methimazole and Paraplegia

Typical presentations of hyperthyroidism are palpitation, nervousness, tremor, malaise, and weight loss. Hyperthyroidism affects nearly every system in the body, and some patients may manifest neurologic or hematologic symptoms. Atypical presentations of hyperthyroidism often pose a great challenge in diagnosis and treatment. We report a case of Basedow's paraplegia and pancytopenia that was precipitated by hyperthyroidism. The unusual manifestations led to unnecessary examinations and delayed the treatment of hyperthyroidism. The classical symptoms of Basedow's paraplegia are subacute symmetric weakness of the lower extremities with areflexia and sparing sensation or sphincter involvement. Control of the hyperthyroidism mitigated the neurologic and hematologic complications and prevented unnecessary studies.

Topics: Adrenergic beta-Antagonists; Adult; Antithyroid Agents; Female; Humans; Hyperthyroidism; Methimazole; Pancytopenia; Paraplegia; Propranolol

Topics: Adult; Antithyroid Agents; Graves Disease; Humans; Knee; Male; Methimazole; Muscle Weakness; Paraplegia; Thyroid Function Tests