methimazole and Glioma

methimazole has been researched along with Glioma* in 1 studies

Other Studies

1 other study(ies) available for methimazole and Glioma

Article	Year
Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells. Nuclear medicine and biology, 2002, Volume: 29, Issue:7 The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [(211)At]astatide in the UVW human glioma cell line transfected to express NIS. [(211)At]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [(131)I]iodide uptake. These studies suggest [(211)At]astatide as a possible alternative radionuclide to [(131)I]iodide for NIS-based endoradiotherapy, and provide a model for the study of [(211)At]astatide behavior at a cellular level. Topics: Astatine; Dose-Response Relationship, Drug; Glioma; Humans; Iodine Radioisotopes; Methimazole; Perchlorates; Radiopharmaceuticals; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Sodium Compounds; Symporters; Transfection; Tumor Cells, Cultured	2002

Article

Year

Sodium-iodide symporter (NIS)-mediated accumulation of [(211)At]astatide in NIS-transfected human cancer cells.

Nuclear medicine and biology, 2002, Volume: 29, Issue:7

The cellular expression of the sodium iodide symporter (NIS) has been shown to confer iodide-concentrating capacity in non-thyroid cell types. We examined the role of NIS in the uptake of the alpha-particle emitting radiohalide [(211)At]astatide in the UVW human glioma cell line transfected to express NIS. [(211)At]Astatide uptake is shown to be NIS-dependent, with characteristics similar to [(131)I]iodide uptake. These studies suggest [(211)At]astatide as a possible alternative radionuclide to [(131)I]iodide for NIS-based endoradiotherapy, and provide a model for the study of [(211)At]astatide behavior at a cellular level.

Topics: Astatine; Dose-Response Relationship, Drug; Glioma; Humans; Iodine Radioisotopes; Methimazole; Perchlorates; Radiopharmaceuticals; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Sodium Compounds; Symporters; Transfection; Tumor Cells, Cultured

2002