Methazolamide: A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
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Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.Bioorganic & medicinal chemistry letters, 2003, Mar-24, Volume: 13, Issue:6
Topics: Animals; Antigens, Neoplasm; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Carbonic Anhydras | 2003 |
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.Journal of medicinal chemistry, 2003, Dec-04, Volume: 46, Issue:25
Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anh | 2003 |
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.Bioorganic & medicinal chemistry letters, 2004, Jul-16, Volume: 14, Issue:14
Topics: Amino Acid Sequence; Animals; Carbonic Anhydrase Inhibitors; Cytosol; Drug Design; Humans; Hydrogen- | 2004 |
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.Bioorganic & medicinal chemistry letters, 2004, Dec-06, Volume: 14, Issue:23
Topics: Benzolamide; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic An | 2004 |
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.Bioorganic & medicinal chemistry letters, 2005, May-02, Volume: 15, Issue:9
Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carb | 2005 |
Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.Bioorganic & medicinal chemistry letters, 2006, Sep-15, Volume: 16, Issue:18
Topics: Carbonic Anhydrase Inhibitors; Cell Hypoxia; Cell Membrane; Cytosol; Humans; Isoenzymes; Molecular S | 2006 |
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.Journal of medicinal chemistry, 2006, Sep-07, Volume: 49, Issue:18
Topics: Antigens, Neoplasm; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carbonic Anhydrase IX; Car | 2006 |
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties.Bioorganic & medicinal chemistry letters, 2007, Mar-15, Volume: 17, Issue:6
Topics: Carbonic Anhydrase Inhibitors; Cell Membrane; Cytosol; Humans; Hydroxamic Acids; Indicators and Reag | 2007 |
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.Bioorganic & medicinal chemistry letters, 2008, Jan-15, Volume: 18, Issue:2
Topics: Amines; Carbonic Anhydrase Inhibitors; Copper; Heterocyclic Compounds; Isoenzymes; Neoplasms; Sulfon | 2008 |
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides.Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7
Topics: Benzenesulfonamides; Binding Sites; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cytosol; Hum | 2008 |
Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11
Topics: Amino Acid Sequence; Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhyd | 2008 |
Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.European journal of medicinal chemistry, 2010, Volume: 45, Issue:9
Topics: Antigens, Neoplasm; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Carb | 2010 |
Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associatEuropean journal of medicinal chemistry, 2014, Volume: 71Topics: Antigens, Neoplasm; Antineoplastic Agents; Carbonic Anhydrase I; Carbonic Anhydrase II; Carbonic Anh | 2014 |
Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.European journal of medicinal chemistry, 2014, Jul-23, Volume: 82Topics: Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Membrane; Dose-Response Relationship, Drug; | 2014 |