methenamine has been researched along with Cystitis in 14 studies
Methenamine: An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173)
hexamethylenetetramine : A polycyclic cage that is adamantane in which the carbon atoms at positions 1, 3, 5 and 7 are replaced by nitrogen atoms.
Cystitis: Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomised, double blind, long term, crossover study 1 g twice daily of methenamine hippurate was compared with placebo for its preventive effect on recurrent attacks of acute cystitis." | 9.06 | Prevention of recurrent acute cystitis by methenamine hippurate: double blind controlled crossover long term study. ( Cronberg, S; Hellsten, S; Henriksson, L; Persson, KM; Stenberg, P; Welin, CO, 1987) |
| "Methenamine hippurate seems to enhance barrier function as evidenced by decreased urothelial permeability and increased urinary IgA levels, without worsening inflammation." | 5.72 | The Impact of Methenamine Hippurate Treatment on Urothelial Integrity and Bladder Inflammation in Aged Female Mice and Women With Urinary Tract Infections. ( Chu, CM; Ligon, MM; Lowder, JL; McDaniel, K; Mora, A; Mysorekar, IU; Sawhill, JL, 2022) |
| "In a randomised, double blind, long term, crossover study 1 g twice daily of methenamine hippurate was compared with placebo for its preventive effect on recurrent attacks of acute cystitis." | 5.06 | Prevention of recurrent acute cystitis by methenamine hippurate: double blind controlled crossover long term study. ( Cronberg, S; Hellsten, S; Henriksson, L; Persson, KM; Stenberg, P; Welin, CO, 1987) |
| "Methenamine hippurate seems to enhance barrier function as evidenced by decreased urothelial permeability and increased urinary IgA levels, without worsening inflammation." | 1.72 | The Impact of Methenamine Hippurate Treatment on Urothelial Integrity and Bladder Inflammation in Aged Female Mice and Women With Urinary Tract Infections. ( Chu, CM; Ligon, MM; Lowder, JL; McDaniel, K; Mora, A; Mysorekar, IU; Sawhill, JL, 2022) |
| "Acute cystitis is one of the most common health-related problems in the female population." | 1.38 | Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence? ( Arnos, P; Athanasiou, S; Falagas, ME; Mavros, MN; Pergialiotis, V; Pitsouni, E, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Sawhill, JL | 1 |
| Mora, A | 1 |
| McDaniel, K | 1 |
| Ligon, MM | 1 |
| Lowder, JL | 1 |
| Mysorekar, IU | 1 |
| Chu, CM | 1 |
| Pergialiotis, V | 1 |
| Arnos, P | 1 |
| Mavros, MN | 1 |
| Pitsouni, E | 1 |
| Athanasiou, S | 1 |
| Falagas, ME | 1 |
| WENZL, JE | 1 |
| GREENE, LF | 1 |
| HARRIS, LE | 1 |
| BLOEMERTZ, CB | 1 |
| Høivik, HO | 2 |
| Gundersen, R | 2 |
| Osmundsen, K | 2 |
| Halvorsen, P | 1 |
| Hjortdahl, P | 1 |
| Stokke, JG | 1 |
| Cronberg, S | 2 |
| Welin, CO | 2 |
| Henriksson, L | 2 |
| Hellsten, S | 2 |
| Persson, KM | 1 |
| Stenberg, P | 2 |
| Brumfitt, W | 1 |
| Hamilton-Miller, JM | 1 |
| Persson, K | 1 |
| Lang, GR | 1 |
| Levin, S | 1 |
| Gillenwater, JY | 1 |
| Wallerström, BG | 1 |
| Ross, RR | 1 |
| Conway, GF | 1 |
| Gibson, GR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Methenamine Hippurate to Reduce Antibiotic Prescribing Due to New Episodes of Urinary Tract Infections (UTI) in Elderly Women With Recurrent UTI - a Triple- Blinded, Randomized Placebo-controlled Phase IV Study[NCT04077580] | Phase 4 | 400 participants (Anticipated) | Interventional | 2019-11-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for methenamine and Cystitis
| Article | Year |
|---|---|
Diagnosis and treatment of urinary tract infections.
Topics: Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Bacteriuria; Cephalosporins; Chloramphenicol; | 1971 |
3 trials available for methenamine and Cystitis
| Article | Year |
|---|---|
[Prevention of recurrent cystitis in fertile women. A double-blind comparison of Hiprex and placebo in general practice].
Topics: Adolescent; Adult; Clinical Trials as Topic; Cystitis; Double-Blind Method; Female; Hippurates; Huma | 1984 |
Prevention of recurrent acute cystitis by methenamine hippurate: double blind controlled crossover long term study.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Clinical Trials as To | 1987 |
[Frequent cystitis in elderly women. A double-blind comparison of Hiprex and placebo in general practice].
Topics: Aged; Anti-Infective Agents, Urinary; Clinical Trials as Topic; Cystitis; Double-Blind Method; Hippu | 1986 |
10 other studies available for methenamine and Cystitis
| Article | Year |
|---|---|
The Impact of Methenamine Hippurate Treatment on Urothelial Integrity and Bladder Inflammation in Aged Female Mice and Women With Urinary Tract Infections.
Topics: Animals; Cystitis; Dextrans; Estrogens; Female; Fluoresceins; Hippurates; Humans; Immunoglobulin A; | 2022 |
Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence?
Topics: Acute Disease; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Clinical | 2012 |
EOSINOPHILIC CYSTITIS.
Topics: Biopsy; Child; Congenital Abnormalities; Cystitis; Eosinophilia; Escherichia coli Infections; Humans | 1964 |
[Critical comments on cystitis treatment].
Topics: Cystitis; Humans; Methenamine; Plants; Salicylates | 1955 |
Prevention of recurrent acute cystitis by methenamine hippurate.
Topics: Adult; Anti-Infective Agents, Urinary; Cystitis; Female; Hippurates; Humans; Methenamine; Nitrofuran | 1987 |
[Renaissance for the use of methenamine in the prevention of recurrent cystitis].
Topics: Cystitis; Female; Humans; Methenamine; Recurrence | 1988 |
Recurrent urinary infection.
Topics: Anti-Bacterial Agents; Bacteriological Techniques; Bacteriuria; Child; Cystitis; Female; Humans; Kid | 1973 |
[Methamine hippurate--an old antiseptic in a new formula].
Topics: Acute Disease; Administration, Oral; Adult; Chronic Disease; Cystitis; Drug Combinations; Female; Hi | 1972 |
Hemorrhagic cystitis following accidental overdose of methenamine mandelate.
Topics: Child, Preschool; Cystitis; Hemorrhage; Humans; Male; Methenamine; Radiography | 1970 |
A clinical appraisal of methenamine hippurate in urinary tract infections.
Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Cystitis; Female; Hippurates; Humans; Male; | 1970 |