methimazole and Cholangitis--Sclerosing

Cholestatic jaundice caused by imidazole derivates is a rare complication of antithyroid therapy. Only 20 such cases have been reported in the literature since the introduction of methimazole in 1949 and of carbimazole in 1953. We present a further case of methimazole-induced cholestatic liver injury, mimicking sclerosing cholangitis, where the etiology has been proven by a clear chronological relationship and the lack of other causative factors.

Topics: Adenoma; Aged; Antithyroid Agents; Bile Ducts, Intrahepatic; Chemical and Drug Induced Liver Injury; Cholangiopancreatography, Endoscopic Retrograde; Cholangitis, Sclerosing; Cholestasis, Intrahepatic; Diagnosis, Differential; Humans; Hyperthyroidism; Liver Function Tests; Male; Methimazole; Thyroid Neoplasms