methenamine has been researched along with Recrudescence in 46 studies
Methenamine: An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173)
hexamethylenetetramine : A polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomised, double blind, long term, crossover study 1 g twice daily of methenamine hippurate was compared with placebo for its preventive effect on recurrent attacks of acute cystitis." | 9.06 | Prevention of recurrent acute cystitis by methenamine hippurate: double blind controlled crossover long term study. ( Cronberg, S; Hellsten, S; Henriksson, L; Persson, KM; Stenberg, P; Welin, CO, 1987) |
| "Twenty girls, aged 5-12 years, with recurrent urinary tract infections, were treated with methenamine hippurate, Hiprex, for a period of 12 months." | 9.04 | Long-term prophylaxis with methenamine hippurate in girls with recurrent urinary tract infections. ( Petersen, S, 1978) |
| "To study the effects of continous low doses of antibacterial agents after eradication of bacteriuria in patients with recurrent urinary tract infection, 31 patients with documented recurrent urinary tract infection were allocated alternately to treatment with either co-trimoxazole (400 mg of suphamethoxazole and 80 mg of trimethoprim each night) or methenamine hippurate (1 g each night)." | 7.65 | Controlled trial comparing co-trimoxazole and methenamine hippurate in the prevention of recurrent urinary tract infections. ( Friedman, A; Kalowski, S; Kincaid-Smith, P; Nanra, RS; Radford, N; Standish, H, 1975) |
| "62." | 6.65 | Secondary prevention of recurrent urinary tract infections. Comparison of the effect of placebo, methenamine hippurate, nitrofurantoin and trimethoprim alone. ( Hajba, A; Junnila, SY; Kaarsalo, E; Kasanen, A; Sundquist, H, 1982) |
| "To test and compare the efficacy of methenamine hippurate for prevention of recurrent urinary tract infections with the current standard prophylaxis of daily low dose antibiotics." | 5.51 | Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial. ( Abouhajar, A; Ali, A; Carnell, S; Chadwick, T; Currer, S; Eardley, I; Forbes, R; Guerrero, K; Harding, C; Homer, T; Hussain, Z; King, W; Lazarowicz, H; Lecouturier, J; Mossop, H; Pearce, I; Pickard, R; Thiruchelvam, N; Vale, L; Walton, K; Watson, G, 2022) |
| " Methenamine had few adverse side effects for patients." | 5.51 | Safety and efficacy of methenamine hippurate for the prevention of recurrent urinary tract infections in adult renal transplant recipients: A single center, retrospective study. ( Ho, B; Hollyer, I; Ison, MG; Varias, F, 2019) |
| "In a randomised, double blind, long term, crossover study 1 g twice daily of methenamine hippurate was compared with placebo for its preventive effect on recurrent attacks of acute cystitis." | 5.06 | Prevention of recurrent acute cystitis by methenamine hippurate: double blind controlled crossover long term study. ( Cronberg, S; Hellsten, S; Henriksson, L; Persson, KM; Stenberg, P; Welin, CO, 1987) |
| "Twenty girls, aged 5-12 years, with recurrent urinary tract infections, were treated with methenamine hippurate, Hiprex, for a period of 12 months." | 5.04 | Long-term prophylaxis with methenamine hippurate in girls with recurrent urinary tract infections. ( Petersen, S, 1978) |
| " Because urinary tract infections (UTIs) are common, particularly in an increasing elderly population, the 'forgotten' drug, methenamine, may become important as a preventive therapy for recurrent UTIs." | 4.90 | Methenamine: a forgotten drug for preventing recurrent urinary tract infection in a multidrug resistance era. ( Cho, WC; Hammer, KD; Lo, TS; Zegarra, M, 2014) |
| "To study the effects of continous low doses of antibacterial agents after eradication of bacteriuria in patients with recurrent urinary tract infection, 31 patients with documented recurrent urinary tract infection were allocated alternately to treatment with either co-trimoxazole (400 mg of suphamethoxazole and 80 mg of trimethoprim each night) or methenamine hippurate (1 g each night)." | 3.65 | Controlled trial comparing co-trimoxazole and methenamine hippurate in the prevention of recurrent urinary tract infections. ( Friedman, A; Kalowski, S; Kincaid-Smith, P; Nanra, RS; Radford, N; Standish, H, 1975) |
| "62." | 2.65 | Secondary prevention of recurrent urinary tract infections. Comparison of the effect of placebo, methenamine hippurate, nitrofurantoin and trimethoprim alone. ( Hajba, A; Junnila, SY; Kaarsalo, E; Kasanen, A; Sundquist, H, 1982) |
| "New developments in treatment of urinary tract infections will be discussed." | 2.35 | New developments in the diagnosis and treatment of urinary tract infections. ( Kunn, CM, 1975) |
| " Methenamine had few adverse side effects for patients." | 1.51 | Safety and efficacy of methenamine hippurate for the prevention of recurrent urinary tract infections in adult renal transplant recipients: A single center, retrospective study. ( Ho, B; Hollyer, I; Ison, MG; Varias, F, 2019) |
| " No adverse reactions were recorded with the dosage used." | 1.28 | Long-term acidification of urine in patients treated for infected renal stones. ( Tiselius, HG; Wall, I, 1990) |
| "Recurrent urinary tract infections are known to occur among 5 per cent of all females." | 1.26 | The microbial flora of the urogenital tract in women with symptoms of recurrent urinary tract infection. The non-influence of methenaminehippurate treatment on the idigenous flora. ( Colleen, S; Luttropp, W; Mårdh, PA; Ripa, T, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (73.91) | 18.7374 |
| 1990's | 1 (2.17) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (17.39) | 24.3611 |
| 2020's | 3 (6.52) | 2.80 |
| Authors | Studies |
|---|---|
| Harding, C | 3 |
| Mossop, H | 2 |
| Homer, T | 1 |
| Chadwick, T | 2 |
| King, W | 1 |
| Carnell, S | 2 |
| Lecouturier, J | 2 |
| Abouhajar, A | 2 |
| Vale, L | 1 |
| Watson, G | 1 |
| Forbes, R | 2 |
| Currer, S | 1 |
| Pickard, R | 2 |
| Eardley, I | 2 |
| Pearce, I | 2 |
| Thiruchelvam, N | 2 |
| Guerrero, K | 1 |
| Walton, K | 2 |
| Hussain, Z | 1 |
| Lazarowicz, H | 1 |
| Ali, A | 2 |
| Stair, SL | 1 |
| Palmer, CJ | 1 |
| Lee, UJ | 1 |
| Gu, C | 1 |
| Ackerman, AL | 1 |
| Davis, C | 1 |
| Rantell, A | 1 |
| Barclay, J | 1 |
| Veeratterapillay, R | 1 |
| Sihra, N | 1 |
| Goodman, A | 1 |
| Zakri, R | 1 |
| Sahai, A | 1 |
| Malde, S | 1 |
| Brennand, C | 1 |
| Brown, H | 1 |
| Wilkinson, J | 1 |
| Hollyer, I | 1 |
| Varias, F | 1 |
| Ho, B | 1 |
| Ison, MG | 1 |
| Lo, TS | 1 |
| Hammer, KD | 1 |
| Zegarra, M | 1 |
| Cho, WC | 1 |
| Jahromi, MS | 1 |
| Mure, A | 1 |
| Gomez, CS | 1 |
| Haugen, W | 1 |
| Spigset, O | 1 |
| Smellie, JM | 1 |
| Høivik, HO | 1 |
| Gundersen, R | 1 |
| Osmundsen, K | 1 |
| Halvorsen, P | 1 |
| Hjortdahl, P | 1 |
| Stokke, JG | 1 |
| Kasanen, A | 3 |
| Sundquist, H | 2 |
| Elo, J | 2 |
| Anttila, M | 1 |
| Kangas, L | 1 |
| Seppänen, J | 1 |
| Sulkava, T | 1 |
| Vaalasti, T | 1 |
| Korhonen, H | 1 |
| Räisänen, S | 1 |
| Ylitalo, P | 1 |
| Junnila, SY | 1 |
| Kaarsalo, E | 2 |
| Hajba, A | 1 |
| Petersen, S | 1 |
| O'Dea, MJ | 1 |
| Malek, RS | 1 |
| Farrow, GM | 1 |
| Krechnáková, A | 1 |
| Dzúrik, R | 1 |
| Kass, EH | 1 |
| Colleen, S | 1 |
| Luttropp, W | 1 |
| Mårdh, PA | 1 |
| Ripa, T | 1 |
| Sarna, S | 1 |
| Ahava, K | 1 |
| Lepo, A | 1 |
| Keswani, RK | 1 |
| Chugh, TD | 1 |
| Hooda, RS | 1 |
| Beniwal, JS | 1 |
| Parvio, S | 1 |
| Kunn, CM | 1 |
| Sher, N | 1 |
| Freeman, RB | 1 |
| Smith, WM | 1 |
| Richardson, JA | 1 |
| Hennelly, PJ | 1 |
| Thurm, RH | 1 |
| Urner, C | 1 |
| Vaillancourt, JA | 1 |
| Griep, RJ | 1 |
| Bromer, L | 1 |
| Stamey, TA | 1 |
| Resnick, B | 1 |
| Rubinoff, H | 1 |
| Kalowski, S | 2 |
| Nanra, RS | 2 |
| Friedman, A | 1 |
| Radford, N | 1 |
| Standish, H | 1 |
| Kincaid-Smith, P | 2 |
| Wall, I | 1 |
| Tiselius, HG | 1 |
| Cronberg, S | 2 |
| Welin, CO | 2 |
| Henriksson, L | 2 |
| Hellsten, S | 2 |
| Persson, KM | 1 |
| Stenberg, P | 2 |
| Brumfitt, W | 1 |
| Hamilton-Miller, JM | 1 |
| Persson, K | 1 |
| Horcicková, M | 1 |
| Prát, V | 1 |
| Hatala, M | 1 |
| Nezádalová, E | 1 |
| Milotová, Z | 1 |
| Gow, JG | 1 |
| Harris, RE | 1 |
| Gilstrap, LC | 1 |
| Korneĭchuk, AG | 1 |
| Starinets, GA | 1 |
| Hiltunen, R | 1 |
| Soini, V | 1 |
| Sonnenschein, H | 1 |
| Gillenwater, JY | 1 |
| Harding, GK | 1 |
| Ronald, AR | 1 |
| Budhraja, SN | 1 |
| Rangiah, T | 1 |
| Smile, SR | 1 |
| Chidambaram, M | 1 |
| Sharma, KB | 1 |
| Wallerström, BG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Methenamine Hippurate to Reduce Antibiotic Prescribing Due to New Episodes of Urinary Tract Infections (UTI) in Elderly Women With Recurrent UTI - a Triple- Blinded, Randomized Placebo-controlled Phase IV Study[NCT04077580] | Phase 4 | 400 participants (Anticipated) | Interventional | 2019-11-01 | Enrolling by invitation | ||
| Probiotic and Effects on Multi-Drug Resistant Urinary Tract Infection[NCT03644966] | 25 participants (Actual) | Interventional | 2018-07-05 | Completed | |||
| Clinical Trial of Nettle and Cranberry Capsules for Prevention of Urinary Tract Infection[NCT05880602] | 60 participants (Anticipated) | Interventional | 2023-07-05 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for methenamine and Recrudescence
| Article | Year |
|---|---|
Evidence-based review of nonantibiotic urinary tract infection prevention strategies for women: a patient-centered approach.
Topics: Complementary Therapies; Estrogens; Female; Humans; Methenamine; Patient-Centered Care; Recurrence; | 2023 |
Nonantibiotic prevention and management of recurrent urinary tract infection.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Estrogens; Female; Hippurates; Humans; Male; Mannose; Methe | 2018 |
Methenamine: a forgotten drug for preventing recurrent urinary tract infection in a multidrug resistance era.
Topics: Anti-Infective Agents, Urinary; Drug Administration Schedule; Drug Dosage Calculations; Drug Resista | 2014 |
UTIs in patients with neurogenic bladder.
Topics: Administration, Intravesical; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antibiotic Prop | 2014 |
New developments in the diagnosis and treatment of urinary tract infections.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Carbenicillin; Female; Humans; Hydroxamic | 1975 |
13 trials available for methenamine and Recrudescence
| Article | Year |
|---|---|
Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Female; Hippurates; Humans; Methen | 2022 |
ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial.
Topics: Adult; Aged; Antibiotic Prophylaxis; Bias; Computer Security; Female; Hippurates; Humans; Methenamin | 2018 |
[Prevention of recurrent cystitis in fertile women. A double-blind comparison of Hiprex and placebo in general practice].
Topics: Adolescent; Adult; Clinical Trials as Topic; Cystitis; Double-Blind Method; Female; Hippurates; Huma | 1984 |
Secondary prevention of urinary tract infections. The role of trimethoprim alone.
Topics: Adult; Anti-Infective Agents; Child; Drug Combinations; Female; Follow-Up Studies; Humans; Male; Met | 1983 |
Combination of trimethoprim and methenamine hippurate in the treatment of acute urinary tract infections.
Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Infective Agents, Urinary; Double-Blind Method; Drug Co | 1983 |
Secondary prevention of recurrent urinary tract infections. Comparison of the effect of placebo, methenamine hippurate, nitrofurantoin and trimethoprim alone.
Topics: Clinical Trials as Topic; Hippurates; Humans; Methenamine; Nitrofurantoin; Placebos; Recurrence; Tri | 1982 |
Long-term prophylaxis with methenamine hippurate in girls with recurrent urinary tract infections.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Female; Hippurates; Humans; Meth | 1978 |
Long-term therapy for chronic bacteriuria in men. U.S. Public Health Service cooperative study.
Topics: Adult; Aged; Anti-Infective Agents, Urinary; Bacteriuria; Chronic Disease; Clinical Trials as Topic; | 1975 |
Prevention of recurrent acute cystitis by methenamine hippurate: double blind controlled crossover long term study.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Clinical Trials as To | 1987 |
A comparative trial of hexamine hippurate and hexamine mandelate in prevention of recurrent infection of the urinary tract.
Topics: Albuminuria; Back Pain; Clinical Trials as Topic; Depression; Diarrhea; Digestion; Drug Hypersensiti | 1974 |
Comparison of long-term, low-dosage nitrofurantoin, methenamine hippurate, trimethoprim and trimethoprim-sulphamethoxazole on the control of recurrent urinary tract infection.
Topics: Aged; Drug Tolerance; Female; Hippurates; Humans; In Vitro Techniques; Male; Methenamine; Middle Age | 1974 |
Co-trimoxazole in urinary tract infection.
Topics: Acute Kidney Injury; Adult; Anti-Infective Agents; Bacteriuria; Clinical Trials as Topic; Drug Combi | 1973 |
A controlled study of antimicrobial prophylaxis of recurrent urinary infection in women.
Topics: Adolescent; Adult; Aged; Ascorbic Acid; Bacteria; Bacteriological Techniques; Child; Child, Preschoo | 1974 |
28 other studies available for methenamine and Recrudescence
| Article | Year |
|---|---|
An oldie but a goodie: Methenamine as a nonantibiotic solution to the prevention of recurrent urinary tract infections.
Topics: Humans; Methenamine; Recurrence; Urinary Tract Infections | 2023 |
Lower urinary tract infections in women.
Topics: Age Factors; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Asymptomatic Infections; Atrophi | 2017 |
Non-antibiotic options for recurrent urinary tract infections in women.
Topics: Antibiotic Prophylaxis; Drugs, Chinese Herbal; Evidence-Based Medicine; Female; Hippurates; Humans; | 2017 |
Non-antibiotic options for recurrent urinary tract infections in women.
Topics: Antibiotic Prophylaxis; Drugs, Chinese Herbal; Evidence-Based Medicine; Female; Hippurates; Humans; | 2017 |
Non-antibiotic options for recurrent urinary tract infections in women.
Topics: Antibiotic Prophylaxis; Drugs, Chinese Herbal; Evidence-Based Medicine; Female; Hippurates; Humans; | 2017 |
Non-antibiotic options for recurrent urinary tract infections in women.
Topics: Antibiotic Prophylaxis; Drugs, Chinese Herbal; Evidence-Based Medicine; Female; Hippurates; Humans; | 2017 |
Safety and efficacy of methenamine hippurate for the prevention of recurrent urinary tract infections in adult renal transplant recipients: A single center, retrospective study.
Topics: Adult; Anti-Infective Agents, Urinary; Bacteria; Escherichia coli; Female; Hippurates; Humans; Kidne | 2019 |
[How to prevent recurrent urinary tract infections after menopause?].
Topics: Aged; Anti-Infective Agents, Urinary; Antibiotic Prophylaxis; Drug Resistance, Bacterial; Estrogens; | 2015 |
[Preventive antibiotic therapy of recurring urinary tract infections in children].
Topics: Child; Child, Preschool; Female; Humans; Infant; Male; Methenamine; Nalidixic Acid; Nitrofurantoin; | 1981 |
Malacoplakia of the urinary tract: challenges and frustations with 10 cases.
Topics: Adult; Aged; Ammonium Chloride; Anti-Bacterial Agents; Electrocoagulation; Female; Humans; Liver Dis | 1977 |
[Prevention of chronic pyelonephritis relapses using metenamine hipuran (author's transl)].
Topics: Adult; Aged; Chronic Disease; Female; Hippurates; Humans; Methenamine; Middle Aged; Pyelonephritis; | 1979 |
An approach to the management of resistant urinary infections.
Topics: Adult; Anti-Infective Agents, Urinary; Bacterial Infections; Drug Resistance, Microbial; Female; Hip | 1979 |
The microbial flora of the urogenital tract in women with symptoms of recurrent urinary tract infection. The non-influence of methenaminehippurate treatment on the idigenous flora.
Topics: Adult; Bacteroides; Enterobacteriaceae; Female; Humans; Methenamine; Pyuria; Recurrence; Urinary Tra | 1978 |
Methenamine hippurate in urinary tract infections in children: prophylaxis, treatment and side effects.
Topics: Age Factors; Child; Humans; Methenamine; Nitrofurantoin; Recurrence; Sulfisoxazole; Urinary Tract In | 1978 |
Prevention of recurrent urinary tract infection with methenamine mandelate.
Topics: Humans; Methenamine; Recurrence; Urinary Tract Infections | 1976 |
Methenamine hippurate ('Hiprex') in the treatment of chronic urinary tract infections: a trial in a geriatric hospital.
Topics: Aged; Chronic Disease; Drug Evaluation; Female; Humans; Methenamine; Recurrence; Urinary Tract Infec | 1976 |
Prophylactic chemotherapy with low-dosage trimethoprim-sulfamethoxazole following acute urinary tract infections in children.
Topics: Ampicillin; Bacterial Infections; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Esche | 1975 |
Editorial: A clinical classification of urinary tract infections based upon origin.
Topics: Bacteriuria; Chronic Disease; Escherichia coli Infections; Female; Humans; Male; Methenamine; Nitrof | 1975 |
Letter: Long-term effects of treatment for recurrent bacteriuria.
Topics: Bacteriuria; Drug Therapy, Combination; Female; Humans; Methenamine; Nitrofurantoin; Recurrence; Sul | 1975 |
Controlled trial comparing co-trimoxazole and methenamine hippurate in the prevention of recurrent urinary tract infections.
Topics: Adult; Aged; Bacteriuria; Drug Combinations; Female; Follow-Up Studies; Hemagglutinins; Hippurates; | 1975 |
Long-term acidification of urine in patients treated for infected renal stones.
Topics: Adult; Ammonium Chloride; Anti-Infective Agents, Urinary; Ascorbic Acid; Female; Hippurates; Humans; | 1990 |
Recurrent bacteriuria: 1. Prior therapy.
Topics: Aged; Anti-Infective Agents, Urinary; Bacteriuria; Drug Resistance, Microbial; Female; Humans; Hydro | 1989 |
Prevention of recurrent acute cystitis by methenamine hippurate.
Topics: Adult; Anti-Infective Agents, Urinary; Cystitis; Female; Hippurates; Humans; Methenamine; Nitrofuran | 1987 |
[Renaissance for the use of methenamine in the prevention of recurrent cystitis].
Topics: Cystitis; Female; Humans; Methenamine; Recurrence | 1988 |
[Methenamine hippurate VUFB and mandelamine VUFB in the prevention of recurrent dysuria in women].
Topics: Adult; Aged; Anti-Infective Agents, Urinary; Bacteria; Bacteriuria; Female; Hippurates; Humans; Mand | 1986 |
Prevention of recurrent pyelonephritis during pregnancy.
Topics: Adult; Ampicillin; Anti-Infective Agents, Urinary; Bacteriuria; Cephalothin; Female; Humans; Methena | 1974 |
[Treatment and prevention of recurrent neuritis of the facial nerve].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Child; Facial Nerve; Female; Glucose; Humans; Male; Methen | 1974 |
Recurring urinary tract infection. An overview.
Topics: Anti-Bacterial Agents; Child; Child, Preschool; Female; Humans; Infant; Male; Methenamine; Recurrenc | 1973 |
Recurrent urinary infection.
Topics: Anti-Bacterial Agents; Bacteriological Techniques; Bacteriuria; Child; Cystitis; Female; Humans; Kid | 1973 |
An assessment of the value of prolonged use of methanamine mandelate in the treatment of chronic urinary tract infections.
Topics: Chronic Disease; Female; Humans; Male; Methenamine; Recurrence; Time Factors; Urinary Tract Infectio | 1972 |
[Methamine hippurate--an old antiseptic in a new formula].
Topics: Acute Disease; Administration, Oral; Adult; Chronic Disease; Cystitis; Drug Combinations; Female; Hi | 1972 |