methimazole and Acute-Kidney-Injury

Topics: Acetazolamide; Acute Kidney Injury; Anuria; Back Pain; Diagnosis, Differential; Fluid Therapy; Furosemide; Humans; Macular Degeneration; Male; Meperidine; Methimazole; Middle Aged; Thrombosis; Ureteral Obstruction; Urethral Obstruction

Nephritis has been rarely associated with methimazole, primarily in the development of nephrotic syndrome. We describe a case of acute kidney injury without evidence of nephrotic syndrome following methimazole initiation.. We present the relevant history, laboratory data, and nuclear medicine data and review relevant documentation from the literature.. A 72-year-old male recently diagnosed with new-onset atrial fibrillation was found to have suppressed thyroid-stimulating hormone (TSH) levels; elevated free T. Acute kidney injury with or without the presence of nephrotic syndrome may occur during treatment with methimazole. Renal function should be closely monitored after the initiation of methimazole to prevent progressive renal dysfunction.

Topics: Acute Kidney Injury; Aged; Antithyroid Agents; Graves Disease; Humans; Male; Methimazole; Nephrotic Syndrome; Propylthiouracil

Topics: Acute Kidney Injury; Anti-Bacterial Agents; Antithyroid Agents; Ceftazidime; Clindamycin; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Methimazole; Middle Aged; Salmonella enterica; Salmonella Infections; Thyroiditis, Suppurative

Clinical recognition of drug-induced vasculitic and lupus-like syndromes is very important because continued use of the offending drug can lead to irreversible and life-threatening vasculitic organ damage (e.g. end-stage renal disease or pulmonary haemorrhage). Withdrawal of the drug often leads to spontaneous recovery, meaning that immunosuppressive therapy can be avoided. The presence of myeloperoxidase-antineutrophil cytoplasmic antibodies, IgM anticardiolipin antibody, and antihistone antibodies in combination was found to be characteristic of drug-induced vasculitic syndromes caused by the antithyroid drugs propylthiouracil and methimazol. Clinically, skin vasculitis and arthralgias predominated and renal vasculitis was rare.

Topics: Acute Kidney Injury; Antibodies, Anticardiolipin; Antibodies, Antineutrophil Cytoplasmic; Antithyroid Agents; Autoantibodies; Autoimmune Diseases; Churg-Strauss Syndrome; Diagnosis, Differential; Granulomatosis with Polyangiitis; Humans; Immunoglobulin M; Kidney; Lupus Erythematosus, Systemic; Methimazole; Propylthiouracil; Skin; Thrombophilia; Vasculitis, Leukocytoclastic, Cutaneous