methimazole and Nephrotic-Syndrome

Nephritis has been rarely associated with methimazole, primarily in the development of nephrotic syndrome. We describe a case of acute kidney injury without evidence of nephrotic syndrome following methimazole initiation.. We present the relevant history, laboratory data, and nuclear medicine data and review relevant documentation from the literature.. A 72-year-old male recently diagnosed with new-onset atrial fibrillation was found to have suppressed thyroid-stimulating hormone (TSH) levels; elevated free T. Acute kidney injury with or without the presence of nephrotic syndrome may occur during treatment with methimazole. Renal function should be closely monitored after the initiation of methimazole to prevent progressive renal dysfunction.

Topics: Acute Kidney Injury; Aged; Antithyroid Agents; Graves Disease; Humans; Male; Methimazole; Nephrotic Syndrome; Propylthiouracil

Topics: Adult; Extremities; Humans; Hyperthyroidism; Male; Methimazole; Nephrotic Syndrome; Paralysis; Periodicity; Recurrence; Remission Induction

Thionamide drugs are widely used in the management of hyperthyroidism and are infrequently associated with adverse reactions. We report the development of the nephrotic syndrome during methimazole (Tapazole) therapy in a young man with Graves' disease. His proteinuria remitted promptly with discontinuance of the drug, and renal histologic features bore a striking resemblance to the toxic nephrosis induced in animals by the aminonucleoside of puromycin. In view of the histologic similarities, we propose that methimazole acted as a direct glomerular toxin, inducing the nephrotic syndrome in this patient.

Topics: Adult; Humans; Hyperthyroidism; Male; Methimazole; Nephrotic Syndrome

Topics: Adult; Female; Humans; Hyperthyroidism; Methimazole; Nephrotic Syndrome

Topics: Adult; Antithyroid Agents; Female; Humans; Hyperthyroidism; Imidazoles; Kidney; Methimazole; Nephrotic Syndrome; Prednisolone