methimazole and Choriocarcinoma

Extragonadal choriocarcinoma is rare and can be associated with hyperthyroidism when producing very high levels of human chorionic gonadotropin.. Severe thyrotoxicosis can represent an unusual initial presentation of metastatic choriocarcinoma in the setting of extreme elevation of beta-human chorionic gonadotropin. Primary gastric choriocarcinoma is an aggressive malignancy with very poor outcomes. The co-occurrence of severe thyrotoxicosis with advanced primary gastric choriocarcinoma and imminent liver failure complicates management options.

Topics: Choriocarcinoma; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Female; Hepatomegaly; Humans; Hyperthyroidism; Liver Failure; Male; Methimazole; Middle Aged; Neoplasms, Germ Cell and Embryonal; Pregnancy; Stomach Neoplasms; Testicular Neoplasms; Thyrotoxicosis; Tomography, X-Ray Computed

Topics: Adolescent; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Hormones, Ectopic; Humans; Hydatidiform Mole; Hyperthyroidism; Methimazole; Methotrexate; Neoplasm Metastasis; Pregnancy; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine