methenolone and Neoplasm-Metastasis

The effect of additive administration of methenolone oenanthate (Primobolan) on lipid metabolism was studied in 28 menopausal women with metastasizing carcinoma of the breast. In ten women hyperlipoproteinaemia type IIa was demonstrated in the course of treatment, while in two there was hyperlipoproteinaemia type IIb. One of the latter patients had a myocardial infarction in the course of treatment. There was no relationship between the level of hypercholesterolaemia and the methenolone dosage. Nor was it possible to classify the type of cholesterolaemia as a bile stasis syndrome. The hyperlipoproteinaemia regressed in every case once methenolone treatment was discontinued.

Topics: Bone Neoplasms; Breast Neoplasms; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Methenolone; Middle Aged; Neoplasm Metastasis; Skin Neoplasms

Forty-three patients with disseminated or inoperable carcinoma of the breast were treated with Metenolone Enanthate (Primobolan Depot) with doses of 400 to 1 200 mg/week for at least 3 months. Objective remissions lasting longer than 3 months occurred in 8 out of 41 evaluable patients. Soft tissue metastases responsed best. Liver and brain metastases were unaffected. The therapeutic efficiency of Primobolan Depot is comparable to that of testosterone propionate but the agent is less virilising.

Topics: Aged; Breast Neoplasms; Female; Hirsutism; Hoarseness; Humans; Libido; Lymphatic Metastasis; Methenolone; Middle Aged; Neoplasm Metastasis; Remission, Spontaneous

Topics: Adenocarcinoma, Scirrhous; Autopsy; Bone Neoplasms; Cyclophosphamide; Female; Humans; Long-Term Care; Methenolone; Middle Aged; Multiple Myeloma; Neoplasm Metastasis; Neoplasms, Multiple Primary; Remission, Spontaneous; Sacrum; Skull; Stomach Neoplasms

Topics: Breast Neoplasms; Castration; Climacteric; Cyclophosphamide; Cytoplasm; Electrophoresis; Estradiol; Estrogens; Ethinyl Estradiol; Female; Glucocorticoids; Humans; Hypophysectomy; Menopause; Methenolone; Neoplasm Metastasis; Protein Binding; Pyrrolidines; Receptors, Cell Surface; Tritium

Topics: Adrenal Cortex Hormones; Anabolic Agents; Androgens; Antineoplastic Agents; Breast Neoplasms; Castration; Estrogens; Geriatrics; Humans; Lactones; Methenolone; Neoplasm Metastasis; Neoplasms; Osteoporosis; Steroids