methimazole and Abnormalities--Multiple

methimazole has been researched along with Abnormalities--Multiple* in 8 studies

Other Studies

8 other study(ies) available for methimazole and Abnormalities--Multiple

ArticleYear
A case of Mayer-Rokitansky-Küster-Hauser syndrome presenting as Graves disease.
    Journal of pediatric endocrinology & metabolism : JPEM, 2012, Volume: 25, Issue:11-12

    The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital disorder characterized by aplasia of the uterus and the upper part of the vagina in an XX individual with normal development of secondary sexual characteristics. Individuals with this syndrome may also present with renal and skeletal abnormalities. We report a case of a 16-year-old girl presenting with thyrotoxicosis and primary amenorrhea. After being diagnosed with Graves disease, this patient was placed on antithyroid medication. Although her thyroid function normalized, she did not start to menstruate. Therefore, we assessed her primary amenorrhea and diagnosed the patient with MRKH syndrome through pelvic imaging. To our knowledge, an association between Graves disease and MRKH syndrome has not yet been reported.

    Topics: 46, XX Disorders of Sex Development; Abnormalities, Multiple; Adolescent; Amenorrhea; Antithyroid Agents; Congenital Abnormalities; Diagnosis, Differential; Female; Graves Disease; Humans; Kidney; Methimazole; Mullerian Ducts; Pelvis; Somites; Spine; Thyrotoxicosis; Tomography, X-Ray Computed; Uterus; Vagina

2012
Methimazole embryopathy: a contribution to defining the phenotype.
    Reproductive toxicology (Elmsford, N.Y.), 2007, Volume: 23, Issue:2

    It has been suggested that children prenatally exposed to methimazole may present some features in common but the phenotype remains to be defined. The reported facial features include upward slanted palpebral fissures, arched flared eyebrows and small nose with a broad bridge. Choanal atresia and other anomalies like esophageal atresia and aplasia cutis were also described with this embryopathy. Additionally, developmental delay was reported in some patients along with one of these major malformation. We present a patient with the mentioned facial features, developmental delay and radio-ulnar synostosis whose mother has been exposed to methimazole during pregnancy and any other ethiological cause could be recognize.

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antithyroid Agents; Facies; Humans; Infant; Male; Methimazole; Phenotype; Radiography; Radius; Synostosis; Ulna

2007
Gastrointestinal malformations in two infants born to women with hyperthyroidism untreated in the first trimester.
    American journal of perinatology, 2003, Volume: 20, Issue:2

    We report two infants with gastrointestinal anomalies: one with esophageal atresia and tracheo-esophageal fistula and the other with biliary tree atresia, born to hyperthyroid women diagnosed and treated with methimazole after 14 weeks' gestation. Euthyroidism was documented in both infants. These cases raise the issue of whether untreated hyperthyroidism and not methimazole intake is the teratogen.

    Topics: Abnormalities, Multiple; Adolescent; Adult; Antithyroid Agents; Biliary Atresia; Digestive System; Digestive System Abnormalities; Esophageal Atresia; Female; Humans; Hyperthyroidism; Infant, Newborn; Methimazole; Pregnancy; Pregnancy Complications; Time Factors; Tracheoesophageal Fistula; Treatment Outcome

2003
An autosomal recessive syndrome of choanal atresia, hypothelia/athelia and thyroid gland anomalies overlapping bamforth syndrome, ANOTHER syndrome and methimazole embryopathy.
    Clinical dysmorphology, 2002, Volume: 11, Issue:2

    Two sibs from an inbred Arab family are described with an autosomal syndrome of choanal atresia, hypothelia/athelia and thyroid gland anomalies overlapping Bamforth syndrome, ANOTHER syndrome and methimazole embryopathy. In one case the syndrome described was lethal. Cases with similar features are reviewed and genetic mutations discussed.

    Topics: Abnormalities, Multiple; Child, Preschool; Choanal Atresia; Congenital Hypothyroidism; Facies; Female; Genes, Recessive; Humans; Infant; Infant, Newborn; Male; Methimazole; Nipples; Syndrome; Thyroid Gland

2002
[Bilateral renal agenesis (Potter's syndrome) in a girl born to a hyperthyroid mother who received methimazole in early pregnancy].
    Ginecologia y obstetricia de Mexico, 1999, Volume: 67

    Bilateral kidney agenesias (Potter syndrome) in a newborn of a hyperthyroid woman receiving methimazole during early pregnancy. This is a clinical case of a hyperthyroid woman that received methimazole during early pregnancy who gave birth to a girl with bilateral kidney agenesis. The initial clinical data was the presence of oligohydramnios detected by an ultrasound (US) at 19 gestational weeks. Another US at the term of the gestation showed anhydramnios, absence of renal silhouettes and bladder, which was corroborated when the girl was born. She died two days after she was born. Sufficient evidence exists that the methimazole administered during the early pregnancy can cause diverse congenital malformations including Potter's syndrome.

    Topics: Abnormalities, Multiple; Antithyroid Agents; Face; Female; Humans; Hyperthyroidism; Infant, Newborn; Kidney; Methimazole; Pregnancy; Pregnancy Complications; Pregnancy Trimester, First; Prenatal Exposure Delayed Effects; Syndrome

1999
Choanal atresia and hypothelia following methimazole exposure in utero: a second report.
    American journal of medical genetics, 1998, Jan-13, Volume: 75, Issue:2

    We report on a 3-year-old boy with bilateral choanal atresia, hypoplastic nipples, and developmental delay who had been exposed to carbimazole in utero because of maternal Graves disease. His combination of abnormalities and facial appearance strongly resembles that of a previously reported child exposed to methimazole (which is the active metabolite of carbimazole) in utero. We suggest that this represents a rare but distinct syndrome of methimazole teratogenicity, probably related to first-trimester exposure. Recognition of such teratogenic effects is clearly important for genetic counselling and for management of subsequent pregnancies.

    Topics: Abnormalities, Multiple; Antithyroid Agents; Child, Preschool; Choanal Atresia; Chromosomes, Human, Pair 22; Face; Female; Graves Disease; Hearing Loss; Humans; In Situ Hybridization, Fluorescence; Male; Methimazole; Muscle Hypotonia; Nipples; Pregnancy; Pregnancy Complications; Teratogens

1998
Elevated alpha-fetoprotein in pregnancy complicated by aplasia cutis after exposure to methimazole.
    Obstetrics and gynecology, 1988, Volume: 71, Issue:6 Pt 2

    A case of aplasia cutis after exposure to methimazole (Tapazole) in early pregnancy is described. Elevated maternal serum alpha-fetoprotein (MSAFP) and amniotic fluid alpha-fetoprotein (AFP) were found. Elevated MSAFP and amniotic fluid AFP in women exposed to methimazole may suggest this rare fetal condition.

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; alpha-Fetoproteins; Amniotic Fluid; Female; Humans; Methimazole; Pregnancy; Scalp; Skull

1988
The metabolism of iodine in 2 goitrous cretins compared with that in 2 patients receiving methimazole.
    The Journal of clinical endocrinology and metabolism, 1955, Volume: 15, Issue:1

    Topics: Abnormalities, Multiple; Antithyroid Agents; Congenital Hypothyroidism; Humans; Iodine; Iodine Radioisotopes; Methimazole; Radioisotopes; Syndrome; Thyroid Gland

1955
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