methimazole has been researched along with Tuberculosis* in 1 studies
1 other study(ies) available for methimazole and Tuberculosis
| Article | Year |
|---|---|
Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug-Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3.
The widely used second-line antituberculosis drug ethionamide shows wide interindividual variability in its disposition; however, the relevant factors affecting this phenomenon have not been characterized. We previously reported the major contribution of flavin-containing monooxygenase 3 (FMO3) in the reductive elimination pathway of ethionamide. In this study, ethionamide metabolism was potentially inhibited by methimazole in vitro. The drug-drug interaction leading to methimazole affecting the disposition of ethionamide mediated by FMO3 was then quantitated using a bottom-up approach with a physiologically based pharmacokinetic framework. The maximum concentration (C Topics: Adult; Antitubercular Agents; Biological Variation, Population; Drug Interactions; Ethionamide; Female; Humans; Liver; Male; Methimazole; Models, Biological; Mutation; Oxygenases; Polymorphism, Genetic; Tuberculosis | 2019 |