methimazole and Peripheral-Nervous-System-Neoplasms

According to the data obtained by the authors, some modifying factors, and in particular artificial disorders of hormonal balance in rats, influence the realization of the blastomogenic effect of methylnitrosourea. The results of these studies indicate that the manifestation and the development of tumors in the peripheral nerves occurs more rapidly and easier in experimental hypothyrosis due to a daily administration of anti-thyroid drugs (merkazolyl) and an estrogenation of the organism of animals by a monthly subcutaneous suturation of sinestrol pills. In castration and administration of thyroid hormones (thyroidin) the amount of experimental neurogenic newgrowths decreases with an extension of the latent period of their development.

Topics: Animals; Castration; Female; Gonadal Steroid Hormones; Hexestrol; Homeostasis; Methimazole; Methylnitrosourea; Neoplasms, Experimental; Peripheral Nervous System Neoplasms; Rats; Thyroid Hormones; Time Factors