methimazole and Leprosy

Topics: Acetamides; Anemia, Hemolytic; Aniline Compounds; Animals; Clofazimine; Dapsone; Disease Models, Animal; Drug Resistance, Microbial; Drug Therapy, Combination; Humans; Leprosy; Methimazole; Mice; Mycobacterium leprae; Phenyl Ethers; Rifampin; Sulfonamides; Thiosemicarbazones; Thiourea

Topics: Animals; Anti-Bacterial Agents; Antithyroid Agents; Cell Division; Female; Leprostatic Agents; Leprosy; Methimazole; Mice; Mice, Inbred BALB C; Mycobacterium; Mycobacterium leprae; Phenylthiourea; Propylthiouracil; Species Specificity; Thiazoles; Thiones

Multiplication of Mycobacterium leprae in the mouse footpad was inhibited when mice were fed, mixed in their diet, 0.05 per cent methimazole, 0.066 per cent USP thyroid powder, methimazole plus thyroid powder, 0.15 per cent 5-n-heptyl-2-thioxo-4-thiazolidinone, 0.1 per cent propylthiouracil, and 0.1 per cent thambutosine for 154 days, beginning on the day of inoculation. All of the treatment regimens, except for the 2 containing thyroid powder, decreased the plasma concentrations of thyroxine and protein-bound iodine. It is suggested that the 2 antithyroid drugs, methiomazole and propylthiouracil, and the 2 antimicrobial agents, heptylthioxothiazolidinone and thiambutosine, all of which possess structural features in common, may exert the antithyroid and antimicrobial effects through a common mechanisms.

Topics: Aniline Compounds; Animals; Antithyroid Agents; Drug Evaluation; Drug Resistance, Microbial; Leprostatic Agents; Leprosy; Methimazole; Mice; Mycobacterium leprae; Phenyl Ethers; Propylthiouracil; Thiazoles; Thiazolidines; Thiones; Thiourea; Thyroid (USP)

Topics: Animals; Female; Foot; Iodine Isotopes; Leprosy; Methimazole; Mice; Mice, Inbred BALB C; Mycobacterium leprae; Thyroid Function Tests; Thyroid Gland; Thyroxine; Time Factors

Topics: Antithyroid Agents; Bronchitis; Drug Therapy; Humans; Hypothyroidism; Leprosy; Methimazole; Pharmacology; Pulmonary Emphysema; Respiratory Insufficiency; Silicosis; Thyroid Function Tests; Thyroid Gland

Topics: Aminosalicylic Acid; Animals; Anti-Infective Agents; Capreomycin; Drug Combinations; Ethambutol; Griseofulvin; Leprosy; Methimazole; Mice; Oxadiazoles; Pharmacology; Research; Sulfonamides

Topics: Antithyroid Agents; Humans; Leprosy; Methimazole; Physiology; Thyroid Function Tests; Thyroid Gland

Topics: Antithyroid Agents; Leprosy; Methimazole