methimazole and Prostatic-Hyperplasia

Experimental model of sulpiride-provoked benign prostatic hyperplasia was employed to comparatively assess the effect of phenolic antioxidants (dihydroquercetin, p-thyrozol, dibornol, and prostagenin) on prostate morphology. All examined agents decreased the degree of hyperplasia in acinar epithelium; the greatest efficacy was demonstrated by prostagenin. Moreover, dihydroquercetin and p-thyrozol increased the cross-section area of acinar lumina and prostate volume, which is inadmissible in this pathology. These results suggest that the use of phenolic antioxidants in the therapy of benign prostatic hyperplasia should be strictly controlled.

Topics: Acinar Cells; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Humans; Male; Methimazole; Organ Size; Phenols; Prostate; Prostatic Hyperplasia; Quercetin; Rats; Sulpiride

Severe cardiovascular events, such as coronary vasospasm or acute myocardial infarction can occur during anaphylactic reactions. Although rare, this cause of ischaemic heart disease is known. We present the case of a patient who suffered an angina episode after an anaphylactic reaction due tot administering metamizole, with no significant lesions observed in the coronary catheterisation.

Topics: Aged, 80 and over; Anaphylaxis; Atrioventricular Block; Coronary Angiography; Coronary Vasospasm; Drug Hypersensitivity; Humans; Hypotension; Male; Methimazole; Postoperative Complications; Prostatic Hyperplasia; Recovery Room; Syndrome; Transurethral Resection of Prostate