methimazole and Burns

methimazole has been researched along with Burns* in 2 studies

Other Studies

2 other study(ies) available for methimazole and Burns

Article	Year
Induction of hyperthyroidism in burn patients treated topically with povidone-iodine. Burns, including thermal injury, 1988, Volume: 14, Issue:4 Hyperthyroidism was induced in two burn patients (one a 34-year-old male, with burns covering 80 per cent BSA and the other a 22-year-old female with a 45 per cent BSA burn) by topical treatment with povidone-iodine. Both patients had no history of thyroid disease and their post-burn examination revealed normal thyroid glands. In both patients 1 per cent povidone-iodine was applied onto granulation tissue and a marked increase in circulating thyroid hormones occurred. After topical treatment with povidone-iodine was discontinued circulating thyroid hormones returned to normal values within weeks. In the second patient povidone-iodine treatment had to be repeated again resulting in hyperthyroidism which was also readily reversible. Topics: Administration, Topical; Adult; Burns; Female; Humans; Hyperthyroidism; Male; Methimazole; Povidone; Povidone-Iodine; Thyroid Hormones	1988
The use of specific thromboxane inhibitors to preserve the dermal microcirculation after burning. Surgery, 1980, Volume: 87, Issue:2 Selective thromboxane inhibitors were evaluated as a pharmacological agent in the prevention of progressive dermal ischemia after burning. Standardized partial-thickness burns were inflicted on guinea pigs. Burned guinea pigs were separated into four groups: one served as a control, one was treated with Imidazole, one with dipyridamole, and the other with methimazole. Histology and depth of dermal perfusion were evaluated by the India ink perfusion technique. Untreated controls showed progressive dermal ischemia with complete absence of India ink-filled vessels in the dermis by 24 hours. Imidazole, dipyridamole, and methimazole improved dermal perfusion as suggested by relative levels of India Ink filling. Preservation of dermal appendages was seen secondarily to improved dermal microcirculation with an eight-fold increase in hair follicles in treated guinea pigs compared with controls. This study suggest that thromboxane plays a role in progressive dermal ischemia. Selective inhibition of thromboxane avoids the side effects associated with complete suppression of the metabolism of arachidonic acid. Topics: Animals; Burns; Dipyridamole; Female; Guinea Pigs; Heterocyclic Compounds; Imidazoles; Ischemia; Methimazole; Microcirculation; Skin; Thromboxanes	1980

Article

Year

Induction of hyperthyroidism in burn patients treated topically with povidone-iodine.

Burns, including thermal injury, 1988, Volume: 14, Issue:4

Hyperthyroidism was induced in two burn patients (one a 34-year-old male, with burns covering 80 per cent BSA and the other a 22-year-old female with a 45 per cent BSA burn) by topical treatment with povidone-iodine. Both patients had no history of thyroid disease and their post-burn examination revealed normal thyroid glands. In both patients 1 per cent povidone-iodine was applied onto granulation tissue and a marked increase in circulating thyroid hormones occurred. After topical treatment with povidone-iodine was discontinued circulating thyroid hormones returned to normal values within weeks. In the second patient povidone-iodine treatment had to be repeated again resulting in hyperthyroidism which was also readily reversible.

Topics: Administration, Topical; Adult; Burns; Female; Humans; Hyperthyroidism; Male; Methimazole; Povidone; Povidone-Iodine; Thyroid Hormones

1988

The use of specific thromboxane inhibitors to preserve the dermal microcirculation after burning.

Surgery, 1980, Volume: 87, Issue:2

Selective thromboxane inhibitors were evaluated as a pharmacological agent in the prevention of progressive dermal ischemia after burning. Standardized partial-thickness burns were inflicted on guinea pigs. Burned guinea pigs were separated into four groups: one served as a control, one was treated with Imidazole, one with dipyridamole, and the other with methimazole. Histology and depth of dermal perfusion were evaluated by the India ink perfusion technique. Untreated controls showed progressive dermal ischemia with complete absence of India ink-filled vessels in the dermis by 24 hours. Imidazole, dipyridamole, and methimazole improved dermal perfusion as suggested by relative levels of India Ink filling. Preservation of dermal appendages was seen secondarily to improved dermal microcirculation with an eight-fold increase in hair follicles in treated guinea pigs compared with controls. This study suggest that thromboxane plays a role in progressive dermal ischemia. Selective inhibition of thromboxane avoids the side effects associated with complete suppression of the metabolism of arachidonic acid.

Topics: Animals; Burns; Dipyridamole; Female; Guinea Pigs; Heterocyclic Compounds; Imidazoles; Ischemia; Methimazole; Microcirculation; Skin; Thromboxanes

1980