methimazole and Pituitary-Diseases

methimazole has been researched along with Pituitary-Diseases* in 2 studies

Other Studies

2 other study(ies) available for methimazole and Pituitary-Diseases

Article	Year
Effective methimazole dose for childhood Graves' disease and use of free triiodothyronine combined with concurrent thyroid-stimulating hormone level to identify mild hyperthyroidism and delayed pituitary recovery. Journal of pediatric endocrinology & metabolism : JPEM, 2005, Volume: 18, Issue:6 Appropriate methimazole dosing for initial treatment of childhood Graves' disease is uncertain. A retrospective chart review was performed on 5 to 17 year-old children treated for Graves' disease. Patients were divided into two groups depending on initial methimazole dosing: low-dose and high-dose regimens using <0.5 mg/kg/day and >0.5 mg/kg/day, respectively. The low-dose regimen was effective in 5/12 (42%) of patients and the high-dose regimen was effective in 27/33 (82%) of patients (p = 0.016). There was also a statistically significant dose/time interaction for levels of free thyroxine (T4) (p = 0.025). During treatment, 63.3% of diagnosable samples showed unambiguous hyperthyroidism or triiodothyronine (T3) toxicosis, 16.7% elevated free T3 with normal free T4 and T3 levels, indicating borderline hyperthyroidism, and 20% showed thyroid-stimulating hormone (TSH) suppression with normal or low levels of free T4 and free T3, indicating delayed recovery of pituitary TSH secretion. Free T3 levels combined with concurrent TSH levels permit differentiation of mild hyperthyroidism from delayed pituitary recovery. Topics: Adolescent; Antithyroid Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Graves Disease; Humans; Hyperthyroidism; Male; Methimazole; Pituitary Diseases; Retrospective Studies; Thyrotoxicosis; Thyrotropin; Thyroxine; Triiodothyronine	2005
A case of autoimmune hypophysitis associated with Graves' disease. Endocrine journal, 2002, Volume: 49, Issue:6 In a 76-year-old woman with hyperthyroidism, hyperprolactinemia and thickening of the pituitary stalk on magnetic resonance imaging (MRI) was presented. Thyroid stimulating antibody (TSAb) was positive and anti-pituitary antibodies against 49 and 68 kD human anterior pituitary membrane antigens were detected immunologically. Secretion of pituitary hormones was almost normal except for suppressed TSH and hyperprolactinemia. As autoimmune etiologies were likely involved in the disorders, autoimmune hypophysitis associated with Graves' disease was arrived at as the plausible diagnosis. Topics: Aged; Antithyroid Agents; Female; Graves Disease; Humans; Hyperprolactinemia; Magnetic Resonance Imaging; Methimazole; Pituitary Diseases; Treatment Outcome	2002

Article

Year

Effective methimazole dose for childhood Graves' disease and use of free triiodothyronine combined with concurrent thyroid-stimulating hormone level to identify mild hyperthyroidism and delayed pituitary recovery.

Journal of pediatric endocrinology & metabolism : JPEM, 2005, Volume: 18, Issue:6

Appropriate methimazole dosing for initial treatment of childhood Graves' disease is uncertain. A retrospective chart review was performed on 5 to 17 year-old children treated for Graves' disease. Patients were divided into two groups depending on initial methimazole dosing: low-dose and high-dose regimens using <0.5 mg/kg/day and >0.5 mg/kg/day, respectively. The low-dose regimen was effective in 5/12 (42%) of patients and the high-dose regimen was effective in 27/33 (82%) of patients (p = 0.016). There was also a statistically significant dose/time interaction for levels of free thyroxine (T4) (p = 0.025). During treatment, 63.3% of diagnosable samples showed unambiguous hyperthyroidism or triiodothyronine (T3) toxicosis, 16.7% elevated free T3 with normal free T4 and T3 levels, indicating borderline hyperthyroidism, and 20% showed thyroid-stimulating hormone (TSH) suppression with normal or low levels of free T4 and free T3, indicating delayed recovery of pituitary TSH secretion. Free T3 levels combined with concurrent TSH levels permit differentiation of mild hyperthyroidism from delayed pituitary recovery.

Topics: Adolescent; Antithyroid Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Graves Disease; Humans; Hyperthyroidism; Male; Methimazole; Pituitary Diseases; Retrospective Studies; Thyrotoxicosis; Thyrotropin; Thyroxine; Triiodothyronine

2005

A case of autoimmune hypophysitis associated with Graves' disease.

Endocrine journal, 2002, Volume: 49, Issue:6

In a 76-year-old woman with hyperthyroidism, hyperprolactinemia and thickening of the pituitary stalk on magnetic resonance imaging (MRI) was presented. Thyroid stimulating antibody (TSAb) was positive and anti-pituitary antibodies against 49 and 68 kD human anterior pituitary membrane antigens were detected immunologically. Secretion of pituitary hormones was almost normal except for suppressed TSH and hyperprolactinemia. As autoimmune etiologies were likely involved in the disorders, autoimmune hypophysitis associated with Graves' disease was arrived at as the plausible diagnosis.

Topics: Aged; Antithyroid Agents; Female; Graves Disease; Humans; Hyperprolactinemia; Magnetic Resonance Imaging; Methimazole; Pituitary Diseases; Treatment Outcome

2002