methenolone and Fanconi-Anemia

The preliminary results of a prospective study of androgen therapy in the treatment of bone marrow insufficiency in children are reported. This study includes 11 children with the Fanconi syndrome, 21 idiopathic and 3 with toxic aplastic anaemia. Nine patients died early in the course of treatment. Impaired liver function was observed in 28% of patients and virilization in 37% of patients.

Topics: Adolescent; Anemia, Aplastic; Child; Child, Preschool; Clinical Trials as Topic; Fanconi Anemia; Female; Follow-Up Studies; Humans; Liver; Male; Methenolone; Methyltestosterone; Oxymetholone; Testosterone Congeners; Virilism

Two types of chromosome abnormalitie are observed in the bone marrow and the blood of a patient with Fanconi's anemia. There abnormalities involved in two stages: firstly the presence of a clone with 47 chromosomes + 21, which was not found during later examinations. One and a half years later, following a decline in the hematological condition, there appeared duplication of certain chromosome segments of the long arm of the 3 chromosome and of the intermediate segment of the long arm of the 12 chromosome. This latter type of abnormality affected differently the bone marrow and the blood in the bone marrow, we found 2 clones, one bore 2 markers obtained from 3 and 12, the other and marker obtained from the 12 chromosome. In the blood, there was simply a minority clone with only the marker originating in the 3 chromosome. This observation should be compared with the descriptions made by other authors. In all cases abnormal clones present an apparently unbalanced karyotype, characterised by excess material.

Topics: ABO Blood-Group System; Anemia, Aplastic; Bone Marrow; Bone Marrow Cells; Child; Chromosome Aberrations; Chromosomes, Human, 1-3; Chromosomes, Human, 6-12 and X; Clone Cells; Diploidy; Fanconi Anemia; Glucocorticoids; Humans; Karyotyping; Male; Methenolone