methenamine has been researched along with Female Genital Diseases in 2 studies
Methenamine: An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173)
hexamethylenetetramine : A polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knoff, T | 1 |
| Thomlinson, J | 1 |
| Williams, JD | 1 |
| Cope, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy and Cost-effectiveness of a 24-hour Course of metheNamine Hippurate for Preventing Post-Operative Urinary Tract Infection[NCT02358993] | 201 participants (Actual) | Interventional | 2014-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
All patients who submit urine cultures that are positive will have sensitivities performed as per standard care. The prevalence of bacterial species and sensitivities will be collected (NCT02358993)
Timeframe: 3 weeks post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Methenamine | 0 |
| Ciprofloxacin | 0 |
All patients will be encouraged to submit urine cultures prior to treatment, but this is not always possible. Amongst patients who undergo urine culture as part of standard of care for UTI, the rate of positive cultures will be identified. (NCT02358993)
Timeframe: 3 weeks post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Methenamine | 5 |
| Ciprofloxacin | 4 |
We plan to analyze the prevalence of UTI in this population that meet the definitions of symptomatic UTI and catheter-associated UTI according to the National Healthcare Safety Network criteria. (NCT02358993)
Timeframe: 3 weeks post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Methenamine | 10 |
| Ciprofloxacin | 6 |
This is defined as any symptomatic UTI requiring treatment with antibiotics as determined by the development of 2 or more of the following symptoms, in the absence of vaginal symptoms: urinary frequency; urinary urgency; dysuria; fever over 38oC/100.4oF; suprapubic, flank, or back pain; and/or chills. (NCT02358993)
Timeframe: 3 weeks post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Methenamine | 12 |
| Ciprofloxacin | 12 |
This is defined as any symptomatic UTI requiring treatment with antibiotics as determined by the development of 2 or more of the following symptoms, in the absence of vaginal symptoms: urinary frequency; urinary urgency; dysuria; fever over 38oC/100.4oF; suprapubic, flank, or back pain; and/or chills. (NCT02358993)
Timeframe: 3 weeks post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Methenamine | 13 |
| Ciprofloxacin | 12 |
2 trials available for methenamine and Female Genital Diseases
| Article | Year |
|---|---|
[Methenamine hippurate. Short-term catheterization in gynecologic surgery. A double-blind comparison of Hiprex and placebo].
Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Urinary; Bacteriuria; Clinical Trials as Topic; Doub | 1985 |
Persistence of bacteriuria following gynaecological surgery: a trial of methenamine hippurate.
Topics: Bacteriuria; Clinical Trials as Topic; Female; Genital Diseases, Female; Humans; Hysterectomy; Methe | 1968 |