1971 |
The effect of choline supplementation of diets for growing pullets and laying hens.
Topics: Amino Alcohols; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Betaine; Body Weight; Chickens; Choline; Choline Deficiency; Female; Lipids; Liver; Male; Methionine; Nutritional Requirements; Ovulation; Poultry Diseases | 1971 |
Studies in phospholipid metabolism. 2. Incorporation of metabolic precursors of phospholipids in choline deficiency.
Topics: Amino Alcohols; Animals; Carbon Isotopes; Choline; Choline Deficiency; Liver; Male; Methionine; Palmitic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Tritium | 1968 |
[Characteristics of endogenous amino acid imbalance in choline-protein insufficiency].
Topics: Amino Acids; Amino Alcohols; Animals; Aspartic Acid; Choline Deficiency; Glutamates; Liver; Male; Methionine; Protein Deficiency; Rats; Serine | 1968 |
The induction of liver cirrhosis in rats by purified amino acid diets.
Topics: Amino Acids; Animals; Body Weight; Cholesterol; Choline Deficiency; Deficiency Diseases; Diet; Dietary Proteins; DNA; Fatty Liver; Lipids; Liver; Liver Cirrhosis; Male; Methionine; Rats; Thymidine; Triglycerides; Tritium; Vitamin B 12 Deficiency | 1969 |
Labelling of liver and plasma lecithins after injection of 1-2-14C-2-demethylaminoethanol and 14C-L-methionine-methyl to choline deficient rats.
Topics: Amino Acids; Amino Alcohols; Animals; Carbon Isotopes; Choline Deficiency; Ethanol; Liver; Male; Methionine; Methylation; Phosphatidylcholines; Rats | 1969 |
Studies on phospholipid metabolism in choline deficient fatty liver.
Topics: Animals; Carbon Isotopes; Choline; Choline Deficiency; Chromatography; Fatty Acids; Fatty Liver; Female; Male; Methionine; Methylation; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorus Isotopes; Proteins; Rats | 1969 |
Influence of ethionine on choline-deficiency fatty liver.
Topics: Alcohol Oxidoreductases; Animals; Body Weight; Carbon Isotopes; Choline Deficiency; Depression, Chemical; Ethionine; Fasting; Fatty Liver; Female; Lipid Metabolism; Liver; Male; Methionine; Organ Size; Protein Biosynthesis; Proteins; Rats; Time Factors | 1969 |
Metabolism of phosphorylcholine and lecithin in normal and choline-deficient rats.
Topics: Animals; Carbon Isotopes; Choline; Choline Deficiency; Fatty Liver; Lipid Metabolism; Liver; Male; Methionine; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Phosphorus Isotopes; Rats | 1969 |
Choline metabolism in normal and choline-deficient rats of different ages.
Topics: Aging; Animals; Body Weight; Choline; Choline Deficiency; Fatty Liver; Hemorrhage; Kidney; Liver; Methionine; Rats; Vitamin B Deficiency | 1965 |
Environmental temperature and choline requirements in rats. II. Choline and methionine requirements for lipotropic activity.
Topics: Animals; Choline; Choline Deficiency; Deficiency Diseases; Fatty Liver; Lipid Metabolism; Liver; Methionine; Rats; Temperature | 1966 |
Amino alcohols and methyl donors in rats fed low choline diets containing added cholesterol.
Topics: Amino Alcohols; Animals; Betaine; Cholesterol; Choline Deficiency; Dietary Fats; Fats; Liver; Methionine; Quaternary Ammonium Compounds; Rats | 1966 |
Effect of diets marginal in methionine and choline with and without vitamin B 12 on rat liver and kidney.
Topics: Animals; Choline; Choline Deficiency; Deficiency Diseases; Kidney Diseases; Liver Diseases; Methionine; Rats; Vitamin B 12; Vitamin B 12 Deficiency | 1966 |