Page last updated: 2024-08-17

methionine and Acute Confusional Senile Dementia

methionine has been researched along with Acute Confusional Senile Dementia in 125 studies

Research

Studies (125)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	23 (18.40)	18.2507
2000's	49 (39.20)	29.6817
2010's	41 (32.80)	24.3611
2020's	12 (9.60)	2.80

Authors

Authors	Studies
Asara, JM; Binari, R; Filine, E; Jouandin, P; Leshchiner, D; Parkhitko, AA; Perrimon, N; Rabinowitz, JD; Wang, L	1
Agrawal, A; Agrawal, S; Alachkar, A; Baboldashtian, M; Nuseir, K; Salazar, J	1
Hu, X; Li, X; Tian, P	1
Chen, Y; Du, Y; Duan, H; Fu, J; Huang, G; Huang, L; Li, W; Li, Z; Liu, H; Liu, Q; Ma, F; Sun, C; Sun, Y; Wang, G; Wang, Z; Zhao, J; Zhou, D; Zhu, Y	1
Adamkov, M; Hnilicova, P; Kalenska, D; Kovalska, L; Kovalska, M; Lehotsky, J	1
Barnham, KJ; Churilov, L; Holper, S; Lim, YY; Watson, R; Yassi, N; Yates, P	1
Cho, SH; Choi, HK; Kim, JS; Kim, KK; Kim, MG; Koo, BS; Lee, YB; Liu, QF; Ryu, JE; Shin, SJ	1
Benyo, Z; Csik, B; Csiszar, A; Gulej, R; Mukli, P; Negri, S; Tarantini, S; Ungvari, A; Ungvari, Z; Yabluchanskiy, A	1
Bian, F; Hou, Y; Jia, P; Liu, J; Shi, W; Song, J; Sun, S; Wu, H; Wu, Z; Zhang, Y	1
Coppedè, F; Migliore, L; Stoccoro, A; Tannorella, P	1
Caselli, RJ; Chen, K; Chen, Y; Huentelman, M; Lee, W; Locke, DEC; Lu, B; Reiman, EM; Richholt, R; Stonnington, CM; Su, Y; Syed, S; Thiyyagura, P; Velgos, SN	1
Jiang, Y; Pi, T; Shi, JS; Wei, S	1
Ano, Y; Nakayama, H; Uchida, K; Yoshino, Y	1
Brender, JR; Kotov, NA; Krishnamoorthy, J; Marsh, EN; Ramamoorthy, A; Ruotolo, BT; Soper, MT; Suzuki, Y; Zhou, Y	1
Han, F; Hou, L; Lee, HG; Perry, G; Smith, MA; Tedesco, JM; Zagorski, MG	1
Ames, D; Bourgeat, P; Bush, AI; Darby, D; Ellis, KA; Harrington, KD; Laws, SM; Lim, YY; Martins, RN; Maruff, P; Masters, CL; Nathan, PJ; Pietrzak, RH; Rowe, CC; Salvado, O; Snyder, PJ; Villemagne, VL	1
Anfossi, M; Bernardi, L; Bruni, AC; Clodomiro, A; Colao, R; Conidi, ME; Curcio, SA; Di Lorenzo, R; Frangipane, F; Gallo, M; Maletta, R; Mirabelli, M; Puccio, G; Smirne, N; Vasso, F	1
Soloway, AH; Soloway, PD; Warner, VD	1
Kobayashi, N; Kondo, K; Nagata, T; Nakayama, K; Shinagawa, S; Yamada, H	1
Alvarez-Retuerto, AI; Benzinger, T; Chakraverty, S; Coppola, G; Fagan, A; Goate, A; Hecimovic, S; Kepe, V; Porter, V; Ringman, JM; Ting, SK	1
Bevan, DR; Brown, AM; Lemkul, JA; Schaum, N	1
Chen, QH; Fan, J; Han, YQ; Nan, SJ	1
Jia, J; Li, D; Li, H; Qin, W; Wang, Q; Wu, L	1
Kim, S; Violette, CJ; Ziff, EB	1
Arrazola, MS; Bunout, D; Hirsch, S; Inestrosa, NC; Lindsay, CB; Montecinos-Oliva, C; Retamales, RM; Tapia-Rojas, C	1
Bowman, CF; Du, F; Moskovitz, J; Yan, SS	1
Chung, YC; Feierman, E; Kruyer, A; Norris, EH; Richards, A; Strickland, S; Yao, Y	1
Allegri, R; Bateman, RJ; Benzinger, TL; Chhatwal, J; Cruchaga, C; Fagan, AM; Farlow, MR; Goate, A; Graff-Radford, NR; Hassenstab, J; Holtzman, DM; Laske, C; Levin, J; Lim, YY; Maruff, P; Masters, CL; McDade, E; Morris, JC; Ringman, JM; Rossor, M; Salloway, S; Schofield, PR; Snyder, PJ	1
André, I; Faller, P; Gras, E; Hoarau, M; Hureau, C; Irague, R; Malbert, Y; Remaud-Siméon, M	1
Mohajeri, MH; Troesch, B; Weber, P	1
Carelli-Alinovi, C; Misiti, F	1
Prakash, A; Singh, M	1
Shea, TB; Tchantchou, F	1
Angerhofer, A; da Silva, GF; Lykourinou, V; Ming, LJ	1
Akatsu, H; Arboleda, H; Asada, T; Combarros, O; Comings, DE; Fujii, T; Fukumoto, N; Goto, Y; Grupe, A; Hyman, BT; Ingelsson, M; Kamboh, MI; Kunugi, H; Matsushita, S; Mattila, KM; Nacmias, B; Nakamura, S; Nishimura, AL; Rinne, J; Tsai, SJ; Zatz, M	1
Bredesen, DE; Butterfield, DA; Fombonne, J; Galvan, V; Gorostiza, O; Lange, MB; Sowell, RA; Spilman, P; Sultana, R; Tang, H; Zhang, J	1
Barnham, KJ; Brinck, T; Bush, AI; Haeffner, F	1
Abbamondi, N; Anfossi, M; Bernardi, L; Bruni, AC; Bugiani, O; Clodomiro, A; Colao, R; Curcio, SA; Di Lorenzo, R; Foncin, JF; Forloni, G; Frangipane, F; Gallo, M; Geracitano, S; Giaccone, G; Leotta, A; Lio, SG; Maletta, R; Milan, G; Mirabelli, M; Muraca, MG; Nee, L; Pappatà, S; Pinessi, L; Postiglione, A; Puccio, G; Rainero, I; Rogaeva, E; Rubino, E; Smirne, N; Sorbi, S; Spillantini, MG; St George Hyslop, P; Terni, B; Tomaino, C	1
Bosco, P; Cento, RM; Costantini, B; Ferri, R; Lanzone, A; Macrì, F; Perri, C; Proto, C; Suriano, R; Villa, P	1
Krack, L; Kretzschmar, H; Meissner, B; Redyk, K; Roeber, S; Schmidt, C; von Ahsen, N; Zerr, I	1
Praticò, D; Zhuo, JM	1
Hirota, M; Morisawa, H; Nakamura, M; Nishigaki, R; Toda, T; Yoshimi, Y	1
Fan, M; Jiang, T; Liu, B; Song, M; Wang, Z; Xu, C; Zhen, X	1
Majercak, J; Marlatt, MW; McCampbell, A; Podtelezhnikov, A; Ray, WJ; Savage, M; Szczerba, P; Tanis, KQ; Toolan, D; Wessner, K; Wolffe, C; Yeh, S; Zhang, R	1
Almkvist, O; Bogdanovic, N; Långström, B; Nordberg, A; Schöll, M; Viitanen, M; Wall, A	1
Baker, GB; Cao, X; Chlan-Fourney, J; Gabriel, GG; Mousseau, DD; Nazarali, AJ; Pennington, PR; Rui, L; Wei, Z	1
Attar, A; Bitan, G; Hayes, J; Liu, T; Lopes, DH; Maiti, P; Mittal, S; Moskovitz, J; Oien, DB	1
Bhatia, S; Else, PL; Garner, B; Kim, WS; Knoch, B; Oakley, AJ; Wong, J	1
Baker, A; Bredesen, DE; Butterfield, DA; Cai, J; Fiorini, A; Fombonne, J; Galvan, V; Gorostiza, O; Lange, MB; Pierce, WM; Robinson, RA; Sultana, R; Zhang, J	1
Cagnin, A; Fabrizi, GM; Pompanin, S; Testi, S	1
Bonasera, SJ; Boxer, AL; Cholfin, JA; Crawford, RK; Gennatas, ED; Gorno-Tempini, ML; Karydas, A; Kramer, JH; Miller, BL; Rankin, KP; Rosen, HJ; Sasaki, DA; Seeley, WW; Weiner, M; Zhou, J	1
Bitan, G; Coppola, G; Cummings, JL; Elashoff, D; Fithian, AT; Gylys, K; Moskovitz, J; Pratico, D; Ringman, JM	1
Biundo, F; Cuzzoni, G; Garbin, G; Govoni, S; Lanni, C; Lisa, A; Racchi, M; Ranzani, GN; Ranzenigo, A; Sinforiani, E	1
Amouyel, P; Clément, Y; Fonbonne, C; Girod, M; Lambert, JC; Lantéri, P; Lemoine, J; Salvador, A; Simon, R	1
Butterfield, DA; Sultana, R; Swomley, AM	1
Fan, H; Fu, X; He, J; Huang, J; Li, X; Yang, J; Zhang, Y	1
Butterfield, DA; Kanski, J	1
Hou, L; Kang, I; Marchant, RE; Zagorski, MG	1
Lyons-Weiler, J; Rogers, E; Shea, TB	1
Brunelle, P; Rauk, A	1
Butterfield, DA	1
Miller, AL	1
du Plessis, DG; Larner, AJ	1
Asada, T; Goto, Y; Hachiya, NS; Kaneko, K; Kimura, H; Kinoshita, T; Mizusawa, H; Ohkubo, T; Sakasegawa, Y	1
Levine, RL; Moskovitz, J; Stadtman, ER	1
Bobrowski, K; Hug, GL; Pogocki, D; Schöneich, C	1
Hong, CJ; Hsu, LE; Lin, CH; Liu, HC; Liu, TY; Tsai, SJ	1
Pogocki, D	1
Clementi, ME; Giardina, B; Martorana, GE; Misiti, F; Pezzotti, M	1
Boyd-Kimball, D; Butterfield, DA; Mohmmad-Abdul, H; Sultana, R	1
Boyd-Kimball, D; Butterfield, DA	1
Brooks, WS; Gregory, G; Halliday, GM; Kersaitis, C; Kril, JJ; Kwok, JB; Lepar, G; Rahimi, F; Schofield, PR; Shepherd, CE; Song, YJ	1
Ali, FE; Barnham, KJ; Barrow, CJ; Bush, AI; Cherny, RA; Fraser, F; Masters, CL; Separovic, F	1
Schöneich, C	2
Houee-Levin, C; Kadlcik, V; Kodicek, M; Mattioli, TA; Sicard-Roselli, C	1
Andrews, LG; Liu, L; Tollefsbol, TO; Ulrey, CL	1
Kaji, R; Kawakami, H; Kuno, S; Nishimura, M	1
Ceccarelli, L; Clementi, ME; Coletta, M; Giardina, B; Marini, S; Misiti, F; Pezzotti, M; Sampaolese, B	1
DeKosky, ST; Desai, P; Kamboh, MI; Nebes, R	1
Catanese, J; Goate, A; Grupe, A; Hardy, J; Li, Y; Lovestone, S; Morris, JC; Owen, M; Powell, J; Rowland, C; Sninsky, J; Tacey, K; Thal, L; Williams, J	1
Hara, H; Irie, K; Murakami, K; Nagao, M; Ohigashi, H; Shimizu, T; Shirasawa, T	1
McCaddon, A; Regland, B	1
Clementi, ME; Giardina, B; Grassi, C; Mezzogori, D; Misiti, F; Orsini, F; Pezzotti, M; Sampaolese, B	1
Bostwick, DE; Chin, LS; Choi, J; Gearing, M; Levey, AI; Li, L; Olzmann, JA; Rees, HD; Sullards, MC; Weintraub, ST	1
Chuu, JY; Murphy, GM; Noda, A; Taylor, JL; Tinklenberg, J; Yesavage, J	1
Archetti, S; Borroni, B; Caimi, L; Costanzi, C; Franzoni, S; Grassi, M; Padovani, A; Zanetti, M	1
Brunelle, P; Gómez-Balderas, R; Raffa, DF; Rauk, A; Rickard, GA	1
Shea, TB	1
Gillis, T; Gusella, JF; Hakky, MM; Hayden, M; Kishikawa, S; Li, JL; MacDonald, ME; Myers, RH; Warby, S	1
Boelens, WC; Kamps, B; Narayanan, S; Reif, B	1
Bogdanovic, N; Karelson, E; Land, T; Reis, K; Zharkovsky, A	1
Boeras, DI; Crespo, NC; Granic, A; Padmanabhan, J; Potter, H; Rojiani, AM	1
Bergquist, J; Johansson, AS; Lannfelt, L; Leist, M; Päiviö, A; Volbracht, C; Westlind-Danielsson, A	1
He, XM; Hong, Z; Tang, MN; Wu, CB; Zhang, JW; Zhang, ZX; Zhou, YT	1
Chojnacka, K; Dorszewska, J; Florczak, J; Jaroszewska-Kolecka, J; Kempisty, B; Kozubski, W; Rozycka, A; Trzeciak, WH	1
Hong, CJ; Hsieh, CH; Liou, YJ; Liu, ME; Tsai, SJ; Tsai, YL	1
Antolini, L; Conti, E; DeFilippi, F; Facheris, M; Fenaroli, F; Ferrarese, C; Galimberti, G; Isella, V; Perlangeli, V; Piazza, F; Zini, M	1
Bai, F; Deng, LL; Qian, Y; Shi, YM; Yu, H; Yuan, YG; Zhang, ZJ	1
Irie, K; Masuda, Y; Nakanishi, A; Ohashi, R; Shimizu, T; Shirasawa, T; Takegoshi, K; Uemura, S	1
Macq, AF; Octave, JN; Philippe, B	1
Cotman, CW; Cribbs, DH; Glabe, CG; Kosmoski, J; Pike, CJ; Walencewicz-Wasserman, AJ	1
Capell, A; Citron, M; Haass, C; Selkoe, DJ; Teplow, DB	1
Citron, M; Johnston, J; Lannfelt, L; Miller, C; Schenk, D; Selkoe, DJ; Teplow, DB; Venizelos, N; Vigo-Pelfrey, C; Winblad, B	1
Czernik, AJ; Greengard, P; Marshak, DR; Nairn, AC; Oishi, M; Suzuki, T	1
De Sousa, MA; Itzhaki, RF; Robinson, NR	1
Johnson, G; Refolo, LM; Wallace, W	1
Demoise, DC; Lee, VM; Merrick, SE	1
Comar, D; Degueldre, C; Delfiore, G; Franck, G; Gregoire, MC; Lemaire, C; Salmon, E	1
Haghighi, AZ; Maples, KR	1
Bryder, M; Bus, C; Jørgensen, AL; Jørgensen, P; Pallisgaard, N	1
Castaño, EM; Levy, E; Mangone, CA; Morelli, L; Prat, MI	1
Citron, M; Corcoran, C; Diehl, TS; Eckman, CB; Levesque, G; Ostaszewski, BL; Selkoe, DJ; St George Hyslop, P; Xia, W; Younkin, SG	1
Dyrks, T; Turner, J; Urmoneit, B	1
Ancolio, K; Barelli, H; Brice, A; Campion, D; Checler, F; Dumanchin, C; Frébourg, T; Warter, JM	1
Hong, A; Ma, K; Shao, H; Yang, J; Zagorski, MG; Zeng, H	1
Daly, J; Kotwal, GJ; Lahiri, DK	1
Butterfield, DA; Jahanshahi, F; Kanski, J; Varadarajan, S; Yatin, S	1
Service, RF	1
Aksenova, M; Butterfield, DA; Kanski, J; Lauderback, C; Varadarajan, S	1
Emile, J; Houlgatte, R; Jabbour, W; Pouplard-Barthelaix, A	1
Gottfries, CG; Regland, B	1
Bragin, V; Davis, KL; Haroutunian, V; Merril, CR; Robakis, NK; Sambamurti, K; Santucci, AC; VanderPutten, D; Wallace, WC	1
Bierer, L; Charya, S; Haroutunian, V; Johnson, G; Merril, C; Perez, N; Perl, D; Sugar, J; Wallace, W	1
Buxbaum, JD; Cicchetti, P; Czernik, AJ; Ehrlich, ME; Fracasso, RP; Gandy, SE; Greengard, P; Ramabhadran, TV; Unterbeck, AJ	1

Reviews

16 review(s) available for methionine and Acute Confusional Senile Dementia

Article	Year
The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment. Nutrients, 2023, Nov-03, Volume: 15, Issue:21 Topics: Alzheimer Disease; Brain; Cerebrovascular Circulation; Cognitive Dysfunction; Diet; Humans; Hyperhomocysteinemia; Methionine	2023
Potential Links between Impaired One-Carbon Metabolism Due to Polymorphisms, Inadequate B-Vitamin Status, and the Development of Alzheimer's Disease. Nutrients, 2016, Dec-10, Volume: 8, Issue:12 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alzheimer Disease; Animals; Cystathionine beta-Synthase; Evidence-Based Medicine; Ferredoxin-NADP Reductase; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Hyperhomocysteinemia; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Mutagenesis, Insertional; Nutrigenomics; Nutritional Status; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Tandem Repeat Sequences; Vitamin B Complex; Vitamin B Deficiency	2016
Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010, Jan-05, Volume: 153B, Issue:1 Topics: Aged; Alzheimer Disease; Base Sequence; Brain-Derived Neurotrophic Factor; Case-Control Studies; DNA Primers; Female; Genetic Predisposition to Disease; Humans; Male; Methionine; Sex Characteristics; Valine	2010
Proteomic approaches to oxidative protein modifications implicated in the mechanism of aging. Geriatrics & gerontology international, 2010, Volume: 10 Suppl 1 Topics: Aging; Alzheimer Disease; Animals; Cysteine; Electrophoresis, Gel, Two-Dimensional; Humans; Isoelectric Focusing; Methionine; Oxidative Stress; Protein Biosynthesis; Protein Carbonylation; Proteomics; Reactive Oxygen Species	2010
Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression. Antioxidants & redox signaling, 2013, Sep-10, Volume: 19, Issue:8 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Free Radicals; Humans; Methionine; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Protein Structure, Quaternary	2013
The association between the methionine/valine (M/V) polymorphism (rs1799990) in the PRNP gene and the risk of Alzheimer disease: an update by meta-analysis. Journal of the neurological sciences, 2013, Mar-15, Volume: 326, Issue:1-2 Topics: Alzheimer Disease; Case-Control Studies; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Methionine; Polymorphism, Genetic; Prion Proteins; Prions; Valine	2013
Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide 1-42. Peptides, 2002, Volume: 23, Issue:7 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Humans; Lipid Peroxidation; Methionine; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Protein Structure, Secondary; Reactive Oxygen Species	2002
Homocysteine, folate deprivation and Alzheimer neuropathology. Journal of Alzheimer's disease : JAD, 2002, Volume: 4, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Nerve Degeneration	2002
Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. Free radical research, 2002, Volume: 36, Issue:12 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Brain; Free Radical Scavengers; Humans; Lipid Bilayers; Methionine; Molecular Sequence Data; Neurons; Oxidative Stress; Peptide Fragments; Peptides; Protein Structure, Tertiary; Reactive Oxygen Species	2002
The methionine-homocysteine cycle and its effects on cognitive diseases. Alternative medicine review : a journal of clinical therapeutic, 2003, Volume: 8, Issue:1 Topics: Alzheimer Disease; Cardiovascular Diseases; Cognition Disorders; Dementia, Vascular; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Memory Disorders; Methionine; Methionine Adenosyltransferase; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6	2003
Oxidation of methionine residues of proteins: biological consequences. Antioxidants & redox signaling, 2003, Volume: 5, Issue:5 Topics: Aging; Alzheimer Disease; Animals; Cysteine Endopeptidases; Humans; Methionine; Methionine Sulfoxide Reductases; Models, Chemical; Multienzyme Complexes; Oxidation-Reduction; Oxidoreductases; Proteasome Endopeptidase Complex; Proteins; Reactive Oxygen Species; Signal Transduction	2003
Mutation of the Phe20 residue in Alzheimer's amyloid beta-peptide might decrease its toxicity due to disruption of the Met35-cupric site electron transfer pathway. Chemical research in toxicology, 2004, Volume: 17, Issue:3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Copper; Electron Transport; Humans; Methionine; Models, Molecular; Mutation; Oxidation-Reduction; Peptide Fragments; Phenylalanine	2004
Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain. Brain pathology (Zurich, Switzerland), 2004, Volume: 14, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Humans; Lipid Peroxidation; Methionine; Models, Neurological; Nerve Degeneration; Oxidative Stress; Peptide Fragments	2004
Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease. Biochimica et biophysica acta, 2005, Jan-17, Volume: 1703, Issue:2 Topics: Alzheimer Disease; Humans; Methionine; Reactive Oxygen Species	2005
The impact of metabolism on DNA methylation. Human molecular genetics, 2005, Apr-15, Volume: 14 Spec No 1 Topics: Alzheimer Disease; Animals; Arteriosclerosis; DNA Methylation; Folic Acid; Gene Expression Regulation; Glycine N-Methyltransferase; Homocysteine; Humans; Methionine; Methyltransferases; Models, Biological; S-Adenosylmethionine	2005
Redox processes of methionine relevant to beta-amyloid oxidation and Alzheimer's disease. Archives of biochemistry and biophysics, 2002, Jan-15, Volume: 397, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Free Radicals; Humans; Methionine; Models, Chemical; Oxidation-Reduction	2002

Trials

1 trial(s) available for methionine and Acute Confusional Senile Dementia

Article	Year
Protocol of a Phase II Randomized, Multi-Center, Double-Blind, Placebo-Controlled Trial of S-Adenosyl Methionine in Participants with Mild Cognitive Impairment or Dementia Due to Alzheimer's Disease. The journal of prevention of Alzheimer's disease, 2023, Volume: 10, Issue:4 Topics: Alzheimer Disease; Brain; Clinical Trials, Phase II as Topic; Cognitive Dysfunction; Double-Blind Method; Humans; Methionine; Multicenter Studies as Topic; Randomized Controlled Trials as Topic	2023

Article

Year

Protocol of a Phase II Randomized, Multi-Center, Double-Blind, Placebo-Controlled Trial of S-Adenosyl Methionine in Participants with Mild Cognitive Impairment or Dementia Due to Alzheimer's Disease.

The journal of prevention of Alzheimer's disease, 2023, Volume: 10, Issue:4

Topics: Alzheimer Disease; Brain; Clinical Trials, Phase II as Topic; Cognitive Dysfunction; Double-Blind Method; Humans; Methionine; Multicenter Studies as Topic; Randomized Controlled Trials as Topic

2023

Other Studies

108 other study(ies) available for methionine and Acute Confusional Senile Dementia

Article	Year
A genetic model of methionine restriction extends Proceedings of the National Academy of Sciences of the United States of America, 2021, 10-05, Volume: 118, Issue:40 Topics: Aging; Alzheimer Disease; Amino Acids; Animals; Animals, Genetically Modified; Carbon-Sulfur Lyases; Drosophila; Food; Humans; Longevity; Methionine; Models, Genetic	2021
L-methionine enhances neuroinflammation and impairs neurogenesis: Implication for Alzheimer's disease. Journal of neuroimmunology, 2022, 05-15, Volume: 366 Topics: Alzheimer Disease; Animals; Hippocampus; Humans; Inflammation; Methionine; Mice; Microglia; Neurogenesis; Neuroinflammatory Diseases	2022
Association of Met/Val polymorphism of BDNF gene with Alzheimer's disease in Chinese patients. Cellular and molecular biology (Noisy-le-Grand, France), 2022, Apr-30, Volume: 68, Issue:4 Topics: Aged; Alzheimer Disease; Asian People; Brain-Derived Neurotrophic Factor; Case-Control Studies; Genotype; Humans; Methionine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Valine	2022
Circulating Amyloid-β and Methionine-Related Metabolites to Predict the Risk of Mild Cognitive Impairment: A Nested Case-Control Study. Journal of Alzheimer's disease : JAD, 2022, Volume: 90, Issue:1 Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Case-Control Studies; Cognitive Dysfunction; Humans; Methionine; Peptide Fragments; Prospective Studies	2022
Alzheimer's Disease-like Pathological Features in the Dorsal Hippocampus of Wild-Type Rats Subjected to Methionine-Diet-Evoked Mild Hyperhomocysteinaemia. Cells, 2023, 08-17, Volume: 12, Issue:16 Topics: Alzheimer Disease; Animals; Diet; Epigenesis, Genetic; Hippocampus; Hyperhomocysteinemia; Male; Methionine; Racemethionine; Rats; Rats, Wistar	2023
Effect of woohwangchungsimwon and donepezil co-treatment on cognitive function and serum metabolic profiles in a scopolamine-induced model of Alzheimer's disease. Journal of ethnopharmacology, 2024, Jan-30, Volume: 319, Issue:Pt 3 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Donepezil; Humans; Metabolome; Methionine; Mice; Mice, Inbred ICR; Neuroblastoma; Phenylalanine; Reactive Oxygen Species; Scopolamine Derivatives; Tyrosine	2024
Progesterone attenuates Aβ Life sciences, 2020, Jul-15, Volume: 253 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cerebral Cortex; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Gene Knockout Techniques; Gene Silencing; GRB2 Adaptor Protein; Humans; Membrane Proteins; Methionine; Neurons; Neuroprotection; Progesterone; Proteomics; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Signal Transduction; Tandem Mass Spectrometry	2020
Polymorphisms of genes required for methionine synthesis and DNA methylation influence mitochondrial DNA methylation. Epigenomics, 2020, Volume: 12, Issue:12 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNA, Mitochondrial; Female; Ferredoxin-NADP Reductase; Genotype; Humans; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Replication Protein C	2020
Interaction Between BDNF Val66Met and APOE4 on Biomarkers of Alzheimer's Disease and Cognitive Decline. Journal of Alzheimer's disease : JAD, 2020, Volume: 78, Issue:2 Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Cohort Studies; Female; Hippocampus; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Positron-Emission Tomography; Protein Binding; Valine	2020
High Methionine Diet-Induced Alzheimer's Disease like Symptoms Are Accompanied by 5-Methylcytosine Elevated Levels in the Brain. Behavioural neurology, 2021, Volume: 2021 Topics: 5-Methylcytosine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Diet; Disease Models, Animal; Maze Learning; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic	2021
Preventive Effects of Tryptophan-Methionine Dipeptide on Neural Inflammation and Alzheimer's Pathology. International journal of molecular sciences, 2019, Jun-29, Volume: 20, Issue:13 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cytokines; Dietary Supplements; Dipeptides; Female; Methionine; Mice; Microglia; Milk Proteins; Tryptophan	2019
Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR. Biochemistry, 2013, Mar-19, Volume: 52, Issue:11 Topics: Alzheimer Disease; Amyloid beta-Peptides; Circular Dichroism; Humans; Methionine; Microscopy, Atomic Force; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Structure, Secondary; Solubility	2013
Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation. Journal of Alzheimer's disease : JAD, 2013, Volume: 37, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Humans; Methionine; Oxidation-Reduction; Oxidative Stress; Peptide Fragments	2013
BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of aging, 2013, Volume: 34, Issue:11 Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Australia; Brain-Derived Neurotrophic Factor; Cognition Disorders; Female; Genotype; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Memory, Episodic; Methionine; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles; Valine	2013
Role of TOMM40 rs10524523 polymorphism in onset of alzheimer's disease caused by the PSEN1 M146L mutation. Journal of Alzheimer's disease : JAD, 2013, Volume: 37, Issue:2 Topics: Adult; Age of Onset; Alzheimer Disease; Female; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Male; Membrane Transport Proteins; Memory Disorders; Methionine; Middle Aged; Mitochondrial Precursor Protein Import Complex Proteins; Mutation; Neuropsychological Tests; Polymorphism, Genetic; Presenilin-1	2013
Possible chemical initiators of cognitive dysfunction in phenylketonuria, Parkinson's disease and Alzheimer's disease. Medical hypotheses, 2013, Volume: 81, Issue:4 Topics: Alzheimer Disease; Catechols; Cognition Disorders; Humans; Metabolic Networks and Pathways; Methionine; Models, Biological; Molecular Structure; Oxidative Stress; Parkinson Disease; Phenylalanine; Phenylketonurias; Tyrosine	2013
Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease. Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:4 Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Female; Genotype; Humans; Male; Methionine; Neuropsychological Tests; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Statistics as Topic; Valine	2014
A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman. Journal of Alzheimer's disease : JAD, 2014, Volume: 40, Issue:2 Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Black or African American; Brain; Female; Green Fluorescent Proteins; HEK293 Cells; Humans; Isoleucine; Methionine; Middle Aged; Mutation; Positron-Emission Tomography; Presenilin-1; Thiazoles; Transfection	2014
Simulations of monomeric amyloid β-peptide (1-40) with varying solution conditions and oxidation state of Met35: implications for aggregation. Archives of biochemistry and biophysics, 2014, Mar-01, Volume: 545 Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Hydrophobic and Hydrophilic Interactions; Methionine; Molecular Dynamics Simulation; Oxidation-Reduction; Peptide Fragments; Protein Folding; Protein Structure, Secondary	2014
Blepharospasm in familial AD secondary to an APP mutation (V715M). Acta neurologica Belgica, 2014, Volume: 114, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Blepharospasm; Family Health; Female; Humans; Male; Methionine; Middle Aged; Motor Cortex; Mutation; Valine	2014
A Novel AβPP M722K Mutation Affects Amyloid-β Secretion and Tau Phosphorylation and May Cause Early-Onset Familial Alzheimer's Disease in Chinese Individuals. Journal of Alzheimer's disease : JAD, 2015, Volume: 47, Issue:1 Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Asian People; Cell Line, Tumor; Exons; Female; Humans; Lysine; Male; Methionine; Mice; Middle Aged; Mutation; Neuroblastoma; Phosphorylation; tau Proteins	2015
Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant. Neurobiology of aging, 2015, Volume: 36, Issue:12 Topics: Alzheimer Disease; Animals; Calcineurin; Calcium; Calcium Signaling; Cells, Cultured; Cognition; Endoplasmic Reticulum; Hippocampus; Homeostasis; Humans; Learning; Memory; Methionine; Mice, Inbred C57BL; Mutation; Neuronal Plasticity; Neurons; Phosphorylation; Presenilin-1; Receptors, AMPA; Tacrolimus	2015
Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Molecular neurodegeneration, 2015, Nov-21, Volume: 10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Brain; Female; Methionine; Mice, Inbred C57BL; Neurons; Oxidative Stress; Phosphorylation; tau Proteins; Wnt Signaling Pathway	2015
Methionine sulfoxide reductase A affects β-amyloid solubility and mitochondrial function in a mouse model of Alzheimer's disease. American journal of physiology. Endocrinology and metabolism, 2016, Mar-15, Volume: 310, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Respiration; Disease Models, Animal; Electron Transport Complex IV; Gene Knock-In Techniques; Methionine; Methionine Sulfoxide Reductases; Mice; Mice, Knockout; Mitochondria; Solubility	2016
Hyperhomocysteinemia exacerbates Alzheimer's disease pathology by way of the β-amyloid fibrinogen interaction. Journal of thrombosis and haemostasis : JTH, 2016, Volume: 14, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biotinylation; Brain; Cerebral Amyloid Angiopathy; Dementia, Vascular; Disease Models, Animal; Disease Progression; Fibrin; Fibrinogen; Fibrinolysis; Humans; Hyperhomocysteinemia; Immunohistochemistry; Maze Learning; Memory; Methionine; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Binding	2016
BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology, 2016, Volume: 139, Issue:Pt 10 Topics: Adult; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Female; Heterozygote; Hippocampus; Humans; Male; Memory Disorders; Methionine; Middle Aged; tau Proteins; Valine	2016
A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides. PloS one, 2016, Volume: 11, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Humans; Inclusion Bodies; Methionine; Peptide Fragments; Recombinant Proteins; Spectrophotometry, Ultraviolet; Staining and Labeling; Thiazoles	2016
Methionine 35 sulphoxide reduces toxicity of Aβ in red blood cell. European journal of clinical investigation, 2017, Volume: 47, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Caspase 3; Erythrocytes; Glucose; Healthy Volunteers; Humans; Methionine; Methionine Sulfoxide Reductases; Oxidation-Reduction; Pentose Phosphate Pathway	2017
Possible role of endothelin receptor against hyperhomocysteinemia and β-amyloid induced AD type of vascular dementia in rats. Brain research bulletin, 2017, Volume: 133 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Bosentan; Brain; Dementia; Dementia, Vascular; Endothelins; Endothelium, Vascular; Hyperhomocysteinemia; Lipid Peroxidation; Male; Maze Learning; Memory; Methionine; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Receptors, Endothelin; Sulfonamides	2017
Folate deprivation, the methionine cycle, and Alzheimer's disease. Vitamins and hormones, 2008, Volume: 79 Topics: Alzheimer Disease; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Hyperhomocysteinemia; Methionine	2008
Methionine does not reduce Cu(II)-beta-amyloid!--rectification of the roles of methionine-35 and reducing agents in metal-centered oxidation chemistry of Cu(II)-beta-amyloid. Biochimica et biophysica acta, 2009, Volume: 1792, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; Catechol Oxidase; Copper; Dopamine; Electron Spin Resonance Spectroscopy; Humans; In Vitro Techniques; Kinetics; Methionine; Models, Chemical; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Reducing Agents	2009
In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP. Free radical biology & medicine, 2010, Jan-01, Volume: 48, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Humans; Male; Maze Learning; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress	2010
Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease: a DFT study. Journal of molecular modeling, 2010, Volume: 16, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Catalysis; Computer Simulation; Copper; Humans; Hydrogen Peroxide; Methionine; Models, Chemical; Models, Molecular; Molecular Structure; Oxidation-Reduction; Protein Multimerization; Safrole; Solubility	2010
Worldwide distribution of PSEN1 Met146Leu mutation: a large variability for a founder mutation. Neurology, 2010, Mar-09, Volume: 74, Issue:10 Topics: Adult; Alzheimer Disease; Brain; Cognition Disorders; Family Health; Female; Fluorodeoxyglucose F18; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Global Health; History, 17th Century; History, 21st Century; Humans; International Cooperation; Italy; Leucine; Male; Memory Disorders; Methionine; Middle Aged; Mutation; Phenotype; Positron-Emission Tomography; Presenilin-1	2010
Fasting and post-methionine homocysteine levels in Alzheimers disease and vascular dementia. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2009, Volume: 79, Issue:3 Topics: Aged; Alzheimer Disease; Case-Control Studies; Cohort Studies; Dementia, Vascular; Fasting; Female; Folic Acid; Homocysteine; Humans; Male; Methionine; Statistics, Nonparametric; Vitamin B 12	2009
Clinical features of rapidly progressive Alzheimer's disease. Dementia and geriatric cognitive disorders, 2010, Volume: 29, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Apolipoproteins E; Biomarkers; Codon; Disease Progression; Female; Gait; Gene Frequency; Heterozygote; Homozygote; Humans; Male; Methionine; Middle Aged; Muscle Rigidity; Myoclonus; Peptide Fragments; Polymorphism, Genetic; Prion Proteins; Prions; Retrospective Studies; Survival Analysis; tau Proteins; Time Factors; Valine	2010
Severe In vivo hyper-homocysteinemia is not associatedwith elevation of amyloid-beta peptides in the Tg2576 mice. Journal of Alzheimer's disease : JAD, 2010, Volume: 21, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Humans; Hyperhomocysteinemia; Methionine; Mice; Mice, Transgenic; Peptide Fragments; Random Allocation; Vitamin B 12	2010
Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease. Neuroreport, 2010, Aug-23, Volume: 21, Issue:12 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Basal Metabolism; Brain; Brain Mapping; Brain-Derived Neurotrophic Factor; Cognition Disorders; Female; Genetic Carrier Screening; Genetic Predisposition to Disease; Humans; Male; Methionine; Middle Aged; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Valine	2010
Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine. Journal of neurochemistry, 2011, Volume: 116, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Humans; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Vitamin B Deficiency	2011
Time course of glucose metabolism in relation to cognitive performance and postmortem neuropathology in Met146Val PSEN1 mutation carriers. Journal of Alzheimer's disease : JAD, 2011, Volume: 24, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Mapping; Cognition Disorders; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Mental Status Schedule; Methionine; Middle Aged; Mutation; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Postmortem Changes; Presenilin-1; Statistics as Topic; Time Factors; Valine	2011
Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex. Journal of Alzheimer's disease : JAD, 2012, Volume: 28, Issue:2 Topics: Alzheimer Disease; Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Clorgyline; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hydroxyindoleacetic Acid; Inositol 1,4,5-Trisphosphate Receptors; Methionine; Mice; Mice, Transgenic; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutation; Neuroblastoma; Neurons; Neurotransmitter Agents; Organic Chemicals; Presenilin-1; Serotonin; Subcellular Fractions; Swimming; Transfection; Valine; Voltage-Dependent Anion Channels	2012
Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo. Biochemistry, 2011, Dec-13, Volume: 50, Issue:49 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Female; Hippocampus; Methionine; Methionine Sulfoxide Reductases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Neuroprotective Agents; Oxidation-Reduction; Rats; Rats, Sprague-Dawley	2011
Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease. The Biochemical journal, 2012, Mar-15, Volume: 442, Issue:3 Topics: Alzheimer Disease; Animals; Antioxidants; Apolipoproteins D; CHO Cells; Cricetinae; HEK293 Cells; Hippocampus; Humans; Hydroxyeicosatetraenoic Acids; Methionine; Oxidation-Reduction	2012
Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alz Antioxidants & redox signaling, 2012, Dec-01, Volume: 17, Issue:11 Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Humans; Leucine; Methionine; Mice; Mice, Transgenic; Molecular Sequence Data; Oxidative Stress; Proteins; Proteomics	2012
Autosomal dominant Alzheimer's disease with early frontal lobe involvement associated with the Met239Ile mutation of Presenilin 2 gene. Journal of Alzheimer's disease : JAD, 2012, Volume: 31, Issue:1 Topics: Alzheimer Disease; Cognition Disorders; DNA Mutational Analysis; Family Health; Female; Genetic Association Studies; Humans; Isoleucine; Language Disorders; Magnetic Resonance Imaging; Methionine; Middle Aged; Mutation; Presenilin-2; Tomography, Emission-Computed, Single-Photon	2012
COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures. Neurology, 2012, May-22, Volume: 78, Issue:21 Topics: Aged; Alleles; Alzheimer Disease; Catechol O-Methyltransferase; Cerebral Cortex; Dementia; Dopamine; Female; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Genotype; Humans; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Polymorphism, Single Nucleotide; Prefrontal Cortex; Valine	2012
Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations. Dementia and geriatric cognitive disorders, 2012, Volume: 33, Issue:4 Topics: Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Apolipoproteins E; Blood Proteins; Blotting, Western; DNA; Female; Genotype; Humans; Isoprostanes; Male; Methionine; Mutation; Oxidative Stress; Presenilin-1; Superoxide Dismutase; Superoxide Dismutase-1	2012
Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients. Journal of Alzheimer's disease : JAD, 2012, Volume: 32, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Catechol O-Methyltransferase; Cognitive Dysfunction; Female; Genetic Predisposition to Disease; Humans; Italy; Male; Methionine; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk Factors; Valine	2012
Total ApoE and ApoE4 isoform assays in an Alzheimer's disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides. Molecular & cellular proteomics : MCP, 2012, Volume: 11, Issue:11 Topics: Alzheimer Disease; Amino Acid Sequence; Apolipoprotein E4; Calibration; Case-Control Studies; Cohort Studies; Humans; Hydrolysis; Mass Spectrometry; Methionine; Molecular Sequence Data; Oxidation-Reduction; Peptides; Pilot Projects; Principal Component Analysis; Protein Isoforms; Reproducibility of Results; Time Factors	2012
Methionine 35 oxidation reduces fibril assembly of the amyloid abeta-(1-42) peptide of Alzheimer's disease. The Journal of biological chemistry, 2002, Oct-25, Volume: 277, Issue:43 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Circular Dichroism; Humans; Methionine; Microscopy, Atomic Force; Oxidation-Reduction; Peptide Fragments; Protein Structure, Secondary; Spectrometry, Fluorescence	2002
The radical model of Alzheimer's disease: specific recognition of Gly29 and Gly33 by Met35 in a beta-sheet model of Abeta: an ONIOM study. Journal of Alzheimer's disease : JAD, 2002, Volume: 4, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Free Radicals; Glycine; Humans; Hydrogen Peroxide; Lipid Peroxidation; Methionine; Models, Chemical; Neurofibrillary Tangles; Neurons; Oxidative Stress; Peptides; Reactive Oxygen Species	2002
Early-onset Alzheimer's disease with presenilin-1 M139V mutation: clinical, neuropsychological and neuropathological study. European journal of neurology, 2003, Volume: 10, Issue:3 Topics: Alzheimer Disease; Cerebellar Cortex; Cerebral Cortex; Humans; Male; Membrane Proteins; Methionine; Middle Aged; Mutation; Phenotype; Presenilin-1; Thalamus; Valine	2003
Absence of association between codon 129/219 polymorphisms of the prion protein gene and Alzheimer's disease in Japan. Annals of neurology, 2003, Volume: 54, Issue:4 Topics: Aged; Alzheimer Disease; Amyloid; Case-Control Studies; Codon; Female; Gene Frequency; Genotype; Humans; Japan; Male; Methionine; Polymorphism, Genetic; Prion Proteins; Prions; Protein Precursors; Valine	2003
Free radical reactions of methionine in peptides: mechanisms relevant to beta-amyloid oxidation and Alzheimer's disease. Journal of the American Chemical Society, 2003, Nov-12, Volume: 125, Issue:45 Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Electrochemistry; Free Radicals; Hydrogen-Ion Concentration; Methionine; Peptide Fragments; Spectrophotometry, Ultraviolet	2003
Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology, 2004, Volume: 49, Issue:1 Topics: Age of Onset; Aged; Alleles; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Case-Control Studies; DNA Mutational Analysis; Female; Gene Frequency; Humans; Male; Methionine; Polymorphism, Genetic; Valine	2004
Methionine 35 oxidation reduces toxic effects of the amyloid beta-protein fragment (31-35) on human red blood cell. The international journal of biochemistry & cell biology, 2004, Volume: 36, Issue:10 Topics: Alzheimer Disease; Amyloid beta-Peptides; Catalase; Erythrocytes; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Glutathione Reductase; Hemoglobins; Humans; Kinetics; Methionine; Oxidation-Reduction; Peptide Fragments; Phosphofructokinases	2004
Rodent Abeta(1-42) exhibits oxidative stress properties similar to those of human Abeta(1-42): Implications for proposed mechanisms of toxicity. Journal of Alzheimer's disease : JAD, 2004, Volume: 6, Issue:5 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Free Radical Scavengers; Humans; Lipid Bilayers; Methionine; Molecular Sequence Data; Neurons; Oxidative Stress; Peptide Fragments; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2004
Pick bodies in a family with presenilin-1 Alzheimer's disease. Annals of neurology, 2005, Volume: 57, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blotting, Western; DNA Mutational Analysis; Family Health; Female; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Leucine; Male; Membrane Proteins; Methionine; Middle Aged; Mutation; Neurofibrillary Tangles; Pick Disease of the Brain; Plaque, Amyloid; Postmortem Changes; Presenilin-1; tau Proteins	2005
Methionine regulates copper/hydrogen peroxide oxidation products of Abeta. Journal of peptide science : an official publication of the European Peptide Society, 2005, Volume: 11, Issue:6 Topics: Alzheimer Disease; Amino Acids; Amyloid beta-Peptides; Catalysis; Copper; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Methionine; Oxidation-Reduction; Peptide Fragments; Spectrometry, Fluorescence; Spectrometry, Mass, Electrospray Ionization	2005
One-electron oxidation of beta-amyloid peptide: sequence modulation of reactivity. Free radical biology & medicine, 2004, Sep-15, Volume: 37, Issue:6 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Azides; Chromatography, High Pressure Liquid; Dimerization; Dose-Response Relationship, Radiation; Electrons; Electrophoresis, Polyacrylamide Gel; Free Radicals; Gamma Rays; Humans; Hydrogen Peroxide; Ions; Mass Spectrometry; Methionine; Models, Chemical; Molecular Sequence Data; Oxidation-Reduction; Oxygen; Peptide Fragments; Peptides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry; Spectrum Analysis, Raman; Trypsin; Tyrosine	2004
Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society, 2005, Volume: 20, Issue:8 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Cysteine; Female; Genetic Predisposition to Disease; Humans; Japan; Male; Methionine; Middle Aged; Multiple System Atrophy; Parkinson Disease; Polymorphism, Genetic; Threonine; Valine	2005
Abeta(31-35) peptide induce apoptosis in PC 12 cells: contrast with Abeta(25-35) peptide and examination of underlying mechanisms. Neurochemistry international, 2005, Volume: 46, Issue:7 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Caspase 3; Caspases; Cell Survival; DNA Fragmentation; Methionine; Nerve Degeneration; Neurons; Oxidation-Reduction; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats	2005
Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression. Neuroscience letters, 2005, May-13, Volume: 379, Issue:3 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Black People; Brain-Derived Neurotrophic Factor; Case-Control Studies; Disease Progression; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Methionine; Polymorphism, Genetic; Risk; Valine; White People	2005
The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples. Molecular psychiatry, 2005, Volume: 10, Issue:9 Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Brain-Derived Neurotrophic Factor; Brazil; Case-Control Studies; China; Humans; Italy; Methionine; Polymorphism, Single Nucleotide; Reference Values; Spain; Valine; White People	2005
Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease. Journal of the American Chemical Society, 2005, Nov-02, Volume: 127, Issue:43 Topics: Alzheimer Disease; Amyloid beta-Peptides; Cations; Electron Spin Resonance Spectroscopy; Free Radicals; Kinetics; Methionine; Models, Biological; Models, Molecular; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Peptides; Sulfhydryl Compounds; Tyrosine	2005
Homocysteine and cognition--no longer a hypothesis? Medical hypotheses, 2006, Volume: 66, Issue:3 Topics: Aged; Alzheimer Disease; Cognition; Cognition Disorders; Homocysteine; Humans; Methionine; Models, Biological; Models, Theoretical; Neurodegenerative Diseases; Vitamin B 12; Vitamins	2006
Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35. Biochemical and biophysical research communications, 2006, Mar-31, Volume: 342, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; bcl-2-Associated X Protein; Caspase 3; Caspases; Cell Death; Gene Expression Regulation; Humans; Methionine; Mitochondria; Neuroblastoma; Peptide Fragments; Proto-Oncogene Proteins c-bcl-2	2006
Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. The Journal of biological chemistry, 2006, Apr-21, Volume: 281, Issue:16 Topics: 2,4-Dinitrophenol; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Blotting, Western; Brain; Carbon; Cerebral Cortex; Dimerization; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Intracellular Signaling Peptides and Proteins; Isoelectric Point; Lipid Peroxidation; Lipids; Male; Mass Spectrometry; Methionine; Middle Aged; Molecular Sequence Data; Neurodegenerative Diseases; Oncogene Proteins; Oxidative Stress; Oxygen; Parkinson Disease; Peptides; Protein Deglycase DJ-1; Protein Isoforms; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors	2006
The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2006, Volume: 9, Issue:1 Topics: Aged; Alzheimer Disease; Amino Acid Substitution; Brain-Derived Neurotrophic Factor; Cohort Studies; Female; Humans; Longitudinal Studies; Male; Methionine; Middle Aged; Polymorphism, Single Nucleotide; Valine	2006
Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease. Neurobiology of aging, 2007, Volume: 28, Issue:8 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Catechol O-Methyltransferase; Chi-Square Distribution; Cognition; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Male; Methionine; Neuropsychological Tests; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Psychotic Disorders; Risk; Valine	2007
Computational studies of Cu(II)/Met and Cu(I)/Met binding motifs relevant for the chemistry of Alzheimer's disease. The journal of physical chemistry. A, 2005, Jun-23, Volume: 109, Issue:24 Topics: Alzheimer Disease; Amides; Amino Acid Motifs; Binding Sites; Computer Simulation; Copper; Ions; Ligands; Methionine; Models, Molecular; Nitrogen; Peptides; Thermodynamics	2005
Folate, the methionine cycle, and Alzheimer's disease. Journal of Alzheimer's disease : JAD, 2006, Volume: 9, Issue:4 Topics: Alzheimer Disease; Brain; Folic Acid Deficiency; Homocysteine; Humans; Methionine; Reactive Oxygen Species; S-Adenosylmethionine	2006
Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease. Neurobiology of disease, 2006, Volume: 24, Issue:2 Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Brain-Derived Neurotrophic Factor; DNA Mutational Analysis; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Haplotypes; Huntington Disease; Introns; Methionine; Polymorphism, Single Nucleotide; Trinucleotide Repeat Expansion; Valine	2006
alphaB-crystallin competes with Alzheimer's disease beta-amyloid peptide for peptide-peptide interactions and induces oxidation of Abeta-Met35. FEBS letters, 2006, Oct-30, Volume: 580, Issue:25 Topics: alpha-Crystallin B Chain; Alzheimer Disease; Amyloid beta-Peptides; Binding, Competitive; Circular Dichroism; Humans; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Methionine; Multiprotein Complexes; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Protein Binding; Recombinant Proteins	2006
Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP(714-723). Neuroscience, 2007, Jan-19, Volume: 144, Issue:2 Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Case-Control Studies; Cell Differentiation; Cells, Cultured; Deferoxamine; Dose-Response Relationship, Drug; Estradiol; Female; Glutathione; Glycine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Melatonin; Methionine; Middle Aged; Peptides; Protein Binding; Rats; Temporal Lobe; Valine	2007
Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy. Neurobiology of aging, 2008, Volume: 29, Issue:3 Topics: Alzheimer Disease; Aneuploidy; Animals; Cells, Cultured; Chromosome Segregation; Humans; Lysine; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Platelet-Derived Growth Factor; Presenilin-1; Spindle Apparatus; Spleen; Transfection; Valine	2008
Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation. Neuroreport, 2007, Apr-16, Volume: 18, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Cerebral Cortex; Dimerization; Female; Mass Spectrometry; Methionine; Mice; Mice, Inbred C57BL; Neurons; Oxidation-Reduction; Peptide Fragments; Pregnancy; Sulfoxides	2007
Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population. Neuropsychobiology, 2007, Volume: 55, Issue:3-4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Brain-Derived Neurotrophic Factor; Chi-Square Distribution; China; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Humans; Male; Methionine; Middle Aged; Polymorphism, Genetic; Valine	2007
Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer's and Parkinson's diseases. Acta neurobiologiae experimentalis, 2007, Volume: 67, Issue:2 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cysteine; Deoxyguanosine; DNA Damage; DNA Mutational Analysis; Female; Homocystine; Humans; Male; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Parkinson Disease; Polymorphism, Genetic; Sulfhydryl Compounds; Tetrahydrofolates	2007
Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia. Neuroscience letters, 2008, May-09, Volume: 436, Issue:2 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Attention; Catechol O-Methyltransferase; Cognition Disorders; Genetic Predisposition to Disease; Genotype; Geriatric Assessment; Humans; Male; Methionine; Neuropsychological Tests; Polymorphism, Genetic; Problem Solving; Psychomotor Performance; Valine	2008
Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients? Clinical biochemistry, 2008, Volume: 41, Issue:10-11 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Sensitivity and Specificity	2008
[Cognitive function, serum BDNF levels and BDNF gene Val66Met polymorphism in amnestic mild cognitive impairment]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2008, Volume: 33, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amnesia; Brain-Derived Neurotrophic Factor; Cognition Disorders; Female; Humans; Male; Methionine; Polymorphism, Genetic; Valine	2008
Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: implications for potent neurotoxicity through the formation of radicals. Bioorganic & medicinal chemistry letters, 2008, Jun-01, Volume: 18, Issue:11 Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Free Radicals; Methionine; Models, Biological; Models, Molecular; Neurotoxicity Syndromes; Nuclear Magnetic Resonance, Biomolecular; Oxidative Stress; Peptide Fragments; Protein Structure, Secondary	2008
The amyloid peptide of Alzheimer's disease is not produced by internal initiation of translation generating C-terminal amyloidogenic fragments of its precursor. Neuroscience letters, 1994, Dec-05, Volume: 182, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; CHO Cells; Cricetinae; DNA, Complementary; Humans; Immunoblotting; Methionine	1994
Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. Journal of neurochemistry, 1995, Volume: 64, Issue:1 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Electrophoresis, Polyacrylamide Gel; Methionine; Molecular Sequence Data; Neurons; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	1995
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. The Journal of biological chemistry, 1995, Mar-17, Volume: 270, Issue:11 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anti-Bacterial Agents; Cell Line; Cell Membrane; Cells, Cultured; DNA, Complementary; Fibroblasts; Humans; Kidney; Kinetics; Macrolides; Methionine; Molecular Sequence Data; Mutation; Phenylalanine; Protein Processing, Post-Translational; Proton-Translocating ATPases; Recombinant Proteins; Reference Values; Skin; Sulfur Radioisotopes; Sulfuric Acid Esters; Sweden; Transfection; Vacuoles; Valine	1995
Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proceedings of the National Academy of Sciences of the United States of America, 1994, Dec-06, Volume: 91, Issue:25 Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cells, Cultured; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Genotype; Humans; Kidney; Methionine; Phenylalanine; Point Mutation; Skin; Sulfur Radioisotopes; Sweden; Tritium	1994
Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. The EMBO journal, 1994, Mar-01, Volume: 13, Issue:5 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cell Cycle; Electrophoresis, Gel, Two-Dimensional; G2 Phase; HeLa Cells; Humans; Kinetics; Methionine; Mitosis; Molecular Sequence Data; PC12 Cells; Peptide Mapping; Peptides; Phosphates; Phosphopeptides; Phosphorylation; Threonine	1994
Aluminium and Alzheimer's disease: electrophoresis of proteins from aluminium-treated human neuroblastoma cells. Biochemical Society transactions, 1993, Volume: 21 ( Pt 3), Issue:3 Topics: Aluminum; Alzheimer Disease; Autoradiography; Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Methionine; Neoplasm Proteins; Neuroblastoma; Sulfur Radioisotopes; Tumor Cells, Cultured	1993
Heat-shocked neuronal PC12 cells reveal Alzheimer's disease--associated alterations in amyloid precursor protein and tau. Annals of the New York Academy of Sciences, 1993, Sep-24, Volume: 695 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Heat-Shock Proteins; Hot Temperature; Humans; Methionine; Nerve Growth Factors; Neurons; PC12 Cells; tau Proteins	1993
Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A. The Journal of biological chemistry, 1996, Mar-08, Volume: 271, Issue:10 Topics: Alzheimer Disease; Amino Acid Sequence; Antibodies; Autoradiography; Blotting, Western; Cells, Cultured; Colchicine; Electrophoresis, Polyacrylamide Gel; Epitopes; Humans; Methionine; Microtubules; Neurons; Nocodazole; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Protein Phosphatase 2; Serine; Sulfur Radioisotopes; tau Proteins; Teratocarcinoma; Threonine; Tumor Cells, Cultured	1996
Combined study of cerebral glucose metabolism and [11C]methionine accumulation in probable Alzheimer's disease using positron emission tomography. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:3 Topics: Aged; Alzheimer Disease; Brain; Carbon Radioisotopes; Female; Glucose; Humans; Male; Methionine; Middle Aged; Models, Biological; Psychiatric Status Rating Scales; Severity of Illness Index; Tissue Distribution; Tomography, Emission-Computed	1996
On the mechanism of the inhibition of glutamine synthetase and creatine phosphokinase by methionine sulfoxide. Journal of neuroscience research, 1996, Jan-01, Volume: 43, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Ascorbic Acid; Catalase; Cattle; Creatine Kinase; Enzyme Inhibitors; Free Radicals; Glutamate-Ammonia Ligase; Methionine; Nerve Tissue Proteins; Oxidation-Reduction; Peptide Fragments; Protein Denaturation; Serum Albumin, Bovine; Sheep; Superoxide Dismutase	1996
Familial Alzheimer's disease co-segregates with a Met146I1e substitution in presenilin-1. Clinical genetics, 1996, Volume: 50, Issue:5 Topics: Adult; Aged; Alzheimer Disease; Female; Humans; Isoleucine; Male; Membrane Proteins; Methionine; Pedigree; Presenilin-1	1996
Presenilin 1 Met146Leu variant due to an A --> T transversion in an early-onset familial Alzheimer's disease pedigree from Argentina. Clinical genetics, 1998, Volume: 53, Issue:6 Topics: Adenine; Adult; Age of Onset; Alzheimer Disease; Amino Acid Substitution; Argentina; Female; Genetic Variation; Humans; Leucine; Male; Membrane Proteins; Methionine; Middle Aged; Pedigree; Presenilin-1; Thymine	1998
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiology of disease, 1998, Volume: 5, Issue:2 Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Line; Gene Expression Regulation; Humans; Leucine; Membrane Proteins; Methionine; Mutagenesis, Site-Directed; Peptide Fragments; Presenilin-1; Valine	1998
Pulse-chase experiments revealed beta-secretase cleavage from immature full-length amyloid precursor protein harboring the Swedish mutation. Implications for distinct pathways. Journal of molecular neuroscience : MN, 1998, Volume: 11, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Brefeldin A; Cell Compartmentation; Endopeptidases; Glycosylation; Golgi Apparatus; Humans; Ionophores; Methionine; Monensin; Mutagenesis; Neuroblastoma; Peptide Fragments; Plasmids; Protein Synthesis Inhibitors; Sulfur Radioisotopes; Transfection; Tumor Cells, Cultured	1998
Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America, 1999, Mar-30, Volume: 96, Issue:7 Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Line; Female; Humans; Male; Methionine; Mutagenesis, Site-Directed; Pedigree; Phenotype; Point Mutation; Recombinant Proteins; Transfection; Valine	1999
Methodological and chemical factors affecting amyloid beta peptide amyloidogenicity. Methods in enzymology, 1999, Volume: 309 Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Magnetic Resonance Spectroscopy; Metals; Methionine; Oxidation-Reduction; Peptide Fragments; Protein Conformation; Stereoisomerism; Time Factors	1999
Examination of the interactions of the amyloid precursor protein carboxyl terminus to intracellular protein: possible role in apoptosis. Progress in neuro-psychopharmacology & biological psychiatry, 1999, Volume: 23, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Brain Neoplasms; Electrophoresis, Polyacrylamide Gel; Hippocampus; Humans; In Vitro Techniques; Iodine Radioisotopes; Methionine; Mice; Nerve Degeneration; Neuroblastoma; Peptide Fragments; Sulfur Radioisotopes; Tumor Cells, Cultured	1999
Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress. Brain research bulletin, 1999, Sep-15, Volume: 50, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Fetus; Free Radicals; Methionine; Neurons; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Spin Trapping; Tetrazolium Salts; Trypan Blue	1999
Pacifichem 2000: Pacific chemists throw switches, strike at disease. Science (New York, N.Y.), 2001, Jan-19, Volume: 291, Issue:5503 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Caenorhabditis elegans; Cells, Cultured; Computing Methodologies; Electrochemistry; Electrodes; Free Radicals; Humans; Methionine; Neurons; Rats; Societies, Scientific; Vitamin E	2001
Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta(1--42) and A beta(25--35). Journal of the American Chemical Society, 2001, Jun-20, Volume: 123, Issue:24 Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Cell Culture Techniques; Cell Death; Electron Spin Resonance Spectroscopy; Humans; Methionine; Microscopy, Electron; Molecular Sequence Data; Nerve Degeneration; Neurons; Oxidation-Reduction; Oxidative Stress; Peptide Fragments; Proteins; Rats; Rats, Sprague-Dawley	2001
Abnormal expression of actin in lymphocytes of Alzheimer's disease and Down's syndrome patients. Journal of neuroimmunology, 1992, Volume: 38, Issue:3 Topics: Actins; Aged; Aged, 80 and over; Alzheimer Disease; Culture Media; Down Syndrome; Electrophoresis, Gel, Two-Dimensional; Female; Humans; Immunoblotting; Lymphocytes; Male; Methionine; Middle Aged; Peptide Mapping	1992
Slowed synthesis of DNA and methionine is a pathogenetic mechanism common to dementia in Down's syndrome, AIDS and Alzheimer's disease? Medical hypotheses, 1992, Volume: 38, Issue:1 Topics: AIDS Dementia Complex; Alzheimer Disease; Amyloidosis; Cell Death; Dementia; DNA; DNA Repair; DNA Replication; Down Syndrome; Humans; Methionine; Models, Biological	1992
Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain research. Molecular brain research, 1991, Volume: 10, Issue:2 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoradiography; Cerebral Cortex; Choline O-Acetyltransferase; Electrophoresis, Gel, Two-Dimensional; Humans; Male; Methionine; N-Methylaspartate; Polyribosomes; Protein Biosynthesis; Protein Precursors; Rats; Rats, Inbred Strains; Substantia Innominata; Sulfur Radioisotopes	1991
Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease. Brain research. Molecular brain research, 1991, Volume: 11, Issue:3-4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cerebellum; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Heat-Shock Proteins; Humans; Immunoblotting; Methionine; Molecular Weight; Polyribosomes; Reference Values; Sulfur Radioisotopes; Temporal Lobe	1991
Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:15 Topics: Adrenal Gland Neoplasms; Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Cell Line; Ethers, Cyclic; Humans; Kinetics; Methionine; Molecular Weight; Okadaic Acid; Pheochromocytoma; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Biosynthesis; Protein Kinase C; Protein Precursors; Protein Processing, Post-Translational; Tetradecanoylphorbol Acetate; Transcription, Genetic	1990